Fixes #2929 - Intestinal tuft cell textual definition

[Caroline-99]

Fixes #2929

• Improved Intestinal tuft cell textual definition
• Added references

The term 'cytospinule' has been added to GO and will be linked to this term once available.

[Caroline-99]

#gogoeditdiff

[github-actions]

Here's a diff of how these changes impact the classified ontology (on -base file):

Ontology comparison

Left

• Ontology IRI: http://purl.obolibrary.org/obo/cl/cl-base.owl
• Version IRI: http://purl.obolibrary.org/obo/cl/releases/2025-02-06/cl-base.owl
• Loaded from: file:/__w/cell-ontology/cell-ontology/src/ontology/cl-base-master.owl/cl-base.owl

Right

• Ontology IRI: http://purl.obolibrary.org/obo/cl/cl-base.owl
• Version IRI: http://purl.obolibrary.org/obo/cl/releases/2025-02-06/cl-base.owl
• Loaded from: file:/__w/cell-ontology/cell-ontology/src/ontology/cl-base-pr.owl/cl-base.owl

Ontology imports

Ontology annotations

intestinal tuft cell http://purl.obolibrary.org/obo/CL_0019032

Removed

• intestinal tuft cell IAO_0000115 "Any brush cell that is part of the intestinal epithelium."

  • hasDbXref "PMID:39358509"

  • hasDbXref "PMID:22527717"

Added

• intestinal tuft cell IAO_0000115 "A tuft cell that is part of the intestinal epithelium, characterized by a distinctive apical tuft and lateral cytospinules connecting to neighbouring cells. This cell senses luminal stimuli via taste receptors and succinate signalling, initiating type 2 immune responses through the secretion of interleukin-25 while modulating epithelial regeneration through prostaglandin synthesis. It expresses key molecular markers such as doublecortin-like kinase 1 (DCLK1) in mice (Hendel et al., 2022), and KIT proto-oncogene in humans (Huang et al., 2024). Developed from intestinal crypt stem cells, this cell requires transcription factor POU2F3 for its development."

  • hasDbXref "PMID:35237268"

  • hasDbXref "PMID:39358509"

  • hasDbXref "PMID:29714721"

  • hasDbXref "PMID:22527717"

[github-actions]

Here's a diff of your edit file (unreasoned)

Ontology comparison

Left

• Ontology IRI: http://purl.obolibrary.org/obo/cl.owl
• Version IRI: None
• Loaded from: file:/__w/cell-ontology/cell-ontology/master/src/ontology/cl-edit.owl

Right

• Ontology IRI: http://purl.obolibrary.org/obo/cl.owl
• Version IRI: None
• Loaded from: file:/__w/cell-ontology/cell-ontology/branch/src/ontology/cl-edit.owl

Ontology imports

Ontology annotations

intestinal tuft cell http://purl.obolibrary.org/obo/CL_0019032

Removed

• intestinal tuft cell definition "Any brush cell that is part of the intestinal epithelium."

  • database_cross_reference "PMID:39358509"

  • database_cross_reference "PMID:22527717"

Added

• intestinal tuft cell definition "A tuft cell that is part of the intestinal epithelium, characterized by a distinctive apical tuft and lateral cytospinules connecting to neighbouring cells. This cell senses luminal stimuli via taste receptors and succinate signalling, initiating type 2 immune responses through the secretion of interleukin-25 while modulating epithelial regeneration through prostaglandin synthesis. It expresses key molecular markers such as doublecortin-like kinase 1 (DCLK1) in mice (Hendel et al., 2022), and KIT proto-oncogene in humans (Huang et al., 2024). Developed from intestinal crypt stem cells, this cell requires transcription factor POU2F3 for its development."

  • database_cross_reference "PMID:39358509"

  • database_cross_reference "PMID:29714721"

  • database_cross_reference "PMID:35237268"

  • database_cross_reference "PMID:22527717"