v0.10.0

sceptre 0.10.0 (2024-04-02)

Version 0.10.0 is a major update to the sceptre package. This version provides support for the analysis of large-scale single-cell CRISPR screen data. It also includes several other, minor updates.

• We have introduced the ondisc-backed sceptre_object, which is a special kind of sceptre_object in which the data are stored on-disk as opposed to in-memory.

• We have made the sceptre R package compatible with the sceptre Nextflow pipeline.

• We have added the function plot_response_grna_target_pair(), which creates a violin plot of the expression level of a specified gene across treatment and control groups of a specified target.

• We have added the function get_grna_assignments(), which facilitates obtaining the gRNA-to-cell assignments.

• We have updated the sceptre e-book, adding two new parts: a part on at-scale sceptre and a part on the methodology underlying sceptre.

• We have made the discovery pairs data frame and the positive control pairs data frame optional arguments to the set_analysis_parameters() function.

• We have added a comprehensive suite of unit tests to help verify correctness of the code.

• We have fleshed out the man pages, for example by adding a runable example to each.

• We have moved the example data within the sceptre package into the companion sceptredata package.

• We have issued minor bug fixes.

Please note that v0.10.0 is a higher version number than v0.9.2.