Initial version, v0.0.1

Default (Linux).sublime-keymap

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+[
+    {
+        "keys": ["ctrl+shift+r"],
+        "command": "reverse_complement"
+    }
+]

Default (OSX).sublime-keymap

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+[
+    {
+        "keys": ["super+shift+r"],
+        "command": "reverse_complement"
+    }
+]

Default (Windows).sublime-keymap

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+[
+    {
+        "keys": ["ctrl+shift+r"],
+        "command": "reverse_complement"
+    }
+]

Main.sublime-menu

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+[
+    {
+        "id": "edit",
+        "children": [
+            {
+                "caption": "Nucleotides",
+                "id": "nucleotides",
+                "children": [
+                    {
+                        "command": "reverse_complement"
+          }
+        ]
+      }
+    ]
+  }
+]

README.md

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+ACTG for SublimeText
+====================
+
+Nucleotide syntax highlighting and reverse complement support. This is handy for "stare at the screen and squint" DNA analysis.
+
+Features
+--------
+
+* Choose 'Nucleotides' syntax highlighting to colorize ACTG and N.
+* Automatically associates .fa, .fasta, .fq, .fastq, .sam, and .vcf files.
+* Make a selection and hit Control-Shift-R (or Command-Shift-R on Mac) to replace it with the reverse complement.
+
+Bugs
+----
+
+* ACTG and N are simply highlighted in place, which can make for some interestingly colored VCF comments and quality strings. A more clever regex would help, if only I could fathom the tmLanguage backreference match syntax.
+
+Patches welcome.
+
+Releases
+--------
+
+* 0.0.1: Initial release, 2014-09-29

actg.JSON-tmLanguage

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+{
+    "name": "Nucleotides",
+    "scopeName": "source.nucleotides",
+    "fileTypes": [
+    "fq",
+    "fastq",
+    "fa",
+    "fasta",
+    "sam",
+    "vcf"
+  ],
+    "patterns": [
+        {
+            "match": "A",
+            "name": "keyword.control.nucleotides",
+            "comment": "adenine"
+    },
+        {
+            "match": "C",
+            "name": "entity.name.function.nucleotides",
+            "comment": "cytosine"
+    },
+        {
+            "match": "T",
+            "name": "constant.numeric.source.nucleotides",
+            "comment": "thymine"
+    },
+        {
+            "match": "G",
+            "name": "string.quoted.source.nucleotides",
+            "comment": "guanine"
+    },
+        {
+            "match": "N",
+            "name": "comment.block.source.nucleotides",
+            "comment": "unknown"
+    }
+  ],
+    "uuid": "34f308ec-03a9-428e-93dd-d8eae6648d7f"
+}

actg.py

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+'''
+	actg.py
+
+	Reverse complement plugin for Sublime Text 2
+'''
+import sublime, sublime_plugin
+
+class ReverseComplementCommand(sublime_plugin.TextCommand):
+	def complement(self, sequence, reverse=False):
+		"""
+			Compute the complement of a DNA sequence.
+
+			If reverse is True, reverse it too.
+		"""
+		flip = {
+			'A': 'T',
+			'C': 'G',
+			'G': 'C',
+			'T': 'A',
+			'N': 'N',
+			'a': 't',
+			'c': 'g',
+			'g': 'c',
+			't': 'a',
+			'n': 'n'
+		}
+
+		complines = []
+
+		# Gracefully handle line endings
+		if '\n' in sequence:
+			postfix = '\n'
+		else:
+			postfix = ''
+
+		for line in sequence.split('\n'):
+			line_complement = []
+			for i in list(line):
+				if not i in flip:
+					sublime.error_message('Selection contains non-nucleotides.')
+					return False
+				line_complement.append(flip[i])
+
+			if reverse:
+				complines.append(''.join(line_complement[::-1]))
+			else:
+				complines.append(''.join(line_complement))
+
+		return postfix.join(complines)
+
+	def run(self, edit):
+		sels = self.view.sel()
+		for sel in sels:
+			if not sel.empty():
+				ret = self.complement(self.view.substr(sel), reverse=True)
+				if(ret):
+					self.view.replace(edit, sel, ret)

actg.tmLanguage

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+<?xml version="1.0" encoding="UTF-8"?>
+<!DOCTYPE plist PUBLIC "-//Apple Computer//DTD PLIST 1.0//EN" "http://www.apple.com/DTDs/PropertyList-1.0.dtd">
+<plist version="1.0">
+<dict>
+	<key>fileTypes</key>
+	<array>
+		<string>fq</string>
+		<string>fastq</string>
+		<string>fa</string>
+		<string>fasta</string>
+		<string>sam</string>
+		<string>vcf</string>
+	</array>
+	<key>name</key>
+	<string>Nucleotides</string>
+	<key>patterns</key>
+	<array>
+		<dict>
+			<key>comment</key>
+			<string>adenine</string>
+			<key>match</key>
+			<string>A</string>
+			<key>name</key>
+			<string>keyword.control.nucleotides</string>
+		</dict>
+		<dict>
+			<key>comment</key>
+			<string>cytosine</string>
+			<key>match</key>
+			<string>C</string>
+			<key>name</key>
+			<string>entity.name.function.nucleotides</string>
+		</dict>
+		<dict>
+			<key>comment</key>
+			<string>thymine</string>
+			<key>match</key>
+			<string>T</string>
+			<key>name</key>
+			<string>constant.numeric.source.nucleotides</string>
+		</dict>
+		<dict>
+			<key>comment</key>
+			<string>guanine</string>
+			<key>match</key>
+			<string>G</string>
+			<key>name</key>
+			<string>string.quoted.source.nucleotides</string>
+		</dict>
+		<dict>
+			<key>comment</key>
+			<string>unknown</string>
+			<key>match</key>
+			<string>N</string>
+			<key>name</key>
+			<string>comment.block.source.nucleotides</string>
+		</dict>
+	</array>
+	<key>scopeName</key>
+	<string>source.nucleotides</string>
+	<key>uuid</key>
+	<string>34f308ec-03a9-428e-93dd-d8eae6648d7f</string>
+</dict>
+</plist>