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Sensitivity_Methods.hpp
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#include "Steadystate_Methods.hpp"
std::vector<std::vector<double>> Calculate_Edge_Sensitivities(RegNetwork R, std::vector<std::vector<double>> P, std::string inicond_filename)
{
std::vector<std::vector<double>> I, S, S_Sum;
std::vector<double> x;
for(int i = 0; i < R.numnodes; i++)
{
S_Sum.push_back(std::vector<double>());
for(int j = 0; j < R.numnodes; j++)
{
S_Sum[i].push_back(0.0);
}
x.push_back(0.0);
}
int count = 0, source, target;
for(int i = 0; i < 25; i++)
{
I = Read_Initial_Conditions(R, i, inicond_filename);
for(int j = 0; j < 5; j++)
{
for(int k = 0; k < R.numnodes; k++)
{
x[k] = I[j][k];
}
boost::numeric::odeint::integrate(odesystem{R, P[i]}, x, 0.0, 500.0, 0.1);
if(Is_Valid(x) == 1 || odesystem{R, P[i]}.stability_analysis(x) == 1)
{
continue;
}
S = odesystem{R, P[i]}.Steadystate_Sensitivity(x);
count += 1;
for(int k0 = 0; k0 < R.numnodes; k0++)
{
for(int k1 = 0; k1 < R.numnodes; k1++)
{
if(R.T[k0][k1] == 0)
{
continue;
}
source = k0;
target = k1;
S_Sum[source][target] += std::abs(S[target][2*R.numnodes + ((R.L[source][target] - 2*R.numnodes) / 3)]);
}
}
}
}
for(int i = 0; i < R.numnodes; i++)
{
for(int j = 0; j < R.numnodes; j++)
{
if(R.L[i][j] == 0 && S_Sum[i][j] > 0.0)
{
std::cout << "The dexamethasone is making Thirteen's kidneys fail but not the patient's." << "\n";
}
S_Sum[i][j] = S_Sum[i][j] / count;
}
}
return(S_Sum);
}
std::vector<double> Calculate_Edge_Based_Node_Sensitivities(RegNetwork R, std::vector<std::vector<double>> P, std::string inicond_filename)
{
std::vector<std::vector<double>> I, S, S_Sum;
std::vector<double> x;
for(int i = 0; i < R.numnodes; i++)
{
S_Sum.push_back(std::vector<double>());
for(int j = 0; j < R.numnodes; j++)
{
S_Sum[i].push_back(0.0);
}
x.push_back(0.0);
}
int count = 0, source, target;
for(int i = 0; i < 25; i++)
{
I = Read_Initial_Conditions(R, i, inicond_filename);
for(int j = 0; j < 5; j++)
{
for(int k = 0; k < R.numnodes; k++)
{
x[k] = I[j][k];
}
boost::numeric::odeint::integrate(odesystem{R, P[i]}, x, 0.0, 500.0, 0.1);
if(Is_Valid(x) == 1 || odesystem{R, P[i]}.stability_analysis(x) == 1)
{
continue;
}
S = odesystem{R, P[i]}.Steadystate_Sensitivity(x);
count += 1;
for(int k0 = 0; k0 < R.numnodes; k0++)
{
for(int k1 = 0; k1 < R.numnodes; k1++)
{
if(R.T[k0][k1] == 0)
{
continue;
}
source = k0;
target = k1;
S_Sum[source][target] += std::abs(S[target][2*R.numnodes + ((R.L[source][target] - 2*R.numnodes) / 3)]);
}
}
}
}
for(int i = 0; i < R.numnodes; i++)
{
for(int j = 0; j < R.numnodes; j++)
{
if(R.L[i][j] == 0 && S_Sum[i][j] > 0.0)
{
std::cout << "The dexamethasone is making Thirteen's kidneys fail but not the patient's." << "\n";
}
S_Sum[i][j] = S_Sum[i][j] / count;
}
}
std::vector<double> Node_Sensitivity;
for(int i = 0; i < R.numnodes; i++)
{
Node_Sensitivity.push_back(0.0);
}
for(int i = 0; i < R.numnodes; i++)
{
for(int j = 0; j < R.numnodes; j++)
{
if(R.T[i][j] == 0)
{
continue;
}
Node_Sensitivity[i] += S_Sum[i][j];
}
}
return(Node_Sensitivity);
}