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Acute lymphoblastic leukemia displays a distinct highly methylated genome

Description

This repository contains the scripts to reproduce the figures presented in Hetzel et. al. 2022 Nature Cancer. Source data required as input for these scripts are deposited at 10.5281/zenodo.6337435.

Data availability

WGBS data of primary ALL and normal samples as patient derived have been deposited in the European Genome Phenome archive (accession EGAS00001005203). WGBS of B-ALL and T-ALL cell lines as well as RNAseq data of the T-ALL cell lines DND41 and Jurkat have been deposited in the Gene Expression Omnibus under accession GSE164040.