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Fixes #2903 tuft cell of nasal cavity #2918

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Update cl-edit.owl
Caroline-99 committed Jan 27, 2025
commit 11a63ce9e01c9e86abd7688a54316b66f0cc338b
2 changes: 1 addition & 1 deletion src/ontology/cl-edit.owl
Original file line number Diff line number Diff line change
@@ -33555,7 +33555,7 @@ EquivalentClasses(obo:CL_4052035 ObjectIntersectionOf(obo:CL_0002204 ObjectSomeV

# Class: obo:CL_4052036 (tuft cell of nasal cavity)

AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:30379593") Annotation(oboInOwl:hasDbXref "PMID:38306414") obo:IAO_0000115 obo:CL_4052036 "A tuft cell that is part of the nasal cavity epithelium, located in both the respiratory and olfactory epithelia of the nose. It shares a core transcriptional profile with other tuft cells, including those in the trachea and intestine, expressing markers such as TRPM5, POU2F3, ChAT, AVIL, and eicosanoid biosynthetic enzymes like ALOX5AP and LTC4S. This cell plays key roles in chemosensation, lipid mediator production, immune responses, and epithelial homeostasis. It is more abundant in the nasal cavity than in the trachea.")
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:30379593") Annotation(oboInOwl:hasDbXref "PMID:38306414") obo:IAO_0000115 obo:CL_4052036 "A tuft cell that is part of the nasal cavity epithelium, located in both the respiratory and olfactory epithelia of the nose. This cell plays key roles in chemosensation, lipid mediator production, immune responses, and epithelial homeostasis. It shares a core transcriptional profile with other tuft cells but can be classified into subtypes based on specific marker expression and anatomical location within the nasal cavity.")
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  • We normally don't add characteristics (in this case markers) that define the parent class. Are there any specific markers?
  • The textual definition states that these cells are found in the trachea, therefore the formal definition is wrong. I understand that there are more tuft cells in the nasal cavity than in the trachea, but tuft cells of nasal cavity, which are restricted to nasal cavity. I would remove this sentence.

AnnotationAssertion(terms:contributor obo:CL_4052036 <https://orcid.org/0009-0000-8480-9277>)
AnnotationAssertion(terms:date obo:CL_4052036 "2025-01-21T09:04:03Z"^^xsd:dateTime)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:34692913") oboInOwl:hasExactSynonym obo:CL_4052036 "nasal brush cell")