[NTR]Epithelial stem cell of gut

[JABelfiore]

Please check that the term does not already exist by using the ontology search tool OLS:
https://www.ebi.ac.uk/ols4/ontologies/cl

Preferred term label
Epithelial stem cell of gut

Synonyms (add reference(s), please)
IESCs
PMID:24326621
Definition (free text, with reference(s), please. PubMed ID format is PMID:XXXXXX)
A type of stem cell located at the base of intestinal crypts. This cell is capable of self-renewal and multipotent differentiation into all intestinal epithelial cell types including enterocytes, goblet cells, enteroendocrine cells, and paneth cells. Expresses markers such as LGR5, ASCL2, SMOC2. Interacts with supportive Paneth cells in the stem cell niche. Rapidly dividing to maintain intestinal epithelial homeostasis[PMID:24326621][PMID:38835047].

Parent cell type term (check the hierarchy here https://www.ebi.ac.uk/ols4/ontologies/cl)
Epithelial fate stem cell

Anatomical structure where the cell type is found (check Uberon for anatomical structures: https://www.ebi.ac.uk/ols4/ontologies/uberon)
part of base of crypt of Lieberkuhn

Your ORCID
https://orcid.org/0009-0005-7919-4905

Additional notes or concerns

[dosumis]

Please make part relationships to anatomy as specific as possible. In this case - should be part of base of crypt of Lieberkuhn
http://purl.obolibrary.org/obo/UBERON_0013739

(Note this is already classified as epithelium)

[dosumis]

These are commonly known as IESCs - Intestinal epithelial stem cells. I would use this name and add the abbreviation.

"Epithelial fate stem cell" is very broad sounding - I don't think useful as synonym. Looks like it belongs on parent class.

Some suggested tweaks to def.

An epithelial stem cell located in a stem cell niche at the base of intestinal crypts. This cell is capable of self-renewal and multipotent differentiation into all intestinal epithelial cell types including enterocytes, goblet cells, enteroendocrine cells, and paneth cells. These cells divide rapidly to maintain epithelial homeostatis. A variety of adjacent cell types secrete signals that support and maintain the identity of this cell type in the niche, including Paneth Cells and specialised fibroblasts.

Expresses markers such as LGR5, ASCL2, SMOC2. <-- Make clear in what species these apply (ESP - Do they cover both mice and humans?)

[PMID:24326621][PMID:38835047].

Some more potential refs: PMID:22610555, https://doi.org/10.1038/s12276-024-01179-1

[dosumis]

Probably the same cell type as intestinal crypt stem cell http://purl.obolibrary.org/obo/CL_0002250

Supported by refs from perplexity queries here: https://www.perplexity.ai/search/describe-the-stcructure-functi-7WpJ4XtlSouAWm_2eYc2Ug