From aa831595d2bcfdfafad6bbf4ed6f7a04d8c8e906 Mon Sep 17 00:00:00 2001 From: CEastwood <116108977+Caroline-99@users.noreply.github.com> Date: Tue, 11 Feb 2025 10:45:09 +0000 Subject: [PATCH] Fixes #2929 - Intestinal tuft cell textual definition (#2935) Fixes #2929 - Improved Intestinal tuft cell textual definition - Added references The term 'cytospinule' has been added to GO and will be linked to this term once available. --- src/ontology/cl-edit.owl | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/src/ontology/cl-edit.owl b/src/ontology/cl-edit.owl index 01aaaac79..315fabb71 100644 --- a/src/ontology/cl-edit.owl +++ b/src/ontology/cl-edit.owl @@ -25005,7 +25005,7 @@ SubClassOf(obo:CL_0019031 ObjectSomeValuesFrom(obo:RO_0002202 obo:CL_4047017)) # Class: obo:CL_0019032 (intestinal tuft cell) -AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:22527717") Annotation(oboInOwl:hasDbXref "PMID:39358509") obo:IAO_0000115 obo:CL_0019032 "Any brush cell that is part of the intestinal epithelium.") +AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:22527717") Annotation(oboInOwl:hasDbXref "PMID:39358509") Annotation(oboInOwl:hasDbXref "PMID:29714721") Annotation(oboInOwl:hasDbXref "PMID:35237268") obo:IAO_0000115 obo:CL_0019032 "A tuft cell that is part of the intestinal epithelium, characterized by a distinctive apical tuft and lateral cytospinules connecting to neighbouring cells. This cell senses luminal stimuli via taste receptors and succinate signalling, initiating type 2 immune responses through the secretion of interleukin-25 while modulating epithelial regeneration through prostaglandin synthesis. It expresses key molecular markers such as doublecortin-like kinase 1 (DCLK1) in mice (Hendel et al., 2022), and KIT proto-oncogene in humans (Huang et al., 2024). Developed from intestinal crypt stem cells, this cell requires transcription factor POU2F3 for its development.") AnnotationAssertion(terms:contributor obo:CL_0019032 ) AnnotationAssertion(terms:date obo:CL_0019032 "2020-10-15T12:47:46Z"^^xsd:dateTime) AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:22527717") oboInOwl:hasExactSynonym obo:CL_0019032 "intestinal brush cell")