From 21ed80b57eef15d3d669421a7532f4d4afa331a6 Mon Sep 17 00:00:00 2001
From: bvarner-ebi <95643797+bvarner-ebi@users.noreply.github.com>
Date: Thu, 20 Jul 2023 08:59:55 +0100
Subject: [PATCH] release 2023-07-20
---
cl-base.owl | 657 +-
cl.obo | 1496 ++-
patterns/definitions.owl | 4 +-
src/ontology/diffs/cl-diff.md | 8096 ++++++++++-------
.../reports/cl-edit.owl-obo-report.tsv | 9 +-
.../subsets/blood_and_immune_upper_slim.json | 1062 ++-
.../subsets/blood_and_immune_upper_slim.obo | 314 +-
.../subsets/blood_and_immune_upper_slim.owl | 1144 ++-
.../subsets/blood_and_immune_upper_slim.tsv | 806 +-
src/ontology/subsets/eye_upper_slim.json | 1278 +--
src/ontology/subsets/eye_upper_slim.obo | 390 +-
src/ontology/subsets/eye_upper_slim.owl | 1988 ++--
src/ontology/subsets/eye_upper_slim.tsv | 668 +-
.../general_cell_types_upper_slim.json | 945 +-
.../subsets/general_cell_types_upper_slim.obo | 282 +-
.../subsets/general_cell_types_upper_slim.owl | 1034 ++-
.../subsets/general_cell_types_upper_slim.tsv | 568 +-
subsets/blood_and_immune_upper_slim.json | 1062 ++-
subsets/blood_and_immune_upper_slim.obo | 314 +-
subsets/blood_and_immune_upper_slim.owl | 1144 ++-
subsets/blood_and_immune_upper_slim.tsv | 806 +-
subsets/eye_upper_slim.json | 1278 +--
subsets/eye_upper_slim.obo | 390 +-
subsets/eye_upper_slim.owl | 1988 ++--
subsets/eye_upper_slim.tsv | 668 +-
subsets/general_cell_types_upper_slim.json | 945 +-
subsets/general_cell_types_upper_slim.obo | 282 +-
subsets/general_cell_types_upper_slim.owl | 1034 ++-
subsets/general_cell_types_upper_slim.tsv | 568 +-
29 files changed, 18174 insertions(+), 13046 deletions(-)
diff --git a/cl-base.owl b/cl-base.owl
index a0cc0f3ee..4757a968a 100644
--- a/cl-base.owl
+++ b/cl-base.owl
@@ -17,7 +17,7 @@
xmlns:ubprop="http://purl.obolibrary.org/obo/ubprop#"
xmlns:oboInOwl="http://www.geneontology.org/formats/oboInOwl#">
-
+
An ontology of cell types.
Cell Ontology
@@ -33,7 +33,7 @@
See PMID:15693950, PMID:12799354, PMID:20123131, PMID:21208450; Contact Alexander Diehl, addiehl@buffalo.edu, University at Buffalo.
- 2023-06-22
+ 2023-07-20
@@ -49,6 +49,12 @@
+
+
+
+
+
+
@@ -610,6 +616,12 @@
+
+
+
+
+
+
@@ -742,12 +754,6 @@
-
-
-
-
-
-
-
+
- A supportive cell of the vertebrate pituitary that provides macromolecular transport and secretes hormones.
+
+
+
+
+
+
+ An agranular supporting cell of the anterior pituitary (adenohypophysis) that is characterized by a star-like morphology and ability to form follicles. Folliculostellate cells communicate with each other and with endocrine cells via gap junctions.
+ folliculo-stellate cell
+ pituitary folliculostellate cell
+ FS cell
+ FSC
+ Sox2-positive stem cell
+ Folliculostellate cells are a heterogeneous group of cells rather than a single cell type, with different morphology and gene expression profiles. Due to this heterogeneity, it is unclear if different properties that have been attributed to folliculostellate cells (pluripotent, proliferative, phagocytic) are common in all folliculostellate cells or limited to particular subsets.
folliculostellate cell
- A supportive cell of the vertebrate pituitary that provides macromolecular transport and secretes hormones.
+ An agranular supporting cell of the anterior pituitary (adenohypophysis) that is characterized by a star-like morphology and ability to form follicles. Folliculostellate cells communicate with each other and with endocrine cells via gap junctions.
JB:jb
+ PMID:10495875
+ PMID:15961560
+ doi:10.23937/2572-407X.1510006
+
+
+
+
+ folliculo-stellate cell
+ doi:10.23937/2572-407X.1510006
+
+
+
+
+ pituitary folliculostellate cell
+ PMID:34734454
+
+
+
+
+ FS cell
+ PMID:34734454
+
+
+
+
+
+ FSC
+ doi:10.23937/2572-407X.1510006
+
+
+
+
+
+ Sox2-positive stem cell
+ PMID:34734454
+
+
+
+
+ Folliculostellate cells are a heterogeneous group of cells rather than a single cell type, with different morphology and gene expression profiles. Due to this heterogeneity, it is unclear if different properties that have been attributed to folliculostellate cells (pluripotent, proliferative, phagocytic) are common in all folliculostellate cells or limited to particular subsets.
+ PMID:18287078
+ PMID:31620083
+ PMID:34734454
+ doi:10.23937/2572-407X.1510006
@@ -20186,9 +20366,10 @@ radial glial cells acting as neural progenitors throughout life.
BTO:0001800
FMA:67765
MESH:D012165
- RGC
gangliocyte
ganglion cell of retina
+ RGC
+ RGCs
retinal ganglion cell
@@ -20199,6 +20380,21 @@ radial glial cells acting as neural progenitors throughout life.
The set of neurons that receives neural inputs via bipolar, horizontal and amacrine cells. The axons of these cells make up the optic nerve.
GOC:dph
+
+
+
+ RGC
+ doi:10.1038/s41598-020-66092-9
+
+
+
+
+
+ RGCs
+ doi:10.1038/s41598-020-66092-9
+
+
+
@@ -20295,6 +20491,8 @@ radial glial cells acting as neural progenitors throughout life.
BTO:0004120
horizontal cell
+ HC
+ HCs
retina horizontal cell
@@ -20305,6 +20503,21 @@ radial glial cells acting as neural progenitors throughout life.
A neuron that laterally connects other neurons in the inner nuclear layer of the retina.
ISBN:0195088433
+
+
+
+ HC
+ doi:10.1038/s41598-020-66092-9
+
+
+
+
+
+ HCs
+ doi:10.1038/s41598-020-66092-9
+
+
+
@@ -20409,7 +20622,7 @@ radial glial cells acting as neural progenitors throughout life.
-
+
@@ -20439,6 +20652,9 @@ radial glial cells acting as neural progenitors throughout life.
A bipolar neuron found in the retina and having connections with photoreceptors cells and neurons in the inner plexiform layer.
+ BC
+ BCs
+ BPs
retinal bipolar neuron
@@ -20449,6 +20665,29 @@ radial glial cells acting as neural progenitors throughout life.
A bipolar neuron found in the retina and having connections with photoreceptors cells and neurons in the inner plexiform layer.
PMID:14689473
+
+
+
+ BC
+ doi:10.1038/s41598-020-66092-9
+
+
+
+
+
+ BCs
+ doi:10.1038/s41598-020-66092-9
+
+
+
+
+
+
+ BPs
+ GSE137537
+
+
+
@@ -20456,12 +20695,6 @@ radial glial cells acting as neural progenitors throughout life.
-
-
-
-
-
-
A bipolar neuron found in the retina and having connections with photoreceptors cells and neurons in the inner half of the inner plexiform layer. These cells depolarize in response to light stimulation of their corresponding photoreceptors.
@@ -20597,7 +20830,7 @@ radial glial cells acting as neural progenitors throughout life.
-
+
@@ -20615,7 +20848,7 @@ radial glial cells acting as neural progenitors throughout life.
FMB cone bipolar cell
type 2 cone bipolar cell (sensu Mus)
-
+
@@ -20635,7 +20868,7 @@ radial glial cells acting as neural progenitors throughout life.
-
+
PMID:27565351
@@ -34484,22 +34717,38 @@ radial glial cells acting as neural progenitors throughout life.
-
- Granule cell that is part of the cerebellum.
+
+
+
+
+
+
+
+ An excitatory granule cell with a soma located in the granular layer of cerebellar cortex. A mature cerebellar granule cell has short dendrites with a characteristic claw-like appearance and a long axon that ascends to the molecular layer where it bifurcates (except in non-teleost fish, where it does not bifurcate) and extends mediolaterally to form parallel fibers.
BTO:0004278
+ granule cell of the cerebellum
+ It has been noted in at least some mammalian species that granule cells are the most numerous cell type in the cerebellum and in the brain, with at least 99% of all cerebellar neurons being granule cells.
cerebellar granule cell
-
-
- true
+
+ An excitatory granule cell with a soma located in the granular layer of cerebellar cortex. A mature cerebellar granule cell has short dendrites with a characteristic claw-like appearance and a long axon that ascends to the molecular layer where it bifurcates (except in non-teleost fish, where it does not bifurcate) and extends mediolaterally to form parallel fibers.
+ GOC:mah
+ doi:10.12688/f1000research.15021.1
+ doi:10.3389/fncir.2020.611841
-
- Granule cell that is part of the cerebellum.
- GOC:mah
+
+ granule cell of the cerebellum
+ doi:10.3389/fncir.2020.611841
+
+
+
+
+ It has been noted in at least some mammalian species that granule cells are the most numerous cell type in the cerebellum and in the brain, with at least 99% of all cerebellar neurons being granule cells.
+ doi:10.3389/fncir.2020.611841
@@ -47812,7 +48061,7 @@ radial glial cells acting as neural progenitors throughout life.
-
+
@@ -47827,14 +48076,14 @@ radial glial cells acting as neural progenitors throughout life.
Type A cells are usually round and located in the upper part of the synovial intima.
type A synovial cell
-
+
-
+
PMID:10770586
@@ -49900,18 +50149,46 @@ radial glial cells acting as neural progenitors throughout life.
- A cell located in the outermost proliferative zone of the external germinal layer that can differentiate into astroglial cells and granule cells. This cell type is glial fibrillary acidic protein-positive and NK1-positive.
+
+
+
+
+
+
+ A cell located in the outermost proliferative zone of the external germinal layer that can differentiate into astroglial cells and granule cells. This cell type is glial fibrillary acidic protein-positive and HNK1-positive.
2010-09-22T01:40:44Z
- granule cell precursor
+ granule cell precursor
+ granule cell progenitor
+ GCP
+ cerebellar granule cell precursor
- A cell located in the outermost proliferative zone of the external germinal layer that can differentiate into astroglial cells and granule cells. This cell type is glial fibrillary acidic protein-positive and NK1-positive.
+ A cell located in the outermost proliferative zone of the external germinal layer that can differentiate into astroglial cells and granule cells. This cell type is glial fibrillary acidic protein-positive and HNK1-positive.
GOC:tfm
PMID:14745007
+
+
+
+ granule cell precursor
+ doi:10.3389/fncir.2020.611841
+
+
+
+
+ granule cell progenitor
+ doi:10.3389/fncir.2020.611841
+
+
+
+
+ GCP
+ doi:10.3389/fncir.2020.611841
+
+
@@ -62700,6 +62977,7 @@ radial glial cells acting as neural progenitors throughout life.
https://orcid.org/0000-0002-5260-9315
A Horizontal Cell
cell
+ H1
CL:0004217
H1 horizontal cell
@@ -62709,6 +62987,13 @@ radial glial cells acting as neural progenitors throughout life.
A horizontal cell with a large cell body, thick dendrites, and a large dendritic arbor.
PMID:8571130
+
+
+
+ H1
+ doi:10.1038/s41598-020-66092-9
+
+
@@ -62727,6 +63012,7 @@ radial glial cells acting as neural progenitors throughout life.
https://orcid.org/0000-0002-5260-9315
B Horizontal Cell
cell
+ H2
CL:0004218
H2 horizontal cell
@@ -62736,6 +63022,13 @@ radial glial cells acting as neural progenitors throughout life.
A horizontal cell with a small cell body, thin dendrites, and small dendritic arbor.
PMID:8571130
+
+
+
+ H2
+ doi:10.1038/s41598-020-66092-9
+
+
@@ -65612,18 +65905,18 @@ Covers cells actively being cultured or stored in a quiescent state for future u
-
+
A skeletal muscle satellite cell that has become mitotically active - typically following muscle damage.
activated skeletal muscle satellite cell
-
+
-
+
More accurately - transformation_of ?
@@ -68948,6 +69241,12 @@ Covers cells actively being cultured or stored in a quiescent state for future u
+
+
+
+
+
+
An endothelial cell that is part of a respiratory system lymphatic vessel.
@@ -88064,26 +88363,34 @@ plexiform layer using GABA.
-
+
-
+
- The principal cell type of the dentate gyrus.
+ A granule cell that has soma location in the dentate gyrus cell layer of the hippocampal formation and has an elliptical cell body and characteristic cone-shaped tree of spiny apical dendrites. The branches extend throughout the molecular layer and the distal tips of the dendritic tree end just at the hippocampal fissure or at the ventricular surface. The dentate gyrus granule cell is the principal cell type of the dentate gyrus.
2015-02-23T05:48:23Z
+ dentate gyrus of hippocampal formation granule cell
CL:2000089
- The granule cell has a characteristic cone-shaped tree of spiny apical dendrites.
- dentate gyrus of hippocampal formation granule cell
+ As far as can be determined, all dentate granule cells appear to project to CA3 and the axon trajectory is partially correlated with the position of the parent cell body.
+ dentate gyrus granule cell
- The principal cell type of the dentate gyrus.
+ A granule cell that has soma location in the dentate gyrus cell layer of the hippocampal formation and has an elliptical cell body and characteristic cone-shaped tree of spiny apical dendrites. The branches extend throughout the molecular layer and the distal tips of the dendritic tree end just at the hippocampal fissure or at the ventricular surface. The dentate gyrus granule cell is the principal cell type of the dentate gyrus.
GOC:TermGenie
+ PMID:17765709
+
+
+
+
+ As far as can be determined, all dentate granule cells appear to project to CA3 and the axon trajectory is partially correlated with the position of the parent cell body.
+ PMID:17765709
@@ -88689,6 +88996,7 @@ plexiform layer using GABA.
+ L2/3 bipolar vip interneuron (Mus)
A vip GABAergic cortical interneuron with bipolar morphology, with a soma found in L2/3. L2/3 bipolar vip cells have extending axons across all layers (with preferences for layers II/III and Va) and a dendritic tree that is vertically more restricted than deeper layer vip cells and extend fewer dendrites into the layers outside their home layer (location of soma). L2/3 bipolar vip cells have great variability in firing patterns, though most are continuous adapting. L2/3 bipolar vip cells are more depolarized in their resting state, had less fast rectification, and had smaller after hyperpolarization than deeper vip cells.
L2/3 bipolar Vip (Mus musculus)
@@ -88722,6 +89030,7 @@ plexiform layer using GABA.
+ IT glut
A glutamatergic neuron located in the cerebral cortex that projects to structures of telencephalic origins.
@@ -88758,6 +89067,7 @@ plexiform layer using GABA.
+ ET glut
A glutamatergic neuron located in the cerebral cortex that projects to structures not derived from telencephalon.
@@ -88804,6 +89114,7 @@ plexiform layer using GABA.
+ A7 interneuron
A GABAergic cortical interneuron that is strongly labelled for α7 nAChRs. These cells have soma found in L1 and have multipolar dendrites with vertically descending axonal collaterals that project deep into the column, usually branching and terminating in L5A.
A7 cell (Mus musculus)
@@ -88851,6 +89162,7 @@ plexiform layer using GABA.
+ Lamp5 cortical interneuron
A GABAergic neuron located in the cerebral cortex that expresses Lamp5
ILX:0770149
@@ -88884,6 +89196,7 @@ plexiform layer using GABA.
+ NP glut neuron
A glutamatergic neuron located in the cerebral cortex that projects axons locally rather than distantly.
@@ -88920,6 +89233,7 @@ plexiform layer using GABA.
+ CT glut
A glutamatergic neuron located in the cerebral cortex that projects to the thalamus.
CT projecting neuron
@@ -88963,6 +89277,7 @@ plexiform layer using GABA.
+ L5 vip interneuron (Mus)
A vip GABAergic cortical interneuron with a soma found in L5. L5 vip cells have mostly local morphology with some deep-projecting axons. They show only moderate resistance, comparable to that of sst subclass and unlike typical Vip subclass cells that tend to show high input resistance. L5 vip cells show particularly low resting membrane potential.
L5 VIP (Mus musculus)
@@ -89001,6 +89316,7 @@ plexiform layer using GABA.
+ sncg cortical interneuron
A GABAergic neuron located in the cerebral cortex that expresses Gamma-synuclein
ILX:0770150
@@ -89038,6 +89354,7 @@ plexiform layer using GABA.
+ vip cortical interneuron
A GABAergic neuron located in the cerebral cortex that expresses vasoactive intestinal polypeptide
ILX:0770151
@@ -89075,6 +89392,7 @@ plexiform layer using GABA.
+ sst cortical interneuron
A GABAergic neuron located in the cerebral cortex that expresses somatostatin (sst)
ILX:0770152
@@ -89112,6 +89430,7 @@ plexiform layer using GABA.
+ pvalb cortical interneuron
A GABAergic interneuron located in the cerebral cortex that expresses Parvalbumin.
ILX:0770154
@@ -89234,6 +89553,7 @@ plexiform layer using GABA.
+ canopy lamp5 interneuron
A Lamp5 GABAergic cortical interneuron that has extended axons in the surface of L1. Canopy Lamp5 cells resemble neurogliaform cells in having elongated horizontal axonal arbors largely confined to L1; but the dendritic arbors are wider and have fewer branches, while the axon is less tortuous and extends further from the soma
@@ -89282,6 +89602,7 @@ plexiform layer using GABA.
+ L5,6 NGC Lamp5 interneuron (Mus)
A lamp 5 GABAergic cortical interneuron with neurogliaform morphology with a soma found in L5,6. L5,6 NGC lamp5 have deep afterhyperpolarization (AHP) but narrow action potentials (APs). Unlike other deep neurogliaform cells (which are caudal ganglionic eminence (CGE) derived), L5,6 NGC lamp5 cells are medial ganglionic eminence (MGE)-derived
L5,6 NGC Lamp5 (Mus musculus)
@@ -89331,6 +89652,7 @@ plexiform layer using GABA.
+ NGC Lamp5 interneuron (Mus)
A lamp5 GABAergic cortical interneuron with layer-adapting morphology. NGC lamp5 cells have a small round soma, short dendrites, and a wide dense axonal arbor that tends to establish a dense axonal mesh with high connection probability both to themselves and L2 pyramidal cells. NGC lamp5 cells have unique synaptic properties that distinguish them from other GABAergic interneurons, including the release of GABA to the extracellular space via volume transmission, and the ability to produce GABA-B responses in connected postsynaptic targets.
NGC Lamp5 (Mus musculus)
@@ -89476,6 +89798,7 @@ plexiform layer using GABA.
+ L5 T Martinotti sst interneuron (Mus)
A sst GABAergic cortical interneuron with a soma found in L5 and possesses 'T-shaped' Martinotti morphologies with local axonal plexus in L5a and translaminar axons restricted to the uppermost part of L1. They show low-threshold spiking patterns with strong rebound firing, and inhibit the L1 apical tuft of nearby pyramidal cells.
L5 T Martinotti SST (Mus musculus)
@@ -89520,6 +89843,7 @@ plexiform layer using GABA.
+ L5 non-Martinotti sst interneuron (Mus)
A sst GABAergic cortical interneuron with a soma found in lower L5 with mostly local axonal arborization but with some sparse ascending axons. L5 non-Martinotti sst cells show somatic localization and local axon plexus in L5b and L5b/6 and substantial innervation of L3 and L4, and receive thalamic input from the ventral posteromedial nucleus and specifically target L4 neurons, avoiding L5 pyramidal cells. L5 non-Martinotti sst cells tend to show a higher input resistance and seem to be less stuttering.
L5 non-Martinotti SST (Mus musculus)
@@ -89617,6 +89941,7 @@ plexiform layer using GABA.
+ L2/3/5 fan Martinotti sst interneuron (Mus)
A sst GABAergic cortical interneuron that has "fanning-out' Martinotti morphology that is found in layer 2/3/5 of the cerebral cortex. They have local axon arbor and long ascending axons that spreads horizontally and arborizes significantly in L1.
L2/3/5 fan Martinotti SST (Mus musculus)
@@ -89676,6 +90001,7 @@ plexiform layer using GABA.
+ L4 sst interneuron (Mus)
A sst GABAergic cortical interneuron with a soma found in lower L2/3 and upper 5, L4 Sst cells have Martinotti morphology with ascending axons but denser local axons and sparser ‘fanning-out’ projections to L1. L4 sst cells have smaller membrane time constant to calb2 (L2/3/5 fan Martinotti Cell) and non-zero afterdepolarization (ADP).
L4 SST (Mus musculus)
@@ -89773,6 +90099,7 @@ plexiform layer using GABA.
+ chandelier PV interneuron
A pvalb GABAergic cortical interneuron that is recognizable by the straight terminal axonal 'cartridges' of vertically oriented strings of synaptic boutons. Chandelier PV cells' boutons target exclusively the axon initial segment (AIS) of pyramidal cells, with a single cell innervating hundreds of pyramidal cells in a clustered manner.
ILX:0107356
@@ -89810,6 +90137,7 @@ plexiform layer using GABA.
+ L6b glut
A glutamatergic neuron with a soma found in cortical layer 6b. They are transcriptomically related to corticothalamic-projecting neurons but have differential projections to the thalamus or anterior cingulate.
ILX:0770163
@@ -89863,6 +90191,7 @@ plexiform layer using GABA.
+ L2/3-6 IT glut
A intratelencephalic-projecting glutamatergic neuron with a soma found in cortical layers L2/3-6
L2/3-6 IT projecting neuron
@@ -89898,6 +90227,7 @@ plexiform layer using GABA.
+ L5 ET glut
A glutamatergic neuron, with a soma found in the deeper portion of L5, that has long-range axonal projections including deep subcortical targets outside of the telencephalon and, in some cases, the spinal cord. While the L5 ET neuron projections are not limited to ET targets, they are clearly differentiated from the neuron subclasses whose projections are constrained to intratelencephalic (IT) targets. L5 ET neurons are generally the largest excitatory cortical neurons, typically having a thick apical dendrite with a prominent dendritic tuft in layer 1 and displaying burst-firing physiological characteristics.
L5b neuron
@@ -89975,6 +90305,7 @@ plexiform layer using GABA.
+ L6 CT glut
A corticothalamic-projecting neuron with a soma found in cortical layer 6.
L6 CT
@@ -90008,6 +90339,7 @@ plexiform layer using GABA.
+ L5/6 NP glut MOp
A near-projecting glutamatergic neuron with a soma found in layer 5/6 of the primary motor cortex.
ILX:0770161
@@ -90036,6 +90368,7 @@ plexiform layer using GABA.
+ non-MY ET glut MOp
An extratelencephalic-projecting glutamatergic neuron located in layer 5b of the primary motor cortex that does not project to the medulla. Non-MY ET cells are large, big-tufted cells with the apical dendrite often bifurcating close to the soma, suggesting they are corticospinal cells. Non-MY ET cells have bigger hyperpolarization sag, lower input resistance, and smaller AP width, compared to L5 IT neurons.
non-MY ET M1
@@ -90076,6 +90409,7 @@ plexiform layer using GABA.
+ MY ET glut MOp
An extratelencephalic-projecting glutamatergic neuron located in layer 5b of the primary motor cortex that projects to the medulla. MY ET cells are large, big-tufted cells with the apical dendrite often bifurcating close to the soma, suggesting they are corticospinal cells. MY ET cells have bigger hyperpolarization sag, lower input resistance, and smaller AP width, compared to L5 IT neurons.
MY ET M1
@@ -90105,6 +90439,7 @@ plexiform layer using GABA.
+ L6b subplate glut
An excitatory glutamatergic neuron transcriptomically related to the CT subclass, with a soma preferentially located in the bottom of L6 of the primary motor cortex.
@@ -90137,6 +90472,7 @@ plexiform layer using GABA.
+ L2/3 IT glut MOp
An intratelencephalic-projecting glutamatergic neuron with a soma found in cortical layer 2/3.
L2/3 IT M1
@@ -90171,6 +90507,7 @@ plexiform layer using GABA.
+ L4/5 IT glut MOp
An intratelencephalic-projecting glutamatergic with a soma located in upper L5 of the primary motor cortex. These cells have thin untufted apical dendrites.
ILX:0770174
@@ -90206,6 +90543,7 @@ plexiform layer using GABA.
+ L5 IT glut MOp
An intratelencephalic-projecting glutamatergic neuron with a soma found in L5 of the primary motor cortex.
ILX:0770157
@@ -90247,6 +90585,7 @@ plexiform layer using GABA.
+ L6 IT glut MOp
An intratelencephalic-projecting glutamatergic neuron with a soma found in L6 of the primary motor cortex. These cells are short untufted pyramidal cells, which could be stellate or inverted.
ILX:0770158
@@ -90389,6 +90728,7 @@ plexiform layer using GABA.
+ CT VAL/VM glut MOp
A corticothalamic-projecting glutamatergic neuron that is located in L6 and lower L5 of the primary motor cortex, with a pyramidal morphology and mostly untufted apical dendrites terminating in midcortical layers. CT VAL/VM (ventroanterior-ventrolateral complex/ventromedial nucleus) cells have a near tonic firing pattern and are distinguished from L6 IT neurons by a lower inter-spike interval adaptation index.
CT VAL/VM M1
@@ -90416,43 +90756,43 @@ plexiform layer using GABA.
-
-
-
+
+
+
A type of mouse mesothelial fibroblast that is derived from the neural crest, is localized on blood vessels, and is a key component of the pia and arachnoid membranes surrounding the brain.
VLMC (Mus musculus)
vascular leptomeningeal cell (Mmus)
-
+
-
+
-
+
-
+
PMID:30096314
-
+
PMID:30096314
-
+
PMID:30096314
@@ -90636,6 +90976,7 @@ plexiform layer using GABA.
+ MGE interneuron
An interneuron that is derived from the medial ganglionic eminence.
@@ -90666,6 +91007,7 @@ plexiform layer using GABA.
+ CGE interneuron
An interneuron that is derived from the caudal ganglionic eminence.
@@ -90698,6 +91040,7 @@ plexiform layer using GABA.
+ meis2 GABA
A GABAergic cell located in the cerebral cortex that expresses meis2.
@@ -90815,6 +91158,7 @@ plexiform layer using GABA.
+ MGE cortical gaba interneuron
A GABAergic cortical interneuron that develops from the medial ganglionic eminence and has migrated to the cerebral cortex.
MGE cortical interneuron
@@ -90851,6 +91195,7 @@ plexiform layer using GABA.
+ CGE gaba cortical interneuron
A GABAergic cortical interneuron that develops from the caudal ganglionic eminence and has migrated to the cerebral cortex.
CGE cortical interneuron
@@ -90893,6 +91238,7 @@ plexiform layer using GABA.
+ L5/6 cck interneuron (Mus)
A GABAergic cortical interneuron that expresses cck. L5/6 cck cells have soma found mainly in L5 and L6 and have large axonal arborization.
L5/6 CCK (Mus musculus)
@@ -91029,6 +91375,7 @@ plexiform layer using GABA.
+ L6 th sst interneuron (Mus)
A sst GABAergic cortical interneuron found in L6 that expresses tyrosine hydroxylase. L6 Th+ SST cells have mostly local axonal arborization within L6.
L6 Th+ SST (Mus musculus)
@@ -91173,6 +91520,7 @@ plexiform layer using GABA.
+ stellate L6 IT glut MOp
a L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex that has stellate pyramidal morphology.
stellate L6 IT MOp (Mus musculus)
@@ -91198,6 +91546,7 @@ plexiform layer using GABA.
+ inverted L6 IT glut MOp
a L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex that has inverted pyramidal morphology.
inverted L6 IT MOp (Mus musculus)
@@ -92103,6 +92452,7 @@ plexiform layer using GABA.
+ L5/6 non-Martinotti sst interneuron (Mus)
A sst GABAergic interneuron does not have Martinotti morphology with a soma found in L5/6 of the cerebral cortex.
L5/6 non-Martinotti SST (Mus musculus)
@@ -92216,6 +92566,7 @@ plexiform layer using GABA.
+ sst chodl cortical interneuron
A sst GABAergic cortical interneuron that also expresses Chodl. These neurons are rare and correspond to the only known cortical interneurons with long-range projection.
long-range GABAergic interneuron
@@ -92626,20 +92977,20 @@ plexiform layer using GABA.
-
-
+
+
-
+
-
-
+
+
A neuron of the dorsal cochlear nucleus with spiny dendrites that receive input from the axons of granule cells and with axons that release GABA and glycine onto cartwheel, pyramidal and giant cell targets.
@@ -93030,6 +93381,12 @@ Midget bipolar cells (imb, fmb) have larger axon terminals at greater distances
+
+
+
+
+
+
Any capillary endothelial cell that is part of a lung.
2021-11-23T02:31:40Z
@@ -95381,7 +95738,7 @@ Midget bipolar cells (imb, fmb) have larger axon terminals at greater distances
https://orcid.org/0000-0003-3065-9183
2023-06-16T07:53:43Z
FMA:84155
-
urothelial intermediate cell
+ urothelial intermediate cell
It has been noted in at least some mammalian species that the urothelial intermediate cell type is similar to basal cells by expressing CK17 and (unlike umbrella cells) p63 but is positive for uroplakins (UPK) and negative for CK5. Urothelial intermediate cells have also been noted to be larger in diameter than urothelial basal cells.
intermediate cell of urothelium
@@ -95394,7 +95751,7 @@ Midget bipolar cells (imb, fmb) have larger axon terminals at greater distances
-
urothelial intermediate cell
+ urothelial intermediate cell
doi:10.1007/978-3-030-14366-4_8
@@ -95446,6 +95803,63 @@ Midget bipolar cells (imb, fmb) have larger axon terminals at greater distances
+
+
+
+
+ A medium spiny neuron that exhibits transcriptional divergence from direct and indirect spiny projection neurons, for example, enrichment in Casz1, Otof, Cacng5 and Pcdh8 noted in mice. Whilst in general medium spiny neurons have been found to be differentially distributed across the basal ganglia, the eccentric medium spiny neuron cell type has been found to be more evenly distributed throughout cerebral nuclei.
+ 2023-06-23T14:59:36Z
+ eccentric spiny projection neuron
+ eSPN
+ eccentric MSN
+ eccentric SPN
+ The term “eccentric” is used in the name eccentric medium spiny neuron (MSN) due to the exhibited transcriptional divergence from canonical spiny projection neurons. It has been noted in at least one study that an eccentric MSN differs in expression from direct and indirect MSNs by 110 genes (more than the 68 that distinguished direct and indirect spiny projection neurons from each other) and expresses many genes that have little expression in the rest of the striatum. It also has been noted in at least one human study that most eccentric MSNs expressed only DRD1, but many in the basal ganglia co-expressed DRD1 and DRD2, suggesting regional specialization of a more broadly distributed cell type.
+ eccentric medium spiny neuron
+
+
+
+
+ A medium spiny neuron that exhibits transcriptional divergence from direct and indirect spiny projection neurons, for example, enrichment in Casz1, Otof, Cacng5 and Pcdh8 noted in mice. Whilst in general medium spiny neurons have been found to be differentially distributed across the basal ganglia, the eccentric medium spiny neuron cell type has been found to be more evenly distributed throughout cerebral nuclei.
+ doi:10.1016/j.cell.2018.07.028
+ doi:10.1101/2022.10.12.511898
+
+
+
+
+ eccentric spiny projection neuron
+ doi:10.1016/j.cell.2018.07.028
+
+
+
+
+ eSPN
+ doi:10.1016/j.cell.2018.07.028
+
+
+
+
+
+ eccentric MSN
+ doi:10.1101/2022.10.12.511898
+
+
+
+
+
+ eccentric SPN
+ doi:10.1016/j.cell.2018.07.028
+
+
+
+
+
+ The term “eccentric” is used in the name eccentric medium spiny neuron (MSN) due to the exhibited transcriptional divergence from canonical spiny projection neurons. It has been noted in at least one study that an eccentric MSN differs in expression from direct and indirect MSNs by 110 genes (more than the 68 that distinguished direct and indirect spiny projection neurons from each other) and expresses many genes that have little expression in the rest of the striatum. It also has been noted in at least one human study that most eccentric MSNs expressed only DRD1, but many in the basal ganglia co-expressed DRD1 and DRD2, suggesting regional specialization of a more broadly distributed cell type.
+ doi:10.1016/j.cell.2018.07.028
+ doi:10.1101/2022.10.12.511898
+
+
+
+
@@ -96121,6 +96535,12 @@ Midget bipolar cells (imb, fmb) have larger axon terminals at greater distances
+
+
+
+
+
+
A smooth muscle cell that is part of a bronchiole.
@@ -96142,12 +96562,26 @@ Midget bipolar cells (imb, fmb) have larger axon terminals at greater distances
+
+
+
+
+
+
+
+
+
+
+
A megakaryocyte that is resident in the lung connective tissue.
2023-03-16T11:31:23Z
+ lung resident megakaryocyte
+ lung-resident megakaryocyte
+ MKL
lung MKs
lung megakaryocyte
@@ -96158,6 +96592,25 @@ Midget bipolar cells (imb, fmb) have larger axon terminals at greater distances
A megakaryocyte that is resident in the lung connective tissue.
PMID:33351116
+
+
+
+ lung resident megakaryocyte
+ PMID:36524131
+
+
+
+
+ lung-resident megakaryocyte
+ PMID:36524131
+
+
+
+
+ MKL
+ PMID:36524131
+
+
@@ -99244,6 +99697,12 @@ Midget bipolar cells (imb, fmb) have larger axon terminals at greater distances
+
+
+
+
+
+
@@ -103594,6 +104053,12 @@ Midget bipolar cells (imb, fmb) have larger axon terminals at greater distances
+
+
+
+
+
+
@@ -103804,6 +104269,12 @@ Midget bipolar cells (imb, fmb) have larger axon terminals at greater distances
+
+
+
+
+
+
@@ -104200,6 +104671,12 @@ Midget bipolar cells (imb, fmb) have larger axon terminals at greater distances
+
+
+
+
+
+
@@ -104680,6 +105157,12 @@ Midget bipolar cells (imb, fmb) have larger axon terminals at greater distances
+
+
+
+
+
+
@@ -104974,6 +105457,12 @@ Midget bipolar cells (imb, fmb) have larger axon terminals at greater distances
+
+
+
+
+
+
@@ -105256,27 +105745,17 @@ Midget bipolar cells (imb, fmb) have larger axon terminals at greater distances
-
+
-
+
-
+
-
-
-
-
-
-
-
-
-
-
diff --git a/cl.obo b/cl.obo
index 03458a63d..9ef47859d 100644
--- a/cl.obo
+++ b/cl.obo
@@ -1,5 +1,5 @@
format-version: 1.2
-data-version: releases/2023-06-22
+data-version: releases/2023-07-20
subsetdef: abnormal_slim ""
subsetdef: added_for_HCA ""
subsetdef: attribute_slim ""
@@ -82,7 +82,7 @@ synonymtypedef: INCONSISTENT ""
synonymtypedef: IUPAC_NAME ""
synonymtypedef: LATIN ""
synonymtypedef: LATIN "latin term"
-synonymtypedef: MISSPELLING ""
+synonymtypedef: MISSPELLING "a mis-spelling that is in common use and thus recorded"
synonymtypedef: NON_MAMMAL ""
synonymtypedef: PENDING_REVIEW ""
synonymtypedef: PLURAL "plural term"
@@ -109,7 +109,7 @@ property_value: dc-description "An ontology of cell types." xsd:string
property_value: dc-title "Cell Ontology" xsd:string
property_value: dcterms-license http://creativecommons.org/licenses/by/4.0/
property_value: has_ontology_root_term CL:0000000
-property_value: owl:versionInfo "2023-06-22" xsd:string
+property_value: owl:versionInfo "2023-07-20" xsd:string
[Term]
id: BFO:0000002
@@ -127,7 +127,8 @@ relationship: part_of BFO:0000003 {all_only="true"} ! occurrent
[Term]
id: BFO:0000004
name: independent continuant
-def: "A continuant that is a bearer of quality and realizable entity entities, in which other entities inhere and which itself cannot inhere in anything." []
+def: "b is an independent continuant = Def. b is a continuant which is such that there is no c and no t such that b s-depends_on c at t. (axiom label in BFO2 Reference: [017-002])" []
+comment: A continuant that is a bearer of quality and realizable entity entities, in which other entities inhere and which itself cannot inhere in anything.
is_a: BFO:0000002 ! continuant
disjoint_from: BFO:0000020 ! specifically dependent continuant
disjoint_from: BFO:0000031 ! generically dependent continuant
@@ -141,7 +142,8 @@ is_a: BFO:0000141 ! immaterial entity
[Term]
id: BFO:0000015
name: process
-def: "An occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t." []
+def: "p is a process = Def. p is an occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t. (axiom label in BFO2 Reference: [083-003])" []
+comment: An occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t.
is_a: BFO:0000003 ! occurrent
[Term]
@@ -167,7 +169,8 @@ relationship: part_of BFO:0000019 {all_only="true"} ! quality
[Term]
id: BFO:0000020
name: specifically dependent continuant
-def: "A continuant that inheres in or is borne by other entities. Every instance of A requires some specific instance of B which must always be the same." []
+def: "b is a specifically dependent continuant = Def. b is a continuant & there is some independent continuant c which is not a spatial region and which is such that b s-depends_on c at every time t during the course of b’s existence. (axiom label in BFO2 Reference: [050-003])" []
+comment: A continuant that inheres in or is borne by other entities. Every instance of A requires some specific instance of B which must always be the same.
is_a: BFO:0000002 ! continuant
disjoint_from: BFO:0000031 ! generically dependent continuant
relationship: part_of BFO:0000020 {all_only="true"} ! specifically dependent continuant
@@ -182,7 +185,8 @@ equivalent_to: CHEBI:50906
[Term]
id: BFO:0000031
name: generically dependent continuant
-def: "A continuant that is dependent on one or other independent continuant bearers. For every instance of A requires some instance of (an independent continuant type) B but which instance of B serves can change from time to time." []
+def: "b is a generically dependent continuant = Def. b is a continuant that g-depends_on one or more other entities. (axiom label in BFO2 Reference: [074-001])" []
+comment: A continuant that is dependent on one or other independent continuant bearers. For every instance of A requires some instance of (an independent continuant type) B but which instance of B serves can change from time to time.
is_a: BFO:0000002 ! continuant
relationship: part_of BFO:0000031 {all_only="true"} ! generically dependent continuant
@@ -338,14 +342,6 @@ is_a: CARO:0001008 ! gross anatomical part
disjoint_from: CARO:0010000 ! multicellular anatomical structure
property_value: IAO:0000118 "multi-cell-component structure" xsd:string
-[Term]
-id: CARO:0001001
-name: neuron projection bundle
-def: "A fasciculated bundle of neuron projections (GO:0043005), largely or completely lacking synapses." []
-is_a: CARO:0001000 ! multi-cell-part structure
-relationship: bearer_of PATO:0002309 ! fiber shaped
-property_value: IAO:0000118 "nerve fiber bundle" xsd:string {http://purl.obolibrary.org/obo/IAO_scope="EXACT"}
-
[Term]
id: CARO:0001008
name: gross anatomical part
@@ -774,7 +770,6 @@ xref: EMAPA:31484
xref: FBbt:00004936
xref: FMA:84049
xref: WBbt:0006799
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:0000015 {is_inferred="true"} ! male germ cell
is_a: CL:0000548 ! animal cell
intersection_of: CL:0000015 ! male germ cell
@@ -793,7 +788,6 @@ xref: EMAPA:31486
xref: FBbt:00004942
xref: FMA:72294
xref: WBbt:0006800
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:0000015 {is_inferred="true"} ! male germ cell
is_a: CL:0000413 ! haploid cell
is_a: CL:0000548 ! animal cell
@@ -820,7 +814,6 @@ xref: CALOHA:TS-0949
xref: FBbt:00004954
xref: FMA:67338
xref: WBbt:0006798
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:0000408 {is_inferred="true"} ! male gamete
relationship: develops_from CL:0000018 ! spermatid
@@ -885,7 +878,6 @@ id: CL:0000024
name: oogonial cell
def: "An undifferentiated germ cell that proliferates rapidly and gives rise to oocytes." [GOC:tfm, ISBN:0721662544]
xref: FMA:83673
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:0000021 {is_inferred="true"} ! female germ cell
is_a: CL:0000548 ! animal cell
intersection_of: CL:0000021 ! female germ cell
@@ -906,7 +898,6 @@ xref: FBbt:00057012
xref: FMA:67343
xref: MA:0000388
xref: MESH:D010063
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:0000548 ! animal cell
is_a: CL:0000675 {is_inferred="true"} ! female gamete
relationship: develops_from CL:0000023 ! oocyte
@@ -919,7 +910,6 @@ def: "A germline cell that contributes to the development of the oocyte by trans
synonym: "nurse cell" RELATED []
xref: BTO:0000953
xref: FBbt:00004878
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:0000412 ! polyploid cell
is_a: CL:4029002 ! germline-derived nurse cell
relationship: develops_from CL:0000722 ! cystoblast
@@ -936,7 +926,6 @@ relationship: develops_from CL:0000008 ! migratory cranial neural crest cell
[Term]
id: CL:0000028
name: CNS neuron (sensu Nematoda and Protostomia)
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:0000540 ! neuron
relationship: develops_from CL:0000338 ! neuroblast (sensu Nematoda and Protostomia)
relationship: part_of UBERON:0001017 ! central nervous system
@@ -945,7 +934,6 @@ relationship: part_of UBERON:0001017 ! central nervous system
id: CL:0000029
name: neural crest derived neuron
synonym: "neuron neural crest derived" EXACT []
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:0000540 {is_inferred="true"} ! neuron
intersection_of: CL:0000540 ! neuron
intersection_of: develops_from CL:0000333 ! migratory neural crest cell
@@ -954,7 +942,6 @@ relationship: develops_from CL:0002676 ! neural crest derived neuroblast
[Term]
id: CL:0000030
name: glioblast
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:0000055 ! non-terminally differentiated cell
is_a: CL:0000548 ! animal cell
relationship: develops_from CL:0000133 ! neurectodermal cell
@@ -976,7 +963,6 @@ id: CL:0000032
name: neuroplacodal cell
def: "A cell of a platelike structure, especially a thickened plate of ectoderm in the early embryo, from which a sense organ develops." [GOC:tfm, ISBN:0618947256]
synonym: "neural placode cell" EXACT []
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:0002321 ! embryonic cell (metazoa)
relationship: develops_from CL:0000114 ! surface ectodermal cell
@@ -1116,7 +1102,6 @@ synonym: "colony forming unit monocyte" RELATED []
synonym: "monocyte stem cell" RELATED []
xref: CALOHA:TS-1195
xref: FMA:83553
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0000763 ! myeloid cell
is_a: CL:0002194 {is_inferred="true"} ! monopoietic cell
is_a: PR:000050567 ! protein-containing material entity
@@ -1226,7 +1211,6 @@ synonym: "NSC" EXACT []
xref: BTO:0002881
xref: CALOHA:TS-2360
xref: FMA:86684
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:0002319 ! neural cell
relationship: develops_from CL:0000133 ! neurectodermal cell
@@ -1362,7 +1346,6 @@ xref: CALOHA:TS-0362
xref: FMA:63877
xref: NCIT:C12482
xref: VHOG:0001482
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:0002320 ! connective tissue cell
relationship: develops_from CL:0000134 ! mesenchymal stem cell
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
@@ -1374,7 +1357,6 @@ def: "Skeletogenic cell that is typically non-terminally differentiated, secrete
synonym: "chrondoplast" EXACT []
xref: BTO:0003607
xref: FMA:66783
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:0000055 ! non-terminally differentiated cell
is_a: CL:0002320 ! connective tissue cell
relationship: develops_from CL:0007009 ! prechondroblast
@@ -1597,7 +1579,6 @@ is_a: CL:0002371 ! somatic cell
[Term]
id: CL:0000079
name: stratified epithelial cell
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:0000066 ! epithelial cell
is_a: CL:0002371 ! somatic cell
relationship: develops_from CL:0000357 ! stratified epithelial stem cell
@@ -1643,7 +1624,6 @@ def: "An epithelial cell of the pancreas." [GOC:tfm]
synonym: "pancreas epithelial cell" EXACT []
synonym: "pancreatic epithelial cell" EXACT []
xref: BTO:0000028
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:0000066 {is_inferred="true"} ! epithelial cell
is_a: CL:0002371 ! somatic cell
intersection_of: CL:0000066 ! epithelial cell
@@ -1739,7 +1719,6 @@ synonym: "stellate cell of von Kupffer" EXACT []
synonym: "von Kupffer cell" EXACT []
xref: BTO:0000685
xref: FMA:14656
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0000864 {is_inferred="true"} ! tissue-resident macrophage
is_a: PR:000050567 ! protein-containing material entity
intersection_of: CL:0000864 ! tissue-resident macrophage
@@ -1767,7 +1746,6 @@ xref: BTO:0000968
xref: CALOHA:TS-0721
xref: FMA:66781
xref: MESH:D010010
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0000766 {is_inferred="true"} ! myeloid leukocyte
is_a: CL:0001035 {is_inferred="true"} ! bone cell
is_a: PR:000050567 ! protein-containing material entity
@@ -1810,7 +1788,6 @@ xref: BTO:0000539
xref: BTO:0001026
xref: CALOHA:TS-0422
xref: FMA:62854
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0000081 ! blood cell
is_a: CL:0000766 {is_inferred="true"} ! myeloid leukocyte
is_a: PR:000050567 ! protein-containing material entity
@@ -1837,7 +1814,6 @@ relationship: RO:0002104 PR:000001969 ! has plasma membrane part urokinase plasm
[Term]
id: CL:0000095
name: neuron associated cell
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:0002319 ! neural cell
relationship: develops_from CL:0000133 ! neurectodermal cell
@@ -1892,7 +1868,6 @@ synonym: "tissue basophil" RELATED [ISBN:068340007X]
xref: BTO:0000830
xref: CALOHA:TS-0603
xref: FMA:66784
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0000766 {is_inferred="true"} ! myeloid leukocyte
is_a: CL:0002274 ! histamine secreting cell
is_a: PR:000050567 ! protein-containing material entity
@@ -2023,7 +1998,6 @@ id: CL:0000107
name: autonomic neuron
def: "A neuron whose cell body is within an autonomic ganglion." [GOC:tfm]
xref: FMA:80121
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:2000032 ! peripheral nervous system neuron
intersection_of: CL:0000540 ! neuron
intersection_of: RO:0002100 UBERON:0002410 ! has soma location autonomic nervous system
@@ -2106,7 +2080,6 @@ is_a: CL:0000540 ! neuron
[Term]
id: CL:0000117
name: CNS neuron (sensu Vertebrata)
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:0000540 ! neuron
relationship: develops_from CL:0000031 ! neuroblast (sensu Vertebrata)
relationship: part_of UBERON:0001017 ! central nervous system
@@ -2202,6 +2175,7 @@ is_a: CL:0000095 ! neuron associated cell
id: CL:0000126
name: macroglial cell
def: "A neuroglial cell of ectodermal origin, i.e., the astrocytes and oligodendrocytes considered together." [GOC:tfm, ISBN:0721662544]
+synonym: "macroglia" RELATED PLURAL [doi:10.1152/physrev.2001.81.2.871]
synonym: "macrogliocyte" EXACT []
xref: BTO:0000771
xref: CALOHA:TS-2027
@@ -2249,13 +2223,12 @@ synonym: "brain macrophage" BROAD []
synonym: "brain-resident macrophage" EXACT []
synonym: "hortega cells" EXACT [http://www.copewithcytokines.de/]
synonym: "MF.microglia.CNS" RELATED []
-synonym: "microglia" EXACT []
+synonym: "microglia" RELATED PLURAL [doi:10.1038/s41598-020-66092-9]
synonym: "microgliocyte" EXACT [http://www.copewithcytokines.de/]
xref: BTO:0000078
xref: BTO:0000962
xref: FMA:54539
xref: FMA:54540
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0000125 ! glial cell
is_a: CL:0000878 ! central nervous system macrophage
is_a: PR:000050567 ! protein-containing material entity
@@ -2356,7 +2329,6 @@ synonym: "adipose cell" EXACT []
xref: BTO:0000443
xref: CALOHA:TS-0012
xref: FMA:63880
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:0000325 ! stuff accumulating cell
is_a: CL:0002320 ! connective tissue cell
relationship: develops_from CL:0000134 ! mesenchymal stem cell
@@ -2372,7 +2344,6 @@ xref: BTO:0002038
xref: CALOHA:TS-1167
xref: FMA:66779
xref: VSAO:0000124
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:0001035 ! bone cell
relationship: develops_from CL:0001040 ! non-terminally differentiated osteoblast
relationship: part_of UBERON:0002481 ! bone tissue
@@ -2394,7 +2365,6 @@ relationship: located_in UBERON:0002418 ! cartilage tissue
id: CL:0000140
name: odontocyte
def: "Skeletogenic cell that secretes dentine matrix, is derived from odontogenic papilla. Embedded in dentine tissue, and is the transformation of a non-terminally differentiated odontoblast cell." [GO_REF:0000034]
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:0002320 ! connective tissue cell
relationship: develops_from CL:0000060 ! odontoblast
relationship: develops_from CL:0000134 ! mesenchymal stem cell
@@ -2475,7 +2445,6 @@ xref: CALOHA:TS-0613
xref: FMA:70545
xref: MESH:D008544
xref: VHOG:0001679
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:0000147 {is_inferred="true"} ! pigment cell
is_a: CL:0002371 ! somatic cell
intersection_of: CL:0000147 ! pigment cell
@@ -2581,7 +2550,6 @@ subset: human_reference_atlas
synonym: "Clara cell" EXACT []
xref: BTO:0004811
xref: FMA:14119
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0000157 ! surfactant secreting cell
is_a: CL:0002202 ! epithelial cell of tracheobronchial tree
is_a: CL:0011026 ! progenitor cell
@@ -2831,7 +2799,6 @@ xref: CALOHA:TS-1150
xref: EMAPA:29655
xref: FMA:72297
xref: MESH:D007985
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:0000177 ! testosterone secreting cell
is_a: CL:0000548 ! animal cell
is_a: CL:4030031 ! interstitial cell
@@ -2872,7 +2839,6 @@ subset: human_reference_atlas
xref: BTO:0000575
xref: CALOHA:TS-0454
xref: FMA:14515
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:0000066 ! epithelial cell
is_a: CL:0000417 ! endopolyploid cell
is_a: CL:0002371 ! somatic cell
@@ -2924,7 +2890,6 @@ xref: CALOHA:TS-2032
xref: FBbt:00005074
xref: FMA:67328
xref: WBbt:0003675
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:0000183 ! contractile cell
is_a: CL:0000393 ! electrically responsive cell
is_a: CL:0002371 ! somatic cell
@@ -3532,7 +3497,7 @@ xref: EFO:0003711
xref: VHOG:0001484
xref: ZFA:0009150
is_a: CL:0000006 ! neuronal receptor cell
-is_a: CL:0000531 ! primary sensory neuron
+is_a: CL:0000531 ! primary sensory neuron (sensu Teleostei)
is_a: CL:4023168 ! somatosensory neuron
[Term]
@@ -4095,7 +4060,6 @@ is_a: CL:0000154 ! protein secreting cell
[Term]
id: CL:0000324
name: metanephric mesenchyme stem cell
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:0000134 ! mesenchymal stem cell
relationship: develops_from CL:0000222 ! mesodermal cell
@@ -4247,7 +4211,6 @@ id: CL:0000345
name: dental papilla cell
def: "A mesenchymal cell that is part of a small mass of condensed mesenchyme in the enamel organ; it differentiates into the dentin and dental pulp." [GOC:tfm, ISBN:0721662544]
comment: Merge with odontoblast?
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:0008019 ! mesenchymal cell
relationship: develops_from CL:0000008 ! migratory cranial neural crest cell
relationship: part_of UBERON:0001763 ! odontogenic papilla
@@ -4269,7 +4232,6 @@ id: CL:0000347
name: scleral cell
def: "A cell of the sclera of the eye." [GOC:add]
subset: eye_upper_slim
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:0000293 ! structural cell
is_a: CL:0000548 ! animal cell
intersection_of: CL:0000293 ! structural cell
@@ -4282,7 +4244,6 @@ id: CL:0000348
name: choroidal cell of the eye
def: "A structural cell that is part of optic choroid." [GOC:add]
subset: eye_upper_slim
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:0000293 ! structural cell
is_a: CL:0000548 ! animal cell
intersection_of: CL:0000293 ! structural cell
@@ -4588,7 +4549,6 @@ id: CL:0000387
name: hemocyte (sensu Arthropoda)
def: "A blood cell of the circulatory system of arthropods." [doi:10.1016/B978-012369493-5.50008-0]
xref: FBbt:00005063
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:0000390 ! blood cell (sensu Nematoda and Protostomia)
relationship: develops_from CL:0000385 ! prohemocyte (sensu Nematoda and Protostomia)
relationship: only_in_taxon NCBITaxon:6656 ! Arthropoda
@@ -4908,7 +4868,6 @@ id: CL:0000430
name: xanthophore cell
def: "A pigment cell derived from the neural crest. Contains cartenoid pigments in structures called pterinosomes or xanthosomes. This gives an appearance ranging from a golden yellow to orange and red." [SANBI:mhl]
synonym: "xanthophore" RELATED []
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:0000147 ! pigment cell
relationship: develops_from CL:0005002 ! xanthoblast
@@ -4917,7 +4876,6 @@ id: CL:0000431
name: iridophore
def: "A pigment cell derived from the neural crest. The cell contains flat light-reflecting platelets, probably of guanine, in stacks called reflecting platelets or iridisomes. The color-generating components produce a silver, gold, or iridescent color." [SANBI:mhl]
synonym: "guanophore" RELATED []
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:0000147 ! pigment cell
is_a: CL:0000548 ! animal cell
relationship: develops_from CL:0005001 ! iridoblast
@@ -5288,7 +5246,6 @@ id: CL:0000469
name: ganglion mother cell
def: "A neural progenitor cell that is the daughter of a neuroblast (sensu arthopoda). The progeny of ganglion mother cells develop into neurons, glia and (occasionally) epithelial cells." []
xref: FBbt:00005149
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:0011020 ! neural progenitor cell
relationship: develops_from CL:0000338 ! neuroblast (sensu Nematoda and Protostomia)
@@ -5345,7 +5302,6 @@ def: "A somatic epithelial cell of the insect egg chamber." []
synonym: "follicle cell" BROAD []
synonym: "ovarian follicle cell" BROAD []
xref: FBbt:00004904
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:0000500 ! follicular epithelial cell
is_a: CL:2000064 ! ovarian surface epithelial cell
relationship: develops_from CL:0000441 ! follicle stem cell (sensu Arthropoda)
@@ -5538,7 +5494,6 @@ subset: general_cell_types_upper_slim
subset: human_reference_atlas
xref: BTO:0002064
xref: FMA:83624
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:0002320 ! connective tissue cell
relationship: develops_from CL:0000134 ! mesenchymal stem cell
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
@@ -5711,7 +5666,6 @@ id: CL:0000517
name: macrophage derived foam cell
def: "A type of foam cell derived from a macrophage containing lipids in small vacuoles and typically seen in atherolosclerotic lesions, as well as other conditions." [GOC:add, PMID:20213546]
synonym: "lipophage" EXACT []
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:0000891 ! foam cell
relationship: develops_from CL:0000235 ! macrophage
@@ -5813,48 +5767,54 @@ is_a: CL:0000710 ! neurecto-epithelial cell
[Term]
id: CL:0000530
-name: primary neuron
+name: primary neuron (sensu Teleostei)
+def: "A neuron that develops during the early segmentation stages in teleosts, before the neural tube is formed." [doi:10.1242/dev.108.1.121, PMID:1842357]
is_a: CL:0000540 ! neuron
+relationship: only_in_taxon NCBITaxon:32443 {http://purl.obolibrary.org/obo/IAO_0000233="https://github.com/obophenotype/cell-ontology/pull/1950"} ! Teleostei
[Term]
id: CL:0000531
-name: primary sensory neuron
+name: primary sensory neuron (sensu Teleostei)
+def: "A primary neuron (sensu Teleostei) that has a sensory function." [PMID:1842357]
is_a: CL:0000101 ! sensory neuron
-is_a: CL:0000530 ! primary neuron
+is_a: CL:0000530 ! primary neuron (sensu Teleostei)
intersection_of: CL:0000101 ! sensory neuron
-intersection_of: CL:0000530 ! primary neuron
+intersection_of: CL:0000530 ! primary neuron (sensu Teleostei)
[Term]
id: CL:0000532
name: CAP motoneuron
-is_a: CL:0000533 ! primary motor neuron
+is_a: CL:0000533 ! primary motor neuron (sensu Teleostei)
[Term]
id: CL:0000533
-name: primary motor neuron
-xref: FMA:83619
+name: primary motor neuron (sensu Teleostei)
+def: "A primary neuron (sensu Teleostei) that has a motor function." [PMID:1842357]
is_a: CL:0000100 ! motor neuron
-is_a: CL:0000530 ! primary neuron
+is_a: CL:0000530 ! primary neuron (sensu Teleostei)
[Term]
id: CL:0000534
-name: primary interneuron
+name: primary interneuron (sensu Teleostei)
+def: "A primary neuron (sensu Teleostei) that is neither a sensory neuron or a motor neuron." [PMID:1842357]
is_a: CL:0000099 ! interneuron
-is_a: CL:0000530 ! primary neuron
+is_a: CL:0000530 ! primary neuron (sensu Teleostei)
[Term]
id: CL:0000535
-name: secondary neuron
+name: secondary neuron (sensu Teleostei)
+def: "A neuron of teleosts that develops later than a primary neuron, typically during the larval stages." [doi:10.1242/dev.108.1.121, PMID:1842357]
is_a: CL:0000540 ! neuron
+relationship: only_in_taxon NCBITaxon:32443 {http://purl.obolibrary.org/obo/IAO_0000233="https://github.com/obophenotype/cell-ontology/pull/1950"} ! Teleostei
[Term]
id: CL:0000536
-name: secondary motor neuron
-xref: FMA:83620
+name: secondary motor neuron (sensu Teleostei)
+def: "A secondary neuron (sensu Teleostei) that has a motor function." [PMID:1842357]
is_a: CL:0000100 ! motor neuron
-is_a: CL:0000535 ! secondary neuron
+is_a: CL:0000535 ! secondary neuron (sensu Teleostei)
intersection_of: CL:0000100 ! motor neuron
-intersection_of: CL:0000535 ! secondary neuron
+intersection_of: CL:0000535 ! secondary neuron (sensu Teleostei)
[Term]
id: CL:0000537
@@ -6012,7 +5972,6 @@ subset: blood_and_immune_upper_slim
synonym: "pronormoblast" RELATED []
synonym: "rubriblast" EXACT [ISBN:0721601464]
xref: FMA:83518
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0000764 {is_inferred="true"} ! erythroid lineage cell
is_a: CL:0002242 ! nucleate cell
is_a: PR:000050567 ! protein-containing material entity
@@ -6070,7 +6029,6 @@ synonym: "early erythroblast" EXACT [ISBN:0721601464]
synonym: "early normoblast" EXACT [ISBN:0721601464]
synonym: "prorubricyte" EXACT [ISBN:0721601464]
xref: FMA:83505
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0000765 {is_inferred="true"} ! erythroblast
is_a: PR:000050567 ! protein-containing material entity
intersection_of: CL:0000765 ! erythroblast
@@ -6092,7 +6050,6 @@ synonym: "polychromatic normoblast" EXACT [ISBN:0721601464]
synonym: "polychromatophilic normoblast" EXACT [ISBN:0721601464]
synonym: "rubricyte" EXACT [ISBN:0721601464]
xref: FMA:83506
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0000765 {is_inferred="true"} ! erythroblast
is_a: PR:000050567 ! protein-containing material entity
intersection_of: CL:0000765 ! erythroblast
@@ -6206,7 +6163,6 @@ xref: BTO:0000843
xref: CALOHA:TS-0611
xref: FMA:83555
is_a: CL:0000763 {is_inferred="true"} ! myeloid cell
-is_a: CL:4033018 {gci_relation="part_of", gci_filler="UBERON:0000114"} ! lung megakaryocyte
disjoint_from: CL:0000764 ! erythroid lineage cell
relationship: bearer_of PATO:0001393 ! euploid
relationship: develops_from CL:0000553 ! megakaryocyte progenitor cell
@@ -6225,7 +6181,6 @@ synonym: "GMP" EXACT [ISBN:0721601464, PMCID:PMC2213186, PMCID:PMC548021]
synonym: "granulocyte-macrophage progenitor" EXACT [ISBN:0721601464, PMCID:PMC2213186, PMCID:PMC548021]
synonym: "granulocyte/monocyte precursor" EXACT []
synonym: "granulocyte/monocyte progenitor" EXACT []
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0000763 ! myeloid cell
is_a: CL:0001012 ! CD7-negative lymphoid progenitor OR granulocyte monocyte progenitor
is_a: CL:0011026 ! progenitor cell
@@ -6257,7 +6212,6 @@ subset: blood_and_immune_upper_slim
xref: BTO:0001173
xref: CALOHA:TS-0864
xref: MESH:D012156
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0000764 {is_inferred="true"} ! erythroid lineage cell
is_a: PR:000050567 ! protein-containing material entity
intersection_of: CL:0000764 ! erythroid lineage cell
@@ -6297,7 +6251,6 @@ comment: Morphology: Mononuclear cell, diameter 14-18 _M, fine azurophilic granu
subset: human_reference_atlas
xref: BTO:0004657
xref: FMA:83551
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0000763 ! myeloid cell
is_a: CL:0002194 {is_inferred="true"} ! monopoietic cell
is_a: PR:000050567 ! protein-containing material entity
@@ -6349,10 +6302,11 @@ name: amacrine cell
def: "Interneuron of the vertebrate retina. They integrate, modulate, and interpose a temporal domain in the visual message presented to the retinal ganglion cells, with which they synapse in the inner plexiform layer. They lack large axons." [GOC:tfm, MESH:D025042, WikipediaVersioned:Amacrine_cell&oldid=1023572246]
subset: eye_upper_slim
subset: human_reference_atlas
+synonym: "AC" RELATED abbreviation [doi:10.1038/s41598-020-66092-9]
+synonym: "ACs" RELATED PLURAL [doi:10.1038/s41598-020-66092-9]
synonym: "amacrine neuron" EXACT []
xref: BTO:0004044
xref: FMA:67766
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:0000099 ! interneuron
is_a: CL:0009004 ! retinal cell
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
@@ -6421,7 +6375,6 @@ comment: These cells are reportedly CD31-positive, CD34-positive, CD144-positive
subset: human_reference_atlas
synonym: "angioblast" EXACT []
synonym: "chondroplast" EXACT []
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0000134 {is_inferred="true"} ! mesenchymal stem cell
is_a: CL:0011026 ! progenitor cell
is_a: PR:000050567 ! protein-containing material entity
@@ -6470,7 +6423,6 @@ synonym: "parafollicular cell of thyroid gland" EXACT [FMA:68653]
synonym: "thyroid parafollicular cell" EXACT [FMA:68653]
xref: FMA:68653
xref: SCTID:176770005
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0000443 {is_inferred="true"} ! calcitonin secreting cell
is_a: CL:0000458 ! serotonin secreting cell
is_a: CL:0000710 {is_inferred="true"} ! neurecto-epithelial cell
@@ -6489,7 +6441,6 @@ relationship: RO:0002104 PR:000001024 ! has plasma membrane part neural cell adh
id: CL:0000571
name: leucophore
def: "A pigment cell derived from the neural crest. Contains uric acid or other purine crystals deposited in stacks called leucosomes. The crystals reflect light and this gives a white appearance under white light." [SANBI:mhl]
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:0000147 ! pigment cell
is_a: CL:0000548 ! animal cell
relationship: develops_from CL:0005003 ! leucoblast
@@ -6499,6 +6450,7 @@ id: CL:0000573
name: retinal cone cell
def: "One of the two photoreceptor cell types in the vertebrate retina. In cones the photopigment is in invaginations of the cell membrane of the outer segment. Cones are less sensitive to light than rods, but they provide vision with higher spatial and temporal acuity, and the combination of signals from cones with different pigments allows color vision." [MESH:D017949]
subset: human_reference_atlas
+synonym: "cone" RELATED [doi:10.1038/s41598-020-66092-9]
xref: BTO:0001036
xref: CALOHA:TS-0866
xref: FMA:67748
@@ -6510,7 +6462,6 @@ relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
id: CL:0000574
name: erythrophore
def: "A pigment cell derived from the neural crest. Contains pteridine and/or carotenoid pigments in structures called pterinosomes or erythrosomes. This gives an orange to red appearance." [SANBI:mhl]
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:0000147 ! pigment cell
is_a: CL:0000548 ! animal cell
relationship: develops_from CL:0005004 ! pigment erythroblast
@@ -6639,7 +6590,6 @@ def: "A macrophage resident in the peritoneum under non-inflammatory conditions.
comment: Markers: Mouse: F4/80-high, CD11b-high, CD68+, SIGNR1+, Dectin-1+.
xref: BTO:0001034
xref: FMA:83025
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0000864 {is_inferred="true"} ! tissue-resident macrophage
is_a: PR:000050567 ! protein-containing material entity
intersection_of: CL:0000864 ! tissue-resident macrophage
@@ -6720,7 +6670,6 @@ synonym: "MF.Lu" RELATED []
xref: BTO:0000802
xref: CALOHA:TS-0030
xref: FMA:83023
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0000864 {is_inferred="true"} ! tissue-resident macrophage
is_a: CL:1001603 ! lung macrophage
is_a: PR:000050567 ! protein-containing material entity
@@ -6935,6 +6884,7 @@ id: CL:0000604
name: retinal rod cell
def: "One of the two photoreceptor cell types of the vertebrate retina. In rods the photopigment is in stacks of membranous disks separate from the outer cell membrane. Rods are more sensitive to light than cones, but rod mediated vision has less spatial and temporal resolution than cone vision." [MESH:D017948]
subset: human_reference_atlas
+synonym: "rod" RELATED [doi:10.1038/s41598-020-66092-9]
xref: BTO:0001024
xref: CALOHA:TS-0870
xref: FMA:67747
@@ -6994,7 +6944,6 @@ synonym: "CFU-Eo" RELATED []
synonym: "colony forming unit eosinophil" RELATED []
synonym: "EoP" EXACT [PMCID:PMC2212039, PMCID:PMC2626675]
synonym: "eosinophil stem cell" RELATED []
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0000763 ! myeloid cell
is_a: CL:0002191 {is_inferred="true"} ! granulocytopoietic cell
is_a: PR:000050567 ! protein-containing material entity
@@ -7078,7 +7027,6 @@ synonym: "BaP" EXACT []
synonym: "basophilic stem cell" RELATED []
synonym: "CFU-Bas" RELATED []
synonym: "colony forming unit basophil" RELATED []
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0000763 ! myeloid cell
is_a: CL:0002191 {is_inferred="true"} ! granulocytopoietic cell
is_a: PR:000050567 ! protein-containing material entity
@@ -7339,7 +7287,6 @@ synonym: "vitamin A-storing cells" RELATED [PMID:12808230]
xref: BTO:0002741
xref: CALOHA:TS-0452
xref: FMA:67763
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0000057 ! fibroblast
is_a: CL:0000327 ! extracellular matrix secreting cell
is_a: PR:000050567 ! protein-containing material entity
@@ -7384,6 +7331,7 @@ name: Mueller cell
def: "Astrocyte-like radial glial cell that extends vertically throughout the retina, with the nucleus are usually in the middle of the inner nuclear layer." [GOC:NV, PMID:21911394]
subset: eye_upper_slim
subset: human_reference_atlas
+synonym: "Muller cell" EXACT MISSPELLING [doi:10.21769/BioProtoc.4179]
synonym: "Muller glia" EXACT []
synonym: "Müller cell" EXACT []
xref: BTO:0003064
@@ -7438,9 +7386,17 @@ is_a: CL:0000163 ! endocrine cell
[Term]
id: CL:0000642
name: folliculostellate cell
-def: "A supportive cell of the vertebrate pituitary that provides macromolecular transport and secretes hormones." [JB:jb]
-is_a: CL:0000163 ! endocrine cell
+def: "An agranular supporting cell of the anterior pituitary (adenohypophysis) that is characterized by a star-like morphology and ability to form follicles. Folliculostellate cells communicate with each other and with endocrine cells via gap junctions." [doi:10.23937/2572-407X.1510006, JB:jb, PMID:10495875, PMID:15961560]
+comment: Folliculostellate cells are a heterogeneous group of cells rather than a single cell type, with different morphology and gene expression profiles. Due to this heterogeneity, it is unclear if different properties that have been attributed to folliculostellate cells (pluripotent, proliferative, phagocytic) are common in all folliculostellate cells or limited to particular subsets. {xref="doi:10.23937/2572-407X.1510006", xref="PMID:34734454", xref="PMID:31620083", xref="PMID:18287078"}
+synonym: "folliculo-stellate cell" EXACT [doi:10.23937/2572-407X.1510006]
+synonym: "FS cell" RELATED abbreviation [PMID:34734454]
+synonym: "FSC" RELATED abbreviation [doi:10.23937/2572-407X.1510006]
+synonym: "pituitary folliculostellate cell" EXACT [PMID:34734454]
+synonym: "Sox2-positive stem cell" RELATED [PMID:34734454]
+is_a: CL:0000512 ! paracrine cell
is_a: CL:0000630 ! supporting cell
+is_a: CL:2000004 ! pituitary gland cell
+relationship: part_of UBERON:0002196 ! adenohypophysis
[Term]
id: CL:0000644
@@ -7538,7 +7494,6 @@ xref: BTO:0000853
xref: CALOHA:TS-0617
xref: FMA:70972
xref: MESH:D050527
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:0000669 ! pericyte
relationship: develops_from CL:0000134 ! mesenchymal stem cell
@@ -7591,7 +7546,6 @@ subset: human_reference_atlas
synonym: "primary oogonium" RELATED []
xref: BTO:0000512
xref: FMA:18645
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:0000023 {is_inferred="true"} ! oocyte
intersection_of: CL:0000023 ! oocyte
intersection_of: CL:4030044 GO:0051321 ! has_not_completed meiotic cell cycle
@@ -7606,7 +7560,6 @@ def: "A secondary oocyte is an oocyte that has not completed meiosis II." [GOC:t
synonym: "primary oogonium" RELATED []
xref: BTO:0003094
xref: FMA:18646
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:0000023 {is_inferred="true"} ! oocyte
intersection_of: CL:0000023 ! oocyte
intersection_of: CL:4030044 GO:0007147 ! has_not_completed female meiosis II
@@ -7831,7 +7784,6 @@ relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
id: CL:0000680
name: muscle precursor cell
def: "A non-terminally differentiated cell that is capable of developing into a muscle cell." [GOC:add]
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:0000055 ! non-terminally differentiated cell
is_a: CL:0002371 ! somatic cell
intersection_of: CL:0011115 ! precursor cell
@@ -8333,7 +8285,6 @@ xref: CALOHA:TS-0549
xref: FMA:62852
xref: MESH:D007962
xref: NCIT:C12529
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:0000219 ! motile cell
is_a: CL:0000988 {is_inferred="true"} ! hematopoietic cell
is_a: CL:0002242 ! nucleate cell
@@ -8354,7 +8305,8 @@ subset: eye_upper_slim
subset: human_reference_atlas
synonym: "gangliocyte" EXACT []
synonym: "ganglion cell of retina" EXACT []
-synonym: "RGC" EXACT []
+synonym: "RGC" RELATED abbreviation [doi:10.1038/s41598-020-66092-9]
+synonym: "RGCs" RELATED PLURAL [doi:10.1038/s41598-020-66092-9]
xref: BTO:0001800
xref: FMA:67765
xref: MESH:D012165
@@ -8394,9 +8346,10 @@ name: retina horizontal cell
def: "A neuron that laterally connects other neurons in the inner nuclear layer of the retina." [ISBN:0195088433]
subset: eye_upper_slim
subset: human_reference_atlas
+synonym: "HC" RELATED abbreviation [doi:10.1038/s41598-020-66092-9]
+synonym: "HCs" RELATED PLURAL [doi:10.1038/s41598-020-66092-9]
synonym: "horizontal cell" EXACT []
xref: BTO:0004120
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:0000099 ! interneuron
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: RO:0002100 UBERON:0003902 ! has soma location retinal neural layer
@@ -8435,7 +8388,6 @@ id: CL:0000747
name: cyanophore
def: "A pigment cell derived from the neural crest. Contains blue pigment of unknown chemical composition in fibrous organelles termed cyanosomes. This gives a blue appearance." [SANBI:mhl]
synonym: "blue chromatophore" RELATED []
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:0000147 ! pigment cell
is_a: CL:0000548 ! animal cell
relationship: develops_from CL:0005005 ! cyanoblast
@@ -8446,15 +8398,17 @@ name: retinal bipolar neuron
def: "A bipolar neuron found in the retina and having connections with photoreceptors cells and neurons in the inner plexiform layer." [PMID:14689473]
subset: eye_upper_slim
subset: human_reference_atlas
-is_a: CARO:0000000 ! anatomical entity
+synonym: "BC" RELATED abbreviation [doi:10.1038/s41598-020-66092-9]
+synonym: "BCs" RELATED PLURAL [doi:10.1038/s41598-020-66092-9]
+synonym: "BPs" RELATED PLURAL [GSE137537]
is_a: CL:0000103 ! bipolar neuron
is_a: CL:0000679 ! glutamatergic neuron
is_a: CL:0008028 ! visual system neuron
is_a: CL:0009004 ! retinal cell
intersection_of: CL:0000103 ! bipolar neuron
-intersection_of: RO:0002100 UBERON:0000966 ! has soma location retina
+intersection_of: RO:0002100 UBERON:0001791 ! has soma location inner nuclear layer of retina
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-relationship: RO:0002100 UBERON:0000966 ! has soma location retina
+relationship: RO:0002100 UBERON:0001791 ! has soma location inner nuclear layer of retina
[Term]
id: CL:0000749
@@ -8463,7 +8417,6 @@ def: "A bipolar neuron found in the retina and having connections with photorece
subset: human_reference_atlas
is_a: CL:0000748 ! retinal bipolar neuron
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-relationship: RO:0002100 UBERON:0001791 ! has soma location inner nuclear layer of retina
[Term]
id: CL:0000750
@@ -8599,7 +8552,6 @@ def: "A cell of the monocyte, granulocyte, mast cell, megakaryocyte, or erythroi
xref: BTO:0001441
xref: CALOHA:TS-0647
xref: MESH:D022423
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:0000988 {is_inferred="true"} ! hematopoietic cell
intersection_of: CL:0000988 ! hematopoietic cell
intersection_of: develops_from CL:0000049 ! common myeloid progenitor
@@ -9026,7 +8978,6 @@ synonym: "plasmocyte" EXACT []
xref: BTO:0000392
xref: FMA:70574
xref: MESH:D010950
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0000946 {is_inferred="true"} ! antibody secreting cell
intersection_of: CL:0000946 ! antibody secreting cell
intersection_of: CL:4030046 GO:0019814 ! lacks_plasma_membrane_part immunoglobulin complex
@@ -9096,7 +9047,6 @@ subset: blood_and_immune_upper_slim
synonym: "alpha-beta T lymphocyte" EXACT []
synonym: "alpha-beta T-cell" EXACT []
synonym: "alpha-beta T-lymphocyte" EXACT []
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0000084 {is_inferred="true"} ! T cell
intersection_of: CL:0000084 ! T cell
intersection_of: RO:0002104 GO:0042105 ! has plasma membrane part alpha-beta T cell receptor complex
@@ -9267,7 +9217,6 @@ synonym: "gamma-delta T-cell" EXACT []
synonym: "gamma-delta T-lymphocyte" EXACT []
synonym: "gammadelta T cell" EXACT []
synonym: "gd T cell" RELATED []
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0000084 {is_inferred="true"} ! T cell
intersection_of: CL:0000084 ! T cell
intersection_of: RO:0002104 GO:0042106 ! has plasma membrane part gamma-delta T cell receptor complex
@@ -9360,7 +9309,6 @@ synonym: "immature single positive T lymphocyte" EXACT []
synonym: "immature single positive T-lymphocyte" EXACT []
synonym: "ISP" EXACT []
synonym: "T.ISP.th" EXACT []
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0000893 {is_inferred="true"} ! thymocyte
intersection_of: CL:0000893 ! thymocyte
intersection_of: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule
@@ -9391,7 +9339,6 @@ synonym: "double negative 2" EXACT []
synonym: "preT.DN2.Th" EXACT []
synonym: "TN2 cell" EXACT []
synonym: "TN2 thymocyte" EXACT []
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0002489 ! double negative thymocyte
intersection_of: CL:0000893 ! thymocyte
intersection_of: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule
@@ -9417,7 +9364,6 @@ synonym: "early cortical thymocyte" BROAD []
synonym: "preT.DN3.Th" EXACT []
synonym: "TN3 cell" EXACT []
synonym: "TN3 thymocyte" EXACT []
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0002489 ! double negative thymocyte
intersection_of: CL:0000893 ! thymocyte
intersection_of: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule
@@ -9443,7 +9389,6 @@ synonym: "DN4 immature T-cell" EXACT []
synonym: "double negative 4" EXACT []
synonym: "early cortical thymocyte" BROAD []
synonym: "T.DN4.th" EXACT []
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0002489 ! double negative thymocyte
intersection_of: CL:0000893 ! thymocyte
intersection_of: CL:4030046 PR:000001004 ! lacks_plasma_membrane_part CD4 molecule
@@ -9771,7 +9716,6 @@ synonym: "NKP" EXACT [PMID:12457618, PMID:15032583, PMID:15766674]
synonym: "null cell" RELATED [PMID:11532393]
synonym: "preNK cell" RELATED [PMID:11532393]
synonym: "pro-natural killer cell" EXACT []
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0000838 {is_inferred="true"} ! lymphoid lineage restricted progenitor cell
is_a: PR:000050567 ! protein-containing material entity
intersection_of: CL:0000838 ! lymphoid lineage restricted progenitor cell
@@ -9876,7 +9820,6 @@ synonym: "CFU-Mast" RELATED []
synonym: "CFU-MC" RELATED []
synonym: "colony forming unit mast cell" RELATED []
synonym: "MCP" EXACT []
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0000763 ! myeloid cell
is_a: CL:0000839 {is_inferred="true"} ! myeloid lineage restricted progenitor cell
is_a: PR:000050567 ! protein-containing material entity
@@ -9991,7 +9934,6 @@ def: "A precursor in the granulocytic series, being a cell intermediate in devel
subset: human_reference_atlas
xref: CALOHA:TS-0825
xref: FMA:83530
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0000763 ! myeloid cell
is_a: CL:0002191 ! granulocytopoietic cell
is_a: PR:000050567 ! protein-containing material entity
@@ -10028,7 +9970,6 @@ synonym: "hemopoietic progenitor cell" EXACT []
synonym: "MPP" EXACT []
xref: BTO:0000725
xref: CALOHA:TS-0448
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0008001 ! hematopoietic precursor cell
is_a: PR:000050567 ! protein-containing material entity
intersection_of: CL:0000988 ! hematopoietic cell
@@ -10322,7 +10263,6 @@ intersection_of: part_of UBERON:0001997 ! olfactory epithelium
id: CL:0000854
name: interneuromast cell
def: "Interneuromast cell is a neuroectodermal cell deposited by the migrating lateral line primordium between the neuromasts. Interneuromast cells proliferate and migrate to form additional neuromasts." [SANBI:mhl]
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:0000133 ! neurectodermal cell
relationship: develops_from CL:0000032 ! neuroplacodal cell
@@ -10338,7 +10278,6 @@ is_a: CL:0000199 ! mechanoreceptor cell
id: CL:0000856
name: neuromast hair cell
def: "Neuromast hair cell is a hair cell that acts as a sensory receptor of the neuromast; it is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface." [SANBI:mhl]
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:0000006 ! neuronal receptor cell
is_a: CL:0000855 ! sensory hair cell
intersection_of: CL:0000855 ! sensory hair cell
@@ -10370,7 +10309,6 @@ def: "A monocyte that responds rapidly to microbial stimuli by secreting cytokin
comment: Markers: CCR2+CXCCR1 (human, mouse, rat).
subset: human_reference_atlas
synonym: "inflammatory monocyte" EXACT []
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0000234 ! phagocyte
is_a: CL:0000576 {is_inferred="true"} ! monocyte
is_a: PR:000050567 ! protein-containing material entity
@@ -10399,7 +10337,6 @@ synonym: "free macrophage" EXACT []
synonym: "wandering histiocyte" EXACT []
xref: FMA:84643
xref: FMA:84645
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0000235 {is_inferred="true"} ! macrophage
is_a: PR:000050567 ! protein-containing material entity
intersection_of: CL:0000235 ! macrophage
@@ -10496,7 +10433,6 @@ name: lymph node macrophage
def: "A secondary lymphoid organ macrophage found in a lymph node. This cell is CD169-high." [GO_REF:0000031, GOC:ana, GOC:tfm, PMID:11971865]
comment: Marker was observed on rat cells.
synonym: "MF.LN" EXACT []
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0000867 {is_inferred="true"} ! secondary lymphoid organ macrophage
is_a: PR:000050567 ! protein-containing material entity
intersection_of: CL:0000867 ! secondary lymphoid organ macrophage
@@ -10548,7 +10484,6 @@ name: splenic marginal zone macrophage
def: "A splenic macrophage found in the marginal zone of the spleen, involved in recognition and clearance of particulate material from the splenic circulation. Markers include F4/80-negative, MARCO-positive, SR-A-positive, SIGN-R1-positive, and Dectin2-positive." [GO_REF:0000031, GOC:ana, PMID:16861066]
comment: Markers: Mouse: F4/80-, MARCO+, SR-A+, SIGN-R1+, Dectin2+.
subset: human_reference_atlas
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0000871 {is_inferred="true"} ! splenic macrophage
is_a: PR:000050567 ! protein-containing material entity
intersection_of: CL:0000871 ! splenic macrophage
@@ -10571,7 +10506,6 @@ id: CL:0000873
name: splenic metallophillic macrophage
def: "A splenic macrophage found in the areas surrounding the white pulp of the spleen, adjacent to the marginal sinus. Markers include F4/80-negative, Dectin2-low, sialoadhesin-positive." [GO_REF:0000031, GOC:ana, PMID:20018690]
comment: Markers: Mouse: F4/80-, Dectin2-low, sialoadhesin+.
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0000871 {is_inferred="true"} ! splenic macrophage
is_a: PR:000050567 ! protein-containing material entity
intersection_of: CL:0000871 ! splenic macrophage
@@ -10592,7 +10526,6 @@ name: splenic red pulp macrophage
def: "A splenic macrophage found in the red-pulp of the spleen, and involved in immune responses to blood-borne pathogens and in the clearance of senescent erythrocytes. Markers include F4/80-positive, CD68-positive, MR-positive, Dectin2-positive, macrosialin-positive, and sialoadhesin-low." [GO_REF:0000031, GOC:ana, PMID:19644016]
comment: Markers: Mouse: F4/80+, CD68+, MR+, Dectin2+, macrosialin+, sialoadhesin-low; role or process: immune, clearance of senescent erythrocytes.
subset: human_reference_atlas
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0000871 {is_inferred="true"} ! splenic macrophage
is_a: PR:000050567 ! protein-containing material entity
intersection_of: CL:0000871 ! splenic macrophage
@@ -10625,7 +10558,6 @@ comment: Markers: CCR2-CX3CCR1+ (human, mouse, rat); human: CD16+, CCR5+, CD32/F
subset: human_reference_atlas
synonym: "patrolling monocyte" EXACT []
synonym: "resident monocyte" EXACT []
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0000576 {is_inferred="true"} ! monocyte
is_a: PR:000050567 ! protein-containing material entity
intersection_of: CL:0000576 ! monocyte
@@ -10652,7 +10584,6 @@ name: splenic white pulp macrophage
def: "A splenic macrophage found in the white pulp of the spleen. Markers include F4/80-negative, CD68-positive, and macrosialin-positive." [GO_REF:0000031, GOC:ana, PMID:11207597]
comment: Markers: Mouse: F4/80-, CD68+, macrosialin+.
subset: human_reference_atlas
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0000871 {is_inferred="true"} ! splenic macrophage
is_a: PR:000050567 ! protein-containing material entity
intersection_of: CL:0000871 ! splenic macrophage
@@ -10717,7 +10648,6 @@ id: CL:0000881
name: perivascular macrophage
def: "A central nervous system macrophage found in small blood vessels in the brain. Markers include CD14+CD16+CD163+." [GO_REF:0000031, GOC:tfm, PMID:16507898]
comment: Markers: Human/monkey, mice: CD163. Human: CD14+CD16+CD163+.
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0000878 {is_inferred="true"} ! central nervous system macrophage
is_a: PR:000050567 ! protein-containing material entity
intersection_of: CL:0000878 ! central nervous system macrophage
@@ -10819,7 +10749,6 @@ name: myeloid suppressor cell
def: "An immature myeloid leukocyte of heterogeneous phenotype found particularly in cancer and sepsis patients that is capable of suppressing activity of T cells in ex vivo assays. This cell type is CD45-positive, CD11b-positive." [GO_REF:0000031, GOC:add, GOC:ana, PMID:16168663, PMID:17016554, PMID:17016559]
comment: Markers: Mouse: CD11b+GR1+CD31+; Human: CD34+ CD33+CD15-CD13+. (According to some reports in humans these cells are iNOS+ARG1+IL13+IFNg+); location: In cancerous tissue; in the blood and lymphoid organs in sepsis.
subset: blood_and_immune_upper_slim
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0000766 {is_inferred="true"} ! myeloid leukocyte
is_a: PR:000050567 ! protein-containing material entity
intersection_of: CL:0000766 ! myeloid leukocyte
@@ -10858,7 +10787,6 @@ is_a: CL:0000003 ! native cell
id: CL:0000892
name: smooth muscle cell derived foam cell
def: "A type of foam cell derived from a smooth muscle cell containing lipids in small vacuoles and typically seen in atherolosclerotic lesions, as well as other conditions." [GOC:add, PMID:30664015]
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:0000891 ! foam cell
relationship: develops_from CL:0000192 ! smooth muscle cell
@@ -10893,7 +10821,6 @@ synonym: "DN1 thymic progenitor T cell" EXACT []
synonym: "DN1 thymocyte" EXACT []
synonym: "double negative 1" EXACT []
synonym: "preT.DN1.Th" EXACT []
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0000827 {is_inferred="true"} ! pro-T cell
is_a: PR:000050567 ! protein-containing material entity
intersection_of: CL:0000827 ! pro-T cell
@@ -11740,7 +11667,6 @@ name: pre-natural killer cell
def: "Cell committed to natural killer cell lineage that has the phenotype CD122-positive, CD34-positive, and CD117-positive. This cell type lacks expression of natural killer receptor proteins." [GO_REF:0000031, GOC:add, GOC:dsd, GOC:pam, GOC:tfm, PMID:16551251, PMID:17100874]
comment: These cells are also reportedly CD7-low, CD10-negative, CD45RA-positive, alpha-4-beta-7 integrin-high.
synonym: "pre-NK cell" EXACT []
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0000623 ! natural killer cell
intersection_of: CL:0000623 ! natural killer cell
intersection_of: RO:0002104 PR:000001003 ! has plasma membrane part CD34 molecule
@@ -11760,7 +11686,6 @@ synonym: "CD16-CD56bright NK cell" EXACT [PMID:22343568]
synonym: "CD16-negative, CD56-bright NK cell" EXACT []
synonym: "CD56-bright cytokine secreting natural killer cell" EXACT []
synonym: "CD56-bright cytokine secreting NK cell" EXACT []
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0000824 ! mature natural killer cell
intersection_of: CL:0000824 ! mature natural killer cell
intersection_of: capable_of GO:0032609 ! type II interferon production
@@ -11789,7 +11714,6 @@ synonym: "CD16-positive, CD56-positive natural killer cell" EXACT []
synonym: "CD16-positive, CD56-positive NK cell" EXACT []
synonym: "cytotoxic CD56-dim natural killer cell" EXACT []
synonym: "cytotoxic CD56-dim NK cell" EXACT []
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0000824 ! mature natural killer cell
intersection_of: CL:0000824 ! mature natural killer cell
intersection_of: capable_of GO:0001816 ! cytokine production
@@ -11844,7 +11768,6 @@ id: CL:0000942
name: thymic plasmacytoid dendritic cell
def: "A plasmacytoid dendritic cell developing in the thymus with phenotype CD11c-negative or low, CD45RA-positive, CD11b-negative, and CD123-positive." [GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm, PMID:19941119]
subset: human_reference_atlas
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0000784 {is_inferred="true"} ! plasmacytoid dendritic cell
intersection_of: CL:0000784 ! plasmacytoid dendritic cell
intersection_of: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M
@@ -12582,7 +12505,6 @@ id: CL:0000989
name: CD11c-low plasmacytoid dendritic cell
def: "CD11c-low plasmacytoid dendritic cell is a leukocyte that is CD11c-low, CD45R-positive, GR1-positive and CD11b-negative." [GO_REF:0000031, GOC:amm, GOC:dsd, PMID:15771572, PMID:17850486]
comment: Originally described in the dendritic cell ontology (DC_CL:0000001)(PMID:19243617). These cells are CD281-positive (TLR1), CD282-positive (TLR2), CD285-positive (TLR5), CD286-positive (TLR6), and CD288-positive (TLR8).
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0000784 {is_inferred="true"} ! plasmacytoid dendritic cell
intersection_of: CL:0000784 ! plasmacytoid dendritic cell
intersection_of: CL:4030046 PR:000001012 ! lacks_plasma_membrane_part integrin alpha-M
@@ -12608,7 +12530,6 @@ synonym: "interdigitating cell" BROAD []
synonym: "type 1 DC" EXACT []
synonym: "veiled cell" BROAD []
xref: FMA:84191
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0000451 {is_inferred="true"} ! dendritic cell
intersection_of: CL:0000451 ! dendritic cell
intersection_of: RO:0015015 PR:000001013 ! has high plasma membrane amount integrin alpha-X
@@ -12621,7 +12542,6 @@ name: CD11c-negative plasmacytoid dendritic cell
def: "CD11c-negative plasmacytoid dendritic cell is a leukocyte is CD11c-negative, CD45RA-positive, CD85g-positive(ILT7), CD123-positive, CD303-positive." [GO_REF:0000031, GOC:amm, PMID:15771572, PMID:17850486]
comment: Originally described in the dendritic cell ontology (DC_CL:0000004)(PMID:19243617). These cells are CD281-positive (TLR1), CD286-positive (TLR6), and CD290-positive (TLR10).
synonym: "CD303-positive dendritic cell" EXACT []
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0000784 {is_inferred="true"} ! plasmacytoid dendritic cell
intersection_of: CL:0000784 ! plasmacytoid dendritic cell
intersection_of: capable_of GO:0001816 ! cytokine production
@@ -12896,7 +12816,6 @@ def: "A hematopoietic stem cell that has plasma membrane part Kit-positive, SCA-
comment: Cell markers are associated with mouse hematopoietic stem cell. Originally described in the dendritic cell ontology (DC_CL:0000043)(PMID:19243617).
synonym: "LSK stem cell" EXACT []
synonym: "Sca1-positive hematopoietic stem cell" EXACT []
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0000037 {is_inferred="true"} ! hematopoietic stem cell
is_a: PR:000050567 ! protein-containing material entity
intersection_of: CL:0000037 ! hematopoietic stem cell
@@ -13074,7 +12993,6 @@ comment: These markers are associated with human common lymphoid progenitors. Or
synonym: "CD10-positive common lymphocyte precursor" EXACT []
synonym: "CD10-positive common lymphocyte progenitor" EXACT []
synonym: "CD10-positive common lymphoid precursor" EXACT []
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0000051 {is_inferred="true"} ! common lymphoid progenitor
is_a: CL:0000995 ! CD34-positive, CD38-positive common myeloid progenitor OR CD34-positive, CD38-positive common lymphoid progenitor
is_a: PR:000050567 ! protein-containing material entity
@@ -13095,7 +13013,6 @@ id: CL:0001022
name: CD115-positive monocyte
def: "CD115-positive monocyte is a monocyte that is CD115-positive and CD11b-positive." [GO_REF:0000031, GOC:add, GOC:amm, PMID:17952047]
comment: These markers are associated with human cells. Originally described in the dendritic cell ontology (DC_CL:0000033)(PMID:19243617).
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0000576 {is_inferred="true"} ! monocyte
is_a: CL:0000839 ! myeloid lineage restricted progenitor cell
is_a: CL:0001019 ! CD115-positive monocyte OR common dendritic progenitor
@@ -13137,7 +13054,6 @@ comment: Cell markers are associated with human hematopoietic stem cells. Origin
synonym: "CD133-positive hematopoietic stem cell" EXACT [PMID:16140871]
xref: CALOHA:TS-0448
xref: FMA:86475
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0000037 {is_inferred="true"} ! hematopoietic stem cell
is_a: PR:000050567 ! protein-containing material entity
intersection_of: CL:0000037 ! hematopoietic stem cell
@@ -13167,7 +13083,6 @@ comment: Markers are associated with mouse cells.
synonym: "CD217-positive common lymphocyte precursor" EXACT []
synonym: "CD217-positive common lymphocyte progenitor" EXACT []
synonym: "CD217-positive common lymphoid precursor" EXACT []
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0000051 {is_inferred="true"} ! common lymphoid progenitor
is_a: CL:0001030 ! CD117-positive common myeloid progenitor OR CD217-positive common lymphoid progenitor
is_a: PR:000050567 ! protein-containing material entity
@@ -13217,7 +13132,6 @@ name: CD7-negative lymphoid progenitor cell
def: "CD7-negative lymphoid progenitor cell is a lymphoid progenitor cell that is CD34-positive, CD7-negative and CD45RA-negative." [GO_REF:0000031, GOC:amm, PMID:16551251]
comment: These markers are associated with human cells. Originally described in the dendritic cell ontology (DC_CL:0000039)(PMID:19243617).
synonym: "CD7-negative lymphoid precursor" EXACT []
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0000051 {is_inferred="true"} ! common lymphoid progenitor
is_a: CL:0001012 ! CD7-negative lymphoid progenitor OR granulocyte monocyte progenitor
is_a: PR:000050567 ! protein-containing material entity
@@ -13236,7 +13150,6 @@ name: CD7-positive lymphoid progenitor cell
def: "CD7-positive lymphoid progenitor cell is a lymphoid progenitor cell that is CD34-positive, CD7-positive and is CD45RA-negative." [GO_REF:0000031, GOC:amm, GOC:tfm, PMID:16551251, PMID:19491395]
comment: These markers are associated with human cells. Originally described in the dendritic cell ontology (DC_CL:0000040)(PMID:19243617).
synonym: "CD7-positive lymphoid precursor" EXACT []
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0000051 {is_inferred="true"} ! common lymphoid progenitor
is_a: PR:000050567 ! protein-containing material entity
intersection_of: CL:0000051 ! common lymphoid progenitor
@@ -13256,7 +13169,6 @@ comment: Surface markers are for mouse cells. Originally described in the dendri
synonym: "CDP" EXACT [PMID:21219184]
synonym: "common dendritic precursor" EXACT []
synonym: "pro-DCs" EXACT [PMID:21219184]
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0000763 ! myeloid cell
is_a: CL:0001019 ! CD115-positive monocyte OR common dendritic progenitor
is_a: PR:000050567 ! protein-containing material entity
@@ -13304,12 +13216,16 @@ union_of: CL:0001025 ! Kit-positive, Sca1-positive common lymphoid progenitor
[Term]
id: CL:0001031
name: cerebellar granule cell
-def: "Granule cell that is part of the cerebellum." [GOC:mah]
+def: "An excitatory granule cell with a soma located in the granular layer of cerebellar cortex. A mature cerebellar granule cell has short dendrites with a characteristic claw-like appearance and a long axon that ascends to the molecular layer where it bifurcates (except in non-teleost fish, where it does not bifurcate) and extends mediolaterally to form parallel fibers." [doi:10.12688/f1000research.15021.1, doi:10.3389/fncir.2020.611841, GOC:mah]
+comment: It has been noted in at least some mammalian species that granule cells are the most numerous cell type in the cerebellum and in the brain, with at least 99% of all cerebellar neurons being granule cells. {xref="doi:10.3389/fncir.2020.611841"}
+synonym: "granule cell of the cerebellum" EXACT [doi:10.3389/fncir.2020.611841]
xref: BTO:0004278
-is_a: CL:0000120 {is_inferred="true"} ! granule cell
-is_a: CL:1001611 ! cerebellar neuron
+is_a: CL:0000120 ! granule cell
+is_a: CL:2000028 ! cerebellum glutamatergic neuron
+is_a: UBERON:0004121 ! ectoderm-derived structure
intersection_of: CL:0000120 ! granule cell
intersection_of: RO:0002100 UBERON:0002037 ! has soma location cerebellum
+relationship: directly_develops_from CL:0002362 ! cerebellar granule cell precursor
[Term]
id: CL:0001032
@@ -13599,7 +13515,6 @@ def: "A monocyte that expresses CD14 and is negative for the lineage markers CD3
comment: This cell type is compatible with the HIPC Lyoplate markers for 'monocyte'. Note that while CD14 is considered a reliable marker for human monocytes, it is only expressed on approximately 85% of mouse monocytes.
subset: human_reference_atlas
synonym: "monocyte" NARROW [PMID:22343568]
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0000576 ! monocyte
is_a: PR:000050567 ! protein-containing material entity
intersection_of: CL:0000576 ! monocyte
@@ -13635,7 +13550,6 @@ def: "A dendritic cell with the phenotype HLA-DRA-positive." [GOC:add, PMID:2234
comment: This cell type is compatible with the HIPC Lyoplate markers for 'dendritic cell'. The inclusion of HLA-DRA in the definition restricts this definition to human dendritic cells.
subset: human_reference_atlas
synonym: "dendritic cell" BROAD [PMID:22343568]
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0000451 ! dendritic cell
intersection_of: CL:0000451 ! dendritic cell
intersection_of: RO:0002104 PR:000002015 ! has plasma membrane part MHC class II histocompatibility antigen alpha chain DRA
@@ -13683,7 +13597,6 @@ synonym: "common myeloid precursor, CD34-positive" EXACT []
synonym: "multipotential myeloid stem cell" RELATED [ISBN:0878932437]
synonym: "myeloid stem cell" RELATED [ISBN:0878932437]
synonym: "pluripotent stem cell (bone marrow)" RELATED [ISBN:0878932437]
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0000049 ! common myeloid progenitor
is_a: CL:0011026 ! progenitor cell
is_a: PR:000050567 ! protein-containing material entity
@@ -13833,7 +13746,6 @@ synonym: "CFU-E" RELATED []
synonym: "colony forming unit erythroid" RELATED []
synonym: "erythroid stem cell" RELATED []
xref: BTO:0004911
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0000038 ! erythroid progenitor cell
is_a: PR:000050567 ! protein-containing material entity
intersection_of: CL:0000038 ! erythroid progenitor cell
@@ -13938,7 +13850,6 @@ def: "An innate lymphoid cell in the human with the phenotype CD34-negative, CD1
synonym: "CD34-negative, CD117-positive ILC" EXACT []
synonym: "CD34-negative, CD117-positive ILCP" EXACT []
synonym: "CD34-negative, CD117-positive innate lymphoid cell precusor" EXACT []
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0001082 ! immature innate lymphoid cell
intersection_of: CL:0001065 ! innate lymphoid cell
intersection_of: bearer_of PATO:0001501 ! immature
@@ -13969,7 +13880,6 @@ id: CL:0001074
name: CD34-positive, CD56-positive, CD117-positive common innate lymphoid precursor, human
def: "An innate lymphoid cell precursor in the human with the phenotype CD34-positive, CD56-positive, CD117-positive.Thie cell type may include precusors to NK cells and ILC3 cells." [GOC:add, PMID:30193847]
synonym: "CD34-positive, CD56-positive, CD117-positive CILP" EXACT []
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0001082 ! immature innate lymphoid cell
intersection_of: CL:0001065 ! innate lymphoid cell
intersection_of: bearer_of PATO:0001501 ! immature
@@ -14009,7 +13919,6 @@ id: CL:0001077
name: ILC1, human
def: "An ILC1 cell in the human with the phenotype CD56-negative, IL-7Ralpha-positive, T-bet-positive." [GOC:add, PMID:31500958]
synonym: "innate lymphoid cell 1, human" EXACT []
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0001068 ! ILC1
intersection_of: CL:0001068 ! ILC1
intersection_of: has_part PR:Q9UL17 ! T-box transcription factor TBX21 (human)
@@ -14025,7 +13934,6 @@ name: group 3 innate lymphoid cell, human
def: "A group 3 innate lymphoid cell in the human with the phenotype IL-7Ralpha-positive." [GOC:add, PMID:31500958]
subset: human_reference_atlas
synonym: "ILC3, human" EXACT []
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0001071 ! group 3 innate lymphoid cell
intersection_of: CL:0001071 ! group 3 innate lymphoid cell
intersection_of: in_taxon NCBITaxon:9606 ! Homo sapiens
@@ -14061,7 +13969,6 @@ id: CL:0001081
name: group 2 innate lymphoid cell, human
def: "A group 2 innate lymphoid cell in the human with the phenotype CD25-positive, CD127-positive, CD161-positive, and GATA-3-positive." [GOC:add, PMID:24778151, PMID:26844414]
synonym: "ILC2, human" EXACT []
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0001069 ! group 2 innate lymphoid cell
intersection_of: CL:0001069 ! group 2 innate lymphoid cell
intersection_of: has_part PR:P23771 ! trans-acting T-cell-specific transcription factor GATA-3 (human)
@@ -14118,7 +14025,6 @@ id: CL:0001200
name: lymphocyte of B lineage, CD19-positive
def: "A lymphocyte of B lineage that is CD19-positive." [GOC:add]
comment: Types of B lineage lymphocytes include B cells and antibody secreting cells (plasmablasts and plasma cells). Lymphocytes of B cell lineage can be distinguished from those of T cell lineage by their lack of CD3e (as part of the T cell receptor complex).
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0000945 ! lymphocyte of B lineage
intersection_of: CL:0000945 ! lymphocyte of B lineage
intersection_of: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon
@@ -14322,7 +14228,6 @@ id: CL:0002005
name: CD34-positive, CD38-positive megakaryocyte erythroid progenitor cell
def: "A megakaryocyte erythroid progenitor cell is CD34-positive, CD38-positive and is IL3-receptor alpha-negative and CD45RA-negative." [GOC:tfm, PMID:12615892, PMID:190227700]
comment: Markers are associated with human cell type.
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0000050 {is_inferred="true"} ! megakaryocyte-erythroid progenitor cell
is_a: PR:000050567 ! protein-containing material entity
intersection_of: CL:0000050 ! megakaryocyte-erythroid progenitor cell
@@ -14342,7 +14247,6 @@ id: CL:0002006
name: Kit-positive, CD34-negative megakaryocyte erythroid progenitor cell
def: "A megakaryocyte erythroid progenitor cell that is Kit-positive and is Sca1-negative, CD34-negative, CD90-negative, IL7r-alpha-negative and Fcgr II/III-low." [GOC:tfm, http://www.immgen.org/index_content.html, PMID:12615892, PMID:19022770]
comment: Markers are associated with mouse cells.
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0000050 {is_inferred="true"} ! megakaryocyte-erythroid progenitor cell
is_a: PR:000050567 ! protein-containing material entity
intersection_of: CL:0000050 ! megakaryocyte-erythroid progenitor cell
@@ -14416,7 +14320,6 @@ creation_date: 2010-01-19T02:51:58Z
id: CL:0002010
name: pre-conventional dendritic cell
def: "A lin-negative, MHC-II-negative, CD11c-positive, FLT3-positive cell with intermediate expression of SIRP-alpha." [GOC:tfm]
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0000763 ! myeloid cell
is_a: CL:0002031 {is_inferred="true"} ! hematopoietic lineage restricted progenitor cell
is_a: PR:000050567 ! protein-containing material entity
@@ -14462,7 +14365,6 @@ name: Kit-positive macrophage dendritic cell progenitor
def: "A progenitor cell that can give rise to plasmacytoid and myeloid dendritic cells, and to monocytes and macrophages. Marker for this cell is Kit-high, CD115-positive, CD135-positive, Cx3cr1-positive, and is Il7ra-negative." [GOC:tfm, PMID:19273628]
comment: Markers are associated with mouse cells.
synonym: "murine MDP" EXACT []
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0002009 {is_inferred="true"} ! macrophage dendritic cell progenitor
is_a: PR:000050567 ! protein-containing material entity
intersection_of: CL:0002009 ! macrophage dendritic cell progenitor
@@ -14572,7 +14474,6 @@ id: CL:0002017
name: Kit-negative, Ly-76 high orthochromatophilic erythroblasts
def: "An orthochromatophilic erythroblast that is ter119-high, CD71-low, and Kit-negative." [GOC:ak, GOC:tfm, PMID:19805084]
comment: Cell surface markers associated with mouse cells.
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0000552 {is_inferred="true"} ! orthochromatic erythroblast
is_a: PR:000050567 ! protein-containing material entity
intersection_of: CL:0000552 ! orthochromatic erythroblast
@@ -14595,7 +14496,6 @@ id: CL:0002018
name: CD71-negative, GlyA-positive orthochromatic erythroblast
def: "An erythroblast that is GlyA-positive and CD71-negative." [GOC:ak, GOC:tfm, PMID:1638021]
comment: Markers associated with human cells.
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0000552 {is_inferred="true"} ! orthochromatic erythroblast
is_a: PR:000050567 ! protein-containing material entity
intersection_of: CL:0000552 ! orthochromatic erythroblast
@@ -14638,7 +14538,6 @@ id: CL:0002021
name: GlyA-positive erythrocyte
def: "An enucleate erythrocyte that is GlyA-positive." [GOC:ak, GOC:tfm, PMID:20134094]
comment: Marker is associated with human cell types.
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0000595 {is_inferred="true"} ! enucleate erythrocyte
is_a: PR:000050567 ! protein-containing material entity
intersection_of: CL:0000595 ! enucleate erythrocyte
@@ -14653,7 +14552,6 @@ id: CL:0002022
name: Ly-76 high positive erythrocyte
def: "An enucleate erythrocyte that is Lyg-76-high." [GOC:ak, GOC:tfm, PMID:19805084]
comment: Marker is associated with mouse cell types.
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0000595 {is_inferred="true"} ! enucleate erythrocyte
is_a: PR:000050567 ! protein-containing material entity
intersection_of: CL:0000595 ! enucleate erythrocyte
@@ -14668,7 +14566,6 @@ id: CL:0002023
name: CD34-positive, CD41-positive, CD42-positive megakaryocyte progenitor cell
def: "A megakaroycotye progenitor cell that is CD34-positive, CD41-positive and CD42-positive on the cell surface." [GOC:ak, GOC:tfm, PMID:15232614]
comment: Markers are associated with human cell type.
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0000553 {is_inferred="true"} ! megakaryocyte progenitor cell
is_a: PR:000050567 ! protein-containing material entity
intersection_of: CL:0000553 ! megakaryocyte progenitor cell
@@ -14687,7 +14584,6 @@ id: CL:0002024
name: Kit-positive megakaryocyte progenitor cell
def: "A megakaryocyte progenitor cell that is Kit-positive, CD41-positive, CD9-positive, Sca-1-negative, IL7ralpha-negative, CD150-negative, and Fcgamma receptor II/III-low." [GOC:ak, GOC:tfm, PMID:16951553]
comment: Markers are associated with mouse cells.
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0000553 {is_inferred="true"} ! megakaryocyte progenitor cell
is_a: PR:000050567 ! protein-containing material entity
intersection_of: CL:0000553 ! megakaryocyte progenitor cell
@@ -14714,7 +14610,6 @@ id: CL:0002025
name: CD34-positive, CD41-positive, CD42-negative megakaryocyte progenitor cell
def: "A megakaryocyte progenitor cell that is CD34-positive, CD41-positive, and CD42-negative." [GOC:ak, GOC:tfm, PMID:15232614]
comment: Markers are commonly associated with human cells.
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0000553 {is_inferred="true"} ! megakaryocyte progenitor cell
is_a: PR:000050567 ! protein-containing material entity
intersection_of: CL:0000553 ! megakaryocyte progenitor cell
@@ -14733,7 +14628,6 @@ id: CL:0002026
name: CD34-negative, CD41-positive, CD42-positive megakaryocyte cell
def: "A megakaryocyte progenitor cell that is CD34-negative, CD41-positive and CD42-positive." [GOC:ak, GOC:tfm, PMID:15232614]
comment: Markers are commonly associated with human cells.
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0000556 {is_inferred="true"} ! megakaryocyte
is_a: PR:000050567 ! protein-containing material entity
intersection_of: CL:0000556 ! megakaryocyte
@@ -14752,7 +14646,6 @@ id: CL:0002027
name: CD9-positive, CD41-positive megakaryocyte cell
def: "A megakaryocyte cell with is CD9-positive and CD41-positive." [GOC:tfm]
comment: Markers are commonly associated with mouse cells.
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0000556 {is_inferred="true"} ! megakaryocyte
is_a: PR:000050567 ! protein-containing material entity
intersection_of: CL:0000556 ! megakaryocyte
@@ -14770,7 +14663,6 @@ name: basophil mast progenitor cell
def: "A cell type that can give rise to basophil and mast cells. This cell is CD34-positive, CD117-positive, CD125-positive, FceRIa-negative, and T1/ST2-negative, and expresses Gata-1, Gata-2, C/EBPa" [GOC:ak, GOC:dsd, GOC:tfm, PMCID:PMC1312421]
comment: There may be an intermediate cell type. These cells also CD13-positive, CD16-positive, CD32-positive, and integrin beta 7-positive. Transcription factors: GATA1-positive, MCP-1-positive, mitf-positive, PU.1-positive, and CEBP/a-low.
synonym: "BMCP" EXACT []
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0000763 ! myeloid cell
is_a: CL:0002191 ! granulocytopoietic cell
is_a: PR:000050567 ! protein-containing material entity
@@ -14835,7 +14727,6 @@ id: CL:0002031
name: hematopoietic lineage restricted progenitor cell
def: "A hematopoietic progenitor cell that is capable of developing into only one lineage of hematopoietic cells." [GOC:tfm, PMID:19022770]
subset: blood_and_immune_upper_slim
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:0008001 ! hematopoietic precursor cell
intersection_of: CL:0000988 ! hematopoietic cell
intersection_of: bearer_of PATO:0001400 ! unipotent
@@ -14851,7 +14742,6 @@ name: hematopoietic oligopotent progenitor cell
def: "A hematopoietic oligopotent progenitor cell that has the ability to differentiate into limited cell types but lacks lineage cell markers and self renewal capabilities." [GOC:tfm, https://orcid.org/0000-0001-5208-3432, PMID:19022770]
comment: This cell type is intended to be compatible with any vertebrate hematopoietic oligopotent progenitor cell. For mammalian hematopoietic oligopotent progenitor cells known to be lineage-negative, please use the term 'hematopoietic oligopotent progenitor cell' (CL_0001060).
subset: blood_and_immune_upper_slim
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:0008001 ! hematopoietic precursor cell
intersection_of: CL:0000988 ! hematopoietic cell
intersection_of: bearer_of PATO:0001401 ! oligopotent
@@ -15106,7 +14996,6 @@ def: "A pro-B cell that is CD45R/B220-positive, CD43-positive, HSA-low, BP-1-neg
comment: Markers associated with mouse cells.
synonym: "fraction A" BROAD []
synonym: "pre pro B cell" RELATED []
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0000826 {is_inferred="true"} ! pro-B cell
intersection_of: CL:0000826 ! pro-B cell
intersection_of: CL:4030046 PR:000002039 ! lacks_plasma_membrane_part glutamyl aminopeptidase
@@ -15131,7 +15020,6 @@ id: CL:0002046
name: early pro-B cell
def: "A pro-B cell that is CD22-positive, CD34-positive, CD38-positive and TdT-positive (has TdT activity). Pre-BCR is expressed on the cell surface. Cell is CD19-negative, CD20-negative, complement receptor type 2-negative and CD10-low. D-to-J recombination of the heavy chain occurs at this stage." [GOC:dsd, GOC:tfm, PMID:18432934]
comment: Markers are commonly associated with human cells. These cells are also reportedly CD21-negative. Transcription factors: PU.1-positive, Ikaros-positive, E2A-positive, and PAX5-positive.
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0000826 {is_inferred="true"} ! pro-B cell
intersection_of: CL:0000826 ! pro-B cell
intersection_of: CL:4030046 PR:000001002 ! lacks_plasma_membrane_part CD19 molecule
@@ -15500,7 +15388,6 @@ synonym: "type II alveolar epithelial cell" EXACT []
synonym: "type II alveolocyte" EXACT []
xref: BTO:0000538
xref: FMA:62501
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:0000157 ! surfactant secreting cell
is_a: CL:0000322 ! pneumocyte
is_a: CL:1000272 ! lung secretory cell
@@ -15665,7 +15552,6 @@ id: CL:0002076
name: endo-epithelial cell
def: "An epithelial cell derived from endoderm." [FMA:69075, GOC:tfm]
xref: FMA:69075
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:0000066 ! epithelial cell
is_a: CL:0002371 ! somatic cell
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
@@ -15677,7 +15563,6 @@ id: CL:0002077
name: ecto-epithelial cell
def: "An epithelial cell derived from ectoderm." [FMA:69074, GOC:tfm]
xref: FMA:69074
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:0000066 ! epithelial cell
is_a: CL:0002371 ! somatic cell
intersection_of: CL:0000066 ! epithelial cell
@@ -15692,7 +15577,6 @@ name: meso-epithelial cell
def: "Epithelial cell derived from mesoderm or mesenchyme." [FMA:69076, GOC:tfm]
synonym: "epithelial mesenchymal cell" EXACT []
xref: FMA:69076
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:0000066 ! epithelial cell
is_a: CL:0002371 ! somatic cell
intersection_of: CL:0000066 ! epithelial cell
@@ -15846,7 +15730,6 @@ id: CL:0002089
name: group 2 innate lymphoid cell, mouse
def: "A group 2 innate lymphoid cell in the mouse capable of secreting IL-13 in response to a helminth infection. This cell is lineage-negative, ICOS-positive, IL1RL1-positive, IL7Ralpha-positive, and IL17Br-positive." [GOC:add, GOC:tfm, PMID:20200518]
synonym: "nuocyte" BROAD []
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0001069 ! group 2 innate lymphoid cell
intersection_of: CL:0001069 ! group 2 innate lymphoid cell
intersection_of: capable_of GO:0002830 ! positive regulation of type 2 immune response
@@ -16718,7 +16601,6 @@ def: "The dead keratin-filled squamous cell of the stratum corneum. This cell ty
subset: human_reference_atlas
xref: BTO:0001943
xref: FMA:68650
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:0000225 ! anucleate cell
is_a: CL:0000311 ! keratin accumulating cell
is_a: CL:0000548 ! animal cell
@@ -16971,7 +16853,6 @@ synonym: "folliculostellate cell of pars anterior of adenohypophysis" EXACT []
xref: FMA:83102
is_a: CL:0000642 {is_inferred="true"} ! folliculostellate cell
is_a: CL:0000710 ! neurecto-epithelial cell
-is_a: CL:2000004 ! pituitary gland cell
intersection_of: CL:0000642 ! folliculostellate cell
intersection_of: part_of UBERON:0006964 ! pars distalis of adenohypophysis
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
@@ -17544,7 +17425,6 @@ name: secondary lens fiber
def: "A lens fiber cell that develops from primary lens fiber; located towards the center of lens; cell organelles are normally degraded or in the process of being degraded." [GOC:tfm, ISBN:0517223651]
subset: human_reference_atlas
synonym: "secondary lens fibre" EXACT []
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:0011004 ! lens fiber cell
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: develops_from CL:0002228 ! primary lens fiber
@@ -17579,7 +17459,6 @@ def: "An elongating cell that rapidly obliterates the lumen of the lens vesicle.
subset: human_reference_atlas
synonym: "primary lens fibre" EXACT []
xref: FMA:70613
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:0011004 ! lens fiber cell
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: develops_from CL:0002223 ! anterior lens cell
@@ -18696,7 +18575,6 @@ id: CL:0002318
name: peripheral blood mesothelial cell
def: "A mesothelial cell capable of circulating in the blood by first losing its squamous character. This cell can incorporate into the regenerating mesothelium." [GOC:tfm, PMID:14592528]
xref: FMA:86712
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:0000081 ! blood cell
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: develops_from CL:0000077 ! mesothelial cell
@@ -18813,7 +18691,6 @@ name: luminal epithelial cell of mammary gland
def: "A mammary epithelial cell that occurs in the lumen of the ductal and alveoli structure in the breast." [GOC:tfm, PMID:19022771]
synonym: "mature luminal cell" BROAD [PMID:21930782]
xref: FMA:73280
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:0000069 ! branched duct epithelial cell
is_a: CL:0002327 ! mammary gland epithelial cell
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
@@ -18933,7 +18810,6 @@ name: CD56-positive, CD161-positive immature natural killer cell, human
def: "A natural killer cell that is developmentally immature, has the phenotype CD34-negative, CD56-positive, CD117-positive, CD122-positive,and CD161-positive." [GO_REF:0000031, GOC:add, ISBN:0781735149, PMID:12457618]
comment: Human markers; killer cell immunoglobulin-like receptor 2DL1 is used as a representative example (PRO at this time lacks a KIR superfamily).
synonym: "p-NK" RELATED [PMID:12457618]
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0000823 ! immature natural killer cell
intersection_of: CL:0000823 ! immature natural killer cell
intersection_of: CL:4030046 PR:000001003 ! lacks_plasma_membrane_part CD34 molecule
@@ -18998,7 +18874,6 @@ name: decidual natural killer cell, human
def: "A natural killer cell subset that is found in the decidual of the uterus and is CD56-high, Galectin-1-positive and CD16-negative. This cell type represents the most abundant immune cell type in the decidual during the first trimester of pregnancy." [PMID:14568979, PMID:19800965]
synonym: "decidual NK cell" EXACT []
synonym: "dNK cell" EXACT []
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0000824 ! mature natural killer cell
intersection_of: CL:0000824 ! mature natural killer cell
intersection_of: CL:4030046 PR:000001483 ! lacks_plasma_membrane_part low affinity immunoglobulin gamma Fc region receptor III
@@ -19018,7 +18893,6 @@ name: CD56-negative, CD161-positive immature natural killer cell, human
def: "A natural killer cell that is developmentally immature, has the phenotype CD34-negative, CD56-negative, CD117-positive, CD122-positive,and CD161-positive." [GO_REF:0000031, GOC:add, ISBN:0781735149, PMID:12457618]
comment: Human markers; killer cell immunoglobulin-like receptor 2DL1 is used as a representative example (PRO at this time lacks a KIR superfamily).
synonym: "p-NK" RELATED [PMID:12457618]
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0000823 ! immature natural killer cell
intersection_of: CL:0000823 ! immature natural killer cell
intersection_of: CL:4030046 PR:000001003 ! lacks_plasma_membrane_part CD34 molecule
@@ -19042,7 +18916,6 @@ name: CD27-low, CD11b-low immature natural killer cell, mouse
def: "An immature natural killer cell that is NK1.1-positive, DX5-positive, Ly49-positive, CD27-low and CD11b-low. This cell type is found in high numbers in the liver." [GOC:tfm, http:www.immgen.org/index_content.html, PMID:19949422]
comment: Markers are associated with mouse cells.
synonym: "preNK.BM" BROAD []
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0000823 ! immature natural killer cell
intersection_of: CL:0000823 ! immature natural killer cell
intersection_of: in_taxon NCBITaxon:10090 ! Mus musculus
@@ -19065,7 +18938,6 @@ creation_date: 2010-09-20T04:41:01Z
id: CL:0002346
name: Dx5-negative, NK1.1-positive immature natural killer cell, mouse
def: "An immature natural killer cell that is NK1.1-positive and DX-5 negative." [GOC:tfm, PMID:12766763]
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0000823 ! immature natural killer cell
intersection_of: CL:0000823 ! immature natural killer cell
intersection_of: CL:4030046 PR:000001008 ! lacks_plasma_membrane_part integrin alpha-2
@@ -19081,7 +18953,6 @@ creation_date: 2010-09-21T10:11:44Z
id: CL:0002347
name: CD27-high, CD11b-high natural killer cell, mouse
def: "A mature natural killer cell that is CD27-high and CD11b-high. This cell type is capable of interferon-gamma secretion." [GOC:tfm, PMID:19949422]
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0000824 ! mature natural killer cell
intersection_of: CL:0000824 ! mature natural killer cell
intersection_of: capable_of GO:0032609 ! type II interferon production
@@ -19099,7 +18970,6 @@ creation_date: 2010-09-21T10:19:49Z
id: CL:0002348
name: CD27-low, CD11b-high natural killer cell, mouse
def: "A CD27-low, CD11b-high natural killer cell that has a higher threshold of activation due to higher expression of inhibitory receptors." [GOC:tfm, PMID:1994922]
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0000824 ! mature natural killer cell
intersection_of: CL:0000824 ! mature natural killer cell
intersection_of: in_taxon NCBITaxon:10090 ! Mus musculus
@@ -19116,7 +18986,6 @@ creation_date: 2010-09-21T10:19:54Z
id: CL:0002349
name: CD27-high, CD11b-low natural killer cell, mouse
def: "A natural killer cell that is CD27-high and CD11b-low." [GOC:tfm, PMID:1994922]
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0000824 ! mature natural killer cell
intersection_of: CL:0000824 ! mature natural killer cell
intersection_of: in_taxon NCBITaxon:10090 ! Mus musculus
@@ -19172,7 +19041,6 @@ creation_date: 2010-09-22T09:05:13Z
id: CL:0002353
name: fetal liver hematopoietic progenitor cell
def: "A hematopoietic stem cell that resides in the fetal liver. In mice, this cell type is first observed at E10.5. This cell type is MHC-positive, HSA-positive, AA4.1-positive, CD45-positive, Sca-1 positive, CD150-positive, CD48-negative and CD244-negative." [GOC:tfm, ISBN:978-1-60327-346-6, PMID:16569764]
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0002352 {is_inferred="true"} ! gestational hematopoietic stem cell
is_a: PR:000050567 ! protein-containing material entity
intersection_of: CL:0002352 ! gestational hematopoietic stem cell
@@ -19201,7 +19069,6 @@ id: CL:0002354
name: yolk sac hematopoietic stem cell
def: "A hematopoietic stem found in the yolk sac. In mice, this cell type is Sca-1-negative, CD45-negative, MHC-negative, HSA-positive, AA4.1-positive, CD44-positive." [doi:10.1097/MOH.0b013e3282f97ae1, GOC:tfm]
synonym: "hemangioblast precursor" EXACT []
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0002352 {is_inferred="true"} ! gestational hematopoietic stem cell
is_a: PR:000050567 ! protein-containing material entity
intersection_of: CL:0002352 ! gestational hematopoietic stem cell
@@ -19311,7 +19178,6 @@ name: primitive erythroid progenitor
def: "A progenitor cell that is capable of forming colonies of primitive erythrocytes in the blood island of the yolk sac. First arrive at E7.5 in mouse and expresses CD41." [GOC:tfm, ISBN:0813817986, PMID:20711979]
synonym: "EryP-CFC" EXACT []
synonym: "inner blood island hemangioblast" EXACT []
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0002417 {is_inferred="true"} ! primitive erythroid lineage cell
is_a: PR:000050567 ! protein-containing material entity
intersection_of: CL:0002417 ! primitive erythroid lineage cell
@@ -19323,10 +19189,15 @@ creation_date: 2010-09-22T10:47:28Z
[Term]
id: CL:0002362
-name: granule cell precursor
-def: "A cell located in the outermost proliferative zone of the external germinal layer that can differentiate into astroglial cells and granule cells. This cell type is glial fibrillary acidic protein-positive and NK1-positive." [GOC:tfm, PMID:14745007]
+name: cerebellar granule cell precursor
+def: "A cell located in the outermost proliferative zone of the external germinal layer that can differentiate into astroglial cells and granule cells. This cell type is glial fibrillary acidic protein-positive and HNK1-positive." [GOC:tfm, PMID:14745007]
+synonym: "GCP" RELATED abbreviation [doi:10.3389/fncir.2020.611841]
+synonym: "granule cell precursor" BROAD [doi:10.3389/fncir.2020.611841]
+synonym: "granule cell progenitor" BROAD [doi:10.3389/fncir.2020.611841]
is_a: CL:0000031 ! neuroblast (sensu Vertebrata)
+is_a: CL:0002319 ! neural cell
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
+relationship: part_of UBERON:0009841 ! upper rhombic lip
creation_date: 2010-09-22T01:40:44Z
[Term]
@@ -19477,7 +19348,6 @@ id: CL:0002374
name: ear hair cell
def: "A hair cell of the ear that contains the organs of balance and hearing." [GOC:dph, GOC:tfm, ISBN:0192801023]
synonym: "ear receptor cell" EXACT []
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:0000006 ! neuronal receptor cell
is_a: CL:0000855 ! sensory hair cell
intersection_of: CL:0000855 ! sensory hair cell
@@ -19982,7 +19852,6 @@ id: CL:0002418
name: hemangioblast
def: "A pluripotent cell in the yolk sac that can give rise to mesenchymal cells including erythrocytes and endothelial cells." [GOC:tfm, ISBN:0813817986, PMID:11495698]
xref: MESH:D055018
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:0000222 ! mesodermal cell
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: develops_from CL:0002354 ! yolk sac hematopoietic stem cell
@@ -19995,7 +19864,6 @@ def: "A T cell that expresses a T cell receptor complex and has completed T cell
synonym: "CD3e-positive T cell" EXACT []
synonym: "CD3epsilon T cell" RELATED []
synonym: "mature T-cell" EXACT []
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0000084 {is_inferred="true"} ! T cell
intersection_of: CL:0000084 ! T cell
intersection_of: output_of GO:0045058 ! T cell selection
@@ -20079,7 +19947,6 @@ comment: ETPs are reportedly CD1a-negative, CD4-negative, CD7-positive, CD8a-neg
subset: human_reference_atlas
synonym: "ETP" EXACT []
synonym: "preT.ETP.Th" EXACT []
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0000827 {is_inferred="true"} ! pro-T cell
is_a: PR:000050567 ! protein-containing material entity
intersection_of: CL:0000827 ! pro-T cell
@@ -20302,7 +20169,6 @@ def: "A mature NK cell that is NK1.1-positive." [GOC:tfm]
comment: Note: Nk1.1 expression is restricted to C57BL strains of laboratory mice.
synonym: "NK.sp" EXACT []
synonym: "NK1.1-positive NK cell" EXACT []
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0000824 ! mature natural killer cell
intersection_of: CL:0000824 ! mature natural killer cell
intersection_of: in_taxon NCBITaxon:10090 ! Mus musculus
@@ -20801,7 +20667,6 @@ name: bone marrow macrophage
def: "A tissue-resident macrophage located in the bone marrow. This cell type is B220-negative, CD3e-negative, Ly-6C-negative, CD115-positive, F4/80-positive." [GOC:tfm, http://www.immgen.org/index_content.html]
synonym: "MF.BM" RELATED []
xref: BTO:0004732
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0000864 {is_inferred="true"} ! tissue-resident macrophage
is_a: CL:1001610 ! bone marrow hematopoietic cell
is_a: PR:000050567 ! protein-containing material entity
@@ -20823,7 +20688,6 @@ creation_date: 2010-11-23T04:19:25Z
id: CL:0002477
name: adipose macrophage
def: "A macrophage located in adipose tissue that is CD45-positive, CD11c-positive, and SIRPa-positive." [GOC:tfm]
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0000864 {is_inferred="true"} ! tissue-resident macrophage
is_a: PR:000050567 ! protein-containing material entity
intersection_of: CL:0000864 ! tissue-resident macrophage
@@ -23056,7 +22920,6 @@ creation_date: 2011-08-16T01:49:32Z
id: CL:0002672
name: retinal progenitor cell
def: "A multi-fate stem cell that can give rise to different retinal cell types including rod and cone cells." [GOC:tfm, PMID:20959166, PMID:21148186]
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:0000048 ! multi fate stem cell
relationship: dc-contributor https://orcid.org/0000-0003-1980-3228
relationship: develops_from CL:0000133 ! neurectodermal cell
@@ -23134,7 +22997,6 @@ id: CL:0002679
name: natural helper lymphocyte
def: "A lymphocyte found in adipose tissue that lacks lineage markers of other lymphocytes but is capable of mediating TH2 cytokine responses. This cell type is found in fat associated lymphoid clusters, proliferates in response to IL2 and produce large amounts of TH2 cytokines such as IL5, IL6 and IL13" [GOC:tfm, PMID:20023630]
subset: blood_and_immune_upper_slim
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0000542 {is_inferred="true"} ! lymphocyte
intersection_of: CL:0000542 ! lymphocyte
intersection_of: CL:4030046 GO:0042105 ! lacks_plasma_membrane_part alpha-beta T cell receptor complex
@@ -23961,6 +23823,7 @@ name: H1 horizontal cell
namespace: cell
def: "A horizontal cell with a large cell body, thick dendrites, and a large dendritic arbor." [PMID:8571130]
synonym: "A Horizontal Cell" EXACT []
+synonym: "H1" RELATED abbreviation [doi:10.1038/s41598-020-66092-9]
is_a: CL:0000745 ! retina horizontal cell
relationship: CL:4030045 GO:0030424 ! lacks_part axon
property_value: dc-contributor "https://orcid.org/0000-0001-7258-9596" xsd:string
@@ -23972,6 +23835,7 @@ name: H2 horizontal cell
namespace: cell
def: "A horizontal cell with a small cell body, thin dendrites, and small dendritic arbor." [PMID:8571130]
synonym: "B Horizontal Cell" EXACT []
+synonym: "H2" RELATED abbreviation [doi:10.1038/s41598-020-66092-9]
is_a: CL:0000745 ! retina horizontal cell
relationship: RO:0002120 GO:0044316 ! synapsed to cone cell pedicle
property_value: dc-contributor "https://orcid.org/0000-0001-7258-9596" xsd:string
@@ -24374,7 +24238,6 @@ id: CL:0005000
name: spinal cord interneuron
def: "A CNS interneuron located in the spinal cord." [CL:CVS]
comment: Is_a interneuron, part_of UBERON:0002240.
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:0000402 {is_inferred="true"} ! CNS interneuron
intersection_of: CL:0000099 ! interneuron
intersection_of: RO:0002100 UBERON:0002240 ! has soma location spinal cord
@@ -24591,7 +24454,6 @@ def: "Cranial motor neuron which innervates muscles derived from the branchial (
synonym: "branchi motor neuron" EXACT []
synonym: "special visceral motor neuron" EXACT []
xref: PMID:14699587
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:0015000 ! cranial motor neuron
intersection_of: CL:0015000 ! cranial motor neuron
intersection_of: RO:0002130 UBERON:0004164 ! has synaptic terminal in branchiomeric muscle
@@ -24614,7 +24476,6 @@ name: visceromotor neuron
def: "A motor neuron that synapses to parasympathetic neurons that innervate tear glands, sweat glands, and the smooth muscles and glands of the pulmonary, cardiovascular, and gastrointestinal systems." [ZFIN:CVS]
comment: Note that these neurons do not synapse directly onto muscles
synonym: "general visceral motor neuron" EXACT []
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:0000100 ! motor neuron
relationship: RO:0002120 CL:0011102 ! synapsed to parasympathetic neuron
@@ -24630,7 +24491,6 @@ id: CL:0007000
name: preameloblast
def: "Skeletogenic cell that has the potential to develop into an ameloblast. Located in the inner enamel epithelium, these cells elongate, their nuclei shift distally (away from the dental papilla), and their cytoplasm becomes filled with organelles needed for synthesis and secretion of enamel proteins." [GO_REF:0000034, PMCID:PMC2737325]
comment: unsure of neural crest contribution. In VSAO we have develops_from CL:0000008
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:0000055 ! non-terminally differentiated cell
is_a: CL:0000548 ! animal cell
relationship: adjacent_to UBERON:0001763 ! odontogenic papilla
@@ -24675,7 +24535,6 @@ creation_date: 2012-06-15T05:15:11Z
id: CL:0007004
name: premigratory neural crest cell
def: "Cell that is part of the neural crest region of the neuroepithelium, prior to migration. Note that not all premigratory neural crest cells may become migratory neural crest cells." [UBERONREF:0000002]
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:0011012 ! neural crest cell
relationship: dc-contributor https://orcid.org/0000-0001-9114-8737
relationship: develops_from CL:0000133 ! neurectodermal cell
@@ -24687,7 +24546,6 @@ id: CL:0007005
name: notochordal cell
def: "Cell that is part of the notochord." [GO_REF:0000034]
comment: NOTE: TO DO, notochord development still needs work.
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:0000548 ! animal cell
relationship: dc-contributor https://orcid.org/0000-0001-9114-8737
relationship: develops_from CL:0007006 ! chordamesodermal cell
@@ -25244,7 +25102,6 @@ id: CL:0008039
name: lower motor neuron
def: "The motor neurons of vertebrates that directly innervate skeletal muscles. They receive input from upper motor neurons." [Wikipedia:Lower_motor_neuron&oldid=952547294]
xref: FMA:84632
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:0005024 ! somatomotor neuron
relationship: dc-contributor https://orcid.org/0000-0002-7073-9172
relationship: in_taxon NCBITaxon:7742 ! Vertebrata
@@ -25280,7 +25137,6 @@ creation_date: 2020-09-26T21:07:01Z
id: CL:0008048
name: upper motor neuron
def: "A glutamatergic motor neuron with a soma in the brainstem or cerebral cortex. They do not synapse directly to muscles but rather to lower motor neurons, which do. They are the main controllers of voluntary movement." [Wikipedia:Upper_motor_neuron&oldid=943248837]
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:0000100 ! motor neuron
is_a: CL:0000679 ! glutamatergic neuron
relationship: dc-contributor https://orcid.org/0000-0002-7073-9172
@@ -25308,7 +25164,6 @@ id: CL:0009000
name: sensory neuron of spinal nerve
def: "A sensory neuron of the spinal nerve that senses body position and sends information about how much the muscle is stretched to the spinal cord." [GOC:nv, GOC:pr]
synonym: "spinal sensory neuron" EXACT []
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:3000004 ! peripheral sensory neuron
intersection_of: CL:0000101 ! sensory neuron
intersection_of: RO:0002100 UBERON:0001780 ! has soma location spinal nerve
@@ -25426,7 +25281,6 @@ synonym: "TACs" RELATED []
synonym: "transient amplifying cell" EXACT []
synonym: "transit amplifying progenitor cell" EXACT [PMID:30827895]
synonym: "transit-amplifying cell" EXACT []
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:0000003 ! native cell
relationship: dc-contributor https://orcid.org/0000-0002-2825-0621
relationship: develops_from CL:0000034 ! stem cell
@@ -26408,7 +26262,7 @@ is_a: CL:0000115 ! endothelial cell
intersection_of: CL:0000115 ! endothelial cell
intersection_of: part_of UBERON:0003456 ! respiratory system lymphatic vessel
relationship: dc-contributor https://orcid.org/0000-0002-2825-0621
-relationship: part_of UBERON:0003456 ! respiratory system lymphatic vessel
+relationship: part_of UBERON:0003529 ! respiratory system lymphatic vessel endothelium
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: dcterms-date "2021-12-03T14:00:44Z" xsd:dateTime
@@ -26891,7 +26745,6 @@ relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
id: CL:0010009
name: camera-type eye photoreceptor cell
synonym: "camera type eye photoreceptor cell" EXACT []
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:0000287 ! eye photoreceptor cell
intersection_of: CL:0000210 ! photoreceptor cell
intersection_of: part_of UBERON:0000019 ! camera-type eye
@@ -26924,7 +26777,6 @@ synonym: "cortical neuron" EXACT []
synonym: "neuron of cerebral cortex" EXACT []
xref: BTO:0004102
xref: FMA:84104
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:2000029 ! central nervous system neuron
intersection_of: CL:0000540 ! neuron
intersection_of: RO:0002100 UBERON:0000956 ! has soma location cerebral cortex
@@ -26990,7 +26842,6 @@ id: CL:0010022
name: cardiac neuron
def: "A neuron that has its soma in the heart." [PMID:12486170, PMID:29265764]
comment: This term is used in 3 GO terms that were created as part of the heart development focus project.
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:0000540 ! neuron
intersection_of: CL:0000540 ! neuron
intersection_of: RO:0002100 UBERON:0000948 ! has soma location heart
@@ -27011,7 +26862,6 @@ relationship: RO:0002100 UBERON:0002256 ! has soma location dorsal horn of spina
id: CL:0011001
name: spinal cord motor neuron
def: "A motor neuron that passes from the spinal cord toward or to a muscle and conducts an impulse that causes movement." [GOC:nv]
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:0000100 {is_inferred="true"} ! motor neuron
is_a: CL:2000029 ! central nervous system neuron
intersection_of: CL:0000100 ! motor neuron
@@ -27156,7 +27006,6 @@ name: lymphoid tissue–inducer cell
def: "A group 3 innate lymphoid cell that express ROR gamma t and IL-7R alpha in the absence of lineage markers (e.g. CD3, CD19, B220, CD11c, Gr-1), with the functional ability to interact with mesenchymal cells through lymphotoxin and tumor necrosis factor. Lymphoid tissue-inducer cells are key to the development of lymph nodes and Peyer’s patches." [GOC:add, PMID:19029905, PMID:21601793, PMID:27935637, PMID:29454785, PMID:9354470]
synonym: "LTi" EXACT []
synonym: "lymphoid tissue inducer cell" EXACT []
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0001071 ! group 3 innate lymphoid cell
relationship: dc-contributor https://orcid.org/0000-0001-5208-3432
relationship: RO:0002104 PR:000001869 ! has plasma membrane part interleukin-7 receptor subunit alpha
@@ -27206,7 +27055,6 @@ name: CD25+ mast cell
def: "A mast cell that is CD25+." []
comment: Mast cells do not normally express CD25, but neoplastic mast cells may be CD25-positive.
synonym: "CD25+ neoplastic mast cell" EXACT []
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0000548 ! animal cell
is_a: CL:0001063 ! neoplastic cell
is_a: PR:000050567 ! protein-containing material entity
@@ -27242,7 +27090,6 @@ relationship: dc-contributor https://orcid.org/0000-0001-5208-3432
id: CL:0011026
name: progenitor cell
def: "A precursor cell that has a tendency to differentiate into a specific type of cell. They are descendants of stem cells, only they are more constrained in their differentiation potential or capacity for self-renewal, and are often more limited in both senses." [https://doi.org/10.1016/B978-0-12-409503-8.00002-0, ISBN:978-1-62808-994-3]
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:0011115 ! precursor cell
intersection_of: CL:0011115 ! precursor cell
intersection_of: develops_from CL:0000034 ! stem cell
@@ -27350,7 +27197,6 @@ name: interplexiform cell
def: "A type of interneuron in the retinal inner nuclear layer which\ncarries information from the inner plexiform layer and the outer\nplexiform layer." [GOC:NV, PMID:12771169]
comment: Need to MIREOT retinal inner nuclear layer (part of)
subset: eye_upper_slim
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:0000099 ! interneuron
is_a: CL:0009004 ! retinal cell
relationship: part_of UBERON:0001791 ! inner nuclear layer of retina
@@ -27438,7 +27284,6 @@ replaced_by: CL:0011003
id: CL:0011113
name: spiral ganglion neuron
def: "Neuron found in the spiral ganglion." [GOC:NV]
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:0000540 ! neuron
intersection_of: CL:0000540 ! neuron
intersection_of: RO:0002100 UBERON:0000395 ! has soma location cochlear ganglion
@@ -27942,7 +27787,6 @@ replaced_by: CL:4030005
[Term]
id: CL:1000001
name: retrotrapezoid nucleus neuron
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:2000029 ! central nervous system neuron
intersection_of: CL:0000540 ! neuron
intersection_of: RO:0002100 UBERON:0009918 ! has soma location retrotrapezoid nucleus
@@ -29904,7 +29748,6 @@ name: cholangiocyte
def: "An epithelial cell that is part of the bile duct. Cholangiocytes contribute to bile secretion via net release of bicarbonate and water. They are cuboidal epithelium in the small interlobular bile ducts, but become columnar and mucus secreting in larger bile ducts approaching the porta hepatis and the extrahepatic ducts." [GOC:tfm, PMID:16550043, PMID:18356246]
synonym: "epithelial cell of bile duct" EXACT []
xref: FMA:86481
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:0000069 {is_inferred="true"} ! branched duct epithelial cell
intersection_of: CL:0000069 ! branched duct epithelial cell
intersection_of: capable_of GO:0015106 ! bicarbonate transmembrane transporter activity
@@ -30144,7 +29987,6 @@ relationship: part_of UBERON:0000056 ! ureter
id: CL:1000606
name: kidney nerve cell
xref: KUPO:0001015
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:1000500 ! kidney interstitial cell
is_a: CL:2000032 ! peripheral nervous system neuron
intersection_of: CL:0000540 ! neuron
@@ -31124,7 +30966,6 @@ relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
id: CL:1001434
name: olfactory bulb interneuron
def: "A neuron residing in the olfactory bulb that serve to process and refine signals arising from olfactory sensory neurons" [PMID:18603310]
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:0000101 ! sensory neuron
is_a: CL:0000402 ! CNS interneuron
intersection_of: CL:0000099 ! interneuron
@@ -31164,7 +31005,6 @@ id: CL:1001451
name: sensory neuron of dorsal root ganglion
def: "A sensory neuron of the dorsal root ganglia that senses body position and sends information about how much the muscle is stretched to the spinal cord." [MP:0004297]
synonym: "proprioceptive neuron" EXACT [MP:0004297]
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:0000006 ! neuronal receptor cell
is_a: CL:4023168 ! somatosensory neuron
intersection_of: CL:0000101 ! sensory neuron
@@ -31182,7 +31022,6 @@ synonym: "gamma-aminobutyric acid ergic spiny projection neuron" EXACT [doi:10.1
synonym: "medium-sized densely spiny neuron" RELATED [BTO:0004778]
synonym: "striatal medium spiny neuron" EXACT [GO:0021773]
xref: BTO:0004778
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:0000617 ! GABAergic neuron
is_a: CL:2000029 ! central nervous system neuron
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
@@ -31199,7 +31038,6 @@ relationship: RO:0002100 UBERON:0004186 ! has soma location olfactory bulb mitra
id: CL:1001503
name: olfactory bulb tufted cell
def: "The principal glutaminergic neuron located in the outer third of the external plexiform layer of the olfactory bulb; a single short primary dendrite traverses the outer external plexiform layer and terminates within an olfactory glomerulus in a tuft of branches, where it receives the input from olfactory receptor neuron axon terminals; axons of the tufted cells transfer information to a number of areas in the brain, including the piriform cortex, entorhinal cortex, olfactory tubercle, and amygdala." [MP:0009955]
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:0000540 ! neuron
relationship: part_of UBERON:0005376 ! olfactory bulb external plexiform layer
@@ -31249,7 +31087,6 @@ relationship: part_of UBERON:0001160 ! fundus of stomach
id: CL:1001561
name: vomeronasal sensory neuron
def: "Chemosensitive cells that innervate the vomernasal organ epithelium and are responsible for receiving and transmitting pheromone signals." [MP:0011679]
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:0000101 ! sensory neuron
intersection_of: CL:0000101 ! sensory neuron
intersection_of: RO:0002100 UBERON:0002255 ! has soma location vomeronasal organ
@@ -31443,7 +31280,6 @@ synonym: "lateral ventricle neural cell" RELATED [CALOHA:TS-1261]
synonym: "lateral ventricle neuronal cell" RELATED [CALOHA:TS-1261]
synonym: "lateral ventricle neuronal cells" RELATED [CALOHA:TS-1261]
xref: CALOHA:TS-1261
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:2000029 ! central nervous system neuron
intersection_of: CL:0000540 ! neuron
intersection_of: RO:0002100 UBERON:0002285 ! has soma location telencephalic ventricle
@@ -31742,7 +31578,6 @@ def: "Neuron of the cerebellum." [NPX:PDR]
synonym: "cerebellum neuron" RELATED [CALOHA:TS-2359]
xref: CALOHA:TS-2359
xref: FMA:84665
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:2000029 ! central nervous system neuron
intersection_of: CL:0000540 ! neuron
intersection_of: RO:0002100 UBERON:0002037 ! has soma location cerebellum
@@ -32012,7 +31847,6 @@ creation_date: 2014-06-25T00:23:36Z
id: CL:2000024
name: spinal cord medial motor column neuron
def: "Any neuron that is part of a spinal cord medial motor column." [GOC:TermGenie]
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:2000029 ! central nervous system neuron
intersection_of: CL:0000540 ! neuron
intersection_of: RO:0002100 UBERON:0004059 ! has soma location spinal cord medial motor column
@@ -32088,7 +31922,6 @@ creation_date: 2014-06-25T01:17:50Z
id: CL:2000031
name: lateral line ganglion neuron
def: "Any neuron that is part of a lateral line ganglion." [GOC:TermGenie]
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:0000540 ! neuron
intersection_of: CL:0000540 ! neuron
intersection_of: RO:0002100 UBERON:2000120 ! has soma location lateral line ganglion
@@ -32275,7 +32108,6 @@ creation_date: 2014-08-12T20:50:28Z
id: CL:2000047
name: brainstem motor neuron
def: "Any motor neuron that is part of a brainstem." [GOC:TermGenie]
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:0000100 ! motor neuron
is_a: CL:2000029 ! central nervous system neuron
intersection_of: CL:0000100 ! motor neuron
@@ -32786,14 +32618,16 @@ creation_date: 2014-12-24T00:37:30Z
[Term]
id: CL:2000089
-name: dentate gyrus of hippocampal formation granule cell
-def: "The principal cell type of the dentate gyrus." [GOC:TermGenie]
-comment: The granule cell has a characteristic cone-shaped tree of spiny apical dendrites.
+name: dentate gyrus granule cell
+def: "A granule cell that has soma location in the dentate gyrus cell layer of the hippocampal formation and has an elliptical cell body and characteristic cone-shaped tree of spiny apical dendrites. The branches extend throughout the molecular layer and the distal tips of the dendritic tree end just at the hippocampal fissure or at the ventricular surface. The dentate gyrus granule cell is the principal cell type of the dentate gyrus." [GOC:TermGenie, PMID:17765709]
+comment: As far as can be determined, all dentate granule cells appear to project to CA3 and the axon trajectory is partially correlated with the position of the parent cell body. {xref="PMID:17765709"}
+synonym: "dentate gyrus of hippocampal formation granule cell" EXACT []
is_a: CL:0001033 ! hippocampal granule cell
is_a: CL:4023062 ! dentate gyrus neuron
-intersection_of: CL:0000120 ! granule cell
-intersection_of: RO:0002100 UBERON:0001885 ! has soma location dentate gyrus of hippocampal formation
+intersection_of: CL:0001033 ! hippocampal granule cell
+intersection_of: RO:0002100 UBERON:0005381 ! has soma location dentate gyrus granule cell layer
relationship: dc-contributor https://www.wikidata.org/entity/Q35563349
+relationship: RO:0002100 UBERON:0005381 ! has soma location dentate gyrus granule cell layer
creation_date: 2015-02-23T05:48:23Z
[Term]
@@ -32882,7 +32716,6 @@ creation_date: 2015-08-11T16:28:16Z
id: CL:2000097
name: midbrain dopaminergic neuron
def: "Any dopaminergic neuron that is part of a midbrain." [GOC:TermGenie]
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:0000700 ! dopaminergic neuron
is_a: CL:2000029 ! central nervous system neuron
intersection_of: CL:0000700 ! dopaminergic neuron
@@ -33037,6 +32870,7 @@ relationship: dc-contributor https://orcid.org/0000-0001-7258-9596
relationship: in_taxon NCBITaxon:10090 ! Mus musculus
relationship: RO:0002100 UBERON:8440000 ! has soma location cortical layer II/III
relationship: RO:0002292 PR:P32648 ! expresses VIP peptides (mouse)
+property_value: IAO:0000028 "L2/3 bipolar vip interneuron (Mus)" xsd:string
[Term]
id: CL:4023008
@@ -33054,6 +32888,7 @@ intersection_of: RO:0002100 UBERON:0000956 ! has soma location cerebral cortex
relationship: bearer_of PATO:0070034 ! intratelencephalic projecting
relationship: dc-contributor https://orcid.org/0000-0001-7258-9596
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
+property_value: IAO:0000028 "IT glut" xsd:string
[Term]
id: CL:4023009
@@ -33071,6 +32906,7 @@ intersection_of: RO:0002100 UBERON:0000956 ! has soma location cerebral cortex
relationship: bearer_of PATO:0070028 ! extratelencephalic projecting
relationship: dc-contributor https://orcid.org/0000-0001-7258-9596
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
+property_value: IAO:0000028 "ET glut" xsd:string
[Term]
id: CL:4023010
@@ -33083,6 +32919,7 @@ is_a: CL:0010011 ! cerebral cortex GABAergic interneuron
relationship: dc-contributor https://orcid.org/0000-0001-7258-9596
relationship: in_taxon NCBITaxon:10090 ! Mus musculus
relationship: RO:0002292 PR:000005460 ! expresses neuronal acetylcholine receptor subunit alpha-7
+property_value: IAO:0000028 "A7 interneuron" xsd:string
[Term]
id: CL:4023011
@@ -33097,6 +32934,7 @@ intersection_of: RO:0002100 UBERON:0000956 ! has soma location cerebral cortex
intersection_of: RO:0002292 PR:000032148 ! expresses lysosome-associated membrane glycoprotein 5
relationship: dc-contributor https://orcid.org/0000-0001-7258-9596
relationship: RO:0002292 PR:000032148 ! expresses lysosome-associated membrane glycoprotein 5
+property_value: IAO:0000028 "Lamp5 cortical interneuron" xsd:string
[Term]
id: CL:4023012
@@ -33114,6 +32952,7 @@ intersection_of: RO:0002100 UBERON:0000956 ! has soma location cerebral cortex
relationship: bearer_of PATO:0070030 ! near projecting
relationship: dc-contributor https://orcid.org/0000-0001-7258-9596
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
+property_value: IAO:0000028 "NP glut neuron" xsd:string
[Term]
id: CL:4023013
@@ -33128,6 +32967,7 @@ intersection_of: bearer_of PATO:0070029 ! corticothalamic projecting
intersection_of: RO:0002100 UBERON:0000956 ! has soma location cerebral cortex
relationship: bearer_of PATO:0070029 ! corticothalamic projecting
relationship: dc-contributor https://orcid.org/0000-0001-7258-9596
+property_value: IAO:0000028 "CT glut" xsd:string
[Term]
id: CL:4023014
@@ -33140,6 +32980,7 @@ relationship: dc-contributor https://orcid.org/0000-0001-7258-9596
relationship: in_taxon NCBITaxon:10090 ! Mus musculus
relationship: RO:0002100 UBERON:0005394 ! has soma location cortical layer V
relationship: RO:0002292 PR:P32648 ! expresses VIP peptides (mouse)
+property_value: IAO:0000028 "L5 vip interneuron (Mus)" xsd:string
[Term]
id: CL:4023015
@@ -33154,6 +32995,7 @@ intersection_of: RO:0002100 UBERON:0000956 ! has soma location cerebral cortex
intersection_of: RO:0002292 PR:000015325 ! expresses gamma-synuclein
relationship: dc-contributor https://orcid.org/0000-0001-7258-9596
relationship: RO:0002292 PR:000015325 ! expresses gamma-synuclein
+property_value: IAO:0000028 "sncg cortical interneuron" xsd:string
[Term]
id: CL:4023016
@@ -33168,6 +33010,7 @@ intersection_of: RO:0002100 UBERON:0000956 ! has soma location cerebral cortex
intersection_of: RO:0002292 PR:000017299 ! expresses VIP peptides
relationship: dc-contributor https://orcid.org/0000-0001-7258-9596
relationship: RO:0002292 PR:000017299 ! expresses VIP peptides
+property_value: IAO:0000028 "vip cortical interneuron" xsd:string
[Term]
id: CL:4023017
@@ -33182,6 +33025,7 @@ intersection_of: RO:0002100 UBERON:0000956 ! has soma location cerebral cortex
intersection_of: RO:0002292 PR:000015665 ! expresses somatostatin
relationship: dc-contributor https://orcid.org/0000-0001-7258-9596
relationship: RO:0002292 PR:000015665 ! expresses somatostatin
+property_value: IAO:0000028 "sst cortical interneuron" xsd:string
[Term]
id: CL:4023018
@@ -33196,6 +33040,7 @@ intersection_of: RO:0002100 UBERON:0000956 ! has soma location cerebral cortex
intersection_of: RO:0002292 PR:000013502 ! expresses parvalbumin alpha
relationship: dc-contributor https://orcid.org/0000-0001-7258-9596
relationship: RO:0002292 PR:000013502 ! expresses parvalbumin alpha
+property_value: IAO:0000028 "pvalb cortical interneuron" xsd:string
[Term]
id: CL:4023019
@@ -33235,6 +33080,7 @@ is_a: CL:4023011 ! lamp5 GABAergic cortical interneuron
relationship: dc-contributor https://orcid.org/0000-0001-7258-9596
relationship: in_taxon NCBITaxon:10090 ! Mus musculus
relationship: RO:0002292 PR:Q9D387 ! expresses lysosome-associated membrane glycoprotein 5 (mouse)
+property_value: IAO:0000028 "canopy lamp5 interneuron" xsd:string
[Term]
id: CL:4023023
@@ -33247,6 +33093,7 @@ is_a: CL:4023011 ! lamp5 GABAergic cortical interneuron
relationship: dc-contributor https://orcid.org/0000-0001-7258-9596
relationship: in_taxon NCBITaxon:10090 ! Mus musculus
relationship: RO:0002292 PR:Q9D387 ! expresses lysosome-associated membrane glycoprotein 5 (mouse)
+property_value: IAO:0000028 "L5,6 NGC Lamp5 interneuron (Mus)" xsd:string
[Term]
id: CL:4023024
@@ -33259,6 +33106,7 @@ is_a: CL:4023011 ! lamp5 GABAergic cortical interneuron
relationship: dc-contributor https://orcid.org/0000-0001-7258-9596
relationship: in_taxon NCBITaxon:10090 ! Mus musculus
relationship: RO:0002292 PR:Q9D387 ! expresses lysosome-associated membrane glycoprotein 5 (mouse)
+property_value: IAO:0000028 "NGC Lamp5 interneuron (Mus)" xsd:string
[Term]
id: CL:4023025
@@ -33294,6 +33142,7 @@ relationship: dc-contributor https://orcid.org/0000-0001-7258-9596
relationship: in_taxon NCBITaxon:10090 ! Mus musculus
relationship: RO:0002100 UBERON:0005394 ! has soma location cortical layer V
relationship: RO:0002292 PR:P60041 ! expresses somatostatin (mouse)
+property_value: IAO:0000028 "L5 T Martinotti sst interneuron (Mus)" xsd:string
[Term]
id: CL:4023028
@@ -33306,6 +33155,7 @@ relationship: dc-contributor https://orcid.org/0000-0001-7258-9596
relationship: in_taxon NCBITaxon:10090 ! Mus musculus
relationship: RO:0002100 UBERON:0005394 ! has soma location cortical layer V
relationship: RO:0002292 PR:P60041 ! expresses somatostatin (mouse)
+property_value: IAO:0000028 "L5 non-Martinotti sst interneuron (Mus)" xsd:string
[Term]
id: CL:4023029
@@ -33330,6 +33180,7 @@ is_a: CL:4023087 ! fan Martinotti neuron
relationship: dc-contributor https://orcid.org/0000-0001-7258-9596
relationship: in_taxon NCBITaxon:10090 ! Mus musculus
relationship: RO:0002292 PR:P60041 ! expresses somatostatin (mouse)
+property_value: IAO:0000028 "L2/3/5 fan Martinotti sst interneuron (Mus)" xsd:string
[Term]
id: CL:4023031
@@ -33343,6 +33194,7 @@ relationship: dc-contributor https://orcid.org/0000-0001-7258-9596
relationship: in_taxon NCBITaxon:10090 ! Mus musculus
relationship: RO:0002100 UBERON:0005393 ! has soma location cortical layer IV
relationship: RO:0002292 PR:P60041 ! expresses somatostatin (mouse)
+property_value: IAO:0000028 "L4 sst interneuron (Mus)" xsd:string
[Term]
id: CL:4023032
@@ -33379,6 +33231,7 @@ xref: ILX:0107356
is_a: CL:4023018 ! pvalb GABAergic cortical interneuron
is_a: CL:4023083 ! chandelier cell
relationship: dc-contributor https://orcid.org/0000-0001-7258-9596
+property_value: IAO:0000028 "chandelier PV interneuron" xsd:string
[Term]
id: CL:4023038
@@ -33392,13 +33245,13 @@ intersection_of: CL:0000679 ! glutamatergic neuron
intersection_of: RO:0002100 UBERON:8440003 ! has soma location cortical layer VIb
relationship: dc-contributor https://orcid.org/0000-0001-7258-9596
relationship: RO:0002100 UBERON:8440003 ! has soma location cortical layer VIb
+property_value: IAO:0000028 "L6b glut" xsd:string
[Term]
id: CL:4023039
name: amygdala excitatory neuron
comment: An excitatory neuron that is located in the amygdala. {xref="DOI:10.1101/2022.10.12.511898"}
subset: human_reference_atlas
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:0000679 ! glutamatergic neuron
is_a: CL:2000029 ! central nervous system neuron
intersection_of: CL:0000540 ! neuron
@@ -33416,6 +33269,7 @@ subset: BDS_subset
synonym: "L2/3-6 IT projecting neuron" EXACT []
is_a: CL:4023008 ! intratelencephalic-projecting glutamatergic cortical neuron
relationship: dc-contributor https://orcid.org/0000-0001-7258-9596
+property_value: IAO:0000028 "L2/3-6 IT glut" xsd:string
[Term]
id: CL:4023041
@@ -33434,6 +33288,7 @@ intersection_of: CL:4023009 ! extratelencephalic-projecting glutamatergic cortic
intersection_of: RO:0002100 UBERON:0005394 ! has soma location cortical layer V
relationship: dc-contributor https://orcid.org/0000-0001-7258-9596
relationship: RO:0002100 UBERON:0005394 ! has soma location cortical layer V
+property_value: IAO:0000028 "L5 ET glut" xsd:string
[Term]
id: CL:4023042
@@ -33447,6 +33302,7 @@ intersection_of: RO:0002100 UBERON:0005395 ! has soma location cortical layer VI
relationship: dc-contributor https://orcid.org/0000-0001-7258-9596
relationship: RO:0002100 UBERON:0005395 ! has soma location cortical layer VI
relationship: RO:0013001 UBERON:0010225 ! has synaptic IO in region thalamic complex
+property_value: IAO:0000028 "L6 CT glut" xsd:string
[Term]
id: CL:4023043
@@ -33463,6 +33319,7 @@ intersection_of: RO:0002100 UBERON:8440002 ! has soma location cortical layer V/
relationship: dc-contributor https://orcid.org/0000-0001-7258-9596
relationship: RO:0002100 UBERON:0001384 ! has soma location primary motor cortex
relationship: RO:0002100 UBERON:8440002 ! has soma location cortical layer V/VI
+property_value: IAO:0000028 "L5/6 NP glut MOp" xsd:string
[Term]
id: CL:4023044
@@ -33474,6 +33331,7 @@ synonym: "non-MY ET MOp (Mus)" EXACT []
is_a: CL:2000049 ! primary motor cortex pyramidal cell
is_a: CL:4023041 ! L5 extratelencephalic projecting glutamatergic cortical neuron
relationship: dc-contributor https://orcid.org/0000-0001-7258-9596
+property_value: IAO:0000028 "non-MY ET glut MOp" xsd:string
[Term]
id: CL:4023045
@@ -33488,6 +33346,7 @@ is_a: CL:4023041 ! L5 extratelencephalic projecting glutamatergic cortical neuro
relationship: bearer_of PATO:0070031 ! corticomedulla projecting
relationship: dc-contributor https://orcid.org/0000-0001-7258-9596
relationship: RO:0013001 UBERON:0001896 ! has synaptic IO in region medulla oblongata
+property_value: IAO:0000028 "MY ET glut MOp" xsd:string
[Term]
id: CL:4023046
@@ -33497,6 +33356,7 @@ subset: BDS_subset
is_a: CL:4023038 ! L6b glutamatergic cortical neuron
relationship: dc-contributor https://orcid.org/0000-0001-7258-9596
relationship: RO:0002100 UBERON:0001384 ! has soma location primary motor cortex
+property_value: IAO:0000028 "L6b subplate glut" xsd:string
[Term]
id: CL:4023047
@@ -33512,6 +33372,7 @@ intersection_of: RO:0002100 UBERON:8440000 ! has soma location cortical layer II
relationship: dc-contributor https://orcid.org/0000-0001-7258-9596
relationship: RO:0002100 UBERON:0001384 ! has soma location primary motor cortex
relationship: RO:0002100 UBERON:8440000 ! has soma location cortical layer II/III
+property_value: IAO:0000028 "L2/3 IT glut MOp" xsd:string
[Term]
id: CL:4023048
@@ -33528,6 +33389,7 @@ intersection_of: RO:0002100 UBERON:8440001 ! has soma location cortical layer IV
relationship: dc-contributor https://orcid.org/0000-0001-7258-9596
relationship: RO:0002100 UBERON:0001384 ! has soma location primary motor cortex
relationship: RO:0002100 UBERON:8440001 ! has soma location cortical layer IV/V
+property_value: IAO:0000028 "L4/5 IT glut MOp" xsd:string
[Term]
id: CL:4023049
@@ -33544,6 +33406,7 @@ intersection_of: RO:0002100 UBERON:0005394 ! has soma location cortical layer V
relationship: dc-contributor https://orcid.org/0000-0001-7258-9596
relationship: RO:0002100 UBERON:0001384 ! has soma location primary motor cortex
relationship: RO:0002100 UBERON:0005394 ! has soma location cortical layer V
+property_value: IAO:0000028 "L5 IT glut MOp" xsd:string
[Term]
id: CL:4023050
@@ -33561,6 +33424,7 @@ intersection_of: RO:0002100 UBERON:0005395 ! has soma location cortical layer VI
relationship: bearer_of PATO:0070019 ! untufted pyramidal morphology
relationship: dc-contributor https://orcid.org/0000-0001-7258-9596
relationship: RO:0002100 UBERON:0005395 ! has soma location cortical layer VI
+property_value: IAO:0000028 "L6 IT glut MOp" xsd:string
[Term]
id: CL:4023051
@@ -33611,6 +33475,7 @@ is_a: CL:2000049 ! primary motor cortex pyramidal cell
is_a: CL:4023042 ! L6 corticothalamic-projecting glutamatergic cortical neuron
relationship: bearer_of PATO:0070019 ! untufted pyramidal morphology
relationship: dc-contributor https://orcid.org/0000-0001-7258-9596
+property_value: IAO:0000028 "CT VAL/VM glut MOp" xsd:string
[Term]
id: CL:4023056
@@ -33701,13 +33566,13 @@ name: medial ganglionic eminence derived interneuron
def: "An interneuron that is derived from the medial ganglionic eminence." [DOI:10.1101/2022.10.12.511898]
subset: human_reference_atlas
synonym: "MGE interneuron" EXACT []
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:0000099 ! interneuron
intersection_of: CL:0000099 ! interneuron
intersection_of: develops_from UBERON:0004024 ! medial ganglionic eminence
relationship: dc-contributor http://orcid.org/0000-0001-7258-9596
relationship: develops_from UBERON:0004024 ! medial ganglionic eminence
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
+property_value: IAO:0000028 "MGE interneuron" xsd:string
[Term]
id: CL:4023064
@@ -33715,13 +33580,13 @@ name: caudal ganglionic eminence derived interneuron
def: "An interneuron that is derived from the caudal ganglionic eminence." [DOI:10.1101/2022.10.12.511898]
subset: human_reference_atlas
synonym: "CGE interneuron" EXACT []
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:0000099 ! interneuron
intersection_of: CL:0000099 ! interneuron
intersection_of: develops_from UBERON:0004026 ! caudal ganglionic eminence
relationship: dc-contributor http://orcid.org/0000-0001-7258-9596
relationship: develops_from UBERON:0004026 ! caudal ganglionic eminence
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
+property_value: IAO:0000028 "CGE interneuron" xsd:string
[Term]
id: CL:4023065
@@ -33732,6 +33597,7 @@ is_a: CL:0000617 ! GABAergic neuron
is_a: CL:0010012 ! cerebral cortex neuron
relationship: dc-contributor https://orcid.org/0000-0001-7258-9596
relationship: RO:0002292 PR:000010317 ! expresses homeobox protein Meis2
+property_value: IAO:0000028 "meis2 GABA" xsd:string
[Term]
id: CL:4023066
@@ -33760,7 +33626,6 @@ id: CL:4023068
name: thalamic excitatory neuron
def: "An excitatory neuron that has its soma located in the thalamic complex." [DOI:10.1101/2022.10.12.511898]
subset: human_reference_atlas
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:0000679 ! glutamatergic neuron
is_a: CL:2000029 ! central nervous system neuron
intersection_of: CL:0000540 ! neuron
@@ -33782,6 +33647,7 @@ intersection_of: capable_of GO:0061534 ! gamma-aminobutyric acid secretion, neur
intersection_of: develops_from UBERON:0004024 ! medial ganglionic eminence
intersection_of: RO:0002100 UBERON:0000956 ! has soma location cerebral cortex
relationship: dc-contributor https://orcid.org/0000-0001-7258-9596
+property_value: IAO:0000028 "MGE cortical gaba interneuron" xsd:string
[Term]
id: CL:4023070
@@ -33795,6 +33661,7 @@ intersection_of: capable_of GO:0061534 ! gamma-aminobutyric acid secretion, neur
intersection_of: develops_from UBERON:0004026 ! caudal ganglionic eminence
intersection_of: RO:0002100 UBERON:0000956 ! has soma location cerebral cortex
relationship: dc-contributor https://orcid.org/0000-0001-7258-9596
+property_value: IAO:0000028 "CGE gaba cortical interneuron" xsd:string
[Term]
id: CL:4023071
@@ -33807,6 +33674,7 @@ relationship: dc-contributor https://orcid.org/0000-0001-7258-9596
relationship: in_taxon NCBITaxon:10090 ! Mus musculus
relationship: RO:0002100 UBERON:8440002 ! has soma location cortical layer V/VI
relationship: RO:0002292 PR:P09240 ! expresses cholecystokinin (mouse)
+property_value: IAO:0000028 "L5/6 cck interneuron (Mus)" xsd:string
[Term]
id: CL:4023072
@@ -33837,7 +33705,6 @@ id: CL:4023074
name: mammillary body neuron
def: "A neuron that has its soma located in the mammillary body." [DOI:10.1101/2022.10.12.511898]
subset: human_reference_atlas
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:2000029 ! central nervous system neuron
intersection_of: CL:0000540 ! neuron
intersection_of: RO:0002100 UBERON:0002206 ! has soma location mammillary body
@@ -33858,6 +33725,7 @@ relationship: in_taxon NCBITaxon:10090 ! Mus musculus
relationship: RO:0002100 UBERON:0005395 ! has soma location cortical layer VI
relationship: RO:0002292 PR:P24529 ! expresses tyrosine 3-monooxygenase (mouse)
relationship: RO:0002292 PR:P60041 ! expresses somatostatin (mouse)
+property_value: IAO:0000028 "L6 th sst interneuron (Mus)" xsd:string
[Term]
id: CL:4023076
@@ -33918,6 +33786,7 @@ synonym: "stellate L6 IT MOp (Mus musculus)" EXACT []
is_a: CL:4023050 ! L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex
relationship: bearer_of PATO:0070020 ! stellate pyramidal morphology
relationship: dc-contributor https://orcid.org/0000-0001-7258-9596
+property_value: IAO:0000028 "stellate L6 IT glut MOp" xsd:string
[Term]
id: CL:4023081
@@ -33928,6 +33797,7 @@ synonym: "inverted L6 IT MOp (Mus musculus)" EXACT []
is_a: CL:4023050 ! L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex
relationship: bearer_of PATO:0070021 ! inverted pyramidal morphology
relationship: dc-contributor https://orcid.org/0000-0001-7258-9596
+property_value: IAO:0000028 "inverted L6 IT glut MOp" xsd:string
[Term]
id: CL:4023083
@@ -34167,7 +34037,6 @@ id: CL:4023107
name: reticulospinal neuron
def: "A neuron with soma location in the reticular formation with axons that extend into the spinal cord such. Reticulospinal neuron activity can lead to a variety of motor behaviors." [PMID:29720934]
synonym: "RSN" EXACT [PMID:29720934]
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:2000029 ! central nervous system neuron
intersection_of: CL:0000540 ! neuron
intersection_of: RO:0002100 UBERON:0002275 ! has soma location reticular formation
@@ -34201,7 +34070,6 @@ relationship: dc-contributor https://orcid.org/0000-0001-7258-9596
id: CL:4023110
name: amygdala pyramidal neuron
def: "A pyramidal neuron with soma located in the amygdala." [PMID:1375860]
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:0000598 ! pyramidal neuron
is_a: CL:2000029 ! central nervous system neuron
intersection_of: CL:0000598 ! pyramidal neuron
@@ -34223,7 +34091,6 @@ relationship: dc-contributor https://orcid.org/0000-0001-7258-9596
id: CL:4023112
name: vestibular afferent neuron
def: "An afferent neuron of the vestibular system that innervate the base of the hair cell and increase or decrease their neural firing rate as the receptor cell is excited or inhibited." [PMID:2585041]
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:0000101 ! sensory neuron
relationship: dc-contributor https://orcid.org/0000-0001-7258-9596
relationship: RO:0002120 CL:0000609 ! synapsed to vestibular hair cell
@@ -34252,8 +34119,8 @@ name: type 1 spiral ganglion neuron
def: "A spiral ganglion neuron that innervates inner hair cells. Type 1 spiral ganglion neurons are myelinated and bipolar." [WikipediaVersioned:Spiral_ganglion&oldid=994446209]
comment: Type 1 spiral ganglion neurons comprise the vast majority of spiral ganglion cells. {xref="WikipediaVersioned:Spiral_ganglion&oldid=994446209"}
synonym: "type I spiral ganglion cell" EXACT []
-is_a: CARO:0001001 ! neuron projection bundle
is_a: CL:0011113 ! spiral ganglion neuron
+is_a: UBERON:0000122 ! neuron projection bundle
intersection_of: CL:0011113 ! spiral ganglion neuron
intersection_of: innervates CL:0000589 ! cochlear inner hair cell
relationship: bearer_of PATO:0070006 ! cortical bipolar morphology
@@ -34266,8 +34133,8 @@ name: type 2 spiral ganglion neuron
def: "A spiral ganglion neuron that innervates outer hair cells. Type 1 spiral ganglion neurons are unmyelinated and unipolar." [WikipediaVersioned:Spiral_ganglion&oldid=994446209]
comment: Outer hair cells form reciprocal synapses onto type 2 spiral ganglion cells, suggesting that the type 2 cells have both afferent and efferent roles. {xref="WikipediaVersioned:Spiral_ganglion&oldid=994446209"}
synonym: "type II spiral ganglion cell" EXACT []
-is_a: CARO:0001001 ! neuron projection bundle
is_a: CL:0011113 ! spiral ganglion neuron
+is_a: UBERON:0000122 ! neuron projection bundle
intersection_of: CL:0011113 ! spiral ganglion neuron
intersection_of: innervates CL:0000601 ! cochlear outer hair cell
relationship: bearer_of PATO:0070025 ! unipolar neuron morphology
@@ -34287,6 +34154,7 @@ relationship: dc-contributor https://orcid.org/0000-0001-7258-9596
relationship: in_taxon NCBITaxon:10090 ! Mus musculus
relationship: RO:0002100 UBERON:8440002 ! has soma location cortical layer V/VI
relationship: RO:0002292 PR:P60041 ! expresses somatostatin (mouse)
+property_value: IAO:0000028 "L5/6 non-Martinotti sst interneuron (Mus)" xsd:string
[Term]
id: CL:4023119
@@ -34320,6 +34188,7 @@ synonym: "long-range GABAergic interneuron" BROAD []
is_a: CL:4023017 ! sst GABAergic cortical interneuron
relationship: dc-contributor https://orcid.org/0000-0001-7258-9596
relationship: RO:0002292 PR:000005444 ! expresses chondrolectin
+property_value: IAO:0000028 "sst chodl cortical interneuron" xsd:string
[Term]
id: CL:4023122
@@ -34336,7 +34205,6 @@ relationship: RO:0002292 PR:000001635 ! expresses oxytocin receptor
id: CL:4023123
name: hypothalamus kisspeptin neuron
def: "A kisspeptin neuron that is located in the hypothalamus. These neurons project to and activate gonadotrophin-releasing hormone neurons (acting via the kisspeptin receptor) in the hypothalamus and stimulate the secretion of gonadotrophin-releasing hormone." [PMID:30042117]
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:2000029 ! central nervous system neuron
is_a: CL:4023130 ! kisspeptin neuron
intersection_of: CL:4023130 ! kisspeptin neuron
@@ -34434,7 +34302,6 @@ id: CL:4023158
name: octopus cell of the mammalian cochlear nucleus
def: "A neuron in the posterior ventral cochlear nucleus that is distinguished by their long, thick and tentacle-shaped dendrites that typically emanate from one side of the cell body." [WikipediaVersioned:title=Cochlear_nucleus&oldid=1090176664]
comment: Octopus cells respond only at the onset of a broad-band simple tonal stimulus and form a pathway to the superior paraolivary nucleus and to the ventral nucleus of the lateral lemniscus. {xref="WikipediaVersioned:title=Cochlear_nucleus&oldid=1090176664", xref="PMID:11976365"}
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:2000029 ! central nervous system neuron
relationship: dc-contributor http://orcid.org/0000-0001-7258-9596
relationship: RO:0002100 UBERON:0002831 ! has soma location posteroventral cochlear nucleus
@@ -34457,7 +34324,6 @@ name: cartwheel cell
def: "A neuron of the dorsal cochlear nucleus with spiny dendrites that receive input from the axons of granule cells and with axons that release GABA and glycine onto cartwheel, pyramidal and giant cell targets." [ILX:0102311, WikipediaVersioned:Cartwheel_cell&oldid=1040398094]
comment: Cartwheel cells share many of the features, molecular and electrophysiological, of cerebellar Purkinje neurons. {xref="ILX:0102311"}
xref: ILX:0102311
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:0000617 ! GABAergic neuron
is_a: CL:1001509 ! glycinergic neuron
is_a: CL:2000029 ! central nervous system neuron
@@ -34469,7 +34335,6 @@ relationship: synapsed_by CL:0000120 ! granule cell
id: CL:4023161
name: unipolar brush cell
def: "An excitatory glutamatergic interneuron found in the granular layer of the cerebellar cortex and also in the granule cell domain of the cochlear nucleus. Unipolar brush cells have a round or oval cell body with usually a single short dendrite that ends in a brush-like tuft of short dendrites unique to them known as dendrioles." [PMID:9193142, WikipediaVersioned:Unipolar_brush_cell&oldid=1045937026]
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:0000402 ! CNS interneuron
is_a: CL:0000679 ! glutamatergic neuron
relationship: bearer_of PATO:0070025 ! unipolar neuron morphology
@@ -34480,7 +34345,6 @@ relationship: RO:0002100 UBERON:0002028 ! has soma location hindbrain
id: CL:4023162
name: bushy cell
def: "A neuron found in the anterior part of the ventral cochlear nucleus that has the appearance of bushes, having short dendrites. Bushy cells give outputs to different parts of the superior olivary complex." [WikipediaVersioned:Bushy_cell&oldid=879061753]
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:2000029 ! central nervous system neuron
relationship: dc-contributor http://orcid.org/0000-0001-7258-9596
relationship: RO:0002100 UBERON:0002830 ! has soma location anteroventral cochlear nucleus
@@ -34557,7 +34421,6 @@ def: "A neuron with a small cell body that is located in a koniocellular layer o
comment: In adult monkeys, koniocellular cells can be distinguished from parvocellular and magnocellular of the LGN by their expression of calbindin, the alpha subunit of type II calmodulin-dependent protein kinase, and the gamma subunit of protein kinase C. {xref="PMID:10845061"}
synonym: "K cell" EXACT [PMID:10845061]
xref: NIFEXT:44
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:2000029 ! central nervous system neuron
intersection_of: CL:0000540 ! neuron
intersection_of: RO:0002100 UBERON:0013615 ! has soma location koniocellular layer of dorsal nucleus of lateral geniculate body
@@ -34600,6 +34463,7 @@ is_a: CL:2000016 ! lung microvascular endothelial cell
intersection_of: CL:0002144 ! capillary endothelial cell
intersection_of: part_of UBERON:0002048 ! lung
relationship: dc-contributor https://orcid.org/0000-0002-3293-5463
+relationship: part_of UBERON:0016405 ! pulmonary capillary
creation_date: 2021-11-23T02:31:40Z
[Term]
@@ -35349,7 +35213,7 @@ id: CL:4030055
name: intermediate cell of urothelium
def: "A urothelial cell that is part of the regenerative layer(s) of cells directly superficial to basal cells in urothelium. The layer of intermediate cells in the urothelium ranges from one to several layers thick depending on the species with intermediate cells attached to adjacent cell layers and one another via desmosomes." [doi:10.1038/s41385-022-00565-0]
comment: It has been noted in at least some mammalian species that the urothelial intermediate cell type is similar to basal cells by expressing CK17 and (unlike umbrella cells) p63 but is positive for uroplakins (UPK) and negative for CK5. Urothelial intermediate cells have also been noted to be larger in diameter than urothelial basal cells. {xref="doi:10.1038/s41385-022-00565-0"}
-synonym: "
urothelial intermediate cell" EXACT [doi:10.1007/978-3-030-14366-4_8]
+synonym: "urothelial intermediate cell" EXACT [doi:10.1007/978-3-030-14366-4_8]
xref: FMA:84155
is_a: CL:0000731 ! urothelial cell
property_value: dc-contributor "https://orcid.org/0000-0003-3065-9183" xsd:string
@@ -35367,6 +35231,18 @@ is_a: CL:0000731 ! urothelial cell
property_value: dc-contributor "https://orcid.org/0000-0003-3065-9183" xsd:string
property_value: dcterms-date "2023-06-16T07:59:43Z" xsd:dateTime
+[Term]
+id: CL:4030057
+name: eccentric medium spiny neuron
+def: "A medium spiny neuron that exhibits transcriptional divergence from direct and indirect spiny projection neurons, for example, enrichment in Casz1, Otof, Cacng5 and Pcdh8 noted in mice. Whilst in general medium spiny neurons have been found to be differentially distributed across the basal ganglia, the eccentric medium spiny neuron cell type has been found to be more evenly distributed throughout cerebral nuclei." [doi:10.1016/j.cell.2018.07.028, doi:10.1101/2022.10.12.511898]
+comment: The term “eccentric” is used in the name eccentric medium spiny neuron (MSN) due to the exhibited transcriptional divergence from canonical spiny projection neurons. It has been noted in at least one study that an eccentric MSN differs in expression from direct and indirect MSNs by 110 genes (more than the 68 that distinguished direct and indirect spiny projection neurons from each other) and expresses many genes that have little expression in the rest of the striatum. It also has been noted in at least one human study that most eccentric MSNs expressed only DRD1, but many in the basal ganglia co-expressed DRD1 and DRD2, suggesting regional specialization of a more broadly distributed cell type. {xref="doi:10.1101/2022.10.12.511898", xref="doi:10.1016/j.cell.2018.07.028"}
+synonym: "eccentric MSN" RELATED abbreviation [doi:10.1101/2022.10.12.511898]
+synonym: "eccentric spiny projection neuron" EXACT [doi:10.1016/j.cell.2018.07.028]
+synonym: "eccentric SPN" RELATED abbreviation [doi:10.1016/j.cell.2018.07.028]
+synonym: "eSPN" RELATED abbreviation [doi:10.1016/j.cell.2018.07.028]
+is_a: CL:1001474 ! medium spiny neuron
+property_value: dcterms-date "2023-06-23T14:59:36Z" xsd:dateTime
+
[Term]
id: CL:4032000
name: club-like cell of the urethral epithelium
@@ -35610,7 +35486,7 @@ intersection_of: CL:0000192 ! smooth muscle cell
intersection_of: part_of UBERON:0002186 ! bronchiole
relationship: dc-contributor https://orcid.org/0000-0001-6677-8489
relationship: dc-contributor https://orcid.org/0000-0002-9185-3994
-relationship: part_of UBERON:0002186 ! bronchiole
+relationship: part_of UBERON:0004515 ! smooth muscle tissue of bronchiole
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: dcterms-date "2023-03-16T09:38:17Z" xsd:dateTime
@@ -35620,9 +35496,16 @@ name: lung megakaryocyte
def: "A megakaryocyte that is resident in the lung connective tissue." [PMID:33351116]
subset: human_reference_atlas
synonym: "lung MKs" RELATED PLURAL [PMID:33351116]
+synonym: "lung resident megakaryocyte" EXACT [PMID:36524131]
+synonym: "lung-resident megakaryocyte" EXACT [PMID:36524131]
+synonym: "MKL" RELATED abbreviation [PMID:36524131]
is_a: CL:0000556 ! megakaryocyte
+is_a: CL:0002320 ! connective tissue cell
+intersection_of: CL:0000556 ! megakaryocyte
+intersection_of: part_of UBERON:0000114 ! lung connective tissue
relationship: dc-contributor https://orcid.org/0000-0001-6677-8489
relationship: dc-contributor https://orcid.org/0000-0002-9185-3994
+relationship: part_of UBERON:0000114 ! lung connective tissue
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: dcterms-date "2023-03-16T11:31:23Z" xsd:dateTime
@@ -60188,6 +60071,16 @@ intersection_of: GO:0048856 ! anatomical structure development
intersection_of: results_in_development_of UBERON:0001650 ! hypoglossal nerve
relationship: results_in_development_of UBERON:0001650 ! hypoglossal nerve
+[Term]
+id: GO:0021567
+name: rhombomere 1 development
+namespace: biological_process
+def: "The process whose specific outcome is the progression of rhombomere 1 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]
+is_a: GO:0021546 ! rhombomere development
+intersection_of: GO:0048856 ! anatomical structure development
+intersection_of: results_in_development_of UBERON:0005499 ! rhombomere 1
+relationship: results_in_development_of UBERON:0005499 ! rhombomere 1
+
[Term]
id: GO:0021575
name: hindbrain morphogenesis
@@ -60762,6 +60655,28 @@ intersection_of: results_in_formation_of UBERON:0001648 ! vestibulocochlear nerv
relationship: part_of GO:0021648 ! vestibulocochlear nerve morphogenesis
relationship: results_in_formation_of UBERON:0001648 ! vestibulocochlear nerve
+[Term]
+id: GO:0021651
+name: rhombomere 1 morphogenesis
+namespace: biological_process
+def: "The process in which the anatomical structure of rhombomere 1 is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]
+is_a: GO:0021593 ! rhombomere morphogenesis
+intersection_of: GO:0009653 ! anatomical structure morphogenesis
+intersection_of: results_in_morphogenesis_of UBERON:0005499 ! rhombomere 1
+relationship: part_of GO:0021567 ! rhombomere 1 development
+relationship: results_in_morphogenesis_of UBERON:0005499 ! rhombomere 1
+
+[Term]
+id: GO:0021652
+name: rhombomere 1 formation
+namespace: biological_process
+def: "The process that gives rise to rhombomere 1. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid]
+is_a: GO:0021594 ! rhombomere formation
+intersection_of: GO:0048646 ! anatomical structure formation involved in morphogenesis
+intersection_of: results_in_formation_of UBERON:0005499 ! rhombomere 1
+relationship: part_of GO:0021651 ! rhombomere 1 morphogenesis
+relationship: results_in_formation_of UBERON:0005499 ! rhombomere 1
+
[Term]
id: GO:0021654
name: rhombomere boundary formation
@@ -61083,6 +60998,7 @@ namespace: biological_process
def: "The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar granule cell. Differentiation includes the processes involved in commitment of a neuroblast to a granule cell fate. A granule cell is a glutamatergic interneuron found in the cerebellar cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725]
is_a: GO:0021533 ! cell differentiation in hindbrain
is_a: GO:0021953 ! central nervous system neuron differentiation
+is_a: GO:1905962 ! glutamatergic neuron differentiation
intersection_of: GO:0030154 ! cell differentiation
intersection_of: results_in_acquisition_of_features_of CL:0001031 ! cerebellar granule cell
relationship: part_of GO:0021684 ! cerebellar granular layer formation
@@ -140480,6 +140396,95 @@ relationship: positively_regulates GO:0005261 ! monoatomic cation channel activi
created_by: vk
creation_date: 2011-12-07T07:14:57Z
+[Term]
+id: IAO:0000027
+name: data item
+def: "An information content entity that is intended to be a truthful statement about something (modulo, e.g., measurement precision or other systematic errors) and is constructed/acquired by a method which reliably tends to produce (approximately) truthful statements." []
+is_a: IAO:0000030 ! information content entity
+property_value: editor_note "2/2/2009 Alan and Bjoern discussing FACS run output data. This is a data item because it is about the cell population. Each element records an event and is typically further composed a set of measurment data items that record the fluorescent intensity stimulated by one of the lasers." xsd:string
+property_value: editor_note "2009-03-16: data item deliberatly ambiguous: we merged data set and datum to be one entity, not knowing how to define singular versus plural. So data item is more general than datum." xsd:string
+property_value: editor_note "2009-03-16: removed datum as alternative term as datum specifically refers to singular form, and is thus not an exact synonym." xsd:string
+property_value: editor_note "2014-03-31: See discussion at http://odontomachus.wordpress.com/2014/03/30/aboutness-objects-propositions/" xsd:string
+property_value: editor_note "JAR: datum -- well, this will be very tricky to define, but maybe some \ninformation-like stuff that might be put into a computer and that is \nmeant, by someone, to denote and/or to be interpreted by some \nprocess... I would include lists, tables, sentences... I think I might \ndefer to Barry, or to Brian Cantwell Smith\n\nJAR: A data item is an approximately justified approximately true approximate belief" xsd:string
+property_value: IAO:0000111 "data item" xsd:string
+property_value: IAO:0000112 "Data items include counts of things, analyte concentrations, and statistical summaries." xsd:string
+property_value: IAO:0000114 IAO:0000125
+property_value: IAO:0000117 "PERSON: Alan Ruttenberg" xsd:string
+property_value: IAO:0000117 "PERSON: Chris Stoeckert" xsd:string
+property_value: IAO:0000117 "PERSON: Jonathan Rees" xsd:string
+property_value: IAO:0000118 "data" xsd:string
+
+[Term]
+id: IAO:0000028
+name: symbol
+def: "An information content entity that is a mark(s) or character(s) used as a conventional representation of another entity." []
+is_a: IAO:0000030 ! information content entity
+property_value: editor_note "20091104, MC: this needs work and will most probably change" xsd:string
+property_value: editor_note "2014-03-31: We would like to have a deeper analysis of 'mark' and 'sign' in the future (see https://github.com/information-artifact-ontology/IAO/issues/154)." xsd:string
+property_value: IAO:0000111 "symbol" xsd:string
+property_value: IAO:0000112 "a serial number such as \"12324X\"" xsd:string
+property_value: IAO:0000112 "a stop sign" xsd:string
+property_value: IAO:0000112 "a written proper name such as \"OBI\"" xsd:string
+property_value: IAO:0000114 IAO:0000125
+property_value: IAO:0000117 "PERSON: James A. Overton" xsd:string
+property_value: IAO:0000117 "PERSON: Jonathan Rees" xsd:string
+property_value: IAO:0000119 "based on Oxford English Dictionary" xsd:string
+
+[Term]
+id: IAO:0000030
+name: information content entity
+def: "A generically dependent continuant that is about some thing." []
+is_a: BFO:0000031 ! generically dependent continuant
+relationship: IAO:0000136 BFO:0000001 ! is about
+property_value: editor_note "2014-03-10: The use of \"thing\" is intended to be general enough to include universals and configurations (see https://groups.google.com/d/msg/information-ontology/GBxvYZCk1oc/-L6B5fSBBTQJ)." xsd:string
+property_value: editor_note "information_content_entity 'is_encoded_in' some digital_entity in obi before split (040907). information_content_entity 'is_encoded_in' some physical_document in obi before split (040907).\n\nPrevious. An information content entity is a non-realizable information entity that 'is encoded in' some digital or physical entity." xsd:string
+property_value: IAO:0000111 "information content entity" xsd:string
+property_value: IAO:0000112 "Examples of information content entites include journal articles, data, graphical layouts, and graphs." xsd:string
+property_value: IAO:0000114 IAO:0000122
+property_value: IAO:0000117 "PERSON: Chris Stoeckert" xsd:string
+property_value: IAO:0000119 "OBI_0000142" xsd:string
+
+[Term]
+id: IAO:0000078
+name: curation status specification
+def: "The curation status of the term. The allowed values come from an enumerated list of predefined terms. See the specification of these instances for more detailed definitions of each enumerated value." []
+is_a: IAO:0000102 ! data about an ontology part
+property_value: editor_note "Better to represent curation as a process with parts and then relate labels to that process (in IAO meeting)" xsd:string
+property_value: IAO:0000111 "curation status specification" xsd:string
+property_value: IAO:0000114 IAO:0000125
+property_value: IAO:0000117 "PERSON:Bill Bug" xsd:string
+property_value: IAO:0000119 "GROUP:OBI:" xsd:string
+property_value: IAO:0000119 "OBI_0000266" xsd:string
+
+[Term]
+id: IAO:0000102
+name: data about an ontology part
+def: "Data about an ontology part is a data item about a part of an ontology, for example a term" []
+is_a: IAO:0000027 ! data item
+property_value: IAO:0000111 "data about an ontology part" xsd:string
+property_value: IAO:0000117 "Person:Alan Ruttenberg" xsd:string
+
+[Term]
+id: IAO:0000225
+name: obsolescence reason specification
+def: "The reason for which a term has been deprecated. The allowed values come from an enumerated list of predefined terms. See the specification of these instances for more detailed definitions of each enumerated value." []
+is_a: IAO:0000102 ! data about an ontology part
+property_value: editor_note "The creation of this class has been inspired in part by Werner Ceusters' paper, Applying evolutionary terminology auditing to the Gene Ontology." xsd:string
+property_value: IAO:0000111 "obsolescence reason specification" xsd:string
+property_value: IAO:0000114 IAO:0000125
+property_value: IAO:0000117 "PERSON: Alan Ruttenberg" xsd:string
+property_value: IAO:0000117 "PERSON: Melanie Courtot" xsd:string
+
+[Term]
+id: IAO:0000409
+name: denotator type
+def: "A denotator type indicates how a term should be interpreted from an ontological perspective." []
+is_a: IAO:0000102 ! data about an ontology part
+property_value: IAO:0000111 "denotator type" xsd:string
+property_value: IAO:0000112 "The Basic Formal Ontology ontology makes a distinction between Universals and defined classes, where the formal are \"natural kinds\" and the latter arbitrary collections of entities." xsd:string
+property_value: IAO:0000117 "Alan Ruttenberg" xsd:string
+property_value: IAO:0000119 "Barry Smith, Werner Ceusters" xsd:string
+
[Term]
id: NCBITaxon:1
name: root
@@ -143943,6 +143948,7 @@ xref: IUPHARobj:1852
xref: PIRSF:PIRSF002004
is_a: CHEBI:36080
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P08575
[Term]
id: PR:000001008
@@ -143960,6 +143966,7 @@ synonym: "platelet membrane glycoprotein Ia" EXACT []
synonym: "VLA-2 subunit alpha" EXACT []
xref: IUPHARobj:2440
is_a: PR:000001005 ! integrin alpha with A domain
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P17301
[Term]
id: PR:000001010
@@ -143975,6 +143982,7 @@ synonym: "ITGAE" EXACT PRO-short-label [PRO:DNx]
synonym: "mucosal lymphocyte 1 antigen" EXACT []
xref: IUPHARobj:2450
is_a: PR:000001005 ! integrin alpha with A domain
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P38570
[Term]
id: PR:000001012
@@ -143993,6 +144001,7 @@ synonym: "leukocyte adhesion receptor MO1" EXACT []
synonym: "neutrophil adherence receptor" EXACT []
xref: IUPHARobj:2452
is_a: PR:000001005 ! integrin alpha with A domain
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P11215
[Term]
id: PR:000001013
@@ -144009,6 +144018,7 @@ synonym: "leukocyte adhesion glycoprotein p150,95 alpha chain" EXACT []
synonym: "leukocyte adhesion receptor p150,95" EXACT []
xref: IUPHARobj:2454
is_a: PR:000001005 ! integrin alpha with A domain
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P20702
[Term]
id: PR:000001014
@@ -144021,6 +144031,7 @@ synonym: "CD45R" RELATED []
synonym: "CD45RABC" EXACT []
synonym: "PTPRC/iso:CD45RABC" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000001006 ! receptor-type tyrosine-protein phosphatase C
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P08575-3
[Term]
id: PR:000001015
@@ -144031,6 +144042,7 @@ comment: Category=sequence. Requested by=CL. Note: This isoform includes the reg
synonym: "CD45RA" EXACT []
synonym: "PTPRC/iso:CD45RA" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000050216 ! receptor-type tyrosine-protein phosphatase C isoform CD45R
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P08575-8
[Term]
id: PR:000001017
@@ -144043,6 +144055,7 @@ synonym: "CD45RO" EXACT [GOC:add, PRO:ADD]
synonym: "PTPRC/iso:CD45RO" EXACT PRO-short-label [PRO:DNx]
synonym: "T200" RELATED []
is_a: PR:000001006 ! receptor-type tyrosine-protein phosphatase C
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P08575-4
[Term]
id: PR:000001018
@@ -144100,6 +144113,7 @@ synonym: "NCAM-1" EXACT []
synonym: "NCAM1" EXACT PRO-short-label [PRO:DNx]
xref: IUPHARobj:2769
is_a: PR:000001023 ! neural cell adhesion molecule NCAM
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P13591
[Term]
id: PR:000001025
@@ -144125,6 +144139,7 @@ synonym: "gp200-MR6" EXACT []
synonym: "ly-75" EXACT []
synonym: "LY75" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000001025 ! C-type lectin with multiple lectin domains
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:000034294
[Term]
id: PR:000001083
@@ -144163,6 +144178,7 @@ synonym: "T-cell surface glycoprotein Lyt-2" EXACT []
synonym: "T-lymphocyte differentiation antigen T8/Leu-2" EXACT []
is_a: CHEBI:36080
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P01732
[Term]
id: PR:000001085
@@ -144181,6 +144197,7 @@ synonym: "T-cell surface glycoprotein Lyt-3" EXACT []
xref: PIRSF:PIRSF002020
is_a: CHEBI:36080
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P10966
[Term]
id: PR:000001087
@@ -144263,6 +144280,7 @@ synonym: "Drd1a" RELATED Gene-based []
synonym: "Gpcr15" RELATED Gene-based []
xref: IUPHARobj:214
is_a: PR:000001107 ! D(1)-like dopamine receptor
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P21728
[Term]
id: PR:000001177
@@ -144274,6 +144292,7 @@ synonym: "dopamine D2 receptor" EXACT []
synonym: "DRD2" EXACT PRO-short-label [PRO:DNx]
xref: IUPHARobj:215
is_a: PR:000001108 ! D(2)-like dopamine receptor
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P14416
[Term]
id: PR:000001197
@@ -144303,6 +144322,7 @@ synonym: "MCP-1-R" EXACT []
synonym: "monocyte chemoattractant protein 1 receptor" EXACT []
xref: IUPHARobj:59
is_a: PR:000001128 ! chemokine receptor
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P41597
[Term]
id: PR:000001200
@@ -144320,6 +144340,7 @@ synonym: "CMKBR4" RELATED Gene-based []
synonym: "K5-5" EXACT []
xref: IUPHARobj:61
is_a: PR:000001128 ! chemokine receptor
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P51679
[Term]
id: PR:000001201
@@ -144339,6 +144360,7 @@ synonym: "HIV-1 fusion coreceptor" EXACT []
synonym: "MIP-1 alpha receptor" EXACT []
xref: IUPHARobj:62
is_a: PR:000001128 ! chemokine receptor
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P51681
[Term]
id: PR:000001202
@@ -144366,6 +144388,7 @@ synonym: "LARC receptor" EXACT []
synonym: "STRL22" RELATED Gene-based []
xref: IUPHARobj:63
is_a: PR:000001128 ! chemokine receptor
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P51684
[Term]
id: PR:000001203
@@ -144390,6 +144413,7 @@ synonym: "EVI1" RELATED Gene-based []
synonym: "MIP-3 beta receptor" EXACT []
xref: IUPHARobj:64
is_a: PR:000001128 ! chemokine receptor
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P32248
[Term]
id: PR:000001206
@@ -144411,6 +144435,7 @@ synonym: "V28" EXACT []
xref: IUPHARobj:74
xref: PIRSF:PIRSF501025
is_a: PR:000001128 ! chemokine receptor
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P49238
[Term]
id: PR:000001207
@@ -144432,6 +144457,7 @@ synonym: "IP-10 receptor" EXACT []
xref: IUPHARobj:70
xref: PIRSF:PIRSF501023
is_a: PR:000001128 ! chemokine receptor
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P49682
[Term]
id: PR:000001208
@@ -144460,6 +144486,7 @@ synonym: "stromal cell-derived factor 1 receptor" EXACT []
xref: IUPHARobj:71
xref: PIRSF:PIRSF501021
is_a: PR:000001128 ! chemokine receptor
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P61073
[Term]
id: PR:000001209
@@ -144481,6 +144508,7 @@ synonym: "MDR15" RELATED Gene-based []
synonym: "monocyte-derived receptor 15" EXACT []
xref: IUPHARobj:72
is_a: PR:000001128 ! chemokine receptor
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P32302
[Term]
id: PR:000001224
@@ -144499,6 +144527,7 @@ synonym: "Opn1mw" RELATED []
synonym: "OPN1MW2" RELATED []
xref: IUPHARobj:2962
is_a: PR:000001119 ! animal opsin
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:000050522
[Term]
id: PR:000001226
@@ -144521,6 +144550,7 @@ synonym: "OPN4" EXACT PRO-short-label [PRO:DNx]
synonym: "opsin-4" EXACT []
xref: IUPHARobj:2758
is_a: PR:000001119 ! animal opsin
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:Q9UHM6
[Term]
id: PR:000001244
@@ -144535,6 +144565,7 @@ synonym: "red-sensitive opsin" EXACT []
synonym: "ROP" EXACT []
xref: IUPHARobj:2961
is_a: PR:000001119 ! animal opsin
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P04000
[Term]
id: PR:000001254
@@ -144558,6 +144589,7 @@ synonym: "RANTES-R" EXACT []
synonym: "SCYAR1" RELATED Gene-based []
xref: IUPHARobj:58
is_a: PR:000001197 ! chemokine receptor CCR1/3/1L
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P32246
[Term]
id: PR:000001255
@@ -144579,6 +144611,7 @@ synonym: "macrophage inflammatory protein 1-alpha receptor-like 2" EXACT []
synonym: "MIP-1 alpha RL2" EXACT []
xref: IUPHARobj:60
is_a: PR:000001197 ! chemokine receptor CCR1/3/1L
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P51677
[Term]
id: PR:000001256
@@ -144598,6 +144631,7 @@ synonym: "IL-8R A" EXACT []
synonym: "IL8RA" RELATED Gene-based []
xref: IUPHARobj:68
is_a: PR:000001226 ! high affinity interleukin-8 receptor
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P25024
[Term]
id: PR:000001257
@@ -144619,6 +144653,7 @@ synonym: "IL-8R B" EXACT []
synonym: "IL8RB" RELATED Gene-based []
xref: IUPHARobj:69
is_a: PR:000001226 ! high affinity interleukin-8 receptor
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P25025
[Term]
id: PR:000001281
@@ -144647,6 +144682,7 @@ synonym: "T-cell surface antigen Leu-14" EXACT []
xref: IUPHARobj:2786
is_a: CHEBI:36080
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P20273
[Term]
id: PR:000001289
@@ -144699,6 +144735,7 @@ synonym: "HECL" RELATED Gene-based []
synonym: "UNQ9361/PRO34150" RELATED Gene-based []
is_a: CHEBI:36080
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:Q8WTT0
[Term]
id: PR:000001293
@@ -144711,6 +144748,7 @@ synonym: "CLEC4K" RELATED Gene-based []
synonym: "langerin" EXACT []
is_a: CHEBI:36080
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:Q9UJ71
[Term]
id: PR:000001300
@@ -144824,6 +144862,7 @@ synonym: "TQ1" EXACT []
xref: PIRSF:PIRSF002421
is_a: CHEBI:36080
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P14151
[Term]
id: PR:000001319
@@ -144839,6 +144878,7 @@ synonym: "signaling lymphocytic activation molecule 5" EXACT []
synonym: "SLAMF5" RELATED Gene-based []
is_a: CHEBI:36080
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:Q9UIB8
[Term]
id: PR:000001320
@@ -144864,6 +144904,7 @@ synonym: "tetherin" EXACT []
xref: PIRSF:PIRSF023920
is_a: CHEBI:36080
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:Q10589
[Term]
id: PR:000001327
@@ -144889,6 +144930,7 @@ synonym: "CGM6" RELATED Gene-based []
synonym: "non-specific cross-reacting antigen NCA-95" EXACT []
is_a: CHEBI:36080
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P31997
[Term]
id: PR:000001337
@@ -144902,6 +144944,7 @@ synonym: "CD35" EXACT []
synonym: "CR1" EXACT PRO-short-label [PRO:DNx]
is_a: CHEBI:36080
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P17927
[Term]
id: PR:000001338
@@ -144919,6 +144962,7 @@ synonym: "epstein-Barr virus receptor" EXACT []
xref: PIRSF:PIRSF002484
is_a: CHEBI:36080
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P20023
[Term]
id: PR:000001343
@@ -144957,6 +145001,7 @@ synonym: "phosphodiesterase I beta" EXACT []
synonym: "phosphodiesterase I/nucleotide pyrophosphatase 3" EXACT []
is_a: CHEBI:36080
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:O14638
[Term]
id: PR:000001345
@@ -144973,6 +145018,7 @@ xref: IUPHARobj:2895
xref: PIRSF:PIRSF038746
is_a: CHEBI:36080
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P17813
[Term]
id: PR:000001350
@@ -144986,6 +145032,7 @@ synonym: "JM2" RELATED Gene-based []
synonym: "scurfin" EXACT []
is_a: CHEBI:36080
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:Q9BZS1
[Term]
id: PR:000001352
@@ -145037,6 +145084,7 @@ xref: IUPHARobj:1695
xref: PIRSF:PIRSF001954
is_a: CHEBI:36080
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P01589
[Term]
id: PR:000001381
@@ -145056,6 +145104,7 @@ synonym: "p75" BROAD [PRO:DNx]
xref: IUPHARobj:1696
is_a: CHEBI:36080
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P14784
[Term]
id: PR:000001398
@@ -145071,6 +145120,7 @@ synonym: "immunoglobulin-like transcript 7" EXACT []
synonym: "LILRA4" EXACT PRO-short-label [PRO:DNx]
xref: IUPHARobj:2896
is_a: PR:000044780 ! leukocyte immunoglobulin-like receptor subfamily member
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P59901
[Term]
id: PR:000001402
@@ -145115,6 +145165,7 @@ synonym: "NIM-R5 antigen" EXACT []
synonym: "T10" EXACT []
xref: IUPHARobj:2766
is_a: PR:000001281 ! ADP-ribosyl cyclase
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P28907
[Term]
id: PR:000001412
@@ -145177,6 +145228,7 @@ synonym: "CDH5" EXACT PRO-short-label [PRO:DNx]
synonym: "vascular endothelial cadherin" EXACT []
synonym: "VE-cadherin" EXACT []
is_a: PR:000001327 ! cadherin
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P33151
[Term]
id: PR:000001447
@@ -145194,6 +145246,7 @@ synonym: "epithelial cadherin" EXACT []
synonym: "UVO" RELATED Gene-based []
synonym: "uvomorulin" EXACT []
is_a: PR:000001327 ! cadherin
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P12830
[Term]
id: PR:000001456
@@ -145214,6 +145267,7 @@ synonym: "FucT-IV" EXACT []
synonym: "FUT4" EXACT PRO-short-label [PRO:DNx]
synonym: "galactoside 3-L-fucosyltransferase" BROAD [PRO:DNx]
is_a: PR:000001320 ! alpha-(1,3)-fucosyltransferase
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P22083
[Term]
id: PR:000001460
@@ -145228,6 +145282,7 @@ synonym: "MN sialoglycoprotein" EXACT []
synonym: "PAS-2" EXACT []
synonym: "sialoglycoprotein alpha" EXACT []
is_a: PR:000001352 ! glycophorin
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P02724
[Term]
id: PR:000001465
@@ -145244,6 +145299,7 @@ synonym: "FcRI" EXACT []
synonym: "IGFR1" RELATED Gene-based []
synonym: "IgG Fc receptor I" EXACT []
is_a: PR:000001356 ! immunoglobulin gamma Fc receptor I
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P12314
[Term]
id: PR:000001479
@@ -145279,6 +145335,7 @@ synonym: "FcRII-b" EXACT []
synonym: "IGFR2" RELATED Gene-based []
synonym: "IgG Fc receptor II-b" EXACT []
is_a: PR:000001355 ! immunoglobulin gamma Fc receptor II/III/IV
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P31994
[Term]
id: PR:000001483
@@ -145356,6 +145413,7 @@ synonym: "N-formyl peptide receptor" BROAD [PRO:DNx]
synonym: "N-formylpeptide chemoattractant receptor" EXACT []
xref: IUPHARobj:222
is_a: PR:000001431 ! N-formyl peptide receptor
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P21462
[Term]
id: PR:000001635
@@ -145367,6 +145425,7 @@ synonym: "OT-R" EXACT []
synonym: "OXTR" EXACT PRO-short-label [PRO:DNx]
xref: IUPHARobj:369
is_a: PR:000001562 ! vasopressin/oxytocin receptor
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P30559
[Term]
id: PR:000001666
@@ -145381,6 +145440,7 @@ synonym: "relaxin family peptide receptor 1" EXACT []
synonym: "RXFP1" EXACT PRO-short-label [PRO:DNx]
xref: IUPHARobj:351
is_a: PR:000001551 ! relaxin family peptide receptor protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:Q9HBX9
[Term]
id: PR:000001753
@@ -145419,6 +145479,7 @@ synonym: "PROM1" EXACT PRO-short-label [PRO:DNx]
synonym: "prominin-like protein 1" EXACT []
synonym: "PROML1" RELATED Gene-based []
is_a: PR:000001785 ! prominin
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:O43490
[Term]
id: PR:000001806
@@ -145437,6 +145498,7 @@ synonym: "dendritic cell-associated C-type lectin 2" EXACT []
xref: IUPHARobj:2928
is_a: CHEBI:36080
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:Q6EIG7
[Term]
id: PR:000001807
@@ -145458,6 +145520,7 @@ synonym: "UNQ539/PRO1082" RELATED Gene-based []
xref: IUPHARobj:2927
is_a: CHEBI:36080
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:Q9BXN2
[Term]
id: PR:000001808
@@ -145508,6 +145571,7 @@ synonym: "TM7LN3" RELATED Gene-based []
xref: IUPHARobj:182
xref: PIRSF:PIRSF038685
is_a: PR:000001087 ! adhesion G-protein coupled receptor
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:Q14246
[Term]
id: PR:000001820
@@ -145557,6 +145621,7 @@ synonym: "TBX21" EXACT PRO-short-label [PRO:DNx]
synonym: "transcription factor TBLYM" EXACT []
is_a: CHEBI:36080
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:Q9UL17
[Term]
id: PR:000001836
@@ -145599,6 +145664,7 @@ synonym: "lymphocyte antigen T1/Leu-1" EXACT []
synonym: "Lyt-1" EXACT []
is_a: CHEBI:36080
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P06127
[Term]
id: PR:000001841
@@ -145611,6 +145677,7 @@ synonym: "TP44" EXACT []
xref: IUPHARobj:2863
is_a: CHEBI:36080
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P10747
[Term]
id: PR:000001843
@@ -145626,6 +145693,7 @@ synonym: "THY1" EXACT PRO-short-label [PRO:DNx]
xref: PIRSF:PIRSF038777
is_a: CHEBI:36080
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P04216
[Term]
id: PR:000001844
@@ -145639,6 +145707,7 @@ synonym: "type I arginase" EXACT []
xref: IUPHARobj:1244
is_a: CHEBI:36080
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P05089
[Term]
id: PR:000001850
@@ -145654,6 +145723,7 @@ synonym: "CTSO" RELATED Gene-based []
synonym: "CTSO2" RELATED Gene-based []
xref: IUPHARobj:2350
is_a: PR:000040662 ! cathepsin-like protease
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P43235
[Term]
id: PR:000001852
@@ -145668,6 +145738,7 @@ synonym: "cytotoxic T-lymphocyte-associated antigen 4" EXACT []
xref: IUPHARobj:2743
is_a: CHEBI:36080
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P16410
[Term]
id: PR:000001858
@@ -145685,6 +145756,7 @@ synonym: "VPREB1" EXACT PRO-short-label [PRO:DNx]
xref: PIRSF:PIRSF038787
is_a: CHEBI:36080
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P12018
[Term]
id: PR:000001859
@@ -145702,6 +145774,7 @@ synonym: "immunoglobulin omega polypeptide" EXACT []
synonym: "immunoglobulin-related protein 14.1" EXACT []
is_a: CHEBI:36080
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P15814
[Term]
id: PR:000001860
@@ -145720,6 +145793,7 @@ synonym: "ICOS" EXACT PRO-short-label [PRO:DNx]
xref: IUPHARobj:2939
is_a: CHEBI:36080
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:Q9Y6W8
[Term]
id: PR:000001861
@@ -145768,6 +145842,7 @@ xref: IUPHARobj:1706
xref: PIRSF:PIRSF018419
is_a: CHEBI:36080
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:Q01344
[Term]
id: PR:000001869
@@ -145786,6 +145861,7 @@ xref: IUPHARobj:1698
xref: PIRSF:PIRSF001960
is_a: CHEBI:36080
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P16871
[Term]
id: PR:000001874
@@ -145815,6 +145891,7 @@ synonym: "SPN" EXACT PRO-short-label [PRO:DNx]
xref: PIRSF:PIRSF001994
is_a: CHEBI:36080
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P16150
[Term]
id: PR:000001880
@@ -145838,6 +145915,7 @@ xref: IUPHARobj:2935
xref: PIRSF:PIRSF002426
is_a: CHEBI:36080
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P06734
[Term]
id: PR:000001883
@@ -145861,6 +145939,7 @@ synonym: "SCARA2" RELATED Gene-based []
synonym: "scavenger receptor class A member 2" EXACT []
is_a: CHEBI:36080
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:Q9UEW3
[Term]
id: PR:000001885
@@ -145878,6 +145957,7 @@ synonym: "Scvr" RELATED Gene-based []
synonym: "SR-A" EXACT []
is_a: CHEBI:36080
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P21757
[Term]
id: PR:000001888
@@ -145937,6 +146017,7 @@ synonym: "NK-p46" EXACT []
synonym: "NKp46" EXACT []
is_a: CHEBI:36080
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:O76036
[Term]
id: PR:000001894
@@ -145955,6 +146036,7 @@ synonym: "NKp44" EXACT []
xref: PIRSF:PIRSF037963
is_a: CHEBI:36080
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:O95944
[Term]
id: PR:000001896
@@ -145975,6 +146057,7 @@ synonym: "SLAM family member 4" EXACT []
synonym: "SLAMF4" EXACT []
is_a: CHEBI:36080
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:Q9BZW8
[Term]
id: PR:000001897
@@ -146008,6 +146091,7 @@ xref: IUPHARobj:1611
xref: PIRSF:PIRSF501074
is_a: CHEBI:36080
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P08473
[Term]
id: PR:000001902
@@ -146029,6 +146113,7 @@ synonym: "TOR" EXACT []
xref: IUPHARobj:600
is_a: CHEBI:36080
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P51449
[Term]
id: PR:000001903
@@ -146042,6 +146127,7 @@ synonym: "Pax-5" RELATED Gene-based []
synonym: "PAX5" EXACT PRO-short-label [PRO:DNx]
is_a: CHEBI:36080
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:Q02548
[Term]
id: PR:000001905
@@ -146065,6 +146151,7 @@ synonym: "platelet glycoprotein IV" EXACT []
synonym: "thrombospondin receptor" EXACT []
is_a: CHEBI:36080
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P16671
[Term]
id: PR:000001907
@@ -146082,6 +146169,7 @@ synonym: "GPIbA" EXACT []
xref: PIRSF:PIRSF002493
is_a: CHEBI:36080
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P07359
[Term]
id: PR:000001919
@@ -146098,6 +146186,7 @@ xref: IUPHARobj:2760
xref: PIRSF:PIRSF018380
is_a: CHEBI:36080
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:Q15116
[Term]
id: PR:000001925
@@ -146110,6 +146199,7 @@ synonym: "hemoglobin scavenger receptor" EXACT []
synonym: "M130" RELATED Gene-based []
is_a: CHEBI:36080
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:Q86VB7
[Term]
id: PR:000001927
@@ -146131,6 +146221,7 @@ synonym: "SIGLEC5" EXACT PRO-short-label [PRO:DNx]
synonym: "Siglecf" RELATED []
is_a: CHEBI:36080
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:O15389
[Term]
id: PR:000001928
@@ -146150,6 +146241,7 @@ synonym: "siglec-6" EXACT []
synonym: "SIGLEC6" EXACT PRO-short-label [PRO:DNx]
is_a: CHEBI:36080
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:O43699
[Term]
id: PR:000001931
@@ -146167,6 +146259,7 @@ synonym: "SIGLEC1" EXACT PRO-short-label [PRO:DNx]
synonym: "SN" RELATED Gene-based []
is_a: CHEBI:36080
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:Q9BZZ2
[Term]
id: PR:000001932
@@ -146186,6 +146279,7 @@ synonym: "small cell lung carcinoma cluster 4 antigen" EXACT []
synonym: "X62 heat stable antigen" EXACT []
is_a: CHEBI:36080
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P25063
[Term]
id: PR:000001935
@@ -146201,6 +146295,7 @@ synonym: "SYND1" EXACT []
xref: PIRSF:PIRSF015854
is_a: CHEBI:36080
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P18827
[Term]
id: PR:000001937
@@ -146218,6 +146313,7 @@ synonym: "type 5 acid phosphatase" EXACT []
xref: PIRSF:PIRSF000898
is_a: CHEBI:36080
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P13686
[Term]
id: PR:000001938
@@ -146240,6 +146336,7 @@ synonym: "GATA-binding factor 3" EXACT []
synonym: "GATA3" EXACT PRO-short-label [PRO:DNx]
is_a: CHEBI:36080
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P23771
[Term]
id: PR:000001944
@@ -146254,6 +146351,7 @@ synonym: "Sfpi1" RELATED Gene-based []
synonym: "SPI1" EXACT PRO-short-label [PRO:DNx]
is_a: CHEBI:36080
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P17947
[Term]
id: PR:000001945
@@ -146271,6 +146369,7 @@ synonym: "TR" RELATED []
synonym: "Trfr" RELATED Gene-based []
is_a: CHEBI:36080
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P02786
[Term]
id: PR:000001950
@@ -146306,6 +146405,7 @@ xref: IUPHARobj:1881
xref: PIRSF:PIRSF038806
is_a: CHEBI:36080
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:Q9Y6Q6
[Term]
id: PR:000001963
@@ -146355,6 +146455,7 @@ synonym: "Sirp-alpha-3" EXACT []
synonym: "SIRPA" EXACT PRO-short-label [PRO:DNx]
xref: IUPHARobj:2942
is_a: PR:000001832 ! SIRP/SHPS-1 family protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P78324
[Term]
id: PR:000001969
@@ -146372,6 +146473,7 @@ synonym: "uPAR" EXACT []
xref: PIRSF:PIRSF002022
is_a: CHEBI:36080
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:Q03405
[Term]
id: PR:000001971
@@ -146415,6 +146517,7 @@ synonym: "tyrosine-protein kinase receptor FLT3" EXACT []
xref: IUPHARobj:1807
xref: PIRSF:PIRSF500949
is_a: PR:000001810 ! CSF-1/PDGF receptor-type tyrosine-protein kinase
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P36888
[Term]
id: PR:000002015
@@ -146444,6 +146547,7 @@ synonym: "NKG2-A/B-activating NK receptor" EXACT []
synonym: "NKG2A" RELATED Gene-based []
xref: IUPHARobj:2849
is_a: PR:000001897 ! natural killer cell receptor NKG2
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P26715
[Term]
id: PR:000002025
@@ -146456,6 +146560,7 @@ synonym: "CD1a" EXACT []
synonym: "T-cell surface antigen T6/Leu-6" EXACT []
synonym: "Ta1 thymocyte antigen" EXACT []
is_a: PR:000001838 ! T-cell surface glycoprotein CD1
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P06126
[Term]
id: PR:000002027
@@ -146466,6 +146571,7 @@ comment: Category=gene. Requested by=CL.
synonym: "CD1C" EXACT PRO-short-label [PRO:DNx]
synonym: "CD1c" EXACT []
is_a: PR:000001838 ! T-cell surface glycoprotein CD1
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P29017
[Term]
id: PR:000002028
@@ -146481,6 +146587,7 @@ synonym: "Cd1d1" RELATED Gene-based []
synonym: "R3G1" EXACT []
synonym: "T-cell surface glycoprotein CD1d" EXACT []
is_a: PR:000001838 ! T-cell surface glycoprotein CD1
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P15813
[Term]
id: PR:000002030
@@ -146524,6 +146631,7 @@ synonym: "myeloid plasma membrane glycoprotein CD13" EXACT []
synonym: "PEPN" RELATED Gene-based []
xref: IUPHARobj:1560
is_a: PR:000001888 ! membrane alanyl aminopeptidase-like metallopeptidase
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P15144
[Term]
id: PR:000002037
@@ -146547,6 +146655,7 @@ synonym: "lymphocyte antigen 68" EXACT []
synonym: "matrix-remodeling-associated protein 4" EXACT []
synonym: "MXRA4" RELATED Gene-based []
is_a: PR:000001938 ! thrombomodulin-like receptor
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:Q9NPY3
[Term]
id: PR:000002039
@@ -146563,6 +146672,7 @@ synonym: "EAP" RELATED []
synonym: "ENPEP" EXACT PRO-short-label [PRO:DNx]
xref: IUPHARobj:1568
is_a: PR:000001888 ! membrane alanyl aminopeptidase-like metallopeptidase
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:Q07075
[Term]
id: PR:000002062
@@ -146582,6 +146692,7 @@ synonym: "proto-oncogene c-Fms" EXACT []
xref: IUPHARobj:1806
xref: PIRSF:PIRSF500947
is_a: PR:000001810 ! CSF-1/PDGF receptor-type tyrosine-protein kinase
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P07333
[Term]
id: PR:000002064
@@ -146592,6 +146703,7 @@ comment: Category=gene. Requested by=CL.
synonym: "CD68" EXACT PRO-short-label [PRO:DNx]
synonym: "gp110" RELATED []
is_a: PR:000001883 ! lysosome-associated membrane protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P34810
[Term]
id: PR:000002065
@@ -146623,6 +146735,7 @@ synonym: "THBD" EXACT PRO-short-label [PRO:DNx]
synonym: "THRM" RELATED Gene-based []
synonym: "TM" EXACT []
is_a: PR:000001938 ! thrombomodulin-like receptor
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P07204
[Term]
id: PR:000002112
@@ -146642,6 +146755,7 @@ synonym: "VEGFR-2" EXACT []
synonym: "VEGFR2" RELATED Gene-based []
xref: IUPHARobj:1813
is_a: PR:000001971 ! vascular endothelial growth factor receptor
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P35968
[Term]
id: PR:000002123
@@ -146665,6 +146779,7 @@ synonym: "small-inducible cytokine A3" EXACT []
synonym: "tonsillar lymphocyte LD78 alpha protein" EXACT []
synonym: "TY-5" EXACT []
is_a: PR:000001998 ! C-C motif chemokine 3/4
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P10147
[Term]
id: PR:000002972
@@ -146682,6 +146797,7 @@ synonym: "MMR" EXACT []
synonym: "MRC1" EXACT PRO-short-label [PRO:DNx]
synonym: "MRC1L1" RELATED Gene-based []
is_a: PR:000001025 ! C-type lectin with multiple lectin domains
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P22897
[Term]
id: PR:000002976
@@ -146788,6 +146904,7 @@ synonym: "alpha-1 type I collagen" EXACT []
synonym: "COL1A1" EXACT PRO-short-label [PRO:DNx]
synonym: "Cola1" RELATED Gene-based []
is_a: PR:000003263 ! collagen type I alpha chain
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P02452
[Term]
id: PR:000003450
@@ -146809,6 +146926,7 @@ synonym: "ZNF51" RELATED Gene-based []
xref: IUPHARobj:2957
is_a: CHEBI:36080
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P41182
[Term]
id: PR:000003455
@@ -146831,6 +146949,7 @@ synonym: "RING finger protein 74" EXACT []
synonym: "RNF74" RELATED Gene-based []
is_a: CHEBI:36080
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P15918
[Term]
id: PR:000003460
@@ -146842,6 +146961,7 @@ synonym: "RAG-2" EXACT []
synonym: "RAG2" EXACT PRO-short-label [PRO:DNx]
is_a: CHEBI:36080
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P55895
[Term]
id: PR:000003463
@@ -146869,6 +146989,7 @@ synonym: "PFP" RELATED Gene-based []
synonym: "PRF1" EXACT PRO-short-label [PRO:DNx]
is_a: CHEBI:36080
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P14222
[Term]
id: PR:000003469
@@ -146911,6 +147032,7 @@ synonym: "SECT" EXACT []
synonym: "T-cell serine protease 1-3E" EXACT []
xref: IUPHARobj:2369
is_a: PR:000003505 ! leukocyte granule-associated proteinase
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P10144
[Term]
id: PR:000003505
@@ -146949,6 +147071,7 @@ synonym: "P1/Pk synthase" EXACT []
synonym: "UDP-galactose:beta-D-galactosyl-beta1-R 4-alpha-D-galactosyltransferase" EXACT []
is_a: CHEBI:36080
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:Q9NPC4
[Term]
id: PR:000004528
@@ -146964,6 +147087,7 @@ synonym: "UFO" RELATED Gene-based []
xref: IUPHARobj:1835
is_a: CHEBI:36080
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P30530
[Term]
id: PR:000004724
@@ -146976,6 +147100,7 @@ synonym: "vitelliform macular dystrophy 2-like protein 2" EXACT []
synonym: "VMD2L2" RELATED Gene-based []
is_a: CHEBI:36080
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:Q8NFU0
[Term]
id: PR:000005110
@@ -146986,6 +147111,7 @@ comment: Category=gene.
synonym: "CCK" EXACT PRO-short-label [PRO:DNx]
is_a: CHEBI:36080
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P06307
[Term]
id: PR:000005178
@@ -147019,6 +147145,7 @@ synonym: "CEBP" RELATED Gene-based []
synonym: "CEBPA" EXACT PRO-short-label [PRO:DNx]
is_a: CHEBI:36080
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P49715
[Term]
id: PR:000005310
@@ -147031,6 +147158,7 @@ synonym: "CEBPE" EXACT PRO-short-label [PRO:DNx]
synonym: "Gm294" RELATED Gene-based []
is_a: CHEBI:36080
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:Q15744
[Term]
id: PR:000005444
@@ -147045,6 +147173,7 @@ synonym: "transmembrane protein MT75" EXACT []
synonym: "UNQ872/PRO1890" RELATED Gene-based []
is_a: CHEBI:36080
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:Q9H9P2
[Term]
id: PR:000005460
@@ -147057,6 +147186,7 @@ synonym: "CHRNA7" EXACT PRO-short-label [PRO:DNx]
synonym: "NACHRA7" RELATED Gene-based []
xref: IUPHARobj:468
is_a: PR:000044668 ! nicotinic acetylcholine receptor protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P36544
[Term]
id: PR:000006169
@@ -147099,6 +147229,7 @@ synonym: "terminal deoxynucleotidyltransferase" EXACT []
synonym: "terminal transferase" EXACT []
is_a: CHEBI:36080
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P04053
[Term]
id: PR:000007152
@@ -147112,6 +147243,7 @@ synonym: "EPP" RELATED Gene-based []
synonym: "EPX" EXACT PRO-short-label [PRO:DNx]
is_a: CHEBI:36080
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P11678
[Term]
id: PR:000007431
@@ -147126,6 +147258,7 @@ synonym: "FcERI" RELATED []
synonym: "IgE Fc receptor subunit alpha" EXACT []
xref: IUPHARobj:2933
is_a: PR:000001355 ! immunoglobulin gamma Fc receptor II/III/IV
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P12319
[Term]
id: PR:000007499
@@ -147141,6 +147274,7 @@ synonym: "HBGF-8" RELATED []
synonym: "heparin-binding growth factor 8" RELATED []
is_a: CHEBI:36080
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P55075
[Term]
id: PR:000007597
@@ -147156,6 +147290,7 @@ synonym: "proto-oncogene protein c-fos" EXACT []
synonym: "transcription factor AP-1 subunit c-Fos" EXACT []
is_a: CHEBI:36080
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P01100
[Term]
id: PR:000007636
@@ -147175,6 +147310,7 @@ synonym: "winged-helix transcription factor nude" EXACT []
xref: IUPHARobj:2958
is_a: CHEBI:36080
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:O15353
[Term]
id: PR:000007785
@@ -147191,6 +147327,7 @@ synonym: "glutamate decarboxylase 67 kDa isoform" EXACT []
xref: IUPHARobj:1272
is_a: CHEBI:36080
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:Q99259
[Term]
id: PR:000007857
@@ -147208,6 +147345,7 @@ synonym: "GF1" RELATED Gene-based []
synonym: "NF-E1 DNA-binding protein" EXACT []
is_a: CHEBI:36080
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P15976
[Term]
id: PR:000007858
@@ -147219,6 +147357,7 @@ synonym: "GATA-binding protein 2" EXACT []
synonym: "GATA2" EXACT PRO-short-label [PRO:DNx]
is_a: CHEBI:36080
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P23769
[Term]
id: PR:000007939
@@ -147229,6 +147368,7 @@ comment: Category=gene. Requested by=CL.
synonym: "GFAP" EXACT PRO-short-label [PRO:DNx]
is_a: CHEBI:36080
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P14136
[Term]
id: PR:000008457
@@ -147254,6 +147394,7 @@ synonym: "HBZ2" RELATED Gene-based []
synonym: "hemoglobin zeta chain" EXACT []
synonym: "zeta-globin" EXACT []
is_a: PR:000050467 ! hemoglobin subunit
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P02008
[Term]
id: PR:000008857
@@ -147290,6 +147431,7 @@ synonym: "UNQ2501/PRO19612" RELATED Gene-based []
xref: IUPHARobj:1739
is_a: CHEBI:36080
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:Q9NRM6
[Term]
id: PR:000008994
@@ -147309,6 +147451,7 @@ synonym: "T1" RELATED Gene-based []
xref: IUPHARobj:1735
is_a: CHEBI:36080
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:Q01638
[Term]
id: PR:000009054
@@ -147319,6 +147462,7 @@ comment: Category=gene.
synonym: "INS" EXACT PRO-short-label [PRO:DNx]
synonym: "insulin" BROAD [PRO:DAN]
is_a: PR:000045358 ! insulin family protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P01308
[Term]
id: PR:000009127
@@ -147335,6 +147479,7 @@ synonym: "ITGAB" RELATED Gene-based []
synonym: "platelet membrane glycoprotein IIb" EXACT []
xref: IUPHARobj:2441
is_a: PR:000025797 ! integrin alpha lacking A domain
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P08514
[Term]
id: PR:000009129
@@ -147352,6 +147497,7 @@ synonym: "lymphocyte Peyer patch adhesion molecules subunit alpha" EXACT []
synonym: "VLA-4 subunit alpha" EXACT []
xref: IUPHARobj:2443
is_a: PR:000025797 ! integrin alpha lacking A domain
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P13612
[Term]
id: PR:000009143
@@ -147365,6 +147511,7 @@ synonym: "ITGB7" EXACT PRO-short-label [PRO:DNx]
synonym: "M290 IEL antigen" EXACT []
xref: IUPHARobj:2461
is_a: PR:000001861 ! integrin beta
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P26010
[Term]
id: PR:000009344
@@ -147377,6 +147524,7 @@ synonym: "kisspeptin-1" EXACT []
synonym: "PP5098" RELATED Gene-based []
is_a: CHEBI:36080
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:Q15726
[Term]
id: PR:000009426
@@ -147395,6 +147543,7 @@ synonym: "mast cell function-associated antigen" EXACT []
synonym: "mast cell function-associated antigen 2F1" EXACT []
is_a: CHEBI:36080
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:Q96E93
[Term]
id: PR:000009616
@@ -147473,6 +147622,7 @@ synonym: "p25" BROAD [PRO:DNx]
synonym: "SV-40-induced 24P3 protein" EXACT []
is_a: CHEBI:36080
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P80188
[Term]
id: PR:000009766
@@ -147496,6 +147646,7 @@ synonym: "putative MAPK-activating protein PM12" EXACT []
synonym: "S-Lac lectin 1" EXACT []
is_a: CHEBI:36080
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P09382
[Term]
id: PR:000009793
@@ -147526,6 +147677,7 @@ synonym: "LTF" EXACT PRO-short-label [PRO:DNx]
synonym: "talalactoferrin" EXACT []
is_a: CHEBI:36080
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P02788
[Term]
id: PR:000009981
@@ -147541,6 +147693,7 @@ synonym: "LUM" EXACT PRO-short-label [PRO:DNx]
synonym: "SLRR2D" RELATED Gene-based []
is_a: CHEBI:36080
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P51884
[Term]
id: PR:000010317
@@ -147554,6 +147707,7 @@ synonym: "MRG1" RELATED Gene-based []
synonym: "Stra10" RELATED Gene-based []
is_a: CHEBI:36080
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:O14770
[Term]
id: PR:000010329
@@ -147569,6 +147723,7 @@ synonym: "receptor tyrosine kinase MerTK" EXACT []
xref: IUPHARobj:1837
is_a: CHEBI:36080
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:Q12866
[Term]
id: PR:000010543
@@ -147580,6 +147735,7 @@ synonym: "MPO" EXACT PRO-short-label [PRO:DNx]
xref: IUPHARobj:2789
is_a: CHEBI:36080
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P05164
[Term]
id: PR:000010799
@@ -147603,6 +147759,7 @@ synonym: "BTCL1" RELATED Gene-based []
synonym: "NETO1" EXACT PRO-short-label [PRO:DNx]
is_a: CHEBI:36080
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:Q8TDF5
[Term]
id: PR:000011178
@@ -147619,6 +147776,7 @@ synonym: "NFKB2" EXACT PRO-short-label [PRO:DNx]
synonym: "nuclear factor of kappa light polypeptide gene enhancer in B-cells 2" EXACT []
synonym: "oncogene Lyt-10" EXACT []
is_a: PR:000001753 ! transcription factor NF-kappa-B subunit
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:Q00653
[Term]
id: PR:000011467
@@ -147633,6 +147791,7 @@ synonym: "NTNG1" EXACT PRO-short-label [PRO:DNx]
synonym: "UNQ571/PRO1133" RELATED Gene-based []
is_a: CHEBI:36080
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:Q9Y2I2
[Term]
id: PR:000012526
@@ -147645,6 +147804,7 @@ synonym: "PDYN" EXACT PRO-short-label [PRO:DNx]
synonym: "preprodynorphin" EXACT []
is_a: CHEBI:36080
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P01213
[Term]
id: PR:000013206
@@ -147659,6 +147819,7 @@ synonym: "PRG2" EXACT PRO-short-label [PRO:DNx]
synonym: "proteoglycan 2" EXACT []
is_a: CHEBI:36080
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P13727
[Term]
id: PR:000013246
@@ -147668,6 +147829,7 @@ def: "A somatotropin hormone family member that is a translation product of the
comment: Category=gene.
synonym: "PRL" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000029968 ! somatotropin hormone family member
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P01236
[Term]
id: PR:000013502
@@ -147679,6 +147841,7 @@ synonym: "Pva" RELATED Gene-based []
synonym: "PVALB" EXACT PRO-short-label [PRO:DNx]
is_a: CHEBI:36080
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P20472
[Term]
id: PR:000013879
@@ -147691,6 +147854,7 @@ synonym: "RELN" EXACT PRO-short-label [PRO:DNx]
synonym: "Rl" RELATED Gene-based []
is_a: CHEBI:36080
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P78509
[Term]
id: PR:000013883
@@ -147702,6 +147866,7 @@ synonym: "angiotensinogenase" RELATED []
synonym: "REN" EXACT PRO-short-label [PRO:DNx]
xref: IUPHARobj:2413
is_a: PR:000050025 ! angiotensinogenase
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P00797
[Term]
id: PR:000014046
@@ -147722,6 +147887,7 @@ synonym: "RNASE2" EXACT PRO-short-label [PRO:DNx]
synonym: "RNS2" RELATED Gene-based []
is_a: CHEBI:36080
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P10153
[Term]
id: PR:000014047
@@ -147736,6 +147902,7 @@ synonym: "RNASE3" EXACT PRO-short-label [PRO:DNx]
synonym: "RNS3" RELATED Gene-based []
is_a: CHEBI:36080
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P12724
[Term]
id: PR:000014362
@@ -147758,6 +147925,7 @@ synonym: "SL3-3 enhancer factor 1 alpha B subunit" EXACT []
synonym: "SL3/AKV core-binding factor alpha B subunit" EXACT []
is_a: CHEBI:36080
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:Q01196
[Term]
id: PR:000014505
@@ -147784,6 +147952,7 @@ synonym: "urine protein 1" EXACT []
synonym: "Utg" RELATED Gene-based []
is_a: CHEBI:36080
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P11684
[Term]
id: PR:000014841
@@ -147798,6 +147967,7 @@ synonym: "Shh unprocessed N-terminal signaling and C-terminal autoprocessing dom
synonym: "ShhNC" EXACT []
is_a: CHEBI:36080
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:Q15465
[Term]
id: PR:000015325
@@ -147815,6 +147985,7 @@ synonym: "SR" EXACT []
synonym: "synoretin" EXACT []
is_a: CHEBI:36080
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:O76070
[Term]
id: PR:000015426
@@ -147826,6 +147997,7 @@ synonym: "Sox-2" RELATED Gene-based []
synonym: "SOX2" EXACT PRO-short-label [PRO:DNx]
is_a: CHEBI:36080
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P48431
[Term]
id: PR:000015658
@@ -147838,6 +148010,7 @@ synonym: "SSPO" EXACT PRO-short-label [PRO:DNx]
synonym: "SSPOP" RELATED Gene-based []
is_a: CHEBI:36080
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:A2VEC9
[Term]
id: PR:000015665
@@ -147850,6 +148023,7 @@ synonym: "Smst" RELATED Gene-based []
synonym: "SST" EXACT PRO-short-label [PRO:DNx]
is_a: CHEBI:36080
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P61278
[Term]
id: PR:000016004
@@ -147867,6 +148041,7 @@ synonym: "UNQ585/PRO1155" RELATED Gene-based []
synonym: "ZNEUROK1" EXACT []
is_a: CHEBI:36080
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:Q9UHF0
[Term]
id: PR:000016043
@@ -147885,6 +148060,7 @@ synonym: "TAL1" EXACT PRO-short-label [PRO:DNx]
synonym: "TCL5" RELATED Gene-based []
is_a: CHEBI:36080
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P17542
[Term]
id: PR:000016301
@@ -147914,6 +148090,7 @@ synonym: "putative T1/ST2 receptor-binding protein" EXACT []
synonym: "TMED1" EXACT PRO-short-label [PRO:DNx]
is_a: CHEBI:36080
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:Q13445
[Term]
id: PR:000017298
@@ -147924,6 +148101,7 @@ comment: Category=gene.
synonym: "VIM" EXACT PRO-short-label [PRO:DNx]
is_a: CHEBI:36080
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P08670
[Term]
id: PR:000017299
@@ -147937,6 +148115,7 @@ synonym: "vasoactive intestinal polypeptides precursor" EXACT []
synonym: "VIP" EXACT PRO-short-label [PRO:DNx]
is_a: CHEBI:36080
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P01282
[Term]
id: PR:000018263
@@ -148354,6 +148533,7 @@ comment: Category=sequence. Requested by=CL.
synonym: "CD8A/iso:1" EXACT PRO-short-label [PRO:DNx]
synonym: "mCD8alpha" EXACT []
is_a: PR:000001084 ! T-cell surface glycoprotein CD8 alpha chain
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P01732-1
[Term]
id: PR:000025405
@@ -148443,6 +148623,7 @@ synonym: "Natural killer cell surface protein P1A" EXACT []
synonym: "NKR-P1A" BROAD [PRO:DNx]
synonym: "NKRP1A" RELATED Gene-based []
is_a: PR:000001874 ! KLRB1-like protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:Q12918
[Term]
id: PR:000025796
@@ -148559,6 +148740,7 @@ synonym: "LAMP5" EXACT PRO-short-label [PRO:DNx]
synonym: "lysosome-associated membrane protein 5" EXACT []
is_a: CHEBI:36080
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:Q9UJQ1
[Term]
id: PR:000034294
@@ -157075,7 +157257,6 @@ xref: MIAA:0000284
xref: SCTID:20795001
xref: VHOG:0000860
xref: Wikipedia:Skin
-is_a: CARO:0000000 ! anatomical entity
is_a: PR:000050567 ! protein-containing material entity
is_a: UBERON:0034944 {source="FMA"} ! zone of organ
relationship: has_part UBERON:0001003 ! skin epidermis
@@ -157316,7 +157497,6 @@ synonym: "skin appendage" EXACT [FMA:71012]
xref: CALOHA:TS-0051
xref: FMA:71012
xref: SCTID:276160000
-is_a: CARO:0010000 ! multicellular anatomical structure
is_a: UBERON:0013703 ! integumentary projection
relationship: attaches_to UBERON:0002097 ! skin of body
property_value: editor_note "Mammary glands develop by similar mechanisms, and there is an argument for including them here (e.g. http://www.ncbi.nlm.nih.gov/pubmed/20484386), but these structures do not fit the current definition (lactiferous glands are part of the integumentary system in FMA). Note the FMA class is a subdivision of epidermis, which may be too restrictive for our purposes here." xsd:string
@@ -157634,7 +157814,6 @@ xref: MESH:D015571
xref: NCIT:C52556
xref: UMLS:C1709369 {source="ncithesaurus:Ovarian_Follicle_Fluid"}
xref: Wikipedia:Follicular_fluid
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000463 ! organism substance
relationship: has_part CHEBI:17089
relationship: has_part UBERON:0000456 ! secretion of exocrine gland
@@ -157840,7 +158019,6 @@ xref: WBbt:0005189
xref: Wikipedia:Ganglion
xref: XAO:0000209
xref: ZFA:0000190
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000061 {source="https://github.com/obophenotype/uberon/issues/2495#issuecomment-1187364719"} ! anatomical structure
disjoint_from: UBERON:0002420 {inconsistent_with="BTO"} ! basal ganglion
relationship: composed_primarily_of UBERON:0003714 {source="EHDAA2"} ! neural tissue
@@ -158733,7 +158911,6 @@ xref: SCTID:361528000
xref: UMLS:C1284058 {source="ncithesaurus:Metanephric_Diverticulum"}
xref: VHOG:0000541
xref: Wikipedia:Ureteric_bud
-is_a: CARO:0000006 ! material anatomical entity
is_a: UBERON:0000083 ! mesonephric tubule
is_a: UBERON:0007499 {source="EHDAA2"} ! epithelial sac
is_a: UBERON:0012275 ! meso-epithelium
@@ -158832,7 +159009,6 @@ xref: SCTID:361456007
xref: UMLS:C1283994 {source="ncithesaurus:Inner_Cell_Mass"}
xref: VHOG:0000742
xref: Wikipedia:Inner_cell_mass
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0002050 ! embryonic structure
relationship: develops_from UBERON:0000358 {source="Wikipedia"} ! blastocyst
relationship: surrounded_by UBERON:0000088 {source="Wikipedia"} ! trophoblast
@@ -158864,7 +159040,6 @@ xref: NCIT:C93292
xref: SCTID:362839005
xref: UMLS:C0041178 {source="ncithesaurus:Trophoblast"}
xref: Wikipedia:Trophoblast
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0002050 ! embryonic structure
relationship: composed_primarily_of CL:0000351 ! trophoblast cell
relationship: develops_from UBERON:0004345 {source="MP-def", source="PMID:19829370"} ! trophectoderm
@@ -158893,7 +159068,6 @@ xref: FMA:293863
xref: NCIT:C34112
xref: UMLS:C1283997 {source="ncithesaurus:Bilaminar_Embryonic_Disc"}
xref: Wikipedia:Bilaminar_disc
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0002050 ! embryonic structure
relationship: develops_from UBERON:0000087 {source="Wikipedia"} ! inner cell mass
property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/e3/Gray21.png" xsd:anyURI
@@ -159190,7 +159364,10 @@ relationship: only_in_taxon NCBITaxon:6072 ! Eumetazoa
relationship: part_of UBERON:0000068 ! embryo stage
relationship: preceded_by UBERON:0000109 ! gastrula stage
relationship: simultaneous_with GO:0001841 ! neural tube formation
+property_value: RO:0002174 NCBITaxon:7955
+property_value: seeAlso "https://github.com/obophenotype/developmental-stage-ontologies/issues/84" xsd:anyURI
property_value: seeAlso "https://github.com/obophenotype/uberon/issues/343" xsd:anyURI
+property_value: UBPROP:0000008 "In zebrafish, the times of neurulation and segmentation overlap so extensively there is no distinct neurula period of development, such as occurs largely before segmentation in amphibian embryos." xsd:string
[Term]
id: UBERON:0000111
@@ -159209,8 +159386,9 @@ is_a: BFO:0000003 ! occurrent
is_a: UBERON:0000105 ! life cycle stage
relationship: only_in_taxon NCBITaxon:6072 ! Eumetazoa
relationship: part_of UBERON:0000068 ! embryo stage
-relationship: preceded_by UBERON:0000110 ! neurula stage
+relationship: preceded_by UBERON:0000110 {gci_relation="part_of", gci_filler="NCBITaxon:32523"} ! neurula stage
relationship: simultaneous_with GO:0048513 ! animal organ development
+property_value: seeAlso "https://github.com/obophenotype/developmental-stage-ontologies/issues/84" xsd:anyURI
property_value: seeAlso "https://github.com/obophenotype/uberon/issues/533" xsd:anyURI
[Term]
@@ -159300,7 +159478,6 @@ synonym: "pulmonary epithelium" RELATED [BTO:0001653]
xref: BTO:0001653
xref: EMAPA:32860
xref: MA:0001783
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0004815 ! lower respiratory tract epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0002048 ! lung
@@ -159348,7 +159525,6 @@ xref: SCTID:361427007
xref: UMLS:C1514420 {source="ncithesaurus:Primary_Bronchial_Bud"}
xref: UMLS:C1514897 {source="ncithesaurus:Respiratory_Diverticulum"}
xref: Wikipedia:Respiratory_bud
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0005153 {source="GO:0060441"} ! epithelial bud
relationship: adjacent_to UBERON:0004872 ! splanchnic layer of lateral plate mesoderm
relationship: develops_from UBERON:0005597 ! lung primordium
@@ -159567,7 +159743,6 @@ xref: SCTID:361385000
xref: TAO:0001113
xref: Wikipedia:Theca_of_follicle
xref: ZFA:0001113
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000119 ! cell layer
is_a: UBERON:0005156 ! reproductive structure
intersection_of: UBERON:0000119 ! cell layer
@@ -159621,7 +159796,6 @@ xref: NCIT:C12375
xref: SCTID:245438008
xref: UMLS:C0227411 {source="ncithesaurus:Anal_Canal"}
xref: Wikipedia:Anal_canal
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0004111 ! anatomical conduit
relationship: channel_for UBERON:0001988 ! feces
relationship: continuous_with UBERON:0001052 ! rectum
@@ -159733,7 +159907,6 @@ xref: EHDAA2:0000256
xref: EHDAA:4895
xref: EMAPA:27573
xref: Wikipedia:Cloaca_(embryology)
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000162 ! cloaca
relationship: has_developmental_contribution_from UBERON:0003064 ! intermediate mesoderm
relationship: part_of UBERON:0000922 ! embryo
@@ -159760,7 +159933,6 @@ xref: SCTID:50961009
xref: UMLS:C0231057 {source="ncithesaurus:Urogenital_Sinus"}
xref: VHOG:0000414
xref: Wikipedia:Definitive_urogenital_sinus
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0002050 ! embryonic structure
relationship: contributes_to_morphology_of UBERON:0000163 ! embryonic cloaca
relationship: develops_from UBERON:0003064 ! intermediate mesoderm
@@ -159824,7 +159996,6 @@ xref: Wikipedia:Mouth
xref: XAO:0003029
xref: ZFA:0000547
xref: ZFA:0000590
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0004921 {notes="the mouth contains structures such as jaw skeleton that may not strictly be considered tract parts"} ! subdivision of digestive tract
intersection_of: UBERON:0004921 ! subdivision of digestive tract
intersection_of: proximalmost_part_of UBERON:0001555 ! digestive tract
@@ -159925,7 +160096,6 @@ synonym: "lungs pair" EXACT []
synonym: "pulmones" EXACT LATIN [FMA:68877, FMA:TA]
synonym: "set of lungs" EXACT []
xref: FMA:68877
-is_a: CARO:0000006 ! material anatomical entity
is_a: UBERON:0034925 ! anatomical collection
intersection_of: UBERON:0034925 ! anatomical collection
intersection_of: has_member UBERON:0002167 ! right lung
@@ -160044,7 +160214,6 @@ xref: VHOG:0000224
xref: Wikipedia:Blood
xref: XAO:0000124
xref: ZFA:0000007
-is_a: CARO:0000000 ! anatomical entity
is_a: PR:000050567 ! protein-containing material entity
is_a: UBERON:0000179 ! haemolymphatic fluid
relationship: has_part CL:0000232 {source="CL:tm"} ! erythrocyte
@@ -160124,7 +160293,6 @@ id: UBERON:0000202
name: glial blood brain barrier
namespace: uberon
def: "A blood brain barrier composed of glial cells." [https://orcid.org/0000-0002-6601-2165]
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000120 ! blood brain barrier
intersection_of: UBERON:0000120 ! blood brain barrier
intersection_of: composed_primarily_of CL:0000125 ! glial cell
@@ -160329,7 +160497,6 @@ xref: NCIT:C96299
xref: SCTID:361885006
xref: UMLS:C0224856 {source="ncithesaurus:Tendon_Sheath"}
xref: Wikipedia:Tendon_sheath
-is_a: CARO:0000000 ! anatomical entity
is_a: PR:000050567 ! protein-containing material entity
is_a: UBERON:0004923 ! organ component layer
intersection_of: UBERON:0004923 ! organ component layer
@@ -160361,7 +160528,6 @@ xref: SCTID:181457005
xref: UMLS:C0002630 {source="ncithesaurus:Amnion"}
xref: VHOG:0000721
xref: Wikipedia:Amnion
-is_a: CARO:0000000 ! anatomical entity
is_a: PR:000050567 ! protein-containing material entity
is_a: UBERON:0005631 ! extraembryonic membrane
relationship: develops_from UBERON:0005971 {source="ISBN:0073040584"} ! amniotic fold
@@ -160392,7 +160558,6 @@ xref: GAID:1294
xref: MESH:D036703
xref: OGEM:000006
xref: Wikipedia:Blastula
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000922 ! embryo
intersection_of: UBERON:0000468 ! multicellular organism
intersection_of: existence_starts_and_ends_during UBERON:0000108 ! blastula stage
@@ -160715,7 +160880,6 @@ xref: BTO:0000635
xref: FMA:74596
xref: SCTID:328639002
xref: SCTID:5023006
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0002371 ! bone marrow
intersection_of: UBERON:0002371 ! bone marrow
intersection_of: composed_primarily_of CL:0000136 ! fat cell
@@ -160859,7 +161023,6 @@ xref: SCTID:280210000
xref: UMLS:C0029082 {source="ncithesaurus:Ophthalmic_Nerve"}
xref: VHOG:0001349
xref: Wikipedia:Ophthalmic_nerve
-is_a: CARO:0001001 ! neuron projection bundle
is_a: UBERON:0001021 ! nerve
is_a: UBERON:0004121 ! ectoderm-derived structure
relationship: branching_part_of UBERON:0001645 {notes="may be a distinct nerve in teleosts", source="multiple"} ! trigeminal nerve
@@ -160996,7 +161159,6 @@ xref: NCIT:C13739
xref: SCTID:308837009
xref: UMLS:C1281743 {source="ncithesaurus:Blastocyst"}
xref: Wikipedia:Blastocyst
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0002050 ! embryonic structure
relationship: develops_from UBERON:0000085 ! morula
relationship: existence_starts_and_ends_during UBERON:0000108 ! blastula stage
@@ -161382,7 +161544,6 @@ xref: MAT:0000025
xref: MIAA:0000025
xref: VSAO:0000033
xref: XAO:0004042
-is_a: CARO:0000006 ! material anatomical entity
is_a: UBERON:0011216 ! organ system subdivision
intersection_of: UBERON:0011216 ! organ system subdivision
intersection_of: composed_primarily_of UBERON:0001015 ! musculature
@@ -161625,7 +161786,6 @@ xref: NCIT:C89807
xref: SCTID:181480002
xref: UMLS:C0036270 {source="ncithesaurus:Scalp"}
xref: Wikipedia:Scalp
-is_a: CARO:0000000 ! anatomical entity
is_a: PR:000050567 ! protein-containing material entity
is_a: UBERON:0034921 ! multi organ part structure
relationship: has_part UBERON:0000014 ! zone of skin
@@ -161745,7 +161905,6 @@ xref: NCIT:C83189
xref: SCTID:320101005
xref: UMLS:C0221931 {source="ncithesaurus:Dermal_Papilla"}
xref: Wikipedia:Dermal_papillae
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000479 ! tissue
relationship: composed_primarily_of CL:0000057 ! fibroblast
relationship: part_of UBERON:0001992 ! papillary layer of dermis
@@ -161805,7 +161964,6 @@ synonym: "myoepitheliocytus" RELATED LATIN [Wikipedia:Myoepithelial_cell]
xref: BTO:0002308
xref: FMA:67805
xref: Wikipedia:Myoepithelial_cell
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000488 ! atypical epithelium
intersection_of: UBERON:0000488 ! atypical epithelium
intersection_of: composed_primarily_of CL:0000185 ! myoepithelial cell
@@ -162976,7 +163134,6 @@ xref: FMA:259209
xref: MA:0000022
xref: SCTID:302551006
xref: Wikipedia:Thorax
-is_a: CARO:0010000 ! multicellular anatomical structure
is_a: UBERON:0009569 {source="FMA"} ! subdivision of trunk
is_a: UBERON:0011676 ! subdivision of organism along main body axis
intersection_of: UBERON:0011676 ! subdivision of organism along main body axis
@@ -163295,7 +163452,6 @@ xref: VHOG:0000139
xref: Wikipedia:Proctodeum
xref: XAO:0001019
xref: ZFA:0000066
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0016566 {source="EHDAA2"} ! pit
relationship: develops_from UBERON:0000924 ! ectoderm
relationship: has_potential_to_develop_into UBERON:0001353 ! anal region
@@ -163414,7 +163570,6 @@ xref: VHOG:0000543
xref: Wikipedia:Optic_nerve
xref: XAO:0000188
xref: ZFA:0000435
-is_a: CARO:0001001 ! neuron projection bundle
is_a: UBERON:0004121 ! ectoderm-derived structure
is_a: UBERON:0011215 ! central nervous system cell part cluster
is_a: UBERON:0034713 ! cranial neuron projection bundle
@@ -163824,7 +163979,6 @@ xref: SCTID:362880003
xref: UMLS:C0007776 {source="ncithesaurus:Cortex", source="BIRNLEX:1494"}
xref: VHOG:0000722
xref: Wikipedia:Cerebral_cortex
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0011215 ! central nervous system cell part cluster
is_a: UBERON:0016548 {source="FMA"} ! central nervous system gray matter layer
relationship: capable_of_part_of GO:0007613 {source="Wikipedia"} ! memory
@@ -164028,7 +164182,6 @@ xref: VHOG:0000164
xref: Wikipedia:Cornea
xref: XAO:0000180
xref: ZFA:0000640
-is_a: CARO:0000006 ! material anatomical entity
is_a: PR:000050567 ! protein-containing material entity
is_a: UBERON:0010000 ! multicellular anatomical structure
is_a: UBERON:0010313 ! neural crest-derived structure
@@ -164085,7 +164238,6 @@ xref: VHOG:0000169
xref: Wikipedia:Lens_(anatomy)
xref: XAO:0000008
xref: ZFA:0000035
-is_a: CARO:0000006 ! material anatomical entity
is_a: UBERON:0005389 ! transparent eye structure
relationship: contributes_to_morphology_of UBERON:0001801 ! anterior segment of eyeball
relationship: developmentally_induced_by UBERON:0003902 ! retinal neural layer
@@ -164362,7 +164514,6 @@ xref: SCTID:181609007
xref: UMLS:C0032225 {source="ncithesaurus:Pleural_Tissue"}
xref: VHOG:0000394
xref: Wikipedia:Pleura
-is_a: CARO:0000006 ! material anatomical entity
is_a: UBERON:0000042 ! serous membrane
intersection_of: UBERON:0000042 ! serous membrane
intersection_of: has_part UBERON:0002400 ! parietal pleura
@@ -164736,7 +164887,6 @@ xref: WBbt:0005747
xref: Wikipedia:Reproductive_system
xref: XAO:0000142
xref: ZFA:0000632
-is_a: CARO:0000006 ! material anatomical entity
is_a: UBERON:0000467 ! anatomical system
intersection_of: UBERON:0000467 ! anatomical system
intersection_of: capable_of_part_of GO:0000003 ! reproduction
@@ -164957,7 +165107,6 @@ xref: SCTID:181452004
xref: UMLS:C0042149 {source="ncithesaurus:Uterus"}
xref: VHOG:0001137
xref: Wikipedia:Uterus
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0013515 {source="cjm"} ! subdivision of oviduct
relationship: immediate_transformation_of UBERON:0005795 ! embryonic uterus
relationship: only_in_taxon NCBITaxon:32525 ! Theria
@@ -165502,7 +165651,6 @@ xref: VHOG:0001284
xref: Wikipedia:Adipose_tissue
xref: XAO:0003049
xref: ZFA:0005345
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0011822 {source="FMA"} ! dense irregular connective tissue
intersection_of: UBERON:0002384 ! connective tissue
intersection_of: composed_primarily_of CL:0000136 ! fat cell
@@ -165549,7 +165697,6 @@ xref: VSAO:0005038
xref: WBbt:0005737
xref: Wikipedia:Muscular_system
xref: ZFA:0000548
-is_a: CARO:0000006 ! material anatomical entity
is_a: UBERON:0011216 ! organ system subdivision
relationship: composed_primarily_of UBERON:0001630 ! muscle organ
relationship: part_of UBERON:0000383 ! musculature of body
@@ -165597,7 +165744,6 @@ xref: WBbt:0005735
xref: Wikipedia:Nervous_system
xref: XAO:0000177
xref: ZFA:0000396
-is_a: CARO:0000006 ! material anatomical entity
is_a: UBERON:0000467 ! anatomical system
disjoint_from: UBERON:0001033 ! gustatory system
disjoint_from: UBERON:0001434 ! skeletal system
@@ -165972,7 +166118,6 @@ xref: SCTID:362845002
xref: UMLS:C0043425 {source="ncithesaurus:Yolk_Sac"}
xref: VHOG:0000830
xref: Wikipedia:Yolk_sac
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0005292 ! extraembryonic tissue
is_a: UBERON:0005631 {seeAlso="https://github.com/obophenotype/uberon/issues/635"} ! extraembryonic membrane
is_a: UBERON:0007499 {source="EHDAA2"} ! epithelial sac
@@ -166049,7 +166194,6 @@ xref: VHOG:0000462
xref: Wikipedia:Pharynx
xref: XAO:0003227
xref: ZFA:0000056
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0006562 ! pharynx
relationship: continuous_with UBERON:0001043 {gci_relation="part_of", gci_filler="NCBITaxon:7742"} ! esophagus
relationship: develops_from UBERON:0009145 {source="EHDAA2"} ! pharyngeal region of foregut
@@ -166222,7 +166366,6 @@ xref: UMLS:C0231053 {source="ncithesaurus:Hindgut"}
xref: VHOG:0000459
xref: Wikipedia:Hindgut
xref: XAO:0000104
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0004921 ! subdivision of digestive tract
relationship: develops_from UBERON:0003104 {source="Wikipedia"} ! mesenchyme
relationship: proximally_connected_to UBERON:0001045 ! midgut
@@ -167594,7 +167737,6 @@ xref: VSAO:0000185
xref: Wikipedia:Vertebral_column
xref: XAO:0003074
xref: ZFA:0001559
-is_a: CARO:0000006 ! material anatomical entity
is_a: UBERON:0000075 ! subdivision of skeletal system
intersection_of: UBERON:0000075 ! subdivision of skeletal system
intersection_of: composed_primarily_of UBERON:0010913 ! vertebral element
@@ -168212,7 +168354,6 @@ xref: SCTID:181256004
xref: UMLS:C0007531 {source="ncithesaurus:Cecum"}
xref: VHOG:0001559
xref: Wikipedia:Cecum
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0009854 ! digestive tract diverticulum
relationship: continuous_with UBERON:0001156 {source="Wikipedia"} ! ascending colon
relationship: contributes_to_morphology_of UBERON:0000059 ! large intestine
@@ -168343,7 +168484,6 @@ xref: NCIT:C12265
xref: SCTID:362162009
xref: UMLS:C0227375 {source="ncithesaurus:Ascending_Colon"}
xref: Wikipedia:Ascending_colon
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000168 {source="FMA"} ! proximal-distal subdivision of colon
relationship: continuous_with UBERON:0001157 ! transverse colon
relationship: develops_from UBERON:0001045 {source="Wikipedia"} ! midgut
@@ -168374,7 +168514,6 @@ xref: NCIT:C12385
xref: SCTID:362163004
xref: UMLS:C0227386 {source="ncithesaurus:Transverse_Colon"}
xref: Wikipedia:Transverse_colon
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000168 {source="FMA"} ! proximal-distal subdivision of colon
relationship: continuous_with UBERON:0001158 ! descending colon
relationship: develops_from UBERON:0001045 {source="Wikipedia"} ! midgut
@@ -168404,7 +168543,6 @@ xref: NCIT:C12268
xref: SCTID:362165006
xref: UMLS:C0227389 {source="ncithesaurus:Descending_Colon"}
xref: Wikipedia:Descending_colon
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000168 {source="FMA"} ! proximal-distal subdivision of colon
relationship: continuous_with UBERON:0001159 ! sigmoid colon
relationship: develops_from UBERON:0001046 {source="Wikipedia"} ! hindgut
@@ -168438,7 +168576,6 @@ xref: SCTID:362166007
xref: UMLS:C0227391 {source="ncithesaurus:Sigmoid_Colon"}
xref: UMLS:C0682612 {source="ncithesaurus:Sigmoid_Flexure"}
xref: Wikipedia:Sigmoid_colon
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000168 {source="FMA"} ! proximal-distal subdivision of colon
relationship: continuous_with UBERON:0001052 ! rectum
relationship: develops_from UBERON:0001046 {source="Wikipedia"} ! hindgut
@@ -168475,7 +168612,6 @@ xref: SCTID:362139007
xref: UMLS:C0017129 {source="ncithesaurus:Fundus_of_the_Stomach"}
xref: VHOG:0000421
xref: Wikipedia:Fundus_(stomach)
-is_a: CARO:0000006 ! material anatomical entity
is_a: PR:000050567 ! protein-containing material entity
is_a: UBERON:0009870 ! zone of stomach
relationship: contributes_to_morphology_of UBERON:0000945 ! stomach
@@ -168578,7 +168714,6 @@ xref: NCIT:C12259
xref: SCTID:362142001
xref: UMLS:C0034193 {source="ncithesaurus:Antrum_Pylori"}
xref: Wikipedia:Pyloric_antrum
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0009870 {source="FMA"} ! zone of stomach
relationship: continuous_with UBERON:0001161 ! body of stomach
relationship: contributes_to_morphology_of UBERON:0001166 ! pylorus
@@ -168614,7 +168749,6 @@ xref: SCTID:362143006
xref: UMLS:C0034196 {source="ncithesaurus:Pylorus"}
xref: VHOG:0000420
xref: Wikipedia:Pylorus
-is_a: CARO:0000006 ! material anatomical entity
is_a: PR:000050567 ! protein-containing material entity
is_a: UBERON:0009870 ! zone of stomach
intersection_of: UBERON:0009870 ! zone of stomach
@@ -168931,7 +169065,6 @@ xref: SCTID:181616008
xref: UMLS:C1704247 {source="ncithesaurus:Peritoneal_Cavity"}
xref: VHOG:0000852
xref: Wikipedia:Peritoneal_cavity
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0035809 ! serous cavity
intersection_of: UBERON:0002553 ! anatomical cavity
intersection_of: adjacent_to UBERON:0001178 ! visceral peritoneum
@@ -169759,7 +169892,6 @@ xref: TAO:0005125
xref: UMLS:C1519988 {source="ncithesaurus:Villus"}
xref: Wikipedia:Intestinal_villus
xref: ZFA:0005125
-is_a: CARO:0000000 ! anatomical entity
is_a: PR:000050567 ! protein-containing material entity
is_a: UBERON:0004923 {source="FMA"} ! organ component layer
relationship: has_part UBERON:0001981 ! blood vessel
@@ -170091,7 +170223,6 @@ xref: UMLS:C0524448 {source="ncithesaurus:Bowman_s_Capsule"}
xref: Wikipedia:Bowman%27s_capsule
xref: ZFA:0005254
xref: ZFA:0005310
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000064 ! organ part
disjoint_from: UBERON:0002015 ! kidney capsule
relationship: capable_of_part_of GO:0003094 {source="Wikipedia"} ! glomerular filtration
@@ -170133,7 +170264,6 @@ xref: TAO:0001287
xref: UMLS:C0022674 {source="ncithesaurus:Renal_Tubule"}
xref: Wikipedia:Renal_tubule
xref: ZFA:0001287
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0004211 ! nephron epithelium
is_a: UBERON:0009773 {source="GO"} ! renal tubule
intersection_of: UBERON:0003914 {source="GO", source="MA", source="ZFA"} ! epithelial tube
@@ -170627,7 +170757,6 @@ xref: NCIT:C12992
xref: SCTID:27579002
xref: UMLS:C0229687 {source="ncithesaurus:Splenic_Red_Pulp"}
xref: Wikipedia:Red_pulp
-is_a: CARO:0000000 ! anatomical entity
is_a: PR:000050567 ! protein-containing material entity
is_a: UBERON:1000023 ! spleen pulp
relationship: composed_primarily_of CL:0000542 ! lymphocyte
@@ -170998,7 +171127,6 @@ xref: MA:0002417
xref: NCIT:C49268
xref: SCTID:247604006
xref: UMLS:C0227578 {source="ncithesaurus:Pancreatic_Acinus"}
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0013232 ! serous acinus
intersection_of: UBERON:0009842 ! glandular acinus
intersection_of: part_of UBERON:0000017 ! exocrine pancreas
@@ -171361,7 +171489,6 @@ xref: NCIT:C33342
xref: SCTID:362192000
xref: UMLS:C0227514 {source="ncithesaurus:Portal_Triad"}
xref: Wikipedia:Portal_triad
-is_a: CARO:0000000 ! anatomical entity
is_a: PR:000050567 ! protein-containing material entity
is_a: UBERON:0034921 ! multi organ part structure
relationship: contributes_to_morphology_of UBERON:0001171 ! portal lobule
@@ -171504,7 +171631,6 @@ xref: TAO:0002153
xref: UMLS:C0027713 {source="ncithesaurus:Nephron"}
xref: Wikipedia:Nephron
xref: ZFA:0005282
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000064 ! organ part
relationship: contributes_to_morphology_of UBERON:0002113 ! kidney
relationship: develops_from UBERON:0004208 {evidence="definitional"} ! nephrogenic mesenchyme
@@ -172366,7 +172492,6 @@ xref: SCTID:181050003
xref: UMLS:C0036394 {source="BIRNLEX:1133", source="ncithesaurus:Sciatic_Nerve"}
xref: VHOG:0000894
xref: Wikipedia:Sciatic_nerve
-is_a: CARO:0001001 ! neuron projection bundle
is_a: UBERON:0001021 ! nerve
relationship: innervates UBERON:0001511 ! skin of leg
relationship: overlaps UBERON:0000978 ! leg
@@ -172803,7 +172928,6 @@ xref: SCTID:181178004
xref: UMLS:C0013444 {source="ncithesaurus:External_Acoustic_Meatus"}
xref: VHOG:0000977
xref: Wikipedia:External_acoustic_meatus
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0004111 ! anatomical conduit
relationship: capable_of_part_of GO:0055127 ! vibrational conductance of sound to the inner ear
relationship: develops_from UBERON:0005872 {source="PMID:11237469"} ! 1st arch pharyngeal cleft
@@ -172835,7 +172959,6 @@ xref: SCTID:362680001
xref: UMLS:C0230120 {source="ncithesaurus:Anal_Region"}
xref: VHOG:0000395
xref: WBbt:0006919
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000475 ! organism subdivision
relationship: has_developmental_contribution_from UBERON:0000931 {evidence="cjm"} ! proctodeum
relationship: overlaps UBERON:0006866 ! terminal part of digestive tract
@@ -173000,7 +173123,6 @@ xref: TAO:0005131
xref: VHOG:0001527
xref: Wikipedia:Parietal_peritoneum
xref: ZFA:0005131
-is_a: CARO:0010000 ! multicellular anatomical structure
is_a: UBERON:0022351 ! parietal serous membrane
intersection_of: UBERON:0022351 ! parietal serous membrane
intersection_of: part_of UBERON:0002358 ! peritoneum
@@ -173873,7 +173995,6 @@ xref: NCIT:C13071
xref: SCTID:302549007
xref: UMLS:C0015450 {source="ncithesaurus:Face"}
xref: Wikipedia:Face
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0001444 ! subdivision of head
relationship: contributes_to_morphology_of UBERON:0000033 ! head
relationship: has_part UBERON:0000018 {gci_filler="NCBITaxon:50557", gci_relation="part_of"} ! compound eye
@@ -174149,7 +174270,6 @@ xref: SCTID:361103004
xref: UMLS:C0037004 {source="ncithesaurus:Shoulder"}
xref: VHOG:0000342
xref: Wikipedia:Shoulder
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000475 ! organism subdivision
relationship: has_part UBERON:0016884 ! shoulder joint
relationship: only_in_taxon NCBITaxon:32523 ! Tetrapoda
@@ -174314,7 +174434,6 @@ xref: UMLS:C0229889 {source="ncithesaurus:Lymphatic_Vessel"}
xref: VHOG:0001249
xref: Wikipedia:Lymphatic_vessel
xref: XAO:0000375
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000055 ! vessel
intersection_of: UBERON:0000055 ! vessel
intersection_of: part_of UBERON:0004536 ! lymph vasculature
@@ -174571,7 +174690,6 @@ xref: SCTID:182204005
xref: UMLS:C0022745 {source="ncithesaurus:Knee_Joint"}
xref: VHOG:0001003
xref: Wikipedia:Knee
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0003840 ! hindlimb joint
is_a: UBERON:0011139 ! synovial limb joint
intersection_of: UBERON:0000982 ! skeletal joint
@@ -174700,7 +174818,6 @@ xref: SCTID:182169008
xref: UMLS:C0013770 {source="ncithesaurus:Elbow_Joint"}
xref: VHOG:0000997
xref: Wikipedia:Elbow
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0003839 ! forelimb joint
is_a: UBERON:0011139 ! synovial limb joint
intersection_of: UBERON:0000982 ! skeletal joint
@@ -174760,7 +174877,6 @@ xref: NCIT:C52817
xref: SCTID:181009006
xref: UMLS:C0228885 {source="ncithesaurus:Axillary_Nerve"}
xref: Wikipedia:Axillary_nerve
-is_a: CARO:0001001 ! neuron projection bundle
is_a: UBERON:0003433 ! arm nerve
relationship: innervates UBERON:0009472 ! axilla
relationship: part_of UBERON:0001814 {source="MA"} ! brachial nerve plexus
@@ -174824,7 +174940,6 @@ xref: NCIT:C32150
xref: SCTID:181299009
xref: UMLS:C0003956 {source="ncithesaurus:Ascending_Aorta"}
xref: Wikipedia:Ascending_aorta
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0001515 ! thoracic aorta
relationship: contributes_to_morphology_of UBERON:0001515 ! thoracic aorta
relationship: develops_from UBERON:0005338 {source="EHDAA2"} ! outflow tract aortic component
@@ -174947,7 +175062,6 @@ xref: MA:0000475
xref: SCTID:181300001
xref: VHOG:0001196
xref: Wikipedia:Arch_of_aorta
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0001515 ! thoracic aorta
relationship: connected_to UBERON:0001496 ! ascending aorta
relationship: contributes_to_morphology_of UBERON:0001515 ! thoracic aorta
@@ -175563,7 +175677,7 @@ is_a: UBERON:0003644 ! kidney arterial blood vessel
relationship: branching_part_of UBERON:0009885 ! interlobar artery
relationship: part_of UBERON:0001225 {source="MA"} ! cortex of kidney
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
-property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/e/ee/Gray553.png" xsd:anyURI
+property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/8/87/2610_The_Kidney.jpg" xsd:anyURI
[Term]
id: UBERON:0001554
@@ -175619,7 +175733,6 @@ xref: UMLS:C0017189 {source="ncithesaurus:Gastrointestinal_Tract"}
xref: VHOG:0000309
xref: WBbt:0005743
xref: ZFA:0000112
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000025 ! tube
relationship: connects UBERON:0000165 ! mouth
relationship: immediate_transformation_of UBERON:0007026 {source="NCBIBook:NBK10107"} ! presumptive gut
@@ -175644,7 +175757,6 @@ xref: FMA:45659
xref: galen:LowerUrinaryTract
xref: MA:0002636
xref: SCTID:181420004
-is_a: CARO:0000006 ! material anatomical entity
is_a: UBERON:0011216 ! organ system subdivision
relationship: has_part UBERON:0000057 ! urethra
relationship: has_part UBERON:0001255 ! urinary bladder
@@ -175664,7 +175776,6 @@ xref: MA:0000442
xref: SCTID:361381009
xref: VHOG:0000406
xref: Wikipedia:Upper_respiratory_tract
-is_a: CARO:0000006 ! material anatomical entity
is_a: UBERON:0000072 ! proximo-distal subdivision of respiratory tract
relationship: has_part UBERON:0000004 ! nose
property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/9/9f/Illu_conducting_passages.svg" xsd:anyURI
@@ -175688,7 +175799,6 @@ xref: MA:0000435
xref: SCTID:281488008
xref: VHOG:0000382
xref: Wikipedia:Lower_respiratory_tract
-is_a: CARO:0000006 ! material anatomical entity
is_a: UBERON:0000072 ! proximo-distal subdivision of respiratory tract
relationship: has_part UBERON:0000170 ! pair of lungs
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
@@ -175947,7 +176057,6 @@ xref: VHOG:0000703
xref: Wikipedia:Olfactory_nerve
xref: XAO:0000426
xref: ZFA:0000249
-is_a: CARO:0001001 ! neuron projection bundle
is_a: UBERON:0001785 ! cranial nerve
is_a: UBERON:0004121 ! ectoderm-derived structure
intersection_of: UBERON:0001785 ! cranial nerve
@@ -176280,7 +176389,6 @@ xref: NCIT:C32463
xref: SCTID:280890008
xref: UMLS:C0229190 {source="ncithesaurus:Dilator_Pupillae_Muscle"}
xref: Wikipedia:Iris_dilator_muscle
-is_a: CARO:0010000 ! multicellular anatomical structure
is_a: UBERON:0004121 ! ectoderm-derived structure
is_a: UBERON:0004234 {source="BTO"} ! iris smooth muscle
relationship: develops_from UBERON:0002346 {source="ISBN:0781772214"} ! neurectoderm
@@ -176772,7 +176880,6 @@ xref: VHOG:0000704
xref: Wikipedia:Trigeminal_nerve
xref: XAO:0003092
xref: ZFA:0000697
-is_a: CARO:0001001 ! neuron projection bundle
is_a: UBERON:0001785 ! cranial nerve
intersection_of: UBERON:0001785 ! cranial nerve
intersection_of: extends_fibers_into UBERON:0002925 ! trigeminal nucleus
@@ -176841,7 +176948,6 @@ xref: VHOG:0000706
xref: Wikipedia:Facial_nerve
xref: XAO:0003094
xref: ZFA:0000664
-is_a: CARO:0001001 ! neuron projection bundle
is_a: UBERON:0001785 ! cranial nerve
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
intersection_of: UBERON:0001021 ! nerve
@@ -176911,7 +177017,6 @@ xref: VHOG:0000695
xref: Wikipedia:Vestibulocochlear_nerve
xref: XAO:0003095
xref: ZFA:0000247
-is_a: CARO:0001001 ! neuron projection bundle
is_a: UBERON:0001785 ! cranial nerve
is_a: UBERON:0004121 ! ectoderm-derived structure
intersection_of: UBERON:0001785 ! cranial nerve
@@ -176971,7 +177076,6 @@ xref: VHOG:0000701
xref: Wikipedia:Glossopharyngeal_nerve
xref: XAO:0003096
xref: ZFA:0000668
-is_a: CARO:0001001 ! neuron projection bundle
is_a: UBERON:0001785 ! cranial nerve
relationship: extends_fibers_into UBERON:0001896 ! medulla oblongata
relationship: has_developmental_contribution_from UBERON:0005239 {notes="motor", source="Wikipedia"} ! basal plate metencephalon
@@ -177026,7 +177130,6 @@ xref: UMLS:C0020614 {source="BIRNLEX:820", source="ncithesaurus:Hypoglossal_Nerv
xref: VHOG:0000693
xref: Wikipedia:Hypoglossal_nerve
xref: XAO:0004215
-is_a: CARO:0001001 ! neuron projection bundle
is_a: UBERON:0001785 ! cranial nerve
intersection_of: UBERON:0001785 ! cranial nerve
intersection_of: extends_fibers_into UBERON:0002871 ! hypoglossal nucleus
@@ -177716,7 +177819,6 @@ xref: TAO:0001580
xref: Wikipedia:Neuroranium
xref: XAO:0003170
xref: ZFA:0001580
-is_a: CARO:0000006 ! material anatomical entity
is_a: UBERON:0011158 {source="FMA"} ! primary subdivision of skull
relationship: develops_from UBERON:0004761 ! cartilaginous neurocranium
relationship: location_of UBERON:0000955 ! brain
@@ -177766,7 +177868,6 @@ xref: UMLS:C0027423 {source="ncithesaurus:Nasal_Cavity"}
xref: VHOG:0000271
xref: Wikipedia:Nasal_cavity
xref: ZFA:0000130
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0002553 ! anatomical cavity
relationship: develops_from UBERON:0005870 ! olfactory pit
relationship: part_of UBERON:0015788 {source="cjm"} ! olfactory apparatus chamber
@@ -177808,7 +177909,6 @@ xref: TAO:0001227
xref: UMLS:C0022359 {source="ncithesaurus:Jaw"}
xref: Wikipedia:Jaw
xref: ZFA:0001227
-is_a: CARO:0010000 ! multicellular anatomical structure
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
is_a: UBERON:0010912 ! subdivision of skeleton
intersection_of: UBERON:0010912 ! subdivision of skeleton
@@ -177848,7 +177948,6 @@ xref: ncithesaurus:Upper_Jaw
xref: SCTID:362636001
xref: VHOG:0000454
xref: Wikipedia:Upper_jaw
-is_a: CARO:0010000 ! multicellular anatomical structure
is_a: UBERON:0000475 ! organism subdivision
intersection_of: UBERON:0000475 ! organism subdivision
intersection_of: has_skeleton UBERON:0003277 ! skeleton of upper jaw
@@ -177885,7 +177984,6 @@ xref: ncithesaurus:Lower_Jaw
xref: SCTID:362637005
xref: VHOG:0000453
xref: Wikipedia:Lower_jaw
-is_a: CARO:0010000 ! multicellular anatomical structure
is_a: UBERON:0000475 ! organism subdivision
intersection_of: UBERON:0000475 ! organism subdivision
intersection_of: has_skeleton UBERON:0003278 ! skeleton of lower jaw
@@ -178200,7 +178298,6 @@ xref: EMAPA:18381
xref: FMA:54935
xref: SCTID:180543003
xref: XAO:0000105
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000464 ! anatomical space
intersection_of: UBERON:0000464 ! anatomical space
intersection_of: luminal_space_of UBERON:0006562 ! pharynx
@@ -178261,7 +178358,6 @@ xref: UMLS:C0023078 {source="ncithesaurus:Larynx"}
xref: VHOG:0001279
xref: Wikipedia:Larynx
xref: XAO:0003081
-is_a: CARO:0010000 ! multicellular anatomical structure
is_a: UBERON:0000072 ! proximo-distal subdivision of respiratory tract
relationship: contributes_to_morphology_of UBERON:0001004 ! respiratory system
relationship: develops_from UBERON:0008947 {source="EHDAA2"} ! respiratory primordium
@@ -178339,7 +178435,6 @@ xref: NCIT:C13049
xref: SCTID:181768009
xref: UMLS:C0024296 {source="ncithesaurus:Lymphoid_Tissue"}
xref: Wikipedia:Lymphoid_tissue
-is_a: CARO:0000000 ! anatomical entity
is_a: PR:000050567 ! protein-containing material entity
is_a: UBERON:0034769 {source="FMA"} ! lymphomyeloid tissue
relationship: has_part CL:0000542 ! lymphocyte
@@ -178403,7 +178498,6 @@ xref: EMAPA:37769 {source="MA:th"}
xref: FMA:55515
xref: MA:0000730
xref: SCTID:371402001
-is_a: CARO:0000006 ! material anatomical entity
is_a: PR:000050567 ! protein-containing material entity
is_a: UBERON:0000353 ! parenchyma
intersection_of: UBERON:0000353 ! parenchyma
@@ -178443,7 +178537,6 @@ synonym: "parenchyma of parathyroid" EXACT [OBOL:automatic]
xref: EMAPA:35664
xref: FMA:55569
xref: MA:0002677
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000353 ! parenchyma
intersection_of: UBERON:0000353 ! parenchyma
intersection_of: part_of UBERON:0001132 ! parathyroid gland
@@ -178471,7 +178564,6 @@ xref: MESH:D007765
xref: NCIT:C32905
xref: UMLS:C0022903 {source="ncithesaurus:Lacrimal_Apparatus"}
xref: Wikipedia:Lacrimal_apparatus
-is_a: CARO:0000006 ! material anatomical entity
is_a: UBERON:0000467 ! anatomical system
relationship: contributes_to_morphology_of UBERON:0000019 ! camera-type eye
relationship: develops_from UBERON:0000076 {source="ISBN:0781772214"} ! external ectoderm
@@ -178610,7 +178702,6 @@ xref: UMLS:C0011399 {source="ncithesaurus:Dental_Pulp"}
xref: VHOG:0001469
xref: Wikipedia:Dental_pulp
xref: ZFA:0005141
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0011825 {source="FMA"} ! loose connective tissue
relationship: develops_from UBERON:0001763 {source="ZFA"} ! odontogenic papilla
relationship: has_part CL:0000060 ! odontoblast
@@ -178679,7 +178770,6 @@ xref: SCTID:421159007
xref: UMLS:C0928075 {source="ncithesaurus:Auricle"}
xref: VHOG:0000460
xref: Wikipedia:Pinna_(anatomy)
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0001444 ! subdivision of head
relationship: continuous_with UBERON:0001352 ! external acoustic meatus
relationship: develops_from UBERON:0006208 ! auditory hillocks
@@ -178708,7 +178798,6 @@ xref: MESH:D010519
xref: NCIT:C33304
xref: UMLS:C0031093 {source="ncithesaurus:Periodontium"}
xref: Wikipedia:Periodontium
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000479 {source="cjm"} ! tissue
relationship: adjacent_to UBERON:0001091 ! calcareous tooth
relationship: has_part CL:0002166 {source="FMA"} ! epithelial cell of Malassez
@@ -178910,7 +178999,6 @@ xref: NCIT:C12811
xref: SCTID:280648000
xref: UMLS:C0042160 {source="ncithesaurus:Uvea"}
xref: Wikipedia:Uvea
-is_a: CARO:0000006 ! material anatomical entity
is_a: UBERON:0004923 {source="FMA"} ! organ component layer
relationship: contributes_to_morphology_of UBERON:0000019 ! camera-type eye
relationship: has_part UBERON:0001769 ! iris
@@ -179024,7 +179112,6 @@ xref: TAO:0002187
xref: UMLS:C0459875 {source="ncithesaurus:Corneal_Epithelium"}
xref: Wikipedia:Corneal_epithelium
xref: ZFA:0001683
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000488 {gci_relation="part_of", gci_filler="NCBITaxon:9606", source="FMA"} ! atypical epithelium
is_a: UBERON:0015808 ! eye epithelium
intersection_of: UBERON:0000483 ! epithelium
@@ -179064,7 +179151,6 @@ xref: VHOG:0001274
xref: Wikipedia:Sclera
xref: XAO:0000183
xref: ZFA:0005563
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000064 ! organ part
relationship: contributes_to_morphology_of UBERON:0000019 ! camera-type eye
relationship: develops_from UBERON:0003314 {source="ISBN:0781772214"} ! eye mesenchyme
@@ -179141,7 +179227,6 @@ xref: UMLS:C0008779 {source="ncithesaurus:Ciliary_Body"}
xref: VHOG:0000102
xref: Wikipedia:Ciliary_body
xref: XAO:0000186
-is_a: CARO:0000006 ! material anatomical entity
is_a: UBERON:0000481 ! multi-tissue structure
is_a: UBERON:0004121 ! ectoderm-derived structure
relationship: contributes_to_morphology_of UBERON:0011892 ! anterior uvea
@@ -179226,7 +179311,6 @@ xref: TAO:0002189
xref: UMLS:C0010040 {source="ncithesaurus:Corneal_Stroma"}
xref: Wikipedia:Corneal_stroma
xref: ZFA:0001685
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0003891 ! stroma
intersection_of: UBERON:0003891 ! stroma
intersection_of: part_of UBERON:0000964 ! cornea
@@ -179451,7 +179535,6 @@ xref: Wikipedia:Cranial_nerve
xref: XAO:0000429
xref: XAO:0003089
xref: ZFA:0000641
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0001021 ! nerve
is_a: UBERON:0034713 ! cranial neuron projection bundle
intersection_of: UBERON:0001021 ! nerve
@@ -179492,7 +179575,6 @@ xref: UMLS:C0016622 {source="ncithesaurus:Fovea_Centralis", source="BIRNLEX:2543
xref: UMLS:C0450290 {source="BIRNLEX:2543"}
xref: VHOG:0001572
xref: Wikipedia:Fovea_centralis_in_macula
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000064 ! organ part
relationship: has_part CHEBI:27547
relationship: has_part CHEBI:28838
@@ -179681,7 +179763,6 @@ xref: VHOG:0001167
xref: Wikipedia:Inner_nuclear_layer
xref: XAO:0003221
xref: ZFA:0000119
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0001781 ! layer of retina
relationship: adjacent_to UBERON:0001795 ! inner plexiform layer of retina
relationship: contributes_to_morphology_of UBERON:0003902 ! retinal neural layer
@@ -179728,7 +179809,6 @@ xref: VHOG:0001166
xref: Wikipedia:Ganglion_cell_layer
xref: XAO:0003223
xref: ZFA:0000024
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0001781 {source="FMA"} ! layer of retina
relationship: adjacent_to UBERON:0001793 ! nerve fiber layer of retina
relationship: composed_primarily_of CL:0000740 ! retinal ganglion cell
@@ -179804,7 +179884,6 @@ xref: UMLS:C1512783 {source="ncithesaurus:Inner_Limiting_Membrane"}
xref: Wikipedia:Inner_limiting_membrane
xref: XAO:0003222
xref: ZFA:0001029
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0007619 {source="MA"} ! limiting membrane of retina
relationship: adjacent_to UBERON:0001797 ! vitreous humor
relationship: has_part CL:0000127 ! astrocyte
@@ -180326,7 +180405,6 @@ xref: SCTID:181161008
xref: UMLS:C0009758 {source="ncithesaurus:Conjunctiva"}
xref: Wikipedia:Conjunctiva
xref: XAO:0000182
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000060 {source="FMA"} ! anatomical wall
relationship: adjacent_to UBERON:0001711 ! eyelid
relationship: adjacent_to UBERON:0001773 ! sclera
@@ -180382,7 +180460,7 @@ xref: SCTID:181002002
xref: UMLS:C0006090 {source="ncithesaurus:Brachial_Plexus"}
xref: VHOG:0000372
xref: Wikipedia:Brachial_plexus
-is_a: CARO:0001001 ! neuron projection bundle
+is_a: UBERON:0000122 ! neuron projection bundle
is_a: UBERON:0001813 ! spinal nerve plexus
relationship: innervates UBERON:0002102 ! forelimb
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
@@ -180414,7 +180492,7 @@ xref: SCTID:181049003
xref: UMLS:C0024093 {source="ncithesaurus:Lumbosacral_Plexus"}
xref: VHOG:0000926
xref: Wikipedia:Lumbosacral_plexus
-is_a: CARO:0001001 ! neuron projection bundle
+is_a: UBERON:0000122 ! neuron projection bundle
is_a: UBERON:0001813 ! spinal nerve plexus
relationship: innervates UBERON:0002103 ! hindlimb
property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/8/8d/Gray822.png" xsd:anyURI
@@ -180760,7 +180838,6 @@ xref: TAO:0001970
xref: VHOG:0001750
xref: Wikipedia:Upper_lip
xref: ZFA:0005226
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0001833 ! lip
intersection_of: UBERON:0001833 ! lip
intersection_of: part_of UBERON:0001709 ! upper jaw region
@@ -180791,7 +180868,6 @@ xref: TAO:0002060
xref: UMLS:C0458583 {source="ncithesaurus:Lower_Lip"}
xref: Wikipedia:Lower_lip
xref: ZFA:0005225
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0001833 ! lip
intersection_of: UBERON:0001833 ! lip
intersection_of: part_of UBERON:0001710 ! lower jaw region
@@ -180917,7 +180993,6 @@ xref: VHOG:0001144
xref: Wikipedia:Semicircular_canal
xref: XAO:0000198
xref: ZFA:0000431
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000025 {source="GO"} ! tube
relationship: develops_from UBERON:0003051 ! ear vesicle
relationship: part_of UBERON:0001849 {source="OG"} ! membranous labyrinth
@@ -181041,7 +181116,6 @@ xref: VHOG:0000284
xref: Wikipedia:Internal_ear
xref: XAO:0000192
xref: ZFA:0000217
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0034921 ! multi organ part structure
relationship: develops_from UBERON:0003051 {evidence="definitional"} ! ear vesicle
relationship: part_of UBERON:0001690 ! ear
@@ -181805,7 +181879,6 @@ xref: SCTID:280344009
xref: UMLS:C0031774 {source="ncithesaurus:Phrenic_Nerve"}
xref: VHOG:0000728
xref: Wikipedia:Phrenic_nerve
-is_a: CARO:0001001 ! neuron projection bundle
is_a: UBERON:0003443 ! thoracic cavity nerve
intersection_of: UBERON:0001021 ! nerve
intersection_of: innervates UBERON:0001103 ! diaphragm
@@ -182693,7 +182766,6 @@ xref: VHOG:0001164
xref: Wikipedia:Optic_tract
xref: XAO:0004101
xref: ZFA:0000252
-is_a: CARO:0001001 ! neuron projection bundle
is_a: UBERON:0011591 ! tract of diencephalon
relationship: contributes_to_morphology_of UBERON:0003544 ! brain white matter
relationship: extends_fibers_into UBERON:0000941 ! cranial nerve II
@@ -183348,7 +183420,6 @@ xref: FMA:62498
xref: MA:0001773
xref: NCIT:C48943
xref: UMLS:C1179179 {source="ncithesaurus:Respiratory_Bronchiole_Epithelium"}
-is_a: CARO:0000006 ! material anatomical entity
is_a: UBERON:0002051 ! epithelium of bronchiole
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0002188 ! respiratory bronchiole
@@ -183430,7 +183501,6 @@ xref: FMA:62794
xref: MA:0001774
xref: NCIT:C33755
xref: UMLS:C1179400 {source="ncithesaurus:Terminal_Bronchiole_Epithelium"}
-is_a: CARO:0000006 ! material anatomical entity
is_a: UBERON:0002051 ! epithelium of bronchiole
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0002187 ! terminal bronchiole
@@ -183459,7 +183529,6 @@ xref: MA:0000762
xref: NCIT:C12993
xref: UMLS:C0229686 {source="ncithesaurus:Splenic_White_Pulp"}
xref: Wikipedia:White_pulp
-is_a: CARO:0000000 ! anatomical entity
is_a: PR:000050567 ! protein-containing material entity
is_a: UBERON:1000023 ! spleen pulp
relationship: composed_primarily_of CL:0000542 ! lymphocyte
@@ -183584,7 +183653,6 @@ xref: NCIT:C13713
xref: UMLS:C1518159 {source="ncithesaurus:Male_Genital_System_Fluid_or_Secretion"}
xref: UMLS:C2756969 {source="ncithesaurus:Semen"}
xref: Wikipedia:Semen
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000463 ! organism substance
relationship: has_part CL:0000019 ! sperm
relationship: has_part UBERON:0006530 ! seminal fluid
@@ -183940,7 +184008,6 @@ xref: VHOG:0001250
xref: Wikipedia:Blood_vessel
xref: XAO:0001011
xref: ZFA:0005314
-is_a: CARO:0000000 ! anatomical entity
is_a: PR:000050567 ! protein-containing material entity
is_a: UBERON:0000055 ! vessel
relationship: capable_of_part_of GO:0008015 ! blood circulation
@@ -184252,7 +184319,6 @@ xref: NCIT:C94819
xref: UMLS:C0221930 {source="ncithesaurus:Stratum_Papillare"}
xref: UMLS:C0682598 {source="ncithesaurus:Papillary_Dermis"}
xref: Wikipedia:Papillary_dermis
-is_a: CARO:0000000 ! anatomical entity
is_a: PR:000050567 ! protein-containing material entity
is_a: UBERON:0013754 ! integumentary system layer
relationship: composed_primarily_of UBERON:0006815 {source="WP"} ! areolar connective tissue
@@ -184490,7 +184556,6 @@ xref: TAO:0001155
xref: UMLS:C0206111 {source="BIRNLEX:1166"}
xref: Wikipedia:Enteric_nervous_system
xref: ZFA:0001155
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0011216 {source="cjm"} ! organ system subdivision
relationship: contributes_to_morphology_of UBERON:0002410 ! autonomic nervous system
relationship: develops_from UBERON:0005428 {source="Wikipedia", source="ZFA", source="https://github.com/obophenotype/uberon/wiki/The-neural-crest"} ! vagal neural crest
@@ -184561,7 +184626,7 @@ xref: NCIT:C52833
xref: SCTID:280511002
xref: UMLS:C0459528 {source="ncithesaurus:Cardiac_Nerve_Plexus"}
xref: Wikipedia:Cardiac_plexus
-is_a: CARO:0001001 ! neuron projection bundle
+is_a: UBERON:0000122 ! neuron projection bundle
is_a: UBERON:0001816 ! autonomic nerve plexus
intersection_of: UBERON:0001816 ! autonomic nerve plexus
intersection_of: innervates UBERON:0000948 ! heart
@@ -184776,7 +184841,6 @@ xref: SCTID:361828005
xref: UMLS:C0039099 {source="ncithesaurus:Synovial_Membrane"}
xref: VHOG:0001282
xref: Wikipedia:Synovial_membrane
-is_a: CARO:0010000 ! multicellular anatomical structure
is_a: UBERON:0006915 ! stratified squamous epithelium
is_a: UBERON:0007616 {source="FMA"} ! layer of synovial tissue
is_a: UBERON:0012275 ! meso-epithelium
@@ -184923,7 +184987,6 @@ xref: UMLS:C0221925 {source="ncithesaurus:Stratum_Basale"}
xref: Wikipedia:Stratum_germinativum
xref: XAO:0000041
xref: ZFA:0001180
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0013754 ! integumentary system layer
intersection_of: UBERON:0013754 ! integumentary system layer
intersection_of: composed_primarily_of CL:0002187 ! basal cell of epidermis
@@ -184958,7 +185021,6 @@ xref: NCIT:C12850
xref: SCTID:420086000
xref: UMLS:C0221924 {source="ncithesaurus:Stratum_Spinosum"}
xref: Wikipedia:Stratum_spinosum
-is_a: CARO:0000006 ! material anatomical entity
is_a: PR:000050567 ! protein-containing material entity
is_a: UBERON:0013754 ! integumentary system layer
intersection_of: UBERON:0013754 ! integumentary system layer
@@ -185157,7 +185219,6 @@ xref: FMA:67782
xref: MA:0001839
xref: NCIT:C32231
xref: UMLS:C0599333 {source="ncithesaurus:Bronchial_Epithelium"}
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0008397 ! tracheobronchial epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0002185 ! bronchus
@@ -185189,7 +185250,6 @@ xref: FMA:67821
xref: MA:0000778
xref: SCTID:319910005
xref: Wikipedia:Arrector_pili_muscle
-is_a: CARO:0010000 ! multicellular anatomical structure
is_a: UBERON:0001135 {source="FMA"} ! smooth muscle tissue
relationship: attaches_to UBERON:0002073 ! hair follicle
relationship: part_of UBERON:0011932 {source="FMA"} ! pilosebaceous unit
@@ -185357,6 +185417,8 @@ is_a: UBERON:0004573 ! systemic artery
intersection_of: UBERON:0004573 ! systemic artery
intersection_of: part_of UBERON:0004571 ! systemic arterial system
intersection_of: supplies UBERON:0002048 ! lung
+relationship: has_part UBERON:0004848 ! respiratory system arterial endothelium
+relationship: has_part UBERON:0012416 ! respiratory system arterial smooth muscle
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: supplies UBERON:0002048 ! lung
property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/a/a7/Gray1032.png" xsd:anyURI
@@ -185661,7 +185723,6 @@ xref: MA:0001891
xref: MESH:D015384
xref: SCTID:21476003
xref: Wikipedia:Zona_glomerulosa
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0009753 {source="MA"} ! adrenal gland cortex zone
relationship: capable_of GO:0032342 ! aldosterone biosynthetic process
relationship: contributes_to_morphology_of UBERON:0001235 ! adrenal cortex
@@ -185935,7 +185996,6 @@ xref: NCIT:C33627
xref: SCTID:418563001
xref: UMLS:C0221923 {source="ncithesaurus:Stratum_Granulosum"}
xref: Wikipedia:Stratum_granulosum
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0013754 ! integumentary system layer
intersection_of: UBERON:0013754 ! integumentary system layer
intersection_of: composed_primarily_of CL:0000712 ! stratum granulosum cell
@@ -186428,7 +186488,6 @@ xref: VHOG:0000317
xref: VSAO:0000093
xref: XAO:0003073
xref: ZFA:0000317
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0010912 ! subdivision of skeleton
relationship: develops_from UBERON:0003089 ! sclerotome
relationship: part_of UBERON:0005944 ! axial skeleton plus cranial skeleton
@@ -187343,7 +187402,6 @@ xref: SCTID:181248002
xref: UMLS:C0022378 {source="ncithesaurus:Jejunum"}
xref: VHOG:0000053
xref: Wikipedia:Jejunum
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0004921 {order="3", source="cjm"} ! subdivision of digestive tract
relationship: contributes_to_morphology_of UBERON:0002108 ! small intestine
relationship: develops_from UBERON:0001045 {source="Wikipedia"} ! midgut
@@ -187514,7 +187572,6 @@ xref: NCIT:C33774
xref: SCTID:188262003
xref: UMLS:C0229948 {source="ncithesaurus:Thymus_Cortex"}
xref: Wikipedia:Thymus#Cortex
-is_a: CARO:0000000 ! anatomical entity
is_a: PR:000050567 ! protein-containing material entity
is_a: UBERON:0001851 ! cortex
intersection_of: UBERON:0001851 ! cortex
@@ -187569,7 +187626,6 @@ xref: MA:0000770
xref: NCIT:C33772
xref: SCTID:187882006
xref: UMLS:C1522462 {source="ncithesaurus:Thymic_Lobule"}
-is_a: CARO:0000000 ! anatomical entity
is_a: PR:000050567 ! protein-containing material entity
is_a: UBERON:0009911 ! lobule
intersection_of: UBERON:0009911 ! lobule
@@ -188044,6 +188100,9 @@ xref: UMLS:C0225653 {source="ncithesaurus:Lobar_Bronchus"}
xref: Wikipedia:Secondary_bronchus
is_a: UBERON:0035767 ! intrapulmonary bronchus
relationship: distally_connected_to UBERON:0002184 ! segmental bronchus
+relationship: has_part UBERON:0001956 ! cartilage of bronchus
+relationship: has_part UBERON:0004242 ! bronchus smooth muscle
+relationship: has_part UBERON:8410043 ! bronchus submucosal gland
relationship: part_of UBERON:0000101 {source="FMA"} ! lobe of lung
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/d/df/Illu_quiz_lung05.jpg" xsd:anyURI
@@ -188072,6 +188131,10 @@ xref: UMLS:C0444439 {source="ncithesaurus:Segmental_Bronchus"}
xref: VHOG:0001446
xref: Wikipedia:Segmental_bronchus
is_a: UBERON:0035767 ! intrapulmonary bronchus
+relationship: has_part UBERON:0001956 ! cartilage of bronchus
+relationship: has_part UBERON:0004242 ! bronchus smooth muscle
+relationship: has_part UBERON:0004883 ! lung mesenchyme
+relationship: has_part UBERON:8410043 ! bronchus submucosal gland
relationship: part_of UBERON:0000101 {source="FMA"} ! lobe of lung
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: proximally_connected_to UBERON:0002183 ! lobar bronchus
@@ -188453,7 +188516,6 @@ xref: TAO:0000368
xref: VSAO:0000029
xref: Wikipedia:Integument
xref: ZFA:0000368
-is_a: CARO:0000006 ! material anatomical entity
is_a: PR:000050567 ! protein-containing material entity
is_a: UBERON:0011216 {source="FMA"} ! organ system subdivision
relationship: bounding_layer_of UBERON:0000468 ! multicellular organism
@@ -188557,7 +188619,6 @@ xref: FMA:74743
xref: SCTID:123846009
xref: TAO:0007057
xref: ZFA:0007057
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0002200 ! vasculature of head
is_a: UBERON:0006876 ! vasculature of organ
intersection_of: UBERON:0002049 ! vasculature
@@ -188589,7 +188650,6 @@ xref: VHOG:0001275
xref: VSAO:0000031
xref: Wikipedia:Musculoskeletal_system
xref: XAO:0000168
-is_a: CARO:0000006 ! material anatomical entity
is_a: UBERON:0000467 ! anatomical system
disjoint_from: UBERON:0002294 ! biliary system
disjoint_from: UBERON:0002330 ! exocrine system
@@ -188767,7 +188827,6 @@ xref: SCTID:58442004
xref: TAO:0005155
xref: Wikipedia:Cartilaginous_joint
xref: ZFA:0005155
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0011134 {source="FMA"} ! nonsynovial joint
intersection_of: UBERON:0011134 ! nonsynovial joint
intersection_of: composed_primarily_of UBERON:0002418 ! cartilage tissue
@@ -189700,7 +189759,6 @@ xref: UMLS:C0152279 {source="ncithesaurus:Lateral_Ventricle", source="BIRNLEX:12
xref: VHOG:0000643
xref: Wikipedia:Lateral_ventricle
xref: ZFA:0000696
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0004086 ! brain ventricle
intersection_of: UBERON:0004086 ! brain ventricle
intersection_of: part_of UBERON:0001893 ! telencephalon
@@ -189809,7 +189867,6 @@ xref: MESH:D001659
xref: NCIT:C12678
xref: SCTID:361354009
xref: Wikipedia:Biliary_system
-is_a: CARO:0000006 ! material anatomical entity
is_a: PR:000050567 ! protein-containing material entity
is_a: UBERON:0011216 ! organ system subdivision
intersection_of: UBERON:0011216 ! organ system subdivision
@@ -190033,7 +190090,6 @@ xref: NCIT:C32891
xref: SCTID:362219002
xref: UMLS:C0022445 {source="ncithesaurus:Juxtaglomerular_Apparatus"}
xref: Wikipedia:Juxtaglomerular_apparatus
-is_a: CARO:0000000 ! anatomical entity
is_a: PR:000050567 ! protein-containing material entity
is_a: UBERON:0000061 ! anatomical structure
relationship: capable_of GO:0003093 {source="GO"} ! regulation of glomerular filtration
@@ -190386,7 +190442,6 @@ xref: MA:0002617
xref: NCIT:C33101
xref: UMLS:C0017655 {source="ncithesaurus:Mesangium"}
xref: Wikipedia:Mesangium
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000119 ! cell layer
intersection_of: UBERON:0000119 ! cell layer
intersection_of: composed_primarily_of CL:0000650 ! mesangial cell
@@ -190483,7 +190538,6 @@ xref: SCTID:361348008
xref: TAO:0001438
xref: UMLS:C0333343 {source="ncithesaurus:Cavity"}
xref: ZFA:0001438
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0002553 ! anatomical cavity
relationship: luminal_space_of UBERON:0011997 ! coelom
relationship: transformation_of UBERON:0003886 {evidence="definitional"} ! future coelemic cavity lumen
@@ -190658,7 +190712,6 @@ xref: VHOG:0000191
xref: Wikipedia:Somite
xref: XAO:0000058
xref: ZFA:0000155
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0005423 ! developing anatomical structure
is_a: UBERON:0007503 {source="EHDAA2"} ! epithelial vesicle
relationship: develops_from UBERON:0003059 {source="ZFA"} ! presomitic mesoderm
@@ -190735,7 +190788,6 @@ xref: NCIT:C34320
xref: SCTID:280644003
xref: UMLS:C0041633 {source="ncithesaurus:Umbilical_Cord"}
xref: Wikipedia:Umbilical_cord
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000478 ! extraembryonic structure
relationship: connects UBERON:0000922 ! embryo
relationship: connects UBERON:0001987 ! placenta
@@ -191086,7 +191138,6 @@ xref: VHOG:0000119
xref: Wikipedia:Epicardium
xref: XAO:0000316
xref: ZFA:0005057
-is_a: CARO:0010000 ! multicellular anatomical structure
is_a: UBERON:0000481 ! multi-tissue structure
relationship: attaches_to UBERON:0002349 {source="FMA"} ! myocardium
relationship: develops_from UBERON:0004160 ! proepicardium
@@ -191375,7 +191426,6 @@ xref: NCIT:C12767
xref: SCTID:229765004
xref: UMLS:C0030797 {source="ncithesaurus:Pelvis"}
xref: Wikipedia:Pelvis
-is_a: CARO:0000006 ! material anatomical entity
is_a: UBERON:0000475 ! organism subdivision
relationship: has_part UBERON:0007832 ! pelvic girdle skeleton
relationship: part_of UBERON:0002417 ! abdominal segment of trunk
@@ -191395,7 +191445,6 @@ xref: FMA:9582
xref: MA:0002739
xref: SCTID:243954002
xref: Wikipedia:Serous_pericardium
-is_a: CARO:0010000 ! multicellular anatomical structure
is_a: UBERON:0000042 ! serous membrane
relationship: attaches_to UBERON:0002359 {source="FMA"} ! fibrous pericardium
relationship: has_part UBERON:0002408 ! parietal serous pericardium
@@ -192399,7 +192448,6 @@ xref: VHOG:0001624
xref: Wikipedia:Haematopoiesis
xref: XAO:0000122
xref: ZFA:0005023
-is_a: CARO:0000006 ! material anatomical entity
is_a: UBERON:0000467 ! anatomical system
is_a: UBERON:0004120 ! mesoderm-derived structure
disjoint_from: UBERON:0002405 ! immune system
@@ -192441,7 +192489,6 @@ xref: UMLS:C0024202 {source="ncithesaurus:Lymph"}
xref: VHOG:0001590
xref: Wikipedia:Lymph
xref: ZFA:0005658
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000179 ! haemolymphatic fluid
relationship: part_of UBERON:0006558 ! lymphatic part of lymphoid system
relationship: transformation_of UBERON:0000913 ! interstitial fluid
@@ -192471,7 +192518,6 @@ xref: SCTID:280643009
xref: UMLS:C0027437 {source="ncithesaurus:Nasolacrimal_Duct"}
xref: VHOG:0000664
xref: Wikipedia:Nasolacrimal_duct
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000025 ! tube
is_a: UBERON:0000058 ! duct
relationship: channel_for UBERON:0001827 ! secretion of lacrimal gland
@@ -192629,7 +192675,6 @@ xref: SCTID:361998003
xref: UMLS:C0225777 {source="ncithesaurus:Parietal_Pleura"}
xref: VHOG:0001495
xref: Wikipedia:Parietal_pleura
-is_a: CARO:0010000 ! multicellular anatomical structure
is_a: UBERON:0004923 ! organ component layer
intersection_of: UBERON:0004923 ! organ component layer
intersection_of: adjacent_to UBERON:0002224 ! thoracic cavity
@@ -192662,7 +192707,6 @@ xref: NCIT:C33881
xref: SCTID:361997008
xref: UMLS:C0225776 {source="ncithesaurus:Visceral_Pleura"}
xref: VHOG:0001496
-is_a: CARO:0010000 ! multicellular anatomical structure
is_a: UBERON:0022350 ! visceral serous membrane
intersection_of: UBERON:0004923 ! organ component layer
intersection_of: adjacent_to UBERON:0002048 ! lung
@@ -192699,7 +192743,6 @@ xref: SCTID:361999006
xref: UMLS:C0178802 {source="ncithesaurus:Pleural_Cavity"}
xref: VHOG:0000581
xref: Wikipedia:Pleural_cavity
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0035809 ! serous cavity
intersection_of: UBERON:0002553 ! anatomical cavity
intersection_of: luminal_space_of UBERON:0009778 ! pleural sac
@@ -192802,7 +192845,6 @@ xref: VHOG:0001280
xref: Wikipedia:Pericardium
xref: XAO:0004182
xref: ZFA:0000054
-is_a: CARO:0000006 ! material anatomical entity
is_a: PR:000050567 ! protein-containing material entity
is_a: UBERON:0000481 ! multi-tissue structure
relationship: has_part UBERON:0002359 ! fibrous pericardium
@@ -193077,7 +193119,6 @@ xref: UMLS:C0037267 {source="ncithesaurus:Integumentary_System"}
xref: VHOG:0000403
xref: Wikipedia:Integumentary_system
xref: XAO:0000176
-is_a: CARO:0000006 ! material anatomical entity
is_a: PR:000050567 ! protein-containing material entity
is_a: UBERON:0000467 ! anatomical system
disjoint_from: UBERON:0002423 ! hepatobiliary system
@@ -193290,7 +193331,6 @@ xref: VHOG:0000006
xref: Wikipedia:Fourth_ventricle
xref: XAO:0003099
xref: ZFA:0000110
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0004086 ! brain ventricle
intersection_of: UBERON:0004086 ! brain ventricle
intersection_of: part_of UBERON:0002028 ! hindbrain
@@ -193333,7 +193373,6 @@ xref: VHOG:0000294
xref: Wikipedia:Hepatobiliary_system
xref: XAO:0000132
xref: ZFA:0000036
-is_a: CARO:0000006 ! material anatomical entity
is_a: PR:000050567 ! protein-containing material entity
is_a: UBERON:0011216 ! organ system subdivision
disjoint_from: UBERON:0004456 ! entire sense organ system
@@ -193402,7 +193441,6 @@ xref: MA:0000484
xref: SCTID:243955001
xref: VHOG:0000538
xref: Wikipedia:Visceral_pericardium
-is_a: CARO:0010000 ! multicellular anatomical structure
is_a: UBERON:0022350 ! visceral serous membrane
intersection_of: UBERON:0022350 ! visceral serous membrane
intersection_of: part_of UBERON:0002357 ! serous pericardium
@@ -193727,7 +193765,6 @@ xref: NCIT:C32425
xref: SCTID:362842004
xref: UMLS:C0011106 {source="ncithesaurus:Decidua"}
xref: Wikipedia:Decidua
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000478 {source="FMA"} ! extraembryonic structure
relationship: contributes_to_morphology_of UBERON:0001987 ! placenta
relationship: develops_from UBERON:0000459 ! uterine wall
@@ -194026,7 +194063,6 @@ xref: MIAA:0000091
xref: NCIT:C77660
xref: SCTID:95936004
xref: UMLS:C0687080 {source="ncithesaurus:Paw"}
-is_a: CARO:0010000 ! multicellular anatomical structure
is_a: UBERON:0002529 ! limb segment
intersection_of: UBERON:0002529 ! limb segment
intersection_of: has_skeleton UBERON:0006717 ! autopodial skeleton
@@ -194060,7 +194096,6 @@ xref: FMA:83016
xref: MA:0002716
xref: MAT:0000092
xref: MIAA:0000092
-is_a: CARO:0010000 ! multicellular anatomical structure
is_a: UBERON:0002529 ! limb segment
intersection_of: UBERON:0002529 ! limb segment
intersection_of: has_skeleton UBERON:0011584 ! zeugopodial skeleton
@@ -194087,7 +194122,6 @@ xref: FMA:83014
xref: MA:0002717
xref: MAT:0000093
xref: MIAA:0000093
-is_a: CARO:0010000 ! multicellular anatomical structure
is_a: UBERON:0002529 ! limb segment
intersection_of: UBERON:0002529 ! limb segment
intersection_of: has_skeleton UBERON:0011583 ! stylopodial skeleton
@@ -194487,7 +194521,6 @@ xref: FMA:7269
xref: MA:0002831
xref: SCTID:118755002
xref: Wikipedia:Trabeculae_carneae
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000440 ! trabecula
relationship: composed_primarily_of UBERON:0001133 ! cardiac muscle tissue
relationship: part_of UBERON:0002082 {source="WP"} ! cardiac ventricle
@@ -194701,7 +194734,6 @@ xref: NCIT:C33821
xref: SCTID:61695000
xref: UMLS:C0162867 {source="ncithesaurus:Tunica_Media"}
xref: Wikipedia:Tunica_media
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0004797 {source="MA"} ! blood vessel layer
relationship: has_part UBERON:0002521 {source="cjm"} ! elastic tissue
relationship: has_part UBERON:0004237 {source="cjm"} ! blood vessel smooth muscle
@@ -194728,7 +194760,6 @@ xref: SCTID:8361002
xref: SCTID:87483006
xref: UMLS:C0162864 {source="ncithesaurus:Tunica_Intima"}
xref: Wikipedia:Tunica_intima
-is_a: CARO:0000000 ! anatomical entity
is_a: PR:000050567 ! protein-containing material entity
is_a: UBERON:0004923 {source="FMA"} ! organ component layer
relationship: adjacent_to UBERON:0010161 {source="ISBN:0073040584"} ! lumen of blood vessel
@@ -194774,7 +194805,6 @@ xref: FMA:241863
xref: MA:0002889
xref: NCIT:C38630
xref: UMLS:C1268195 {source="ncithesaurus:Extremity_Part"}
-is_a: CARO:0000006 ! material anatomical entity
is_a: UBERON:0010538 ! paired limb/fin segment
intersection_of: UBERON:0010758 ! subdivision of organism along appendicular axis
intersection_of: part_of UBERON:0002101 ! limb
@@ -194961,7 +194991,6 @@ xref: VHOG:0000155
xref: Wikipedia:Pharyngeal_arch
xref: XAO:0000096
xref: ZFA:0001306
-is_a: CARO:0000006 ! material anatomical entity
is_a: UBERON:0000481 ! multi-tissue structure
is_a: UBERON:0010188 {source="EHDAA2"} ! protuberance
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
@@ -194996,7 +195025,6 @@ xref: VHOG:0001243
xref: Wikipedia:Lateral_line_system
xref: XAO:0000095
xref: ZFA:0000034
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0001032 ! sensory system
relationship: has_part UBERON:0010202 ! lateral line
relationship: never_in_taxon NCBITaxon:32524 {source="http://tolweb.org/Amniota"} ! Amniota
@@ -195282,7 +195310,6 @@ xref: FMA:55676
xref: NCIT:C13031
xref: SCTID:384763002
xref: UMLS:C0445620 {source="ncithesaurus:Brain_Part"}
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000073 ! regional part of nervous system
intersection_of: UBERON:0000481 ! multi-tissue structure
intersection_of: part_of UBERON:0000955 ! brain
@@ -196233,7 +196260,6 @@ xref: MBA:1143
xref: NCIT:C49138
xref: neuronames:363 {source="BIRNLEX:779"}
xref: UMLS:C1708253 {source="ncithesaurus:Granular_Layer_of_the_Cerebellum"}
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0004130 ! cerebellar layer
intersection_of: UBERON:0004130 ! cerebellar layer
intersection_of: in_deep_part_of UBERON:0002129 ! cerebellar cortex
@@ -196268,7 +196294,6 @@ xref: SCTID:369045002
xref: UMLS:C0228469 {source="BIRNLEX:810"}
xref: UMLS:C1289474 {source="BIRNLEX:810"}
xref: UMLS:C1709064 {source="ncithesaurus:Molecular_Layer_of_the_Cerebellum"}
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0004130 ! cerebellar layer
intersection_of: UBERON:0004130 ! cerebellar layer
intersection_of: in_superficial_part_of UBERON:0002129 ! cerebellar cortex
@@ -196306,7 +196331,6 @@ xref: SCTID:369046001
xref: UMLS:C0228469 {source="BIRNLEX:818"}
xref: UMLS:C1289475 {source="BIRNLEX:818"}
xref: UMLS:C1709776 {source="ncithesaurus:Purkinje_Cell_Layer_of_the_Cerebellum"}
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0004130 ! cerebellar layer
intersection_of: UBERON:0004130 ! cerebellar layer
intersection_of: immediately_deep_to UBERON:0002974 ! molecular layer of cerebellar cortex
@@ -196341,7 +196365,6 @@ xref: neuronames:557 {source="BIRNLEX:923"}
xref: SCTID:362401009
xref: UMLS:C0228426 {source="BIRNLEX:923"}
xref: Wikipedia:Pontine_tegmentum
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000064 ! organ part
relationship: has_part UBERON:0002047 ! pontine raphe nucleus
relationship: has_part UBERON:0002128 ! superior olivary complex
@@ -196547,7 +196570,6 @@ xref: UMLS:C1518973 {source="ncithesaurus:Periderm"}
xref: VHOG:0001680
xref: XAO:0000029
xref: ZFA:0001185
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000487 {source="EHDAA2"} ! simple squamous epithelium
relationship: develops_from UBERON:0007383 {source="ZFA"} ! enveloping layer of ectoderm
relationship: part_of UBERON:0002199 {source="EHDAA2"} ! integument
@@ -196704,7 +196726,6 @@ xref: VHOG:0000086
xref: Wikipedia:Prechordal_plate
xref: XAO:0000079
xref: ZFA:0000060
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0002050 ! embryonic structure
relationship: part_of UBERON:0003068 {source="ZFA"} ! axial mesoderm
relationship: transformation_of UBERON:0034878 {todo="PMID:16313393"} ! prechordal mesoderm
@@ -196738,7 +196759,6 @@ xref: VHOG:0000087
xref: Wikipedia:Intermediate_mesoderm
xref: XAO:0000085
xref: ZFA:0001206
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0002050 ! embryonic structure
relationship: adjacent_to UBERON:0003077 ! paraxial mesoderm
relationship: adjacent_to UBERON:0003081 ! lateral plate mesoderm
@@ -196820,7 +196840,6 @@ xref: VHOG:0000107
xref: Wikipedia:Chordamesoderm
xref: XAO:0000205
xref: ZFA:0001204
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0002050 ! embryonic structure
relationship: develops_from UBERON:0000926 ! mesoderm
relationship: only_in_taxon NCBITaxon:7711 ! Chordata
@@ -196942,7 +196961,6 @@ xref: TAO:0001202
xref: UMLS:C0231109 {source="ncithesaurus:Optic_Cup"}
xref: VHOG:0000167
xref: ZFA:0001202
-is_a: CARO:0000006 ! material anatomical entity
is_a: UBERON:0000481 ! multi-tissue structure
is_a: UBERON:0004121 ! ectoderm-derived structure
relationship: developmentally_induced_by UBERON:0003073 ! lens placode
@@ -196974,7 +196992,6 @@ xref: VHOG:0000166
xref: Wikipedia:Lens_placode
xref: XAO:0000240
xref: ZFA:0000122
-is_a: CARO:0000006 ! material anatomical entity
is_a: UBERON:0002546 ! cranial placode
is_a: UBERON:0006598 ! presumptive structure
is_a: UBERON:0011814 {source="NCBIBook:NBK53175"} ! non-neurogenic ectodermal placode
@@ -197056,7 +197073,6 @@ xref: VHOG:0000068
xref: Wikipedia:Neural_plate
xref: XAO:0000249
xref: ZFA:0000132
-is_a: CARO:0000006 ! material anatomical entity
is_a: UBERON:0005291 ! embryonic tissue
is_a: UBERON:0010371 ! ecto-epithelium
is_a: UBERON:0016879 ! future central nervous system
@@ -197076,7 +197092,6 @@ xref: TAO:0007037
xref: VHOG:0001383
xref: XAO:0000250
xref: ZFA:0007037
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0002050 ! embryonic structure
disjoint_from: UBERON:0003080 {source="lexical"} ! anterior neural tube
relationship: develops_from UBERON:0003057 ! chordal neural plate
@@ -197151,7 +197166,6 @@ xref: TAO:0007038
xref: VHOG:0001384
xref: XAO:0000307
xref: ZFA:0007038
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0002050 ! embryonic structure
relationship: develops_from UBERON:0003056 ! pre-chordal neural plate
relationship: part_of UBERON:0001049 ! neural tube
@@ -197229,7 +197243,6 @@ xref: VHOG:0001244
xref: Wikipedia:Myotome
xref: XAO:0000315
xref: ZFA:0001056
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0017650 {source="AEO"} ! developing mesenchymal structure
relationship: contributes_to_morphology_of UBERON:0001630 ! muscle organ
relationship: develops_from UBERON:0004290 {source="EHDAA2-abduced"} ! dermomyotome
@@ -197255,7 +197268,6 @@ xref: VHOG:0000062
xref: Wikipedia:Trunk_neural_crest
xref: XAO:0000319
xref: ZFA:0001024
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0005291 ! embryonic tissue
relationship: has_part CL:0000011 {source="ZFA"} ! migratory trunk neural crest cell
relationship: part_of UBERON:0002342 ! neural crest
@@ -197277,7 +197289,6 @@ xref: TAO:0000028
xref: UMLS:C1514450 {source="ncithesaurus:Primordium_of_the_Heart"}
xref: XAO:0000336
xref: ZFA:0000028
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0001048 {source="Obol"} ! primordium
relationship: develops_from UBERON:0003081 {source="ZFA"} ! lateral plate mesoderm
relationship: develops_from UBERON:0004140 ! primary heart field
@@ -197426,7 +197437,6 @@ xref: VHOG:0000063
xref: Wikipedia:Cranial_neural_crest
xref: XAO:0001001
xref: ZFA:0001194
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0005291 ! embryonic tissue
relationship: has_part CL:0000008 ! migratory cranial neural crest cell
relationship: part_of UBERON:0002342 ! neural crest
@@ -198005,7 +198015,6 @@ xref: UMLS:C0008503 {source="ncithesaurus:Chorion"}
xref: UMLS:C1516505 {source="ncithesaurus:Chorionic_Sac"}
xref: VHOG:0000200
xref: Wikipedia:Chorion
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0005631 ! extraembryonic membrane
relationship: adjacent_to UBERON:0000922 ! embryo
relationship: develops_from UBERON:0005971 {source="ISBN:0073040584"} ! amniotic fold
@@ -198055,7 +198064,6 @@ xref: UMLS:C0040578 {source="ncithesaurus:Trachea"}
xref: VHOG:0000371
xref: Wikipedia:Vertebrate_trachea
xref: XAO:0000118
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000117 ! respiratory tube
relationship: contributes_to_morphology_of UBERON:0001004 ! respiratory system
relationship: develops_from UBERON:0008947 {source="EHDAA2"} ! respiratory primordium
@@ -198352,7 +198360,6 @@ xref: EMAPA:17375
xref: SCTID:361529008
xref: VHOG:0000540
xref: Wikipedia:Metanephric_blastema
-is_a: CARO:0000006 ! material anatomical entity
is_a: UBERON:0003918 ! kidney mesenchyme
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0005291 ! embryonic tissue
@@ -198413,7 +198420,6 @@ xref: EHDAA:4168
xref: EHDAA:6214
xref: EMAPA:17415
xref: VHOG:0001044
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000483 ! epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0001461 ! elbow
@@ -198434,7 +198440,6 @@ synonym: "wrist epithelial tissue" EXACT [OBOL:automatic]
synonym: "wrist epithelium" EXACT [OBOL:automatic]
xref: EHDAA2:0000219
xref: EHDAA:5198
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000490 {source="EHDAA2"} ! unilaminar epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0004452 ! carpal region
@@ -198462,7 +198467,6 @@ xref: EHDAA:5155
xref: EHDAA:6180
xref: EMAPA:17491
xref: VHOG:0000779
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000483 ! epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0001464 ! hip
@@ -198482,7 +198486,6 @@ xref: EHDAA:5161
xref: EHDAA:6186
xref: EMAPA:17494
xref: VHOG:0000810
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000483 ! epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0001465 ! knee
@@ -198502,7 +198505,6 @@ xref: EHDAA:4182
xref: EHDAA:6230
xref: EMAPA:17422
xref: VHOG:0000761
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000483 ! epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0001467 ! shoulder
@@ -198582,7 +198584,6 @@ xref: FMA:75604
xref: MA:0001204
xref: RETIRED_EHDAA2:0002155
xref: VHOG:0000634
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0006932 {source="FMA"} ! vestibular epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0001853 ! utricle of membranous labyrinth
@@ -198619,7 +198620,6 @@ xref: FMA:75605
xref: MA:0001202
xref: RETIRED_EHDAA2:0001771
xref: VHOG:0000633
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0006932 ! vestibular epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0001854 ! saccule of membranous labyrinth
@@ -198675,7 +198675,6 @@ xref: MA:0000792
xref: NCIT:C12937
xref: UMLS:C0596882 {source="ncithesaurus:Mammary_Epithelium"}
xref: VHOG:0001088
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000483 ! epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0001911 ! mammary gland
@@ -198695,7 +198694,6 @@ xref: EHDAA:4174
xref: EHDAA:6220
xref: EMAPA:17418
xref: VHOG:0001096
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000483 ! epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0002386 ! forelimb zeugopod
@@ -198713,7 +198711,6 @@ xref: EHDAA2:0000548
xref: EHDAA:5145
xref: EHDAA:6144
xref: EMAPA:32655
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000490 {source="EHDAA2"} ! unilaminar epithelium
is_a: UBERON:0005291 ! embryonic tissue
intersection_of: UBERON:0000483 ! epithelium
@@ -198796,7 +198793,6 @@ xref: EHDAA2:0000117
xref: EHDAA:138
xref: EMAPA:16110
xref: VHOG:0000621
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000478 {source="EHDAA2"} ! extraembryonic structure
is_a: UBERON:0000490 {source="EHDAA2"} ! unilaminar epithelium
is_a: UBERON:0005292 ! extraembryonic tissue
@@ -199025,7 +199021,6 @@ xref: FMA:54397
xref: MA:0001908
xref: VHOG:0000429
xref: XAO:0003087
-is_a: CARO:0010000 ! multicellular anatomical structure
is_a: UBERON:0010912 ! subdivision of skeleton
intersection_of: UBERON:0010912 ! subdivision of skeleton
intersection_of: skeleton_of UBERON:0001709 ! upper jaw region
@@ -199057,7 +199052,6 @@ xref: TAO:0001273
xref: VHOG:0000428
xref: XAO:0003084
xref: ZFA:0001273
-is_a: CARO:0010000 ! multicellular anatomical structure
is_a: UBERON:0010912 ! subdivision of skeleton
intersection_of: UBERON:0010912 ! subdivision of skeleton
intersection_of: skeleton_of UBERON:0001710 ! lower jaw region
@@ -199410,7 +199404,6 @@ xref: EHDAA2:0000485
xref: EHDAA:2910
xref: EMAPA:16673
xref: VHOG:0001084
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0009891 ! facial mesenchyme
intersection_of: UBERON:0003104 ! mesenchyme
intersection_of: part_of UBERON:0000019 ! camera-type eye
@@ -199560,7 +199553,6 @@ xref: EHDAA2:0002124
xref: EHDAA:8031
xref: EMAPA:17929
xref: VHOG:0001099
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0009891 ! facial mesenchyme
is_a: UBERON:0034995 ! jaw mesenchyme
intersection_of: UBERON:0003104 ! mesenchyme
@@ -199580,7 +199572,6 @@ xref: EHDAA2:0001024
xref: EHDAA:8003
xref: EMAPA:17916
xref: VHOG:0001069
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0034995 ! jaw mesenchyme
intersection_of: UBERON:0003104 ! mesenchyme
intersection_of: part_of UBERON:0001710 ! lower jaw region
@@ -200199,7 +200190,6 @@ synonym: "pelvic fin bud ectoderm" NARROW SENSU []
xref: EHDAA2:0001034
xref: EMAPA:16780
xref: VHOG:0001048
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000490 ! unilaminar epithelium
is_a: UBERON:0005291 ! embryonic tissue
intersection_of: UBERON:0000490 ! unilaminar epithelium
@@ -200225,7 +200215,6 @@ synonym: "wing ectoderm" NARROW SENSU [Geisha:syn, NCBITaxon:8782]
xref: EHDAA2:0002134
xref: EMAPA:16407
xref: VHOG:0001047
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000490 ! unilaminar epithelium
is_a: UBERON:0005291 ! embryonic tissue
intersection_of: UBERON:0000490 ! unilaminar epithelium
@@ -200256,7 +200245,6 @@ synonym: "chorion epithelium" RELATED []
synonym: "chorionic epithelium" RELATED [BTO:0005145]
xref: BTO:0005145
xref: EMAPA:16113
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000478 ! extraembryonic structure
intersection_of: UBERON:0000478 ! extraembryonic structure
intersection_of: develops_from UBERON:0000924 ! ectoderm
@@ -200949,7 +200937,6 @@ synonym: "nerve of eyelid" EXACT [OBOL:automatic]
synonym: "palpebral nerve" EXACT [OBOL:automatic]
xref: EMAPA:37535 {source="MA:th"}
xref: MA:0001255
-is_a: CARO:0001001 ! neuron projection bundle
is_a: UBERON:0001021 ! nerve
intersection_of: UBERON:0001021 ! nerve
intersection_of: innervates UBERON:0001711 ! eyelid
@@ -200964,7 +200951,6 @@ synonym: "ciliary nerve" NARROW []
synonym: "nerve of iris" EXACT [OBOL:automatic]
xref: EMAPA:35449
xref: MA:0001291
-is_a: CARO:0001001 ! neuron projection bundle
is_a: UBERON:0001021 ! nerve
intersection_of: UBERON:0001021 ! nerve
intersection_of: innervates UBERON:0001769 ! iris
@@ -203195,7 +203181,6 @@ synonym: "textus connectivus of adult head" EXACT [OBOL:automatic]
synonym: "textus connectivus of head" EXACT [OBOL:automatic]
xref: EMAPA:16098
xref: MA:0000577
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0002384 ! connective tissue
intersection_of: UBERON:0002384 ! connective tissue
intersection_of: part_of UBERON:0000033 ! head
@@ -203292,7 +203277,6 @@ synonym: "connective tissue of trachea" EXACT [OBOL:automatic]
synonym: "connective tissue of windpipe" EXACT [OBOL:automatic]
xref: EMAPA:35876
xref: MA:0001853
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0003580 ! lower respiratory tract connective tissue
intersection_of: UBERON:0002384 ! connective tissue
intersection_of: part_of UBERON:0003126 ! trachea
@@ -203389,7 +203373,6 @@ synonym: "connective tissue of hip region" EXACT [OBOL:automatic]
synonym: "connective tissue of regio coxae" EXACT [OBOL:automatic]
xref: EMAPA:37323 {source="MA:th"}
xref: MA:0000656
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0002384 ! connective tissue
intersection_of: UBERON:0002384 ! connective tissue
intersection_of: part_of UBERON:0001464 ! hip
@@ -203445,7 +203428,6 @@ synonym: "shoulder textus connectivus" EXACT [OBOL:automatic]
synonym: "textus connectivus of shoulder" EXACT [OBOL:automatic]
xref: EMAPA:37315 {source="MA:th"}
xref: MA:0000632
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0002384 ! connective tissue
intersection_of: UBERON:0002384 ! connective tissue
intersection_of: part_of UBERON:0001467 ! shoulder
@@ -203556,7 +203538,6 @@ xref: EMAPA:35537
xref: FMA:74479
xref: FMA:74483
xref: MA:0002897
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0002384 ! connective tissue
intersection_of: UBERON:0002384 ! connective tissue
intersection_of: part_of UBERON:0001911 ! mammary gland
@@ -203619,7 +203600,6 @@ synonym: "portion of connective tissue of limb" EXACT [OBOL:automatic]
synonym: "textus connectivus of limb" EXACT [OBOL:automatic]
xref: EMAPA:37313 {source="MA:th"}
xref: MA:0000689
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0002384 ! connective tissue
intersection_of: UBERON:0002384 ! connective tissue
intersection_of: part_of UBERON:0002101 ! limb
@@ -204537,7 +204517,6 @@ xref: MESH:D003817
xref: NCIT:C13072
xref: SCTID:245543004
xref: UMLS:C0011443 {source="ncithesaurus:Dentition"}
-is_a: CARO:0000006 ! material anatomical entity
is_a: UBERON:0034925 ! anatomical collection
intersection_of: UBERON:0034925 ! anatomical collection
intersection_of: has_member UBERON:0001091 ! calcareous tooth
@@ -204597,7 +204576,6 @@ xref: MA:0001475
xref: MESH:D003393
xref: SCTID:244509003
xref: Wikipedia:Suture_(joint)
-is_a: CARO:0000006 ! material anatomical entity
is_a: UBERON:0009198 {source="GO"} ! craniofacial suture
intersection_of: UBERON:0002209 ! fibrous joint
intersection_of: part_of UBERON:0003128 ! cranium
@@ -204995,7 +204973,6 @@ xref: MESH:D009417
xref: NCIT:C13052
xref: SCTID:91728009
xref: UMLS:C0027757 {source="ncithesaurus:Nervous_Tissue"}
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000479 ! tissue
intersection_of: UBERON:0000479 ! tissue
intersection_of: has_part CL:0000125 ! glial cell
@@ -205022,7 +204999,6 @@ xref: GAID:800
xref: MESH:D013153
xref: SCTID:264198001
xref: Wikipedia:Splanchnic_nerves
-is_a: CARO:0001001 ! neuron projection bundle
is_a: UBERON:0034729 ! sympathetic nerve
intersection_of: UBERON:0001021 ! nerve
intersection_of: innervates UBERON:0000916 ! abdomen
@@ -205088,7 +205064,6 @@ xref: MA:0001102
xref: MESH:D008036
xref: SCTID:280260006
xref: Wikipedia:Lingual_nerve
-is_a: CARO:0001001 ! neuron projection bundle
is_a: UBERON:0001021 ! nerve
intersection_of: UBERON:0001021 ! nerve
intersection_of: innervates UBERON:0001723 ! tongue
@@ -205717,7 +205692,6 @@ xref: UMLS:C1709309 {source="ncithesaurus:Odontogenic_Epithelial_Remnants"}
xref: VHOG:0001443
xref: XAO:0003203
xref: ZFA:0005134
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000483 ! epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0005176 ! tooth enamel organ
@@ -205752,7 +205726,6 @@ xref: NCIT:C45713
xref: UMLS:C1711423 {source="ncithesaurus:Thymic_Epithelial_Tissue"}
xref: VHOG:0001426
xref: ZFA:0005779
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000483 ! epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0002370 ! thymus
@@ -205797,7 +205770,6 @@ xref: EHDAA:8703
xref: SCTID:278192008
xref: VHOG:0001340
xref: Wikipedia:Gonadal_vein
-is_a: CARO:0010000 ! multicellular anatomical structure
is_a: UBERON:0001638 ! vein
intersection_of: UBERON:0001638 ! vein
intersection_of: attaches_to UBERON:0000991 ! gonad
@@ -206221,7 +206193,6 @@ subset: grouping_class
subset: non_informative
synonym: "body cavity precursor" RELATED []
synonym: "future coelomic cavity lumen" EXACT []
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000464 ! anatomical space
intersection_of: UBERON:0000464 ! anatomical space
intersection_of: has_potential_to_develop_into UBERON:0002323 ! coelemic cavity lumen
@@ -206243,7 +206214,6 @@ xref: NCIT:C34195
xref: UMLS:C1512940 {source="ncithesaurus:Intraembryonic_Coelom"}
xref: VHOG:0000316
xref: Wikipedia:Intraembryonic_coelom
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0002050 ! embryonic structure
relationship: develops_from UBERON:0003081 {source="Wikipedia"} ! lateral plate mesoderm
relationship: part_of UBERON:0011997 ! coelom
@@ -206468,7 +206438,6 @@ xref: UMLS:C1518263 {source="ncithesaurus:Neural_Retina"}
xref: VHOG:0000535
xref: XAO:0003216
xref: ZFA:0000046
-is_a: CARO:0000006 ! material anatomical entity
is_a: UBERON:0001781 ! layer of retina
is_a: UBERON:0004121 ! ectoderm-derived structure
intersection_of: UBERON:0001781 ! layer of retina
@@ -206590,7 +206559,6 @@ namespace: uberon
def: "Kidney mesenchyme is the tissue made up of loosely connected mesenchymal cells in the kidney[GO]." [GO:0072074]
subset: pheno_slim
synonym: "mesenchyme of kidney" EXACT []
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0003104 ! mesenchyme
intersection_of: UBERON:0003104 ! mesenchyme
intersection_of: has_potential_to_develop_into UBERON:0002113 ! kidney
@@ -207139,7 +207107,6 @@ synonym: "thymus cortico-medullary boundary" EXACT [MP:0009543]
synonym: "thymus corticomedullary junction" EXACT [MP:0009543]
synonym: "thymus corticomedullary zone" EXACT [MP:0009543]
xref: EMAPA:37974 {source="MA:th"}
-is_a: CARO:0000006 ! material anatomical entity
is_a: PR:000050567 ! protein-containing material entity
is_a: UBERON:0007651 ! anatomical junction
intersection_of: UBERON:0007651 ! anatomical junction
@@ -207218,7 +207185,6 @@ xref: NCIT:C61572
xref: UMLS:C0180383 {source="ncithesaurus:Dermatome"}
xref: Wikipedia:Dermatome_(embryology)
xref: XAO:0000220
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0017650 {source="AEO"} ! developing mesenchymal structure
relationship: develops_from UBERON:0004290 {source="EHDAA2-abduced"} ! dermomyotome
property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/f/f3/Gray64.png" xsd:anyURI
@@ -207234,7 +207200,6 @@ synonym: "spongiotrophoblast" BROAD []
synonym: "spongiotrophoblast layer of placenta" EXACT []
xref: BTO:0005402
xref: EMAPA:31876
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000119 ! cell layer
is_a: UBERON:0005156 ! reproductive structure
is_a: UBERON:0005292 ! extraembryonic tissue
@@ -207349,7 +207314,6 @@ xref: https://upload.wikimedia.org/wikipedia/commons/thumb/a/ac/Corticogenesis_i
xref: neuronames:3233
xref: PBA:294021932
xref: Wikipedia:Subplate
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0014950 ! layer of developing cerebral cortex
intersection_of: UBERON:0014950 ! layer of developing cerebral cortex
intersection_of: adjacent_to UBERON:0004040 ! cortical intermediate zone
@@ -207371,7 +207335,6 @@ synonym: "cortical mantle layer" RELATED []
synonym: "IZ" BROAD ABBREVIATION [BRAINSPAN:BRAINSPAN]
xref: EMAPA:17545
xref: EMAPA:32712
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0014950 ! layer of developing cerebral cortex
relationship: develops_from UBERON:0004061 ! neural tube mantle layer
relationship: only_in_taxon NCBITaxon:40674 {source="Wikipedia"} ! Mammalia
@@ -207553,7 +207516,6 @@ synonym: "neural tube intermediate zone" EXACT [http://www.ncbi.nlm.nih.gov/book
xref: EMAPA:17148
xref: EMAPA:35360
xref: neuronames:1367
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0005291 ! embryonic tissue
is_a: UBERON:0034707 {source="NCBIBook:NBK10047"} ! differentiating neuroepithelium
relationship: adjacent_to UBERON:0004060 ! neural tube ventricular layer
@@ -207571,7 +207533,6 @@ synonym: "brain marginal zone" RELATED []
synonym: "neural tube marginal zone" EXACT [MP:0009691]
xref: EMAPA:17151
xref: neuronames:1368
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0005162 ! multi cell part structure
relationship: adjacent_to UBERON:0004061 ! neural tube mantle layer
relationship: develops_from UBERON:0004061 {notes="forms from axons"} ! neural tube mantle layer
@@ -207614,7 +207575,6 @@ xref: NCIT:C34111
xref: neuronames:1372
xref: UMLS:C1511061 {source="ncithesaurus:Basal_Plate"}
xref: Wikipedia:Basal_plate_(neural_tube)
-is_a: CARO:0000006 ! material anatomical entity
is_a: UBERON:0005291 ! embryonic tissue
relationship: contributes_to_morphology_of UBERON:0004061 ! neural tube mantle layer
relationship: developmentally_induced_by UBERON:0002328 {gene="Shh", source="Swenson"} ! notochord
@@ -207663,7 +207623,6 @@ xref: EMAPA:16805
xref: FMA:295864
xref: SCTID:308880000
xref: Wikipedia:Lateral_nasal_prominence
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0009292 ! embryonic nasal process
disjoint_from: UBERON:0004068 {source="lexical"} ! medial nasal prominence
relationship: develops_from UBERON:0004066 {source="Wikipedia"} ! frontonasal prominence
@@ -207688,7 +207647,6 @@ xref: FMA:295858
xref: SCTID:308877001
xref: VHOG:0000804
xref: Wikipedia:Medial_nasal_prominence
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0009292 ! embryonic nasal process
relationship: develops_from UBERON:0004066 {source="Wikipedia"} ! frontonasal prominence
relationship: in_lateral_side_of UBERON:0008816 ! embryonic head
@@ -208057,7 +208015,6 @@ name: endoderm-derived structure
namespace: uberon
def: "An anatomical structure that develops (entirely or partially) from the endoderm." [https://orcid.org/0000-0002-6601-2165]
subset: grouping_class
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000061 ! anatomical structure
intersection_of: UBERON:0000061 ! anatomical structure
intersection_of: develops_from UBERON:0000925 ! endoderm
@@ -208071,7 +208028,6 @@ namespace: uberon
def: "An anatomical structure that develops (entirely or partially) from the mesoderm." [https://orcid.org/0000-0002-6601-2165]
subset: grouping_class
synonym: "mesodermal derivative" EXACT [FBbt:00025998]
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000061 ! anatomical structure
intersection_of: UBERON:0000061 ! anatomical structure
intersection_of: develops_from UBERON:0000926 ! mesoderm
@@ -208085,7 +208041,6 @@ namespace: uberon
def: "An anatomical structure that develops (entirely or partially) from the ectoderm." [https://orcid.org/0000-0002-6601-2165]
subset: grouping_class
synonym: "ectodermal deriviative" EXACT [FBbt:00025990]
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000061 ! anatomical structure
intersection_of: UBERON:0000061 ! anatomical structure
intersection_of: develops_from UBERON:0000924 ! ectoderm
@@ -208122,7 +208077,6 @@ xref: SCTID:278861008
xref: UMLS:C0042066 {source="ncithesaurus:Genitourinary_System"}
xref: VHOG:0000286
xref: XAO:0000140
-is_a: CARO:0000006 ! material anatomical entity
is_a: UBERON:0000467 ! anatomical system
intersection_of: UBERON:0000467 ! anatomical system
intersection_of: has_part UBERON:0000990 ! reproductive system
@@ -208222,7 +208176,6 @@ xref: VHOG:0000165
xref: Wikipedia:Optic_vesicles
xref: XAO:0000228
xref: ZFA:0000050
-is_a: CARO:0000006 ! material anatomical entity
is_a: UBERON:0000479 ! tissue
is_a: UBERON:0004121 ! ectoderm-derived structure
relationship: developmentally_induced_by UBERON:0004880 ! chordamesoderm
@@ -208339,7 +208292,6 @@ synonym: "myocardial plate" EXACT [EHDAA2:0000215]
xref: EHDAA2:0000215
xref: EMAPA:16106
xref: VHOG:0000975
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0002050 ! embryonic structure
relationship: develops_from UBERON:0003084 ! heart primordium
property_value: editor_note "TODO - check plate vs rudiment vs primordium vs endocardial tube. See XAO" xsd:string
@@ -208629,7 +208581,6 @@ def: "A saclike structure of the prostate gland, comprised of at least three cel
synonym: "prostatic acinus" EXACT [FMA:66808]
synonym: "prostatic follicle" EXACT [FMA:66808]
xref: FMA:66808
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0005156 ! reproductive structure
is_a: UBERON:0009842 {source="FMA"} ! glandular acinus
relationship: develops_from UBERON:0009843 {source="PMID:18977204"} ! prostate epithelial cord
@@ -208870,7 +208821,6 @@ subset: pheno_slim
synonym: "CSB" EXACT ABBREVIATION []
xref: EMAPA:27681
xref: ZFA:0005588
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0005423 ! developing anatomical structure
relationship: develops_from UBERON:0004209 {source="ZFA"} ! renal vesicle
relationship: part_of UBERON:0010532 {source="cjm"} ! primitive nephron
@@ -208885,7 +208835,6 @@ synonym: "SSB" EXACT ABBREVIATION []
synonym: "stage II nephron" EXACT [http://www.gudmap.org/Organ_Summaries/Metanephros/Renal_vesicle.html]
xref: EMAPA:27756
xref: ZFA:0005589
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0005423 ! developing anatomical structure
relationship: develops_from UBERON:0004198 {source="GO"} ! comma-shaped body
relationship: part_of UBERON:0010532 {source="cjm"} ! primitive nephron
@@ -209034,7 +208983,6 @@ def: "Nephrogenic mesenchyme is the tissue made up of loosely connected mesenchy
comment: The detailed events associated with the differentiation of the nephrogenic mesenchyme are somewhat complex. It has been suggested that each terminal branch of the ureteric bud stimulates the associated cap mesenchyme tissue to form a renal vesicle (the most primitive stage of nephron development: a stage I nephron). This then elongates, becomes a comma-shaped and then an S-shaped body (stage II nephron), and makes contact with and fuses with the distal component of the ureteric bud. The latter then forms the collecting duct. One fold of the S-shaped body gives rise to Bowman's capsule (also termed the glomerular capsule). Soon afterwards, endothelial cells invade to make a capillary knot-like outgrowth, the glomerular tuft, which goes on to form the glomerulus. The inner epithelial layer of the Bowman's capsule (also called the visceral epithelium, or podocyte layer because it consists of podocytes) is closely apposed to the endothelial glomerulus. Together, the Bowman's capsule and the glomerulus comprise the definitive renal corpuscle. The rest of the nephron elongates to form components of the proximal tubule, the loop of Henle and the distal tubule. The distal pole of the developing nephron connects to the ureteric bud that induced it at an early stage of nephron/ collecting duct development, before differentiation of the proximal tubule, the loop of Henle and the distal tubule are complete. This connection allows the excretory products produced by the kidney to be removed and subsequently transferred, via the ureter, into the bladder where they are stored until it is appropriate to empty the bladder. [http://www.gudmap.org/About/Tutorial/DevMUS.html#DMK_Nephron]
synonym: "mesenchyme of nephron" EXACT [OBOL:automatic]
synonym: "nephron mesenchyme" EXACT [OBOL:automatic]
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0003104 ! mesenchyme
intersection_of: UBERON:0003104 ! mesenchyme
intersection_of: has_potential_to_develop_into UBERON:0001285 ! nephron
@@ -209046,7 +208994,6 @@ name: renal vesicle
namespace: uberon
def: "The renal vesicle is the primordial structure of the nephron epithelium, and is formed by the condensation of mesenchymal cells." [GO:0072077]
synonym: "stage I nephron" EXACT [http://www.gudmap.org/Organ_Summaries/Metanephros/Renal_vesicle.html, ZFA:0005586]
-is_a: CARO:0000006 ! material anatomical entity
is_a: UBERON:0007503 {source="EHDAA2"} ! epithelial vesicle
relationship: developmentally_induced_by UBERON:0000084 ! ureteric bud
relationship: develops_from UBERON:0004208 ! nephrogenic mesenchyme
@@ -210532,7 +210479,6 @@ xref: TAO:0001513
xref: UMLS:C1511786 {source="ncithesaurus:Dermomyotome"}
xref: VHOG:0000676
xref: ZFA:0001513
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000486 {source="AEO"} ! multilaminar epithelium
is_a: UBERON:0016888 {source="AEO"} ! transitional anatomical structure
relationship: develops_from UBERON:0002329 {source="EHDAA2", source="ZFA"} ! somite
@@ -210591,7 +210537,6 @@ xref: EMAPA:17271
xref: MA:0000224
xref: SCTID:276146002
xref: VHOG:0000641
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0001021 ! nerve
intersection_of: UBERON:0001021 ! nerve
intersection_of: part_of UBERON:0000011 ! parasympathetic nervous system
@@ -210751,7 +210696,6 @@ xref: SCTID:308825007
xref: UMLS:C0002084 {source="ncithesaurus:Allantois"}
xref: VHOG:0000738
xref: Wikipedia:Allantois
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0005631 ! extraembryonic membrane
relationship: develops_from UBERON:0000162 {source="Hymans"} ! cloaca
relationship: has_developmental_contribution_from UBERON:0000925 {notes="hindgut diverticulum endoderm", source="ISBN:0073040584"} ! endoderm
@@ -210783,7 +210727,6 @@ xref: SCTID:361438007
xref: UMLS:C0033153 {source="ncithesaurus:Primitive_Streak"}
xref: VHOG:0001202
xref: Wikipedia:Primitive_streak
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000485 {source="EHDAA2"} ! simple columnar epithelium
is_a: UBERON:0005291 ! embryonic tissue
relationship: develops_from UBERON:0008780 {gci_relation="part_of", gci_filler="NCBITaxon:40674", source="ISBN:9780878932504"} ! inner cell mass derived epiblast
@@ -210806,7 +210749,6 @@ xref: EHDAA2:0002091
xref: EHDAA:56
xref: EMAPA:16046
xref: VHOG:0000979
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000490 {source="EHDAA2"} ! unilaminar epithelium
is_a: UBERON:0005292 ! extraembryonic tissue
relationship: develops_from UBERON:0000085 {source="EHDAA2"} ! morula
@@ -210875,7 +210817,6 @@ xref: UMLS:C1516037 {source="ncithesaurus:Apical_Ectodermal_Ridge"}
xref: Wikipedia:Apical_ectodermal_ridge
xref: XAO:0004121
xref: ZFA:0001702
-is_a: CARO:0000006 ! material anatomical entity
is_a: UBERON:0002050 ! embryonic structure
relationship: capable_of GO:0010464 ! regulation of mesenchymal cell proliferation
relationship: capable_of GO:0061037 ! negative regulation of cartilage development
@@ -210902,7 +210843,6 @@ synonym: "limb - fin bud" EXACT [VHOG:0001258]
synonym: "paired appendage bud" EXACT []
synonym: "paired limb/fin bud" EXACT [VHOG:0001258]
xref: VHOG:0001258
-is_a: CARO:0000006 ! material anatomical entity
is_a: UBERON:0003102 ! surface structure
is_a: UBERON:0006598 ! presumptive structure
relationship: has_developmental_contribution_from UBERON:0005732 ! paired limb/fin field
@@ -211094,7 +211034,6 @@ xref: TAO:0002155
xref: UMLS:C0229127 {source="ncithesaurus:Bowman_s_Membrane"}
xref: Wikipedia:Bowman%27s_membrane
xref: ZFA:0001684
-is_a: CARO:0000003 ! connected anatomical structure
is_a: UBERON:0005769 ! basement membrane of epithelium
intersection_of: UBERON:0005769 ! basement membrane of epithelium
intersection_of: attaches_to UBERON:0001772 ! corneal epithelium
@@ -211596,7 +211535,6 @@ xref: BILA:0000061
xref: BTO:0001766
xref: NCIT:C34229
xref: UMLS:C1518306 {source="ncithesaurus:Neurula"}
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000922 ! embryo
intersection_of: UBERON:0000468 ! multicellular organism
intersection_of: existence_starts_and_ends_during UBERON:0000110 ! neurula stage
@@ -211631,7 +211569,6 @@ synonym: "musculi capitis" EXACT LATIN [FMA:71287, FMA:TA]
synonym: "set of muscles of head" EXACT [FMA:71287]
xref: EMAPA:18171
xref: FMA:71287
-is_a: CARO:0010000 ! multicellular anatomical structure
is_a: UBERON:0008229 ! craniocervical region musculature
intersection_of: UBERON:0001015 ! musculature
intersection_of: attaches_to UBERON:0003129 ! skull
@@ -211754,7 +211691,6 @@ name: set of muscles of vertebral column
namespace: uberon
synonym: "muscle group of vertebral column" EXACT [FMA:33061]
xref: FMA:33061
-is_a: CARO:0010000 ! multicellular anatomical structure
is_a: UBERON:0001015 ! musculature
intersection_of: UBERON:0001015 ! musculature
intersection_of: attaches_to UBERON:0001130 ! vertebral column
@@ -211866,7 +211802,6 @@ synonym: "hip musculature" EXACT [FMA:50227]
synonym: "muscle group of hip" EXACT [FMA:50227]
synonym: "set of muscles of hip" EXACT [FMA:50227]
xref: FMA:50227
-is_a: CARO:0010000 ! multicellular anatomical structure
is_a: UBERON:0001015 ! musculature
intersection_of: UBERON:0001015 ! musculature
intersection_of: attaches_to UBERON:0008202 ! bone of hip region
@@ -211882,7 +211817,6 @@ subset: pheno_slim
synonym: "muscle group of shoulder" EXACT [FMA:50220]
synonym: "set of muscles of shoulder" EXACT [FMA:50220]
xref: FMA:50220
-is_a: CARO:0010000 ! multicellular anatomical structure
is_a: UBERON:0001015 ! musculature
intersection_of: UBERON:0001015 ! musculature
intersection_of: attaches_to UBERON:0003461 ! shoulder bone
@@ -212310,7 +212244,6 @@ synonym: "bony projections" RELATED PLURAL [ZFA:0001637]
synonym: "projection of bone" EXACT []
xref: FMA:75433
xref: ZFA:0001637
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:4100000 ! skeletal element projection
intersection_of: UBERON:4100000 ! skeletal element projection
intersection_of: composed_primarily_of UBERON:0002481 ! bone tissue
@@ -212389,7 +212322,6 @@ xref: WikipediaCategory:Cardiovascular_system
xref: XAO:0000100
xref: XAO:0001010
xref: ZFA:0000010
-is_a: CARO:0000006 ! material anatomical entity
is_a: PR:000050567 ! protein-containing material entity
is_a: UBERON:0000467 ! anatomical system
intersection_of: UBERON:0000467 ! anatomical system
@@ -212419,7 +212351,6 @@ synonym: "trunci et ductus lymphatici" EXACT LATIN [FMA:63815, FMA:TA]
xref: FMA:63815
xref: TAO:0005105
xref: ZFA:0005105
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0002049 ! vasculature
intersection_of: UBERON:0002049 ! vasculature
intersection_of: has_part UBERON:0002391 ! lymph
@@ -212442,7 +212373,6 @@ synonym: "blood vessels" RELATED [TAO:0001079]
synonym: "set of blood vessels" EXACT []
xref: TAO:0001079
xref: ZFA:0001079
-is_a: CARO:0000000 ! anatomical entity
is_a: PR:000050567 ! protein-containing material entity
is_a: UBERON:0002049 ! vasculature
intersection_of: UBERON:0002049 ! vasculature
@@ -212656,7 +212586,6 @@ xref: EMAPA:16371
xref: MA:0002719
xref: SCTID:362030008
xref: VHOG:0000273
-is_a: CARO:0000006 ! material anatomical entity
is_a: PR:000050567 ! protein-containing material entity
is_a: UBERON:0007798 {source="MA"} ! vascular system
relationship: has_member UBERON:0001637 ! artery
@@ -212706,7 +212635,6 @@ xref: NCIT:C33858
xref: SCTID:362060003
xref: UMLS:C1267406 {source="ncithesaurus:Venous_System"}
xref: VHOG:0000277
-is_a: CARO:0000006 ! material anatomical entity
is_a: PR:000050567 ! protein-containing material entity
is_a: UBERON:0007798 {source="MA"} ! vascular system
relationship: composed_primarily_of UBERON:0001638 ! vein
@@ -212950,7 +212878,6 @@ xref: NCIT:C32732
xref: SCTID:362194004
xref: UMLS:C0227518 {source="ncithesaurus:Hepatic_Lobule"}
xref: Wikipedia:Lobules_of_liver
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000064 {source="FMA"} ! organ part
relationship: contributes_to_morphology_of UBERON:0001280 ! liver parenchyma
relationship: has_part CL:0000182 ! hepatocyte
@@ -213073,7 +213000,6 @@ xref: FMA:7135
xref: MA:0002939
xref: SCTID:278228007
xref: VHOG:0000927
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000158 ! membranous layer
is_a: UBERON:0005983 ! heart layer
intersection_of: UBERON:0000158 ! membranous layer
@@ -213600,7 +213526,6 @@ synonym: "paired appendage" NARROW [VSAO:0000067]
synonym: "pectoral or pelvic appendage" EXACT [https://orcid.org/0000-0002-6601-2165]
synonym: "pelvic/pectoral appendage" EXACT [https://orcid.org/0000-0002-6601-2165]
xref: VSAO:0000067
-is_a: CARO:0010000 ! multicellular anatomical structure
is_a: PR:000050567 ! protein-containing material entity
is_a: UBERON:0000026 {source="VSAO"} ! appendage
intersection_of: UBERON:0000026 ! appendage
@@ -213721,7 +213646,6 @@ xref: EMAPA:36040
xref: NCIT:C34131
xref: UMLS:C1516779 {source="ncithesaurus:Conceptus"}
xref: Wikipedia:Conceptus
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000061 ! anatomical structure
relationship: develops_from CL:0000365 ! animal zygote
relationship: existence_ends_with UBERON:0000068 ! embryo stage
@@ -213906,7 +213830,6 @@ xref: SCTID:280286001
xref: UMLS:C0009201 {source="ncithesaurus:Cochlear_Nerve"}
xref: VHOG:0001182
xref: Wikipedia:Cochlear_nerve
-is_a: CARO:0001001 ! neuron projection bundle
is_a: UBERON:0001021 ! nerve
intersection_of: UBERON:0001021 ! nerve
intersection_of: branching_part_of UBERON:0001648 ! vestibulocochlear nerve
@@ -213997,7 +213920,6 @@ xref: UMLS:C0017199 {source="ncithesaurus:Gastrula"}
xref: UMLS:C1284022 {source="ncithesaurus:Trilaminar_Embryonic_Disc"}
xref: Wikipedia:Gastrula
xref: Wikipedia:Trilaminar_blastocyst
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000922 ! embryo
intersection_of: UBERON:0000468 ! multicellular organism
intersection_of: existence_starts_and_ends_during UBERON:0000109 ! gastrula stage
@@ -214139,7 +214061,6 @@ xref: SCTID:309311006
xref: VSAO:0000015
xref: XAO:0004038
xref: ZFA:0005619
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0002384 {source="VSAO"} ! connective tissue
relationship: develops_from CL:0007001 {date_retrieved="2012-08-14", external_class="VSAO:0000015", source="VSAO"} ! skeletogenic cell
relationship: part_of UBERON:0004765 ! skeletal element
@@ -214205,7 +214126,6 @@ xref: SCTID:155540009
xref: UMLS:C1516496 {source="ncithesaurus:Chondrocranium"}
xref: Wikipedia:Chondrocranium
xref: XAO:0003059
-is_a: CARO:0000006 ! material anatomical entity
is_a: UBERON:0000075 {source="FMA"} ! subdivision of skeletal system
relationship: develops_from UBERON:0009617 {source="PMC1571569"} ! head paraxial mesoderm
relationship: has_part UBERON:0002418 ! cartilage tissue
@@ -215298,7 +215218,6 @@ xref: BTO:0000417
xref: MA:0001629
xref: NCIT:C43616
xref: UMLS:C1711208 {source="ncithesaurus:Bile_Duct_Epithelium"}
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0034932 ! epithelium of biliary system
is_a: UBERON:0034969 ! epithelial layer of duct
intersection_of: UBERON:0000483 ! epithelium
@@ -215887,7 +215806,6 @@ xref: NCIT:C34219
xref: SCTID:361405003
xref: UMLS:C1283944 {source="ncithesaurus:Nephrogenic_Cord"}
xref: Wikipedia:Nephrogenic_cord
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0002050 ! embryonic structure
relationship: develops_from UBERON:0004876 ! urogenital fold
@@ -216135,7 +216053,6 @@ xref: NCIT:C33010
xref: SCTID:279973004
xref: UMLS:C0226875 {source="ncithesaurus:Lower_Gastrointestinal_Tract"}
xref: Wikipedia:Alimentary_canal#Upper_gastrointestinal_tract
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0004921 ! subdivision of digestive tract
relationship: develops_from UBERON:0001046 ! hindgut
relationship: part_of UBERON:0005409 ! alimentary part of gastrointestinal system
@@ -216156,7 +216073,6 @@ xref: NCIT:C33837
xref: SCTID:181244000
xref: UMLS:C0226874 {source="ncithesaurus:Upper_Gastrointestinal_Tract"}
xref: Wikipedia:Alimentary_canal#Upper_gastrointestinal_tract
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0004921 ! subdivision of digestive tract
relationship: develops_from UBERON:0001041 ! foregut
property_value: UBPROP:0000012 "WP: small intestine, large intestine, anus. Anal canal not part of LGIT according to FMA, but anus is considered part of LGIT according to WP. Duodenum overlaps both U/L. In Galen, entire GI tract excludes esophagus" xsd:string {external_ontology="FMA"}
@@ -218277,7 +218193,6 @@ synonym: "forebrain-midbrain boundary region" EXACT [EMAPA:36449]
xref: EMAPA:36449
xref: TAO:0001367
xref: ZFA:0001367
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0007651 ! anatomical junction
intersection_of: UBERON:0007651 ! anatomical junction
intersection_of: adjacent_to UBERON:0001890 ! forebrain
@@ -218430,7 +218345,6 @@ synonym: "muscle element" RELATED []
synonym: "musculus" EXACT [FMA:30316]
xref: EMAPA:32715
xref: FMA:30316
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000061 ! anatomical structure
relationship: has_part CL:0000187 ! muscle cell
relationship: only_in_taxon NCBITaxon:6072 ! Eumetazoa
@@ -218456,7 +218370,6 @@ name: kidney rudiment
namespace: uberon
def: "." [GO:0072003]
synonym: "kidney anlage" RELATED [GOC:mtg_kidney_jan10]
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0002050 ! embryonic structure
relationship: develops_from UBERON:0007687 {source="GO"} ! kidney field
property_value: editor_note "class added for consistency with GO - consider merging with kidney mesenchyme." xsd:string
@@ -219146,7 +219059,6 @@ xref: SCTID:258971005
xref: TAO:0001112
xref: Wikipedia:Membrana_granulosa
xref: ZFA:0001112
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000119 ! cell layer
is_a: UBERON:0004911 ! epithelium of female gonad
intersection_of: UBERON:0000119 ! cell layer
@@ -219552,7 +219464,6 @@ def: "Stromal matrix surrounding blood vessels within the choroid plexus." [PMCI
synonym: "choroid plexus stromal matrix" EXACT [PMCID:PMC3496674]
xref: EMAPA:36609
xref: MA:0000825
-is_a: CARO:0000000 ! anatomical entity
is_a: PR:000050567 ! protein-containing material entity
is_a: UBERON:0003891 ! stroma
intersection_of: UBERON:0003891 ! stroma
@@ -219627,7 +219538,6 @@ synonym: "testis interstitium" EXACT [https://orcid.org/0000-0002-6601-2165]
xref: EMAPA:18687
xref: MA:0002713
xref: SCTID:362280005
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0005156 ! reproductive structure
is_a: UBERON:0005169 ! interstitial tissue
intersection_of: UBERON:0005169 ! interstitial tissue
@@ -219687,7 +219597,6 @@ xref: FMA:70983
xref: MA:0002616
xref: NCIT:C33459
xref: SCTID:362210003
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0005169 ! interstitial tissue
intersection_of: UBERON:0005169 ! interstitial tissue
intersection_of: part_of UBERON:0002113 ! kidney
@@ -219794,7 +219703,6 @@ def: "An epithelium that is part of a hindlimb stylopod [Automatically generated
xref: EHDAA2:0002131
xref: EMAPA:17500
xref: VHOG:0001041
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000483 ! epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0000376 ! hindlimb stylopod
@@ -219811,7 +219719,6 @@ synonym: "hind limb digit epithelium" EXACT [OBOL:accepted]
synonym: "toe epithelium" EXACT []
xref: EMAPA:32946
xref: VHOG:0001031
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000490 {source="EHDAA2"} ! unilaminar epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0001466 ! pedal digit
@@ -219829,7 +219736,6 @@ synonym: "hand digit epithelium" NARROW SENSU [NCBITaxon:9606, OBOL:accepted]
xref: EHDAA2:0000406
xref: EMAPA:32647
xref: VHOG:0001032
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000490 ! unilaminar epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0002389 ! manual digit
@@ -219844,7 +219750,6 @@ def: "An epithelium that is part of a forelimb stylopod [Automatically generated
xref: EHDAA2:0002113
xref: EMAPA:17425
xref: VHOG:0000990
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000483 ! epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0003822 ! forelimb stylopod
@@ -219859,7 +219764,6 @@ def: "An epithelium that is part of a lower leg [Automatically generated definit
xref: EHDAA2:0001031
xref: EMAPA:17497
xref: VHOG:0001050
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000483 ! epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0003823 ! hindlimb zeugopod
@@ -220036,7 +219940,6 @@ synonym: "pedal digital ray mesenchyme" RELATED [https://orcid.org/0000-0002-660
synonym: "toe mesenchyme" EXACT []
xref: EMAPA:32947
xref: VHOG:0000463
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0003860 ! hindlimb mesenchyme
is_a: UBERON:0010702 ! digit mesenchyme
intersection_of: UBERON:0003104 ! mesenchyme
@@ -220081,7 +219984,6 @@ synonym: "manual digital ray mesenchyme" RELATED [https://orcid.org/0000-0002-66
xref: EHDAA2:0000407
xref: EMAPA:32645
xref: VHOG:0001416
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0003859 ! forelimb mesenchyme
is_a: UBERON:0010702 ! digit mesenchyme
intersection_of: UBERON:0003104 ! mesenchyme
@@ -220404,7 +220306,6 @@ xref: UMLS:C0231047 {source="ncithesaurus:Urogenital_Ridge"}
xref: UMLS:C1512243 {source="ncithesaurus:Gonadal_Ridge"}
xref: Wikipedia:Gonadal_ridge
xref: XAO:0000018
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0002050 ! embryonic structure
relationship: develops_from UBERON:0004876 ! urogenital fold
relationship: part_of UBERON:0004122 ! genitourinary system
@@ -220555,7 +220456,6 @@ namespace: uberon
def: "The mammary placode is a transient lens shaped structure that will give rise to the mammary bud proper[GO]." [GO:0060596]
synonym: "mammary anlage" RELATED []
xref: EMAPA:35541
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0011814 {source="NCBIBook:NBK53175"} ! non-neurogenic ectodermal placode
relationship: develops_from UBERON:0008425 {source="Stedmans"} ! mammary ridge
relationship: part_of UBERON:0000076 {source="PMID:20484386"} ! external ectoderm
@@ -220849,7 +220749,6 @@ xref: EMAPA:32711
xref: MBA:695
xref: neuronames:2702
xref: PBA:294021914
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0014950 ! layer of developing cerebral cortex
relationship: has_potential_to_develop_into UBERON:0001950 {source="NCBIBook:NBK10047"} ! neocortex
property_value: UBPROP:0000011 "A single stem cell in the ventricular layer can give rise to neurons (and glial cells) in any of the cortical layers (Walsh and Cepko 1988)[NCBIBook:NBK10047]" xsd:string
@@ -221030,7 +220929,6 @@ subset: pheno_slim
synonym: "hippocampus granular layer" RELATED []
xref: EMAPA:35406
xref: MA:0000954
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0002305 ! layer of hippocampus
intersection_of: UBERON:0002305 ! layer of hippocampus
intersection_of: composed_primarily_of CL:0001033 ! hippocampal granule cell
@@ -221169,7 +221067,6 @@ xref: FMA:83146
xref: MA:0000946
xref: MBA:632
xref: neuronames:2122
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0002304 ! layer of dentate gyrus
intersection_of: UBERON:0002304 ! layer of dentate gyrus
intersection_of: immediately_deep_to UBERON:0004679 ! dentate gyrus molecular layer
@@ -221311,7 +221208,6 @@ xref: MESH:D009831
xref: NCIT:C33205
xref: UMLS:C0028937 {source="ncithesaurus:Olfactory_Mucosa"}
xref: Wikipedia:Olfactory_mucosa
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0001826 ! nasal cavity mucosa
intersection_of: UBERON:0001826 ! nasal cavity mucosa
intersection_of: has_part UBERON:0001997 ! olfactory epithelium
@@ -221377,7 +221273,6 @@ xref: neuronames:2444
xref: NLXANAT:090807
xref: PBA:294021786
xref: UMLS:C1709063 {source="ncithesaurus:Molecular_Layer"}
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0002301 ! layer of neocortex
relationship: develops_from UBERON:0014935 {source="NBK10047"} ! cerebral cortex marginal layer
@@ -221409,7 +221304,6 @@ xref: neuronames:2446
xref: NLXANAT:090808
xref: PBA:294021800
xref: UMLS:C1517039 {source="ncithesaurus:External_Granular_Layer"}
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0002301 ! layer of neocortex
relationship: develops_from UBERON:0005343 {source="BRAINSPAN"} ! cortical plate
relationship: immediately_deep_to UBERON:0005390 ! cortical layer I
@@ -221444,7 +221338,6 @@ xref: neuronames:2448
xref: NLXANAT:090809
xref: PBA:294021824
xref: UMLS:C1517046 {source="ncithesaurus:External_Pyramidal_Cell_Layer"}
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0002301 ! layer of neocortex
relationship: develops_from UBERON:0005343 {source="BRAINSPAN"} ! cortical plate
relationship: has_part CL:0000598 ! pyramidal neuron
@@ -221477,7 +221370,6 @@ xref: neuronames:2449
xref: NLXANAT:090810
xref: PBA:294021852
xref: UMLS:C1512872 {source="ncithesaurus:Internal_Granular_Layer"}
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0002301 ! layer of neocortex
relationship: develops_from UBERON:0005343 {source="BRAINSPAN"} ! cortical plate
relationship: immediately_deep_to UBERON:0005392 ! cortical layer III
@@ -221519,7 +221411,6 @@ xref: neuronames:2450
xref: NLXANAT:090811
xref: PBA:294021878
xref: UMLS:C1517447 {source="ncithesaurus:Ganglionic_Layer"}
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0002301 ! layer of neocortex
relationship: develops_from UBERON:0005343 {source="BRAINSPAN"} ! cortical plate
relationship: has_part CL:0000598 ! pyramidal neuron
@@ -222093,7 +221984,6 @@ xref: SCTID:361510002
xref: TAO:0002205
xref: VHOG:0001163
xref: ZFA:0001679
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000479 ! tissue
relationship: develops_from UBERON:0003073 ! lens placode
relationship: has_quality PATO:0001736 {gci_relation="part_of", gci_filler="NCBITaxon:32443", notes="teleosts"} ! solid configuration
@@ -222680,6 +222570,28 @@ is_a: UBERON:0004120 ! mesoderm-derived structure
relationship: develops_from UBERON:0004291 {source="ZFA"} ! heart rudiment
relationship: part_of UBERON:0000922 ! embryo
+[Term]
+id: UBERON:0005499
+name: rhombomere 1
+namespace: uberon
+def: "Hindbrain segment or neuromere 1." [ZFA:0001031]
+subset: efo_slim
+subset: pheno_slim
+subset: vertebrate_core
+synonym: "r1" EXACT ABBREVIATION [ZFA:0001031]
+xref: DHBA:12667
+xref: DMBA:16915
+xref: EFO:0003608
+xref: EHDAA2:0001637
+xref: EMAPA:16290
+xref: FMA:295790
+xref: TAO:0001031
+xref: ZFA:0001031
+is_a: UBERON:0001892 ! rhombomere
+relationship: develops_from UBERON:0007289 {evidence="definitional"} ! presumptive rhombomere 1
+property_value: UBPROP:0000001 "Hindbrain segment or neuromere. Kimmel et al, 1995.[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0001031", ontology="TAO", source="ZFIN:curator"}
+property_value: UBPROP:0000111 "1" xsd:nonNegativeInteger
+
[Term]
id: UBERON:0005501
name: rhombomere lateral wall
@@ -222763,7 +222675,6 @@ xref: RETIRED_EHDAA2:0002148
xref: TAO:0001262
xref: WBbt:0008366
xref: ZFA:0001262
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0001048 {source="Obol"} ! primordium
relationship: has_potential_to_develop_into UBERON:0000991 ! gonad
relationship: located_in UBERON:0002323 {gci_relation="part_of", gci_filler="NCBITaxon:33511", notes="conservatively place at deuterostome, excluding acoelomates"} ! coelemic cavity lumen
@@ -222791,6 +222702,22 @@ is_a: UBERON:0014387 ! mesenchyme derived from neural crest
relationship: develops_from UBERON:0003849 {source="EHDAA2"} ! mesencephalic neural crest
property_value: UBPROP:0000003 "We conclude this section by listing some of the many synapomorphies of craniates, including (1) the neural crest (...).[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000268", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.43", source="http://bgee.unil.ch/"}
+[Term]
+id: UBERON:0005567
+name: rhombomere 1 lateral wall
+namespace: uberon
+def: "A rhombomere lateral wall that is part of a rhombomere 1." [OBOL:automatic]
+subset: vertebrate_core
+synonym: "lateral wall rhombomere 1" EXACT [ZFA:0000781]
+xref: EHDAA2:0001641
+xref: EMAPA:16482
+xref: TAO:0000781
+xref: ZFA:0000781
+is_a: UBERON:0005501 ! rhombomere lateral wall
+intersection_of: UBERON:0005501 ! rhombomere lateral wall
+intersection_of: part_of UBERON:0005499 ! rhombomere 1
+relationship: part_of UBERON:0005499 ! rhombomere 1
+
[Term]
id: UBERON:0005594
name: head somite
@@ -222825,7 +222752,6 @@ xref: AAO:0011059
xref: EFO:0002578
xref: EMAPA:36007
xref: XAO:0001002
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0001048 {source="XAO"} ! primordium
relationship: develops_from UBERON:0001041 {source="XAO"} ! foregut
relationship: has_potential_to_develop_into UBERON:0000170 ! pair of lungs
@@ -223069,7 +222995,6 @@ synonym: "tubotympanic recess" RELATED [EHDAA2:0002095]
synonym: "tubotympanic recess cavity" EXACT []
synonym: "tubotympanic recess space" EXACT []
xref: EHDAA2:0002095
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0002553 ! anatomical cavity
is_a: UBERON:0007473 ! lumen of epithelial sac
intersection_of: UBERON:0002553 ! anatomical cavity
@@ -223112,7 +223037,6 @@ xref: EHDAA2:0004112
xref: EMAPA:35904
xref: FMA:5900
xref: XAO:0004143
-is_a: CARO:0000000 ! anatomical entity
is_a: PR:000050567 ! protein-containing material entity
is_a: UBERON:0002049 ! vasculature
relationship: has_part UBERON:0001981 ! blood vessel
@@ -223670,7 +223594,6 @@ def: "A ring of cells capable of forming a limb or paired fin[Gilbert,modified].
subset: homology_grouping
synonym: "limb/fin field of lateral plate mesoderm" EXACT []
synonym: "paired limb/fin field" EXACT []
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0002050 ! embryonic structure
is_a: UBERON:0005291 ! embryonic tissue
is_a: UBERON:0007688 ! anlage
@@ -224364,7 +224287,6 @@ xref: FMA:293051
xref: NCIT:C34204
xref: UMLS:C1512982 {source="ncithesaurus:Mandibular_Prominence"}
xref: Wikipedia:Mandibular_prominence
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0012314 ! embryonic facial prominence
relationship: develops_from UBERON:0007237 ! 1st arch mandibular component
relationship: part_of UBERON:0000166 ! oral opening
@@ -224388,7 +224310,6 @@ xref: NCIT:C34206
xref: SCTID:346355001
xref: UMLS:C1513037 {source="ncithesaurus:Maxillary_Prominence"}
xref: Wikipedia:Maxillary_prominence
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0002050 ! embryonic structure
relationship: develops_from UBERON:0007238 ! 1st arch maxillary component
property_value: depicted_by "http://upload.wikimedia.org/wikipedia/commons/2/2d/Gray48.png" xsd:anyURI
@@ -224411,7 +224332,6 @@ xref: SCTID:361485001
xref: Wikipedia:Nasal_pit
xref: XAO:0000275
xref: XAO:0004073
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0016566 {source="EHDAA2"} ! pit
relationship: develops_from UBERON:0003050 {source="XAO:0000275 nasal pit"} ! olfactory placode
relationship: located_in UBERON:0005384 {source="EHDAA2"} ! nasal cavity epithelium
@@ -224540,7 +224460,6 @@ xref: FMA:302888
xref: SCTID:308798005
xref: VHOG:0000583
xref: Wikipedia:Genital_tubercle
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0002050 ! embryonic structure
relationship: develops_from UBERON:0004874 ! somatopleure
relationship: has_potential_to_develop_into UBERON:0011757 ! differentiated genital tubercle
@@ -224631,7 +224550,6 @@ xref: AAO:0010370
xref: TAO:0001276
xref: XAO:0003177
xref: ZFA:0001276
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0010912 ! subdivision of skeleton
relationship: develops_from UBERON:0003066 {source="cjm"} ! pharyngeal arch 2
relationship: part_of UBERON:0008895 {source="ZFA"} ! splanchnocranium
@@ -224646,7 +224564,6 @@ synonym: "celomic epithelium" EXACT []
synonym: "germinal epithelium of Waldeyer" EXACT [Wikipedia:Coelomic_epithelium]
xref: Wikipedia:Coelomic_epithelium
xref: XAO:0000329
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000483 ! epithelium
relationship: has_developmental_contribution_from UBERON:0004871 {source="XAO"} ! somatic layer of lateral plate mesoderm
relationship: has_developmental_contribution_from UBERON:0004872 {source="XAO"} ! splanchnic layer of lateral plate mesoderm
@@ -224829,7 +224746,6 @@ name: zone of bone organ
namespace: uberon
synonym: "bone organ zone" EXACT [FMA:10483]
xref: FMA:10483
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0034944 {source="FMA"} ! zone of organ
relationship: composed_primarily_of UBERON:0002481 ! bone tissue
relationship: part_of UBERON:0001474 ! bone element
@@ -224922,7 +224838,6 @@ xref: BTO:0003971
xref: EMAPA:32792
xref: FMA:70935
xref: MA:0000779
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0005933 ! hair root sheath
relationship: has_part CL:0000312 ! keratinocyte
@@ -224967,7 +224882,6 @@ xref: UMLS:C0222645 {source="ncithesaurus:Axial_Skeleton"}
xref: VSAO:0000056
xref: Wikipedia:Axial_skeleton
xref: XAO:0004011
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0010912 ! subdivision of skeleton
relationship: connected_to UBERON:0002091 {gci_relation="part_of", gci_filler="NCBITaxon:7776"} ! appendicular skeleton
relationship: contributes_to_morphology_of UBERON:0001434 ! skeletal system
@@ -225028,7 +224942,6 @@ xref: FMA:7216
xref: NCIT:C61368
xref: SCTID:244379003
xref: UMLS:C1881209 {source="ncithesaurus:Infundibulum"}
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0005337 ! outflow tract of ventricle
intersection_of: UBERON:0005337 ! outflow tract of ventricle
intersection_of: part_of UBERON:0002080 ! heart right ventricle
@@ -225124,7 +225037,6 @@ xref: NCIT:C12803
xref: SCTID:280694002
xref: UMLS:C0040573 {source="ncithesaurus:Trabecular_Meshwork"}
xref: Wikipedia:Trabecular_meshwork
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000479 ! tissue
relationship: has_part CL:0002367 ! trabecular meshwork cell
relationship: overlaps UBERON:0006206 ! iridocorneal angle
@@ -225141,7 +225053,6 @@ def: "A sheet of somatopleure that grows upward over the embryo and eventually m
subset: pheno_slim
synonym: "amnionic fold" EXACT [http://placentation.ucsd.edu/glossfs.html]
xref: EMAPA:16076
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000478 ! extraembryonic structure
relationship: develops_from UBERON:0004874 {source="ISBN:0073040584"} ! somatopleure
relationship: only_in_taxon NCBITaxon:32524 ! Amniota
@@ -225328,7 +225239,6 @@ synonym: "lower part of bulb of hair follicle" EXACT [FMA:70772]
synonym: "lower zone of bulb of hair follicle" EXACT [FMA:70772]
xref: EMAPA:37878 {source="MA:th"}
xref: FMA:70772
-is_a: CARO:0000006 ! material anatomical entity
is_a: UBERON:0019204 ! skin epithelium
relationship: adjacent_to UBERON:0000412 ! dermal papilla
relationship: contributes_to_morphology_of UBERON:0005932 ! bulb of hair follicle
@@ -225376,7 +225286,6 @@ name: multi-limb segment region
namespace: uberon
def: "A collection of two or more connected limb segments. Examples: arm (comprising stylopod and zeugopod regions)." [https://orcid.org/0000-0002-6601-2165]
subset: non_informative
-is_a: CARO:0000006 ! material anatomical entity
is_a: UBERON:0010758 ! subdivision of organism along appendicular axis
relationship: has_part UBERON:0002529 ! limb segment
property_value: seeAlso "https://github.com/obophenotype/uberon/issues/514" xsd:anyURI
@@ -225448,7 +225357,6 @@ synonym: "post-anal tail region" RELATED [http://orcid.org/0000-0002-6601-2165]
synonym: "postsacral region" RELATED [AAO:0000082]
synonym: "tail region" RELATED [AAO:0000082]
xref: XAO:0000087
-is_a: CARO:0010000 ! multicellular anatomical structure
is_a: UBERON:0011676 ! subdivision of organism along main body axis
relationship: has_skeleton UBERON:0006076 ! caudal region of vertebral column
relationship: part_of UBERON:0000154 ! posterior region of body
@@ -225583,7 +225491,6 @@ xref: SCTID:362226002
xref: UMLS:C0447584 {source="ncithesaurus:Bladder_Fundus"}
xref: VHOG:0001184
xref: Wikipedia:Fundus_of_the_urinary_bladder#Fundus
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000064 ! organ part
relationship: contributes_to_morphology_of UBERON:0001255 ! urinary bladder
relationship: develops_from UBERON:0005760 {source="EHDAA2-modified"} ! urorectal septum
@@ -225835,7 +225742,6 @@ xref: EHDAA:2592
xref: EMAPA:16827
xref: VHOG:0000502
xref: Wikipedia:Aorticopulmonary_septum
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0004142 ! outflow tract septum
intersection_of: UBERON:0002099 ! cardiac septum
intersection_of: adjacent_to UBERON:0002333 ! pulmonary trunk
@@ -225893,7 +225799,6 @@ xref: FMA:313607
xref: SCTID:361412007
xref: VHOG:0000380
xref: Wikipedia:Buccopharyngeal_membrane
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0003037 ! septum
relationship: has_developmental_contribution_from UBERON:0000924 ! ectoderm
relationship: has_developmental_contribution_from UBERON:0000925 ! endoderm
@@ -225993,7 +225898,6 @@ xref: SCTID:308826008
xref: UMLS:C0231056 {source="ncithesaurus:Cloacal_Membrane"}
xref: VHOG:0001198
xref: Wikipedia:Cloacal_membrane
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000158 ! membranous layer
relationship: contributes_to_morphology_of UBERON:0000163 ! embryonic cloaca
relationship: develops_from UBERON:0004341 {source="Wikipedia"} ! primitive streak
@@ -226057,7 +225961,6 @@ subset: emapa_ehdaa2
xref: EHDAA2:0000431
xref: EHDAA:8483
xref: EMAPA:17710
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0001048 ! primordium
relationship: has_potential_to_develop_into UBERON:0001490 ! elbow joint
relationship: part_of UBERON:0003318 ! mesenchyme of elbow
@@ -226071,7 +225974,6 @@ xref: EHDAA2:0000456
xref: EHDAA:8363
xref: EMAPA:18023
xref: FMA:312597
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0001048 ! primordium
intersection_of: UBERON:0001048 ! primordium
intersection_of: has_potential_to_develop_into UBERON:0001679 ! ethmoid bone
@@ -226091,7 +225993,6 @@ xref: EHDAA:1477
xref: EMAPA:16660
xref: RETIRED_EHDAA2:0000496
xref: VHOG:0000715
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0002050 ! embryonic structure
relationship: develops_from UBERON:0005565 ! facio-acoustic neural crest
relationship: part_of UBERON:0001714 {source="EHDAA2"} ! cranial ganglion
@@ -226159,7 +226060,6 @@ xref: EHDAA2:0000577
xref: EHDAA:9540
xref: EMAPA:18017
xref: FMA:312589
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0001048 ! primordium
intersection_of: UBERON:0001048 ! primordium
intersection_of: has_potential_to_develop_into UBERON:0000209 ! tetrapod frontal bone
@@ -226398,7 +226298,6 @@ synonym: "lingual swelling" RELATED [EHDAA2:0000996]
xref: EHDAA2:0000996
xref: EMAPA:17186
xref: VHOG:0000449
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0002050 ! embryonic structure
is_a: UBERON:0010188 {source="EHDAA2"} ! protuberance
relationship: develops_from UBERON:0004362 ! pharyngeal arch 1
@@ -226458,7 +226357,6 @@ xref: NCIT:C34218
xref: UMLS:C1513875 {source="ncithesaurus:Nasolacrimal_Groove"}
xref: VHOG:0001307
xref: Wikipedia:Lacrimal_groove
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000490 {source="EHDAA2"} ! unilaminar epithelium
is_a: UBERON:0005291 ! embryonic tissue
is_a: UBERON:0019306 ! nose epithelium
@@ -226504,7 +226402,6 @@ xref: FMA:293135
xref: NCIT:C34232
xref: UMLS:C1518430 {source="ncithesaurus:Notochordal_Process"}
xref: VHOG:0001213
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0005423 ! developing anatomical structure
relationship: develops_from UBERON:0000924 {source="EHDAA2"} ! ectoderm
relationship: only_in_taxon NCBITaxon:7711 ! Chordata
@@ -226540,7 +226437,6 @@ xref: FMA:302911
xref: NCIT:C34238
xref: VHOG:0001147
xref: Wikipedia:Otic_pit
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0016566 {source="EHDAA2"} ! pit
relationship: has_potential_to_develop_into UBERON:0003051 ! ear vesicle
relationship: part_of UBERON:0003069 ! otic placode
@@ -226723,7 +226619,6 @@ xref: EHDAA2:0001904
xref: EHDAA:3003
xref: EMAPA:18535
xref: XAO:0000326
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0001048 {source="XAO"} ! primordium
is_a: UBERON:0002050 ! embryonic structure
is_a: UBERON:0003104 ! mesenchyme
@@ -227507,7 +227402,6 @@ synonym: "presumptive structures" EXACT [ZFA:0001116]
xref: AAO:0000479
xref: TAO:0001116
xref: ZFA:0001116
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0002050 ! embryonic structure
intersection_of: UBERON:0005423 ! developing anatomical structure
intersection_of: has_potential_to_develop_into UBERON:0000061 ! anatomical structure
@@ -227614,7 +227508,6 @@ xref: SCTID:331712004
xref: UMLS:C0225205 {source="ncithesaurus:Aponeurosis"}
xref: Wikipedia:Aponeurosis
xref: ZFA:0005652
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000158 {source="FMA"} ! membranous layer
relationship: has_part CL:0000327 {source="AEO"} ! extracellular matrix secreting cell
relationship: part_of UBERON:0001630 {source="FMA"} ! muscle organ
@@ -227948,7 +227841,6 @@ xref: SCTID:244943002
xref: UMLS:C0230162 {source="ncithesaurus:Central_Tendon_of_the_Diaphragm"}
xref: VHOG:0001399
xref: Wikipedia:Central_tendon_of_diaphragm
-is_a: CARO:0010000 ! multicellular anatomical structure
is_a: UBERON:0000043 ! tendon
is_a: UBERON:0003570 ! respiratory system connective tissue
is_a: UBERON:0003837 ! thoracic segment connective tissue
@@ -228073,7 +227965,6 @@ synonym: "mesopod" RELATED []
synonym: "mesopodial limb segment" EXACT [MA:th]
synonym: "mesopodial segment" EXACT []
xref: Wikipedia:Carpus_and_tarsus_of_land_vertebrates
-is_a: CARO:0010000 ! multicellular anatomical structure
is_a: UBERON:0002529 ! limb segment
intersection_of: UBERON:0002529 ! limb segment
intersection_of: distally_connected_to UBERON:0009877 ! metapodium region
@@ -228095,7 +227986,6 @@ synonym: "autopodium" RELATED [VSAO:0005019, VSAO:NI]
synonym: "skeletal parts of autopod" EXACT [https://orcid.org/0000-0002-6601-2165]
synonym: "skeleton of autopod" EXACT [https://orcid.org/0000-0002-6601-2165]
xref: VSAO:0005019
-is_a: CARO:0010000 ! multicellular anatomical structure
is_a: UBERON:0010712 ! limb skeleton subdivision
intersection_of: UBERON:0010912 ! subdivision of skeleton
intersection_of: skeleton_of UBERON:0002470 ! autopod region
@@ -228172,7 +228062,6 @@ xref: FMA:312476
xref: SCTID:308821003
xref: VHOG:0000730
xref: Wikipedia:Tuberculum_impar
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0002050 ! embryonic structure
relationship: develops_from UBERON:0004362 ! pharyngeal arch 1
relationship: part_of UBERON:0006260 {source="EHDAA2"} ! lingual swellings
@@ -228193,7 +228082,6 @@ xref: EMAPA:17189
xref: FMA:313628
xref: VHOG:0000731
xref: Wikipedia:Lateral_lingual_swelling
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0002050 ! embryonic structure
relationship: develops_from UBERON:0004362 ! pharyngeal arch 1
relationship: part_of UBERON:0006260 ! lingual swellings
@@ -228283,7 +228171,6 @@ synonym: "skeleton of nose" EXACT [FMA:60116]
xref: AAO:0000320
xref: FMA:60116
xref: SCTID:281486007
-is_a: CARO:0010000 ! multicellular anatomical structure
is_a: UBERON:0000075 {source="FMA"} ! subdivision of skeletal system
is_a: UBERON:0010912 ! subdivision of skeleton
intersection_of: UBERON:0010912 ! subdivision of skeleton
@@ -228304,7 +228191,6 @@ synonym: "loose connective tissue" RELATED [AAO:0000027]
xref: AAO:0000027
xref: FMA:63897
xref: SCTID:68477002
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0011825 {source="FMA"} ! loose connective tissue
relationship: has_part CL:1000303 {source="FMA"} ! fibroblast of areolar connective tissue
relationship: part_of UBERON:0000030 ! lamina propria
@@ -228641,7 +228527,6 @@ synonym: "rectum" NARROW [FBbt:00005756]
synonym: "terminal section of digestive tract" RELATED []
xref: FBbt:00005756
xref: WBbt:0005773
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0004921 ! subdivision of digestive tract
relationship: continuous_with UBERON:0001245 ! anus
relationship: develops_from UBERON:0001046 ! hindgut
@@ -229116,7 +229001,6 @@ synonym: "ampullary crest neuroepithelium" RELATED [MA:0002870]
synonym: "epithelium of crista of ampulla of semicircular duct of membranous labyrinth" EXACT [FMA:75636]
xref: FMA:75636
xref: MA:0002870
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0006932 {source="FMA"} ! vestibular epithelium
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0004721 ! crista ampullaris
@@ -229298,7 +229182,6 @@ xref: NCIT:C33638
xref: SCTID:259306002
xref: UMLS:C0737271 {source="ncithesaurus:Stroma_of_the_Ovarian_Cortex"}
xref: Wikipedia:Stroma_of_ovary
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0003891 ! stroma
is_a: UBERON:0005156 ! reproductive structure
intersection_of: UBERON:0003891 ! stroma
@@ -229358,7 +229241,6 @@ subset: efo_slim
xref: EFO:0003709
xref: TAO:0005077
xref: ZFA:0005077
-is_a: CARO:0000006 ! material anatomical entity
is_a: PR:000050567 ! protein-containing material entity
is_a: UBERON:0005423 ! developing anatomical structure
relationship: has_part CL:0000115 ! endothelial cell
@@ -229414,7 +229296,6 @@ xref: FMA:293143
xref: SCTID:360387000
xref: VHOG:0001641
xref: XAO:0000235
-is_a: CARO:0000006 ! material anatomical entity
is_a: UBERON:0005291 ! embryonic tissue
relationship: developmentally_induced_by UBERON:0009881 ! anterior lateral plate mesoderm
relationship: develops_from UBERON:0004872 ! splanchnic layer of lateral plate mesoderm
@@ -229581,7 +229462,6 @@ xref: NCIT:C34125
xref: SCTID:360403003
xref: UMLS:C0008508 {source="ncithesaurus:Chorionic_Villus"}
xref: Wikipedia:Chorionic_villi
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000478 ! extraembryonic structure
is_a: UBERON:0002050 ! embryonic structure
relationship: develops_from UBERON:0004027 {source="MP-def"} ! chorionic plate
@@ -229807,7 +229687,6 @@ def: "Portion of tissue that consists of the precursors of the pronephric glomus
synonym: "corpuscle" RELATED [XAO:0000110]
synonym: "glomerulus" RELATED [XAO:0000110]
xref: XAO:0000110
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0002050 ! embryonic structure
relationship: develops_from UBERON:0003064 ! intermediate mesoderm
@@ -229883,7 +229762,6 @@ synonym: "embryonic tail" RELATED [FMA:85540]
synonym: "tail of embryo" EXACT [FMA:85540]
xref: EMAPA:16748
xref: FMA:85540
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0002050 ! embryonic structure
relationship: transformation_of UBERON:0002533 ! post-anal tail bud
property_value: UBPROP:0000011 "By the fourth week a clear tail is seen in the human embryo. It recedes after a few weeks and these tissues form what is commonly known as the tailbone (coccyx)." xsd:string
@@ -230020,7 +229898,6 @@ xref: EMAPA:25127
xref: FMA:23242
xref: SCTID:368187009
xref: Wikipedia:Medial_border_of_scapula
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0007171 {source="EMAPA-modified"} ! border of scapula
relationship: has_developmental_contribution_from UBERON:0002329 {source="PMID:20136669"} ! somite
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
@@ -230120,7 +229997,6 @@ synonym: "bone marrow stroma" EXACT [FMA:21426]
xref: CALOHA:TS-0085
xref: FMA:21426
xref: Wikipedia:Bone_marrow#Stroma
-is_a: CARO:0000000 ! anatomical entity
is_a: PR:000050567 ! protein-containing material entity
is_a: UBERON:0003891 ! stroma
intersection_of: UBERON:0003891 ! stroma
@@ -230206,7 +230082,6 @@ xref: EMAPA:16271
xref: EMAPA_RETIRED:16271
xref: TAO:0000787
xref: ZFA:0000787
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0005253 {source="ZFA"} ! head mesenchyme
intersection_of: UBERON:0003104 ! mesenchyme
intersection_of: develops_from UBERON:0003099 ! cranial neural crest
@@ -230224,7 +230099,6 @@ xref: EHDAA2:0002093
xref: EMAPA:16182
xref: TAO:0000999
xref: ZFA:0000999
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0005256 ! trunk mesenchyme
intersection_of: UBERON:0003104 ! mesenchyme
intersection_of: develops_from UBERON:0003083 ! trunk neural crest
@@ -230358,7 +230232,6 @@ xref: EMAPA:36295
xref: EV:0100030
xref: FMA:14274
xref: SCTID:113261001
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0005734 ! tunica adventitia of blood vessel
intersection_of: UBERON:0005734 ! tunica adventitia of blood vessel
intersection_of: part_of UBERON:0001637 ! artery
@@ -230746,6 +230619,18 @@ intersection_of: has_potential_to_develop_into UBERON:0005075 ! forebrain-midbra
relationship: has_potential_to_develop_into UBERON:0005075 ! forebrain-midbrain boundary
relationship: part_of UBERON:0006238 ! future brain
+[Term]
+id: UBERON:0007289
+name: presumptive rhombomere 1
+namespace: uberon
+def: "A presumptive structure that has the potential to develop into a rhombomere 1." [OBOL:automatic]
+xref: TAO:0001207
+xref: ZFA:0001207
+is_a: UBERON:0006598 ! presumptive structure
+intersection_of: UBERON:0006598 ! presumptive structure
+intersection_of: has_potential_to_develop_into UBERON:0005499 ! rhombomere 1
+relationship: has_potential_to_develop_into UBERON:0005499 ! rhombomere 1
+
[Term]
id: UBERON:0007297
name: presumptive pronephric mesoderm
@@ -230892,7 +230777,6 @@ synonym: "pancreatic lobule" EXACT [FMA:16012]
xref: EMAPA:37710 {source="MA:th"}
xref: FMA:16012
xref: MA:0000721
-is_a: CARO:0000000 ! anatomical entity
is_a: PR:000050567 ! protein-containing material entity
is_a: UBERON:0000064 ! organ part
relationship: has_part UBERON:0001263 ! pancreatic acinus
@@ -231014,7 +230898,6 @@ xref: HAO:0000298
xref: TADS:0000109
xref: WBbt:0005733
xref: Wikipedia:Epidermis_(zoology)
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000483 ! epithelium
is_a: UBERON:0003102 ! surface structure
intersection_of: UBERON:0000483 ! epithelium
@@ -231035,7 +230918,6 @@ synonym: "EVL" EXACT [ZFA:0000086]
xref: EFO:0003425
xref: TAO:0000086
xref: ZFA:0000086
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000490 ! unilaminar epithelium
is_a: UBERON:0005291 ! embryonic tissue
relationship: bounding_layer_of UBERON:0000922 ! embryo
@@ -231286,7 +231168,6 @@ namespace: uberon
def: "Mesenchyme with little extracellular matrix." [AEO:JB]
xref: AEO:0000146
xref: EHDAA2:0003146
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0003104 {source="AEO"} ! mesenchyme
relationship: has_part CL:0000057 {source="AEO"} ! fibroblast
@@ -231297,7 +231178,6 @@ namespace: uberon
def: "Mesenchyme whose cells are embedded in obvious amounts of extracellular matrix." [AEO:JB]
xref: AEO:0000151
xref: EHDAA2:0003151
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0003104 {source="AEO"} ! mesenchyme
relationship: has_part CL:0000057 {source="AEO"} ! fibroblast
relationship: has_part CL:0000327 {source="AEO"} ! extracellular matrix secreting cell
@@ -231664,7 +231544,6 @@ name: uriniferous tubule
namespace: uberon
def: "Functional unit of the kidney that forms urine, consisting of two parts, the nephron and the collecting tubule." [ISBN:0073040584]
xref: FMA:17691
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0003914 ! epithelial tube
is_a: UBERON:0004819 ! kidney epithelium
is_a: UBERON:0006555 ! excretory tube
@@ -231721,7 +231600,6 @@ def: "Endodermal bud derived from the endodermal epithelium of the embryonic pha
synonym: "diverticulum thyroideum" RELATED LATIN [Wikipedia:Thyroid_diverticulum]
synonym: "saccus thyroideus" RELATED LATIN [Wikipedia:Thyroid_diverticulum]
xref: Wikipedia:Thyroid_diverticulum
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0001048 ! primordium
relationship: part_of UBERON:0001042 {source="VHOG"} ! chordate pharynx
relationship: transformation_of UBERON:0003091 ! thyroid primordium
@@ -231932,7 +231810,6 @@ xref: FMA:12276
xref: GAID:1195
xref: MESH:D005122
xref: ncithesaurus:Transudate
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0006314 ! bodily fluid
intersection_of: UBERON:0000463 ! organism substance
intersection_of: filtered_through UBERON:0001982 ! capillary
@@ -231986,7 +231863,6 @@ def: "A bridge of mesoderm connecting the caudal end of the young embryo with th
xref: BTO:0004705
xref: NCIT:C34132
xref: UMLS:C1516792 {source="ncithesaurus:Connecting_Stalk"}
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000478 {source="EHDAA2"} ! extraembryonic structure
relationship: develops_from UBERON:0005728 {source="EHDAA2"} ! extraembryonic mesoderm
property_value: editor_note "TODO - this is currently defined as a bridge of mesoderm, but in EHDAA2 is extraembryonic structure split into mesoderm and blood vessels" xsd:string
@@ -232000,7 +231876,6 @@ synonym: "connecting stalk blood vessel" RELATED []
synonym: "connecting stalk blood vessels" EXACT [EHDAA2:0000313]
synonym: "vasculature of connecting stalk" RELATED []
xref: EHDAA2:0000313
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0002049 ! vasculature
intersection_of: UBERON:0002049 ! vasculature
intersection_of: part_of UBERON:0007806 ! connecting stalk
@@ -232069,7 +231944,6 @@ xref: TAO:0001117
xref: UMLS:C0039259 {source="ncithesaurus:Tail"}
xref: XAO:0003026
xref: ZFA:0001117
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0002415 ! tail
intersection_of: UBERON:0002415 ! tail
intersection_of: part_of UBERON:0006071 ! caudal region
@@ -232097,7 +231971,6 @@ synonym: "limb girdle region" RELATED SENSU []
xref: EMAPA:37854 {source="MA:th"}
xref: FMA:24874
xref: VSAO:0000303
-is_a: CARO:0010000 ! multicellular anatomical structure
is_a: UBERON:0000475 ! organism subdivision
intersection_of: UBERON:0000475 ! organism subdivision
intersection_of: has_skeleton UBERON:0010719 ! girdle skeleton
@@ -232334,7 +232207,6 @@ name: regular connective tissue
namespace: uberon
def: "Connective tissue, which consists of fibroblasts, the intercellular matrix of which contains a regular network of collagen and elastic fiber bundles. Examples: bone (tissue), cartilage (tissue), dense regular connective tissue." [FMA:20103]
xref: FMA:20103
-is_a: CARO:0000000 ! anatomical entity
is_a: PR:000050567 ! protein-containing material entity
is_a: UBERON:0002384 {source="FMA"} ! connective tissue
disjoint_from: UBERON:0011821 ! irregular connective tissue
@@ -232657,7 +232529,6 @@ xref: MESH:D014083
xref: NCIT:C34313
xref: SCTID:53301001
xref: UMLS:C0040442 {source="ncithesaurus:Tooth_Bud"}
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0005423 ! developing anatomical structure
relationship: develops_from UBERON:0005087 ! tooth placode
relationship: part_of UBERON:0011595 {gci_relation="part_of", gci_filler="NCBITaxon:40674"} ! jaw region
@@ -233113,7 +232984,6 @@ xref: EHDAA:75
xref: EMAPA:16050
xref: NCIT:C34164
xref: UMLS:C1516906 {source="ncithesaurus:Epiblast"}
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0002532 ! epiblast (generic)
intersection_of: UBERON:0002532 ! epiblast (generic)
intersection_of: develops_from UBERON:0000087 ! inner cell mass
@@ -233672,7 +233542,6 @@ synonym: "pulmonary circulatory system" EXACT [FMA:45621]
synonym: "pulmonary system" EXACT [ISBN:0073040584]
xref: FMA:45621
xref: Wikipedia:Pulmonary_circulation
-is_a: CARO:0000006 ! material anatomical entity
is_a: PR:000050567 ! protein-containing material entity
is_a: UBERON:0007798 {source="Obol"} ! vascular system
relationship: has_part UBERON:0002012 ! pulmonary artery
@@ -233722,7 +233591,6 @@ xref: VSAO:0000149
xref: Wikipedia:Facial_skeleton
xref: XAO:0003176
xref: ZFA:0001216
-is_a: CARO:0000006 ! material anatomical entity
is_a: UBERON:0011159 ! primary subdivision of cranial skeletal system
disjoint_from: UBERON:0011156 ! facial skeleton
relationship: develops_from UBERON:0002539 {source="https://github.com/obophenotype/uberon/issues/83"} ! pharyngeal arch
@@ -234009,7 +233877,6 @@ namespace: uberon
xref: EHDAA2:0004069
xref: NCIT:C34283
xref: UMLS:C1514898 {source="ncithesaurus:Respiratory_Primordium"}
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0001048 {source="Obol"} ! primordium
relationship: has_potential_to_develop_into UBERON:0001004 ! respiratory system
relationship: part_of UBERON:0003258 ! endoderm of foregut
@@ -234437,7 +234304,6 @@ xref: EFO:0000229
xref: TAO:0001198
xref: XAO:0004208
xref: ZFA:0001198
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0002546 ! cranial placode
is_a: UBERON:0011814 {source="NCBIBook:NBK53175"} ! non-neurogenic ectodermal placode
relationship: develops_from UBERON:0005497 {source="ZFA"} ! non-neural ectoderm
@@ -234578,7 +234444,6 @@ def: "Sum total of mesenchyme in the embryo." [https://github.com/obophenotype/h
xref: EHDAA2:0001113
xref: EHDAA:177
xref: EMAPA:16097
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000477 ! anatomical cluster
relationship: composed_primarily_of UBERON:0003104 ! mesenchyme
relationship: has_developmental_contribution_from UBERON:0000926 {source="EHDAA2"} ! mesoderm
@@ -234755,7 +234620,6 @@ xref: EMAPA:32749
xref: FMA:295758
xref: NCIT:C34251
xref: UMLS:C1519040 {source="ncithesaurus:Pharyngeal_Membrane"}
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0002050 ! embryonic structure
relationship: has_part UBERON:0000924 ! ectoderm
relationship: has_part UBERON:0000925 ! endoderm
@@ -235340,7 +235204,6 @@ synonym: "spinal cord lumen" EXACT [EMAPA:25042]
xref: EMAPA:25042
xref: FMA:242845
xref: Wikipedia:Central_canal
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000464 ! anatomical space
intersection_of: UBERON:0000464 ! anatomical space
intersection_of: luminal_space_of UBERON:0002291 ! central canal of spinal cord
@@ -235356,7 +235219,6 @@ namespace: uberon
def: "A sulcus limitans of neural tube that is part of a future medulla oblongata." [OBOL:automatic]
xref: EHDAA2:0001100
xref: EMAPA:17561
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0005478 ! sulcus limitans of neural tube
intersection_of: UBERON:0005478 ! sulcus limitans of neural tube
intersection_of: part_of UBERON:0001896 ! medulla oblongata
@@ -235885,7 +235747,6 @@ xref: EHDAA2:0004587
xref: EMAPA:18388
xref: FMA:14598
xref: SCTID:259740004
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000464 ! anatomical space
intersection_of: UBERON:0000464 ! anatomical space
intersection_of: luminal_space_of UBERON:0001052 ! rectum
@@ -235906,7 +235767,6 @@ xref: EHDAA2:0001981
xref: EHDAA:1993
xref: EHDAA:2671
xref: EMAPA:16914
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0013150 ! future brain vesicle
relationship: develops_from UBERON:0006284 {source="EHDAA2"} ! early prosencephalic vesicle
relationship: part_of UBERON:0001893 {source="EHDAA2"} ! telencephalon
@@ -235973,7 +235833,6 @@ synonym: "epithelium of vermiform appendix" EXACT [FMA:63581]
xref: CALOHA:TS-2062
xref: EHDAA2:0004561
xref: FMA:63581
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0001278 ! epithelium of large intestine
intersection_of: UBERON:0000483 ! epithelium
intersection_of: part_of UBERON:0001154 ! vermiform appendix
@@ -236026,7 +235885,6 @@ xref: FMA:9536
xref: NCIT:C102343
xref: SCTID:8911002
xref: VHOG:0001235
-is_a: CARO:0010000 ! multicellular anatomical structure
is_a: UBERON:0001081 ! endocardium of ventricle
intersection_of: UBERON:0001081 ! endocardium of ventricle
intersection_of: part_of UBERON:0002080 ! heart right ventricle
@@ -236049,7 +235907,6 @@ xref: EMAPA:17338
xref: FMA:9559
xref: SCTID:191004004
xref: VHOG:0001233
-is_a: CARO:0010000 ! multicellular anatomical structure
is_a: UBERON:0001081 ! endocardium of ventricle
intersection_of: UBERON:0001081 ! endocardium of ventricle
intersection_of: part_of UBERON:0002084 ! heart left ventricle
@@ -236069,7 +235926,6 @@ xref: EHDAA2:0000868
xref: EHDAA:7856
xref: FMA:295872
xref: Wikipedia:Intermaxillary_segment
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0009292 {source="EHDAA2-modified"} ! embryonic nasal process
relationship: develops_from UBERON:0004067 {notes="inconsistent", source="EHDAA2"} ! lateral nasal prominence
relationship: develops_from UBERON:0004068 {source="EHDAA2"} ! medial nasal prominence
@@ -236381,6 +236237,26 @@ relationship: in_lateral_side_of UBERON:0001004 {source="FMA-abduced-lr"} ! resp
relationship: part_of UBERON:0001558 {source="FMA"} ! lower respiratory tract
property_value: UBPROP:0000012 "despite its name the class EHDAA2:0004737 is not a true cavity, it corresponds to what we call the sac" xsd:string {external_ontology="EHDAA2"}
+[Term]
+id: UBERON:0009841
+name: upper rhombic lip
+namespace: uberon
+def: "Anterior-most region of dorsal hindbrain within rhombomere 1, adjacent the midbrain-hindbrain boundary." [ZFIN:curator]
+subset: pheno_slim
+synonym: "cerebellar anlage" EXACT [ZFA:0001442]
+synonym: "presumptive cerebellum" EXACT [ZFA:0001442]
+synonym: "rhombomere 01 cerebellum primordium" RELATED [EHDAA2:0000229]
+synonym: "rostral rhombic lip" EXACT [DHB:URL]
+synonym: "upper (rostral) rhombic lip" EXACT []
+xref: DHBA:10665
+xref: EHDAA2:0000229
+xref: TAO:0001442
+xref: ZFA:0001442
+is_a: UBERON:0002616 ! regional part of brain
+relationship: adjacent_to UBERON:0003052 {source="ZFA-def"} ! midbrain-hindbrain boundary
+relationship: part_of UBERON:0005499 {source="ZFA"} ! rhombomere 1
+relationship: part_of UBERON:0006215 {source="ZFA"} ! rhombic lip
+
[Term]
id: UBERON:0009842
name: glandular acinus
@@ -236409,7 +236285,6 @@ def: "A solid cord of prostate epithelium." [GO:0060527, OBOL:automatic, PMID:18
comment: Complexity is conferred on the prostate during a postnatal development phase known as branching morphogenesis. Solid cords of prostate epithelium formed in utero elongate postnatally and their tips are bifurcated into primary, secondary, and tertiary branches in a pattern that is unique for each prostate lobe. Branching morphogenesis proceeds differentially for each of the three mouse prostate lobes (ventral, dorsolateral, and anterior) and is completed by about postnatal day 20 in mice, providing each lobe with unique glandular architecture [5]. It is important to note that the developing human prostate undergoes a similar series of morphogenetic events especially during prostatic bud formation, but gives rise to a mature glandular prostate that is unique from the rodent and features peripheral, central, and transitional zones[PMID:18977204]
synonym: "cord of prostate epithelium" EXACT [PMID:18977204]
synonym: "epithelial cord of prostate" EXACT []
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0005154 ! epithelial cord
intersection_of: UBERON:0005154 ! epithelial cord
intersection_of: has_potential_to_develop_into UBERON:0002367 ! prostate gland
@@ -236421,7 +236296,6 @@ name: urogenital sinus lumen
namespace: uberon
def: "An anatomical space that surrounded_by a primitive urogenital sinus." [OBOL:automatic]
xref: EHDAA2:0002142
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000464 ! anatomical space
intersection_of: UBERON:0000464 ! anatomical space
intersection_of: luminal_space_of UBERON:0000164 ! primitive urogenital sinus
@@ -236465,7 +236339,6 @@ name: prostate field
namespace: uberon
def: "A specific region of the urogenital sinus epithelium into the area in which the prostate gland will develop." [GO:0060515, GOC:dph, PMID:18977204]
synonym: "prostate primordium" RELATED []
-is_a: CARO:0000006 ! material anatomical entity
is_a: UBERON:0005291 ! embryonic tissue
is_a: UBERON:0006598 ! presumptive structure
is_a: UBERON:0007688 ! anlage
@@ -236595,7 +236468,6 @@ synonym: "metacarpus/metatarsus region" EXACT []
synonym: "metapodial segment" EXACT []
synonym: "metapodium" RELATED []
xref: SCTID:370640001
-is_a: CARO:0010000 ! multicellular anatomical structure
is_a: UBERON:0002529 ! limb segment
intersection_of: UBERON:0002529 ! limb segment
intersection_of: has_skeleton UBERON:0010546 ! metapodial skeleton
@@ -236618,7 +236490,6 @@ synonym: "mesopodium" RELATED [VSAO:0005022, VSAO:NI]
synonym: "mesopodium skeleton" EXACT [https://orcid.org/0000-0002-6601-2165]
synonym: "skeletal parts of mesopodium" EXACT [https://orcid.org/0000-0002-6601-2165]
xref: VSAO:0005022
-is_a: CARO:0010000 ! multicellular anatomical structure
is_a: UBERON:0010712 ! limb skeleton subdivision
intersection_of: UBERON:0010912 ! subdivision of skeleton
intersection_of: skeleton_of UBERON:0006716 ! mesopodium region
@@ -236927,7 +236798,6 @@ synonym: "renunculus" RELATED [http://www.mondofacto.com/facts/dictionary?lobus+
xref: FMA:17670
xref: SCTID:361330004
xref: Wikipedia:Cortical_lobule
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0009911 ! lobule
intersection_of: UBERON:0009911 ! lobule
intersection_of: part_of UBERON:0002113 ! kidney
@@ -236944,7 +236814,6 @@ def: "An anatomical wall that is part of a ureter." [OBOL:automatic]
synonym: "ureteral wall" EXACT [FMA:15888]
xref: FMA:15888
xref: SCTID:279397004
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000060 ! anatomical wall
intersection_of: UBERON:0000060 ! anatomical wall
intersection_of: part_of UBERON:0000056 ! ureter
@@ -237056,7 +236925,6 @@ xref: TAO:0001309
xref: Wikipedia:Neurogenic_placodes
xref: XAO:0004620
xref: ZFA:0001309
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0002546 {source="cjm"} ! cranial placode
intersection_of: UBERON:0005085 ! ectodermal placode
intersection_of: has_potential_to_developmentally_contribute_to CL:0000540 ! neuron
@@ -237083,7 +236951,6 @@ xref: EHDAA2:0004058
xref: FMA:15924
xref: galen:UrinaryBladderCavity
xref: SCTID:279405003
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000464 ! anatomical space
intersection_of: UBERON:0000464 {source="FMA"} ! anatomical space
intersection_of: luminal_space_of UBERON:0001255 {source="FMA"} ! urinary bladder
@@ -237302,7 +237169,6 @@ subset: non_informative
synonym: "set of nuclei of neuraxis" RELATED [FMA:256381]
xref: FMA:256381
xref: NLXANAT:20090509
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0034923 ! disconnected anatomical group
intersection_of: UBERON:0034923 ! disconnected anatomical group
intersection_of: has_member UBERON:0002616 ! regional part of brain
@@ -237473,7 +237339,6 @@ xref: FMA:229084
xref: NCIT:C32130
xref: UMLS:C0226946 {source="ncithesaurus:Apex_of_the_Tongue"}
xref: Wikipedia:Anterior_tongue
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000064 ! organ part
intersection_of: UBERON:0000064 {source="ISBN:1607950324"} ! organ part
intersection_of: develops_from UBERON:0006260 {source="ISBN:1607950324"} ! lingual swellings
@@ -237659,7 +237524,6 @@ id: UBERON:0010065
name: auditory meatus epithelium
namespace: uberon
xref: EHDAA2:0004114
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0003914 {source="EHDAA2"} ! epithelial tube
is_a: UBERON:0015814 ! outer ear epithelium
relationship: develops_from UBERON:0005872 {source="EHDAA2", source="PMID:16313389"} ! 1st arch pharyngeal cleft
@@ -237767,7 +237631,6 @@ name: future dermis
namespace: uberon
def: "Mesenchyme that has the potential to develop into a dermis." [OBOL:automatic]
xref: EHDAA2:0000598
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0003104 ! mesenchyme
intersection_of: UBERON:0003104 ! mesenchyme
intersection_of: has_potential_to_develop_into UBERON:0002067 ! dermis
@@ -237783,7 +237646,6 @@ name: future diaphragm
namespace: uberon
def: "A structure that will develop into a diaphragm." [http://orcid.org/0000-0002-6601-2165]
xref: EHDAA2:0000599
-is_a: CARO:0000006 ! material anatomical entity
is_a: UBERON:0006598 ! presumptive structure
intersection_of: UBERON:0006598 ! presumptive structure
intersection_of: has_potential_to_develop_into UBERON:0001103 ! diaphragm
@@ -237837,7 +237699,6 @@ name: future facial nucleus
namespace: uberon
def: "A gray matter that has the potential to develop into a facial nucleus." [OBOL:automatic]
xref: EHDAA2:0004639
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0002020 ! gray matter
intersection_of: UBERON:0002020 ! gray matter
intersection_of: has_potential_to_develop_into UBERON:0000127 ! facial nucleus
@@ -237849,7 +237710,6 @@ name: future superior salivatory nucleus
namespace: uberon
def: "A gray matter that has the potential to develop into a superior salivatory nucleus." [OBOL:automatic]
xref: EHDAA2:0004644
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0002020 ! gray matter
intersection_of: UBERON:0002020 ! gray matter
intersection_of: has_potential_to_develop_into UBERON:0002149 ! superior salivatory nucleus
@@ -238092,7 +237952,6 @@ synonym: "hairs set" EXACT [FMA:70752]
synonym: "pili" EXACT LATIN [FMA:TA]
synonym: "set of hairs" EXACT [FMA:70752]
xref: FMA:70752
-is_a: CARO:0000006 ! material anatomical entity
is_a: UBERON:0034925 ! anatomical collection
intersection_of: UBERON:0034925 ! anatomical collection
intersection_of: has_member UBERON:0001037 ! strand of hair
@@ -238298,7 +238157,6 @@ synonym: "thrombus" EXACT [BTO:0000102]
xref: BTO:0000102
xref: galen:BloodClot
xref: Wikipedia:Thrombus
-is_a: CARO:0000000 ! anatomical entity
is_a: PR:000050567 ! protein-containing material entity
is_a: UBERON:0000463 ! organism substance
intersection_of: UBERON:0000463 ! organism substance
@@ -238318,7 +238176,6 @@ def: "Apparatus located between the lungs and the buccal cavity. This apparatus
synonym: "laryngeal cartilage system" EXACT [EHDAA2:0000904]
xref: AAO:0000267
xref: EHDAA2:0000904
-is_a: CARO:0000006 ! material anatomical entity
is_a: UBERON:0034921 ! multi organ part structure
relationship: composed_primarily_of UBERON:0001739 ! laryngeal cartilage
relationship: part_of UBERON:0001737 {source="EHDAA2"} ! larynx
@@ -238721,7 +238578,6 @@ id: UBERON:0010299
name: scleral mesenchyme
namespace: uberon
def: "Mesenchyme surrounding the developing optic cup which develops into the sclera." [https://orcid.org/0000-0002-6601-2165, PMID:16496288]
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0003104 ! mesenchyme
intersection_of: UBERON:0003104 ! mesenchyme
intersection_of: has_potential_to_develop_into UBERON:0001773 ! sclera
@@ -238794,7 +238650,6 @@ def: "Developing anatomical structure that develops into the eyeball and associa
synonym: "future eye" EXACT []
xref: TAO:0002201
xref: ZFA:0001678
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0005423 ! developing anatomical structure
intersection_of: UBERON:0005423 ! developing anatomical structure
intersection_of: has_developmental_contribution_from UBERON:0003071 ! eye primordium
@@ -238821,7 +238676,6 @@ name: structure with developmental contribution from neural crest
namespace: uberon
def: "An anatomical structure that has some part that develops from the neural crest." [https://orcid.org/0000-0002-6601-2165]
subset: grouping_class
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000061 ! anatomical structure
intersection_of: UBERON:0000061 ! anatomical structure
intersection_of: has_developmental_contribution_from UBERON:0002342 ! neural crest
@@ -238832,7 +238686,6 @@ property_value: IAO:0000232 "Grouping term for query purposes" xsd:string
id: UBERON:0010316
name: germ layer / neural crest
namespace: uberon
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0002050 ! embryonic structure
is_a: UBERON:0005291 ! embryonic tissue
relationship: develops_from UBERON:0002532 ! epiblast (generic)
@@ -238915,7 +238768,6 @@ def: "An epithelium that is part of a handplate." [OBOL:automatic]
synonym: "handplate epithelium" EXACT [EHDAA2:0000730]
xref: EHDAA2:0000730
xref: EMAPA:32630
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000490 {source="EHDAA2"} ! unilaminar epithelium
is_a: UBERON:0005291 ! embryonic tissue
intersection_of: UBERON:0000483 ! epithelium
@@ -239600,7 +239452,6 @@ synonym: "brain marginal zone" BROAD [MA:0000812]
xref: DHBA:10508
xref: EMAPA:32680
xref: MA:0000812
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0005423 ! developing anatomical structure
relationship: develops_from UBERON:0004062 ! neural tube marginal layer
relationship: part_of UBERON:0000955 ! brain
@@ -239730,7 +239581,6 @@ synonym: "primary follicle" RELATED []
synonym: "primary lymphoid follicle" EXACT []
synonym: "primary lymphoid nodule" EXACT [FMA:55223]
xref: FMA:55223
-is_a: CARO:0000006 ! material anatomical entity
is_a: UBERON:0000444 {source="FMA"} ! lymphoid follicle
relationship: has_part CL:0000788 {source="CL:tm"} ! naive B cell
property_value: UBPROP:0000015 "The cortex of lymph nodes, the white pulp of spleen, and mucosa associated lymphoid tissue all have these primary follicles" xsd:string
@@ -239909,7 +239759,6 @@ xref: EMAPA:17953
xref: EMAPA:27621
xref: MA:0002998
xref: VHOG:0001241
-is_a: CARO:0000006 ! material anatomical entity
is_a: UBERON:0005423 ! developing anatomical structure
relationship: developmentally_induced_by UBERON:0000084 ! ureteric bud
relationship: develops_from UBERON:0003220 {source="EHDAA2"} ! metanephric mesenchyme
@@ -239926,7 +239775,6 @@ synonym: "developing nephron" BROAD []
synonym: "future nephron" EXACT []
synonym: "presumptive nephron" EXACT []
synonym: "primitive nephron" BROAD []
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0003914 {source="EHDAA2-inferred"} ! epithelial tube
is_a: UBERON:0004819 ! kidney epithelium
is_a: UBERON:0006555 ! excretory tube
@@ -239980,7 +239828,6 @@ relationship: part_of UBERON:0005113 {source="EHDAA2"} ! metanephric cortex mese
id: UBERON:0010536
name: nephron progenitor
namespace: uberon
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000479 {source="ZFA"} ! tissue
relationship: has_potential_to_develop_into UBERON:0001285 ! nephron
relationship: part_of UBERON:0003918 {source="cjm"} ! kidney mesenchyme
@@ -240059,7 +239906,6 @@ synonym: "skeletal parts of acropodium" RELATED []
synonym: "skeleton of digits" RELATED []
xref: FMA:231315
xref: VSAO:0005028
-is_a: CARO:0010000 ! multicellular anatomical structure
is_a: UBERON:0010712 ! limb skeleton subdivision
intersection_of: UBERON:0010912 ! subdivision of skeleton
intersection_of: skeleton_of UBERON:0012354 ! acropodium region
@@ -240152,7 +239998,6 @@ synonym: "metapodium skeleton" EXACT [https://orcid.org/0000-0002-6601-2165]
synonym: "skeletal parts of metapodium" EXACT [https://orcid.org/0000-0002-6601-2165]
synonym: "skeleton of metapodium" EXACT []
xref: VSAO:0005025
-is_a: CARO:0010000 ! multicellular anatomical structure
is_a: UBERON:0010712 ! limb skeleton subdivision
intersection_of: UBERON:0010912 ! subdivision of skeleton
intersection_of: skeleton_of UBERON:0009877 ! metapodium region
@@ -240471,7 +240316,6 @@ xref: EMAPA:37860 {source="MA:th"}
xref: FMA:7183
xref: SCTID:110716002
xref: VSAO:0000213
-is_a: CARO:0010000 ! multicellular anatomical structure
is_a: UBERON:0010707 ! appendage girdle complex
intersection_of: UBERON:0010707 ! appendage girdle complex
intersection_of: has_part UBERON:0001421 ! pectoral girdle region
@@ -240497,7 +240341,6 @@ xref: EMAPA:37863 {source="MA:th"}
xref: FMA:7184
xref: SCTID:416631005
xref: VSAO:0000215
-is_a: CARO:0010000 ! multicellular anatomical structure
is_a: UBERON:0010707 ! appendage girdle complex
intersection_of: UBERON:0010707 ! appendage girdle complex
intersection_of: has_part UBERON:0001271 ! pelvic girdle region
@@ -240545,7 +240388,6 @@ def: "The subdivision of the skeleton of either the pectoral or pelvic girdle."
synonym: "skeleton of girdle" EXACT []
xref: AAO:0010686
xref: VSAO:0000302
-is_a: CARO:0010000 ! multicellular anatomical structure
is_a: UBERON:0010912 ! subdivision of skeleton
intersection_of: UBERON:0010912 ! subdivision of skeleton
intersection_of: skeleton_of UBERON:0007823 ! appendage girdle region
@@ -240666,7 +240508,6 @@ xref: neuronames:1465
xref: SCTID:362879001
xref: UMLS:C0228116
xref: Wikipedia:Meninges
-is_a: CARO:0000006 ! material anatomical entity
is_a: PR:000050567 ! protein-containing material entity
is_a: UBERON:0034925 ! anatomical collection
intersection_of: UBERON:0034925 ! anatomical collection
@@ -241013,7 +240854,6 @@ xref: BILA:0000046
xref: CARO:0000046
xref: HAO:0000046
xref: TADS:0000609
-is_a: CARO:0000006 ! material anatomical entity
is_a: UBERON:0007197 {source="CARO"} ! hermaphroditic organism
intersection_of: UBERON:0000468 ! multicellular organism
intersection_of: has_part UBERON:0000473 ! testis
@@ -241029,7 +240869,6 @@ def: "A primordium that develops into a clavicle bone." [https://github.com/obop
comment: lateral part derives from a fish dermal bone while the medial part comes from a spur off the manubrium endochondral bone[JB]
synonym: "clavicle primordium" EXACT []
xref: EHDAA2:0000254
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0001048 ! primordium
intersection_of: UBERON:0001048 ! primordium
intersection_of: has_potential_to_develop_into UBERON:0001105 ! clavicle bone
@@ -241284,7 +241123,6 @@ xref: EFO:0003659
xref: TAO:0001272
xref: VHOG:0000511
xref: ZFA:0001272
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0010912 {source="cjm"} ! subdivision of skeleton
relationship: develops_from UBERON:0004362 ! pharyngeal arch 1
relationship: part_of UBERON:0003277 ! skeleton of upper jaw
@@ -241397,7 +241235,6 @@ xref: FMA:52628
xref: NCIT:C32908
xref: SCTID:280218007
xref: Wikipedia:Lacrimal_nerve
-is_a: CARO:0001001 ! neuron projection bundle
is_a: UBERON:0001021 ! nerve
intersection_of: UBERON:0001021 ! nerve
intersection_of: innervates UBERON:0001817 ! lacrimal gland
@@ -241618,7 +241455,6 @@ name: axial skeletal system
namespace: uberon
def: "Subdivision of the skeletal system which consists of the axial skeleton plus associated joints." [https://orcid.org/0000-0002-6601-2165]
xref: FMA:7483
-is_a: CARO:0000006 ! material anatomical entity
is_a: UBERON:0000075 {source="FMA"} ! subdivision of skeletal system
relationship: has_part UBERON:0000982 ! skeletal joint
relationship: has_part UBERON:0005944 ! axial skeleton plus cranial skeleton
@@ -241632,7 +241468,6 @@ def: "Subdivision of the skeletal system which consists of the postcranial axial
synonym: "axial skeletal system" BROAD [https://github.com/obophenotype/uberon/wiki/The-axial-skeleton]
synonym: "post-cranial axial skeletal system" EXACT []
xref: FMA:302077
-is_a: CARO:0000006 ! material anatomical entity
is_a: UBERON:0000075 {source="FMA"} ! subdivision of skeletal system
relationship: develops_from UBERON:0003089 {source="cjm"} ! sclerotome
property_value: seeAlso "http://purl.obolibrary.org/obo/uberon/docs/The-axial-skeleton" xsd:anyURI
@@ -241689,7 +241524,6 @@ xref: FMA:45658
xref: galen:UpperUrinaryTract
xref: NCIT:C61107
xref: SCTID:181413006
-is_a: CARO:0000006 ! material anatomical entity
is_a: UBERON:0011216 ! organ system subdivision
is_a: UBERON:0015212 ! lateral structure
relationship: has_part UBERON:0000056 ! ureter
@@ -241728,7 +241562,6 @@ xref: EMAPA:18022
xref: FMA:53673
xref: MA:0000318
xref: Wikipedia:Facial_skeleton
-is_a: CARO:0000006 ! material anatomical entity
is_a: UBERON:0010313 ! neural crest-derived structure
is_a: UBERON:0011158 {source="FMA"} ! primary subdivision of skull
relationship: part_of UBERON:0001456 {source="FMA"} ! face
@@ -242030,7 +241863,6 @@ name: ethmoid region
namespace: uberon
def: "The most anterior region of the braincase. Provides structural support for peripheral olfactory organ." [http://palaeos.com/vertebrates/bones/braincase/ethmoid.html, UBERONREF:0000007]
xref: AAO:0000986
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0034921 ! multi organ part structure
relationship: has_developmental_contribution_from UBERON:0005945 ! neurocranial trabecula
relationship: part_of UBERON:0003112 ! olfactory region
@@ -242086,7 +241918,6 @@ namespace: uberon
synonym: "basal cell layer of skin" RELATED []
synonym: "outer epithelium of body" RELATED [Wikipathways:WP2062]
xref: EHDAA2:0001845
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000490 {source="EHDAA2"} ! unilaminar epithelium
relationship: develops_from UBERON:0000076 {source="EHDAA2"} ! external ectoderm
relationship: part_of UBERON:0002199 {source="EHDAA2"} ! integument
@@ -242323,7 +242154,6 @@ synonym: "limb/fin skeleton" EXACT [VSAO:0000301]
synonym: "skeletal parts of limb/fin" EXACT []
synonym: "skeleton of limb/fin" EXACT []
xref: VSAO:0000301
-is_a: CARO:0010000 ! multicellular anatomical structure
is_a: UBERON:0004120 ! mesoderm-derived structure
is_a: UBERON:0010912 ! subdivision of skeleton
intersection_of: UBERON:0010912 ! subdivision of skeleton
@@ -242347,7 +242177,6 @@ synonym: "stylopod" RELATED [VSAO:0005007]
synonym: "stylopodium" RELATED []
synonym: "stylopodium skeleton" EXACT []
xref: VSAO:0005007
-is_a: CARO:0010000 ! multicellular anatomical structure
is_a: UBERON:0010712 ! limb skeleton subdivision
intersection_of: UBERON:0010912 ! subdivision of skeleton
intersection_of: skeleton_of UBERON:0002472 ! stylopod
@@ -242372,7 +242201,6 @@ synonym: "skeleton of zeugopod" EXACT [https://orcid.org/0000-0002-6601-2165]
synonym: "zeugopod skeleton" EXACT [https://orcid.org/0000-0002-6601-2165]
synonym: "zygopodium" RELATED [VSAO:0005010]
xref: VSAO:0005010
-is_a: CARO:0010000 ! multicellular anatomical structure
is_a: UBERON:0010712 ! limb skeleton subdivision
intersection_of: UBERON:0010912 ! subdivision of skeleton
intersection_of: skeleton_of UBERON:0002471 ! zeugopod
@@ -242449,7 +242277,6 @@ name: future upper lip
namespace: uberon
synonym: "upper jaw future lip" EXACT [EHDAA2:0002120]
xref: EHDAA2:0002120
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000490 {source="EHDAA2"} ! unilaminar epithelium
is_a: UBERON:0003235 ! epithelium of upper jaw
relationship: develops_from UBERON:0004068 {notes="fusion"} ! medial nasal prominence
@@ -242483,7 +242310,6 @@ namespace: uberon
def: "A subdivision of the head that corresponds to the jaw skeleton, containing both soft tissue, skeleton and teeth (when present). The jaw region is divided into upper and lower regions." [http://orcid.org/0000-0002-6601-2165]
xref: EMAPA:32905
xref: NCIT:C114916
-is_a: CARO:0010000 ! multicellular anatomical structure
is_a: UBERON:0000475 ! organism subdivision
intersection_of: UBERON:0000475 ! organism subdivision
intersection_of: has_skeleton UBERON:0001708 ! jaw skeleton
@@ -242498,7 +242324,6 @@ name: future lower lip
namespace: uberon
synonym: "lower jaw future lip" EXACT [EHDAA2:0001020]
xref: EHDAA2:0001020
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000490 {source="EHDAA2"} ! unilaminar epithelium
is_a: UBERON:0003236 ! epithelium of lower jaw
relationship: develops_from UBERON:0005867 {source="Wikipedia:Mandibular_prominence"} ! mandibular prominence
@@ -242702,7 +242527,6 @@ synonym: "primordial phallus" RELATED [Wikipedia:Primordial_phallus]
xref: NCIT:C34274
xref: UMLS:C1514448 {source="ncithesaurus:Primordial_Phallus"}
xref: Wikipedia:Primordial_phallus
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0005423 ! developing anatomical structure
union_of: UBERON:0006233 ! female genital tubercle
union_of: UBERON:0006261 ! male genital tubercle
@@ -242751,7 +242575,6 @@ def: "Anatomical projection that is composed of cartilage tissue." [VSAO:wd]
synonym: "cartilage process" EXACT []
synonym: "cartilaginous process" EXACT []
xref: FMA:284626
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0004529 ! anatomical projection
intersection_of: UBERON:0004529 ! anatomical projection
intersection_of: composed_primarily_of UBERON:0002418 ! cartilage tissue
@@ -243136,7 +242959,6 @@ synonym: "vasculosa oculi" RELATED [MP:0005194]
synonym: "ventral uveal tract" EXACT []
xref: EMAPA:37417 {source="MA:th"}
xref: SCTID:280656002
-is_a: CARO:0000006 ! material anatomical entity
is_a: UBERON:0000481 {source="ZFA"} ! multi-tissue structure
relationship: contributes_to_morphology_of UBERON:0001768 ! uvea
relationship: contributes_to_morphology_of UBERON:0001801 ! anterior segment of eyeball
@@ -243296,7 +243118,6 @@ synonym: "pilosebaceous gland" RELATED [FMA:70661]
xref: EMAPA:36582
xref: FMA:70661
xref: Wikipedia:Pilosebaceous_unit
-is_a: CARO:0000006 ! material anatomical entity
is_a: PR:000050567 ! protein-containing material entity
is_a: UBERON:0000063 ! organ subunit
relationship: has_part UBERON:0001821 ! sebaceous gland
@@ -243748,7 +243569,6 @@ name: digitopodium region
namespace: uberon
def: "A segment of the autopod consisting of both acropodial region and metapodial region, but excluding the mesopodial/basopodial region." [https://github.com/obophenotype/uberon/issues/131, PHENOSCAPE:ni]
synonym: "acropodium (Wagner)" RELATED []
-is_a: CARO:0010000 ! multicellular anatomical structure
is_a: UBERON:0012139 ! segment of autopod
intersection_of: UBERON:0012139 ! segment of autopod
intersection_of: has_skeleton UBERON:0012150 ! skeleton of digitopodium
@@ -243790,7 +243610,6 @@ namespace: uberon
def: "A subdivision of the autopod skeleton consisting of both acropodial skeleon and metapodial skeleton, but excluding the mesopodial/basopodial skeleton." [PHENOSCAPE:ni]
synonym: "digitopodium" RELATED [PHENOSCAPE:ni]
synonym: "skeleton of digits" RELATED COMPARATIVE_PREFERRED []
-is_a: CARO:0010000 ! multicellular anatomical structure
is_a: UBERON:0010712 ! limb skeleton subdivision
intersection_of: UBERON:0010912 ! subdivision of skeleton
intersection_of: skeleton_of UBERON:0012140 ! digitopodium region
@@ -243859,7 +243678,6 @@ synonym: "stomach endoderm" RELATED [EFO:0002580]
xref: EFO:0002580
xref: NCIT:C34305
xref: UMLS:C1514976 {source="ncithesaurus:Stomach_Primordium"}
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0001048 ! primordium
intersection_of: UBERON:0001048 ! primordium
intersection_of: has_potential_to_develop_into UBERON:0000945 ! stomach
@@ -244297,7 +244115,6 @@ namespace: uberon
synonym: "ectoderm of maxillary component" EXACT [EMAPA:16389]
xref: EHDAA2:0000039
xref: EMAPA:16389
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000490 {source="EHDAA2"} ! unilaminar epithelium
is_a: UBERON:0005291 ! embryonic tissue
is_a: UBERON:0015833 ! foregut epithelium
@@ -244466,7 +244283,6 @@ synonym: "acropodial limb segment" EXACT []
synonym: "acropodial region" EXACT []
synonym: "acropodial segment of autopod" EXACT []
synonym: "set of digits" EXACT []
-is_a: CARO:0010000 ! multicellular anatomical structure
is_a: UBERON:0012139 ! segment of autopod
intersection_of: UBERON:0012139 ! segment of autopod
intersection_of: has_skeleton UBERON:0010543 ! acropodial skeleton
@@ -244660,7 +244476,6 @@ xref: NCIT:C94494
xref: SCTID:2255006
xref: UMLS:C0225334 {source="ncithesaurus:Subserosa"}
xref: Wikipedia:Subserosa
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0004923 ! organ component layer
intersection_of: UBERON:0004923 ! organ component layer
intersection_of: adjacent_to UBERON:0000042 ! serous membrane
@@ -244899,7 +244714,6 @@ synonym: "tunica fibrosa" BROAD []
xref: FMA:58102
xref: SCTID:361318005
xref: Wikipedia:Fibrous_tunic_of_eyeball
-is_a: CARO:0000006 ! material anatomical entity
is_a: PR:000050567 ! protein-containing material entity
is_a: UBERON:0004923 {source="FMA"} ! organ component layer
is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
@@ -245026,7 +244840,6 @@ synonym: "set of bones of upper limb" RELATED [FMA:24139]
synonym: "skeleton of anterior limb/fin and girdle" RELATED [https://orcid.org/0000-0002-6601-2165]
synonym: "upper limb skeleton" RELATED [FMA:24139]
xref: FMA:24139
-is_a: CARO:0010000 ! multicellular anatomical structure
is_a: UBERON:0010912 ! subdivision of skeleton
intersection_of: UBERON:0010912 ! subdivision of skeleton
intersection_of: skeleton_of UBERON:0010708 ! pectoral complex
@@ -245047,7 +244860,6 @@ synonym: "pelvic complex skeleton" RELATED [https://orcid.org/0000-0002-6601-216
synonym: "set of bones of lower limb" RELATED [FMA:24140]
synonym: "skeleton of posterior limb/fin and girdle" RELATED [https://orcid.org/0000-0002-6601-2165]
xref: FMA:24140
-is_a: CARO:0010000 ! multicellular anatomical structure
is_a: UBERON:0010912 ! subdivision of skeleton
intersection_of: UBERON:0010912 ! subdivision of skeleton
intersection_of: skeleton_of UBERON:0010709 ! pelvic complex
@@ -245696,7 +245508,6 @@ relationship: part_of UBERON:0000409 ! serous gland
id: UBERON:0013238
name: future glans
namespace: uberon
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0005423 ! developing anatomical structure
union_of: UBERON:0013239 ! future glans penis
union_of: UBERON:0013240 ! future glans clitoris
@@ -245737,7 +245548,6 @@ synonym: "urethral groove" EXACT []
synonym: "urethral sulcus" EXACT []
xref: SCTID:361531004
xref: Wikipedia:Urethral_groove
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0002050 ! embryonic structure
relationship: develops_from UBERON:0004876 {source="Wikipedia"} ! urogenital fold
property_value: UBPROP:0000008 "In humans, the urethral groove is a temporary linear indentation on the underside (ventral side) of the male penis during embryonic development. It typically appears around 8 weeks of gestation and becomes closed into a normal male urethra by the 12th week" xsd:string {source="Wikipedia:Urethral_groove"}
@@ -246119,7 +245929,6 @@ def: "An anatomical cavity that is part of a ear vesicle." [OBOL:automatic]
synonym: "lumen of otocyst" EXACT [EMAPA:25363]
xref: EHDAA2:0004121
xref: EMAPA:25363
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0002553 ! anatomical cavity
is_a: UBERON:0007473 {source="EHDAA2"} ! lumen of epithelial sac
intersection_of: UBERON:0002553 ! anatomical cavity
@@ -246150,7 +245959,6 @@ synonym: "strata magnocellularia nuclei dorsalis corporis geniculati lateralis"
xref: DHBA:10431
xref: FMA:76989
xref: PBA:128013078
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0013605 ! layer of lateral geniculate body
intersection_of: UBERON:0013605 ! layer of lateral geniculate body
intersection_of: composed_primarily_of CL:0011003 ! magnocellular neurosecretory cell
@@ -246167,7 +245975,6 @@ synonym: "strata parvocellularia" BROAD []
synonym: "strata parvocellularia nuclei dorsalis corporis geniculati lateralis" EXACT LATIN [FMA:76992, FMA:TA]
xref: FMA:76992
xref: PBA:128013091
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0013605 ! layer of lateral geniculate body
intersection_of: UBERON:0013605 ! layer of lateral geniculate body
intersection_of: composed_primarily_of CL:1001505 ! parvocellular neurosecretory cell
@@ -246442,7 +246249,6 @@ namespace: uberon
def: "Musculature of the head and neck, spine, and ribs." [HP:0003327]
xref: EHDAA2:0000159
xref: EMAPA:18166
-is_a: CARO:0010000 ! multicellular anatomical structure
is_a: UBERON:0001015 ! musculature
intersection_of: UBERON:0001015 ! musculature
intersection_of: attaches_to UBERON:0005944 ! axial skeleton plus cranial skeleton
@@ -246879,7 +246685,6 @@ synonym: "gustatory papillae" RELATED PLURAL []
synonym: "taste papilla" EXACT []
synonym: "taste papillae" RELATED PLURAL []
xref: FMA:54822
-is_a: CARO:0000006 ! material anatomical entity
is_a: UBERON:0001726 ! papilla of tongue
intersection_of: UBERON:0001726 ! papilla of tongue
intersection_of: has_part UBERON:0001727 ! taste bud
@@ -247599,7 +247404,6 @@ namespace: uberon
def: "An epithelium that is part of a frontonasal prominence." [OBOL:automatic]
xref: EHDAA2:0004108
xref: EMAPA:32918
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000490 {source="EHDAA2"} ! unilaminar epithelium
is_a: UBERON:0005291 ! embryonic tissue
intersection_of: UBERON:0000483 ! epithelium
@@ -247629,7 +247433,6 @@ def: "An anatomical space that is enclosed by a pleuroperitoneal canal." [OBOL:a
synonym: "pleuro-peritoneal canal cavity" EXACT [EMAPA:25034]
xref: EHDAA2:0004736
xref: EMAPA:25034
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000464 ! anatomical space
intersection_of: UBERON:0000464 ! anatomical space
intersection_of: luminal_space_of UBERON:0006279 ! pleuroperitoneal canal
@@ -247963,7 +247766,6 @@ def: "A portion of tissue that will develop into vasculature." [ZFA:0005076, ZFA
xref: EFO:0003708
xref: TAO:0005076
xref: ZFA:0005076
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0001048 ! primordium
intersection_of: UBERON:0001048 ! primordium
intersection_of: has_potential_to_develop_into UBERON:0002049 ! vasculature
@@ -248030,7 +247832,6 @@ synonym: "MZ" BROAD ABBREVIATION [BRAINSPAN:BRAINSPAN, MP:0000792]
xref: EMAPA:17546
xref: EMAPA:32713
xref: PBA:294021774
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0014950 ! layer of developing cerebral cortex
relationship: develops_from UBERON:0004062 ! neural tube marginal layer
relationship: part_of UBERON:0010403 ! brain marginal zone
@@ -250054,7 +249855,6 @@ id: UBERON:0016611
name: auditory hillocks, pharyngeal arch 1 derived
namespace: uberon
def: "A collection of protruberances derived from pharyngeal arch 1 that develop into the tragus, crus of the helix, and helix." [http://php.med.unsw.edu.au/embryology/index.php?title=Hearing_-_Outer_Ear_Development#Pinna-_Auricle]
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000477 ! anatomical cluster
intersection_of: UBERON:0000477 ! anatomical cluster
intersection_of: develops_from UBERON:0004362 ! pharyngeal arch 1
@@ -250067,7 +249867,6 @@ id: UBERON:0016612
name: auditory hillocks, pharyngeal arch 2 derived
namespace: uberon
def: "A collection of protruberances derived from pharyngeal arch 2 that develop into the concha, antihelix and antitragus." [http://php.med.unsw.edu.au/embryology/index.php?title=Hearing_-_Outer_Ear_Development#Pinna-_Auricle]
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000477 ! anatomical cluster
intersection_of: UBERON:0000477 ! anatomical cluster
intersection_of: develops_from UBERON:0003066 ! pharyngeal arch 2
@@ -250126,7 +249925,6 @@ def: "The joint that is formed by the union of the humerus, the scapula (or shou
synonym: "joint of shoulder region" EXACT []
xref: MESH:D012785
xref: SCTID:361835002
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000982 ! skeletal joint
intersection_of: UBERON:0000982 ! skeletal joint
intersection_of: part_of UBERON:0001467 ! shoulder
@@ -250213,7 +250011,6 @@ namespace: uberon
def: "A bony structure embedded in skin, roughly equivalent to osteoderms." [PHENOSCAPE:Nizar]
synonym: "bony tubercle" BROAD []
synonym: "bony tubercles" RELATED PLURAL [UBERONTEMP:3b77fb04-1e62-43af-a84b-5d5eb7388525]
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0005813 ! tubercle
is_a: UBERON:0013703 ! integumentary projection
intersection_of: UBERON:0005813 ! tubercle
@@ -250241,8 +250038,8 @@ namespace: uberon
def: "A set of teeth in which each tooth that attaches to a vomer." [OBOL:automatic]
synonym: "vomerine teeth" RELATED []
xref: AAO:0000635
-is_a: CARO:0000003 ! connected anatomical structure
is_a: UBERON:0003672 ! dentition
+is_a: UBERON:0010314 ! structure with developmental contribution from neural crest
intersection_of: UBERON:0003672 ! dentition
intersection_of: attaches_to UBERON:0002396 ! vomer
relationship: attaches_to UBERON:0002396 ! vomer
@@ -250566,7 +250363,7 @@ subset: pheno_slim
synonym: "pulmonary lymphatic chain" EXACT [FMA:67999]
synonym: "pulmonary lymphatic vasculature" RELATED []
xref: FMA:67999
-is_a: CARO:0000000 ! anatomical entity
+is_a: PR:000050567 ! protein-containing material entity
is_a: UBERON:0011216 ! organ system subdivision
intersection_of: UBERON:0011216 ! organ system subdivision
intersection_of: part_of UBERON:0002048 ! lung
@@ -250584,9 +250381,11 @@ subset: human_reference_atlas
synonym: "lymphatic vessel of lung" EXACT []
xref: FMA:234006
xref: SCTID:321862009
+is_a: PR:000050567 ! protein-containing material entity
is_a: UBERON:0003456 ! respiratory system lymphatic vessel
intersection_of: UBERON:0001473 ! lymphatic vessel
intersection_of: part_of UBERON:0002048 ! lung
+relationship: has_part UBERON:0003529 ! respiratory system lymphatic vessel endothelium
relationship: part_of UBERON:0018226 ! pulmonary part of lymphatic system
relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens
@@ -250719,7 +250518,6 @@ subset: grouping_class
xref: EHDAA2:0001842
xref: EMAPA:35578
xref: MA:0000165
-is_a: CARO:0000006 ! material anatomical entity
is_a: UBERON:0000061 ! anatomical structure
relationship: composed_primarily_of UBERON:0014892 ! skeletal muscle organ
relationship: part_of UBERON:0000383 {source="MA"} ! musculature of body
@@ -250776,7 +250574,6 @@ def: "Any organ component layer that consists of muscle tissue." [http://orcid.o
xref: FMA:45634
xref: NCIT:C75444
xref: UMLS:C0225358
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0004923 ! organ component layer
intersection_of: UBERON:0004923 ! organ component layer
intersection_of: composed_primarily_of UBERON:0002385 ! muscle tissue
@@ -251118,7 +250915,6 @@ synonym: "choroid and retina" EXACT []
synonym: "retinachoroid" EXACT []
synonym: "retinachoroidal region" EXACT []
xref: SCTID:110701000
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000481 ! multi-tissue structure
relationship: has_part UBERON:0000966 ! retina
relationship: has_part UBERON:0001776 ! optic choroid
@@ -251643,7 +251439,6 @@ namespace: uberon
def: "A specific region of the foregut into the area in which the lung will develop." [GOC:dph, GOC:mtg_lung]
synonym: "lung field" EXACT []
xref: SCTID:34922002
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0007688 ! anlage
intersection_of: UBERON:0007688 ! anlage
intersection_of: has_potential_to_develop_into UBERON:0002048 ! lung
@@ -251898,7 +251693,6 @@ namespace: uberon
def: "A cranial nerve fiber tract that innervates the parietal eye." [ISBN:0471888893]
comment: This should be classified as an evaginated sensory afferents rather than cranial nerves, as they are part of the CNS[ISBN:0471888893]
synonym: "epiphyseal nerve" RELATED [ISBN:0471888893]
-is_a: CARO:0001001 ! neuron projection bundle
is_a: UBERON:0011215 ! central nervous system cell part cluster
is_a: UBERON:0034713 ! cranial neuron projection bundle
intersection_of: UBERON:0034713 ! cranial neuron projection bundle
@@ -251914,7 +251708,6 @@ def: "A cranial nerve fiber tract that innervates the pineal body." [ISBN:047188
comment: This should be classified as an evaginated sensory afferents rather than cranial nerves, as they are part of the CNS[ISBN:0471888893]
synonym: "pineal nerve" RELATED [ISBN:0471888893]
xref: FMA:77600
-is_a: CARO:0001001 ! neuron projection bundle
is_a: UBERON:0011215 ! central nervous system cell part cluster
is_a: UBERON:0034713 ! cranial neuron projection bundle
intersection_of: UBERON:0034713 ! cranial neuron projection bundle
@@ -252131,7 +251924,6 @@ name: prechordal mesoderm
namespace: uberon
def: "The area of axial mesoderm that develops into the prechordal plate." [MGI:anna]
synonym: "prechordal mesenchyme" EXACT []
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0002050 ! embryonic structure
intersection_of: UBERON:0005423 ! developing anatomical structure
intersection_of: has_potential_to_develop_into UBERON:0003063 ! prechordal plate
@@ -252292,7 +252084,6 @@ id: UBERON:0034929
name: external soft tissue zone
namespace: uberon
def: "A region or zone on the surface of an organism that encompasses skin and any adnexa, down through muscles and bounded by underlying skeletal support structures." [http://orcid.org/0000-0002-6601-2165]
-is_a: CARO:0000006 ! material anatomical entity
is_a: PR:000050567 ! protein-containing material entity
is_a: UBERON:0010000 ! multicellular anatomical structure
relationship: has_part UBERON:0000014 ! zone of skin
@@ -252704,7 +252495,6 @@ xref: NCIT:C77674
xref: SCTID:181074000
xref: UMLS:C0446824
xref: Wikipedia:Plantar_nerve
-is_a: CARO:0001001 ! neuron projection bundle
is_a: UBERON:0003431 ! leg nerve
intersection_of: UBERON:0001021 ! nerve
intersection_of: innervates UBERON:0008338 ! plantar part of pes
@@ -253374,7 +253164,6 @@ namespace: uberon
def: "Any nerve that innervates the larynx." [UBERON:cjm]
xref: MESH:D007823
xref: SCTID:307013006
-is_a: CARO:0001001 ! neuron projection bundle
is_a: UBERON:0001021 ! nerve
intersection_of: UBERON:0001021 ! nerve
intersection_of: innervates UBERON:0001737 ! larynx
@@ -253388,7 +253177,6 @@ def: "Any nerve that innervates the pinna." [UBERON:cjm]
synonym: "auricular nerve" EXACT [MA:0001232]
xref: EMAPA:36513
xref: MA:0001232
-is_a: CARO:0001001 ! neuron projection bundle
is_a: UBERON:0001021 ! nerve
intersection_of: UBERON:0001021 ! nerve
intersection_of: innervates UBERON:0001757 ! pinna
@@ -253403,7 +253191,6 @@ def: "Any nerve that innervates the penis." [UBERON:cjm]
synonym: "penile nerve" EXACT []
synonym: "penis nerve" EXACT []
xref: EMAPA:35057
-is_a: CARO:0001001 ! neuron projection bundle
is_a: UBERON:0001021 ! nerve
intersection_of: UBERON:0001021 ! nerve
intersection_of: innervates UBERON:0000989 ! penis
@@ -253417,7 +253204,6 @@ def: "Any nerve that innervates the clitoris." [UBERON:cjm]
synonym: "clitoral nerve" EXACT []
synonym: "clitoris nerve" EXACT []
xref: EMAPA:35044
-is_a: CARO:0001001 ! neuron projection bundle
is_a: UBERON:0001021 ! nerve
intersection_of: UBERON:0001021 ! nerve
intersection_of: innervates UBERON:0002411 ! clitoris
@@ -253428,7 +253214,6 @@ id: UBERON:0035651
name: glans
namespace: uberon
xref: Wikipedia:Glans
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000063 ! organ subunit
is_a: UBERON:0005156 ! reproductive structure
union_of: UBERON:0001299 ! glans penis
@@ -253496,7 +253281,6 @@ def: "The primordial mouth region of the developing head." [MP:0003119]
synonym: "primitive mouth" EXACT [FMA:293105]
synonym: "primordial mouth" EXACT []
xref: FMA:293105
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0013522 ! subdivision of tube
relationship: has_part UBERON:0000925 ! endoderm
relationship: has_part UBERON:0000930 ! stomodeum
@@ -253713,7 +253497,6 @@ name: respiratory primordium mesenchyme
namespace: uberon
synonym: "respiratory primordium associated mesenchyme" EXACT [EHDAA2:0004071]
xref: EHDAA2:0004071
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0003104 ! mesenchyme
intersection_of: UBERON:0003104 ! mesenchyme
intersection_of: part_of UBERON:0008947 ! respiratory primordium
@@ -253738,7 +253521,6 @@ def: "An organ subunit in the skin that gives rise to cutaneous appendage." [htt
synonym: "cutaneous appendage follicle" EXACT []
synonym: "follicle" BROAD []
synonym: "skin follicle" EXACT []
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000063 ! organ subunit
intersection_of: UBERON:0000063 ! organ subunit
intersection_of: has_potential_to_develop_into UBERON:0000021 ! cutaneous appendage
@@ -254333,7 +254115,6 @@ namespace: uberon
def: "Wall of organ which has as its parts the endocardium, myocardium , epicardium, and the cardiac septum, surrounded by the pericardial sac proper and is continuous with the walls of the systemic and pulmonary arterial and venous trees." [FMA:7274]
synonym: "cardiac wall" EXACT [FMA:7274]
xref: FMA:7274
-is_a: CARO:0010000 ! multicellular anatomical structure
is_a: UBERON:0000060 {source="FMA"} ! anatomical wall
intersection_of: UBERON:0000060 ! anatomical wall
intersection_of: part_of UBERON:0000948 ! heart
@@ -255134,7 +254915,6 @@ synonym: "digit" BROAD [http://orcid.org/0000-0002-6601-2165]
synonym: "digit ( phalanges plus metapodial) plus soft tissue" BROAD COMPARATIVE_PREFERRED [http://orcid.org/0000-0002-6601-2165]
synonym: "digit digitopodial subdivision" EXACT [http://orcid.org/0000-0002-6601-2165]
synonym: "digit ray" EXACT [http://orcid.org/0000-0002-6601-2165]
-is_a: CARO:0010000 ! multicellular anatomical structure
is_a: UBERON:0000475 ! organism subdivision
intersection_of: UBERON:0000475 ! organism subdivision
intersection_of: has_skeleton UBERON:5102544 ! individual digit of digitopodial skeleton
@@ -255178,7 +254958,6 @@ namespace: uberon
def: "A subdivision of the skeleton of the autopod consisting of the phalanges of a single digit plus the associated metapodial element." [http://orcid.org/0000-0002-6601-2165]
synonym: "digit" RELATED COMPARATIVE_PREFERRED [http://orcid.org/0000-0002-6601-2165]
synonym: "digit skeleton" RELATED [http://orcid.org/0000-0002-6601-2165]
-is_a: CARO:0010000 ! multicellular anatomical structure
is_a: UBERON:0010712 ! limb skeleton subdivision
intersection_of: UBERON:0010912 ! subdivision of skeleton
intersection_of: skeleton_of UBERON:5002544 ! digit plus metapodial segment
@@ -255645,7 +255424,6 @@ name: ductal plate
namespace: uberon
def: "In human, ductal plate is a double-layered cylindrical structure of bile duct epithelium that surrounds the portal ramifications by the eighth gestational week. After approximately the 12th gestational week, remodelling of ductal plate begins, and maturity is attained by the end of gestation or early postnatal period." [http://orcid.org/0000-0002-7073-9172, PMID:28515578]
subset: added_for_HCA
-is_a: CARO:0000000 ! anatomical entity
is_a: PR:000050567 ! protein-containing material entity
is_a: UBERON:0010000 ! multicellular anatomical structure
relationship: dc-contributor https://orcid.org/0000-0002-2825-0621
@@ -256085,7 +255863,6 @@ name: anorectum
namespace: uberon
def: "A subdivision of the digestive tract in humans that includes the rectum, the anal canal and the anus." [DOI:10.1007/978-3-319-26938-2_8, DOI:10.1148/rg.2015150037, http://orcid.org/0000-0002-6826-8770, http://orcid.org/0000-0003-3440-1876, PMID:29742860]
synonym: "anorectal canal" NARROW []
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0004921 ! subdivision of digestive tract
intersection_of: UBERON:0004921 ! subdivision of digestive tract
intersection_of: has_part UBERON:0000159 ! anal canal
@@ -256347,7 +256124,6 @@ namespace: uberon
def: "The deepest layer of the neocortex. While layer 6b is considered part of layer 6, it is distinct morphologically, genetically, and developmentally from the rest of layer 6. Neurons in L6b project to cortical targets and higher-order thalamus and develop from a precursor population that arises from the subplate." [PMID:32160552]
synonym: "cerebral cortex layer 6b" EXACT []
synonym: "neocortex layer 6b" EXACT []
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0002301 ! layer of neocortex
relationship: develops_from UBERON:0004035 ! cortical subplate
relationship: part_of UBERON:0005395 ! cortical layer VI
@@ -256718,6 +256494,16 @@ id: CL:4030046
name: lacks_plasma_membrane_part
expand_expression_to: "http://purl.obolibrary.org/obo/BFO_0000051 exactly 0 (http://purl.obolibrary.org/obo/GO_0005886 and http://purl.obolibrary.org/obo/BFO_0000051 some ?Y)" []
+[Typedef]
+id: IAO:0000136
+name: is about
+def: "A (currently) primitive relation that relates an information artifact to an entity." []
+property_value: editor_note "7/6/2009 Alan Ruttenberg. Following discussion with Jonathan Rees, and introduction of \"mentions\" relation. Weaken the is_about relationship to be primitive. \n\nWe will try to build it back up by elaborating the various subproperties that are more precisely defined.\n\nSome currently missing phenomena that should be considered \"about\" are predications - \"The only person who knows the answer is sitting beside me\" , Allegory, Satire, and other literary forms that can be topical without explicitly mentioning the topic." xsd:string
+property_value: IAO:0000112 "This document is about information artifacts and their representations" xsd:string
+property_value: IAO:0000114 IAO:0000125
+property_value: IAO:0000117 "person:Alan Ruttenberg" xsd:string
+property_value: IAO:0000119 "Smith, Ceusters, Ruttenberg, 2000 years of philosophy" xsd:string
+
[Typedef]
id: RO:0000052
name: characteristic of
@@ -256879,7 +256665,7 @@ def: "A relationship that holds between a GO molecular function and a component
comment: By convention GO molecular functions are classified by their effector function and internal regulatory functions are treated as components. So, for example calmodulin has a protein binding activity that has positive regulatory component activity calcium binding activity. Receptor tyrosine kinase activity is a tyrosine kinase activity that has positive regulatory component 'ligand binding'.
is_a: has_regulatory_component_activity ! has regulatory component activity
is_a: positively_regulated_by ! positively regulated by
-created_by: dos
+created_by: https://orcid.org/0000-0002-7073-9172
creation_date: 2017-05-24T09:31:17Z
[Typedef]
@@ -256887,7 +256673,7 @@ id: RO:0002017
name: has component activity
comment: A 'has component activity' B if A is A and B are molecular functions (GO_0003674) and A has_component B.
is_a: RO:0002018 ! has component process
-created_by: dos
+created_by: https://orcid.org/0000-0002-7073-9172
creation_date: 2017-05-24T09:44:33Z
[Typedef]
@@ -256897,7 +256683,7 @@ def: "w 'has process component' p if p and w are processes, w 'has part' p and
domain: BFO:0000015 ! process
range: BFO:0000015 ! process
is_a: has_component ! has component
-created_by: dos
+created_by: https://orcid.org/0000-0002-7073-9172
creation_date: 2017-05-24T09:49:21Z
[Typedef]
@@ -256905,44 +256691,44 @@ id: RO:0002021
name: occurs across
def: "A relationship between a process and a barrier, where the process occurs in a region spanning the barrier. For cellular processes the barrier is typically a membrane. Examples include transport across a membrane and membrane depolarization." []
is_a: RO:0002479 ! has part that occurs in
-created_by: dos
+created_by: https://orcid.org/0000-0002-7073-9172
creation_date: 2017-07-20T17:19:37Z
[Typedef]
id: RO:0002022
name: directly regulated by
-comment: Process(P2) is directly regulated by process(P1) iff: P1 regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding regulates the kinase activity (P2) of protein B then P1 directly regulates P2. {xref="GOC:dos"}
+comment: Process(P2) is directly regulated by process(P1) iff: P1 regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding regulates the kinase activity (P2) of protein B then P1 directly regulates P2. {xref="https://orcid.org/0000-0002-7073-9172"}
is_a: regulated_by ! regulated by
inverse_of: directly_regulates ! directly regulates
-created_by: dos
+created_by: https://orcid.org/0000-0002-7073-9172
creation_date: 2017-09-17T13:52:24Z
[Typedef]
id: RO:0002023
name: directly negatively regulated by
-def: "Process(P2) is directly negatively regulated by process(P1) iff: P1 negatively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding negatively regulates the kinase activity (P2) of protein B then P2 directly negatively regulated by P1." [GOC:dos]
+def: "Process(P2) is directly negatively regulated by process(P1) iff: P1 negatively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding negatively regulates the kinase activity (P2) of protein B then P2 directly negatively regulated by P1." [https://orcid.org/0000-0002-7073-9172]
is_a: RO:0002022 ! directly regulated by
inverse_of: directly_negatively_regulates ! directly negatively regulates
-created_by: dos
+created_by: https://orcid.org/0000-0002-7073-9172
creation_date: 2017-09-17T13:52:38Z
[Typedef]
id: RO:0002024
name: directly positively regulated by
-def: "Process(P2) is directly postively regulated by process(P1) iff: P1 positively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding positively regulates the kinase activity (P2) of protein B then P2 is directly postively regulated by P1." [GOC:dos]
+def: "Process(P2) is directly postively regulated by process(P1) iff: P1 positively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding positively regulates the kinase activity (P2) of protein B then P2 is directly postively regulated by P1." [https://orcid.org/0000-0002-7073-9172]
is_a: RO:0002022 ! directly regulated by
inverse_of: directly_positively_regulates ! directly positively regulates
-created_by: dos
+created_by: https://orcid.org/0000-0002-7073-9172
creation_date: 2017-09-17T13:52:47Z
[Typedef]
id: RO:0002025
name: has effector activity
-def: "A 'has effector activity' B if A and B are GO molecular functions (GO_0003674), A 'has component activity' B and B is the effector (output function) of B. Each compound function has only one effector activity." [GOC:dos]
+def: "A 'has effector activity' B if A and B are GO molecular functions (GO_0003674), A 'has component activity' B and B is the effector (output function) of B. Each compound function has only one effector activity." [https://orcid.org/0000-0002-7073-9172]
comment: This relation is designed for constructing compound molecular functions, typically in combination with one or more regulatory component activity relations.
is_functional: true
is_a: RO:0002017 ! has component activity
-created_by: dos
+created_by: https://orcid.org/0000-0002-7073-9172
creation_date: 2017-09-22T14:14:36Z
[Typedef]
@@ -256967,14 +256753,14 @@ is_a: RO:0002222 ! temporally related to
id: RO:0002100
name: has soma location
namespace: fly_anatomy.ontology
-def: "Relation between a neuron and an anatomical structure that its soma is part of." []
+def: "Relation between a neuron and a material anatomical entity that its soma is part of." []
def: "Relation between a neuron and an anatomical structure that its soma is part of." [https://orcid.org/0000-0002-7073-9172]
xref: RO:0002100
property_value: IAO:0000114 IAO:0000125
property_value: IAO:0000117 https://orcid.org/0000-0002-7073-9172
property_value: RO:0001900 RO:0001901
domain: CL:0000540 ! neuron
-range: CARO:0000003 ! connected anatomical structure
+range: UBERON:0000465 ! material anatomical entity
is_a: overlaps ! overlaps
transitive_over: part_of ! part_of
expand_expression_to: "BFO_0000051 some (\n GO_0043025 and BFO_0000050 some ?Y)" []
@@ -256994,7 +256780,7 @@ property_value: IAO:0000118 "fasciculates with" xsd:string
property_value: IAO:0000426 "(forall (?x ?y) \n (iff \n (fasciculates_with ?x ?y)\n (exists (?nps ?npbs)\n (and \n (\"neuron ; CL_0000540\" ?x)\n (\"neuron projection bundle ; CARO_0001001\" ?y) \n (\"neuron projection segment ; CARO_0001502\" ?nps)\n (\"neuron projection bundle segment ; CARO_0001500' \" ?npbs)\n (part_of ?npbs ?y) \n (part_of ?nps ?x)\n (part_of ?nps ?npbs)\n (forall (?npbss)\n (if\n (and \n (\"neuron projection bundle subsegment ; CARO_0001501\" ?npbss)\n (part_of ?npbss ?npbs) \n )\n (overlaps ?nps ?npbss)\n ))))))" xsd:string
property_value: RO:0001900 RO:0001901
domain: CL:0000540 ! neuron
-range: CARO:0001001 ! neuron projection bundle
+range: UBERON:0000122 ! neuron projection bundle
is_a: overlaps ! overlaps
inverse_of: RO:0002132 ! has fasciculating neuron projection
@@ -257023,8 +256809,8 @@ property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000117 https://orcid.org/0000-0003-1617-8244
property_value: IAO:0000119 http://www.ncbi.nlm.nih.gov/pubmed/19243617
property_value: RO:0001900 RO:0001901
-domain: CARO:0000006 ! material anatomical entity
-range: CARO:0000006 ! material anatomical entity
+domain: UBERON:0000465 ! material anatomical entity
+range: UBERON:0000465 ! material anatomical entity
is_a: has_part ! has part
expand_expression_to: "BFO_0000051 some (GO_0005886 and BFO_0000051 some ?Y)" []
@@ -257110,7 +256896,7 @@ property_value: IAO:0000117 https://orcid.org/0000-0002-7073-9172
property_value: IAO:0000118 "has fasciculating component" xsd:string
property_value: IAO:0000426 "(forall (?x ?y) \n (iff \n (has_fasciculating_neuron_projection ?x ?y)\n (exists (?nps ?npbs) \n (and \n (\"neuron projection bundle ; CARO_0001001\" ?x)\n (\"neuron projection ; GO0043005\" ?y)\n (\"neuron projection segment ; CARO_0001502\" ?nps)\n (\"neuron projection bundle segment ; CARO_0001500\" ?npbs)\n (part_of ?nps ?y)\n (part_of ?npbs ?x)\n (part_of ?nps ?npbs)\n (forall (?npbss)\n (if\n (and \n (\"neuron projection bundle subsegment ; CARO_0001501\" ?npbss)\n (part_of ?npbss ?npbs) \n )\n (overlaps ?nps ?npbss)\n ))))))\n\n\n" xsd:string
property_value: RO:0001900 RO:0001901
-domain: CARO:0001001 ! neuron projection bundle
+domain: UBERON:0000122 ! neuron projection bundle
is_a: overlaps ! overlaps
[Typedef]
@@ -257150,7 +256936,7 @@ property_value: IAO:0000112 "'neural crest cell' SubClassOf expresses some 'Wnt
property_value: IAO:0000114 IAO:0000125
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
domain: BFO:0000002 ! continuant
-range: CARO:0000006 ! material anatomical entity
+range: UBERON:0000465 ! material anatomical entity
is_a: RO:0002330 ! genomically related to
inverse_of: RO:0002292 ! expresses
transitive_over: part_of ! part_of
@@ -257228,7 +257014,7 @@ def: "c acts upstream of or within p if c is enables f, and f is causally upstre
subset: http://purl.obolibrary.org/obo/valid_for_go_gp2term
synonym: "affects" RELATED []
property_value: IAO:0000112 "A gene product that has some activity, where that activity may be a part of a pathway or upstream of the pathway." xsd:string
-property_value: seeAlso http://wiki.geneontology.org/index.php/Acts_upstream_of_or_within
+property_value: seeAlso "https://wiki.geneontology.org/Acts_upstream_of_or_within" xsd:anyURI
holds_over_chain: RO:0002327 causally_upstream_of_or_within
is_a: RO:0002500 ! causal agent in process
@@ -257252,7 +257038,7 @@ is_a: RO:0002286 ! developmentally succeeded by
[Typedef]
id: RO:0002292
name: expresses
-def: "Inverse of 'expressed in'" []
+def: "y expresses x if and only if there is a gene expression process (GO:0010467) that occurs in y, and one of the following holds: (i) x is a gene, and x is transcribed into a transcript as part of the gene expression process (ii) x is a transcript, and x was transcribed from a gene as part of the gene expression process (iii) x is a mature gene product (protein or RNA), and x was translated or otherwise processed from a transcript that was transcribed as part of the gene expression process." []
property_value: IAO:0000114 IAO:0000125
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
is_a: RO:0002330 ! genomically related to
@@ -257306,6 +257092,7 @@ property_value: IAO:0000118 "has" xsd:string
property_value: IAO:0000118 "is catalyzing" xsd:string
property_value: IAO:0000118 "is executing" xsd:string
property_value: IAO:0000232 "This relation differs from the parent relation 'capable of' in that the parent is weaker and only expresses a capability that may not be actually realized, whereas this relation is always realized." xsd:string
+property_value: seeAlso "https://wiki.geneontology.org/Enables" xsd:anyURI
is_a: capable_of ! capable of
inverse_of: RO:0002333 ! enabled by
transitive_over: has_part ! has part
@@ -257336,7 +257123,7 @@ def: "c involved_in p if and only if c enables some process p', and p' is part o
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000118 "actively involved in" xsd:string
property_value: IAO:0000118 "enables part of" xsd:string
-property_value: seeAlso Involved:in
+property_value: seeAlso "https://wiki.geneontology.org/Involved_in" xsd:anyURI
holds_over_chain: RO:0002327 part_of
is_a: participates_in ! participates in
is_a: RO:0002431 ! involved in or involved in regulation of
@@ -257348,6 +257135,7 @@ name: enabled by
def: "inverse of enables" []
subset: http://purl.obolibrary.org/obo/valid_for_gocam
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
+property_value: seeAlso "https://wiki.geneontology.org/Enabled_by" xsd:anyURI
is_a: functionally_related_to ! functionally related to
is_a: has_participant ! has participant
@@ -257415,8 +257203,8 @@ name: has developmental potential involving
def: "x has developmental potential involving y iff x is capable of a developmental process with output y. y may be the successor of x, or may be a different structure in the vicinity (as for example in the case of developmental induction)." []
property_value: IAO:0000114 IAO:0000428
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
-domain: CARO:0000000 ! anatomical entity
-range: CARO:0000000 ! anatomical entity
+domain: UBERON:0001062 ! anatomical entity
+range: UBERON:0001062 ! anatomical entity
is_a: RO:0002324 ! developmentally related to
[Typedef]
@@ -257442,6 +257230,7 @@ def: "p indirectly positively regulates q iff p is indirectly causally upstream
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000118 "indirectly activates" xsd:string
property_value: RO:0002579 RO:0002213
+property_value: seeAlso "https://wiki.geneontology.org/Indirectly_positively_regulates" xsd:anyURI
holds_over_chain: directly_positively_regulates directly_positively_regulates
holds_over_chain: directly_positively_regulates RO:0002407
holds_over_chain: RO:0002409 RO:0002409
@@ -257457,6 +257246,7 @@ def: "p indirectly negatively regulates q iff p is indirectly causally upstream
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000118 "indirectly inhibits" xsd:string
property_value: RO:0002579 RO:0002212
+property_value: seeAlso "https://wiki.geneontology.org/Indirectly_negatively_regulates" xsd:anyURI
holds_over_chain: directly_negatively_regulates directly_negatively_regulates
holds_over_chain: directly_negatively_regulates RO:0002409
is_transitive: true
@@ -257516,11 +257306,12 @@ is_a: RO:0002500 ! causal agent in process
[Typedef]
id: RO:0002432
name: is active in
-def: "c executes activity in d if and only if c enables p and p occurs_in d. Assuming no action at a distance by gene products, if a gene product enables (is capable of) a process that occurs in some structure, it must have at least some part in that structure." [GOC:cjm, GOC:dos]
+def: "c executes activity in d if and only if c enables p and p occurs_in d. Assuming no action at a distance by gene products, if a gene product enables (is capable of) a process that occurs in some structure, it must have at least some part in that structure." [https://orcid.org/0000-0002-6601-2165, https://orcid.org/0000-0002-7073-9172]
synonym: "enables activity in" EXACT []
property_value: IAO:0000112 "A protein that enables activity in a cytosol." xsd:string
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000118 "executes activity in" xsd:string
+property_value: seeAlso "https://wiki.geneontology.org/Is_active_in" xsd:anyURI
holds_over_chain: RO:0002327 occurs_in {http://purl.obolibrary.org/obo/RO_0002581="true"}
is_a: functionally_related_to ! functionally related to
is_a: overlaps ! overlaps
@@ -257727,8 +257518,8 @@ name: biomechanically related to
def: "A relation that holds between elements of a musculoskeletal system or its analogs." []
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000232 "Do not use this relation directly. It is ended as a grouping for a diverse set of relations, all involving the biomechanical processes." xsd:string
-domain: CARO:0000003 ! connected anatomical structure
-range: CARO:0000003 ! connected anatomical structure
+domain: UBERON:0000061 ! anatomical structure
+range: UBERON:0000061 ! anatomical structure
is_a: functionally_related_to ! functionally related to
[Typedef]
@@ -257784,6 +257575,12 @@ property_value: IAO:0000119 http://purl.obolibrary.org/obo/ro/docs/causal-relati
holds_over_chain: capable_of positively_regulates
is_a: RO:0002596 ! capable of regulating
+[Typedef]
+id: RO:0002610
+name: correlated with
+def: "A relationship that holds between two entities, where the entities exhibit a statistical dependence relationship. The entities may be statistical variables, or they may be other kinds of entities such as diseases, chemical entities or processes." []
+property_value: IAO:0000232 "Groups both positive and negative correlation" xsd:string
+
[Typedef]
id: RO:0004031
name: enables subfunction
@@ -257798,7 +257595,7 @@ id: RO:0004032
name: acts upstream of or within, positive effect
subset: http://purl.obolibrary.org/obo/valid_for_go_gp2term
property_value: RO:0004049 RO:0002264
-property_value: seeAlso http://wiki.geneontology.org/index.php/Acts_upstream_of_or_within,_positive_effect
+property_value: seeAlso "https://wiki.geneontology.org/Acts_upstream_of_or_within,_positive_effect" xsd:anyURI
holds_over_chain: RO:0002327 RO:0004047
is_a: RO:0002264 ! acts upstream of or within
created_by: https://orcid.org/0000-0002-6601-2165
@@ -257809,6 +257606,7 @@ id: RO:0004033
name: acts upstream of or within, negative effect
subset: http://purl.obolibrary.org/obo/valid_for_go_gp2term
property_value: RO:0004050 RO:0002264
+property_value: seeAlso "https://wiki.geneontology.org/Acts_upstream_of_or_within,_negative_effect" xsd:anyURI
holds_over_chain: RO:0002327 RO:0004046
is_a: RO:0002264 ! acts upstream of or within
created_by: https://orcid.org/0000-0002-6601-2165
@@ -257820,7 +257618,7 @@ name: acts upstream of, positive effect
def: "c 'acts upstream of, positive effect' p if c is enables f, and f is causally upstream of p, and the direction of f is positive" []
subset: http://purl.obolibrary.org/obo/valid_for_go_gp2term
property_value: RO:0004049 RO:0002263
-property_value: seeAlso http://wiki.geneontology.org/index.php/Acts_upstream_of,_positive_effect
+property_value: seeAlso "https://wiki.geneontology.org/Acts_upstream_of,_positive_effect" xsd:anyURI
holds_over_chain: RO:0002327 causally_upstream_of,_positive_effect
is_a: RO:0002263 ! acts upstream of
is_a: RO:0004032 ! acts upstream of or within, positive effect
@@ -257833,7 +257631,7 @@ name: acts upstream of, negative effect
def: "c 'acts upstream of, negative effect' p if c is enables f, and f is causally upstream of p, and the direction of f is negative" []
subset: http://purl.obolibrary.org/obo/valid_for_go_gp2term
property_value: RO:0004050 RO:0002263
-property_value: seeAlso http://wiki.geneontology.org/index.php/Acts_upstream_of,_negative_effect
+property_value: seeAlso "https://wiki.geneontology.org/Acts_upstream_of,_negative_effect" xsd:anyURI
holds_over_chain: RO:0002327 causally_upstream_of,_negative_effect
is_a: RO:0002263 ! acts upstream of
is_a: RO:0004033 ! acts upstream of or within, negative effect
@@ -257844,6 +257642,7 @@ creation_date: 2018-01-26T23:53:22Z
id: RO:0004046
name: causally upstream of or within, negative effect
property_value: RO:0004050 RO:0002418
+property_value: seeAlso "https://wiki.geneontology.org/Causally_upstream_of_or_within,_negative_effect" xsd:anyURI
is_a: causally_upstream_of_or_within ! causally upstream of or within
created_by: https://orcid.org/0000-0002-6601-2165
creation_date: 2018-03-13T23:55:05Z
@@ -257852,6 +257651,7 @@ creation_date: 2018-03-13T23:55:05Z
id: RO:0004047
name: causally upstream of or within, positive effect
property_value: RO:0004049 RO:0002418
+property_value: seeAlso https://wiki.geneontology.org/Causally_upstream_of_or_within,_positive_effect
is_a: causally_upstream_of_or_within ! causally upstream of or within
created_by: https://orcid.org/0000-0002-6601-2165
creation_date: 2018-03-13T23:55:19Z
@@ -257870,7 +257670,7 @@ id: RO:0012011
name: indirectly causally upstream of
def: "p is indirectly causally upstream of q iff p is causally upstream of q and there exists some process r such that p is causally upstream of r and r is causally upstream of q." []
is_a: causally_upstream_of ! causally upstream of
-created_by: pg
+created_by: https://orcid.org/0000-0003-1813-6857
creation_date: 2022-09-26T06:07:17Z
[Typedef]
@@ -257879,7 +257679,7 @@ name: indirectly regulates
def: "p indirectly regulates q iff p is indirectly causally upstream of q and p regulates q." []
is_a: regulates ! regulates
is_a: RO:0012011 ! indirectly causally upstream of
-created_by: pg
+created_by: https://orcid.org/0000-0003-1813-6857
creation_date: 2022-09-26T06:08:01Z
[Typedef]
@@ -257889,7 +257689,7 @@ def: "A relationship between a neuron and a region, where the neuron has a funct
synonym: "has synaptic input or output in" EXACT []
is_a: RO:0002130 ! has synaptic terminal in
transitive_over: part_of ! part_of
-created_by: http://orcid.org/0000-0002-1373-1705
+created_by: https://orcid.org/0000-0002-1373-1705
creation_date: 2020-07-17T09:26:52Z
[Typedef]
@@ -257902,7 +257702,7 @@ synonym: "has sensory terminal location" EXACT []
domain: CL:0000101 ! sensory neuron
is_a: RO:0002360 ! has dendrite location
transitive_over: part_of ! part_of
-created_by: http://orcid.org/0000-0002-1373-1705
+created_by: https://orcid.org/0000-0002-1373-1705
creation_date: 2020-07-20T12:10:09Z
[Typedef]
@@ -257944,8 +257744,8 @@ comment: Example: a spherical object has the quality of being spherical, and the
id: RO:0015015
name: has high plasma membrane amount
def: "A relation between a cell and molecule or complex such that every instance of the cell has a high number of instances of that molecule expressed on the cell surface." [PMID:19243617]
-property_value: dc-contributor http://orcid.org/0000-0003-1617-8244
-property_value: dc-contributor http://orcid.org/0000-0003-1940-6740
+property_value: dc-contributor https://orcid.org/0000-0003-1617-8244
+property_value: dc-contributor https://orcid.org/0000-0003-1940-6740
property_value: IAO:0000112 "'Ly-76 high positive erythrocyte' equivalent to 'enucleate erythrocyte' and (has_high_plasma_membrane_amount some 'lymphocyte antigen 76 (mouse)')" xsd:string
domain: CL:0000000 ! cell
is_a: RO:0002104 ! has plasma membrane part
@@ -257954,8 +257754,8 @@ is_a: RO:0002104 ! has plasma membrane part
id: RO:0015016
name: has low plasma membrane amount
def: "A relation between a cell and molecule or complex such that every instance of the cell has a low number of instances of that molecule expressed on the cell surface." [PMID:19243617]
-property_value: dc-contributor http://orcid.org/0000-0003-1617-8244
-property_value: dc-contributor http://orcid.org/0000-0003-1940-6740
+property_value: dc-contributor https://orcid.org/0000-0003-1617-8244
+property_value: dc-contributor https://orcid.org/0000-0003-1940-6740
property_value: IAO:0000112 "'DN2b thymocyte' equivalent to 'DN2 thymocyte' and (has_low_plasma_membrane_amount some 'mast/stem cell growth factor receptor')" xsd:string
domain: CL:0000000 ! cell
is_a: RO:0002104 ! has plasma membrane part
@@ -257973,6 +257773,16 @@ property_value: IAO:0000232 "See github ticket https://github.com/oborel/obo-rel
holds_over_chain: capable_of has_input
creation_date: 2021-11-08T12:00:00Z
+[Typedef]
+id: RO:0017003
+name: positively correlated with
+def: "A relation between entities in which one increases or decreases as the other does the same." []
+property_value: dc-contributor https://orcid.org/0000-0003-1909-9269
+property_value: IAO:0000118 "directly correlated with" xsd:string
+is_reflexive: true
+is_symmetric: true
+is_a: RO:0002610 ! correlated with
+
[Typedef]
id: acts_on_population_of
name: acts on population of
@@ -257983,7 +257793,7 @@ subset: http://purl.obolibrary.org/obo/valid_for_go_ontology
subset: http://purl.obolibrary.org/obo/valid_for_gocam
xref: RO:0012003
is_a: has_participant ! has participant
-created_by: pg
+created_by: https://orcid.org/0000-0003-1813-6857
creation_date: 2020-06-08T17:21:33Z
[Typedef]
@@ -258043,8 +257853,8 @@ namespace: uberon
def: "a is attached to part of b if a is attached to b, or a is attached to some p, where p is part of b." []
xref: RO:0002177
property_value: IAO:0000589 "attached to part of (anatomical structure to anatomical structure)" xsd:string
-domain: CARO:0000003 ! connected anatomical structure
-range: CARO:0000003 ! connected anatomical structure
+domain: UBERON:0000061 ! anatomical structure
+range: UBERON:0000061 ! anatomical structure
holds_over_chain: attaches_to part_of {http://purl.obolibrary.org/obo/RO_0002582="true"}
is_a: RO:0002323 ! mereotopologically related to
is_a: RO:0002567 ! biomechanically related to
@@ -258174,6 +257984,7 @@ subset: http://purl.obolibrary.org/obo/valid_for_gocam
xref: RO:0002305
property_value: http://purl.org/dc/terms/creator https://orcid.org/0000-0002-6601-2165
property_value: RO:0004050 RO:0002411
+property_value: seeAlso https://wiki.geneontology.org/Causally_upstream_of,_negative_effect
is_a: causally_upstream_of ! causally upstream of
is_a: RO:0004046 ! causally upstream of or within, negative effect
@@ -258188,6 +257999,7 @@ subset: http://purl.obolibrary.org/obo/valid_for_gocam
xref: RO:0002304
property_value: http://purl.org/dc/terms/creator https://orcid.org/0000-0002-6601-2165
property_value: RO:0004049 RO:0002411
+property_value: seeAlso https://wiki.geneontology.org/Causally_upstream_of,_positive_effect
is_a: causally_upstream_of ! causally upstream of
is_a: RO:0004047 ! causally upstream of or within, positive effect
@@ -258395,8 +258207,8 @@ property_value: IAO:0000119 " Developmental Biology, Gilbert, 8th edition, figur
property_value: IAO:0000119 "GO:0001759" xsd:string
property_value: IAO:0000119 http://www.ncbi.nlm.nih.gov/pubmed/20064205
property_value: IAO:0000232 "We place this under 'developmentally preceded by'. This placement should be examined in the context of reciprocal inductions[cjm]" xsd:string
-domain: CARO:0000006 ! material anatomical entity
-range: CARO:0000006 ! material anatomical entity
+domain: UBERON:0000465 ! material anatomical entity
+range: UBERON:0000465 ! material anatomical entity
is_a: RO:0002258 ! developmentally preceded by
inverse_of: RO:0002257 ! developmentally induces
@@ -258452,7 +258264,7 @@ property_value: IAO:0000114 IAO:0000125
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000119 "EHDAA2" xsd:string
property_value: IAO:0000119 "Jonathan Bard, EHDAA2" xsd:string
-domain: CARO:0000000 ! anatomical entity
+domain: UBERON:0001062 ! anatomical entity
holds_over_chain: directly_develops_from located_in
is_a: RO:0002258 ! developmentally preceded by
@@ -258484,6 +258296,7 @@ xref: RO:0002630
property_value: IAO:0000119 http://purl.obolibrary.org/obo/ro/docs/causal-relations
property_value: IAO:0000589 "directly negatively regulates (process to process)" xsd:string
property_value: RO:0004050 RO:0002578
+property_value: seeAlso "https://wiki.geneontology.org/Directly_negatively_regulates" xsd:anyURI
is_a: directly_regulates ! directly regulates
is_a: negatively_regulates ! negatively regulates
@@ -258499,6 +258312,7 @@ xref: RO:0002629
property_value: IAO:0000119 http://purl.obolibrary.org/obo/ro/docs/causal-relations
property_value: IAO:0000589 "directly positively regulates (process to process)" xsd:string
property_value: RO:0004049 RO:0002578
+property_value: seeAlso "https://wiki.geneontology.org/Directly_positively_regulates" xsd:anyURI
is_a: directly_regulates ! directly regulates
is_a: positively_regulates ! positively regulates
@@ -258561,7 +258375,13 @@ is_a: connected_to ! connected to
id: editor_note
name: editor note
namespace: uberon
+def: "An administrative note intended for its editor. It may not be included in the publication version of the ontology, so it should contain nothing necessary for end users to understand the ontology." []
xref: IAO:0000116
+property_value: IAO:0000111 "editor note" xsd:string
+property_value: IAO:0000114 IAO:0000122
+property_value: IAO:0000117 "PERSON:Daniel Schober" xsd:string
+property_value: IAO:0000119 "GROUP:OBI:" xsd:string
+property_value: isDefinedBy http://purl.obolibrary.org/obo/iao.owl
is_metadata_tag: true
[Typedef]
@@ -258762,8 +258582,8 @@ xref: RO:0002254
property_value: IAO:0000112 "Mammalian thymus has developmental contribution from some pharyngeal pouch 3; Mammalian thymus has developmental contribution from some pharyngeal pouch 4 [Kardong]" xsd:string
property_value: IAO:0000114 IAO:0000125
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
-domain: CARO:0000000 ! anatomical entity
-range: CARO:0000000 ! anatomical entity
+domain: UBERON:0001062 ! anatomical entity
+range: UBERON:0001062 ! anatomical entity
holds_over_chain: has_part develops_from
is_a: RO:0002258 ! developmentally preceded by
inverse_of: RO:0002255 ! developmentally contributes to
@@ -258804,6 +258624,7 @@ xref: RO:0002233
property_value: IAO:0000114 IAO:0000125
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000118 "consumes" xsd:string
+property_value: seeAlso "https://wiki.geneontology.org/Has_input" xsd:anyURI
domain: BFO:0000015 ! process
holds_over_chain: starts_with has_input
is_a: has_participant ! has participant
@@ -258846,7 +258667,7 @@ xref: RO:0002373
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000119 "Wikipedia:Insertion_(anatomy)" xsd:string
property_value: seeAlso http://dbpedia.org/property/insertion
-domain: CARO:0000003 {http://purl.obolibrary.org/obo/IAO_0000116="We need to import uberon muscle into RO to use as a stricter domain constraint"} ! connected anatomical structure
+domain: UBERON:0000061 {http://purl.obolibrary.org/obo/IAO_0000116="We need to import uberon muscle into RO to use as a stricter domain constraint"} ! anatomical structure
is_a: attaches_to ! attached to
is_a: RO:0002567 ! biomechanically related to
@@ -258859,7 +258680,7 @@ xref: RO:0002372
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000119 "Wikipedia:Insertion_(anatomy)" xsd:string
property_value: seeAlso http://dbpedia.org/property/origin
-domain: CARO:0000003 {comment="We need to import uberon muscle to create a stricter domain constraint"} ! connected anatomical structure
+domain: UBERON:0000061 {comment="We need to import uberon muscle to create a stricter domain constraint"} ! anatomical structure
is_a: attaches_to ! attached to
is_a: RO:0002567 ! biomechanically related to
@@ -258872,7 +258693,7 @@ comment: By convention GO molecular functions are classified by their effector f
xref: RO:0002014
is_a: has_regulatory_component_activity ! has regulatory component activity
is_a: negatively_regulated_by ! negatively regulated by
-created_by: dos
+created_by: https://orcid.org/0000-0002-7073-9172
creation_date: 2017-05-24T09:31:01Z
[Typedef]
@@ -258880,7 +258701,10 @@ id: has_ontology_root_term
name: has ontology root term
name: preferred_root
namespace: uberon
+def: "Ontology annotation property. Relates an ontology to a term that is a designated root term of the ontology. Display tools like OLS can use terms annotated with this property as the starting point for rendering the ontology class hierarchy. There can be more than one root." []
xref: IAO:0000700
+property_value: IAO:0000111 "has ontology root term" xsd:string
+property_value: IAO:0000117 "Nicolas Matentzoglu" xsd:string
is_metadata_tag: true
[Typedef]
@@ -258896,6 +258720,7 @@ xref: RO:0002234
property_value: IAO:0000114 IAO:0000125
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000118 "produces" xsd:string
+property_value: seeAlso "https://wiki.geneontology.org/Has_output" xsd:anyURI
holds_over_chain: ends_with has_output
is_a: has_participant ! has participant
inverse_of: output_of ! output of
@@ -258965,7 +258790,7 @@ is_a: RO:0002384 ! has developmental potential involving
id: has_primary_input
name: has primary input
namespace: external
-def: "p has primary input c if (a) p has input c and (b) the goal of process is to modify, consume, or transform c." [GOC:cjm, GOC:dph, GOC:kva, GOC:pt] {comment="PMID:27812932"}
+def: "p has primary input c if (a) p has input c and (b) the goal of process is to modify, consume, or transform c." [GOC:dph, GOC:kva, GOC:pt, https://orcid.org/0000-0002-6601-2165] {comment="PMID:27812932"}
subset: http://purl.obolibrary.org/obo/valid_for_go_ontology
xref: RO:0004009
is_a: has_input ! has input
@@ -258988,7 +258813,7 @@ creation_date: 2018-12-13T11:26:17Z
id: has_primary_output
name: has primary output
namespace: external
-def: "p has primary output c if (a) p has output c and (b) the goal of process is to modify, produce, or transform c." [GOC:cjm, GOC:dph, GOC:kva, GOC:pt] {comment="PMID:27812932"}
+def: "p has primary output c if (a) p has output c and (b) the goal of process is to modify, produce, or transform c." [GOC:dph, GOC:kva, GOC:pt, https://orcid.org/0000-0002-6601-2165] {comment="PMID:27812932"}
subset: http://purl.obolibrary.org/obo/valid_for_go_ontology
xref: RO:0004008
is_a: has_output ! has output
@@ -259016,7 +258841,7 @@ def: "A 'has regulatory component activity' B if A and B are GO molecular functi
xref: RO:0002013
is_a: regulated_by ! regulated by
is_a: RO:0002017 ! has component activity
-created_by: dos
+created_by: https://orcid.org/0000-0002-7073-9172
creation_date: 2017-05-24T09:30:46Z
[Typedef]
@@ -259029,9 +258854,9 @@ property_value: IAO:0000112 "Forelimb SubClassOf has_skeleton some 'Forelimb ske
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000118 "has supporting framework" xsd:string
property_value: IAO:0000232 "The skeleton of a structure may be a true skeleton (for example, the bony skeleton of a hand) or any kind of support framework (the hydrostatic skeleton of a sea star, the exoskeleton of an insect, the cytoskeleton of a cell)." xsd:string
-domain: CARO:0000003 ! connected anatomical structure
+domain: UBERON:0000061 ! anatomical structure
domain: UBERON:0000475 ! organism subdivision
-range: CARO:0000006 {http://purl.obolibrary.org/obo/IAO_0000116="This should be to a more restricted class, but not the Uberon class may be too restricted since it is a composition-based definition of skeleton rather than functional."} ! material anatomical entity
+range: UBERON:0000465 {http://purl.obolibrary.org/obo/IAO_0000116="This should be to a more restricted class, but not the Uberon class may be too restricted since it is a composition-based definition of skeleton rather than functional."} ! material anatomical entity
range: UBERON:0010912 ! subdivision of skeleton
is_a: has_part ! has part
inverse_of: skeleton_of ! skeleton of
@@ -259232,7 +259057,6 @@ property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000119 http://www.ncbi.nlm.nih.gov/pubmed/17921072
property_value: IAO:0000119 http://www.ncbi.nlm.nih.gov/pubmed/20973947
property_value: seeAlso https://github.com/obophenotype/uberon/wiki/Taxon-constraints
-range: CARO:0001010 ! organism
holds_over_chain: attaches_to in_taxon
holds_over_chain: capable_of in_taxon
holds_over_chain: connected_to in_taxon
@@ -259274,8 +259098,8 @@ namespace: uberon
xref: RO:0002005
property_value: http://purl.org/spar/cito/citesAsAuthority "http://www.ncbi.nlm.nih.gov/pubmed/22402613" xsd:anyURI
property_value: IAO:0000117 https://orcid.org/0000-0002-7073-9172
-domain: CARO:0000003 ! connected anatomical structure
-range: CARO:0001001 ! neuron projection bundle
+domain: UBERON:0000061 ! anatomical structure
+range: UBERON:0000122 ! neuron projection bundle
inverse_of: innervates ! innervates
transitive_over: branching_part_of ! branching part of
@@ -259291,7 +259115,7 @@ property_value: http://purl.org/spar/cito/citesAsAuthority http://www.ncbi.nlm.n
property_value: IAO:0000114 IAO:0000125
property_value: IAO:0000117 https://orcid.org/0000-0002-7073-9172
property_value: RO:0001900 RO:0001901
-domain: CARO:0001001 ! neuron projection bundle
+domain: UBERON:0000122 ! neuron projection bundle
transitive_over: part_of ! part_of
expand_expression_to: "RO_0002132 some (GO_0043005 that (RO_0002131 some (GO_0045202 that BFO_0000050 some ?Y)))" []
expand_expression_to: "RO_0002132 some (GO_0043005 that (RO_0002131 some (GO_0045202 that BFO_0000050 some Y?)))" []
@@ -259335,6 +259159,7 @@ property_value: IAO:0000112 "my brain is located in my head" xsd:string
property_value: IAO:0000112 "this rat is located in this cage" xsd:string
property_value: IAO:0000118 "located_in" xsd:string
property_value: RO:0001900 RO:0001901
+property_value: seeAlso "https://wiki.geneontology.org/Located_in" xsd:anyURI
domain: BFO:0000004 {http://purl.obolibrary.org/obo/IAO_0000116="This is redundant with the more specific 'independent and not spatial region' constraint. We leave in the redundant axiom for use with reasoners that do not use negation."} ! independent continuant
range: BFO:0000004 {http://purl.obolibrary.org/obo/IAO_0000116="This is redundant with the more specific 'independent and not spatial region' constraint. We leave in the redundant axiom for use with reasoners that do not use negation."} ! independent continuant
is_transitive: true
@@ -259363,7 +259188,7 @@ def: "x lumen_of y iff x is the space or substance that is part of y and does no
subset: ro-eco
xref: RO:0002571
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
-property_value: IAO:0000119 "GOC:cjm" xsd:string
+property_value: IAO:0000119 https://orcid.org/0000-0002-6601-2165
range: BFO:0000040 ! material entity
is_a: part_of ! part_of
@@ -259453,6 +259278,7 @@ property_value: IAO:0000118 "occurs_in" xsd:string
property_value: IAO:0000118 "unfolds in" xsd:string
property_value: IAO:0000118 "unfolds_in" xsd:string
property_value: isDefinedBy http://purl.obolibrary.org/obo/bfo.owl
+property_value: seeAlso "https://wiki.geneontology.org/Occurs_in" xsd:anyURI
domain: BFO:0000003 ! occurrent
range: BFO:0000004 ! independent continuant
holds_over_chain: part_of occurs_in
@@ -259539,6 +259365,7 @@ property_value: RO:0040042 BFO:0000031
property_value: seeAlso http://ontologydesignpatterns.org/wiki/Community:Parts_and_Collections
property_value: seeAlso http://ontologydesignpatterns.org/wiki/Submissions:PartOf
property_value: seeAlso "http://www.obofoundry.org/ro/#OBO_REL:part_of" xsd:string
+property_value: seeAlso "https://wiki.geneontology.org/Part_of" xsd:anyURI
is_transitive: true
is_a: overlaps ! overlaps
inverse_of: has_part ! has part
@@ -259820,7 +259647,7 @@ xref: RO:0002315
property_value: IAO:0000112 "an annotation of gene X to cell differentiation with results_in_maturation_of CL:0000057 (fibroblast) means that at the end of the process the input cell that did not have features of a fibroblast, now has the features of a fibroblast." xsd:string
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000119 "GOC:mtg_berkeley_2013" xsd:string
-range: CARO:0000003 ! connected anatomical structure
+range: UBERON:0000061 ! anatomical structure
is_a: results_in_changes_to_anatomical_or_cellular_structure ! results in changes to anatomical or cellular structure
is_a: results_in_developmental_progression_of ! results in developmental progression of
@@ -259872,7 +259699,7 @@ property_value: IAO:0000114 IAO:0000125
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: seeAlso Ontology:extensions
domain: GO:0008150 ! biological_process
-range: CARO:0000000 ! anatomical entity
+range: UBERON:0001062 ! anatomical entity
is_a: RO:0002324 ! developmentally related to
[Typedef]
@@ -259924,7 +259751,7 @@ subset: http://purl.obolibrary.org/obo/valid_for_go_ontology
subset: http://purl.obolibrary.org/obo/valid_for_gocam
xref: RO:0012008
is_a: results_in_organization_of ! results in organization of
-created_by: pg
+created_by: https://orcid.org/0000-0003-1813-6857
creation_date: 2021-02-26T07:28:29Z
[Typedef]
@@ -260039,11 +259866,13 @@ is_a: homologous_to ! shares ancestor with
id: simultaneous_with
name: simultaneous with
namespace: uberon
+def: "x simultaneous with y iff ω(x) = ω(y) and ω(α ) = ω(α), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point and '=' indicates the same instance in time." []
comment: t1 simultaneous_with t2 iff:= t1 before_or_simultaneous_with t2 and not (t1 before t2)
subset: ro-eco
xref: RO:0002082
property_value: IAO:0000117 "David Osumi-Sutherland" xsd:string
property_value: IAO:0000117 https://orcid.org/0000-0002-7073-9172
+is_symmetric: true
is_transitive: true
is_a: RO:0002081 ! before or simultaneous with
@@ -260062,8 +259891,8 @@ def: "inverse of has skeleton" []
subset: RO:0002259
xref: RO:0002576
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
-domain: CARO:0000003 ! connected anatomical structure
-range: CARO:0000003 ! connected anatomical structure
+domain: UBERON:0000061 ! anatomical structure
+range: UBERON:0000061 ! anatomical structure
is_a: part_of ! part_of
[Typedef]
@@ -260168,7 +259997,14 @@ id: term_tracker_item
name: term tracker item
namespace: external
namespace: uberon
+def: "An IRI or similar locator for a request or discussion of an ontology term." []
+comment: The 'tracker item' can associate a tracker with a specific ontology term.
xref: IAO:0000233
+property_value: IAO:0000111 "term tracker item" xsd:string
+property_value: IAO:0000112 "the URI for an OBI Terms ticket at sourceforge, such as https://sourceforge.net/p/obi/obi-terms/772/" xsd:string
+property_value: IAO:0000114 IAO:0000125
+property_value: IAO:0000117 "Person: Jie Zheng, Chris Stoeckert, Alan Ruttenberg" xsd:string
+property_value: IAO:0000119 "Person: Jie Zheng, Chris Stoeckert, Alan Ruttenberg" xsd:string
is_metadata_tag: true
is_class_level: true
diff --git a/patterns/definitions.owl b/patterns/definitions.owl
index 052ae3426..5c99c468e 100644
--- a/patterns/definitions.owl
+++ b/patterns/definitions.owl
@@ -7,8 +7,8 @@ Prefix(rdfs:=)
Ontology(
-
-Annotation(owl:versionInfo "2023-06-21")
+
+Annotation(owl:versionInfo "2023-07-19")
diff --git a/src/ontology/diffs/cl-diff.md b/src/ontology/diffs/cl-diff.md
index 3b06f584e..02eee8dfc 100644
--- a/src/ontology/diffs/cl-diff.md
+++ b/src/ontology/diffs/cl-diff.md
@@ -2,12 +2,12 @@
## Left
- Ontology IRI: `http://purl.obolibrary.org/obo/cl.owl`
-- Version IRI: `http://purl.obolibrary.org/obo/cl/releases/2023-05-22/cl.owl`
+- Version IRI: `http://purl.obolibrary.org/obo/cl/releases/2023-06-22/cl.owl`
- Loaded from: `http://purl.obolibrary.org/obo/cl.owl`
## Right
- Ontology IRI: `http://purl.obolibrary.org/obo/cl.owl`
-- Version IRI: `http://purl.obolibrary.org/obo/cl/releases/2023-06-22/cl.owl`
+- Version IRI: `http://purl.obolibrary.org/obo/cl/releases/2023-07-20/cl.owl`
- Loaded from: `file:/work/src/ontology/../../cl.owl`
### Ontology imports
@@ -16,6128 +16,7734 @@
### Ontology annotations
#### Removed
-- [versionInfo](http://www.w3.org/2002/07/owl#versionInfo) "2023-05-22"
-
-#### Added
- [versionInfo](http://www.w3.org/2002/07/owl#versionInfo) "2023-06-22"
-
-### ADP binding `http://purl.obolibrary.org/obo/GO_0043531`
-
#### Added
-- [ADP binding](http://purl.obolibrary.org/obo/GO_0043531) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Binding to ADP, adenosine 5'-diphosphate."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:jl"
+- [versionInfo](http://www.w3.org/2002/07/owl#versionInfo) "2023-07-20"
-- [ADP binding](http://purl.obolibrary.org/obo/GO_0043531) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0043531"
-- [ADP binding](http://purl.obolibrary.org/obo/GO_0043531) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "molecular_function"
+### 1st arch maxillary ectoderm `http://purl.obolibrary.org/obo/UBERON_0012313`
+#### Removed
+- [1st arch maxillary ectoderm](http://purl.obolibrary.org/obo/UBERON_0012313) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [ADP binding](http://purl.obolibrary.org/obo/GO_0043531) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "adenosine diphosphate binding"
-- [ADP binding](http://purl.obolibrary.org/obo/GO_0043531) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "adenosine 5'-diphosphate binding"
-- [ADP binding](http://purl.obolibrary.org/obo/GO_0043531) [label](http://www.w3.org/2000/01/rdf-schema#label) "ADP binding"
+### ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 `http://purl.obolibrary.org/obo/PR_000001408`
-- Class: [ADP binding](http://purl.obolibrary.org/obo/GO_0043531)
+#### Added
+- [ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1](http://purl.obolibrary.org/obo/PR_000001408) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (human)](http://purl.obolibrary.org/obo/PR_P28907)
-- [ADP binding](http://purl.obolibrary.org/obo/GO_0043531) EquivalentTo [binding](http://purl.obolibrary.org/obo/GO_0005488) and ([has input](http://purl.obolibrary.org/obo/RO_0002233) some [CHEBI_456216](http://purl.obolibrary.org/obo/CHEBI_456216))
-- [ADP binding](http://purl.obolibrary.org/obo/GO_0043531) SubClassOf [has input](http://purl.obolibrary.org/obo/RO_0002233) some [CHEBI_456216](http://purl.obolibrary.org/obo/CHEBI_456216)
+### B-cell lymphoma 6 protein `http://purl.obolibrary.org/obo/PR_000003450`
-- [ADP binding](http://purl.obolibrary.org/obo/GO_0043531) SubClassOf [binding](http://purl.obolibrary.org/obo/GO_0005488)
+#### Added
+- [B-cell lymphoma 6 protein](http://purl.obolibrary.org/obo/PR_000003450) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [B-cell lymphoma 6 protein (human)](http://purl.obolibrary.org/obo/PR_P41182)
-### ADP biosynthetic process `http://purl.obolibrary.org/obo/GO_0006172`
+### B-cell receptor CD22 `http://purl.obolibrary.org/obo/PR_000001288`
#### Added
-- [ADP biosynthetic process](http://purl.obolibrary.org/obo/GO_0006172) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process"
+- [B-cell receptor CD22](http://purl.obolibrary.org/obo/PR_000001288) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [B-cell receptor CD22 (human)](http://purl.obolibrary.org/obo/PR_P20273)
-- [ADP biosynthetic process](http://purl.obolibrary.org/obo/GO_0006172) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "ADP biosynthesis"
-- [ADP biosynthetic process](http://purl.obolibrary.org/obo/GO_0006172) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "ADP formation"
+### BFO_0000001 `http://purl.obolibrary.org/obo/BFO_0000001`
-- [ADP biosynthetic process](http://purl.obolibrary.org/obo/GO_0006172) [label](http://www.w3.org/2000/01/rdf-schema#label) "ADP biosynthetic process"
+#### Added
+- Class: [BFO_0000001](http://purl.obolibrary.org/obo/BFO_0000001)
-- [ADP biosynthetic process](http://purl.obolibrary.org/obo/GO_0006172) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "ADP anabolism"
-- [ADP biosynthetic process](http://purl.obolibrary.org/obo/GO_0006172) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0006172"
+### C-C chemokine receptor type 1 `http://purl.obolibrary.org/obo/PR_000001254`
-- [ADP biosynthetic process](http://purl.obolibrary.org/obo/GO_0006172) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The chemical reactions and pathways resulting in the formation of ADP, adenosine 5'-diphosphate."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:ai"
+#### Added
+- [C-C chemokine receptor type 1](http://purl.obolibrary.org/obo/PR_000001254) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [C-C chemokine receptor type 1 (human)](http://purl.obolibrary.org/obo/PR_P32246)
-- [ADP biosynthetic process](http://purl.obolibrary.org/obo/GO_0006172) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "ADP synthesis"
-- Class: [ADP biosynthetic process](http://purl.obolibrary.org/obo/GO_0006172)
+### C-C chemokine receptor type 2 `http://purl.obolibrary.org/obo/PR_000001199`
-- [ADP biosynthetic process](http://purl.obolibrary.org/obo/GO_0006172) EquivalentTo [biosynthetic process](http://purl.obolibrary.org/obo/GO_0009058) and ([has primary output](http://purl.obolibrary.org/obo/RO_0004008) some [CHEBI_456216](http://purl.obolibrary.org/obo/CHEBI_456216))
+#### Added
+- [C-C chemokine receptor type 2](http://purl.obolibrary.org/obo/PR_000001199) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [C-C chemokine receptor type 2 (human)](http://purl.obolibrary.org/obo/PR_P41597)
-- [ADP biosynthetic process](http://purl.obolibrary.org/obo/GO_0006172) SubClassOf [biosynthetic process](http://purl.obolibrary.org/obo/GO_0009058)
-- [ADP biosynthetic process](http://purl.obolibrary.org/obo/GO_0006172) SubClassOf [has primary output](http://purl.obolibrary.org/obo/RO_0004008) some [CHEBI_456216](http://purl.obolibrary.org/obo/CHEBI_456216)
+### C-C chemokine receptor type 3 `http://purl.obolibrary.org/obo/PR_000001255`
-- [ADP biosynthetic process](http://purl.obolibrary.org/obo/GO_0006172) SubClassOf [ADP metabolic process](http://purl.obolibrary.org/obo/GO_0046031)
+#### Added
+- [C-C chemokine receptor type 3](http://purl.obolibrary.org/obo/PR_000001255) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [C-C chemokine receptor type 3 (human)](http://purl.obolibrary.org/obo/PR_P51677)
-### ADP catabolic process `http://purl.obolibrary.org/obo/GO_0046032`
+### C-C chemokine receptor type 4 `http://purl.obolibrary.org/obo/PR_000001200`
#### Added
-- [ADP catabolic process](http://purl.obolibrary.org/obo/GO_0046032) [label](http://www.w3.org/2000/01/rdf-schema#label) "ADP catabolic process"
-
-- [ADP catabolic process](http://purl.obolibrary.org/obo/GO_0046032) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "ADP catabolism"
+- [C-C chemokine receptor type 4](http://purl.obolibrary.org/obo/PR_000001200) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [C-C chemokine receptor type 4 (human)](http://purl.obolibrary.org/obo/PR_P51679)
-- [ADP catabolic process](http://purl.obolibrary.org/obo/GO_0046032) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "ADP degradation"
-- [ADP catabolic process](http://purl.obolibrary.org/obo/GO_0046032) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The chemical reactions and pathways resulting in the breakdown of ADP, adenosine 5'-diphosphate."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:go_curators"
+### C-C chemokine receptor type 5 `http://purl.obolibrary.org/obo/PR_000001201`
-- [ADP catabolic process](http://purl.obolibrary.org/obo/GO_0046032) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0046032"
-
-- [ADP catabolic process](http://purl.obolibrary.org/obo/GO_0046032) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "ADP breakdown"
+#### Added
+- [C-C chemokine receptor type 5](http://purl.obolibrary.org/obo/PR_000001201) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [C-C chemokine receptor type 5 (human)](http://purl.obolibrary.org/obo/PR_P51681)
-- [ADP catabolic process](http://purl.obolibrary.org/obo/GO_0046032) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process"
-- Class: [ADP catabolic process](http://purl.obolibrary.org/obo/GO_0046032)
+### C-C chemokine receptor type 6 `http://purl.obolibrary.org/obo/PR_000001202`
-- [ADP catabolic process](http://purl.obolibrary.org/obo/GO_0046032) EquivalentTo [catabolic process](http://purl.obolibrary.org/obo/GO_0009056) and ([has primary input](http://purl.obolibrary.org/obo/RO_0004009) some [CHEBI_456216](http://purl.obolibrary.org/obo/CHEBI_456216))
+#### Added
+- [C-C chemokine receptor type 6](http://purl.obolibrary.org/obo/PR_000001202) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [C-C chemokine receptor type 6 (human)](http://purl.obolibrary.org/obo/PR_P51684)
-- [ADP catabolic process](http://purl.obolibrary.org/obo/GO_0046032) SubClassOf [ADP metabolic process](http://purl.obolibrary.org/obo/GO_0046031)
-- [ADP catabolic process](http://purl.obolibrary.org/obo/GO_0046032) SubClassOf [has primary input](http://purl.obolibrary.org/obo/RO_0004009) some [CHEBI_456216](http://purl.obolibrary.org/obo/CHEBI_456216)
+### C-C chemokine receptor type 7 `http://purl.obolibrary.org/obo/PR_000001203`
-- [ADP catabolic process](http://purl.obolibrary.org/obo/GO_0046032) SubClassOf [catabolic process](http://purl.obolibrary.org/obo/GO_0009056)
+#### Added
+- [C-C chemokine receptor type 7](http://purl.obolibrary.org/obo/PR_000001203) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [C-C chemokine receptor type 7 (human)](http://purl.obolibrary.org/obo/PR_P32248)
-### ADP metabolic process `http://purl.obolibrary.org/obo/GO_0046031`
+### C-C motif chemokine 3 `http://purl.obolibrary.org/obo/PR_000002123`
#### Added
-- [ADP metabolic process](http://purl.obolibrary.org/obo/GO_0046031) [label](http://www.w3.org/2000/01/rdf-schema#label) "ADP metabolic process"
-
-- [ADP metabolic process](http://purl.obolibrary.org/obo/GO_0046031) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process"
+- [C-C motif chemokine 3](http://purl.obolibrary.org/obo/PR_000002123) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [C-C motif chemokine 3 (human)](http://purl.obolibrary.org/obo/PR_P10147)
-- [ADP metabolic process](http://purl.obolibrary.org/obo/GO_0046031) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0046031"
-- [ADP metabolic process](http://purl.obolibrary.org/obo/GO_0046031) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "ADP metabolism"
+### C-X-C chemokine receptor type 1 `http://purl.obolibrary.org/obo/PR_000001256`
-- [ADP metabolic process](http://purl.obolibrary.org/obo/GO_0046031) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The chemical reactions and pathways involving ADP, adenosine 5'-diphosphate."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:go_curators"
-
-- Class: [ADP metabolic process](http://purl.obolibrary.org/obo/GO_0046031)
+#### Added
+- [C-X-C chemokine receptor type 1](http://purl.obolibrary.org/obo/PR_000001256) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [C-X-C chemokine receptor type 1 (human)](http://purl.obolibrary.org/obo/PR_P25024)
-- [ADP metabolic process](http://purl.obolibrary.org/obo/GO_0046031) EquivalentTo [metabolic process](http://purl.obolibrary.org/obo/GO_0008152) and ([has primary input or output](http://purl.obolibrary.org/obo/RO_0004007) some [CHEBI_456216](http://purl.obolibrary.org/obo/CHEBI_456216))
-- [ADP metabolic process](http://purl.obolibrary.org/obo/GO_0046031) SubClassOf [metabolic process](http://purl.obolibrary.org/obo/GO_0008152)
+### C-X-C chemokine receptor type 2 `http://purl.obolibrary.org/obo/PR_000001257`
-- [ADP metabolic process](http://purl.obolibrary.org/obo/GO_0046031) SubClassOf [has primary input or output](http://purl.obolibrary.org/obo/RO_0004007) some [CHEBI_456216](http://purl.obolibrary.org/obo/CHEBI_456216)
+#### Added
+- [C-X-C chemokine receptor type 2](http://purl.obolibrary.org/obo/PR_000001257) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [C-X-C chemokine receptor type 2 (human)](http://purl.obolibrary.org/obo/PR_P25025)
-### ADP transmembrane transporter activity `http://purl.obolibrary.org/obo/GO_0015217`
+### C-X-C chemokine receptor type 3 `http://purl.obolibrary.org/obo/PR_000001207`
#### Added
-- [ADP transmembrane transporter activity](http://purl.obolibrary.org/obo/GO_0015217) [label](http://www.w3.org/2000/01/rdf-schema#label) "ADP transmembrane transporter activity"
-
-- [ADP transmembrane transporter activity](http://purl.obolibrary.org/obo/GO_0015217) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Enables the transfer of ADP, adenosine diphosphate, from one side of a membrane to the other."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:ai"
+- [C-X-C chemokine receptor type 3](http://purl.obolibrary.org/obo/PR_000001207) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [C-X-C chemokine receptor type 3 (human)](http://purl.obolibrary.org/obo/PR_P49682)
-- [ADP transmembrane transporter activity](http://purl.obolibrary.org/obo/GO_0015217) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0015217"
-- [ADP transmembrane transporter activity](http://purl.obolibrary.org/obo/GO_0015217) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "molecular_function"
+### C-X-C chemokine receptor type 4 `http://purl.obolibrary.org/obo/PR_000001208`
-- Class: [ADP transmembrane transporter activity](http://purl.obolibrary.org/obo/GO_0015217)
-
-- [ADP transmembrane transporter activity](http://purl.obolibrary.org/obo/GO_0015217) EquivalentTo [transmembrane transporter activity](http://purl.obolibrary.org/obo/GO_0022857) and ([has primary input](http://purl.obolibrary.org/obo/RO_0004009) some [CHEBI_456216](http://purl.obolibrary.org/obo/CHEBI_456216))
+#### Added
+- [C-X-C chemokine receptor type 4](http://purl.obolibrary.org/obo/PR_000001208) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [C-X-C chemokine receptor type 4 (human)](http://purl.obolibrary.org/obo/PR_P61073)
-- [ADP transmembrane transporter activity](http://purl.obolibrary.org/obo/GO_0015217) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [ADP transport](http://purl.obolibrary.org/obo/GO_0015866)
-- [ADP transmembrane transporter activity](http://purl.obolibrary.org/obo/GO_0015217) SubClassOf [has primary input](http://purl.obolibrary.org/obo/RO_0004009) some [CHEBI_456216](http://purl.obolibrary.org/obo/CHEBI_456216)
+### C-X-C chemokine receptor type 5 `http://purl.obolibrary.org/obo/PR_000001209`
-- [ADP transmembrane transporter activity](http://purl.obolibrary.org/obo/GO_0015217) SubClassOf [transmembrane transporter activity](http://purl.obolibrary.org/obo/GO_0022857)
+#### Added
+- [C-X-C chemokine receptor type 5](http://purl.obolibrary.org/obo/PR_000001209) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [C-X-C chemokine receptor type 5 (human)](http://purl.obolibrary.org/obo/PR_P32302)
-### ADP transport `http://purl.obolibrary.org/obo/GO_0015866`
+### C-type lectin domain family 4 member C `http://purl.obolibrary.org/obo/PR_000001292`
#### Added
-- [ADP transport](http://purl.obolibrary.org/obo/GO_0015866) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0015866"
-
-- [ADP transport](http://purl.obolibrary.org/obo/GO_0015866) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process"
+- [C-type lectin domain family 4 member C](http://purl.obolibrary.org/obo/PR_000001292) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [C-type lectin domain family 4 member C (human)](http://purl.obolibrary.org/obo/PR_Q8WTT0)
-- [ADP transport](http://purl.obolibrary.org/obo/GO_0015866) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The directed movement of ADP, adenosine diphosphate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:ai"
-- [ADP transport](http://purl.obolibrary.org/obo/GO_0015866) [label](http://www.w3.org/2000/01/rdf-schema#label) "ADP transport"
+### C-type lectin domain family 4 member K `http://purl.obolibrary.org/obo/PR_000001293`
-- Class: [ADP transport](http://purl.obolibrary.org/obo/GO_0015866)
+#### Added
+- [C-type lectin domain family 4 member K](http://purl.obolibrary.org/obo/PR_000001293) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [C-type lectin domain family 4 member K (human)](http://purl.obolibrary.org/obo/PR_Q9UJ71)
-- [ADP transport](http://purl.obolibrary.org/obo/GO_0015866) EquivalentTo [transport](http://purl.obolibrary.org/obo/GO_0006810) and ([has primary input](http://purl.obolibrary.org/obo/RO_0004009) some [CHEBI_456216](http://purl.obolibrary.org/obo/CHEBI_456216))
-- [ADP transport](http://purl.obolibrary.org/obo/GO_0015866) SubClassOf [transport](http://purl.obolibrary.org/obo/GO_0006810)
+### C-type lectin domain family 6 member A `http://purl.obolibrary.org/obo/PR_000001806`
-- [ADP transport](http://purl.obolibrary.org/obo/GO_0015866) SubClassOf [has primary input](http://purl.obolibrary.org/obo/RO_0004009) some [CHEBI_456216](http://purl.obolibrary.org/obo/CHEBI_456216)
+#### Added
+- [C-type lectin domain family 6 member A](http://purl.obolibrary.org/obo/PR_000001806) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [C-type lectin domain family 6 member A (human)](http://purl.obolibrary.org/obo/PR_Q6EIG7)
-### ATP binding `http://purl.obolibrary.org/obo/GO_0005524`
+### C-type lectin domain family 7 member A `http://purl.obolibrary.org/obo/PR_000001807`
#### Added
-- [ATP binding](http://purl.obolibrary.org/obo/GO_0005524) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ISBN:0198506732"
+- [C-type lectin domain family 7 member A](http://purl.obolibrary.org/obo/PR_000001807) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [C-type lectin domain family 7 member A (human)](http://purl.obolibrary.org/obo/PR_Q9BXN2)
-- [ATP binding](http://purl.obolibrary.org/obo/GO_0005524) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0005524"
-- [ATP binding](http://purl.obolibrary.org/obo/GO_0005524) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-265682"
- - [label](http://www.w3.org/2000/01/rdf-schema#label) "KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel"
+### CCAAT/enhancer-binding protein alpha `http://purl.obolibrary.org/obo/PR_000005307`
-- [ATP binding](http://purl.obolibrary.org/obo/GO_0005524) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "Mg-ATP binding"
-
-- [ATP binding](http://purl.obolibrary.org/obo/GO_0005524) [label](http://www.w3.org/2000/01/rdf-schema#label) "ATP binding"
+#### Added
+- [CCAAT/enhancer-binding protein alpha](http://purl.obolibrary.org/obo/PR_000005307) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [CCAAT/enhancer-binding protein alpha (human)](http://purl.obolibrary.org/obo/PR_P49715)
-- [ATP binding](http://purl.obolibrary.org/obo/GO_0005524) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "MgATP binding"
-- [ATP binding](http://purl.obolibrary.org/obo/GO_0005524) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "molecular_function"
+### CCAAT/enhancer-binding protein epsilon `http://purl.obolibrary.org/obo/PR_000005310`
-- Class: [ATP binding](http://purl.obolibrary.org/obo/GO_0005524)
+#### Added
+- [CCAAT/enhancer-binding protein epsilon](http://purl.obolibrary.org/obo/PR_000005310) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [CCAAT/enhancer-binding protein epsilon (human)](http://purl.obolibrary.org/obo/PR_Q15744)
-- [ATP binding](http://purl.obolibrary.org/obo/GO_0005524) EquivalentTo [binding](http://purl.obolibrary.org/obo/GO_0005488) and ([has input](http://purl.obolibrary.org/obo/RO_0002233) some [CHEBI_30616](http://purl.obolibrary.org/obo/CHEBI_30616))
-- [ATP binding](http://purl.obolibrary.org/obo/GO_0005524) SubClassOf [binding](http://purl.obolibrary.org/obo/GO_0005488)
+### CD115-positive monocyte `http://purl.obolibrary.org/obo/CL_0001022`
+#### Removed
+- [CD115-positive monocyte](http://purl.obolibrary.org/obo/CL_0001022) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-- [ATP binding](http://purl.obolibrary.org/obo/GO_0005524) SubClassOf [has input](http://purl.obolibrary.org/obo/RO_0002233) some [CHEBI_30616](http://purl.obolibrary.org/obo/CHEBI_30616)
-### ATP biosynthetic process `http://purl.obolibrary.org/obo/GO_0006754`
+### CD11c-low plasmacytoid dendritic cell `http://purl.obolibrary.org/obo/CL_0000989`
+#### Removed
+- [CD11c-low plasmacytoid dendritic cell](http://purl.obolibrary.org/obo/CL_0000989) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-#### Added
-- [ATP biosynthetic process](http://purl.obolibrary.org/obo/GO_0006754) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "ATP formation"
-- [ATP biosynthetic process](http://purl.obolibrary.org/obo/GO_0006754) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0006754"
-- [ATP biosynthetic process](http://purl.obolibrary.org/obo/GO_0006754) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process"
+### CD11c-negative plasmacytoid dendritic cell `http://purl.obolibrary.org/obo/CL_0000991`
+#### Removed
+- [CD11c-negative plasmacytoid dendritic cell](http://purl.obolibrary.org/obo/CL_0000991) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-- [ATP biosynthetic process](http://purl.obolibrary.org/obo/GO_0006754) [label](http://www.w3.org/2000/01/rdf-schema#label) "ATP biosynthetic process"
-- [ATP biosynthetic process](http://purl.obolibrary.org/obo/GO_0006754) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "ATP regeneration"
-- [ATP biosynthetic process](http://purl.obolibrary.org/obo/GO_0006754) [has_alternative_id](http://www.geneontology.org/formats/oboInOwl#hasAlternativeId) "GO:0006758"
+### CD14-positive monocyte `http://purl.obolibrary.org/obo/CL_0001054`
+#### Removed
+- [CD14-positive monocyte](http://purl.obolibrary.org/obo/CL_0001054) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-- [ATP biosynthetic process](http://purl.obolibrary.org/obo/GO_0006754) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:go_curators"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ISBN:0198506732"
-- [ATP biosynthetic process](http://purl.obolibrary.org/obo/GO_0006754) [has_alternative_id](http://www.geneontology.org/formats/oboInOwl#hasAlternativeId) "GO:0006759"
+### CD16-negative, CD56-bright natural killer cell, human `http://purl.obolibrary.org/obo/CL_0000938`
+#### Removed
+- [CD16-negative, CD56-bright natural killer cell, human](http://purl.obolibrary.org/obo/CL_0000938) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-- [ATP biosynthetic process](http://purl.obolibrary.org/obo/GO_0006754) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "ATP synthesis"
-- [ATP biosynthetic process](http://purl.obolibrary.org/obo/GO_0006754) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "ATP anabolism"
-- [ATP biosynthetic process](http://purl.obolibrary.org/obo/GO_0006754) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "ATP biosynthesis"
+### CD16-positive, CD56-dim natural killer cell, human `http://purl.obolibrary.org/obo/CL_0000939`
+#### Removed
+- [CD16-positive, CD56-dim natural killer cell, human](http://purl.obolibrary.org/obo/CL_0000939) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-- Class: [ATP biosynthetic process](http://purl.obolibrary.org/obo/GO_0006754)
-- [ATP biosynthetic process](http://purl.obolibrary.org/obo/GO_0006754) EquivalentTo [biosynthetic process](http://purl.obolibrary.org/obo/GO_0009058) and ([has primary output](http://purl.obolibrary.org/obo/RO_0004008) some [CHEBI_30616](http://purl.obolibrary.org/obo/CHEBI_30616))
-- [ATP biosynthetic process](http://purl.obolibrary.org/obo/GO_0006754) SubClassOf [has primary output](http://purl.obolibrary.org/obo/RO_0004008) some [CHEBI_30616](http://purl.obolibrary.org/obo/CHEBI_30616)
+### CD25+ mast cell `http://purl.obolibrary.org/obo/CL_0011023`
+#### Removed
+- [CD25+ mast cell](http://purl.obolibrary.org/obo/CL_0011023) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-- [ATP biosynthetic process](http://purl.obolibrary.org/obo/GO_0006754) SubClassOf [biosynthetic process](http://purl.obolibrary.org/obo/GO_0009058)
-- [ATP biosynthetic process](http://purl.obolibrary.org/obo/GO_0006754) SubClassOf [ATP metabolic process](http://purl.obolibrary.org/obo/GO_0046034)
+### CD27-high, CD11b-high natural killer cell, mouse `http://purl.obolibrary.org/obo/CL_0002347`
+#### Removed
+- [CD27-high, CD11b-high natural killer cell, mouse](http://purl.obolibrary.org/obo/CL_0002347) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-### ATP hydrolysis activity `http://purl.obolibrary.org/obo/GO_0016887`
-#### Added
-- [ATP hydrolysis activity](http://purl.obolibrary.org/obo/GO_0016887) SubClassOf [has participant](http://purl.obolibrary.org/obo/RO_0000057) some [CHEBI_30616](http://purl.obolibrary.org/obo/CHEBI_30616)
-- [ATP hydrolysis activity](http://purl.obolibrary.org/obo/GO_0016887) SubClassOf [has participant](http://purl.obolibrary.org/obo/RO_0000057) some [CHEBI_456216](http://purl.obolibrary.org/obo/CHEBI_456216)
+### CD27-high, CD11b-low natural killer cell, mouse `http://purl.obolibrary.org/obo/CL_0002349`
+#### Removed
+- [CD27-high, CD11b-low natural killer cell, mouse](http://purl.obolibrary.org/obo/CL_0002349) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-### ATP metabolic process `http://purl.obolibrary.org/obo/GO_0046034`
-#### Added
-- [ATP metabolic process](http://purl.obolibrary.org/obo/GO_0046034) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process"
+### CD27-low, CD11b-high natural killer cell, mouse `http://purl.obolibrary.org/obo/CL_0002348`
+#### Removed
+- [CD27-low, CD11b-high natural killer cell, mouse](http://purl.obolibrary.org/obo/CL_0002348) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-- [ATP metabolic process](http://purl.obolibrary.org/obo/GO_0046034) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "ATP metabolism"
-- [ATP metabolic process](http://purl.obolibrary.org/obo/GO_0046034) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:go_curators"
-- [ATP metabolic process](http://purl.obolibrary.org/obo/GO_0046034) [label](http://www.w3.org/2000/01/rdf-schema#label) "ATP metabolic process"
+### CD27-low, CD11b-low immature natural killer cell, mouse `http://purl.obolibrary.org/obo/CL_0002345`
+#### Removed
+- [CD27-low, CD11b-low immature natural killer cell, mouse](http://purl.obolibrary.org/obo/CL_0002345) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-- [ATP metabolic process](http://purl.obolibrary.org/obo/GO_0046034) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0046034"
-- Class: [ATP metabolic process](http://purl.obolibrary.org/obo/GO_0046034)
-- [ATP metabolic process](http://purl.obolibrary.org/obo/GO_0046034) EquivalentTo [metabolic process](http://purl.obolibrary.org/obo/GO_0008152) and ([has primary input or output](http://purl.obolibrary.org/obo/RO_0004007) some [CHEBI_30616](http://purl.obolibrary.org/obo/CHEBI_30616))
+### CD34-negative, CD117-positive innate lymphoid cell, human `http://purl.obolibrary.org/obo/CL_0001072`
+#### Removed
+- [CD34-negative, CD117-positive innate lymphoid cell, human](http://purl.obolibrary.org/obo/CL_0001072) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-- [ATP metabolic process](http://purl.obolibrary.org/obo/GO_0046034) SubClassOf [has primary input or output](http://purl.obolibrary.org/obo/RO_0004007) some [CHEBI_30616](http://purl.obolibrary.org/obo/CHEBI_30616)
-- [ATP metabolic process](http://purl.obolibrary.org/obo/GO_0046034) SubClassOf [metabolic process](http://purl.obolibrary.org/obo/GO_0008152)
+### CD34-negative, CD41-positive, CD42-positive megakaryocyte cell `http://purl.obolibrary.org/obo/CL_0002026`
+#### Removed
+- [CD34-negative, CD41-positive, CD42-positive megakaryocyte cell](http://purl.obolibrary.org/obo/CL_0002026) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-### ATP transmembrane transporter activity `http://purl.obolibrary.org/obo/GO_0005347`
-#### Added
-- [ATP transmembrane transporter activity](http://purl.obolibrary.org/obo/GO_0005347) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0005347"
-- [ATP transmembrane transporter activity](http://purl.obolibrary.org/obo/GO_0005347) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Enables the transfer of ATP, adenosine triphosphate, from one side of a membrane to the other."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:ai"
+### CD34-positive, CD38-negative hematopoietic stem cell `http://purl.obolibrary.org/obo/CL_0001024`
+#### Removed
+- [CD34-positive, CD38-negative hematopoietic stem cell](http://purl.obolibrary.org/obo/CL_0001024) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-- [ATP transmembrane transporter activity](http://purl.obolibrary.org/obo/GO_0005347) [has_alternative_id](http://www.geneontology.org/formats/oboInOwl#hasAlternativeId) "GO:0005348"
-- [ATP transmembrane transporter activity](http://purl.obolibrary.org/obo/GO_0005347) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "molecular_function"
-- [ATP transmembrane transporter activity](http://purl.obolibrary.org/obo/GO_0005347) [label](http://www.w3.org/2000/01/rdf-schema#label) "ATP transmembrane transporter activity"
+### CD34-positive, CD38-positive common lymphoid progenitor `http://purl.obolibrary.org/obo/CL_0001021`
+#### Removed
+- [CD34-positive, CD38-positive common lymphoid progenitor](http://purl.obolibrary.org/obo/CL_0001021) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-- [ATP transmembrane transporter activity](http://purl.obolibrary.org/obo/GO_0005347) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-9717392"
- - [label](http://www.w3.org/2000/01/rdf-schema#label) "CALHM1:CALHM3 transports ATP from the cytosol to the extracellular region"
-- Class: [ATP transmembrane transporter activity](http://purl.obolibrary.org/obo/GO_0005347)
-- [ATP transmembrane transporter activity](http://purl.obolibrary.org/obo/GO_0005347) EquivalentTo [transmembrane transporter activity](http://purl.obolibrary.org/obo/GO_0022857) and ([has primary input](http://purl.obolibrary.org/obo/RO_0004009) some [CHEBI_30616](http://purl.obolibrary.org/obo/CHEBI_30616))
+### CD34-positive, CD38-positive megakaryocyte erythroid progenitor cell `http://purl.obolibrary.org/obo/CL_0002005`
+#### Removed
+- [CD34-positive, CD38-positive megakaryocyte erythroid progenitor cell](http://purl.obolibrary.org/obo/CL_0002005) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-- [ATP transmembrane transporter activity](http://purl.obolibrary.org/obo/GO_0005347) SubClassOf [transmembrane transporter activity](http://purl.obolibrary.org/obo/GO_0022857)
-- [ATP transmembrane transporter activity](http://purl.obolibrary.org/obo/GO_0005347) SubClassOf [has primary input](http://purl.obolibrary.org/obo/RO_0004009) some [CHEBI_30616](http://purl.obolibrary.org/obo/CHEBI_30616)
-- [ATP transmembrane transporter activity](http://purl.obolibrary.org/obo/GO_0005347) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [ATP transport](http://purl.obolibrary.org/obo/GO_0015867)
+### CD34-positive, CD41-positive, CD42-negative megakaryocyte progenitor cell `http://purl.obolibrary.org/obo/CL_0002025`
+#### Removed
+- [CD34-positive, CD41-positive, CD42-negative megakaryocyte progenitor cell](http://purl.obolibrary.org/obo/CL_0002025) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-### ATP transport `http://purl.obolibrary.org/obo/GO_0015867`
-#### Added
-- [ATP transport](http://purl.obolibrary.org/obo/GO_0015867) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The directed movement of ATP, adenosine triphosphate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:ai"
+### CD34-positive, CD41-positive, CD42-positive megakaryocyte progenitor cell `http://purl.obolibrary.org/obo/CL_0002023`
+#### Removed
+- [CD34-positive, CD41-positive, CD42-positive megakaryocyte progenitor cell](http://purl.obolibrary.org/obo/CL_0002023) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-- [ATP transport](http://purl.obolibrary.org/obo/GO_0015867) [label](http://www.w3.org/2000/01/rdf-schema#label) "ATP transport"
-- [ATP transport](http://purl.obolibrary.org/obo/GO_0015867) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0015867"
-- [ATP transport](http://purl.obolibrary.org/obo/GO_0015867) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process"
+### CD34-positive, CD56-positive, CD117-positive common innate lymphoid precursor, human `http://purl.obolibrary.org/obo/CL_0001074`
+#### Removed
+- [CD34-positive, CD56-positive, CD117-positive common innate lymphoid precursor, human](http://purl.obolibrary.org/obo/CL_0001074) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-- Class: [ATP transport](http://purl.obolibrary.org/obo/GO_0015867)
-- [ATP transport](http://purl.obolibrary.org/obo/GO_0015867) EquivalentTo [transport](http://purl.obolibrary.org/obo/GO_0006810) and ([has primary input](http://purl.obolibrary.org/obo/RO_0004009) some [CHEBI_30616](http://purl.obolibrary.org/obo/CHEBI_30616))
-- [ATP transport](http://purl.obolibrary.org/obo/GO_0015867) SubClassOf [transport](http://purl.obolibrary.org/obo/GO_0006810)
+### CD56-negative, CD161-positive immature natural killer cell, human `http://purl.obolibrary.org/obo/CL_0002344`
+#### Removed
+- [CD56-negative, CD161-positive immature natural killer cell, human](http://purl.obolibrary.org/obo/CL_0002344) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-- [ATP transport](http://purl.obolibrary.org/obo/GO_0015867) SubClassOf [has primary input](http://purl.obolibrary.org/obo/RO_0004009) some [CHEBI_30616](http://purl.obolibrary.org/obo/CHEBI_30616)
-### ATP-dependent peptidase activity `http://purl.obolibrary.org/obo/GO_0004176`
+### CD56-positive, CD161-positive immature natural killer cell, human `http://purl.obolibrary.org/obo/CL_0002338`
#### Removed
-- [ATP-dependent peptidase activity](http://purl.obolibrary.org/obo/GO_0004176) [has_alternative_id](http://www.geneontology.org/formats/oboInOwl#hasAlternativeId) "GO:0004280"
+- [CD56-positive, CD161-positive immature natural killer cell, human](http://purl.obolibrary.org/obo/CL_0002338) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-- [ATP-dependent peptidase activity](http://purl.obolibrary.org/obo/GO_0004176) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "ATP-dependent proteolysis"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:mah"
-- [ATP-dependent peptidase activity](http://purl.obolibrary.org/obo/GO_0004176) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0004176"
-- [ATP-dependent peptidase activity](http://purl.obolibrary.org/obo/GO_0004176) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Catalysis of the hydrolysis of peptide bonds, driven by ATP hydrolysis."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:mah"
+### CD7-negative lymphoid progenitor cell `http://purl.obolibrary.org/obo/CL_0001027`
+#### Removed
+- [CD7-negative lymphoid progenitor cell](http://purl.obolibrary.org/obo/CL_0001027) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-- [ATP-dependent peptidase activity](http://purl.obolibrary.org/obo/GO_0004176) [term tracker item](http://purl.obolibrary.org/obo/IAO_0000233) "https://github.com/geneontology/go-ontology/issues/21612"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI)
-- [ATP-dependent peptidase activity](http://purl.obolibrary.org/obo/GO_0004176) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-9698929"
- - [label](http://www.w3.org/2000/01/rdf-schema#label) "pPR-AP:pAP cleaves the MCP:pPR-AP:pAP Complex"
-- [ATP-dependent peptidase activity](http://purl.obolibrary.org/obo/GO_0004176) [label](http://www.w3.org/2000/01/rdf-schema#label) "ATP-dependent peptidase activity"
+### CD7-positive lymphoid progenitor cell `http://purl.obolibrary.org/obo/CL_0001028`
+#### Removed
+- [CD7-positive lymphoid progenitor cell](http://purl.obolibrary.org/obo/CL_0001028) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-- [ATP-dependent peptidase activity](http://purl.obolibrary.org/obo/GO_0004176) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "molecular_function"
-- Class: [ATP-dependent peptidase activity](http://purl.obolibrary.org/obo/GO_0004176)
-- [ATP-dependent peptidase activity](http://purl.obolibrary.org/obo/GO_0004176) EquivalentTo [peptidase activity](http://purl.obolibrary.org/obo/GO_0008233) and ([has part](http://purl.obolibrary.org/obo/BFO_0000051) some [ATP hydrolysis activity](http://purl.obolibrary.org/obo/GO_0016887))
+### CD71-negative, GlyA-positive orthochromatic erythroblast `http://purl.obolibrary.org/obo/CL_0002018`
+#### Removed
+- [CD71-negative, GlyA-positive orthochromatic erythroblast](http://purl.obolibrary.org/obo/CL_0002018) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-- [ATP-dependent peptidase activity](http://purl.obolibrary.org/obo/GO_0004176) SubClassOf [peptidase activity](http://purl.obolibrary.org/obo/GO_0008233)
-- [ATP-dependent peptidase activity](http://purl.obolibrary.org/obo/GO_0004176) SubClassOf [ATP-dependent activity](http://purl.obolibrary.org/obo/GO_0140657)
+### CD9-positive, CD41-positive megakaryocyte cell `http://purl.obolibrary.org/obo/CL_0002027`
+#### Removed
+- [CD9-positive, CD41-positive megakaryocyte cell](http://purl.obolibrary.org/obo/CL_0002027) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-### Archaea `http://purl.obolibrary.org/obo/NCBITaxon_2157`
-#### Added
-- [Archaea](http://purl.obolibrary.org/obo/NCBITaxon_2157) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:36748408"
+### CNS neuron (sensu Nematoda and Protostomia) `http://purl.obolibrary.org/obo/CL_0000028`
+#### Removed
+- [CNS neuron (sensu Nematoda and Protostomia)](http://purl.obolibrary.org/obo/CL_0000028) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [Archaea](http://purl.obolibrary.org/obo/NCBITaxon_2157) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:32628106"
-### Atg12 conjugating enzyme activity `http://purl.obolibrary.org/obo/GO_0061651`
+### CNS neuron (sensu Vertebrata) `http://purl.obolibrary.org/obo/CL_0000117`
#### Removed
-- [Atg12 conjugating enzyme activity](http://purl.obolibrary.org/obo/GO_0061651) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "E2"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dph"
+- [CNS neuron (sensu Vertebrata)](http://purl.obolibrary.org/obo/CL_0000117) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [Atg12 conjugating enzyme activity](http://purl.obolibrary.org/obo/GO_0061651) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Isoenergetic transfer of Atg12 from one protein to another via the reaction X-Atg12 + Y -> Y-Atg12 + X, where both the X-Atg12 and Y-Atg12 linkages are thioester bonds between the C-terminal amino acid of Atg12 and a sulfhydryl side group of a cysteine residue."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dph"
-#### Added
-- [Atg12 conjugating enzyme activity](http://purl.obolibrary.org/obo/GO_0061651) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Isoenergetic transfer of Atg12 from one protein to another via the reaction X-Atg12 + Y = Y-Atg12 + X, where both the X-Atg12 and Y-Atg12 linkages are thioester bonds between the C-terminal amino acid of Atg12 and a sulfhydryl side group of a cysteine residue."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dph"
-- [Atg12 conjugating enzyme activity](http://purl.obolibrary.org/obo/GO_0061651) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "E2"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dph"
+### CX3C chemokine receptor 1 `http://purl.obolibrary.org/obo/PR_000001206`
+#### Added
+- [CX3C chemokine receptor 1](http://purl.obolibrary.org/obo/PR_000001206) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [CX3C chemokine receptor 1 (human)](http://purl.obolibrary.org/obo/PR_P49238)
-### Atg12 ligase activity `http://purl.obolibrary.org/obo/GO_0061660`
-#### Removed
-- [Atg12 ligase activity](http://purl.obolibrary.org/obo/GO_0061660) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "E3"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dph"
-- [Atg12 ligase activity](http://purl.obolibrary.org/obo/GO_0061660) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Catalysis of the transfer of Atg12 to a substrate protein via the reaction X-Atg12 + S --> X + S-Atg12, where X is either an E2 or E3 enzyme, the X-Atg12 linkage is a thioester bond, and the S-Atg12 linkage is an isopeptide bond between the C-terminal amino acid of Atg12 and the epsilon-amino group of lysine residues in the substrate."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dph"
+### D(1A) dopamine receptor `http://purl.obolibrary.org/obo/PR_000001175`
#### Added
-- [Atg12 ligase activity](http://purl.obolibrary.org/obo/GO_0061660) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "E3"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dph"
+- [D(1A) dopamine receptor](http://purl.obolibrary.org/obo/PR_000001175) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [D(1A) dopamine receptor (human)](http://purl.obolibrary.org/obo/PR_P21728)
-- [Atg12 ligase activity](http://purl.obolibrary.org/obo/GO_0061660) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Catalysis of the transfer of Atg12 to a substrate protein via the reaction X-Atg12 + S = X + S-Atg12, where X is either an E2 or E3 enzyme, the X-Atg12 linkage is a thioester bond, and the S-Atg12 linkage is an isopeptide bond between the C-terminal amino acid of Atg12 and the epsilon-amino group of lysine residues in the substrate."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dph"
+
+### D(2) dopamine receptor `http://purl.obolibrary.org/obo/PR_000001177`
+
+#### Added
+- [D(2) dopamine receptor](http://purl.obolibrary.org/obo/PR_000001177) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [D(2) dopamine receptor (human)](http://purl.obolibrary.org/obo/PR_P14416)
-### Atg12 transferase activity `http://purl.obolibrary.org/obo/GO_0019777`
+### DN1 thymic pro-T cell `http://purl.obolibrary.org/obo/CL_0000894`
#### Removed
-- [Atg12 transferase activity](http://purl.obolibrary.org/obo/GO_0019777) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Catalysis of the transfer of ATG12 from one protein to another via the reaction X-ATG12 + Y --> Y-ATG12 + X, where both X-ATG12 and Y-ATG12 are covalent linkages."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:mah"
+- [DN1 thymic pro-T cell](http://purl.obolibrary.org/obo/CL_0000894) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:12826404"
-#### Added
-- [Atg12 transferase activity](http://purl.obolibrary.org/obo/GO_0019777) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Catalysis of the transfer of ATG12 from one protein to another via the reaction X-ATG12 + Y = Y-ATG12 + X, where both X-ATG12 and Y-ATG12 are covalent linkages."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:mah"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:12826404"
+### DN2 thymocyte `http://purl.obolibrary.org/obo/CL_0000806`
+#### Removed
+- [DN2 thymocyte](http://purl.obolibrary.org/obo/CL_0000806) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-### B cell `http://purl.obolibrary.org/obo/CL_0000236`
-#### Added
-- [B cell](http://purl.obolibrary.org/obo/CL_0000236) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [general_cell_types_upper_slim](http://purl.obolibrary.org/obo/cl#general_cell_types_upper_slim)
+### DN3 thymocyte `http://purl.obolibrary.org/obo/CL_0000807`
+#### Removed
+- [DN3 thymocyte](http://purl.obolibrary.org/obo/CL_0000807) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-### Bacteria `http://purl.obolibrary.org/obo/NCBITaxon_2`
-#### Added
-- [Bacteria](http://purl.obolibrary.org/obo/NCBITaxon_2) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:36748408"
+### DN4 thymocyte `http://purl.obolibrary.org/obo/CL_0000808`
+#### Removed
+- [DN4 thymocyte](http://purl.obolibrary.org/obo/CL_0000808) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-- [Bacteria](http://purl.obolibrary.org/obo/NCBITaxon_2) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:32628106"
-### C-C motif chemokine 3 `http://purl.obolibrary.org/obo/PR_000002123`
+### DNA nucleotidylexotransferase `http://purl.obolibrary.org/obo/PR_000006611`
#### Added
-- [C-C motif chemokine 3](http://purl.obolibrary.org/obo/PR_000002123) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "PAT 464.1"
+- [DNA nucleotidylexotransferase](http://purl.obolibrary.org/obo/PR_000006611) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [DNA nucleotidylexotransferase (human)](http://purl.obolibrary.org/obo/PR_P04053)
+
-- [C-C motif chemokine 3](http://purl.obolibrary.org/obo/PR_000002123) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "SIS-alpha"
+### Dx5-negative, NK1.1-positive immature natural killer cell, mouse `http://purl.obolibrary.org/obo/CL_0002346`
+#### Removed
+- [Dx5-negative, NK1.1-positive immature natural killer cell, mouse](http://purl.obolibrary.org/obo/CL_0002346) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-- [C-C motif chemokine 3](http://purl.obolibrary.org/obo/PR_000002123) [id](http://www.geneontology.org/formats/oboInOwl#id) "PR:000002123"
-- [C-C motif chemokine 3](http://purl.obolibrary.org/obo/PR_000002123) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "G0S19-1"
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [Gene-based](http://purl.obolibrary.org/obo/pr#Gene-based)
-- [C-C motif chemokine 3](http://purl.obolibrary.org/obo/PR_000002123) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "Category=gene."
+### GCIs
+#### Removed
+- [megakaryocyte](http://purl.obolibrary.org/obo/CL_0000556) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [lung connective tissue](http://purl.obolibrary.org/obo/UBERON_0000114)) SubClassOf [lung megakaryocyte](http://purl.obolibrary.org/obo/CL_4033018)
-- [C-C motif chemokine 3](http://purl.obolibrary.org/obo/PR_000002123) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "SCYA3"
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [Gene-based](http://purl.obolibrary.org/obo/pr#Gene-based)
+#### Added
+- [organogenesis stage](http://purl.obolibrary.org/obo/UBERON_0000111) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [Tetrapoda](http://purl.obolibrary.org/obo/NCBITaxon_32523)) SubClassOf [preceded by](http://purl.obolibrary.org/obo/BFO_0000062) some [neurula stage](http://purl.obolibrary.org/obo/UBERON_0000110)
-- [C-C motif chemokine 3](http://purl.obolibrary.org/obo/PR_000002123) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "L2G25B"
-- [C-C motif chemokine 3](http://purl.obolibrary.org/obo/PR_000002123) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "MIP-1-alpha"
+### GlyA-positive erythrocyte `http://purl.obolibrary.org/obo/CL_0002021`
+#### Removed
+- [GlyA-positive erythrocyte](http://purl.obolibrary.org/obo/CL_0002021) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-- [C-C motif chemokine 3](http://purl.obolibrary.org/obo/PR_000002123) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "macrophage inflammatory protein 1-alpha"
-- [C-C motif chemokine 3](http://purl.obolibrary.org/obo/PR_000002123) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "small-inducible cytokine A3"
-- [C-C motif chemokine 3](http://purl.obolibrary.org/obo/PR_000002123) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "protein"
+### H1 horizontal cell `http://purl.obolibrary.org/obo/CL_0004217`
-- [C-C motif chemokine 3](http://purl.obolibrary.org/obo/PR_000002123) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "MIP1A"
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [Gene-based](http://purl.obolibrary.org/obo/pr#Gene-based)
+#### Added
+- [H1 horizontal cell](http://purl.obolibrary.org/obo/CL_0004217) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "H1"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
-- [C-C motif chemokine 3](http://purl.obolibrary.org/obo/PR_000002123) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "SIS-beta"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1038/s41598-020-66092-9"
-- [C-C motif chemokine 3](http://purl.obolibrary.org/obo/PR_000002123) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "tonsillar lymphocyte LD78 alpha protein"
-- [C-C motif chemokine 3](http://purl.obolibrary.org/obo/PR_000002123) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A C-C motif chemokine 3/4 that is a translation product of the human CCL3 gene or a 1:1 ortholog thereof."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PRO:WCB"
+### H2 horizontal cell `http://purl.obolibrary.org/obo/CL_0004218`
-- [C-C motif chemokine 3](http://purl.obolibrary.org/obo/PR_000002123) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "heparin-binding chemotaxis protein"
+#### Added
+- [H2 horizontal cell](http://purl.obolibrary.org/obo/CL_0004218) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "H2"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
-- [C-C motif chemokine 3](http://purl.obolibrary.org/obo/PR_000002123) [label](http://www.w3.org/2000/01/rdf-schema#label) "C-C motif chemokine 3"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1038/s41598-020-66092-9"
-- [C-C motif chemokine 3](http://purl.obolibrary.org/obo/PR_000002123) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "G0/G1 switch regulatory protein 19-1"
-- [C-C motif chemokine 3](http://purl.obolibrary.org/obo/PR_000002123) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "TY-5"
+### ILC1, human `http://purl.obolibrary.org/obo/CL_0001077`
+#### Removed
+- [ILC1, human](http://purl.obolibrary.org/obo/CL_0001077) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-- [C-C motif chemokine 3](http://purl.obolibrary.org/obo/PR_000002123) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "CCL3"
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [PRO-short-label](http://purl.obolibrary.org/obo/pr#PRO-short-label)
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PRO:DNx"
-- Class: [C-C motif chemokine 3](http://purl.obolibrary.org/obo/PR_000002123)
+### Kit and Sca1-positive hematopoietic stem cell `http://purl.obolibrary.org/obo/CL_0001008`
+#### Removed
+- [Kit and Sca1-positive hematopoietic stem cell](http://purl.obolibrary.org/obo/CL_0001008) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-- [C-C motif chemokine 3](http://purl.obolibrary.org/obo/PR_000002123) SubClassOf [C-C motif chemokine 3/4](http://purl.obolibrary.org/obo/PR_000001998)
-### C-C motif chemokine 3 (human) `http://purl.obolibrary.org/obo/PR_P10147`
+### Kit-negative, Ly-76 high orthochromatophilic erythroblasts `http://purl.obolibrary.org/obo/CL_0002017`
+#### Removed
+- [Kit-negative, Ly-76 high orthochromatophilic erythroblasts](http://purl.obolibrary.org/obo/CL_0002017) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-#### Added
-- [C-C motif chemokine 3 (human)](http://purl.obolibrary.org/obo/PR_P10147) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A C-C motif chemokine 3 that is encoded in the genome of human."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PRO:WCB"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "UniProtKB:P10147"
-- [C-C motif chemokine 3 (human)](http://purl.obolibrary.org/obo/PR_P10147) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "G0S19-1"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "UniProtKB:P10147"
+### Kit-positive macrophage dendritic cell progenitor `http://purl.obolibrary.org/obo/CL_0002011`
+#### Removed
+- [Kit-positive macrophage dendritic cell progenitor](http://purl.obolibrary.org/obo/CL_0002011) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [Gene-based](http://purl.obolibrary.org/obo/pr#Gene-based)
-- [C-C motif chemokine 3 (human)](http://purl.obolibrary.org/obo/PR_P10147) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "Category=organism-gene."
-- [C-C motif chemokine 3 (human)](http://purl.obolibrary.org/obo/PR_P10147) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "tonsillar lymphocyte LD78 alpha protein (human)"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "UniProtKB:P10147"
+### Kit-positive megakaryocyte progenitor cell `http://purl.obolibrary.org/obo/CL_0002024`
+#### Removed
+- [Kit-positive megakaryocyte progenitor cell](http://purl.obolibrary.org/obo/CL_0002024) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-- [C-C motif chemokine 3 (human)](http://purl.obolibrary.org/obo/PR_P10147) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "G0/G1 switch regulatory protein 19-1 (human)"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "UniProtKB:P10147"
-- [C-C motif chemokine 3 (human)](http://purl.obolibrary.org/obo/PR_P10147) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "protein"
-- [C-C motif chemokine 3 (human)](http://purl.obolibrary.org/obo/PR_P10147) [label](http://www.w3.org/2000/01/rdf-schema#label) "C-C motif chemokine 3 (human)"
+### Kit-positive, CD34-negative megakaryocyte erythroid progenitor cell `http://purl.obolibrary.org/obo/CL_0002006`
+#### Removed
+- [Kit-positive, CD34-negative megakaryocyte erythroid progenitor cell](http://purl.obolibrary.org/obo/CL_0002006) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-- [C-C motif chemokine 3 (human)](http://purl.obolibrary.org/obo/PR_P10147) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "MIP1A"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "UniProtKB:P10147"
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [Gene-based](http://purl.obolibrary.org/obo/pr#Gene-based)
-- [C-C motif chemokine 3 (human)](http://purl.obolibrary.org/obo/PR_P10147) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "hCCL3"
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [PRO-short-label](http://purl.obolibrary.org/obo/pr#PRO-short-label)
+### Kit-positive, Sca1-positive common lymphoid progenitor `http://purl.obolibrary.org/obo/CL_0001025`
+#### Removed
+- [Kit-positive, Sca1-positive common lymphoid progenitor](http://purl.obolibrary.org/obo/CL_0001025) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PRO:DNx"
-- [C-C motif chemokine 3 (human)](http://purl.obolibrary.org/obo/PR_P10147) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "macrophage inflammatory protein 1-alpha (human)"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "UniProtKB:P10147"
-- [C-C motif chemokine 3 (human)](http://purl.obolibrary.org/obo/PR_P10147) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "UniProtKB:P10147"
+### Kupffer cell `http://purl.obolibrary.org/obo/CL_0000091`
+#### Removed
+- [Kupffer cell](http://purl.obolibrary.org/obo/CL_0000091) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-- [C-C motif chemokine 3 (human)](http://purl.obolibrary.org/obo/PR_P10147) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "CCL3"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "UniProtKB:P10147"
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [Gene-based](http://purl.obolibrary.org/obo/pr#Gene-based)
-- [C-C motif chemokine 3 (human)](http://purl.obolibrary.org/obo/PR_P10147) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "SCYA3"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "UniProtKB:P10147"
+### L-selectin `http://purl.obolibrary.org/obo/PR_000001318`
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [Gene-based](http://purl.obolibrary.org/obo/pr#Gene-based)
+#### Added
+- [L-selectin](http://purl.obolibrary.org/obo/PR_000001318) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [L-selectin (human)](http://purl.obolibrary.org/obo/PR_P14151)
-- [C-C motif chemokine 3 (human)](http://purl.obolibrary.org/obo/PR_P10147) [id](http://www.geneontology.org/formats/oboInOwl#id) "PR:P10147"
-- [C-C motif chemokine 3 (human)](http://purl.obolibrary.org/obo/PR_P10147) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "MIP-1-alpha (human)"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "UniProtKB:P10147"
+### L2/3 bipolar vip GABAergic cortical interneuron (Mmus) `http://purl.obolibrary.org/obo/CL_4023007`
-- [C-C motif chemokine 3 (human)](http://purl.obolibrary.org/obo/PR_P10147) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "small-inducible cytokine A3 (human)"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "UniProtKB:P10147"
+#### Added
+- [L2/3 bipolar vip GABAergic cortical interneuron (Mmus)](http://purl.obolibrary.org/obo/CL_4023007) [symbol](http://purl.obolibrary.org/obo/IAO_0000028) "L2/3 bipolar vip interneuron (Mus)"
-- [C-C motif chemokine 3 (human)](http://purl.obolibrary.org/obo/PR_P10147) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "SIS-beta (human)"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "UniProtKB:P10147"
-- [C-C motif chemokine 3 (human)](http://purl.obolibrary.org/obo/PR_P10147) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "PAT 464.1 (human)"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "UniProtKB:P10147"
+### L2/3 intratelencephalic projecting glutamatergic neuron of the primary motor cortex `http://purl.obolibrary.org/obo/CL_4023047`
-- Class: [C-C motif chemokine 3 (human)](http://purl.obolibrary.org/obo/PR_P10147)
+#### Added
+- [L2/3 intratelencephalic projecting glutamatergic neuron of the primary motor cortex](http://purl.obolibrary.org/obo/CL_4023047) [symbol](http://purl.obolibrary.org/obo/IAO_0000028) "L2/3 IT glut MOp"
-- [C-C motif chemokine 3 (human)](http://purl.obolibrary.org/obo/PR_P10147) EquivalentTo [C-C motif chemokine 3](http://purl.obolibrary.org/obo/PR_000002123) and ([only in taxon](http://purl.obolibrary.org/obo/RO_0002160) some [Homo sapiens](http://purl.obolibrary.org/obo/NCBITaxon_9606))
-- [C-C motif chemokine 3 (human)](http://purl.obolibrary.org/obo/PR_P10147) SubClassOf [Homo sapiens protein](http://purl.obolibrary.org/obo/PR_000029067)
+### L2/3-6 intratelencephalic projecting glutamatergic cortical neuron `http://purl.obolibrary.org/obo/CL_4023040`
-- [C-C motif chemokine 3 (human)](http://purl.obolibrary.org/obo/PR_P10147) SubClassOf [C-C motif chemokine 3](http://purl.obolibrary.org/obo/PR_000002123)
+#### Added
+- [L2/3-6 intratelencephalic projecting glutamatergic cortical neuron](http://purl.obolibrary.org/obo/CL_4023040) [symbol](http://purl.obolibrary.org/obo/IAO_0000028) "L2/3-6 IT glut"
-### C-C motif chemokine 3 (mouse) `http://purl.obolibrary.org/obo/PR_P10855`
+### L2/3/5 fan Martinotti sst GABAergic cortical interneuron (Mmus) `http://purl.obolibrary.org/obo/CL_4023030`
#### Added
-- [C-C motif chemokine 3 (mouse)](http://purl.obolibrary.org/obo/PR_P10855) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "protein"
+- [L2/3/5 fan Martinotti sst GABAergic cortical interneuron (Mmus)](http://purl.obolibrary.org/obo/CL_4023030) [symbol](http://purl.obolibrary.org/obo/IAO_0000028) "L2/3/5 fan Martinotti sst interneuron (Mus)"
-- [C-C motif chemokine 3 (mouse)](http://purl.obolibrary.org/obo/PR_P10855) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "UniProtKB:P10855"
-- [C-C motif chemokine 3 (mouse)](http://purl.obolibrary.org/obo/PR_P10855) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "Category=organism-gene."
+### L4 sst GABAergic cortical interneuron (Mmus) `http://purl.obolibrary.org/obo/CL_4023031`
-- [C-C motif chemokine 3 (mouse)](http://purl.obolibrary.org/obo/PR_P10855) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "heparin-binding chemotaxis protein (mouse)"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "UniProtKB:P10855"
+#### Added
+- [L4 sst GABAergic cortical interneuron (Mmus)](http://purl.obolibrary.org/obo/CL_4023031) [symbol](http://purl.obolibrary.org/obo/IAO_0000028) "L4 sst interneuron (Mus)"
-- [C-C motif chemokine 3 (mouse)](http://purl.obolibrary.org/obo/PR_P10855) [id](http://www.geneontology.org/formats/oboInOwl#id) "PR:P10855"
-- [C-C motif chemokine 3 (mouse)](http://purl.obolibrary.org/obo/PR_P10855) [label](http://www.w3.org/2000/01/rdf-schema#label) "C-C motif chemokine 3 (mouse)"
+### L4/5 intratelencephalic projecting glutamatergic neuron of the primary motor cortex `http://purl.obolibrary.org/obo/CL_4023048`
-- [C-C motif chemokine 3 (mouse)](http://purl.obolibrary.org/obo/PR_P10855) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "Scya3"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "UniProtKB:P10855"
+#### Added
+- [L4/5 intratelencephalic projecting glutamatergic neuron of the primary motor cortex](http://purl.obolibrary.org/obo/CL_4023048) [symbol](http://purl.obolibrary.org/obo/IAO_0000028) "L4/5 IT glut MOp"
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [Gene-based](http://purl.obolibrary.org/obo/pr#Gene-based)
-- [C-C motif chemokine 3 (mouse)](http://purl.obolibrary.org/obo/PR_P10855) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "small-inducible cytokine A3 (mouse)"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "UniProtKB:P10855"
+### L5 T-Martinotti sst GABAergic cortical interneuron (Mmus) `http://purl.obolibrary.org/obo/CL_4023027`
-- [C-C motif chemokine 3 (mouse)](http://purl.obolibrary.org/obo/PR_P10855) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "SIS-alpha (mouse)"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "UniProtKB:P10855"
+#### Added
+- [L5 T-Martinotti sst GABAergic cortical interneuron (Mmus)](http://purl.obolibrary.org/obo/CL_4023027) [symbol](http://purl.obolibrary.org/obo/IAO_0000028) "L5 T Martinotti sst interneuron (Mus)"
-- [C-C motif chemokine 3 (mouse)](http://purl.obolibrary.org/obo/PR_P10855) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "Ccl3"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "UniProtKB:P10855"
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [Gene-based](http://purl.obolibrary.org/obo/pr#Gene-based)
+### L5 extratelencephalic projecting glutamatergic cortical neuron `http://purl.obolibrary.org/obo/CL_4023041`
-- [C-C motif chemokine 3 (mouse)](http://purl.obolibrary.org/obo/PR_P10855) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "Mip1a"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "UniProtKB:P10855"
+#### Added
+- [L5 extratelencephalic projecting glutamatergic cortical neuron](http://purl.obolibrary.org/obo/CL_4023041) [symbol](http://purl.obolibrary.org/obo/IAO_0000028) "L5 ET glut"
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [Gene-based](http://purl.obolibrary.org/obo/pr#Gene-based)
-- [C-C motif chemokine 3 (mouse)](http://purl.obolibrary.org/obo/PR_P10855) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "TY-5 (mouse)"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "UniProtKB:P10855"
+### L5 intratelencephalic projecting glutamatergic neuron of the primary motor cortex `http://purl.obolibrary.org/obo/CL_4023049`
-- [C-C motif chemokine 3 (mouse)](http://purl.obolibrary.org/obo/PR_P10855) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "macrophage inflammatory protein 1-alpha (mouse)"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "UniProtKB:P10855"
+#### Added
+- [L5 intratelencephalic projecting glutamatergic neuron of the primary motor cortex](http://purl.obolibrary.org/obo/CL_4023049) [symbol](http://purl.obolibrary.org/obo/IAO_0000028) "L5 IT glut MOp"
-- [C-C motif chemokine 3 (mouse)](http://purl.obolibrary.org/obo/PR_P10855) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "MIP-1-alpha (mouse)"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "UniProtKB:P10855"
-- [C-C motif chemokine 3 (mouse)](http://purl.obolibrary.org/obo/PR_P10855) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A C-C motif chemokine 3 that is encoded in the genome of mouse."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PRO:WCB"
+### L5 non-Martinotti sst GABAergic cortical interneuron (Mmus) `http://purl.obolibrary.org/obo/CL_4023028`
-- [C-C motif chemokine 3 (mouse)](http://purl.obolibrary.org/obo/PR_P10855) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "mCCL3"
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [PRO-short-label](http://purl.obolibrary.org/obo/pr#PRO-short-label)
+#### Added
+- [L5 non-Martinotti sst GABAergic cortical interneuron (Mmus)](http://purl.obolibrary.org/obo/CL_4023028) [symbol](http://purl.obolibrary.org/obo/IAO_0000028) "L5 non-Martinotti sst interneuron (Mus)"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PRO:DNx"
-- [C-C motif chemokine 3 (mouse)](http://purl.obolibrary.org/obo/PR_P10855) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "L2G25B (mouse)"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "UniProtKB:P10855"
+### L5 vip cortical GABAergic interneuron (Mmus) `http://purl.obolibrary.org/obo/CL_4023014`
-- Class: [C-C motif chemokine 3 (mouse)](http://purl.obolibrary.org/obo/PR_P10855)
+#### Added
+- [L5 vip cortical GABAergic interneuron (Mmus)](http://purl.obolibrary.org/obo/CL_4023014) [symbol](http://purl.obolibrary.org/obo/IAO_0000028) "L5 vip interneuron (Mus)"
-- [C-C motif chemokine 3 (mouse)](http://purl.obolibrary.org/obo/PR_P10855) EquivalentTo [C-C motif chemokine 3](http://purl.obolibrary.org/obo/PR_000002123) and ([only in taxon](http://purl.obolibrary.org/obo/RO_0002160) some [Mus musculus](http://purl.obolibrary.org/obo/NCBITaxon_10090))
-- [C-C motif chemokine 3 (mouse)](http://purl.obolibrary.org/obo/PR_P10855) SubClassOf [Mus musculus protein](http://purl.obolibrary.org/obo/PR_000029032)
+### L5,6 neurogliaform lamp5 GABAergic cortical interneuron (Mmus) `http://purl.obolibrary.org/obo/CL_4023023`
-- [C-C motif chemokine 3 (mouse)](http://purl.obolibrary.org/obo/PR_P10855) SubClassOf [C-C motif chemokine 3](http://purl.obolibrary.org/obo/PR_000002123)
+#### Added
+- [L5,6 neurogliaform lamp5 GABAergic cortical interneuron (Mmus)](http://purl.obolibrary.org/obo/CL_4023023) [symbol](http://purl.obolibrary.org/obo/IAO_0000028) "L5,6 NGC Lamp5 interneuron (Mus)"
-### C-C motif chemokine 3 proteolytic cleavage product `http://purl.obolibrary.org/obo/PR_000018732`
+### L5/6 cck cortical GABAergic interneuron (Mmus) `http://purl.obolibrary.org/obo/CL_4023071`
#### Added
-- [C-C motif chemokine 3 proteolytic cleavage product](http://purl.obolibrary.org/obo/PR_000018732) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "Category=modification."
+- [L5/6 cck cortical GABAergic interneuron (Mmus)](http://purl.obolibrary.org/obo/CL_4023071) [symbol](http://purl.obolibrary.org/obo/IAO_0000028) "L5/6 cck interneuron (Mus)"
-- [C-C motif chemokine 3 proteolytic cleavage product](http://purl.obolibrary.org/obo/PR_000018732) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "CCL3/ClvPrd"
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [PRO-short-label](http://purl.obolibrary.org/obo/pr#PRO-short-label)
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PRO:DNx"
+### L5/6 near-projecting glutamatergic neuron of the primary motor cortex `http://purl.obolibrary.org/obo/CL_4023043`
-- [C-C motif chemokine 3 proteolytic cleavage product](http://purl.obolibrary.org/obo/PR_000018732) [label](http://www.w3.org/2000/01/rdf-schema#label) "C-C motif chemokine 3 proteolytic cleavage product"
-
-- [C-C motif chemokine 3 proteolytic cleavage product](http://purl.obolibrary.org/obo/PR_000018732) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "protein"
+#### Added
+- [L5/6 near-projecting glutamatergic neuron of the primary motor cortex](http://purl.obolibrary.org/obo/CL_4023043) [symbol](http://purl.obolibrary.org/obo/IAO_0000028) "L5/6 NP glut MOp"
-- [C-C motif chemokine 3 proteolytic cleavage product](http://purl.obolibrary.org/obo/PR_000018732) [id](http://www.geneontology.org/formats/oboInOwl#id) "PR:000018732"
-- [C-C motif chemokine 3 proteolytic cleavage product](http://purl.obolibrary.org/obo/PR_000018732) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A C-C motif chemokine 3 that has been processed by proteolytic cleavage."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PRO:DNx"
+### L5/6 non-Martinotti sst GABAergic cortical interneuron (Mmus) `http://purl.obolibrary.org/obo/CL_4023118`
-- Class: [C-C motif chemokine 3 proteolytic cleavage product](http://purl.obolibrary.org/obo/PR_000018732)
+#### Added
+- [L5/6 non-Martinotti sst GABAergic cortical interneuron (Mmus)](http://purl.obolibrary.org/obo/CL_4023118) [symbol](http://purl.obolibrary.org/obo/IAO_0000028) "L5/6 non-Martinotti sst interneuron (Mus)"
-- [C-C motif chemokine 3 proteolytic cleavage product](http://purl.obolibrary.org/obo/PR_000018732) EquivalentTo [C-C motif chemokine 3](http://purl.obolibrary.org/obo/PR_000002123) and ([output of](http://purl.obolibrary.org/obo/RO_0002353) some [protein processing](http://purl.obolibrary.org/obo/GO_0016485))
-- [C-C motif chemokine 3 proteolytic cleavage product](http://purl.obolibrary.org/obo/PR_000018732) SubClassOf [C-C motif chemokine 3](http://purl.obolibrary.org/obo/PR_000002123)
+### L6 corticothalamic-projecting glutamatergic cortical neuron `http://purl.obolibrary.org/obo/CL_4023042`
-- [C-C motif chemokine 3 proteolytic cleavage product](http://purl.obolibrary.org/obo/PR_000018732) SubClassOf [proteolytic cleavage product](http://purl.obolibrary.org/obo/PR_000018264)
+#### Added
+- [L6 corticothalamic-projecting glutamatergic cortical neuron](http://purl.obolibrary.org/obo/CL_4023042) [symbol](http://purl.obolibrary.org/obo/IAO_0000028) "L6 CT glut"
-### C-C motif chemokine 3/4 `http://purl.obolibrary.org/obo/PR_000001998`
+### L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex `http://purl.obolibrary.org/obo/CL_4023050`
#### Added
-- [C-C motif chemokine 3/4](http://purl.obolibrary.org/obo/PR_000001998) [label](http://www.w3.org/2000/01/rdf-schema#label) "C-C motif chemokine 3/4"
+- [L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex](http://purl.obolibrary.org/obo/CL_4023050) [symbol](http://purl.obolibrary.org/obo/IAO_0000028) "L6 IT glut MOp"
-- [C-C motif chemokine 3/4](http://purl.obolibrary.org/obo/PR_000001998) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "protein"
-- [C-C motif chemokine 3/4](http://purl.obolibrary.org/obo/PR_000001998) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A C/C-C motif small inducible chemokine that is a translation product of the CCL3, CCL3L1/CCL3L3, or CCL4 gene."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PRO:WCB"
+### L6 tyrosine hydroxylase sst GABAergic cortical interneuron (Mmus) `http://purl.obolibrary.org/obo/CL_4023075`
-- [C-C motif chemokine 3/4](http://purl.obolibrary.org/obo/PR_000001998) [id](http://www.geneontology.org/formats/oboInOwl#id) "PR:000001998"
-
-- [C-C motif chemokine 3/4](http://purl.obolibrary.org/obo/PR_000001998) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PIRSF:PIRSF500569"
+#### Added
+- [L6 tyrosine hydroxylase sst GABAergic cortical interneuron (Mmus)](http://purl.obolibrary.org/obo/CL_4023075) [symbol](http://purl.obolibrary.org/obo/IAO_0000028) "L6 th sst interneuron (Mus)"
-- [C-C motif chemokine 3/4](http://purl.obolibrary.org/obo/PR_000001998) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "Category=family."
-- Class: [C-C motif chemokine 3/4](http://purl.obolibrary.org/obo/PR_000001998)
+### L6b glutamatergic cortical neuron `http://purl.obolibrary.org/obo/CL_4023038`
-- [C-C motif chemokine 3/4](http://purl.obolibrary.org/obo/PR_000001998) SubClassOf [C/C-C motif small inducible chemokine](http://purl.obolibrary.org/obo/PR_000001808)
+#### Added
+- [L6b glutamatergic cortical neuron](http://purl.obolibrary.org/obo/CL_4023038) [symbol](http://purl.obolibrary.org/obo/IAO_0000028) "L6b glut"
-### C/C-C motif small inducible chemokine `http://purl.obolibrary.org/obo/PR_000001808`
+### L6b subplate glutamatergic neuron of the primary motor cortex `http://purl.obolibrary.org/obo/CL_4023046`
#### Added
-- [C/C-C motif small inducible chemokine](http://purl.obolibrary.org/obo/PR_000001808) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "fam:C/C-C chemokine"
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [PRO-short-label](http://purl.obolibrary.org/obo/pr#PRO-short-label)
-
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PRO:DAN"
+- [L6b subplate glutamatergic neuron of the primary motor cortex](http://purl.obolibrary.org/obo/CL_4023046) [symbol](http://purl.obolibrary.org/obo/IAO_0000028) "L6b subplate glut"
-- [C/C-C motif small inducible chemokine](http://purl.obolibrary.org/obo/PR_000001808) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A protein with core architecture consisting of a Small cytokines (intecrine/chemokine), interleukin-8 like (Pfam:PF00048) domain."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PRO:WCB"
-- [C/C-C motif small inducible chemokine](http://purl.obolibrary.org/obo/PR_000001808) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PIRSF:PIRSF001950"
+### Leydig cell `http://purl.obolibrary.org/obo/CL_0000178`
+#### Removed
+- [Leydig cell](http://purl.obolibrary.org/obo/CL_0000178) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [C/C-C motif small inducible chemokine](http://purl.obolibrary.org/obo/PR_000001808) [id](http://www.geneontology.org/formats/oboInOwl#id) "PR:000001808"
-- [C/C-C motif small inducible chemokine](http://purl.obolibrary.org/obo/PR_000001808) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "Category=family."
-- [C/C-C motif small inducible chemokine](http://purl.obolibrary.org/obo/PR_000001808) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "protein"
+### Leydig cell region of testis `http://purl.obolibrary.org/obo/UBERON_0005212`
+#### Removed
+- [Leydig cell region of testis](http://purl.obolibrary.org/obo/UBERON_0005212) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [C/C-C motif small inducible chemokine](http://purl.obolibrary.org/obo/PR_000001808) [label](http://www.w3.org/2000/01/rdf-schema#label) "C/C-C motif small inducible chemokine"
-- Class: [C/C-C motif small inducible chemokine](http://purl.obolibrary.org/obo/PR_000001808)
-- [C/C-C motif small inducible chemokine](http://purl.obolibrary.org/obo/PR_000001808) SubClassOf [CHEBI_36080](http://purl.obolibrary.org/obo/CHEBI_36080)
+### Ly-76 high positive erythrocyte `http://purl.obolibrary.org/obo/CL_0002022`
+#### Removed
+- [Ly-76 high positive erythrocyte](http://purl.obolibrary.org/obo/CL_0002022) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-- [C/C-C motif small inducible chemokine](http://purl.obolibrary.org/obo/PR_000001808) SubClassOf [protein](http://purl.obolibrary.org/obo/PR_000000001)
-### CCL3-positive alveolar macrophage `http://purl.obolibrary.org/obo/CL_4033041`
+### Mueller cell `http://purl.obolibrary.org/obo/CL_0000636`
#### Added
-- [CCL3-positive alveolar macrophage](http://purl.obolibrary.org/obo/CL_4033041) [contributor](http://purl.org/dc/terms/contributor) [0000-0001-6677-8489](https://orcid.org/0000-0001-6677-8489)
+- [Mueller cell](http://purl.obolibrary.org/obo/CL_0000636) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "Muller cell"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.21769/BioProtoc.4179"
+
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [a mis-spelling that is in common use and thus recorded](http://purl.obolibrary.org/obo/uberon/core#MISSPELLING)
-- [CCL3-positive alveolar macrophage](http://purl.obolibrary.org/obo/CL_4033041) [contributor](http://purl.org/dc/terms/contributor) [0000-0002-9185-3994](https://orcid.org/0000-0002-9185-3994)
-- [CCL3-positive alveolar macrophage](http://purl.obolibrary.org/obo/CL_4033041) [label](http://www.w3.org/2000/01/rdf-schema#label) "CCL3-positive alveolar macrophage"
+### NK1.1-positive natural killer cell, mouse `http://purl.obolibrary.org/obo/CL_0002438`
+#### Removed
+- [NK1.1-positive natural killer cell, mouse](http://purl.obolibrary.org/obo/CL_0002438) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
+
-- [CCL3-positive alveolar macrophage](http://purl.obolibrary.org/obo/CL_4033041) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "An alveolar macrophage that expresses CCL3."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:37291214"
-- [CCL3-positive alveolar macrophage](http://purl.obolibrary.org/obo/CL_4033041) [date](http://purl.org/dc/terms/date) "2023-06-15T12:53:08Z"^^[dateTime](http://www.w3.org/2001/XMLSchema#dateTime)
+### NKG2-A/NKG2-B type II integral membrane protein `http://purl.obolibrary.org/obo/PR_000002023`
-- [CCL3-positive alveolar macrophage](http://purl.obolibrary.org/obo/CL_4033041) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "alveolar macrophage CCL3-positive"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:37291214"
+#### Added
+- [NKG2-A/NKG2-B type II integral membrane protein](http://purl.obolibrary.org/obo/PR_000002023) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [NKG2-A/NKG2-B type II integral membrane protein (human)](http://purl.obolibrary.org/obo/PR_P26715)
-- Class: [CCL3-positive alveolar macrophage](http://purl.obolibrary.org/obo/CL_4033041)
-- [CCL3-positive alveolar macrophage](http://purl.obolibrary.org/obo/CL_4033041) SubClassOf [alveolar macrophage](http://purl.obolibrary.org/obo/CL_0000583)
+### OMO_0001000 `http://purl.obolibrary.org/obo/OMO_0001000`
-- [CCL3-positive alveolar macrophage](http://purl.obolibrary.org/obo/CL_4033041) SubClassOf [expresses](http://purl.obolibrary.org/obo/RO_0002292) some [C-C motif chemokine 3](http://purl.obolibrary.org/obo/PR_000002123)
+#### Added
+- Individual: [OMO_0001000](http://purl.obolibrary.org/obo/OMO_0001000)
-### CD8_alpha-negative CD11b-negative dendritic cell `http://purl.obolibrary.org/obo/CL_0000998`
+### ON-bipolar cell `http://purl.obolibrary.org/obo/CL_0000749`
#### Removed
-- [CD8_alpha-negative CD11b-negative dendritic cell](http://purl.obolibrary.org/obo/CL_0000998) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "CD8_alpha-negative CD11b-negative dendritic cell is a conventional dendritic cell that is CD11b-negative, CD4-negative CD8_alpha-negative and is CD205-positive. This cell is able to cross- present antigen to CD8-alpha-positive T cells."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMCID:PMC2346585"
+- [ON-bipolar cell](http://purl.obolibrary.org/obo/CL_0000749) SubClassOf [has soma location](http://purl.obolibrary.org/obo/RO_0002100) some [inner nuclear layer of retina](http://purl.obolibrary.org/obo/UBERON_0001791)
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "http:www.immgen.org/index_content.html"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GO_REF:0000031"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:amm"
+### Purkinje cell layer of cerebellar cortex `http://purl.obolibrary.org/obo/UBERON_0002979`
+#### Removed
+- [Purkinje cell layer of cerebellar cortex](http://purl.obolibrary.org/obo/UBERON_0002979) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-#### Added
-- [CD8_alpha-negative CD11b-negative dendritic cell](http://purl.obolibrary.org/obo/CL_0000998) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "CD8_alpha-negative CD11b-negative dendritic cell is a conventional dendritic cell that is CD11b-negative, CD4-negative CD8_alpha-negative and is CD205-positive. This cell is able to cross- present antigen to CD8-alpha-positive T cells."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMCID:PMC2346585"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "http://www.immgen.org/index_content.html"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GO_REF:0000031"
+### S-shaped body `http://purl.obolibrary.org/obo/UBERON_0004199`
+#### Removed
+- [S-shaped body](http://purl.obolibrary.org/obo/UBERON_0004199) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:amm"
-### CHEBI_15378 `http://purl.obolibrary.org/obo/CHEBI_15378`
+### SCO-spondin `http://purl.obolibrary.org/obo/PR_000015658`
#### Added
-- Class: [CHEBI_15378](http://purl.obolibrary.org/obo/CHEBI_15378)
+- [SCO-spondin](http://purl.obolibrary.org/obo/PR_000015658) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [SCO-spondin (human)](http://purl.obolibrary.org/obo/PR_A2VEC9)
-### CHEBI_29999 `http://purl.obolibrary.org/obo/CHEBI_29999`
+### SLAM family member 5 `http://purl.obolibrary.org/obo/PR_000001319`
#### Added
-- Class: [CHEBI_29999](http://purl.obolibrary.org/obo/CHEBI_29999)
+- [SLAM family member 5](http://purl.obolibrary.org/obo/PR_000001319) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [SLAM family member 5 (human)](http://purl.obolibrary.org/obo/PR_Q9UIB8)
-### CHEBI_30616 `http://purl.obolibrary.org/obo/CHEBI_30616`
+### T-box transcription factor TBX21 `http://purl.obolibrary.org/obo/PR_000001835`
#### Added
-- Class: [CHEBI_30616](http://purl.obolibrary.org/obo/CHEBI_30616)
+- [T-box transcription factor TBX21](http://purl.obolibrary.org/obo/PR_000001835) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [T-box transcription factor TBX21 (human)](http://purl.obolibrary.org/obo/PR_Q9UL17)
-### CHEBI_43474 `http://purl.obolibrary.org/obo/CHEBI_43474`
+### T-cell acute lymphocytic leukemia protein 1 `http://purl.obolibrary.org/obo/PR_000016043`
#### Added
-- Class: [CHEBI_43474](http://purl.obolibrary.org/obo/CHEBI_43474)
+- [T-cell acute lymphocytic leukemia protein 1](http://purl.obolibrary.org/obo/PR_000016043) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [T-cell acute lymphocytic leukemia protein 1 (human)](http://purl.obolibrary.org/obo/PR_P17542)
-### CHEBI_456216 `http://purl.obolibrary.org/obo/CHEBI_456216`
+### T-cell surface glycoprotein CD1a `http://purl.obolibrary.org/obo/PR_000002025`
#### Added
-- Class: [CHEBI_456216](http://purl.obolibrary.org/obo/CHEBI_456216)
+- [T-cell surface glycoprotein CD1a](http://purl.obolibrary.org/obo/PR_000002025) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [T-cell surface glycoprotein CD1a (human)](http://purl.obolibrary.org/obo/PR_P06126)
-### CHEBI_46858 `http://purl.obolibrary.org/obo/CHEBI_46858`
+### T-cell surface glycoprotein CD1c `http://purl.obolibrary.org/obo/PR_000002027`
#### Added
-- Class: [CHEBI_46858](http://purl.obolibrary.org/obo/CHEBI_46858)
+- [T-cell surface glycoprotein CD1c](http://purl.obolibrary.org/obo/PR_000002027) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [T-cell surface glycoprotein CD1c (human)](http://purl.obolibrary.org/obo/PR_P29017)
-### CHEBI_57930 `http://purl.obolibrary.org/obo/CHEBI_57930`
+### T-cell surface glycoprotein CD5 `http://purl.obolibrary.org/obo/PR_000001839`
#### Added
-- Class: [CHEBI_57930](http://purl.obolibrary.org/obo/CHEBI_57930)
+- [T-cell surface glycoprotein CD5](http://purl.obolibrary.org/obo/PR_000001839) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [T-cell surface glycoprotein CD5 (human)](http://purl.obolibrary.org/obo/PR_P06127)
-### CHEBI_61557 `http://purl.obolibrary.org/obo/CHEBI_61557`
+### T-cell surface glycoprotein CD8 alpha chain `http://purl.obolibrary.org/obo/PR_000001084`
#### Added
-- Class: [CHEBI_61557](http://purl.obolibrary.org/obo/CHEBI_61557)
+- [T-cell surface glycoprotein CD8 alpha chain](http://purl.obolibrary.org/obo/PR_000001084) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [T-cell surface glycoprotein CD8 alpha chain (human)](http://purl.obolibrary.org/obo/PR_P01732)
-### CHEBI_82620 `http://purl.obolibrary.org/obo/CHEBI_82620`
+### T-cell surface glycoprotein CD8 alpha chain isoform 1 `http://purl.obolibrary.org/obo/PR_000025403`
#### Added
-- Class: [CHEBI_82620](http://purl.obolibrary.org/obo/CHEBI_82620)
+- [T-cell surface glycoprotein CD8 alpha chain isoform 1](http://purl.obolibrary.org/obo/PR_000025403) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [T-cell surface glycoprotein CD8 alpha chain isoform 1 (human)](http://purl.obolibrary.org/obo/PR_P01732-1)
-### CHEBI_83421 `http://purl.obolibrary.org/obo/CHEBI_83421`
+### T-cell surface glycoprotein CD8 beta chain `http://purl.obolibrary.org/obo/PR_000001085`
#### Added
-- Class: [CHEBI_83421](http://purl.obolibrary.org/obo/CHEBI_83421)
+- [T-cell surface glycoprotein CD8 beta chain](http://purl.obolibrary.org/obo/PR_000001085) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [T-cell surface glycoprotein CD8 beta chain (human)](http://purl.obolibrary.org/obo/PR_P10966)
-### D1/D2-hybrid medium spiny neuron `http://purl.obolibrary.org/obo/CL_4030050`
+### T-cell-specific surface glycoprotein CD28 `http://purl.obolibrary.org/obo/PR_000001841`
#### Added
-- [D1/D2-hybrid medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030050) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "D1/D2-hybrid MSN"
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
+- [T-cell-specific surface glycoprotein CD28](http://purl.obolibrary.org/obo/PR_000001841) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [T-cell-specific surface glycoprotein CD28 (human)](http://purl.obolibrary.org/obo/PR_P10747)
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) [j.cub.2021.10.015](DOI:10.1016/j.cub.2021.10.015)
-- [D1/D2-hybrid medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030050) [label](http://www.w3.org/2000/01/rdf-schema#label) "D1/D2-hybrid medium spiny neuron"
+### Thy-1 membrane glycoprotein `http://purl.obolibrary.org/obo/PR_000001843`
-- [D1/D2-hybrid medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030050) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A medium spiny neuron that expresses both DRD1 and DRD2 and is part of an extra-striosomal part of dorsal striatum."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) [j.cub.2021.10.015](DOI:10.1016/j.cub.2021.10.015)
-
-- [D1/D2-hybrid medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030050) [date](http://purl.org/dc/terms/date) "2023-06-02T15:19:45Z"^^[dateTime](http://www.w3.org/2001/XMLSchema#dateTime)
+#### Added
+- [Thy-1 membrane glycoprotein](http://purl.obolibrary.org/obo/PR_000001843) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [Thy-1 membrane glycoprotein (human)](http://purl.obolibrary.org/obo/PR_P04216)
-- [D1/D2-hybrid medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030050) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "D1/2"
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) [j.cub.2021.10.015](DOI:10.1016/j.cub.2021.10.015)
+### UBPROP_0000111 `http://purl.obolibrary.org/obo/UBPROP_0000111`
-- [D1/D2-hybrid medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030050) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "D1/D2 hybrid"
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
+#### Added
+- AnnotationProperty: [UBPROP_0000111](http://purl.obolibrary.org/obo/UBPROP_0000111)
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) [j.cub.2021.10.015](DOI:10.1016/j.cub.2021.10.015)
-- [D1/D2-hybrid medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030050) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "It has been noted in non-human primate species that the D1/D2-hybrid medium spiny neuron (D1/2) cell type shows the same amount of DRD1 expression as nearby D1 medium spiny neurons but far less DRD2 expression compared to nearby D2 medium spiny neurons. In Rhesus macaques, RXFP1 has been noted as a highly specific marker gene for the D1/2 cell type. The D1/2 cell type has also been described as having characteristics similar to a novel medium spiny neuron described in rodents (D1H or eccentric spiny projection neuron). Although an extrastriosomal cell type, the D1/2 cell type had been noted to express many of the genes associated with striosome, suggesting a possible homology to ‘‘exo-patch’’ cells."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) [j.cub.2021.10.015](DOI:10.1016/j.cub.2021.10.015)
+### V(D)J recombination-activating protein 1 `http://purl.obolibrary.org/obo/PR_000003457`
-- [D1/D2-hybrid medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030050) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "hybrid D1/2 cell type"
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
+#### Added
+- [V(D)J recombination-activating protein 1](http://purl.obolibrary.org/obo/PR_000003457) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [V(D)J recombination-activating protein 1 (human)](http://purl.obolibrary.org/obo/PR_P15918)
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) [j.cub.2021.10.015](DOI:10.1016/j.cub.2021.10.015)
-- Class: [D1/D2-hybrid medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030050)
+### V(D)J recombination-activating protein 2 `http://purl.obolibrary.org/obo/PR_000003460`
-- [D1/D2-hybrid medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030050) SubClassOf [has soma location](http://purl.obolibrary.org/obo/RO_0002100) some [dorsal striatum](http://purl.obolibrary.org/obo/UBERON_0005382)
+#### Added
+- [V(D)J recombination-activating protein 2](http://purl.obolibrary.org/obo/PR_000003460) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [V(D)J recombination-activating protein 2 (human)](http://purl.obolibrary.org/obo/PR_P55895)
-- [D1/D2-hybrid medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030050) SubClassOf [expresses](http://purl.obolibrary.org/obo/RO_0002292) some [D(1A) dopamine receptor](http://purl.obolibrary.org/obo/PR_000001175)
-- [D1/D2-hybrid medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030050) SubClassOf [expresses](http://purl.obolibrary.org/obo/RO_0002292) some [D(2) dopamine receptor](http://purl.obolibrary.org/obo/PR_000001177)
+### VIP peptides `http://purl.obolibrary.org/obo/PR_000017299`
-- [D1/D2-hybrid medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030050) SubClassOf [medium spiny neuron](http://purl.obolibrary.org/obo/CL_1001474)
+#### Added
+- [VIP peptides](http://purl.obolibrary.org/obo/PR_000017299) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [VIP peptides (human)](http://purl.obolibrary.org/obo/PR_P01282)
-### G protein-coupled ADP receptor activity `http://purl.obolibrary.org/obo/GO_0001621`
+### a mis-spelling that is in common use and thus recorded `http://purl.obolibrary.org/obo/uberon/core#MISSPELLING`
#### Added
-- [G protein-coupled ADP receptor activity](http://purl.obolibrary.org/obo/GO_0001621) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "molecular_function"
-
-- [G protein-coupled ADP receptor activity](http://purl.obolibrary.org/obo/GO_0001621) [has_alternative_id](http://www.geneontology.org/formats/oboInOwl#hasAlternativeId) "GO:0045032"
+- [a mis-spelling that is in common use and thus recorded](http://purl.obolibrary.org/obo/uberon/core#MISSPELLING) [label](http://www.w3.org/2000/01/rdf-schema#label) "a mis-spelling that is in common use and thus recorded"
-- [G protein-coupled ADP receptor activity](http://purl.obolibrary.org/obo/GO_0001621) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "platelet ADP receptor activity"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:mah"
-- [G protein-coupled ADP receptor activity](http://purl.obolibrary.org/obo/GO_0001621) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0001621"
+### acropodial skeleton `http://purl.obolibrary.org/obo/UBERON_0010543`
+#### Removed
+- [acropodial skeleton](http://purl.obolibrary.org/obo/UBERON_0010543) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000)
-- [G protein-coupled ADP receptor activity](http://purl.obolibrary.org/obo/GO_0001621) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Combining with ADP and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:mah"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:signaling"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:11196645"
+### acropodium region `http://purl.obolibrary.org/obo/UBERON_0012354`
+#### Removed
+- [acropodium region](http://purl.obolibrary.org/obo/UBERON_0012354) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000)
-- [G protein-coupled ADP receptor activity](http://purl.obolibrary.org/obo/GO_0001621) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "ADP-activated nucleotide receptor activity"
-- [G protein-coupled ADP receptor activity](http://purl.obolibrary.org/obo/GO_0001621) [label](http://www.w3.org/2000/01/rdf-schema#label) "G protein-coupled ADP receptor activity"
-- [G protein-coupled ADP receptor activity](http://purl.obolibrary.org/obo/GO_0001621) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "K101 receptor"
+### acts on population of `http://purl.obolibrary.org/obo/RO_0012003`
+#### Removed
+- [acts on population of](http://purl.obolibrary.org/obo/RO_0012003) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "pg"
-- [G protein-coupled ADP receptor activity](http://purl.obolibrary.org/obo/GO_0001621) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "ADP receptor activity"
+#### Added
+- [acts on population of](http://purl.obolibrary.org/obo/RO_0012003) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) [0000-0003-1813-6857](https://orcid.org/0000-0003-1813-6857)
-- [G protein-coupled ADP receptor activity](http://purl.obolibrary.org/obo/GO_0001621) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "ADP-activated adenosine receptor activity"
-- Class: [G protein-coupled ADP receptor activity](http://purl.obolibrary.org/obo/GO_0001621)
+### acts upstream of or within `http://purl.obolibrary.org/obo/RO_0002264`
+#### Removed
+- [acts upstream of or within](http://purl.obolibrary.org/obo/RO_0002264) [see also](http://www.w3.org/2000/01/rdf-schema#seeAlso) [Acts_upstream_of_or_within](http://wiki.geneontology.org/index.php/Acts_upstream_of_or_within)
-- [G protein-coupled ADP receptor activity](http://purl.obolibrary.org/obo/GO_0001621) EquivalentTo [G protein-coupled receptor activity](http://purl.obolibrary.org/obo/GO_0004930) and ([has input](http://purl.obolibrary.org/obo/RO_0002233) some [CHEBI_456216](http://purl.obolibrary.org/obo/CHEBI_456216))
+#### Added
+- [acts upstream of or within](http://purl.obolibrary.org/obo/RO_0002264) [see also](http://www.w3.org/2000/01/rdf-schema#seeAlso) "https://wiki.geneontology.org/Acts_upstream_of_or_within"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI)
-- [G protein-coupled ADP receptor activity](http://purl.obolibrary.org/obo/GO_0001621) SubClassOf [has part](http://purl.obolibrary.org/obo/BFO_0000051) some [ADP binding](http://purl.obolibrary.org/obo/GO_0043531)
-- [G protein-coupled ADP receptor activity](http://purl.obolibrary.org/obo/GO_0001621) SubClassOf [G protein-coupled receptor activity](http://purl.obolibrary.org/obo/GO_0004930)
+### acts upstream of or within, negative effect `http://purl.obolibrary.org/obo/RO_0004033`
-- [G protein-coupled ADP receptor activity](http://purl.obolibrary.org/obo/GO_0001621) SubClassOf [has input](http://purl.obolibrary.org/obo/RO_0002233) some [CHEBI_456216](http://purl.obolibrary.org/obo/CHEBI_456216)
+#### Added
+- [acts upstream of or within, negative effect](http://purl.obolibrary.org/obo/RO_0004033) [see also](http://www.w3.org/2000/01/rdf-schema#seeAlso) "https://wiki.geneontology.org/Acts_upstream_of_or_within,_negative_effect"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI)
-### G protein-coupled ATP receptor activity `http://purl.obolibrary.org/obo/GO_0045031`
+### acts upstream of or within, positive effect `http://purl.obolibrary.org/obo/RO_0004032`
+#### Removed
+- [acts upstream of or within, positive effect](http://purl.obolibrary.org/obo/RO_0004032) [see also](http://www.w3.org/2000/01/rdf-schema#seeAlso) [_positive_effect](http://wiki.geneontology.org/index.php/Acts_upstream_of_or_within,_positive_effect)
#### Added
-- [G protein-coupled ATP receptor activity](http://purl.obolibrary.org/obo/GO_0045031) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "molecular_function"
+- [acts upstream of or within, positive effect](http://purl.obolibrary.org/obo/RO_0004032) [see also](http://www.w3.org/2000/01/rdf-schema#seeAlso) "https://wiki.geneontology.org/Acts_upstream_of_or_within,_positive_effect"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI)
-- [G protein-coupled ATP receptor activity](http://purl.obolibrary.org/obo/GO_0045031) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0045031"
-- [G protein-coupled ATP receptor activity](http://purl.obolibrary.org/obo/GO_0045031) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Combining with ATP and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:mah"
+### acts upstream of, negative effect `http://purl.obolibrary.org/obo/RO_0004035`
+#### Removed
+- [acts upstream of, negative effect](http://purl.obolibrary.org/obo/RO_0004035) [see also](http://www.w3.org/2000/01/rdf-schema#seeAlso) [_negative_effect](http://wiki.geneontology.org/index.php/Acts_upstream_of,_negative_effect)
-- [G protein-coupled ATP receptor activity](http://purl.obolibrary.org/obo/GO_0045031) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "ATP-activated adenosine receptor activity"
+#### Added
+- [acts upstream of, negative effect](http://purl.obolibrary.org/obo/RO_0004035) [see also](http://www.w3.org/2000/01/rdf-schema#seeAlso) "https://wiki.geneontology.org/Acts_upstream_of,_negative_effect"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI)
-- [G protein-coupled ATP receptor activity](http://purl.obolibrary.org/obo/GO_0045031) [label](http://www.w3.org/2000/01/rdf-schema#label) "G protein-coupled ATP receptor activity"
-- [G protein-coupled ATP receptor activity](http://purl.obolibrary.org/obo/GO_0045031) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "ATP-activated nucleotide receptor activity"
+### acts upstream of, positive effect `http://purl.obolibrary.org/obo/RO_0004034`
+#### Removed
+- [acts upstream of, positive effect](http://purl.obolibrary.org/obo/RO_0004034) [see also](http://www.w3.org/2000/01/rdf-schema#seeAlso) [_positive_effect](http://wiki.geneontology.org/index.php/Acts_upstream_of,_positive_effect)
-- Class: [G protein-coupled ATP receptor activity](http://purl.obolibrary.org/obo/GO_0045031)
+#### Added
+- [acts upstream of, positive effect](http://purl.obolibrary.org/obo/RO_0004034) [see also](http://www.w3.org/2000/01/rdf-schema#seeAlso) "https://wiki.geneontology.org/Acts_upstream_of,_positive_effect"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI)
-- [G protein-coupled ATP receptor activity](http://purl.obolibrary.org/obo/GO_0045031) EquivalentTo [G protein-coupled receptor activity](http://purl.obolibrary.org/obo/GO_0004930) and ([has input](http://purl.obolibrary.org/obo/RO_0002233) some [CHEBI_30616](http://purl.obolibrary.org/obo/CHEBI_30616))
-- [G protein-coupled ATP receptor activity](http://purl.obolibrary.org/obo/GO_0045031) SubClassOf [has input](http://purl.obolibrary.org/obo/RO_0002233) some [CHEBI_30616](http://purl.obolibrary.org/obo/CHEBI_30616)
+### adenohypophyseal placode `http://purl.obolibrary.org/obo/UBERON_0009122`
+#### Removed
+- [adenohypophyseal placode](http://purl.obolibrary.org/obo/UBERON_0009122) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [G protein-coupled ATP receptor activity](http://purl.obolibrary.org/obo/GO_0045031) SubClassOf [G protein-coupled receptor activity](http://purl.obolibrary.org/obo/GO_0004930)
-### GCIs
+### adhesion G protein-coupled receptor E1 `http://purl.obolibrary.org/obo/PR_000001813`
#### Added
-- [island of Calleja](http://purl.obolibrary.org/obo/UBERON_0001881) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [Rodentia](http://purl.obolibrary.org/obo/NCBITaxon_9989)) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [olfactory tubercle](http://purl.obolibrary.org/obo/UBERON_0001883)
- - [source](http://www.geneontology.org/formats/oboInOwl#source) "MP"
-
-- [island of Calleja](http://purl.obolibrary.org/obo/UBERON_0001881) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [Primates](http://purl.obolibrary.org/obo/NCBITaxon_9443)) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [nucleus accumbens](http://purl.obolibrary.org/obo/UBERON_0001882)
- - [source](http://www.geneontology.org/formats/oboInOwl#source) "MP"
+- [adhesion G protein-coupled receptor E1](http://purl.obolibrary.org/obo/PR_000001813) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [adhesion G protein-coupled receptor E1 (human)](http://purl.obolibrary.org/obo/PR_Q14246)
-### Island of Calleja granule cell `http://purl.obolibrary.org/obo/CL_4030053`
-
-#### Added
-- [Island of Calleja granule cell](http://purl.obolibrary.org/obo/CL_4030053) [date](http://purl.org/dc/terms/date) "2023-06-14T13:37:45Z"^^[dateTime](http://www.w3.org/2001/XMLSchema#dateTime)
+### adipose macrophage `http://purl.obolibrary.org/obo/CL_0002477`
+#### Removed
+- [adipose macrophage](http://purl.obolibrary.org/obo/CL_0002477) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-- [Island of Calleja granule cell](http://purl.obolibrary.org/obo/CL_4030053) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "In Rhesus macaques, the Island of Calleja granule cell type has been noted to have enriched gene expression of CPNE4."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/j.cub.2021.10.015"
-- [Island of Calleja granule cell](http://purl.obolibrary.org/obo/CL_4030053) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "D1-ICj"
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/j.cub.2021.10.015"
+### adipose tissue `http://purl.obolibrary.org/obo/UBERON_0001013`
+#### Removed
+- [adipose tissue](http://purl.obolibrary.org/obo/UBERON_0001013) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [Island of Calleja granule cell](http://purl.obolibrary.org/obo/CL_4030053) [label](http://www.w3.org/2000/01/rdf-schema#label) "Island of Calleja granule cell"
-- [Island of Calleja granule cell](http://purl.obolibrary.org/obo/CL_4030053) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A DRD1-expressing, medium spiny neuron-like granule cell that is part of an Island of Calleja."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/j.cub.2021.10.015"
-- Class: [Island of Calleja granule cell](http://purl.obolibrary.org/obo/CL_4030053)
+### aggregate regional part of brain `http://purl.obolibrary.org/obo/UBERON_0010009`
+#### Removed
+- [aggregate regional part of brain](http://purl.obolibrary.org/obo/UBERON_0010009) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [Island of Calleja granule cell](http://purl.obolibrary.org/obo/CL_4030053) SubClassOf [granule cell](http://purl.obolibrary.org/obo/CL_0000120)
-- [Island of Calleja granule cell](http://purl.obolibrary.org/obo/CL_4030053) SubClassOf [striatum neuron](http://purl.obolibrary.org/obo/CL_0002613)
-- [Island of Calleja granule cell](http://purl.obolibrary.org/obo/CL_4030053) SubClassOf [has soma location](http://purl.obolibrary.org/obo/RO_0002100) some
-([island of Calleja](http://purl.obolibrary.org/obo/UBERON_0001881) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [ventral striatum](http://purl.obolibrary.org/obo/UBERON_0005403)))
+### allantois `http://purl.obolibrary.org/obo/UBERON_0004340`
+#### Removed
+- [allantois](http://purl.obolibrary.org/obo/UBERON_0004340) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [Island of Calleja granule cell](http://purl.obolibrary.org/obo/CL_4030053) SubClassOf [expresses](http://purl.obolibrary.org/obo/RO_0002292) some [D(1A) dopamine receptor](http://purl.obolibrary.org/obo/PR_000001175)
-### L-glutamate transmembrane transporter activity `http://purl.obolibrary.org/obo/GO_0005313`
+### alpha-(1,3)-fucosyltransferase 4 `http://purl.obolibrary.org/obo/PR_000001456`
#### Added
-- [L-glutamate transmembrane transporter activity](http://purl.obolibrary.org/obo/GO_0005313) SubClassOf [has participant](http://purl.obolibrary.org/obo/RO_0000057) some [CHEBI_29985](http://purl.obolibrary.org/obo/CHEBI_29985)
-
+- [alpha-(1,3)-fucosyltransferase 4](http://purl.obolibrary.org/obo/PR_000001456) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [alpha-(1,3)-fucosyltransferase 4 (human)](http://purl.obolibrary.org/obo/PR_P22083)
-### RXFP1-positive interface island D1-medium spiny neuron `http://purl.obolibrary.org/obo/CL_4030054`
-#### Added
-- [RXFP1-positive interface island D1-medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030054) [date](http://purl.org/dc/terms/date) "2023-06-14T14:46:08Z"^^[dateTime](http://www.w3.org/2001/XMLSchema#dateTime)
+### alpha-beta T cell `http://purl.obolibrary.org/obo/CL_0000789`
+#### Removed
+- [alpha-beta T cell](http://purl.obolibrary.org/obo/CL_0000789) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-- [RXFP1-positive interface island D1-medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030054) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "Regarding the abbreviation D1-NUDAP, NUDAP stands for "neurochemically unique domains in the accumbens and putamen". In Rhesus macaques, the RXFP1-positive interface island D1-medium spiny neuron (D1-NUDAP) has been noted to have upregulation of OPRM1 compared to DRD1-expressing medium spiny neurons located outside of the D1-exclusive island and in Islands of Calleja. Kappa-opioid receptor gene (OPRK1) has been noted to be absent from D1-NUDAP cells. Many striosome-specific markers have been noted to be upregulated in D1-NUDAP cells, including KCNIP1, KCNT1, KHDRBS3, and BACH2. PDYN, an acknowledged D1-striosome marker gene, has also been noted to be expressed in D1-NUDAPs. D1-NUDAPs also express some genes found to be selectively expressed in the matrix, including STXBP6, GDA, and SEMA3E. Gene enrichment analysis has revealed that D1-NUDAP neurons express genes that have been implicated in drug addiction and many other functions."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/j.cub.2021.10.015"
-- [RXFP1-positive interface island D1-medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030054) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "D1-NUDAP"
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/j.cub.2021.10.015"
+### alpha7 GABAergic cortical interneuron (Mmus) `http://purl.obolibrary.org/obo/CL_4023010`
-- [RXFP1-positive interface island D1-medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030054) [label](http://www.w3.org/2000/01/rdf-schema#label) "RXFP1-positive interface island D1-medium spiny neuron"
+#### Added
+- [alpha7 GABAergic cortical interneuron (Mmus)](http://purl.obolibrary.org/obo/CL_4023010) [symbol](http://purl.obolibrary.org/obo/IAO_0000028) "A7 interneuron"
-- [RXFP1-positive interface island D1-medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030054) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A DRD1-expressing medium spiny neuron that is part of dense, RXFP1-positive cell islands throughout the nucleus accumbens, putamen, and near the adjacent septal nuclei."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/j.cub.2021.10.015"
-- [RXFP1-positive interface island D1-medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030054) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "RXFP1-positive island D1-medium spiny neuron"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/j.cub.2021.10.015"
+### alveolar macrophage `http://purl.obolibrary.org/obo/CL_0000583`
+#### Removed
+- [alveolar macrophage](http://purl.obolibrary.org/obo/CL_0000583) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-- Class: [RXFP1-positive interface island D1-medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030054)
-- [RXFP1-positive interface island D1-medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030054) SubClassOf [has soma location](http://purl.obolibrary.org/obo/RO_0002100) some [ventral striatum](http://purl.obolibrary.org/obo/UBERON_0005403)
-- [RXFP1-positive interface island D1-medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030054) SubClassOf [medium spiny neuron](http://purl.obolibrary.org/obo/CL_1001474)
+### amacrine cell `http://purl.obolibrary.org/obo/CL_0000561`
+#### Removed
+- [amacrine cell](http://purl.obolibrary.org/obo/CL_0000561) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [RXFP1-positive interface island D1-medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030054) SubClassOf [expresses](http://purl.obolibrary.org/obo/RO_0002292) some [relaxin receptor 1](http://purl.obolibrary.org/obo/PR_000001666)
+#### Added
+- [amacrine cell](http://purl.obolibrary.org/obo/CL_0000561) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "AC"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
-- [RXFP1-positive interface island D1-medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030054) SubClassOf [expresses](http://purl.obolibrary.org/obo/RO_0002292) some [D(1A) dopamine receptor](http://purl.obolibrary.org/obo/PR_000001175)
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1038/s41598-020-66092-9"
+- [amacrine cell](http://purl.obolibrary.org/obo/CL_0000561) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "ACs"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
-### T cell `http://purl.obolibrary.org/obo/CL_0000084`
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [plural term](http://purl.obolibrary.org/obo/uberon#PLURAL)
-#### Added
-- [T cell](http://purl.obolibrary.org/obo/CL_0000084) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [general_cell_types_upper_slim](http://purl.obolibrary.org/obo/cl#general_cell_types_upper_slim)
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1038/s41598-020-66092-9"
-### [tyrosine 3-monooxygenase] kinase activity `http://purl.obolibrary.org/obo/GO_0050369`
+### aminopeptidase N `http://purl.obolibrary.org/obo/PR_000002031`
#### Added
-- [[tyrosine 3-monooxygenase] kinase activity](http://purl.obolibrary.org/obo/GO_0050369) SubClassOf [has participant](http://purl.obolibrary.org/obo/RO_0000057) some [CHEBI_29999](http://purl.obolibrary.org/obo/CHEBI_29999)
-
-- [[tyrosine 3-monooxygenase] kinase activity](http://purl.obolibrary.org/obo/GO_0050369) SubClassOf [has participant](http://purl.obolibrary.org/obo/RO_0000057) some [CHEBI_456216](http://purl.obolibrary.org/obo/CHEBI_456216)
+- [aminopeptidase N](http://purl.obolibrary.org/obo/PR_000002031) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [aminopeptidase N (human)](http://purl.obolibrary.org/obo/PR_P15144)
-- [[tyrosine 3-monooxygenase] kinase activity](http://purl.obolibrary.org/obo/GO_0050369) SubClassOf [has participant](http://purl.obolibrary.org/obo/RO_0000057) some [CHEBI_15378](http://purl.obolibrary.org/obo/CHEBI_15378)
-- [[tyrosine 3-monooxygenase] kinase activity](http://purl.obolibrary.org/obo/GO_0050369) SubClassOf [has participant](http://purl.obolibrary.org/obo/RO_0000057) some [CHEBI_83421](http://purl.obolibrary.org/obo/CHEBI_83421)
+### amnion `http://purl.obolibrary.org/obo/UBERON_0000305`
+#### Removed
+- [amnion](http://purl.obolibrary.org/obo/UBERON_0000305) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [[tyrosine 3-monooxygenase] kinase activity](http://purl.obolibrary.org/obo/GO_0050369) SubClassOf [has participant](http://purl.obolibrary.org/obo/RO_0000057) some [CHEBI_30616](http://purl.obolibrary.org/obo/CHEBI_30616)
-### alveolar sac `http://purl.obolibrary.org/obo/UBERON_0002169`
+### amniotic ectoderm `http://purl.obolibrary.org/obo/UBERON_0003254`
+#### Removed
+- [amniotic ectoderm](http://purl.obolibrary.org/obo/UBERON_0003254) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-#### Added
-- [alveolar sac](http://purl.obolibrary.org/obo/UBERON_0002169) SubClassOf [has part](http://purl.obolibrary.org/obo/BFO_0000051) some [alveolus of lung](http://purl.obolibrary.org/obo/UBERON_0002299)
-### alveolus of lung `http://purl.obolibrary.org/obo/UBERON_0002299`
+### amniotic fold `http://purl.obolibrary.org/obo/UBERON_0005971`
#### Removed
-- [alveolus of lung](http://purl.obolibrary.org/obo/UBERON_0002299) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [alveolar sac](http://purl.obolibrary.org/obo/UBERON_0002169)
- - [source](http://www.geneontology.org/formats/oboInOwl#source) "FMA"
-
-#### Added
-- [alveolus of lung](http://purl.obolibrary.org/obo/UBERON_0002299) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [pulmonary acinus](http://purl.obolibrary.org/obo/UBERON_0008874)
+- [amniotic fold](http://purl.obolibrary.org/obo/UBERON_0005971) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [alveolus of lung](http://purl.obolibrary.org/obo/UBERON_0002299) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [alveolar system](http://purl.obolibrary.org/obo/UBERON_0006524)
- - [source](http://www.geneontology.org/formats/oboInOwl#source) "MA"
-### aminoacyltransferase activity `http://purl.obolibrary.org/obo/GO_0016755`
+### amygdala excitatory neuron `http://purl.obolibrary.org/obo/CL_4023039`
#### Removed
-- [aminoacyltransferase activity](http://purl.obolibrary.org/obo/GO_0016755) SubClassOf [catalytic activity, acting on a protein](http://purl.obolibrary.org/obo/GO_0140096)
+- [amygdala excitatory neuron](http://purl.obolibrary.org/obo/CL_4023039) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+### amygdala pyramidal neuron `http://purl.obolibrary.org/obo/CL_4023110`
+#### Removed
+- [amygdala pyramidal neuron](http://purl.obolibrary.org/obo/CL_4023110) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-### ammonium transmembrane transporter activity `http://purl.obolibrary.org/obo/GO_0008519`
-#### Added
-- [ammonium transmembrane transporter activity](http://purl.obolibrary.org/obo/GO_0008519) SubClassOf [has participant](http://purl.obolibrary.org/obo/RO_0000057) some [CHEBI_28938](http://purl.obolibrary.org/obo/CHEBI_28938)
+### anal canal `http://purl.obolibrary.org/obo/UBERON_0000159`
+#### Removed
+- [anal canal](http://purl.obolibrary.org/obo/UBERON_0000159) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-### aquaporin protein `http://purl.obolibrary.org/obo/PR_000044672`
-#### Added
-- [aquaporin protein](http://purl.obolibrary.org/obo/PR_000044672) [id](http://www.geneontology.org/formats/oboInOwl#id) "PR:000044672"
-- [aquaporin protein](http://purl.obolibrary.org/obo/PR_000044672) [label](http://www.w3.org/2000/01/rdf-schema#label) "aquaporin protein"
+### anal region `http://purl.obolibrary.org/obo/UBERON_0001353`
+#### Removed
+- [anal region](http://purl.obolibrary.org/obo/UBERON_0001353) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [aquaporin protein](http://purl.obolibrary.org/obo/PR_000044672) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A channel protein that has water channel activity. A water channel enables facilitated diffusion of water (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PRO:XQ"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GO:0015250"
-- [aquaporin protein](http://purl.obolibrary.org/obo/PR_000044672) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "Category=family. Note: Aquaporin channels operate as tetramers. [PRO:DAN, IUPHARfam:119]"
+### angioblastic mesenchymal cell `http://purl.obolibrary.org/obo/CL_0000566`
+#### Removed
+- [angioblastic mesenchymal cell](http://purl.obolibrary.org/obo/CL_0000566) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-- [aquaporin protein](http://purl.obolibrary.org/obo/PR_000044672) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "water channel"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PRO:XQ"
-- [aquaporin protein](http://purl.obolibrary.org/obo/PR_000044672) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "IUPHARfam:119"
-- [aquaporin protein](http://purl.obolibrary.org/obo/PR_000044672) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "protein"
+### anorectum `http://purl.obolibrary.org/obo/UBERON_8410050`
+#### Removed
+- [anorectum](http://purl.obolibrary.org/obo/UBERON_8410050) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- Class: [aquaporin protein](http://purl.obolibrary.org/obo/PR_000044672)
-- [aquaporin protein](http://purl.obolibrary.org/obo/PR_000044672) EquivalentTo [channel protein](http://purl.obolibrary.org/obo/PR_000044676) and ([capable of](http://purl.obolibrary.org/obo/RO_0002215) some [water channel activity](http://purl.obolibrary.org/obo/GO_0015250))
-- [aquaporin protein](http://purl.obolibrary.org/obo/PR_000044672) SubClassOf [channel protein](http://purl.obolibrary.org/obo/PR_000044676)
+### anterior limiting lamina of cornea `http://purl.obolibrary.org/obo/UBERON_0004370`
+#### Removed
+- [anterior limiting lamina of cornea](http://purl.obolibrary.org/obo/UBERON_0004370) SubClassOf [connected anatomical structure](http://purl.obolibrary.org/obo/CARO_0000003)
-- [aquaporin protein](http://purl.obolibrary.org/obo/PR_000044672) SubClassOf [capable of](http://purl.obolibrary.org/obo/RO_0002215) some [water channel activity](http://purl.obolibrary.org/obo/GO_0015250)
-### basal cell of urothelium `http://purl.obolibrary.org/obo/CL_1000486`
+### anterior neural tube `http://purl.obolibrary.org/obo/UBERON_0003080`
#### Removed
-- [basal cell of urothelium](http://purl.obolibrary.org/obo/CL_1000486) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A basal cell that is part of the urothelium."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:tfm"
+- [anterior neural tube](http://purl.obolibrary.org/obo/UBERON_0003080) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [basal cell of urothelium](http://purl.obolibrary.org/obo/CL_1000486) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [urothelium](http://purl.obolibrary.org/obo/UBERON_0000365)
-#### Added
-- [basal cell of urothelium](http://purl.obolibrary.org/obo/CL_1000486) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "It has been noted in at least some mammalian species that the urothelial basal cell type is distinguished by expression of high levels of cytokeratin-5 (CK5), p63 and the signalling molecule Sonic hedgehog (Shh). Similar to intermediate cells, the urothelial basal cell type expresses CK17 but is negative for uroplakins (UPK) and CK20. Urothelial basal cells have also been noted to be smaller in diameter than urothelial intermediate cells."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1038/s41385-022-00565-0"
-- [basal cell of urothelium](http://purl.obolibrary.org/obo/CL_1000486) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "urothelial basal cell"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1111/cpr.13170"
+### anterior part of tongue `http://purl.obolibrary.org/obo/UBERON_0010032`
+#### Removed
+- [anterior part of tongue](http://purl.obolibrary.org/obo/UBERON_0010032) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1007/978-3-030-14366-4_8"
-- [basal cell of urothelium](http://purl.obolibrary.org/obo/CL_1000486) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A basal cell that is part of the urothelium. Compared to other urothelial cell types, a basal cell of the urothelium is positioned along the basement membrane, is the most undifferentiated and serves a progenitor role."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:tfm"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1038/s41385-022-00565-0"
+### anterior uvea `http://purl.obolibrary.org/obo/UBERON_0011892`
+#### Removed
+- [anterior uvea](http://purl.obolibrary.org/obo/UBERON_0011892) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-- [basal cell of urothelium](http://purl.obolibrary.org/obo/CL_1000486) SubClassOf [urothelial cell](http://purl.obolibrary.org/obo/CL_0000731)
-### bicarbonate transmembrane transporter activity `http://purl.obolibrary.org/obo/GO_0015106`
+### antigen-presenting glycoprotein CD1d `http://purl.obolibrary.org/obo/PR_000002028`
#### Added
-- [bicarbonate transmembrane transporter activity](http://purl.obolibrary.org/obo/GO_0015106) SubClassOf [has participant](http://purl.obolibrary.org/obo/RO_0000057) some [CHEBI_17544](http://purl.obolibrary.org/obo/CHEBI_17544)
+- [antigen-presenting glycoprotein CD1d](http://purl.obolibrary.org/obo/PR_000002028) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [antigen-presenting glycoprotein CD1d (human)](http://purl.obolibrary.org/obo/PR_P15813)
-### bladder urothelial cell `http://purl.obolibrary.org/obo/CL_1001428`
+### aortico-pulmonary spiral septum `http://purl.obolibrary.org/obo/UBERON_0006207`
#### Removed
-- [bladder urothelial cell](http://purl.obolibrary.org/obo/CL_1001428) SubClassOf [bladder cell](http://purl.obolibrary.org/obo/CL_1001319)
- - [is_inferred](http://www.geneontology.org/formats/oboInOwl#is_inferred) "true"
+- [aortico-pulmonary spiral septum](http://purl.obolibrary.org/obo/UBERON_0006207) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [bladder urothelial cell](http://purl.obolibrary.org/obo/CL_1001428) SubClassOf [urothelial cell](http://purl.obolibrary.org/obo/CL_0000731)
- - [is_inferred](http://www.geneontology.org/formats/oboInOwl#is_inferred) "true"
-#### Added
-- [bladder urothelial cell](http://purl.obolibrary.org/obo/CL_1001428) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "NCIT:C32210"
-- [bladder urothelial cell](http://purl.obolibrary.org/obo/CL_1001428) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "bladder transitional cell"
+### apical ectodermal ridge `http://purl.obolibrary.org/obo/UBERON_0004356`
+#### Removed
+- [apical ectodermal ridge](http://purl.obolibrary.org/obo/UBERON_0004356) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-- [bladder urothelial cell](http://purl.obolibrary.org/obo/CL_1001428) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A urothelial cell that is part of the urothelium of the urinary bladder."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1038/s41385-022-00565-0"
-- [bladder urothelial cell](http://purl.obolibrary.org/obo/CL_1001428) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "transitional epithelial cell of urinary bladder"
-- [bladder urothelial cell](http://purl.obolibrary.org/obo/CL_1001428) SubClassOf [urothelial cell](http://purl.obolibrary.org/obo/CL_0000731)
+### aponeurosis `http://purl.obolibrary.org/obo/UBERON_0006614`
+#### Removed
+- [aponeurosis](http://purl.obolibrary.org/obo/UBERON_0006614) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [bladder urothelial cell](http://purl.obolibrary.org/obo/CL_1001428) SubClassOf [bladder cell](http://purl.obolibrary.org/obo/CL_1001319)
-### blood cell `http://purl.obolibrary.org/obo/CL_0000081`
+### appendage girdle region `http://purl.obolibrary.org/obo/UBERON_0007823`
+#### Removed
+- [appendage girdle region](http://purl.obolibrary.org/obo/UBERON_0007823) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000)
-#### Added
-- [blood cell](http://purl.obolibrary.org/obo/CL_0000081) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [general_cell_types_upper_slim](http://purl.obolibrary.org/obo/cl#general_cell_types_upper_slim)
-### bone cell `http://purl.obolibrary.org/obo/CL_0001035`
+### arch of aorta `http://purl.obolibrary.org/obo/UBERON_0001508`
+#### Removed
+- [arch of aorta](http://purl.obolibrary.org/obo/UBERON_0001508) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-#### Added
-- [bone cell](http://purl.obolibrary.org/obo/CL_0001035) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [general_cell_types_upper_slim](http://purl.obolibrary.org/obo/cl#general_cell_types_upper_slim)
-### calcium ion transmembrane transporter activity `http://purl.obolibrary.org/obo/GO_0015085`
+### areolar connective tissue `http://purl.obolibrary.org/obo/UBERON_0006815`
+#### Removed
+- [areolar connective tissue](http://purl.obolibrary.org/obo/UBERON_0006815) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-#### Added
-- [calcium ion transmembrane transporter activity](http://purl.obolibrary.org/obo/GO_0015085) SubClassOf [has participant](http://purl.obolibrary.org/obo/RO_0000057) some [CHEBI_29108](http://purl.obolibrary.org/obo/CHEBI_29108)
-### cardiac muscle cell `http://purl.obolibrary.org/obo/CL_0000746`
+### arginase-1 `http://purl.obolibrary.org/obo/PR_000001844`
#### Added
-- [cardiac muscle cell](http://purl.obolibrary.org/obo/CL_0000746) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [general_cell_types_upper_slim](http://purl.obolibrary.org/obo/cl#general_cell_types_upper_slim)
+- [arginase-1](http://purl.obolibrary.org/obo/PR_000001844) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [arginase-1 (human)](http://purl.obolibrary.org/obo/PR_P05089)
-### cardiac muscle tissue `http://purl.obolibrary.org/obo/UBERON_0001133`
+### arrector muscle of hair `http://purl.obolibrary.org/obo/UBERON_0002033`
#### Removed
-- [cardiac muscle tissue](http://purl.obolibrary.org/obo/UBERON_0001133) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [heart](http://purl.obolibrary.org/obo/UBERON_0000948)
- - [source](http://www.geneontology.org/formats/oboInOwl#source) "ZFA"
+- [arrector muscle of hair](http://purl.obolibrary.org/obo/UBERON_0002033) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000)
-#### Added
-- [cardiac muscle tissue](http://purl.obolibrary.org/obo/UBERON_0001133) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [primary circulatory organ](http://purl.obolibrary.org/obo/UBERON_0007100)
-### caudate nucleus `http://purl.obolibrary.org/obo/UBERON_0001873`
+### arterial system `http://purl.obolibrary.org/obo/UBERON_0004572`
+#### Removed
+- [arterial system](http://purl.obolibrary.org/obo/UBERON_0004572) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-#### Added
-- [caudate nucleus](http://purl.obolibrary.org/obo/UBERON_0001873) [label](http://www.w3.org/2000/01/rdf-schema#label) "caudate nucleus"
-- [caudate nucleus](http://purl.obolibrary.org/obo/UBERON_0001873) [has_alternative_id](http://www.geneontology.org/formats/oboInOwl#hasAlternativeId) "UBERON:0010122"
-- [caudate nucleus](http://purl.obolibrary.org/obo/UBERON_0001873) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "EHDAA2:0004461"
+### ascending aorta `http://purl.obolibrary.org/obo/UBERON_0001496`
+#### Removed
+- [ascending aorta](http://purl.obolibrary.org/obo/UBERON_0001496) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [caudate nucleus](http://purl.obolibrary.org/obo/UBERON_0001873) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "nucleus caudatus"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Wikipedia:Caudate_nucleus"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "BTO:0000211"
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [LATIN](http://purl.obolibrary.org/obo/uberon/core#LATIN)
+### ascending colon `http://purl.obolibrary.org/obo/UBERON_0001156`
+#### Removed
+- [ascending colon](http://purl.obolibrary.org/obo/UBERON_0001156) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [caudate nucleus](http://purl.obolibrary.org/obo/UBERON_0001873) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Wikipedia:Caudate_nucleus"
-- [caudate nucleus](http://purl.obolibrary.org/obo/UBERON_0001873) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [efo_slim](http://purl.obolibrary.org/obo/uberon/core#efo_slim)
-- [caudate nucleus](http://purl.obolibrary.org/obo/UBERON_0001873) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "DHBA:10334"
+### attached to part of `http://purl.obolibrary.org/obo/RO_0002177`
+#### Removed
+- [attached to part of](http://purl.obolibrary.org/obo/RO_0002177) Domain [connected anatomical structure](http://purl.obolibrary.org/obo/CARO_0000003)
-- [caudate nucleus](http://purl.obolibrary.org/obo/UBERON_0001873) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "MA:0000894"
+- [attached to part of](http://purl.obolibrary.org/obo/RO_0002177) Range [connected anatomical structure](http://purl.obolibrary.org/obo/CARO_0000003)
-- [caudate nucleus](http://purl.obolibrary.org/obo/UBERON_0001873) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "SCTID:279297002"
+#### Added
+- [attached to part of](http://purl.obolibrary.org/obo/RO_0002177) Domain [anatomical structure](http://purl.obolibrary.org/obo/UBERON_0000061)
-- [caudate nucleus](http://purl.obolibrary.org/obo/UBERON_0001873) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "MAT:0000513"
+- [attached to part of](http://purl.obolibrary.org/obo/RO_0002177) Range [anatomical structure](http://purl.obolibrary.org/obo/UBERON_0000061)
-- [caudate nucleus](http://purl.obolibrary.org/obo/UBERON_0001873) [UBPROP_0000001](http://purl.obolibrary.org/obo/UBPROP_0000001) "Nucleus of brain which is an elongated crescent-shaped mass lying parallel and adjacent to the lateral ventricle throughout its extent[FMA:61833]."
- - [source](http://www.geneontology.org/formats/oboInOwl#source) "FMA:61833"
-- [caudate nucleus](http://purl.obolibrary.org/obo/UBERON_0001873) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "BAMS:CA"
+### auditory hillocks, pharyngeal arch 1 derived `http://purl.obolibrary.org/obo/UBERON_0016611`
+#### Removed
+- [auditory hillocks, pharyngeal arch 1 derived](http://purl.obolibrary.org/obo/UBERON_0016611) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [caudate nucleus](http://purl.obolibrary.org/obo/UBERON_0001873) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "DMBA:15855"
-- [caudate nucleus](http://purl.obolibrary.org/obo/UBERON_0001873) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "caudatum"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "BTO:0000211"
-- [caudate nucleus](http://purl.obolibrary.org/obo/UBERON_0001873) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "EFO:0000907"
+### auditory hillocks, pharyngeal arch 2 derived `http://purl.obolibrary.org/obo/UBERON_0016612`
+#### Removed
+- [auditory hillocks, pharyngeal arch 2 derived](http://purl.obolibrary.org/obo/UBERON_0016612) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [caudate nucleus](http://purl.obolibrary.org/obo/UBERON_0001873) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "uberon"
-- [caudate nucleus](http://purl.obolibrary.org/obo/UBERON_0001873) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "MESH:D002421"
-- [caudate nucleus](http://purl.obolibrary.org/obo/UBERON_0001873) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "FMA:61833"
+### auditory meatus epithelium `http://purl.obolibrary.org/obo/UBERON_0010065`
+#### Removed
+- [auditory meatus epithelium](http://purl.obolibrary.org/obo/UBERON_0010065) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [caudate nucleus](http://purl.obolibrary.org/obo/UBERON_0001873) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Subcortical nucleus of telecephalic origin consisting of an elongated gray mass lying lateral to and bordering the lateral ventricle. It is divided into a head, body and tail in some species."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "BIRNLEX:1373"
-- [caudate nucleus](http://purl.obolibrary.org/obo/UBERON_0001873) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "BAMS:Cd"
-- [caudate nucleus](http://purl.obolibrary.org/obo/UBERON_0001873) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [uberon_slim](http://purl.obolibrary.org/obo/uberon/core#uberon_slim)
+### autonomic neuron `http://purl.obolibrary.org/obo/CL_0000107`
+#### Removed
+- [autonomic neuron](http://purl.obolibrary.org/obo/CL_0000107) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [caudate nucleus](http://purl.obolibrary.org/obo/UBERON_0001873) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PBA:10082"
-- [caudate nucleus](http://purl.obolibrary.org/obo/UBERON_0001873) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "CALOHA:TS-0121"
-- [caudate nucleus](http://purl.obolibrary.org/obo/UBERON_0001873) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "Ammon horn fields"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "BAMS:CA"
+### autopod region `http://purl.obolibrary.org/obo/UBERON_0002470`
+#### Removed
+- [autopod region](http://purl.obolibrary.org/obo/UBERON_0002470) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000)
-- [caudate nucleus](http://purl.obolibrary.org/obo/UBERON_0001873) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "neuronames:226"
- - [source](http://www.geneontology.org/formats/oboInOwl#source) "BIRNLEX:1373"
-- [caudate nucleus](http://purl.obolibrary.org/obo/UBERON_0001873) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [pheno_slim](http://purl.obolibrary.org/obo/uberon/core#pheno_slim)
-- [caudate nucleus](http://purl.obolibrary.org/obo/UBERON_0001873) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "BIRNLEX:1373"
+### autopodial skeleton `http://purl.obolibrary.org/obo/UBERON_0006717`
+#### Removed
+- [autopodial skeleton](http://purl.obolibrary.org/obo/UBERON_0006717) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000)
-- [caudate nucleus](http://purl.obolibrary.org/obo/UBERON_0001873) [depicted by](http://xmlns.com/foaf/0.1/depicted_by) "http://upload.wikimedia.org/wikipedia/commons/9/91/Telencephalon-Horiconatal.jpg"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI)
-- [caudate nucleus](http://purl.obolibrary.org/obo/UBERON_0001873) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "BM:Tel-CA"
-- [caudate nucleus](http://purl.obolibrary.org/obo/UBERON_0001873) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "BTO:0000211"
+### axial mesoderm `http://purl.obolibrary.org/obo/UBERON_0003068`
+#### Removed
+- [axial mesoderm](http://purl.obolibrary.org/obo/UBERON_0003068) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [caudate nucleus](http://purl.obolibrary.org/obo/UBERON_0001873) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "caudatus"
-- [caudate nucleus](http://purl.obolibrary.org/obo/UBERON_0001873) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "HBA:4278"
-- [caudate nucleus](http://purl.obolibrary.org/obo/UBERON_0001873) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "EV:0100185"
+### axial musculature `http://purl.obolibrary.org/obo/UBERON_0013700`
+#### Removed
+- [axial musculature](http://purl.obolibrary.org/obo/UBERON_0013700) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000)
-- [caudate nucleus](http://purl.obolibrary.org/obo/UBERON_0001873) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GAID:670"
-- [caudate nucleus](http://purl.obolibrary.org/obo/UBERON_0001873) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "NCIT:C12451"
-- [caudate nucleus](http://purl.obolibrary.org/obo/UBERON_0001873) [id](http://www.geneontology.org/formats/oboInOwl#id) "UBERON:0001873"
+### axial skeletal system `http://purl.obolibrary.org/obo/UBERON_0011137`
+#### Removed
+- [axial skeletal system](http://purl.obolibrary.org/obo/UBERON_0011137) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-- [caudate nucleus](http://purl.obolibrary.org/obo/UBERON_0001873) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "EMAPA:18207"
-- [caudate nucleus](http://purl.obolibrary.org/obo/UBERON_0001873) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "UMLS:C0007461"
- - [source](http://www.geneontology.org/formats/oboInOwl#source) "BIRNLEX:1373"
- - [source](http://www.geneontology.org/formats/oboInOwl#source) "ncithesaurus:Caudate_Nucleus"
+### axial skeleton plus cranial skeleton `http://purl.obolibrary.org/obo/UBERON_0005944`
+#### Removed
+- [axial skeleton plus cranial skeleton](http://purl.obolibrary.org/obo/UBERON_0005944) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- Class: [caudate nucleus](http://purl.obolibrary.org/obo/UBERON_0001873)
-- [caudate nucleus](http://purl.obolibrary.org/obo/UBERON_0001873) SubClassOf [telencephalic nucleus](http://purl.obolibrary.org/obo/UBERON_0009663)
-- [caudate nucleus](http://purl.obolibrary.org/obo/UBERON_0001873) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [caudate-putamen](http://purl.obolibrary.org/obo/UBERON_0005383)
- - [source](http://www.geneontology.org/formats/oboInOwl#source) "MA"
+### axillary nerve `http://purl.obolibrary.org/obo/UBERON_0001493`
+#### Removed
+- [axillary nerve](http://purl.obolibrary.org/obo/UBERON_0001493) SubClassOf [neuron projection bundle](http://purl.obolibrary.org/obo/CARO_0001001)
-- [caudate nucleus](http://purl.obolibrary.org/obo/UBERON_0001873) SubClassOf [contributes to morphology of](http://purl.obolibrary.org/obo/RO_0002433) some [caudate-putamen](http://purl.obolibrary.org/obo/UBERON_0005383)
-### caudate nucleus development `http://purl.obolibrary.org/obo/GO_0021757`
+### basophil mast progenitor cell `http://purl.obolibrary.org/obo/CL_0002028`
+#### Removed
+- [basophil mast progenitor cell](http://purl.obolibrary.org/obo/CL_0002028) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-#### Added
-- [caudate nucleus development](http://purl.obolibrary.org/obo/GO_0021757) [label](http://www.w3.org/2000/01/rdf-schema#label) "caudate nucleus development"
-- [caudate nucleus development](http://purl.obolibrary.org/obo/GO_0021757) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0021757"
-- [caudate nucleus development](http://purl.obolibrary.org/obo/GO_0021757) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The progression of the caudate nucleus over time from its initial formation until its mature state. The caudate nucleus is the C-shaped structures of the striatum containing input neurons involved with control of voluntary movement in the brain."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dph"
+### basophil progenitor cell `http://purl.obolibrary.org/obo/CL_0000613`
+#### Removed
+- [basophil progenitor cell](http://purl.obolibrary.org/obo/CL_0000613) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:jid"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GO_REF:0000021"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dgh"
+### basophilic erythroblast `http://purl.obolibrary.org/obo/CL_0000549`
+#### Removed
+- [basophilic erythroblast](http://purl.obolibrary.org/obo/CL_0000549) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:cls"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ISBN:0878937420"
-- [caudate nucleus development](http://purl.obolibrary.org/obo/GO_0021757) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process"
+### bestrophin-4 `http://purl.obolibrary.org/obo/PR_000004724`
-- Class: [caudate nucleus development](http://purl.obolibrary.org/obo/GO_0021757)
+#### Added
+- [bestrophin-4](http://purl.obolibrary.org/obo/PR_000004724) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [bestrophin-4 (human)](http://purl.obolibrary.org/obo/PR_Q8NFU0)
-- [caudate nucleus development](http://purl.obolibrary.org/obo/GO_0021757) EquivalentTo [anatomical structure development](http://purl.obolibrary.org/obo/GO_0048856) and ([results in development of](http://purl.obolibrary.org/obo/RO_0002296) some [caudate nucleus](http://purl.obolibrary.org/obo/UBERON_0001873))
-- [caudate nucleus development](http://purl.obolibrary.org/obo/GO_0021757) SubClassOf [neural nucleus development](http://purl.obolibrary.org/obo/GO_0048857)
+### bilaminar disc `http://purl.obolibrary.org/obo/UBERON_0000091`
+#### Removed
+- [bilaminar disc](http://purl.obolibrary.org/obo/UBERON_0000091) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [caudate nucleus development](http://purl.obolibrary.org/obo/GO_0021757) SubClassOf [results in development of](http://purl.obolibrary.org/obo/RO_0002296) some [caudate nucleus](http://purl.obolibrary.org/obo/UBERON_0001873)
-- [caudate nucleus development](http://purl.obolibrary.org/obo/GO_0021757) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [striatum development](http://purl.obolibrary.org/obo/GO_0021756)
+### bile duct epithelium `http://purl.obolibrary.org/obo/UBERON_0004820`
+#### Removed
+- [bile duct epithelium](http://purl.obolibrary.org/obo/UBERON_0004820) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-### caudate-putamen `http://purl.obolibrary.org/obo/UBERON_0005383`
-#### Added
-- [caudate-putamen](http://purl.obolibrary.org/obo/UBERON_0005383) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [efo_slim](http://purl.obolibrary.org/obo/uberon/core#efo_slim)
-- [caudate-putamen](http://purl.obolibrary.org/obo/UBERON_0005383) [id](http://www.geneontology.org/formats/oboInOwl#id) "UBERON:0005383"
+### biliary system `http://purl.obolibrary.org/obo/UBERON_0002294`
+#### Removed
+- [biliary system](http://purl.obolibrary.org/obo/UBERON_0002294) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-- [caudate-putamen](http://purl.obolibrary.org/obo/UBERON_0005383) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "caudate putamen (striatum)"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "BAMS:CPu"
-- [caudate-putamen](http://purl.obolibrary.org/obo/UBERON_0005383) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "EMAPA:19095"
-- [caudate-putamen](http://purl.obolibrary.org/obo/UBERON_0005383) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "caudateputamen"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "NLXANAT:100312"
+### biomechanically related to `http://purl.obolibrary.org/obo/RO_0002567`
+#### Removed
+- [biomechanically related to](http://purl.obolibrary.org/obo/RO_0002567) Domain [connected anatomical structure](http://purl.obolibrary.org/obo/CARO_0000003)
-- [caudate-putamen](http://purl.obolibrary.org/obo/UBERON_0005383) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "caudate putamen"
+- [biomechanically related to](http://purl.obolibrary.org/obo/RO_0002567) Range [connected anatomical structure](http://purl.obolibrary.org/obo/CARO_0000003)
-- [caudate-putamen](http://purl.obolibrary.org/obo/UBERON_0005383) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "NLXANAT:100312"
+#### Added
+- [biomechanically related to](http://purl.obolibrary.org/obo/RO_0002567) Domain [anatomical structure](http://purl.obolibrary.org/obo/UBERON_0000061)
-- [caudate-putamen](http://purl.obolibrary.org/obo/UBERON_0005383) [editor note](http://purl.obolibrary.org/obo/IAO_0000116) "check - rodents. The caudate nucleus and putamen are separated by a clear white matter bundle in most species but not in rodents (MM)"
+- [biomechanically related to](http://purl.obolibrary.org/obo/RO_0002567) Range [anatomical structure](http://purl.obolibrary.org/obo/UBERON_0000061)
-- [caudate-putamen](http://purl.obolibrary.org/obo/UBERON_0005383) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [pheno_slim](http://purl.obolibrary.org/obo/uberon/core#pheno_slim)
-- [caudate-putamen](http://purl.obolibrary.org/obo/UBERON_0005383) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "BTO:0000212"
+### bladder lumen `http://purl.obolibrary.org/obo/UBERON_0009958`
+#### Removed
+- [bladder lumen](http://purl.obolibrary.org/obo/UBERON_0009958) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [caudate-putamen](http://purl.obolibrary.org/obo/UBERON_0005383) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "MA:0000893"
-- [caudate-putamen](http://purl.obolibrary.org/obo/UBERON_0005383) [label](http://www.w3.org/2000/01/rdf-schema#label) "caudate-putamen"
-- [caudate-putamen](http://purl.obolibrary.org/obo/UBERON_0005383) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "BAMS:CP"
+### blastocyst `http://purl.obolibrary.org/obo/UBERON_0000358`
+#### Removed
+- [blastocyst](http://purl.obolibrary.org/obo/UBERON_0000358) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [caudate-putamen](http://purl.obolibrary.org/obo/UBERON_0005383) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Regional part of telencephalon in some species, e.g., rodent, equivalent to the dorsal striatum (caudate nucleus and putamen). Unlike the dorsal striatum of primates, for example, the caudoputamen is not split into separate nuclei by the fibers of the internal capsule. Rather, the internal capsule splits into fiber bundles which course through the structure."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "NLXANAT:100312"
-- [caudate-putamen](http://purl.obolibrary.org/obo/UBERON_0005383) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "MBA:672"
-- [caudate-putamen](http://purl.obolibrary.org/obo/UBERON_0005383) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "EFO:0001912"
+### blastula `http://purl.obolibrary.org/obo/UBERON_0000307`
+#### Removed
+- [blastula](http://purl.obolibrary.org/obo/UBERON_0000307) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### blood `http://purl.obolibrary.org/obo/UBERON_0000178`
+#### Removed
+- [blood](http://purl.obolibrary.org/obo/UBERON_0000178) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### blood clot `http://purl.obolibrary.org/obo/UBERON_0010210`
+#### Removed
+- [blood clot](http://purl.obolibrary.org/obo/UBERON_0010210) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### blood vasculature `http://purl.obolibrary.org/obo/UBERON_0004537`
+#### Removed
+- [blood vasculature](http://purl.obolibrary.org/obo/UBERON_0004537) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### blood vessel `http://purl.obolibrary.org/obo/UBERON_0001981`
+#### Removed
+- [blood vessel](http://purl.obolibrary.org/obo/UBERON_0001981) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### bone marrow macrophage `http://purl.obolibrary.org/obo/CL_0002476`
+#### Removed
+- [bone marrow macrophage](http://purl.obolibrary.org/obo/CL_0002476) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
+
+
+
+### bone marrow proteoglycan `http://purl.obolibrary.org/obo/PR_000013206`
+
+#### Added
+- [bone marrow proteoglycan](http://purl.obolibrary.org/obo/PR_000013206) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [bone marrow proteoglycan (human)](http://purl.obolibrary.org/obo/PR_P13727)
+
+
+### bone marrow stromal antigen 2 `http://purl.obolibrary.org/obo/PR_000001326`
+
+#### Added
+- [bone marrow stromal antigen 2](http://purl.obolibrary.org/obo/PR_000001326) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [bone marrow stromal antigen 2 (human)](http://purl.obolibrary.org/obo/PR_Q10589)
+
+
+### bony projection `http://purl.obolibrary.org/obo/UBERON_0004530`
+#### Removed
+- [bony projection](http://purl.obolibrary.org/obo/UBERON_0004530) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### brachial nerve plexus `http://purl.obolibrary.org/obo/UBERON_0001814`
+#### Removed
+- [brachial nerve plexus](http://purl.obolibrary.org/obo/UBERON_0001814) SubClassOf [neuron projection bundle](http://purl.obolibrary.org/obo/CARO_0001001)
+
+#### Added
+- [brachial nerve plexus](http://purl.obolibrary.org/obo/UBERON_0001814) SubClassOf [neuron projection bundle](http://purl.obolibrary.org/obo/UBERON_0000122)
+
+
+### brain marginal zone `http://purl.obolibrary.org/obo/UBERON_0010403`
+#### Removed
+- [brain marginal zone](http://purl.obolibrary.org/obo/UBERON_0010403) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### brainstem motor neuron `http://purl.obolibrary.org/obo/CL_2000047`
+#### Removed
+- [brainstem motor neuron](http://purl.obolibrary.org/obo/CL_2000047) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### branchiomotor neuron `http://purl.obolibrary.org/obo/CL_0005023`
+#### Removed
+- [branchiomotor neuron](http://purl.obolibrary.org/obo/CL_0005023) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### bronchial artery `http://purl.obolibrary.org/obo/UBERON_0002040`
+
+#### Added
+- [bronchial artery](http://purl.obolibrary.org/obo/UBERON_0002040) SubClassOf [has part](http://purl.obolibrary.org/obo/BFO_0000051) some [respiratory system arterial endothelium](http://purl.obolibrary.org/obo/UBERON_0004848)
+
+- [bronchial artery](http://purl.obolibrary.org/obo/UBERON_0002040) SubClassOf [has part](http://purl.obolibrary.org/obo/BFO_0000051) some [respiratory system arterial smooth muscle](http://purl.obolibrary.org/obo/UBERON_0012416)
+
+
+### bronchiolar smooth muscle cell `http://purl.obolibrary.org/obo/CL_4033017`
+#### Removed
+- [bronchiolar smooth muscle cell](http://purl.obolibrary.org/obo/CL_4033017) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [bronchiole](http://purl.obolibrary.org/obo/UBERON_0002186)
+
+#### Added
+- [bronchiolar smooth muscle cell](http://purl.obolibrary.org/obo/CL_4033017) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [smooth muscle tissue of bronchiole](http://purl.obolibrary.org/obo/UBERON_0004515)
+
+
+### buccopharyngeal membrane `http://purl.obolibrary.org/obo/UBERON_0006211`
+#### Removed
+- [buccopharyngeal membrane](http://purl.obolibrary.org/obo/UBERON_0006211) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### bushy cell `http://purl.obolibrary.org/obo/CL_4023162`
+#### Removed
+- [bushy cell](http://purl.obolibrary.org/obo/CL_4023162) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### cadherin-1 `http://purl.obolibrary.org/obo/PR_000001447`
+
+#### Added
+- [cadherin-1](http://purl.obolibrary.org/obo/PR_000001447) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [cadherin-1 (human)](http://purl.obolibrary.org/obo/PR_P12830)
+
+
+### cadherin-5 `http://purl.obolibrary.org/obo/PR_000001444`
+
+#### Added
+- [cadherin-5](http://purl.obolibrary.org/obo/PR_000001444) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [cadherin-5 (human)](http://purl.obolibrary.org/obo/PR_P33151)
+
+
+### caecum `http://purl.obolibrary.org/obo/UBERON_0001153`
+#### Removed
+- [caecum](http://purl.obolibrary.org/obo/UBERON_0001153) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### camera-type eye photoreceptor cell `http://purl.obolibrary.org/obo/CL_0010009`
+#### Removed
+- [camera-type eye photoreceptor cell](http://purl.obolibrary.org/obo/CL_0010009) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### canopy lamp5 GABAergic cortical interneuron (Mmus) `http://purl.obolibrary.org/obo/CL_4023022`
+
+#### Added
+- [canopy lamp5 GABAergic cortical interneuron (Mmus)](http://purl.obolibrary.org/obo/CL_4023022) [symbol](http://purl.obolibrary.org/obo/IAO_0000028) "canopy lamp5 interneuron"
+
+
+### carcinoembryonic antigen-related cell adhesion molecule 8 `http://purl.obolibrary.org/obo/PR_000001332`
+
+#### Added
+- [carcinoembryonic antigen-related cell adhesion molecule 8](http://purl.obolibrary.org/obo/PR_000001332) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [carcinoembryonic antigen-related cell adhesion molecule 8 (human)](http://purl.obolibrary.org/obo/PR_P31997)
+
+
+### cardiac nerve plexus `http://purl.obolibrary.org/obo/UBERON_0002008`
+#### Removed
+- [cardiac nerve plexus](http://purl.obolibrary.org/obo/UBERON_0002008) SubClassOf [neuron projection bundle](http://purl.obolibrary.org/obo/CARO_0001001)
+
+#### Added
+- [cardiac nerve plexus](http://purl.obolibrary.org/obo/UBERON_0002008) SubClassOf [neuron projection bundle](http://purl.obolibrary.org/obo/UBERON_0000122)
+
+
+### cardiac neuron `http://purl.obolibrary.org/obo/CL_0010022`
+#### Removed
+- [cardiac neuron](http://purl.obolibrary.org/obo/CL_0010022) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### cardiogenic plate `http://purl.obolibrary.org/obo/UBERON_0004139`
+#### Removed
+- [cardiogenic plate](http://purl.obolibrary.org/obo/UBERON_0004139) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### cardiogenic splanchnic mesoderm `http://purl.obolibrary.org/obo/UBERON_0007005`
+#### Removed
+- [cardiogenic splanchnic mesoderm](http://purl.obolibrary.org/obo/UBERON_0007005) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
+
+
+
+### cardiovascular system `http://purl.obolibrary.org/obo/UBERON_0004535`
+#### Removed
+- [cardiovascular system](http://purl.obolibrary.org/obo/UBERON_0004535) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
+
+
+
+### cartilaginous joint `http://purl.obolibrary.org/obo/UBERON_0002213`
+#### Removed
+- [cartilaginous joint](http://purl.obolibrary.org/obo/UBERON_0002213) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### cartilaginous neurocranium `http://purl.obolibrary.org/obo/UBERON_0004761`
+#### Removed
+- [cartilaginous neurocranium](http://purl.obolibrary.org/obo/UBERON_0004761) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
+
+
+
+### cartilaginous projection `http://purl.obolibrary.org/obo/UBERON_0011769`
+#### Removed
+- [cartilaginous projection](http://purl.obolibrary.org/obo/UBERON_0011769) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### cartwheel cell `http://purl.obolibrary.org/obo/CL_4023160`
+#### Removed
+- [cartwheel cell](http://purl.obolibrary.org/obo/CL_4023160) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+- [cartwheel cell](http://purl.obolibrary.org/obo/CL_4023160) SubClassOf [synapsed_by](http://purl.obolibrary.org/obo/uberon/core#synapsed_by) some [granule cell](http://purl.obolibrary.org/obo/CL_0000120)
+
+#### Added
+- [cartwheel cell](http://purl.obolibrary.org/obo/CL_4023160) SubClassOf [synapsed by](http://purl.obolibrary.org/obo/RO_0002103) some [granule cell](http://purl.obolibrary.org/obo/CL_0000120)
+
+
+### cathepsin K `http://purl.obolibrary.org/obo/PR_000001850`
+
+#### Added
+- [cathepsin K](http://purl.obolibrary.org/obo/PR_000001850) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [cathepsin K (human)](http://purl.obolibrary.org/obo/PR_P43235)
+
+
+### caudal ganglionic eminence derived GABAergic cortical interneuron `http://purl.obolibrary.org/obo/CL_4023070`
+
+#### Added
+- [caudal ganglionic eminence derived GABAergic cortical interneuron](http://purl.obolibrary.org/obo/CL_4023070) [symbol](http://purl.obolibrary.org/obo/IAO_0000028) "CGE gaba cortical interneuron"
+
+
+### caudal ganglionic eminence derived interneuron `http://purl.obolibrary.org/obo/CL_4023064`
+#### Removed
+- [caudal ganglionic eminence derived interneuron](http://purl.obolibrary.org/obo/CL_4023064) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+#### Added
+- [caudal ganglionic eminence derived interneuron](http://purl.obolibrary.org/obo/CL_4023064) [symbol](http://purl.obolibrary.org/obo/IAO_0000028) "CGE interneuron"
+
+
+### caudal region `http://purl.obolibrary.org/obo/UBERON_0006071`
+#### Removed
+- [caudal region](http://purl.obolibrary.org/obo/UBERON_0006071) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000)
+
+
+
+### causally upstream of or within, negative effect `http://purl.obolibrary.org/obo/RO_0004046`
+
+#### Added
+- [causally upstream of or within, negative effect](http://purl.obolibrary.org/obo/RO_0004046) [see also](http://www.w3.org/2000/01/rdf-schema#seeAlso) "https://wiki.geneontology.org/Causally_upstream_of_or_within,_negative_effect"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI)
+
+
+### causally upstream of or within, positive effect `http://purl.obolibrary.org/obo/RO_0004047`
+
+#### Added
+- [causally upstream of or within, positive effect](http://purl.obolibrary.org/obo/RO_0004047) [see also](http://www.w3.org/2000/01/rdf-schema#seeAlso) [_positive_effect](https://wiki.geneontology.org/Causally_upstream_of_or_within,_positive_effect)
+
+
+### causally upstream of, negative effect `http://purl.obolibrary.org/obo/RO_0002305`
+
+#### Added
+- [causally upstream of, negative effect](http://purl.obolibrary.org/obo/RO_0002305) [see also](http://www.w3.org/2000/01/rdf-schema#seeAlso) [_negative_effect](https://wiki.geneontology.org/Causally_upstream_of,_negative_effect)
+
+
+### causally upstream of, positive effect `http://purl.obolibrary.org/obo/RO_0002304`
+
+#### Added
+- [causally upstream of, positive effect](http://purl.obolibrary.org/obo/RO_0002304) [see also](http://www.w3.org/2000/01/rdf-schema#seeAlso) [_positive_effect](https://wiki.geneontology.org/Causally_upstream_of,_positive_effect)
+
+
+### cavity of pharynx `http://purl.obolibrary.org/obo/UBERON_0001731`
+#### Removed
+- [cavity of pharynx](http://purl.obolibrary.org/obo/UBERON_0001731) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### central tendon of diaphragm `http://purl.obolibrary.org/obo/UBERON_0006670`
+#### Removed
+- [central tendon of diaphragm](http://purl.obolibrary.org/obo/UBERON_0006670) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000)
+
+
+
+### cerebellar granule cell `http://purl.obolibrary.org/obo/CL_0001031`
+#### Removed
+- [cerebellar granule cell](http://purl.obolibrary.org/obo/CL_0001031) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Granule cell that is part of the cerebellum."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:mah"
+
+- [cerebellar granule cell](http://purl.obolibrary.org/obo/CL_0001031) SubClassOf [granule cell](http://purl.obolibrary.org/obo/CL_0000120)
+ - [is_inferred](http://www.geneontology.org/formats/oboInOwl#is_inferred) "true"
+
+- [cerebellar granule cell](http://purl.obolibrary.org/obo/CL_0001031) SubClassOf [cerebellar neuron](http://purl.obolibrary.org/obo/CL_1001611)
+
+#### Added
+- [cerebellar granule cell](http://purl.obolibrary.org/obo/CL_0001031) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "An excitatory granule cell with a soma located in the granular layer of cerebellar cortex. A mature cerebellar granule cell has short dendrites with a characteristic claw-like appearance and a long axon that ascends to the molecular layer where it bifurcates (except in non-teleost fish, where it does not bifurcate) and extends mediolaterally to form parallel fibers."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:mah"
+
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.3389/fncir.2020.611841"
+
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.12688/f1000research.15021.1"
+
+- [cerebellar granule cell](http://purl.obolibrary.org/obo/CL_0001031) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "granule cell of the cerebellum"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.3389/fncir.2020.611841"
+
+- [cerebellar granule cell](http://purl.obolibrary.org/obo/CL_0001031) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "It has been noted in at least some mammalian species that granule cells are the most numerous cell type in the cerebellum and in the brain, with at least 99% of all cerebellar neurons being granule cells."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.3389/fncir.2020.611841"
+
+- [cerebellar granule cell](http://purl.obolibrary.org/obo/CL_0001031) SubClassOf [cerebellum glutamatergic neuron](http://purl.obolibrary.org/obo/CL_2000028)
+
+- [cerebellar granule cell](http://purl.obolibrary.org/obo/CL_0001031) SubClassOf [ectoderm-derived structure](http://purl.obolibrary.org/obo/UBERON_0004121)
+
+- [cerebellar granule cell](http://purl.obolibrary.org/obo/CL_0001031) SubClassOf [granule cell](http://purl.obolibrary.org/obo/CL_0000120)
+
+- [cerebellar granule cell](http://purl.obolibrary.org/obo/CL_0001031) SubClassOf [directly develops from](http://purl.obolibrary.org/obo/RO_0002207) some [granule cell precursor](http://purl.obolibrary.org/obo/CL_0002362)
+
+
+### cerebellar granule cell differentiation `http://purl.obolibrary.org/obo/GO_0021707`
+
+#### Added
+- [cerebellar granule cell differentiation](http://purl.obolibrary.org/obo/GO_0021707) SubClassOf [glutamatergic neuron differentiation](http://purl.obolibrary.org/obo/GO_1905962)
+
+
+### cerebellar neuron `http://purl.obolibrary.org/obo/CL_1001611`
+#### Removed
+- [cerebellar neuron](http://purl.obolibrary.org/obo/CL_1001611) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### cerebral cortex `http://purl.obolibrary.org/obo/UBERON_0000956`
+#### Removed
+- [cerebral cortex](http://purl.obolibrary.org/obo/UBERON_0000956) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### cerebral cortex marginal layer `http://purl.obolibrary.org/obo/UBERON_0014935`
+#### Removed
+- [cerebral cortex marginal layer](http://purl.obolibrary.org/obo/UBERON_0014935) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### cerebral cortex neuron `http://purl.obolibrary.org/obo/CL_0010012`
+#### Removed
+- [cerebral cortex neuron](http://purl.obolibrary.org/obo/CL_0010012) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### chandelier pvalb GABAergic cortical interneuron `http://purl.obolibrary.org/obo/CL_4023036`
+
+#### Added
+- [chandelier pvalb GABAergic cortical interneuron](http://purl.obolibrary.org/obo/CL_4023036) [symbol](http://purl.obolibrary.org/obo/IAO_0000028) "chandelier PV interneuron"
+
+
+### cholangiocyte `http://purl.obolibrary.org/obo/CL_1000488`
+#### Removed
+- [cholangiocyte](http://purl.obolibrary.org/obo/CL_1000488) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### cholecystokinin `http://purl.obolibrary.org/obo/PR_000005110`
+
+#### Added
+- [cholecystokinin](http://purl.obolibrary.org/obo/PR_000005110) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [cholecystokinin (human)](http://purl.obolibrary.org/obo/PR_P06307)
+
+
+### chondroblast `http://purl.obolibrary.org/obo/CL_0000058`
+#### Removed
+- [chondroblast](http://purl.obolibrary.org/obo/CL_0000058) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### chondrolectin `http://purl.obolibrary.org/obo/PR_000005444`
+
+#### Added
+- [chondrolectin](http://purl.obolibrary.org/obo/PR_000005444) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [chondrolectin (human)](http://purl.obolibrary.org/obo/PR_Q9H9P2)
+
+
+### chordate pharynx `http://purl.obolibrary.org/obo/UBERON_0001042`
+#### Removed
+- [chordate pharynx](http://purl.obolibrary.org/obo/UBERON_0001042) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### chorion membrane `http://purl.obolibrary.org/obo/UBERON_0003124`
+#### Removed
+- [chorion membrane](http://purl.obolibrary.org/obo/UBERON_0003124) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### chorionic ectoderm `http://purl.obolibrary.org/obo/UBERON_0003374`
+#### Removed
+- [chorionic ectoderm](http://purl.obolibrary.org/obo/UBERON_0003374) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### chorionic villus `http://purl.obolibrary.org/obo/UBERON_0007106`
+#### Removed
+- [chorionic villus](http://purl.obolibrary.org/obo/UBERON_0007106) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### chorioretinal region `http://purl.obolibrary.org/obo/UBERON_0019207`
+#### Removed
+- [chorioretinal region](http://purl.obolibrary.org/obo/UBERON_0019207) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### choroid plexus stroma `http://purl.obolibrary.org/obo/UBERON_0005206`
+#### Removed
+- [choroid plexus stroma](http://purl.obolibrary.org/obo/UBERON_0005206) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### choroidal cell of the eye `http://purl.obolibrary.org/obo/CL_0000348`
+#### Removed
+- [choroidal cell of the eye](http://purl.obolibrary.org/obo/CL_0000348) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### ciliary body `http://purl.obolibrary.org/obo/UBERON_0001775`
+#### Removed
+- [ciliary body](http://purl.obolibrary.org/obo/UBERON_0001775) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
+
+
+
+### classical monocyte `http://purl.obolibrary.org/obo/CL_0000860`
+#### Removed
+- [classical monocyte](http://purl.obolibrary.org/obo/CL_0000860) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
+
+
+
+### clavicle bone primordium `http://purl.obolibrary.org/obo/UBERON_0010905`
+#### Removed
+- [clavicle bone primordium](http://purl.obolibrary.org/obo/UBERON_0010905) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### cloacal membrane `http://purl.obolibrary.org/obo/UBERON_0006217`
+#### Removed
+- [cloacal membrane](http://purl.obolibrary.org/obo/UBERON_0006217) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### club cell `http://purl.obolibrary.org/obo/CL_0000158`
+#### Removed
+- [club cell](http://purl.obolibrary.org/obo/CL_0000158) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
+
+
+
+### cochlear nerve `http://purl.obolibrary.org/obo/UBERON_0004727`
+#### Removed
+- [cochlear nerve](http://purl.obolibrary.org/obo/UBERON_0004727) SubClassOf [neuron projection bundle](http://purl.obolibrary.org/obo/CARO_0001001)
+
+
+
+### coelemic cavity lumen `http://purl.obolibrary.org/obo/UBERON_0002323`
+#### Removed
+- [coelemic cavity lumen](http://purl.obolibrary.org/obo/UBERON_0002323) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### coelomic epithelium `http://purl.obolibrary.org/obo/UBERON_0005891`
+#### Removed
+- [coelomic epithelium](http://purl.obolibrary.org/obo/UBERON_0005891) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### collagen alpha-1(I) chain `http://purl.obolibrary.org/obo/PR_000003264`
+
+#### Added
+- [collagen alpha-1(I) chain](http://purl.obolibrary.org/obo/PR_000003264) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [collagen alpha-1(I) chain (human)](http://purl.obolibrary.org/obo/PR_P02452)
+
+
+### collection of hairs `http://purl.obolibrary.org/obo/UBERON_0010164`
+#### Removed
+- [collection of hairs](http://purl.obolibrary.org/obo/UBERON_0010164) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
+
+
+
+### comma-shaped body `http://purl.obolibrary.org/obo/UBERON_0004198`
+#### Removed
+- [comma-shaped body](http://purl.obolibrary.org/obo/UBERON_0004198) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### common dendritic progenitor `http://purl.obolibrary.org/obo/CL_0001029`
+#### Removed
+- [common dendritic progenitor](http://purl.obolibrary.org/obo/CL_0001029) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
+
+
+
+### common myeloid progenitor, CD34-positive `http://purl.obolibrary.org/obo/CL_0001059`
+#### Removed
+- [common myeloid progenitor, CD34-positive](http://purl.obolibrary.org/obo/CL_0001059) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
+
+
+
+### complement component C1q receptor `http://purl.obolibrary.org/obo/PR_000002037`
+
+#### Added
+- [complement component C1q receptor](http://purl.obolibrary.org/obo/PR_000002037) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [complement component C1q receptor (human)](http://purl.obolibrary.org/obo/PR_Q9NPY3)
+
+
+### complement receptor type 1 `http://purl.obolibrary.org/obo/PR_000001337`
+
+#### Added
+- [complement receptor type 1](http://purl.obolibrary.org/obo/PR_000001337) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [complement receptor type 1 (human)](http://purl.obolibrary.org/obo/PR_P17927)
+
+
+### complement receptor type 2 `http://purl.obolibrary.org/obo/PR_000001338`
+
+#### Added
+- [complement receptor type 2](http://purl.obolibrary.org/obo/PR_000001338) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [complement receptor type 2 (human)](http://purl.obolibrary.org/obo/PR_P20023)
+
+
+### conceptus `http://purl.obolibrary.org/obo/UBERON_0004716`
+#### Removed
+- [conceptus](http://purl.obolibrary.org/obo/UBERON_0004716) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### conjunctiva `http://purl.obolibrary.org/obo/UBERON_0001811`
+#### Removed
+- [conjunctiva](http://purl.obolibrary.org/obo/UBERON_0001811) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### connecting stalk `http://purl.obolibrary.org/obo/UBERON_0007806`
+#### Removed
+- [connecting stalk](http://purl.obolibrary.org/obo/UBERON_0007806) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### connecting stalk vasculature `http://purl.obolibrary.org/obo/UBERON_0007807`
+#### Removed
+- [connecting stalk vasculature](http://purl.obolibrary.org/obo/UBERON_0007807) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### conventional dendritic cell `http://purl.obolibrary.org/obo/CL_0000990`
+#### Removed
+- [conventional dendritic cell](http://purl.obolibrary.org/obo/CL_0000990) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
+
+
+
+### cornea `http://purl.obolibrary.org/obo/UBERON_0000964`
+#### Removed
+- [cornea](http://purl.obolibrary.org/obo/UBERON_0000964) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
+
+
+
+### corneal epithelium `http://purl.obolibrary.org/obo/UBERON_0001772`
+#### Removed
+- [corneal epithelium](http://purl.obolibrary.org/obo/UBERON_0001772) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### corneocyte `http://purl.obolibrary.org/obo/CL_0002153`
+#### Removed
+- [corneocyte](http://purl.obolibrary.org/obo/CL_0002153) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### correlated with `http://purl.obolibrary.org/obo/RO_0002610`
+
+#### Added
+- [correlated with](http://purl.obolibrary.org/obo/RO_0002610) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A relationship that holds between two entities, where the entities exhibit a statistical dependence relationship. The entities may be statistical variables, or they may be other kinds of entities such as diseases, chemical entities or processes."
+
+- [correlated with](http://purl.obolibrary.org/obo/RO_0002610) [IAO_0000232](http://purl.obolibrary.org/obo/IAO_0000232) "Groups both positive and negative correlation"
+
+- [correlated with](http://purl.obolibrary.org/obo/RO_0002610) [label](http://www.w3.org/2000/01/rdf-schema#label) "correlated with"
+
+- ObjectProperty: [correlated with](http://purl.obolibrary.org/obo/RO_0002610)
+
+
+### cortex of thymus `http://purl.obolibrary.org/obo/UBERON_0002123`
+#### Removed
+- [cortex of thymus](http://purl.obolibrary.org/obo/UBERON_0002123) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### cortical intermediate zone `http://purl.obolibrary.org/obo/UBERON_0004040`
+#### Removed
+- [cortical intermediate zone](http://purl.obolibrary.org/obo/UBERON_0004040) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### cortical layer I `http://purl.obolibrary.org/obo/UBERON_0005390`
+#### Removed
+- [cortical layer I](http://purl.obolibrary.org/obo/UBERON_0005390) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### cortical layer II `http://purl.obolibrary.org/obo/UBERON_0005391`
+#### Removed
+- [cortical layer II](http://purl.obolibrary.org/obo/UBERON_0005391) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### cortical layer III `http://purl.obolibrary.org/obo/UBERON_0005392`
+#### Removed
+- [cortical layer III](http://purl.obolibrary.org/obo/UBERON_0005392) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### cortical layer IV `http://purl.obolibrary.org/obo/UBERON_0005393`
+#### Removed
+- [cortical layer IV](http://purl.obolibrary.org/obo/UBERON_0005393) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### cortical layer V `http://purl.obolibrary.org/obo/UBERON_0005394`
+#### Removed
+- [cortical layer V](http://purl.obolibrary.org/obo/UBERON_0005394) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### cortical layer VIb `http://purl.obolibrary.org/obo/UBERON_8440003`
+#### Removed
+- [cortical layer VIb](http://purl.obolibrary.org/obo/UBERON_8440003) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### cortical plate `http://purl.obolibrary.org/obo/UBERON_0005343`
+#### Removed
+- [cortical plate](http://purl.obolibrary.org/obo/UBERON_0005343) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### cortical subplate `http://purl.obolibrary.org/obo/UBERON_0004035`
+#### Removed
+- [cortical subplate](http://purl.obolibrary.org/obo/UBERON_0004035) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### corticothalamic VAL/VM projecting glutamatergic neuron of the primary motor cortex `http://purl.obolibrary.org/obo/CL_4023055`
+
+#### Added
+- [corticothalamic VAL/VM projecting glutamatergic neuron of the primary motor cortex](http://purl.obolibrary.org/obo/CL_4023055) [symbol](http://purl.obolibrary.org/obo/IAO_0000028) "CT VAL/VM glut MOp"
+
+
+### corticothalamic-projecting glutamatergic cortical neuron `http://purl.obolibrary.org/obo/CL_4023013`
+
+#### Added
+- [corticothalamic-projecting glutamatergic cortical neuron](http://purl.obolibrary.org/obo/CL_4023013) [symbol](http://purl.obolibrary.org/obo/IAO_0000028) "CT glut"
+
+
+### cranial nerve `http://purl.obolibrary.org/obo/UBERON_0001785`
+#### Removed
+- [cranial nerve](http://purl.obolibrary.org/obo/UBERON_0001785) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### cranial nerve II `http://purl.obolibrary.org/obo/UBERON_0000941`
+#### Removed
+- [cranial nerve II](http://purl.obolibrary.org/obo/UBERON_0000941) SubClassOf [neuron projection bundle](http://purl.obolibrary.org/obo/CARO_0001001)
+
+
+
+### cranial neural crest `http://purl.obolibrary.org/obo/UBERON_0003099`
+#### Removed
+- [cranial neural crest](http://purl.obolibrary.org/obo/UBERON_0003099) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### cranial suture `http://purl.obolibrary.org/obo/UBERON_0003685`
+#### Removed
+- [cranial suture](http://purl.obolibrary.org/obo/UBERON_0003685) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
+
+
+
+### crista ampullaris neuroepithelium `http://purl.obolibrary.org/obo/UBERON_0006935`
+#### Removed
+- [crista ampullaris neuroepithelium](http://purl.obolibrary.org/obo/UBERON_0006935) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### crossSpeciesExactMatch `https://w3id.org/semapv/vocab/crossSpeciesExactMatch`
+
+#### Added
+- AnnotationProperty: [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch)
+
+
+### curation status specification `http://purl.obolibrary.org/obo/IAO_0000078`
+
+#### Added
+- [curation status specification](http://purl.obolibrary.org/obo/IAO_0000078) [IAO_0000117](http://purl.obolibrary.org/obo/IAO_0000117) "PERSON:Bill Bug"@en
+
+- [curation status specification](http://purl.obolibrary.org/obo/IAO_0000078) [IAO_0000114](http://purl.obolibrary.org/obo/IAO_0000114) [pending final vetting](http://purl.obolibrary.org/obo/IAO_0000125)
+
+- [curation status specification](http://purl.obolibrary.org/obo/IAO_0000078) [label](http://www.w3.org/2000/01/rdf-schema#label) "curation status specification"@en
+
+- [curation status specification](http://purl.obolibrary.org/obo/IAO_0000078) [IAO_0000119](http://purl.obolibrary.org/obo/IAO_0000119) "OBI_0000266"@en
+
+- [curation status specification](http://purl.obolibrary.org/obo/IAO_0000078) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The curation status of the term. The allowed values come from an enumerated list of predefined terms. See the specification of these instances for more detailed definitions of each enumerated value."@en
+
+- [curation status specification](http://purl.obolibrary.org/obo/IAO_0000078) [IAO_0000119](http://purl.obolibrary.org/obo/IAO_0000119) "GROUP:OBI:<http://purl.obolibrary.org/obo/obi>"@en
+
+- [curation status specification](http://purl.obolibrary.org/obo/IAO_0000078) [editor note](http://purl.obolibrary.org/obo/IAO_0000116) "Better to represent curation as a process with parts and then relate labels to that process (in IAO meeting)"@en
+
+- [curation status specification](http://purl.obolibrary.org/obo/IAO_0000078) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "curation status specification"@en
+
+- Class: [curation status specification](http://purl.obolibrary.org/obo/IAO_0000078)
+
+- [curation status specification](http://purl.obolibrary.org/obo/IAO_0000078) EquivalentTo {[example to be eventually removed](http://purl.obolibrary.org/obo/IAO_0000002) , [metadata complete](http://purl.obolibrary.org/obo/IAO_0000120) , [organizational term](http://purl.obolibrary.org/obo/IAO_0000121) , [ready for release](http://purl.obolibrary.org/obo/IAO_0000122) , [metadata incomplete](http://purl.obolibrary.org/obo/IAO_0000123) , [uncurated](http://purl.obolibrary.org/obo/IAO_0000124) , [pending final vetting](http://purl.obolibrary.org/obo/IAO_0000125) , [to be replaced with external ontology term](http://purl.obolibrary.org/obo/IAO_0000423) , [requires discussion](http://purl.obolibrary.org/obo/IAO_0000428)}
+
+- [curation status specification](http://purl.obolibrary.org/obo/IAO_0000078) SubClassOf [data about an ontology part](http://purl.obolibrary.org/obo/IAO_0000102)
+
+
+### cutaneous appendage `http://purl.obolibrary.org/obo/UBERON_0000021`
+#### Removed
+- [cutaneous appendage](http://purl.obolibrary.org/obo/UBERON_0000021) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000)
+
+
+
+### cyanophore `http://purl.obolibrary.org/obo/CL_0000747`
+#### Removed
+- [cyanophore](http://purl.obolibrary.org/obo/CL_0000747) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### cytotoxic T-lymphocyte protein 4 `http://purl.obolibrary.org/obo/PR_000001852`
+
+#### Added
+- [cytotoxic T-lymphocyte protein 4](http://purl.obolibrary.org/obo/PR_000001852) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [cytotoxic T-lymphocyte protein 4 (human)](http://purl.obolibrary.org/obo/PR_P16410)
+
+
+### data about an ontology part `http://purl.obolibrary.org/obo/IAO_0000102`
+
+#### Added
+- [data about an ontology part](http://purl.obolibrary.org/obo/IAO_0000102) [IAO_0000117](http://purl.obolibrary.org/obo/IAO_0000117) "Person:Alan Ruttenberg"@en
+
+- [data about an ontology part](http://purl.obolibrary.org/obo/IAO_0000102) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Data about an ontology part is a data item about a part of an ontology, for example a term"@en
+
+- [data about an ontology part](http://purl.obolibrary.org/obo/IAO_0000102) [label](http://www.w3.org/2000/01/rdf-schema#label) "data about an ontology part"@en
+
+- [data about an ontology part](http://purl.obolibrary.org/obo/IAO_0000102) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "data about an ontology part"@en
+
+- Class: [data about an ontology part](http://purl.obolibrary.org/obo/IAO_0000102)
+
+- [data about an ontology part](http://purl.obolibrary.org/obo/IAO_0000102) SubClassOf [data item](http://purl.obolibrary.org/obo/IAO_0000027)
+
+
+### data item `http://purl.obolibrary.org/obo/IAO_0000027`
+
+#### Added
+- [data item](http://purl.obolibrary.org/obo/IAO_0000027) [IAO_0000117](http://purl.obolibrary.org/obo/IAO_0000117) "PERSON: Alan Ruttenberg"@en
+
+- [data item](http://purl.obolibrary.org/obo/IAO_0000027) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "An information content entity that is intended to be a truthful statement about something (modulo, e.g., measurement precision or other systematic errors) and is constructed/acquired by a method which reliably tends to produce (approximately) truthful statements."@en
+
+- [data item](http://purl.obolibrary.org/obo/IAO_0000027) [IAO_0000112](http://purl.obolibrary.org/obo/IAO_0000112) "Data items include counts of things, analyte concentrations, and statistical summaries."@en
+
+- [data item](http://purl.obolibrary.org/obo/IAO_0000027) [label](http://www.w3.org/2000/01/rdf-schema#label) "data item"@en
+
+- [data item](http://purl.obolibrary.org/obo/IAO_0000027) [IAO_0000117](http://purl.obolibrary.org/obo/IAO_0000117) "PERSON: Jonathan Rees"@en
+
+- [data item](http://purl.obolibrary.org/obo/IAO_0000027) [IAO_0000118](http://purl.obolibrary.org/obo/IAO_0000118) "data"@en
+
+- [data item](http://purl.obolibrary.org/obo/IAO_0000027) [editor note](http://purl.obolibrary.org/obo/IAO_0000116) "2009-03-16: data item deliberatly ambiguous: we merged data set and datum to be one entity, not knowing how to define singular versus plural. So data item is more general than datum."@en
+
+- [data item](http://purl.obolibrary.org/obo/IAO_0000027) [editor note](http://purl.obolibrary.org/obo/IAO_0000116) "2009-03-16: removed datum as alternative term as datum specifically refers to singular form, and is thus not an exact synonym."@en
+
+- [data item](http://purl.obolibrary.org/obo/IAO_0000027) [editor note](http://purl.obolibrary.org/obo/IAO_0000116) "JAR: datum -- well, this will be very tricky to define, but maybe some
+information-like stuff that might be put into a computer and that is
+meant, by someone, to denote and/or to be interpreted by some
+process... I would include lists, tables, sentences... I think I might
+defer to Barry, or to Brian Cantwell Smith
+
+JAR: A data item is an approximately justified approximately true approximate belief"@en
+
+- [data item](http://purl.obolibrary.org/obo/IAO_0000027) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "data item"@en
+
+- [data item](http://purl.obolibrary.org/obo/IAO_0000027) [editor note](http://purl.obolibrary.org/obo/IAO_0000116) "2/2/2009 Alan and Bjoern discussing FACS run output data. This is a data item because it is about the cell population. Each element records an event and is typically further composed a set of measurment data items that record the fluorescent intensity stimulated by one of the lasers."@en
+
+- [data item](http://purl.obolibrary.org/obo/IAO_0000027) [IAO_0000117](http://purl.obolibrary.org/obo/IAO_0000117) "PERSON: Chris Stoeckert"@en
+
+- [data item](http://purl.obolibrary.org/obo/IAO_0000027) [editor note](http://purl.obolibrary.org/obo/IAO_0000116) "2014-03-31: See discussion at http://odontomachus.wordpress.com/2014/03/30/aboutness-objects-propositions/"
+
+- [data item](http://purl.obolibrary.org/obo/IAO_0000027) [IAO_0000114](http://purl.obolibrary.org/obo/IAO_0000114) [pending final vetting](http://purl.obolibrary.org/obo/IAO_0000125)
+
+- Class: [data item](http://purl.obolibrary.org/obo/IAO_0000027)
+
+- [data item](http://purl.obolibrary.org/obo/IAO_0000027) SubClassOf [information content entity](http://purl.obolibrary.org/obo/IAO_0000030)
+
+
+### decidua `http://purl.obolibrary.org/obo/UBERON_0002450`
+#### Removed
+- [decidua](http://purl.obolibrary.org/obo/UBERON_0002450) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### decidual natural killer cell, human `http://purl.obolibrary.org/obo/CL_0002343`
+#### Removed
+- [decidual natural killer cell, human](http://purl.obolibrary.org/obo/CL_0002343) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
+
+
+
+### defined class `http://purl.obolibrary.org/obo/IAO_0000420`
+
+#### Added
+- [defined class](http://purl.obolibrary.org/obo/IAO_0000420) [IAO_0000117](http://purl.obolibrary.org/obo/IAO_0000117) "Alan Ruttenberg"@en
+
+- [defined class](http://purl.obolibrary.org/obo/IAO_0000420) [editor note](http://purl.obolibrary.org/obo/IAO_0000116) ""definitions", in some readings, always are given by necessary and sufficient conditions. So one must be careful (and this is difficult sometimes) to distinguish between defined classes and universal."@en
+
+- [defined class](http://purl.obolibrary.org/obo/IAO_0000420) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "defined class"@en
+
+- [defined class](http://purl.obolibrary.org/obo/IAO_0000420) [label](http://www.w3.org/2000/01/rdf-schema#label) "defined class"@en
+
+- [defined class](http://purl.obolibrary.org/obo/IAO_0000420) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A defined class is a class that is defined by a set of logically necessary and sufficient conditions but is not a universal"@en
+
+- Individual: [defined class](http://purl.obolibrary.org/obo/IAO_0000420)
+
+
+### definition `http://purl.obolibrary.org/obo/IAO_0000115`
+
+#### Added
+- [definition](http://purl.obolibrary.org/obo/IAO_0000115) [IAO_0000114](http://purl.obolibrary.org/obo/IAO_0000114) [ready for release](http://purl.obolibrary.org/obo/IAO_0000122)
+
+- [definition](http://purl.obolibrary.org/obo/IAO_0000115) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "definition"@en
+
+- [definition](http://purl.obolibrary.org/obo/IAO_0000115) [editor note](http://purl.obolibrary.org/obo/IAO_0000116) "2012-04-05:
+Barry Smith
+
+The official OBI definition, explaining the meaning of a class or property: 'Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions' is terrible.
+
+Can you fix to something like:
+
+A statement of necessary and sufficient conditions explaining the meaning of an expression referring to a class or property.
+
+Alan Ruttenberg
+
+Your proposed definition is a reasonable candidate, except that it is very common that necessary and sufficient conditions are not given. Mostly they are necessary, occasionally they are necessary and sufficient or just sufficient. Often they use terms that are not themselves defined and so they effectively can't be evaluated by those criteria.
+
+On the specifics of the proposed definition:
+
+We don't have definitions of 'meaning' or 'expression' or 'property'. For 'reference' in the intended sense I think we use the term 'denotation'. For 'expression', I think we you mean symbol, or identifier. For 'meaning' it differs for class and property. For class we want documentation that let's the intended reader determine whether an entity is instance of the class, or not. For property we want documentation that let's the intended reader determine, given a pair of potential relata, whether the assertion that the relation holds is true. The 'intended reader' part suggests that we also specify who, we expect, would be able to understand the definition, and also generalizes over human and computer reader to include textual and logical definition.
+
+Personally, I am more comfortable weakening definition to documentation, with instructions as to what is desirable.
+
+We also have the outstanding issue of how to aim different definitions to different audiences. A clinical audience reading chebi wants a different sort of definition documentation/definition from a chemistry trained audience, and similarly there is a need for a definition that is adequate for an ontologist to work with. "@en
+
+- [definition](http://purl.obolibrary.org/obo/IAO_0000115) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The official definition, explaining the meaning of a class or property. Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions."@en
+
+- [definition](http://purl.obolibrary.org/obo/IAO_0000115) [label](http://www.w3.org/2000/01/rdf-schema#label) "definition"@en
+
+- [definition](http://purl.obolibrary.org/obo/IAO_0000115) [isDefinedBy](http://www.w3.org/2000/01/rdf-schema#isDefinedBy) [iao.owl](http://purl.obolibrary.org/obo/iao.owl)
+
+- [definition](http://purl.obolibrary.org/obo/IAO_0000115) [IAO_0000119](http://purl.obolibrary.org/obo/IAO_0000119) "GROUP:OBI:<http://purl.obolibrary.org/obo/obi>"@en
+
+- [definition](http://purl.obolibrary.org/obo/IAO_0000115) [IAO_0000117](http://purl.obolibrary.org/obo/IAO_0000117) "PERSON:Daniel Schober"@en
+
+
+### dendritic cell, human `http://purl.obolibrary.org/obo/CL_0001056`
+#### Removed
+- [dendritic cell, human](http://purl.obolibrary.org/obo/CL_0001056) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
+
+
+
+### denotator type `http://purl.obolibrary.org/obo/IAO_0000409`
+
+#### Added
+- [denotator type](http://purl.obolibrary.org/obo/IAO_0000409) [IAO_0000112](http://purl.obolibrary.org/obo/IAO_0000112) "The Basic Formal Ontology ontology makes a distinction between Universals and defined classes, where the formal are "natural kinds" and the latter arbitrary collections of entities."@en
+
+- [denotator type](http://purl.obolibrary.org/obo/IAO_0000409) [IAO_0000119](http://purl.obolibrary.org/obo/IAO_0000119) "Barry Smith, Werner Ceusters"@en
+
+- [denotator type](http://purl.obolibrary.org/obo/IAO_0000409) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "denotator type"@en
+
+- [denotator type](http://purl.obolibrary.org/obo/IAO_0000409) [label](http://www.w3.org/2000/01/rdf-schema#label) "denotator type"@en
+
+- [denotator type](http://purl.obolibrary.org/obo/IAO_0000409) [IAO_0000117](http://purl.obolibrary.org/obo/IAO_0000117) "Alan Ruttenberg"@en
+
+- [denotator type](http://purl.obolibrary.org/obo/IAO_0000409) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A denotator type indicates how a term should be interpreted from an ontological perspective."@en
+
+- Class: [denotator type](http://purl.obolibrary.org/obo/IAO_0000409)
+
+- [denotator type](http://purl.obolibrary.org/obo/IAO_0000409) EquivalentTo {[universal](http://purl.obolibrary.org/obo/IAO_0000410) , [defined class](http://purl.obolibrary.org/obo/IAO_0000420) , [named class expression](http://purl.obolibrary.org/obo/IAO_0000421)}
+
+- [denotator type](http://purl.obolibrary.org/obo/IAO_0000409) SubClassOf [data about an ontology part](http://purl.obolibrary.org/obo/IAO_0000102)
+
+
+### dense mesenchyme tissue `http://purl.obolibrary.org/obo/UBERON_0007524`
+#### Removed
+- [dense mesenchyme tissue](http://purl.obolibrary.org/obo/UBERON_0007524) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### dental epithelium `http://purl.obolibrary.org/obo/UBERON_0003843`
+#### Removed
+- [dental epithelium](http://purl.obolibrary.org/obo/UBERON_0003843) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### dental papilla cell `http://purl.obolibrary.org/obo/CL_0000345`
+#### Removed
+- [dental papilla cell](http://purl.obolibrary.org/obo/CL_0000345) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### dental pulp `http://purl.obolibrary.org/obo/UBERON_0001754`
+#### Removed
+- [dental pulp](http://purl.obolibrary.org/obo/UBERON_0001754) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### dentate gyrus granule cell layer `http://purl.obolibrary.org/obo/UBERON_0005381`
+#### Removed
+- [dentate gyrus granule cell layer](http://purl.obolibrary.org/obo/UBERON_0005381) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### dentate gyrus of hippocampal formation granule cell `http://purl.obolibrary.org/obo/CL_2000089`
+#### Removed
+- [dentate gyrus of hippocampal formation granule cell](http://purl.obolibrary.org/obo/CL_2000089) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "The granule cell has a characteristic cone-shaped tree of spiny apical dendrites."
+
+- [dentate gyrus of hippocampal formation granule cell](http://purl.obolibrary.org/obo/CL_2000089) [label](http://www.w3.org/2000/01/rdf-schema#label) "dentate gyrus of hippocampal formation granule cell"
+
+- [dentate gyrus of hippocampal formation granule cell](http://purl.obolibrary.org/obo/CL_2000089) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The principal cell type of the dentate gyrus."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie"
+
+- [dentate gyrus of hippocampal formation granule cell](http://purl.obolibrary.org/obo/CL_2000089) EquivalentTo [granule cell](http://purl.obolibrary.org/obo/CL_0000120) and ([has soma location](http://purl.obolibrary.org/obo/RO_0002100) some [dentate gyrus of hippocampal formation](http://purl.obolibrary.org/obo/UBERON_0001885))
+
+#### Added
+- [dentate gyrus of hippocampal formation granule cell](http://purl.obolibrary.org/obo/CL_2000089) [label](http://www.w3.org/2000/01/rdf-schema#label) "dentate gyrus granule cell"
+
+- [dentate gyrus of hippocampal formation granule cell](http://purl.obolibrary.org/obo/CL_2000089) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "dentate gyrus of hippocampal formation granule cell"
+
+- [dentate gyrus of hippocampal formation granule cell](http://purl.obolibrary.org/obo/CL_2000089) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A granule cell that has soma location in the dentate gyrus cell layer of the hippocampal formation and has an elliptical cell body and characteristic cone-shaped tree of spiny apical dendrites. The branches extend throughout the molecular layer and the distal tips of the dendritic tree end just at the hippocampal fissure or at the ventricular surface. The dentate gyrus granule cell is the principal cell type of the dentate gyrus."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:17765709"
+
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie"
+
+- [dentate gyrus of hippocampal formation granule cell](http://purl.obolibrary.org/obo/CL_2000089) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "As far as can be determined, all dentate granule cells appear to project to CA3 and the axon trajectory is partially correlated with the position of the parent cell body."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:17765709"
+
+- [dentate gyrus of hippocampal formation granule cell](http://purl.obolibrary.org/obo/CL_2000089) EquivalentTo [hippocampal granule cell](http://purl.obolibrary.org/obo/CL_0001033) and ([has soma location](http://purl.obolibrary.org/obo/RO_0002100) some [dentate gyrus granule cell layer](http://purl.obolibrary.org/obo/UBERON_0005381))
+
+- [dentate gyrus of hippocampal formation granule cell](http://purl.obolibrary.org/obo/CL_2000089) SubClassOf [has soma location](http://purl.obolibrary.org/obo/RO_0002100) some [dentate gyrus granule cell layer](http://purl.obolibrary.org/obo/UBERON_0005381)
+
+
+### dentition `http://purl.obolibrary.org/obo/UBERON_0003672`
+#### Removed
+- [dentition](http://purl.obolibrary.org/obo/UBERON_0003672) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
+
+
+
+### dermal papilla `http://purl.obolibrary.org/obo/UBERON_0000412`
+#### Removed
+- [dermal papilla](http://purl.obolibrary.org/obo/UBERON_0000412) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### dermatome `http://purl.obolibrary.org/obo/UBERON_0004016`
+#### Removed
+- [dermatome](http://purl.obolibrary.org/obo/UBERON_0004016) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### dermomyotome `http://purl.obolibrary.org/obo/UBERON_0004290`
+#### Removed
+- [dermomyotome](http://purl.obolibrary.org/obo/UBERON_0004290) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### descending colon `http://purl.obolibrary.org/obo/UBERON_0001158`
+#### Removed
+- [descending colon](http://purl.obolibrary.org/obo/UBERON_0001158) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### developmentally induced by `http://purl.obolibrary.org/obo/RO_0002256`
+#### Removed
+- [developmentally induced by](http://purl.obolibrary.org/obo/RO_0002256) Domain [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
+
+- [developmentally induced by](http://purl.obolibrary.org/obo/RO_0002256) Range [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
+
+#### Added
+- [developmentally induced by](http://purl.obolibrary.org/obo/RO_0002256) Domain [material anatomical entity](http://purl.obolibrary.org/obo/UBERON_0000465)
+
+- [developmentally induced by](http://purl.obolibrary.org/obo/RO_0002256) Range [material anatomical entity](http://purl.obolibrary.org/obo/UBERON_0000465)
+
+
+### develops in `http://purl.obolibrary.org/obo/RO_0002226`
+#### Removed
+- [develops in](http://purl.obolibrary.org/obo/RO_0002226) Domain [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+#### Added
+- [develops in](http://purl.obolibrary.org/obo/RO_0002226) Domain [anatomical entity](http://purl.obolibrary.org/obo/UBERON_0001062)
+
+
+### differentiated genital tubercle `http://purl.obolibrary.org/obo/UBERON_0011757`
+#### Removed
+- [differentiated genital tubercle](http://purl.obolibrary.org/obo/UBERON_0011757) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### digestive tract `http://purl.obolibrary.org/obo/UBERON_0001555`
+#### Removed
+- [digestive tract](http://purl.obolibrary.org/obo/UBERON_0001555) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### digit plus metapodial segment `http://purl.obolibrary.org/obo/UBERON_5002544`
+#### Removed
+- [digit plus metapodial segment](http://purl.obolibrary.org/obo/UBERON_5002544) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000)
+
+
+
+### digitopodium region `http://purl.obolibrary.org/obo/UBERON_0012140`
+#### Removed
+- [digitopodium region](http://purl.obolibrary.org/obo/UBERON_0012140) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000)
+
+
+
+### dilatator pupillae `http://purl.obolibrary.org/obo/UBERON_0001608`
+#### Removed
+- [dilatator pupillae](http://purl.obolibrary.org/obo/UBERON_0001608) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000)
+
+
+
+### directly develops from `http://purl.obolibrary.org/obo/RO_0002207`
+#### Removed
+- [directly develops from](http://purl.obolibrary.org/obo/RO_0002207) Domain [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000) or [cell](http://purl.obolibrary.org/obo/CL_0000000)
+
+- [directly develops from](http://purl.obolibrary.org/obo/RO_0002207) Range [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000) or [cell](http://purl.obolibrary.org/obo/CL_0000000)
+
+#### Added
+- [directly develops from](http://purl.obolibrary.org/obo/RO_0002207) Domain [cell](http://purl.obolibrary.org/obo/CL_0000000) or [multicellular anatomical structure](http://purl.obolibrary.org/obo/UBERON_0010000)
+
+- [directly develops from](http://purl.obolibrary.org/obo/RO_0002207) Range [cell](http://purl.obolibrary.org/obo/CL_0000000) or [multicellular anatomical structure](http://purl.obolibrary.org/obo/UBERON_0010000)
+
+
+### directly negatively regulated by `http://purl.obolibrary.org/obo/RO_0002023`
+#### Removed
+- [directly negatively regulated by](http://purl.obolibrary.org/obo/RO_0002023) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "dos"
+
+- [directly negatively regulated by](http://purl.obolibrary.org/obo/RO_0002023) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Process(P2) is directly negatively regulated by process(P1) iff: P1 negatively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding negatively regulates the kinase activity (P2) of protein B then P2 directly negatively regulated by P1."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dos"
+
+#### Added
+- [directly negatively regulated by](http://purl.obolibrary.org/obo/RO_0002023) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) [0000-0002-7073-9172](https://orcid.org/0000-0002-7073-9172)
+
+- [directly negatively regulated by](http://purl.obolibrary.org/obo/RO_0002023) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Process(P2) is directly negatively regulated by process(P1) iff: P1 negatively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding negatively regulates the kinase activity (P2) of protein B then P2 directly negatively regulated by P1."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) [0000-0002-7073-9172](https://orcid.org/0000-0002-7073-9172)
+
+
+### directly negatively regulates `http://purl.obolibrary.org/obo/RO_0002630`
+
+#### Added
+- [directly negatively regulates](http://purl.obolibrary.org/obo/RO_0002630) [see also](http://www.w3.org/2000/01/rdf-schema#seeAlso) "https://wiki.geneontology.org/Directly_negatively_regulates"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI)
+
+
+### directly positively regulated by `http://purl.obolibrary.org/obo/RO_0002024`
+#### Removed
+- [directly positively regulated by](http://purl.obolibrary.org/obo/RO_0002024) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "dos"
+
+- [directly positively regulated by](http://purl.obolibrary.org/obo/RO_0002024) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Process(P2) is directly postively regulated by process(P1) iff: P1 positively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding positively regulates the kinase activity (P2) of protein B then P2 is directly postively regulated by P1."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dos"
+
+#### Added
+- [directly positively regulated by](http://purl.obolibrary.org/obo/RO_0002024) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) [0000-0002-7073-9172](https://orcid.org/0000-0002-7073-9172)
+
+- [directly positively regulated by](http://purl.obolibrary.org/obo/RO_0002024) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Process(P2) is directly postively regulated by process(P1) iff: P1 positively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding positively regulates the kinase activity (P2) of protein B then P2 is directly postively regulated by P1."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) [0000-0002-7073-9172](https://orcid.org/0000-0002-7073-9172)
+
+
+### directly positively regulates `http://purl.obolibrary.org/obo/RO_0002629`
+
+#### Added
+- [directly positively regulates](http://purl.obolibrary.org/obo/RO_0002629) [see also](http://www.w3.org/2000/01/rdf-schema#seeAlso) "https://wiki.geneontology.org/Directly_positively_regulates"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI)
+
+
+### directly regulated by `http://purl.obolibrary.org/obo/RO_0002022`
+#### Removed
+- [directly regulated by](http://purl.obolibrary.org/obo/RO_0002022) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "dos"
+
+- [directly regulated by](http://purl.obolibrary.org/obo/RO_0002022) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "Process(P2) is directly regulated by process(P1) iff: P1 regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding regulates the kinase activity (P2) of protein B then P1 directly regulates P2."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dos"
+
+#### Added
+- [directly regulated by](http://purl.obolibrary.org/obo/RO_0002022) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "Process(P2) is directly regulated by process(P1) iff: P1 regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding regulates the kinase activity (P2) of protein B then P1 directly regulates P2."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) [0000-0002-7073-9172](https://orcid.org/0000-0002-7073-9172)
+
+- [directly regulated by](http://purl.obolibrary.org/obo/RO_0002022) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) [0000-0002-7073-9172](https://orcid.org/0000-0002-7073-9172)
+
+
+### ductal plate `http://purl.obolibrary.org/obo/UBERON_8410003`
+#### Removed
+- [ductal plate](http://purl.obolibrary.org/obo/UBERON_8410003) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### ear hair cell `http://purl.obolibrary.org/obo/CL_0002374`
+#### Removed
+- [ear hair cell](http://purl.obolibrary.org/obo/CL_0002374) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### early T lineage precursor `http://purl.obolibrary.org/obo/CL_0002425`
+#### Removed
+- [early T lineage precursor](http://purl.obolibrary.org/obo/CL_0002425) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
+
+
+
+### early pro-B cell `http://purl.obolibrary.org/obo/CL_0002046`
+#### Removed
+- [early pro-B cell](http://purl.obolibrary.org/obo/CL_0002046) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
+
+
+
+### early telencephalic vesicle `http://purl.obolibrary.org/obo/UBERON_0009676`
+#### Removed
+- [early telencephalic vesicle](http://purl.obolibrary.org/obo/UBERON_0009676) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### eccentric medium spiny neuron `http://purl.obolibrary.org/obo/CL_4030057`
+
+#### Added
+- [eccentric medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030057) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "eccentric MSN"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
+
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1101/2022.10.12.511898"
+
+- [eccentric medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030057) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "The term “eccentric” is used in the name eccentric medium spiny neuron (MSN) due to the exhibited transcriptional divergence from canonical spiny projection neurons. It has been noted in at least one study that an eccentric MSN differs in expression from direct and indirect MSNs by 110 genes (more than the 68 that distinguished direct and indirect spiny projection neurons from each other) and expresses many genes that have little expression in the rest of the striatum. It also has been noted in at least one human study that most eccentric MSNs expressed only DRD1, but many in the basal ganglia co-expressed DRD1 and DRD2, suggesting regional specialization of a more broadly distributed cell type."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/j.cell.2018.07.028"
+
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1101/2022.10.12.511898"
+
+- [eccentric medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030057) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "eccentric SPN"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
+
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/j.cell.2018.07.028"
+
+- [eccentric medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030057) [date](http://purl.org/dc/terms/date) "2023-06-23T14:59:36Z"^^[dateTime](http://www.w3.org/2001/XMLSchema#dateTime)
+
+- [eccentric medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030057) [label](http://www.w3.org/2000/01/rdf-schema#label) "eccentric medium spiny neuron"
+
+- [eccentric medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030057) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A medium spiny neuron that exhibits transcriptional divergence from direct and indirect spiny projection neurons, for example, enrichment in Casz1, Otof, Cacng5 and Pcdh8 noted in mice. Whilst in general medium spiny neurons have been found to be differentially distributed across the basal ganglia, the eccentric medium spiny neuron cell type has been found to be more evenly distributed throughout cerebral nuclei."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/j.cell.2018.07.028"
+
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1101/2022.10.12.511898"
+
+- [eccentric medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030057) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "eSPN"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
+
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/j.cell.2018.07.028"
+
+- [eccentric medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030057) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "eccentric spiny projection neuron"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/j.cell.2018.07.028"
+
+- Class: [eccentric medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030057)
+
+- [eccentric medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030057) SubClassOf [medium spiny neuron](http://purl.obolibrary.org/obo/CL_1001474)
+
+
+### ecto-epithelial cell `http://purl.obolibrary.org/obo/CL_0002077`
+#### Removed
+- [ecto-epithelial cell](http://purl.obolibrary.org/obo/CL_0002077) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### ectoderm-derived structure `http://purl.obolibrary.org/obo/UBERON_0004121`
+#### Removed
+- [ectoderm-derived structure](http://purl.obolibrary.org/obo/UBERON_0004121) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### ectonucleotide pyrophosphatase/phosphodiesterase family member 3 `http://purl.obolibrary.org/obo/PR_000001344`
+
+#### Added
+- [ectonucleotide pyrophosphatase/phosphodiesterase family member 3](http://purl.obolibrary.org/obo/PR_000001344) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [ectonucleotide pyrophosphatase/phosphodiesterase family member 3 (human)](http://purl.obolibrary.org/obo/PR_O14638)
+
+
+### editor note `http://purl.obolibrary.org/obo/IAO_0000116`
+
+#### Added
+- [editor note](http://purl.obolibrary.org/obo/IAO_0000116) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "editor note"@en
+
+- [editor note](http://purl.obolibrary.org/obo/IAO_0000116) [IAO_0000117](http://purl.obolibrary.org/obo/IAO_0000117) "PERSON:Daniel Schober"@en
+
+- [editor note](http://purl.obolibrary.org/obo/IAO_0000116) [IAO_0000119](http://purl.obolibrary.org/obo/IAO_0000119) "GROUP:OBI:<http://purl.obofoundry.org/obo/obi>"@en
+
+- [editor note](http://purl.obolibrary.org/obo/IAO_0000116) [label](http://www.w3.org/2000/01/rdf-schema#label) "editor note"@en
+
+- [editor note](http://purl.obolibrary.org/obo/IAO_0000116) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "An administrative note intended for its editor. It may not be included in the publication version of the ontology, so it should contain nothing necessary for end users to understand the ontology."@en
+
+- [editor note](http://purl.obolibrary.org/obo/IAO_0000116) [IAO_0000114](http://purl.obolibrary.org/obo/IAO_0000114) [ready for release](http://purl.obolibrary.org/obo/IAO_0000122)
+
+- [editor note](http://purl.obolibrary.org/obo/IAO_0000116) [isDefinedBy](http://www.w3.org/2000/01/rdf-schema#isDefinedBy) [iao.owl](http://purl.obolibrary.org/obo/iao.owl)
+
+
+### egg cell `http://purl.obolibrary.org/obo/CL_0000025`
+#### Removed
+- [egg cell](http://purl.obolibrary.org/obo/CL_0000025) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### elbow joint `http://purl.obolibrary.org/obo/UBERON_0001490`
+#### Removed
+- [elbow joint](http://purl.obolibrary.org/obo/UBERON_0001490) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### elbow joint primordium `http://purl.obolibrary.org/obo/UBERON_0006224`
+#### Removed
+- [elbow joint primordium](http://purl.obolibrary.org/obo/UBERON_0006224) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### elicited macrophage `http://purl.obolibrary.org/obo/CL_0000861`
+#### Removed
+- [elicited macrophage](http://purl.obolibrary.org/obo/CL_0000861) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
+
+
+
+### embryonic cloaca `http://purl.obolibrary.org/obo/UBERON_0000163`
+#### Removed
+- [embryonic cloaca](http://purl.obolibrary.org/obo/UBERON_0000163) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### embryonic post-anal tail `http://purl.obolibrary.org/obo/UBERON_0007144`
+#### Removed
+- [embryonic post-anal tail](http://purl.obolibrary.org/obo/UBERON_0007144) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### embryonic skin basal layer `http://purl.obolibrary.org/obo/UBERON_0011272`
+#### Removed
+- [embryonic skin basal layer](http://purl.obolibrary.org/obo/UBERON_0011272) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### embryonic urethral groove `http://purl.obolibrary.org/obo/UBERON_0013241`
+#### Removed
+- [embryonic urethral groove](http://purl.obolibrary.org/obo/UBERON_0013241) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### enabled by `http://purl.obolibrary.org/obo/RO_0002333`
+
+#### Added
+- [enabled by](http://purl.obolibrary.org/obo/RO_0002333) [see also](http://www.w3.org/2000/01/rdf-schema#seeAlso) "https://wiki.geneontology.org/Enabled_by"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI)
+
+
+### enables `http://purl.obolibrary.org/obo/RO_0002327`
+
+#### Added
+- [enables](http://purl.obolibrary.org/obo/RO_0002327) [see also](http://www.w3.org/2000/01/rdf-schema#seeAlso) "https://wiki.geneontology.org/Enables"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI)
+
+
+### endo-epithelial cell `http://purl.obolibrary.org/obo/CL_0002076`
+#### Removed
+- [endo-epithelial cell](http://purl.obolibrary.org/obo/CL_0002076) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### endocardium of left ventricle `http://purl.obolibrary.org/obo/UBERON_0009713`
+#### Removed
+- [endocardium of left ventricle](http://purl.obolibrary.org/obo/UBERON_0009713) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000)
+
+
+
+### endocardium of right ventricle `http://purl.obolibrary.org/obo/UBERON_0009712`
+#### Removed
+- [endocardium of right ventricle](http://purl.obolibrary.org/obo/UBERON_0009712) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000)
+
+
+
+### endoderm-derived structure `http://purl.obolibrary.org/obo/UBERON_0004119`
+#### Removed
+- [endoderm-derived structure](http://purl.obolibrary.org/obo/UBERON_0004119) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### endoglin `http://purl.obolibrary.org/obo/PR_000001345`
+
+#### Added
+- [endoglin](http://purl.obolibrary.org/obo/PR_000001345) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [endoglin (human)](http://purl.obolibrary.org/obo/PR_P17813)
+
+
+### endothelial cell of respiratory system lymphatic vessel `http://purl.obolibrary.org/obo/CL_0009086`
+#### Removed
+- [endothelial cell of respiratory system lymphatic vessel](http://purl.obolibrary.org/obo/CL_0009086) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [respiratory system lymphatic vessel](http://purl.obolibrary.org/obo/UBERON_0003456)
+
+#### Added
+- [endothelial cell of respiratory system lymphatic vessel](http://purl.obolibrary.org/obo/CL_0009086) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [respiratory system lymphatic vessel endothelium](http://purl.obolibrary.org/obo/UBERON_0003529)
+
+
+### endothelial transcription factor GATA-2 `http://purl.obolibrary.org/obo/PR_000007858`
+
+#### Added
+- [endothelial transcription factor GATA-2](http://purl.obolibrary.org/obo/PR_000007858) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [endothelial transcription factor GATA-2 (human)](http://purl.obolibrary.org/obo/PR_P23769)
+
+
+### enteric nervous system `http://purl.obolibrary.org/obo/UBERON_0002005`
+#### Removed
+- [enteric nervous system](http://purl.obolibrary.org/obo/UBERON_0002005) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### entire embryonic mesenchyme `http://purl.obolibrary.org/obo/UBERON_0009142`
+#### Removed
+- [entire embryonic mesenchyme](http://purl.obolibrary.org/obo/UBERON_0009142) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### enveloping layer of ectoderm `http://purl.obolibrary.org/obo/UBERON_0007383`
+#### Removed
+- [enveloping layer of ectoderm](http://purl.obolibrary.org/obo/UBERON_0007383) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### eosinophil cationic protein `http://purl.obolibrary.org/obo/PR_000014047`
+
+#### Added
+- [eosinophil cationic protein](http://purl.obolibrary.org/obo/PR_000014047) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [eosinophil cationic protein (human)](http://purl.obolibrary.org/obo/PR_P12724)
+
+
+### eosinophil peroxidase `http://purl.obolibrary.org/obo/PR_000007152`
+
+#### Added
+- [eosinophil peroxidase](http://purl.obolibrary.org/obo/PR_000007152) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [eosinophil peroxidase (human)](http://purl.obolibrary.org/obo/PR_P11678)
+
+
+### eosinophil progenitor cell `http://purl.obolibrary.org/obo/CL_0000611`
+#### Removed
+- [eosinophil progenitor cell](http://purl.obolibrary.org/obo/CL_0000611) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
+
+
+
+### epicardium `http://purl.obolibrary.org/obo/UBERON_0002348`
+#### Removed
+- [epicardium](http://purl.obolibrary.org/obo/UBERON_0002348) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000)
+
+
+
+### epiphyseal tract `http://purl.obolibrary.org/obo/UBERON_0034714`
+#### Removed
+- [epiphyseal tract](http://purl.obolibrary.org/obo/UBERON_0034714) SubClassOf [neuron projection bundle](http://purl.obolibrary.org/obo/CARO_0001001)
+
+
+
+### epithelial cell of pancreas `http://purl.obolibrary.org/obo/CL_0000083`
+#### Removed
+- [epithelial cell of pancreas](http://purl.obolibrary.org/obo/CL_0000083) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### epithelium of appendix `http://purl.obolibrary.org/obo/UBERON_0009697`
+#### Removed
+- [epithelium of appendix](http://purl.obolibrary.org/obo/UBERON_0009697) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### epithelium of bronchus `http://purl.obolibrary.org/obo/UBERON_0002031`
+#### Removed
+- [epithelium of bronchus](http://purl.obolibrary.org/obo/UBERON_0002031) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### epithelium of carpal region `http://purl.obolibrary.org/obo/UBERON_0003230`
+#### Removed
+- [epithelium of carpal region](http://purl.obolibrary.org/obo/UBERON_0003230) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### epithelium of elbow `http://purl.obolibrary.org/obo/UBERON_0003229`
+#### Removed
+- [epithelium of elbow](http://purl.obolibrary.org/obo/UBERON_0003229) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### epithelium of footplate `http://purl.obolibrary.org/obo/UBERON_0003248`
+#### Removed
+- [epithelium of footplate](http://purl.obolibrary.org/obo/UBERON_0003248) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### epithelium of forearm `http://purl.obolibrary.org/obo/UBERON_0003247`
+#### Removed
+- [epithelium of forearm](http://purl.obolibrary.org/obo/UBERON_0003247) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### epithelium of handplate `http://purl.obolibrary.org/obo/UBERON_0010332`
+#### Removed
+- [epithelium of handplate](http://purl.obolibrary.org/obo/UBERON_0010332) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### epithelium of hip `http://purl.obolibrary.org/obo/UBERON_0003231`
+#### Removed
+- [epithelium of hip](http://purl.obolibrary.org/obo/UBERON_0003231) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### epithelium of knee `http://purl.obolibrary.org/obo/UBERON_0003232`
+#### Removed
+- [epithelium of knee](http://purl.obolibrary.org/obo/UBERON_0003232) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### epithelium of mammary gland `http://purl.obolibrary.org/obo/UBERON_0003244`
+#### Removed
+- [epithelium of mammary gland](http://purl.obolibrary.org/obo/UBERON_0003244) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### epithelium of respiratory bronchiole `http://purl.obolibrary.org/obo/UBERON_0001955`
+#### Removed
+- [epithelium of respiratory bronchiole](http://purl.obolibrary.org/obo/UBERON_0001955) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
+
+
+
+### epithelium of saccule `http://purl.obolibrary.org/obo/UBERON_0003242`
+#### Removed
+- [epithelium of saccule](http://purl.obolibrary.org/obo/UBERON_0003242) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### epithelium of shoulder `http://purl.obolibrary.org/obo/UBERON_0003233`
+#### Removed
+- [epithelium of shoulder](http://purl.obolibrary.org/obo/UBERON_0003233) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### epithelium of utricle `http://purl.obolibrary.org/obo/UBERON_0003241`
+#### Removed
+- [epithelium of utricle](http://purl.obolibrary.org/obo/UBERON_0003241) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### erythroid progenitor cell, mammalian `http://purl.obolibrary.org/obo/CL_0001066`
+#### Removed
+- [erythroid progenitor cell, mammalian](http://purl.obolibrary.org/obo/CL_0001066) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
+
+
+
+### erythroid transcription factor `http://purl.obolibrary.org/obo/PR_000007857`
+
+#### Added
+- [erythroid transcription factor](http://purl.obolibrary.org/obo/PR_000007857) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [erythroid transcription factor (human)](http://purl.obolibrary.org/obo/PR_P15976)
+
+
+### erythrophore `http://purl.obolibrary.org/obo/CL_0000574`
+#### Removed
+- [erythrophore](http://purl.obolibrary.org/obo/CL_0000574) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### ethmoid bone primordium `http://purl.obolibrary.org/obo/UBERON_0006227`
+#### Removed
+- [ethmoid bone primordium](http://purl.obolibrary.org/obo/UBERON_0006227) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### ethmoid region `http://purl.obolibrary.org/obo/UBERON_0011241`
+#### Removed
+- [ethmoid region](http://purl.obolibrary.org/obo/UBERON_0011241) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### example to be eventually removed `http://purl.obolibrary.org/obo/IAO_0000002`
+
+#### Added
+- [example to be eventually removed](http://purl.obolibrary.org/obo/IAO_0000002) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "example to be eventually removed"@en
+
+- [example to be eventually removed](http://purl.obolibrary.org/obo/IAO_0000002) [label](http://www.w3.org/2000/01/rdf-schema#label) "example to be eventually removed"@en
+
+- Individual: [example to be eventually removed](http://purl.obolibrary.org/obo/IAO_0000002)
+
+
+### expand expression to `http://purl.obolibrary.org/obo/IAO_0000424`
+
+#### Added
+- [expand expression to](http://purl.obolibrary.org/obo/IAO_0000424) [IAO_0000112](http://purl.obolibrary.org/obo/IAO_0000112) "ObjectProperty: RO_0002104
+Label: has plasma membrane part
+Annotations: IAO_0000424 "http://purl.obolibrary.org/obo/BFO_0000051 some (http://purl.org/obo/owl/GO#GO_0005886 and http://purl.obolibrary.org/obo/BFO_0000051 some ?Y)"
+"@en
+
+- [expand expression to](http://purl.obolibrary.org/obo/IAO_0000424) [label](http://www.w3.org/2000/01/rdf-schema#label) "expand expression to"@en
+
+- [expand expression to](http://purl.obolibrary.org/obo/IAO_0000424) [IAO_0000117](http://purl.obolibrary.org/obo/IAO_0000117) "Chris Mungall"@en
+
+- [expand expression to](http://purl.obolibrary.org/obo/IAO_0000424) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "expand expression to"@en
+
+- [expand expression to](http://purl.obolibrary.org/obo/IAO_0000424) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A macro expansion tag applied to an object property (or possibly a data property) which can be used by a macro-expansion engine to generate more complex expressions from simpler ones"@en
+
+
+### expressed in `http://purl.obolibrary.org/obo/RO_0002206`
+#### Removed
+- [expressed in](http://purl.obolibrary.org/obo/RO_0002206) Range [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
+
+#### Added
+- [expressed in](http://purl.obolibrary.org/obo/RO_0002206) Range [material anatomical entity](http://purl.obolibrary.org/obo/UBERON_0000465)
+
+
+### expresses `http://purl.obolibrary.org/obo/RO_0002292`
+#### Removed
+- [expresses](http://purl.obolibrary.org/obo/RO_0002292) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Inverse of 'expressed in'"
+
+#### Added
+- [expresses](http://purl.obolibrary.org/obo/RO_0002292) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "y expresses x if and only if there is a gene expression process (GO:0010467) that occurs in y, and one of the following holds: (i) x is a gene, and x is transcribed into a transcript as part of the gene expression process (ii) x is a transcript, and x was transcribed from a gene as part of the gene expression process (iii) x is a mature gene product (protein or RNA), and x was translated or otherwise processed from a transcript that was transcribed as part of the gene expression process."
+
+
+### external acoustic meatus `http://purl.obolibrary.org/obo/UBERON_0001352`
+#### Removed
+- [external acoustic meatus](http://purl.obolibrary.org/obo/UBERON_0001352) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### external soft tissue zone `http://purl.obolibrary.org/obo/UBERON_0034929`
+#### Removed
+- [external soft tissue zone](http://purl.obolibrary.org/obo/UBERON_0034929) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
+
+
+
+### extratelencephalic-projecting glutamatergic cortical neuron `http://purl.obolibrary.org/obo/CL_4023009`
+
+#### Added
+- [extratelencephalic-projecting glutamatergic cortical neuron](http://purl.obolibrary.org/obo/CL_4023009) [symbol](http://purl.obolibrary.org/obo/IAO_0000028) "ET glut"
+
+
+### eye mesenchyme `http://purl.obolibrary.org/obo/UBERON_0003314`
+#### Removed
+- [eye mesenchyme](http://purl.obolibrary.org/obo/UBERON_0003314) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### eye trabecular meshwork `http://purl.obolibrary.org/obo/UBERON_0005969`
+#### Removed
+- [eye trabecular meshwork](http://purl.obolibrary.org/obo/UBERON_0005969) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### eyelid nerve `http://purl.obolibrary.org/obo/UBERON_0003437`
+#### Removed
+- [eyelid nerve](http://purl.obolibrary.org/obo/UBERON_0003437) SubClassOf [neuron projection bundle](http://purl.obolibrary.org/obo/CARO_0001001)
+
+
+
+### fMet-Leu-Phe receptor `http://purl.obolibrary.org/obo/PR_000001580`
+
+#### Added
+- [fMet-Leu-Phe receptor](http://purl.obolibrary.org/obo/PR_000001580) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [fMet-Leu-Phe receptor (human)](http://purl.obolibrary.org/obo/PR_P21462)
+
+
+### face `http://purl.obolibrary.org/obo/UBERON_0001456`
+#### Removed
+- [face](http://purl.obolibrary.org/obo/UBERON_0001456) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### facial nerve `http://purl.obolibrary.org/obo/UBERON_0001647`
+#### Removed
+- [facial nerve](http://purl.obolibrary.org/obo/UBERON_0001647) SubClassOf [neuron projection bundle](http://purl.obolibrary.org/obo/CARO_0001001)
+
+
+
+### facial skeleton `http://purl.obolibrary.org/obo/UBERON_0011156`
+#### Removed
+- [facial skeleton](http://purl.obolibrary.org/obo/UBERON_0011156) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
+
+
+
+### facio-acoustic VII-VIII preganglion complex `http://purl.obolibrary.org/obo/UBERON_0006232`
+#### Removed
+- [facio-acoustic VII-VIII preganglion complex](http://purl.obolibrary.org/obo/UBERON_0006232) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### failed exploratory term `http://purl.obolibrary.org/obo/IAO_0000103`
+
+#### Added
+- [failed exploratory term](http://purl.obolibrary.org/obo/IAO_0000103) [label](http://www.w3.org/2000/01/rdf-schema#label) "failed exploratory term"@en
+
+- [failed exploratory term](http://purl.obolibrary.org/obo/IAO_0000103) [IAO_0000117](http://purl.obolibrary.org/obo/IAO_0000117) "Person:Alan Ruttenberg"@en
+
+- [failed exploratory term](http://purl.obolibrary.org/obo/IAO_0000103) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "failed exploratory term"@en
+
+- [failed exploratory term](http://purl.obolibrary.org/obo/IAO_0000103) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The term was used in an attempt to structure part of the ontology but in retrospect failed to do a good job"@en
+
+- Individual: [failed exploratory term](http://purl.obolibrary.org/obo/IAO_0000103)
+
+
+### fasciculates with `http://purl.obolibrary.org/obo/RO_0002101`
+#### Removed
+- [fasciculates with](http://purl.obolibrary.org/obo/RO_0002101) Range [neuron projection bundle](http://purl.obolibrary.org/obo/CARO_0001001)
+
+#### Added
+- [fasciculates with](http://purl.obolibrary.org/obo/RO_0002101) Range [neuron projection bundle](http://purl.obolibrary.org/obo/UBERON_0000122)
+
+
+### fat cell `http://purl.obolibrary.org/obo/CL_0000136`
+#### Removed
+- [fat cell](http://purl.obolibrary.org/obo/CL_0000136) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### fetal liver hematopoietic progenitor cell `http://purl.obolibrary.org/obo/CL_0002353`
+#### Removed
+- [fetal liver hematopoietic progenitor cell](http://purl.obolibrary.org/obo/CL_0002353) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
+
+
+
+### fibroblast `http://purl.obolibrary.org/obo/CL_0000057`
+#### Removed
+- [fibroblast](http://purl.obolibrary.org/obo/CL_0000057) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### fibroblast growth factor 8 `http://purl.obolibrary.org/obo/PR_000007499`
+
+#### Added
+- [fibroblast growth factor 8](http://purl.obolibrary.org/obo/PR_000007499) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [fibroblast growth factor 8 (human)](http://purl.obolibrary.org/obo/PR_P55075)
+
+
+### follicle cell of egg chamber `http://purl.obolibrary.org/obo/CL_0000477`
+#### Removed
+- [follicle cell of egg chamber](http://purl.obolibrary.org/obo/CL_0000477) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### follicular fluid `http://purl.obolibrary.org/obo/UBERON_0000038`
+#### Removed
+- [follicular fluid](http://purl.obolibrary.org/obo/UBERON_0000038) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### folliculostellate cell `http://purl.obolibrary.org/obo/CL_0000642`
+#### Removed
+- [folliculostellate cell](http://purl.obolibrary.org/obo/CL_0000642) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A supportive cell of the vertebrate pituitary that provides macromolecular transport and secretes hormones."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "JB:jb"
+
+- [folliculostellate cell](http://purl.obolibrary.org/obo/CL_0000642) SubClassOf [endocrine cell](http://purl.obolibrary.org/obo/CL_0000163)
+
+#### Added
+- [folliculostellate cell](http://purl.obolibrary.org/obo/CL_0000642) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "folliculo-stellate cell"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.23937/2572-407X.1510006"
+
+- [folliculostellate cell](http://purl.obolibrary.org/obo/CL_0000642) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "An agranular supporting cell of the anterior pituitary (adenohypophysis) that is characterized by a star-like morphology and ability to form follicles. Folliculostellate cells communicate with each other and with endocrine cells via gap junctions."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:10495875"
+
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:15961560"
+
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.23937/2572-407X.1510006"
+
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "JB:jb"
+
+- [folliculostellate cell](http://purl.obolibrary.org/obo/CL_0000642) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "Folliculostellate cells are a heterogeneous group of cells rather than a single cell type, with different morphology and gene expression profiles. Due to this heterogeneity, it is unclear if different properties that have been attributed to folliculostellate cells (pluripotent, proliferative, phagocytic) are common in all folliculostellate cells or limited to particular subsets."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:31620083"
+
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:34734454"
+
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.23937/2572-407X.1510006"
+
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:18287078"
+
+- [folliculostellate cell](http://purl.obolibrary.org/obo/CL_0000642) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "Sox2-positive stem cell"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:34734454"
+
+- [folliculostellate cell](http://purl.obolibrary.org/obo/CL_0000642) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "FSC"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
+
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.23937/2572-407X.1510006"
+
+- [folliculostellate cell](http://purl.obolibrary.org/obo/CL_0000642) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "pituitary folliculostellate cell"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:34734454"
+
+- [folliculostellate cell](http://purl.obolibrary.org/obo/CL_0000642) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "FS cell"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
+
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:34734454"
+
+- [folliculostellate cell](http://purl.obolibrary.org/obo/CL_0000642) SubClassOf [paracrine cell](http://purl.obolibrary.org/obo/CL_0000512)
+
+- [folliculostellate cell](http://purl.obolibrary.org/obo/CL_0000642) SubClassOf [pituitary gland cell](http://purl.obolibrary.org/obo/CL_2000004)
+
+- [folliculostellate cell](http://purl.obolibrary.org/obo/CL_0000642) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [adenohypophysis](http://purl.obolibrary.org/obo/UBERON_0002196)
+
+
+### folliculostellate cell of pars distalis of adenohypophysis `http://purl.obolibrary.org/obo/CL_0002177`
+#### Removed
+- [folliculostellate cell of pars distalis of adenohypophysis](http://purl.obolibrary.org/obo/CL_0002177) SubClassOf [pituitary gland cell](http://purl.obolibrary.org/obo/CL_2000004)
+
+
+
+### forebrain-midbrain boundary `http://purl.obolibrary.org/obo/UBERON_0005075`
+#### Removed
+- [forebrain-midbrain boundary](http://purl.obolibrary.org/obo/UBERON_0005075) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### forkhead box protein N1 `http://purl.obolibrary.org/obo/PR_000007636`
+
+#### Added
+- [forkhead box protein N1](http://purl.obolibrary.org/obo/PR_000007636) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [forkhead box protein N1 (human)](http://purl.obolibrary.org/obo/PR_O15353)
+
+
+### forkhead box protein P3 `http://purl.obolibrary.org/obo/PR_000001350`
+
+#### Added
+- [forkhead box protein P3](http://purl.obolibrary.org/obo/PR_000001350) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [forkhead box protein P3 (human)](http://purl.obolibrary.org/obo/PR_Q9BZS1)
+
+
+### fourth ventricle `http://purl.obolibrary.org/obo/UBERON_0002422`
+#### Removed
+- [fourth ventricle](http://purl.obolibrary.org/obo/UBERON_0002422) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### fovea centralis `http://purl.obolibrary.org/obo/UBERON_0001786`
+#### Removed
+- [fovea centralis](http://purl.obolibrary.org/obo/UBERON_0001786) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### fraction A pre-pro B cell `http://purl.obolibrary.org/obo/CL_0002045`
+#### Removed
+- [fraction A pre-pro B cell](http://purl.obolibrary.org/obo/CL_0002045) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
+
+
+
+### frontonasal process epithelium `http://purl.obolibrary.org/obo/UBERON_0014702`
+#### Removed
+- [frontonasal process epithelium](http://purl.obolibrary.org/obo/UBERON_0014702) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### fundus of stomach `http://purl.obolibrary.org/obo/UBERON_0001160`
+#### Removed
+- [fundus of stomach](http://purl.obolibrary.org/obo/UBERON_0001160) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
+
+
+
+### fundus of urinary bladder `http://purl.obolibrary.org/obo/UBERON_0006082`
+#### Removed
+- [fundus of urinary bladder](http://purl.obolibrary.org/obo/UBERON_0006082) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### future coelemic cavity lumen `http://purl.obolibrary.org/obo/UBERON_0003886`
+#### Removed
+- [future coelemic cavity lumen](http://purl.obolibrary.org/obo/UBERON_0003886) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### future dermis `http://purl.obolibrary.org/obo/UBERON_0010083`
+#### Removed
+- [future dermis](http://purl.obolibrary.org/obo/UBERON_0010083) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### future diaphragm `http://purl.obolibrary.org/obo/UBERON_0010084`
+#### Removed
+- [future diaphragm](http://purl.obolibrary.org/obo/UBERON_0010084) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
+
+
+
+### future facial nucleus `http://purl.obolibrary.org/obo/UBERON_0010123`
+#### Removed
+- [future facial nucleus](http://purl.obolibrary.org/obo/UBERON_0010123) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### future glans `http://purl.obolibrary.org/obo/UBERON_0013238`
+#### Removed
+- [future glans](http://purl.obolibrary.org/obo/UBERON_0013238) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### future lower lip `http://purl.obolibrary.org/obo/UBERON_0011596`
+#### Removed
+- [future lower lip](http://purl.obolibrary.org/obo/UBERON_0011596) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### future mouth `http://purl.obolibrary.org/obo/UBERON_0035804`
+#### Removed
+- [future mouth](http://purl.obolibrary.org/obo/UBERON_0035804) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### future superior salivatory nucleus `http://purl.obolibrary.org/obo/UBERON_0010125`
+#### Removed
+- [future superior salivatory nucleus](http://purl.obolibrary.org/obo/UBERON_0010125) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### future upper lip `http://purl.obolibrary.org/obo/UBERON_0011592`
+#### Removed
+- [future upper lip](http://purl.obolibrary.org/obo/UBERON_0011592) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### galectin-1 `http://purl.obolibrary.org/obo/PR_000009766`
+
+#### Added
+- [galectin-1](http://purl.obolibrary.org/obo/PR_000009766) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [galectin-1 (human)](http://purl.obolibrary.org/obo/PR_P09382)
+
+
+### gamma-delta T cell `http://purl.obolibrary.org/obo/CL_0000798`
+#### Removed
+- [gamma-delta T cell](http://purl.obolibrary.org/obo/CL_0000798) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
+
+
+
+### gamma-synuclein `http://purl.obolibrary.org/obo/PR_000015325`
+
+#### Added
+- [gamma-synuclein](http://purl.obolibrary.org/obo/PR_000015325) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [gamma-synuclein (human)](http://purl.obolibrary.org/obo/PR_O76070)
+
+
+### ganglion `http://purl.obolibrary.org/obo/UBERON_0000045`
+#### Removed
+- [ganglion](http://purl.obolibrary.org/obo/UBERON_0000045) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### ganglion mother cell `http://purl.obolibrary.org/obo/CL_0000469`
+#### Removed
+- [ganglion mother cell](http://purl.obolibrary.org/obo/CL_0000469) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### ganglionic layer of retina `http://purl.obolibrary.org/obo/UBERON_0001792`
+#### Removed
+- [ganglionic layer of retina](http://purl.obolibrary.org/obo/UBERON_0001792) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### gastrula `http://purl.obolibrary.org/obo/UBERON_0004734`
+#### Removed
+- [gastrula](http://purl.obolibrary.org/obo/UBERON_0004734) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### generically dependent continuant `http://purl.obolibrary.org/obo/BFO_0000031`
+#### Removed
+- [generically dependent continuant](http://purl.obolibrary.org/obo/BFO_0000031) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A continuant that is dependent on one or other independent continuant bearers. For every instance of A requires some instance of (an independent continuant type) B but which instance of B serves can change from time to time."@en
+
+#### Added
+- [generically dependent continuant](http://purl.obolibrary.org/obo/BFO_0000031) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "b is a generically dependent continuant = Def. b is a continuant that g-depends_on one or more other entities. (axiom label in BFO2 Reference: [074-001])"@en
+
+- [generically dependent continuant](http://purl.obolibrary.org/obo/BFO_0000031) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "A continuant that is dependent on one or other independent continuant bearers. For every instance of A requires some instance of (an independent continuant type) B but which instance of B serves can change from time to time."@en
+
+
+### genitourinary system `http://purl.obolibrary.org/obo/UBERON_0004122`
+#### Removed
+- [genitourinary system](http://purl.obolibrary.org/obo/UBERON_0004122) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
+
+
+
+### germ layer / neural crest `http://purl.obolibrary.org/obo/UBERON_0010316`
+#### Removed
+- [germ layer / neural crest](http://purl.obolibrary.org/obo/UBERON_0010316) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### girdle skeleton `http://purl.obolibrary.org/obo/UBERON_0010719`
+#### Removed
+- [girdle skeleton](http://purl.obolibrary.org/obo/UBERON_0010719) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000)
+
+
+
+### glans `http://purl.obolibrary.org/obo/UBERON_0035651`
+#### Removed
+- [glans](http://purl.obolibrary.org/obo/UBERON_0035651) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### glial blood brain barrier `http://purl.obolibrary.org/obo/UBERON_0000202`
+#### Removed
+- [glial blood brain barrier](http://purl.obolibrary.org/obo/UBERON_0000202) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### glial fibrillary acidic protein `http://purl.obolibrary.org/obo/PR_000007939`
+
+#### Added
+- [glial fibrillary acidic protein](http://purl.obolibrary.org/obo/PR_000007939) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [glial fibrillary acidic protein (human)](http://purl.obolibrary.org/obo/PR_P14136)
+
+
+### glioblast `http://purl.obolibrary.org/obo/CL_0000030`
+#### Removed
+- [glioblast](http://purl.obolibrary.org/obo/CL_0000030) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### glomeral mesenchyme `http://purl.obolibrary.org/obo/UBERON_0007128`
+#### Removed
+- [glomeral mesenchyme](http://purl.obolibrary.org/obo/UBERON_0007128) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### glomerular capsule `http://purl.obolibrary.org/obo/UBERON_0001230`
+#### Removed
+- [glomerular capsule](http://purl.obolibrary.org/obo/UBERON_0001230) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### glossopharyngeal nerve `http://purl.obolibrary.org/obo/UBERON_0001649`
+#### Removed
+- [glossopharyngeal nerve](http://purl.obolibrary.org/obo/UBERON_0001649) SubClassOf [neuron projection bundle](http://purl.obolibrary.org/obo/CARO_0001001)
+
+
+
+### glutamate decarboxylase 1 `http://purl.obolibrary.org/obo/PR_000007785`
+
+#### Added
+- [glutamate decarboxylase 1](http://purl.obolibrary.org/obo/PR_000007785) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [glutamate decarboxylase 1 (human)](http://purl.obolibrary.org/obo/PR_Q99259)
+
+
+### glutamyl aminopeptidase `http://purl.obolibrary.org/obo/PR_000002039`
+
+#### Added
+- [glutamyl aminopeptidase](http://purl.obolibrary.org/obo/PR_000002039) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [glutamyl aminopeptidase (human)](http://purl.obolibrary.org/obo/PR_Q07075)
+
+
+### glycophorin-A `http://purl.obolibrary.org/obo/PR_000001460`
+
+#### Added
+- [glycophorin-A](http://purl.obolibrary.org/obo/PR_000001460) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [glycophorin-A (human)](http://purl.obolibrary.org/obo/PR_P02724)
+
+
+### gonad primordium `http://purl.obolibrary.org/obo/UBERON_0005564`
+#### Removed
+- [gonad primordium](http://purl.obolibrary.org/obo/UBERON_0005564) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### gonadal ridge `http://purl.obolibrary.org/obo/UBERON_0005294`
+#### Removed
+- [gonadal ridge](http://purl.obolibrary.org/obo/UBERON_0005294) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### gonadal vein `http://purl.obolibrary.org/obo/UBERON_0003848`
+#### Removed
+- [gonadal vein](http://purl.obolibrary.org/obo/UBERON_0003848) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000)
+
+
+
+### granular layer of cerebellar cortex `http://purl.obolibrary.org/obo/UBERON_0002956`
+#### Removed
+- [granular layer of cerebellar cortex](http://purl.obolibrary.org/obo/UBERON_0002956) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
-- [caudate-putamen](http://purl.obolibrary.org/obo/UBERON_0005383) [UBPROP_0000011](http://purl.obolibrary.org/obo/UBPROP_0000011) "In the human, histologically the caudate nucleus and putamen are identically and share a common embryological origin[ISBN:0123813611]"
-- [caudate-putamen](http://purl.obolibrary.org/obo/UBERON_0005383) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "caudate putamen"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "NLXANAT:100312"
+### granule cell precursor `http://purl.obolibrary.org/obo/CL_0002362`
+#### Removed
+- [granule cell precursor](http://purl.obolibrary.org/obo/CL_0002362) [label](http://www.w3.org/2000/01/rdf-schema#label) "granule cell precursor"
+
+- [granule cell precursor](http://purl.obolibrary.org/obo/CL_0002362) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A cell located in the outermost proliferative zone of the external germinal layer that can differentiate into astroglial cells and granule cells. This cell type is glial fibrillary acidic protein-positive and NK1-positive."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:tfm"
+
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:14745007"
-- [caudate-putamen](http://purl.obolibrary.org/obo/UBERON_0005383) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "caudoputamen"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "NLXANAT:100312"
+#### Added
+- [granule cell precursor](http://purl.obolibrary.org/obo/CL_0002362) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A cell located in the outermost proliferative zone of the external germinal layer that can differentiate into astroglial cells and granule cells. This cell type is glial fibrillary acidic protein-positive and HNK1-positive."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:tfm"
-- [caudate-putamen](http://purl.obolibrary.org/obo/UBERON_0005383) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "uberon"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:14745007"
+
+- [granule cell precursor](http://purl.obolibrary.org/obo/CL_0002362) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "GCP"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
-- [caudate-putamen](http://purl.obolibrary.org/obo/UBERON_0005383) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "dorsal striatum"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "NLXANAT:100312"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.3389/fncir.2020.611841"
-- [caudate-putamen](http://purl.obolibrary.org/obo/UBERON_0005383) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "caudate-putamen"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "NLXANAT:100312"
+- [granule cell precursor](http://purl.obolibrary.org/obo/CL_0002362) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "granule cell precursor"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.3389/fncir.2020.611841"
-- [caudate-putamen](http://purl.obolibrary.org/obo/UBERON_0005383) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "neostriatum"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "NLXANAT:100312"
+- [granule cell precursor](http://purl.obolibrary.org/obo/CL_0002362) [label](http://www.w3.org/2000/01/rdf-schema#label) "cerebellar granule cell precursor"
-- [caudate-putamen](http://purl.obolibrary.org/obo/UBERON_0005383) [editor note](http://purl.obolibrary.org/obo/IAO_0000116) "we do not currently place rodent-specific taxon constraints here as this would cause taxon violations. There is an argument for merging this into dorsal striatum and treating the distinction as phenotypic"
+- [granule cell precursor](http://purl.obolibrary.org/obo/CL_0002362) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "granule cell progenitor"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.3389/fncir.2020.611841"
-- [caudate-putamen](http://purl.obolibrary.org/obo/UBERON_0005383) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "caudateputamen"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "NLXANAT:100312"
+- [granule cell precursor](http://purl.obolibrary.org/obo/CL_0002362) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [upper rhombic lip](http://purl.obolibrary.org/obo/UBERON_0009841)
-- [caudate-putamen](http://purl.obolibrary.org/obo/UBERON_0005383) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "BAMS:CPu"
+- [granule cell precursor](http://purl.obolibrary.org/obo/CL_0002362) SubClassOf [neural cell](http://purl.obolibrary.org/obo/CL_0002319)
-- [caudate-putamen](http://purl.obolibrary.org/obo/UBERON_0005383) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "striatum"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "NLXANAT:100312"
-- [caudate-putamen](http://purl.obolibrary.org/obo/UBERON_0005383) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "BM:Tel-C-Pu"
+### granulocyte `http://purl.obolibrary.org/obo/CL_0000094`
+#### Removed
+- [granulocyte](http://purl.obolibrary.org/obo/CL_0000094) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-- Class: [caudate-putamen](http://purl.obolibrary.org/obo/UBERON_0005383)
-- [caudate-putamen](http://purl.obolibrary.org/obo/UBERON_0005383) SubClassOf [central nervous system cell part cluster](http://purl.obolibrary.org/obo/UBERON_0011215)
-- [caudate-putamen](http://purl.obolibrary.org/obo/UBERON_0005383) SubClassOf [has part](http://purl.obolibrary.org/obo/BFO_0000051) some [putamen](http://purl.obolibrary.org/obo/UBERON_0001874)
+### granulocyte monocyte progenitor cell `http://purl.obolibrary.org/obo/CL_0000557`
+#### Removed
+- [granulocyte monocyte progenitor cell](http://purl.obolibrary.org/obo/CL_0000557) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-- [caudate-putamen](http://purl.obolibrary.org/obo/UBERON_0005383) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [dorsal striatum](http://purl.obolibrary.org/obo/UBERON_0005382)
- - [source](http://www.geneontology.org/formats/oboInOwl#source) "MA"
-- [caudate-putamen](http://purl.obolibrary.org/obo/UBERON_0005383) SubClassOf [composed primarily of](http://purl.obolibrary.org/obo/RO_0002473) some [gray matter](http://purl.obolibrary.org/obo/UBERON_0002020)
-- [caudate-putamen](http://purl.obolibrary.org/obo/UBERON_0005383) SubClassOf [contributes to morphology of](http://purl.obolibrary.org/obo/RO_0002433) some [striatum](http://purl.obolibrary.org/obo/UBERON_0002435)
+### granulosa cell layer `http://purl.obolibrary.org/obo/UBERON_0005170`
+#### Removed
+- [granulosa cell layer](http://purl.obolibrary.org/obo/UBERON_0005170) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [caudate-putamen](http://purl.obolibrary.org/obo/UBERON_0005383) SubClassOf [has part](http://purl.obolibrary.org/obo/BFO_0000051) some [caudate nucleus](http://purl.obolibrary.org/obo/UBERON_0001873)
-### cell activation `http://purl.obolibrary.org/obo/GO_0001775`
+### granzyme B `http://purl.obolibrary.org/obo/PR_000003499`
#### Added
-- [cell activation](http://purl.obolibrary.org/obo/GO_0001775) SubClassOf [only in taxon](http://purl.obolibrary.org/obo/RO_0002160) some [Metazoa](http://purl.obolibrary.org/obo/NCBITaxon_33208)
+- [granzyme B](http://purl.obolibrary.org/obo/PR_000003499) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [granzyme B (human)](http://purl.obolibrary.org/obo/PR_P10144)
+
-- [cell activation](http://purl.obolibrary.org/obo/GO_0001775) SubClassOf [in taxon](http://purl.obolibrary.org/obo/RO_0002162) only [Metazoa](http://purl.obolibrary.org/obo/NCBITaxon_33208)
+### group 2 innate lymphoid cell, human `http://purl.obolibrary.org/obo/CL_0001081`
+#### Removed
+- [group 2 innate lymphoid cell, human](http://purl.obolibrary.org/obo/CL_0001081) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-### cell migration `http://purl.obolibrary.org/obo/GO_0016477`
-#### Added
-- [cell migration](http://purl.obolibrary.org/obo/GO_0016477) [never in taxon](http://purl.obolibrary.org/obo/RO_0002161) [Ascomycota](http://purl.obolibrary.org/obo/NCBITaxon_4890)
+### group 2 innate lymphoid cell, mouse `http://purl.obolibrary.org/obo/CL_0002089`
+#### Removed
+- [group 2 innate lymphoid cell, mouse](http://purl.obolibrary.org/obo/CL_0002089) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
+
+
+
+### group 3 innate lymphoid cell, human `http://purl.obolibrary.org/obo/CL_0001078`
+#### Removed
+- [group 3 innate lymphoid cell, human](http://purl.obolibrary.org/obo/CL_0001078) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
+
+
+
+### gustatory papilla of tongue `http://purl.obolibrary.org/obo/UBERON_0014389`
+#### Removed
+- [gustatory papilla of tongue](http://purl.obolibrary.org/obo/UBERON_0014389) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
+
+
+
+### hair follicle matrix region `http://purl.obolibrary.org/obo/UBERON_0006004`
+#### Removed
+- [hair follicle matrix region](http://purl.obolibrary.org/obo/UBERON_0006004) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
+
+
+
+### hair inner root sheath `http://purl.obolibrary.org/obo/UBERON_0005941`
+#### Removed
+- [hair inner root sheath](http://purl.obolibrary.org/obo/UBERON_0005941) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
-- [cell migration](http://purl.obolibrary.org/obo/GO_0016477) DisjointWith [in taxon](http://purl.obolibrary.org/obo/RO_0002162) some [Ascomycota](http://purl.obolibrary.org/obo/NCBITaxon_4890)
-- [cell migration](http://purl.obolibrary.org/obo/GO_0016477) SubClassOf [in taxon](http://purl.obolibrary.org/obo/RO_0002162) some (not ([Ascomycota](http://purl.obolibrary.org/obo/NCBITaxon_4890)))
+### has component activity `http://purl.obolibrary.org/obo/RO_0002017`
+#### Removed
+- [has component activity](http://purl.obolibrary.org/obo/RO_0002017) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "dos"
-- [cell migration](http://purl.obolibrary.org/obo/GO_0016477) SubClassOf not ([in taxon](http://purl.obolibrary.org/obo/RO_0002162) some [Ascomycota](http://purl.obolibrary.org/obo/NCBITaxon_4890))
+#### Added
+- [has component activity](http://purl.obolibrary.org/obo/RO_0002017) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) [0000-0002-7073-9172](https://orcid.org/0000-0002-7073-9172)
-### cell of skeletal muscle `http://purl.obolibrary.org/obo/CL_0000188`
+### has component process `http://purl.obolibrary.org/obo/RO_0002018`
+#### Removed
+- [has component process](http://purl.obolibrary.org/obo/RO_0002018) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "dos"
#### Added
-- [cell of skeletal muscle](http://purl.obolibrary.org/obo/CL_0000188) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [general_cell_types_upper_slim](http://purl.obolibrary.org/obo/cl#general_cell_types_upper_slim)
+- [has component process](http://purl.obolibrary.org/obo/RO_0002018) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) [0000-0002-7073-9172](https://orcid.org/0000-0002-7073-9172)
-### cellular component morphogenesis `http://purl.obolibrary.org/obo/GO_0032989`
+### has developmental contribution from `http://purl.obolibrary.org/obo/RO_0002254`
#### Removed
-- [cellular component morphogenesis](http://purl.obolibrary.org/obo/GO_0032989) SubClassOf [cellular component organization](http://purl.obolibrary.org/obo/GO_0016043)
+- [has developmental contribution from](http://purl.obolibrary.org/obo/RO_0002254) Domain [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [cellular component morphogenesis](http://purl.obolibrary.org/obo/GO_0032989) SubClassOf [cellular developmental process](http://purl.obolibrary.org/obo/GO_0048869)
+- [has developmental contribution from](http://purl.obolibrary.org/obo/RO_0002254) Range [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
#### Added
-- [cellular component morphogenesis](http://purl.obolibrary.org/obo/GO_0032989) [term tracker item](http://purl.obolibrary.org/obo/IAO_0000233) "https://github.com/geneontology/go-ontology/issues/25496"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI)
+- [has developmental contribution from](http://purl.obolibrary.org/obo/RO_0002254) Domain [anatomical entity](http://purl.obolibrary.org/obo/UBERON_0001062)
+
+- [has developmental contribution from](http://purl.obolibrary.org/obo/RO_0002254) Range [anatomical entity](http://purl.obolibrary.org/obo/UBERON_0001062)
-### cellular response to ATP `http://purl.obolibrary.org/obo/GO_0071318`
+### has developmental potential involving `http://purl.obolibrary.org/obo/RO_0002384`
+#### Removed
+- [has developmental potential involving](http://purl.obolibrary.org/obo/RO_0002384) Domain [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+- [has developmental potential involving](http://purl.obolibrary.org/obo/RO_0002384) Range [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
#### Added
-- [cellular response to ATP](http://purl.obolibrary.org/obo/GO_0071318) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "mah"
+- [has developmental potential involving](http://purl.obolibrary.org/obo/RO_0002384) Domain [anatomical entity](http://purl.obolibrary.org/obo/UBERON_0001062)
-- [cellular response to ATP](http://purl.obolibrary.org/obo/GO_0071318) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2009-12-10T05:09:47Z"
+- [has developmental potential involving](http://purl.obolibrary.org/obo/RO_0002384) Range [anatomical entity](http://purl.obolibrary.org/obo/UBERON_0001062)
-- [cellular response to ATP](http://purl.obolibrary.org/obo/GO_0071318) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "cellular response to adenosine 5'-triphosphate"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:mah"
-- [cellular response to ATP](http://purl.obolibrary.org/obo/GO_0071318) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ATP (adenosine 5'-triphosphate) stimulus."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:mah"
+### has effector activity `http://purl.obolibrary.org/obo/RO_0002025`
+#### Removed
+- [has effector activity](http://purl.obolibrary.org/obo/RO_0002025) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A 'has effector activity' B if A and B are GO molecular functions (GO_0003674), A 'has component activity' B and B is the effector (output function) of B. Each compound function has only one effector activity."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dos"
+
+- [has effector activity](http://purl.obolibrary.org/obo/RO_0002025) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "dos"
-- [cellular response to ATP](http://purl.obolibrary.org/obo/GO_0071318) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process"
+#### Added
+- [has effector activity](http://purl.obolibrary.org/obo/RO_0002025) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) [0000-0002-7073-9172](https://orcid.org/0000-0002-7073-9172)
-- [cellular response to ATP](http://purl.obolibrary.org/obo/GO_0071318) [label](http://www.w3.org/2000/01/rdf-schema#label) "cellular response to ATP"
+- [has effector activity](http://purl.obolibrary.org/obo/RO_0002025) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A 'has effector activity' B if A and B are GO molecular functions (GO_0003674), A 'has component activity' B and B is the effector (output function) of B. Each compound function has only one effector activity."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) [0000-0002-7073-9172](https://orcid.org/0000-0002-7073-9172)
-- [cellular response to ATP](http://purl.obolibrary.org/obo/GO_0071318) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0071318"
-- [cellular response to ATP](http://purl.obolibrary.org/obo/GO_0071318) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "cellular response to adenosine triphosphate"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:mah"
+### has fasciculating neuron projection `http://purl.obolibrary.org/obo/RO_0002132`
+#### Removed
+- [has fasciculating neuron projection](http://purl.obolibrary.org/obo/RO_0002132) Domain [neuron projection bundle](http://purl.obolibrary.org/obo/CARO_0001001)
+
+#### Added
+- [has fasciculating neuron projection](http://purl.obolibrary.org/obo/RO_0002132) Domain [neuron projection bundle](http://purl.obolibrary.org/obo/UBERON_0000122)
+
-- Class: [cellular response to ATP](http://purl.obolibrary.org/obo/GO_0071318)
+### has high plasma membrane amount `http://purl.obolibrary.org/obo/RO_0015015`
+#### Removed
+- [has high plasma membrane amount](http://purl.obolibrary.org/obo/RO_0015015) [contributor](http://purl.org/dc/terms/contributor) [0000-0003-1940-6740](http://orcid.org/0000-0003-1940-6740)
-- [cellular response to ATP](http://purl.obolibrary.org/obo/GO_0071318) EquivalentTo [cellular response to chemical stimulus](http://purl.obolibrary.org/obo/GO_0070887) and ([has input](http://purl.obolibrary.org/obo/RO_0002233) some [CHEBI_30616](http://purl.obolibrary.org/obo/CHEBI_30616))
+- [has high plasma membrane amount](http://purl.obolibrary.org/obo/RO_0015015) [contributor](http://purl.org/dc/terms/contributor) [0000-0003-1617-8244](http://orcid.org/0000-0003-1617-8244)
-- [cellular response to ATP](http://purl.obolibrary.org/obo/GO_0071318) SubClassOf [response to ATP](http://purl.obolibrary.org/obo/GO_0033198)
+#### Added
+- [has high plasma membrane amount](http://purl.obolibrary.org/obo/RO_0015015) [contributor](http://purl.org/dc/terms/contributor) [0000-0003-1940-6740](https://orcid.org/0000-0003-1940-6740)
-- [cellular response to ATP](http://purl.obolibrary.org/obo/GO_0071318) SubClassOf [cellular response to chemical stimulus](http://purl.obolibrary.org/obo/GO_0070887)
+- [has high plasma membrane amount](http://purl.obolibrary.org/obo/RO_0015015) [contributor](http://purl.org/dc/terms/contributor) [0000-0003-1617-8244](https://orcid.org/0000-0003-1617-8244)
-### central nervous system myelin formation `http://purl.obolibrary.org/obo/GO_0032289`
+### has input `http://purl.obolibrary.org/obo/RO_0002233`
#### Added
-- [central nervous system myelin formation](http://purl.obolibrary.org/obo/GO_0032289) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "central nervous system myelin sheath formation"
+- [has input](http://purl.obolibrary.org/obo/RO_0002233) [see also](http://www.w3.org/2000/01/rdf-schema#seeAlso) "https://wiki.geneontology.org/Has_input"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI)
-### chemoarchitectural part of brain `http://purl.obolibrary.org/obo/UBERON_0024090`
+### has low plasma membrane amount `http://purl.obolibrary.org/obo/RO_0015016`
+#### Removed
+- [has low plasma membrane amount](http://purl.obolibrary.org/obo/RO_0015016) [contributor](http://purl.org/dc/terms/contributor) [0000-0003-1617-8244](http://orcid.org/0000-0003-1617-8244)
+
+- [has low plasma membrane amount](http://purl.obolibrary.org/obo/RO_0015016) [contributor](http://purl.org/dc/terms/contributor) [0000-0003-1940-6740](http://orcid.org/0000-0003-1940-6740)
#### Added
-- [chemoarchitectural part of brain](http://purl.obolibrary.org/obo/UBERON_0024090) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Regional part of an anatomical region that is revealed by the use of a stain that reveals chemoarchitecture."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "NLXANAT:20090501"
+- [has low plasma membrane amount](http://purl.obolibrary.org/obo/RO_0015016) [contributor](http://purl.org/dc/terms/contributor) [0000-0003-1617-8244](https://orcid.org/0000-0003-1617-8244)
-- [chemoarchitectural part of brain](http://purl.obolibrary.org/obo/UBERON_0024090) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "uberon"
+- [has low plasma membrane amount](http://purl.obolibrary.org/obo/RO_0015016) [contributor](http://purl.org/dc/terms/contributor) [0000-0003-1940-6740](https://orcid.org/0000-0003-1940-6740)
-- [chemoarchitectural part of brain](http://purl.obolibrary.org/obo/UBERON_0024090) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "NLXANAT:20090501"
-- [chemoarchitectural part of brain](http://purl.obolibrary.org/obo/UBERON_0024090) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "chemoarchitectural part"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "NLXANAT:20090501"
+### has muscle insertion `http://purl.obolibrary.org/obo/RO_0002373`
+#### Removed
+- [has muscle insertion](http://purl.obolibrary.org/obo/RO_0002373) Domain [connected anatomical structure](http://purl.obolibrary.org/obo/CARO_0000003)
+ - [editor note](http://purl.obolibrary.org/obo/IAO_0000116) "We need to import uberon muscle into RO to use as a stricter domain constraint"
-- [chemoarchitectural part of brain](http://purl.obolibrary.org/obo/UBERON_0024090) [id](http://www.geneontology.org/formats/oboInOwl#id) "UBERON:0024090"
+#### Added
+- [has muscle insertion](http://purl.obolibrary.org/obo/RO_0002373) Domain [anatomical structure](http://purl.obolibrary.org/obo/UBERON_0000061)
+ - [editor note](http://purl.obolibrary.org/obo/IAO_0000116) "We need to import uberon muscle into RO to use as a stricter domain constraint"
-- [chemoarchitectural part of brain](http://purl.obolibrary.org/obo/UBERON_0024090) [label](http://www.w3.org/2000/01/rdf-schema#label) "chemoarchitectural part of brain"
-- Class: [chemoarchitectural part of brain](http://purl.obolibrary.org/obo/UBERON_0024090)
+### has muscle origin `http://purl.obolibrary.org/obo/RO_0002372`
+#### Removed
+- [has muscle origin](http://purl.obolibrary.org/obo/RO_0002372) Domain [connected anatomical structure](http://purl.obolibrary.org/obo/CARO_0000003)
+ - [comment](http://www.w3.org/2000/01/rdf-schema#comment) "We need to import uberon muscle to create a stricter domain constraint"
-- [chemoarchitectural part of brain](http://purl.obolibrary.org/obo/UBERON_0024090) SubClassOf [regional part of brain](http://purl.obolibrary.org/obo/UBERON_0002616)
+#### Added
+- [has muscle origin](http://purl.obolibrary.org/obo/RO_0002372) Domain [anatomical structure](http://purl.obolibrary.org/obo/UBERON_0000061)
+ - [comment](http://www.w3.org/2000/01/rdf-schema#comment) "We need to import uberon muscle to create a stricter domain constraint"
-### chemoarchitectural part of striatum `http://purl.obolibrary.org/obo/UBERON_0025736`
+### has negative regulatory component activity `http://purl.obolibrary.org/obo/RO_0002014`
+#### Removed
+- [has negative regulatory component activity](http://purl.obolibrary.org/obo/RO_0002014) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "dos"
#### Added
-- [chemoarchitectural part of striatum](http://purl.obolibrary.org/obo/UBERON_0025736) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "uberon"
+- [has negative regulatory component activity](http://purl.obolibrary.org/obo/RO_0002014) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) [0000-0002-7073-9172](https://orcid.org/0000-0002-7073-9172)
-- [chemoarchitectural part of striatum](http://purl.obolibrary.org/obo/UBERON_0025736) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "chemoarchitectural part of neostriatum"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "NLXANAT:20090502"
-- [chemoarchitectural part of striatum](http://purl.obolibrary.org/obo/UBERON_0025736) [id](http://www.geneontology.org/formats/oboInOwl#id) "UBERON:0025736"
+### has obsolescence reason `http://purl.obolibrary.org/obo/IAO_0000231`
-- [chemoarchitectural part of striatum](http://purl.obolibrary.org/obo/UBERON_0025736) [label](http://www.w3.org/2000/01/rdf-schema#label) "chemoarchitectural part of striatum"
+#### Added
+- [has obsolescence reason](http://purl.obolibrary.org/obo/IAO_0000231) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "has obsolescence reason"@en
-- [chemoarchitectural part of striatum](http://purl.obolibrary.org/obo/UBERON_0025736) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "NLXANAT:20090502"
+- [has obsolescence reason](http://purl.obolibrary.org/obo/IAO_0000231) [label](http://www.w3.org/2000/01/rdf-schema#label) "has obsolescence reason"@en
-- Class: [chemoarchitectural part of striatum](http://purl.obolibrary.org/obo/UBERON_0025736)
+- [has obsolescence reason](http://purl.obolibrary.org/obo/IAO_0000231) [IAO_0000117](http://purl.obolibrary.org/obo/IAO_0000117) "PERSON:Alan Ruttenberg"@en
-- [chemoarchitectural part of striatum](http://purl.obolibrary.org/obo/UBERON_0025736) EquivalentTo [chemoarchitectural part of brain](http://purl.obolibrary.org/obo/UBERON_0024090) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [striatum](http://purl.obolibrary.org/obo/UBERON_0002435))
+- [has obsolescence reason](http://purl.obolibrary.org/obo/IAO_0000231) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Relates an annotation property to an obsolescence reason. The values of obsolescence reasons come from a list of predefined terms, instances of the class obsolescence reason specification."@en
-- [chemoarchitectural part of striatum](http://purl.obolibrary.org/obo/UBERON_0025736) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [striatum](http://purl.obolibrary.org/obo/UBERON_0002435)
+- [has obsolescence reason](http://purl.obolibrary.org/obo/IAO_0000231) [IAO_0000117](http://purl.obolibrary.org/obo/IAO_0000117) "PERSON:Melanie Courtot"@en
-- [chemoarchitectural part of striatum](http://purl.obolibrary.org/obo/UBERON_0025736) SubClassOf [chemoarchitectural part of brain](http://purl.obolibrary.org/obo/UBERON_0024090)
+### has output `http://purl.obolibrary.org/obo/RO_0002234`
-### club cell `http://purl.obolibrary.org/obo/CL_0000158`
+#### Added
+- [has output](http://purl.obolibrary.org/obo/RO_0002234) [see also](http://www.w3.org/2000/01/rdf-schema#seeAlso) "https://wiki.geneontology.org/Has_output"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI)
+
+
+### has plasma membrane part `http://purl.obolibrary.org/obo/RO_0002104`
#### Removed
-- [club cell](http://purl.obolibrary.org/obo/CL_0000158) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A non-mucous, epithelial secretory cell that is part of the tracheobronchial tree. A club cell has short microvilli but no cilia. A club cell is able to multiply and differentiate into ciliated cells to regenerate the bronchiolar epithelium and it also protects the tracheobronchial epithelium."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:tfm"
+- [has plasma membrane part](http://purl.obolibrary.org/obo/RO_0002104) Domain [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "DOI:https://doi.org/10.1378/chest.12-2762"
+- [has plasma membrane part](http://purl.obolibrary.org/obo/RO_0002104) Range [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "DOI:10.1183/09031936.00146609"
+#### Added
+- [has plasma membrane part](http://purl.obolibrary.org/obo/RO_0002104) Domain [material anatomical entity](http://purl.obolibrary.org/obo/UBERON_0000465)
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:28128362"
+- [has plasma membrane part](http://purl.obolibrary.org/obo/RO_0002104) Range [material anatomical entity](http://purl.obolibrary.org/obo/UBERON_0000465)
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:29874100"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:7905712"
+### has positive regulatory component activity `http://purl.obolibrary.org/obo/RO_0002015`
+#### Removed
+- [has positive regulatory component activity](http://purl.obolibrary.org/obo/RO_0002015) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "dos"
#### Added
-- [club cell](http://purl.obolibrary.org/obo/CL_0000158) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A non-mucous, epithelial secretory cell that is part of the tracheobronchial tree. A club cell has short microvilli but no cilia. A club cell is able to multiply and differentiate into ciliated cells to regenerate the bronchiolar epithelium and it also protects the tracheobronchial epithelium."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:tfm"
+- [has positive regulatory component activity](http://purl.obolibrary.org/obo/RO_0002015) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) [0000-0002-7073-9172](https://orcid.org/0000-0002-7073-9172)
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "DOI:10.1378/chest.12-2762"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "DOI:10.1183/09031936.00146609"
+### has primary input `http://purl.obolibrary.org/obo/RO_0004009`
+#### Removed
+- [has primary input](http://purl.obolibrary.org/obo/RO_0004009) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "p has primary input c if (a) p has input c and (b) the goal of process is to modify, consume, or transform c."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dph"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:28128362"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:cjm"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:29874100"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:kva"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:7905712"
+ - [comment](http://www.w3.org/2000/01/rdf-schema#comment) "PMID:27812932"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:pt"
-### cumulus cell differentiation `http://purl.obolibrary.org/obo/GO_0001549`
-#### Removed
-- [cumulus cell differentiation](http://purl.obolibrary.org/obo/GO_0001549) SubClassOf [ovulation cycle process](http://purl.obolibrary.org/obo/GO_0022602)
+#### Added
+- [has primary input](http://purl.obolibrary.org/obo/RO_0004009) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "p has primary input c if (a) p has input c and (b) the goal of process is to modify, consume, or transform c."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dph"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) [0000-0002-6601-2165](https://orcid.org/0000-0002-6601-2165)
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:kva"
-### cysteine-type peptidase activity `http://purl.obolibrary.org/obo/GO_0008234`
+ - [comment](http://www.w3.org/2000/01/rdf-schema#comment) "PMID:27812932"
+
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:pt"
+
+
+### has primary output `http://purl.obolibrary.org/obo/RO_0004008`
#### Removed
-- [cysteine-type peptidase activity](http://purl.obolibrary.org/obo/GO_0008234) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-9757951"
- - [label](http://www.w3.org/2000/01/rdf-schema#label) "CASP8 cleaves N4BP1 at D424, D490"
+- [has primary output](http://purl.obolibrary.org/obo/RO_0004008) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "p has primary output c if (a) p has output c and (b) the goal of process is to modify, produce, or transform c."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dph"
-- [cysteine-type peptidase activity](http://purl.obolibrary.org/obo/GO_0008234) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "thiol protease activity"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:cjm"
-- [cysteine-type peptidase activity](http://purl.obolibrary.org/obo/GO_0008234) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "cysteine protease activity"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:kva"
-- [cysteine-type peptidase activity](http://purl.obolibrary.org/obo/GO_0008234) [label](http://www.w3.org/2000/01/rdf-schema#label) "cysteine-type peptidase activity"
+ - [comment](http://www.w3.org/2000/01/rdf-schema#comment) "PMID:27812932"
-- [cysteine-type peptidase activity](http://purl.obolibrary.org/obo/GO_0008234) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-5660752"
- - [label](http://www.w3.org/2000/01/rdf-schema#label) "USP9X deubiquitinates Ub-SNCA"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:pt"
-- [cysteine-type peptidase activity](http://purl.obolibrary.org/obo/GO_0008234) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-2022381"
- - [label](http://www.w3.org/2000/01/rdf-schema#label) "Cathepsin Z (Cathepsin X) hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8)"
+#### Added
+- [has primary output](http://purl.obolibrary.org/obo/RO_0004008) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "p has primary output c if (a) p has output c and (b) the goal of process is to modify, produce, or transform c."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dph"
-- [cysteine-type peptidase activity](http://purl.obolibrary.org/obo/GO_0008234) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "molecular_function"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) [0000-0002-6601-2165](https://orcid.org/0000-0002-6601-2165)
-- [cysteine-type peptidase activity](http://purl.obolibrary.org/obo/GO_0008234) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:mah"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:kva"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE"
+ - [comment](http://www.w3.org/2000/01/rdf-schema#comment) "PMID:27812932"
-- [cysteine-type peptidase activity](http://purl.obolibrary.org/obo/GO_0008234) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0008234"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:pt"
-- [cysteine-type peptidase activity](http://purl.obolibrary.org/obo/GO_0008234) [has_alternative_id](http://www.geneontology.org/formats/oboInOwl#hasAlternativeId) "GO:0004220"
-- [cysteine-type peptidase activity](http://purl.obolibrary.org/obo/GO_0008234) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-2467809"
- - [label](http://www.w3.org/2000/01/rdf-schema#label) "ESPL1 (Separase) cleaves centromeric cohesin"
+### has regulatory component activity `http://purl.obolibrary.org/obo/RO_0002013`
+#### Removed
+- [has regulatory component activity](http://purl.obolibrary.org/obo/RO_0002013) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "dos"
+
+#### Added
+- [has regulatory component activity](http://purl.obolibrary.org/obo/RO_0002013) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) [0000-0002-7073-9172](https://orcid.org/0000-0002-7073-9172)
+
+
+### has sensory dendrite in `http://purl.obolibrary.org/obo/RO_0013007`
+#### Removed
+- [has sensory dendrite in](http://purl.obolibrary.org/obo/RO_0013007) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) [0000-0002-1373-1705](http://orcid.org/0000-0002-1373-1705)
+
+#### Added
+- [has sensory dendrite in](http://purl.obolibrary.org/obo/RO_0013007) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) [0000-0002-1373-1705](https://orcid.org/0000-0002-1373-1705)
-- [cysteine-type peptidase activity](http://purl.obolibrary.org/obo/GO_0008234) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-2467775"
- - [label](http://www.w3.org/2000/01/rdf-schema#label) "Autocleavage of ESPL1 (Separase)"
-- Class: [cysteine-type peptidase activity](http://purl.obolibrary.org/obo/GO_0008234)
+### has skeleton `http://purl.obolibrary.org/obo/RO_0002551`
+#### Removed
+- [has skeleton](http://purl.obolibrary.org/obo/RO_0002551) Domain [connected anatomical structure](http://purl.obolibrary.org/obo/CARO_0000003)
+
+- [has skeleton](http://purl.obolibrary.org/obo/RO_0002551) Range [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
+ - [editor note](http://purl.obolibrary.org/obo/IAO_0000116) "This should be to a more restricted class, but not the Uberon class may be too restricted since it is a composition-based definition of skeleton rather than functional."
+
+#### Added
+- [has skeleton](http://purl.obolibrary.org/obo/RO_0002551) Domain [anatomical structure](http://purl.obolibrary.org/obo/UBERON_0000061)
-- [cysteine-type peptidase activity](http://purl.obolibrary.org/obo/GO_0008234) SubClassOf [peptidase activity](http://purl.obolibrary.org/obo/GO_0008233)
+- [has skeleton](http://purl.obolibrary.org/obo/RO_0002551) Range [material anatomical entity](http://purl.obolibrary.org/obo/UBERON_0000465)
+ - [editor note](http://purl.obolibrary.org/obo/IAO_0000116) "This should be to a more restricted class, but not the Uberon class may be too restricted since it is a composition-based definition of skeleton rather than functional."
+### has soma location `http://purl.obolibrary.org/obo/RO_0002100`
+#### Removed
+- [has soma location](http://purl.obolibrary.org/obo/RO_0002100) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Relation between a neuron and an anatomical structure that its soma is part of."@en
-### dendritic cell `http://purl.obolibrary.org/obo/CL_0000451`
+- [has soma location](http://purl.obolibrary.org/obo/RO_0002100) Range [connected anatomical structure](http://purl.obolibrary.org/obo/CARO_0000003)
#### Added
-- [dendritic cell](http://purl.obolibrary.org/obo/CL_0000451) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [general_cell_types_upper_slim](http://purl.obolibrary.org/obo/cl#general_cell_types_upper_slim)
+- [has soma location](http://purl.obolibrary.org/obo/RO_0002100) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Relation between a neuron and a material anatomical entity that its soma is part of."@en
+
+- [has soma location](http://purl.obolibrary.org/obo/RO_0002100) Range [material anatomical entity](http://purl.obolibrary.org/obo/UBERON_0000465)
-### deuterosomal cell `http://purl.obolibrary.org/obo/CL_4033044`
+### has synaptic IO in region `http://purl.obolibrary.org/obo/RO_0013001`
+#### Removed
+- [has synaptic IO in region](http://purl.obolibrary.org/obo/RO_0013001) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) [0000-0002-1373-1705](http://orcid.org/0000-0002-1373-1705)
#### Added
-- [deuterosomal cell](http://purl.obolibrary.org/obo/CL_4033044) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "An epithelial cell part of respiratory tract epithelium that is a precursor of a multi-ciliated cell. This cell actively amplifies centrioles, a required step for multiciliogenesis."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:31558434"
+- [has synaptic IO in region](http://purl.obolibrary.org/obo/RO_0013001) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) [0000-0002-1373-1705](https://orcid.org/0000-0002-1373-1705)
+
+
+### head connective tissue `http://purl.obolibrary.org/obo/UBERON_0003566`
+#### Removed
+- [head connective tissue](http://purl.obolibrary.org/obo/UBERON_0003566) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### heart primordium `http://purl.obolibrary.org/obo/UBERON_0003084`
+#### Removed
+- [heart primordium](http://purl.obolibrary.org/obo/UBERON_0003084) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### hemangioblast `http://purl.obolibrary.org/obo/CL_0002418`
+#### Removed
+- [hemangioblast](http://purl.obolibrary.org/obo/CL_0002418) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### hematopoietic lineage restricted progenitor cell `http://purl.obolibrary.org/obo/CL_0002031`
+#### Removed
+- [hematopoietic lineage restricted progenitor cell](http://purl.obolibrary.org/obo/CL_0002031) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### hematopoietic multipotent progenitor cell `http://purl.obolibrary.org/obo/CL_0000837`
+#### Removed
+- [hematopoietic multipotent progenitor cell](http://purl.obolibrary.org/obo/CL_0000837) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
+
+
+
+### hematopoietic oligopotent progenitor cell `http://purl.obolibrary.org/obo/CL_0002032`
+#### Removed
+- [hematopoietic oligopotent progenitor cell](http://purl.obolibrary.org/obo/CL_0002032) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### hematopoietic system `http://purl.obolibrary.org/obo/UBERON_0002390`
+#### Removed
+- [hematopoietic system](http://purl.obolibrary.org/obo/UBERON_0002390) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
+
+
+
+### hemocyte (sensu Arthropoda) `http://purl.obolibrary.org/obo/CL_0000387`
+#### Removed
+- [hemocyte (sensu Arthropoda)](http://purl.obolibrary.org/obo/CL_0000387) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:331922198"
+### hemoglobin subunit zeta `http://purl.obolibrary.org/obo/PR_000008467`
+
+#### Added
+- [hemoglobin subunit zeta](http://purl.obolibrary.org/obo/PR_000008467) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [hemoglobin subunit zeta (human)](http://purl.obolibrary.org/obo/PR_P02008)
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:36883528"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:37291214"
+### hepatic stellate cell `http://purl.obolibrary.org/obo/CL_0000632`
+#### Removed
+- [hepatic stellate cell](http://purl.obolibrary.org/obo/CL_0000632) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-- [deuterosomal cell](http://purl.obolibrary.org/obo/CL_4033044) [date](http://purl.org/dc/terms/date) "2023-06-20T10:27:17Z"^^[dateTime](http://www.w3.org/2001/XMLSchema#dateTime)
-- [deuterosomal cell](http://purl.obolibrary.org/obo/CL_4033044) [contributor](http://purl.org/dc/terms/contributor) [0000-0001-6677-8489](https://orcid.org/0000-0001-6677-8489)
-- [deuterosomal cell](http://purl.obolibrary.org/obo/CL_4033044) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "In humans, deuterosomal cells have been noted to have enriched expression of the following: PLK4, FOXJ1, DEUP1, FOXN4, YPEL1, HES6 and CDC20B. Deuterosomal cells were termed after deuterosomes, the platforms of active centriole amplification."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:31558434"
+### hepatobiliary system `http://purl.obolibrary.org/obo/UBERON_0002423`
+#### Removed
+- [hepatobiliary system](http://purl.obolibrary.org/obo/UBERON_0002423) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:331922198"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:36883528"
-- [deuterosomal cell](http://purl.obolibrary.org/obo/CL_4033044) [contributor](http://purl.org/dc/terms/contributor) [0000-0002-9185-3994](https://orcid.org/0000-0002-9185-3994)
+### hepatocyte `http://purl.obolibrary.org/obo/CL_0000182`
+#### Removed
+- [hepatocyte](http://purl.obolibrary.org/obo/CL_0000182) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [deuterosomal cell](http://purl.obolibrary.org/obo/CL_4033044) [label](http://www.w3.org/2000/01/rdf-schema#label) "deuterosomal cell"
-- Class: [deuterosomal cell](http://purl.obolibrary.org/obo/CL_4033044)
-- [deuterosomal cell](http://purl.obolibrary.org/obo/CL_4033044) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [respiratory tract epithelium](http://purl.obolibrary.org/obo/UBERON_0004802)
+### high affinity immunoglobulin epsilon receptor subunit alpha `http://purl.obolibrary.org/obo/PR_000007431`
-- [deuterosomal cell](http://purl.obolibrary.org/obo/CL_4033044) SubClassOf [respiratory epithelial cell](http://purl.obolibrary.org/obo/CL_0002368)
+#### Added
+- [high affinity immunoglobulin epsilon receptor subunit alpha](http://purl.obolibrary.org/obo/PR_000007431) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [high affinity immunoglobulin epsilon receptor subunit alpha (human)](http://purl.obolibrary.org/obo/PR_P12319)
-### dorsal striatum `http://purl.obolibrary.org/obo/UBERON_0005382`
+### high affinity immunoglobulin gamma Fc receptor I `http://purl.obolibrary.org/obo/PR_000001465`
#### Added
-- [dorsal striatum](http://purl.obolibrary.org/obo/UBERON_0005382) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "MA:0002971"
+- [high affinity immunoglobulin gamma Fc receptor I](http://purl.obolibrary.org/obo/PR_000001465) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [high affinity immunoglobulin gamma Fc receptor I (human)](http://purl.obolibrary.org/obo/PR_P12314)
+
+
+### hindgut `http://purl.obolibrary.org/obo/UBERON_0001046`
+#### Removed
+- [hindgut](http://purl.obolibrary.org/obo/UBERON_0001046) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
-- [dorsal striatum](http://purl.obolibrary.org/obo/UBERON_0005382) [UBPROP_0000001](http://purl.obolibrary.org/obo/UBPROP_0000001) "It may also refer to both the basal ganglia and the internal capsule collectively."
- - [source](http://www.geneontology.org/formats/oboInOwl#source) "Wikipedia:Dorsal_striatum"
-- [dorsal striatum](http://purl.obolibrary.org/obo/UBERON_0005382) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "BAMS:STRd"
+### hip connective tissue `http://purl.obolibrary.org/obo/UBERON_0003576`
+#### Removed
+- [hip connective tissue](http://purl.obolibrary.org/obo/UBERON_0003576) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
-- [dorsal striatum](http://purl.obolibrary.org/obo/UBERON_0005382) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "caudoputamen"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "NLXANAT:100312"
-- [dorsal striatum](http://purl.obolibrary.org/obo/UBERON_0005382) [id](http://www.geneontology.org/formats/oboInOwl#id) "UBERON:0005382"
+### hippocampus granule cell layer `http://purl.obolibrary.org/obo/UBERON_0005367`
+#### Removed
+- [hippocampus granule cell layer](http://purl.obolibrary.org/obo/UBERON_0005367) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [dorsal striatum](http://purl.obolibrary.org/obo/UBERON_0005382) [UBPROP_0000001](http://purl.obolibrary.org/obo/UBPROP_0000001) "It may also refer to the putamen and caudate collectively."
- - [source](http://www.geneontology.org/formats/oboInOwl#source) "Wikipedia:Dorsal_striatum"
-- [dorsal striatum](http://purl.obolibrary.org/obo/UBERON_0005382) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Dorsal components of the striatum comprising the caudate nucleus and the putamen, in species that have distinct nuclei; the caudoputamen in species which don't."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "NLXANAT:1010001"
-- [dorsal striatum](http://purl.obolibrary.org/obo/UBERON_0005382) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "striatum dorsale"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "BTO:0004701"
+### homeobox protein Meis2 `http://purl.obolibrary.org/obo/PR_000010317`
-- [dorsal striatum](http://purl.obolibrary.org/obo/UBERON_0005382) [label](http://www.w3.org/2000/01/rdf-schema#label) "dorsal striatum"
+#### Added
+- [homeobox protein Meis2](http://purl.obolibrary.org/obo/PR_000010317) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [homeobox protein Meis2 (human)](http://purl.obolibrary.org/obo/PR_O14770)
-- [dorsal striatum](http://purl.obolibrary.org/obo/UBERON_0005382) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "FMA:77620"
-- [dorsal striatum](http://purl.obolibrary.org/obo/UBERON_0005382) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "corpus striatum"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Wikipedia:Dorsal_striatum"
+### hyoid arch skeleton `http://purl.obolibrary.org/obo/UBERON_0005884`
+#### Removed
+- [hyoid arch skeleton](http://purl.obolibrary.org/obo/UBERON_0005884) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [dorsal striatum](http://purl.obolibrary.org/obo/UBERON_0005382) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Wikipedia:Dorsal_striatum"
-- [dorsal striatum](http://purl.obolibrary.org/obo/UBERON_0005382) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "uberon"
-- [dorsal striatum](http://purl.obolibrary.org/obo/UBERON_0005382) [UBPROP_0000001](http://purl.obolibrary.org/obo/UBPROP_0000001) "The term dorsal striatum refers to a composite structure of the endbrain that is defined in the striatopallidal system by connectivity and neurochemical staining. It includes most of the striatum ( Heimer-1995 ). The boundary between this structure and the ventral striatum is indistinct in sections stained for Nissl substance."
- - [source](http://www.geneontology.org/formats/oboInOwl#source) "neuronames:2340"
+### hypoglossal nerve `http://purl.obolibrary.org/obo/UBERON_0001650`
+#### Removed
+- [hypoglossal nerve](http://purl.obolibrary.org/obo/UBERON_0001650) SubClassOf [neuron projection bundle](http://purl.obolibrary.org/obo/CARO_0001001)
-- [dorsal striatum](http://purl.obolibrary.org/obo/UBERON_0005382) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "dorsal basal ganglion"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "BTO:0004701"
-- [dorsal striatum](http://purl.obolibrary.org/obo/UBERON_0005382) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "MBA:485"
-- [dorsal striatum](http://purl.obolibrary.org/obo/UBERON_0005382) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "striatum dorsal region"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ABA:STRd"
+### hypothalamus kisspeptin neuron `http://purl.obolibrary.org/obo/CL_4023123`
+#### Removed
+- [hypothalamus kisspeptin neuron](http://purl.obolibrary.org/obo/CL_4023123) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [dorsal striatum](http://purl.obolibrary.org/obo/UBERON_0005382) [UBPROP_0000001](http://purl.obolibrary.org/obo/UBPROP_0000001) "According to BrainInfo it is a part of the basal ganglia comprising the globus pallidus and striatum"
- - [source](http://www.geneontology.org/formats/oboInOwl#source) "Wikipedia:Dorsal_striatum"
-- [dorsal striatum](http://purl.obolibrary.org/obo/UBERON_0005382) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "dorsal basal ganglia"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "BTO:0004701"
-- [dorsal striatum](http://purl.obolibrary.org/obo/UBERON_0005382) [UBPROP_0000001](http://purl.obolibrary.org/obo/UBPROP_0000001) "According to the 1917 version of Gray's Anatomy, it is the combination of the lentiform nucleus (putamen and the globus pallidus) and the caudate nucleus"
- - [source](http://www.geneontology.org/formats/oboInOwl#source) "Wikipedia:Dorsal_striatum"
+### immature eye `http://purl.obolibrary.org/obo/UBERON_0010312`
+#### Removed
+- [immature eye](http://purl.obolibrary.org/obo/UBERON_0010312) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [dorsal striatum](http://purl.obolibrary.org/obo/UBERON_0005382) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "BTO:0004701"
-- [dorsal striatum](http://purl.obolibrary.org/obo/UBERON_0005382) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "NLXANAT:1010001"
-- [dorsal striatum](http://purl.obolibrary.org/obo/UBERON_0005382) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "BAMS:Dorsal_striatum"
+### immature single positive thymocyte `http://purl.obolibrary.org/obo/CL_0000805`
+#### Removed
+- [immature single positive thymocyte](http://purl.obolibrary.org/obo/CL_0000805) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-- [dorsal striatum](http://purl.obolibrary.org/obo/UBERON_0005382) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "neuronames:2340"
-- [dorsal striatum](http://purl.obolibrary.org/obo/UBERON_0005382) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "EMAPA:36575"
-- [dorsal striatum](http://purl.obolibrary.org/obo/UBERON_0005382) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "striated body"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Wikipedia:Dorsal_striatum"
+### immunoglobulin iota chain `http://purl.obolibrary.org/obo/PR_000001858`
-- [dorsal striatum](http://purl.obolibrary.org/obo/UBERON_0005382) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "BAMS:StrD"
+#### Added
+- [immunoglobulin iota chain](http://purl.obolibrary.org/obo/PR_000001858) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [immunoglobulin iota chain (human)](http://purl.obolibrary.org/obo/PR_P12018)
-- [dorsal striatum](http://purl.obolibrary.org/obo/UBERON_0005382) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PBA:10081"
-- Class: [dorsal striatum](http://purl.obolibrary.org/obo/UBERON_0005382)
+### immunoglobulin lambda-like polypeptide 1 `http://purl.obolibrary.org/obo/PR_000001859`
-- [dorsal striatum](http://purl.obolibrary.org/obo/UBERON_0005382) SubClassOf [gray matter of telencephalon](http://purl.obolibrary.org/obo/UBERON_0011300)
+#### Added
+- [immunoglobulin lambda-like polypeptide 1](http://purl.obolibrary.org/obo/PR_000001859) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [immunoglobulin lambda-like polypeptide 1 (human)](http://purl.obolibrary.org/obo/PR_P15814)
-- [dorsal striatum](http://purl.obolibrary.org/obo/UBERON_0005382) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [striatum](http://purl.obolibrary.org/obo/UBERON_0002435)
- - [source](http://www.geneontology.org/formats/oboInOwl#source) "NIFSTD"
-- [dorsal striatum](http://purl.obolibrary.org/obo/UBERON_0005382) SubClassOf [has part](http://purl.obolibrary.org/obo/BFO_0000051) some [putamen](http://purl.obolibrary.org/obo/UBERON_0001874)
+### in taxon `http://purl.obolibrary.org/obo/RO_0002162`
+#### Removed
+- [in taxon](http://purl.obolibrary.org/obo/RO_0002162) Range [organism](http://purl.obolibrary.org/obo/CARO_0001010)
-- [dorsal striatum](http://purl.obolibrary.org/obo/UBERON_0005382) SubClassOf [has part](http://purl.obolibrary.org/obo/BFO_0000051) some [caudate nucleus](http://purl.obolibrary.org/obo/UBERON_0001873)
-### endocrine cell `http://purl.obolibrary.org/obo/CL_0000163`
+### independent continuant `http://purl.obolibrary.org/obo/BFO_0000004`
+#### Removed
+- [independent continuant](http://purl.obolibrary.org/obo/BFO_0000004) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A continuant that is a bearer of quality and realizable entity entities, in which other entities inhere and which itself cannot inhere in anything."@en
#### Added
-- [endocrine cell](http://purl.obolibrary.org/obo/CL_0000163) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [general_cell_types_upper_slim](http://purl.obolibrary.org/obo/cl#general_cell_types_upper_slim)
+- [independent continuant](http://purl.obolibrary.org/obo/BFO_0000004) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "A continuant that is a bearer of quality and realizable entity entities, in which other entities inhere and which itself cannot inhere in anything."@en
+
+- [independent continuant](http://purl.obolibrary.org/obo/BFO_0000004) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "b is an independent continuant = Def. b is a continuant which is such that there is no c and no t such that b s-depends_on c at t. (axiom label in BFO2 Reference: [017-002])"@en
-### endometrial ciliated epithelial cell `http://purl.obolibrary.org/obo/CL_4030040`
+### indirectly causally upstream of `http://purl.obolibrary.org/obo/RO_0012011`
#### Removed
-- [endometrial ciliated epithelial cell](http://purl.obolibrary.org/obo/CL_4030040) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A ciliated cell of the endometrial epithelium. The cilia of this cell type help move mucus from glandular tissue of the endometrium."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "https://www.nature.com/articles/s41591-020-1040-z"
+- [indirectly causally upstream of](http://purl.obolibrary.org/obo/RO_0012011) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "pg"
+
+#### Added
+- [indirectly causally upstream of](http://purl.obolibrary.org/obo/RO_0012011) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) [0000-0003-1813-6857](https://orcid.org/0000-0003-1813-6857)
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "https://www.proteinatlas.org/humanproteome/single+cell+type/Glandular+epithelial+cells#endometrialciliatedcells"
+
+### indirectly negatively regulates `http://purl.obolibrary.org/obo/RO_0002409`
#### Added
-- [endometrial ciliated epithelial cell](http://purl.obolibrary.org/obo/CL_4030040) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A ciliated cell of the endometrial epithelium. The cilia of this cell type help move mucus from glandular tissue of the endometrium."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1038/s41591-020-1040-z"
+- [indirectly negatively regulates](http://purl.obolibrary.org/obo/RO_0002409) [see also](http://www.w3.org/2000/01/rdf-schema#seeAlso) "https://wiki.geneontology.org/Indirectly_negatively_regulates"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI)
+
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "https://www.proteinatlas.org/humanproteome/single+cell+type/Glandular+epithelial+cells#endometrialciliatedcells"
+### indirectly positively regulates `http://purl.obolibrary.org/obo/RO_0002407`
+
+#### Added
+- [indirectly positively regulates](http://purl.obolibrary.org/obo/RO_0002407) [see also](http://www.w3.org/2000/01/rdf-schema#seeAlso) "https://wiki.geneontology.org/Indirectly_positively_regulates"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI)
-### endothelium of arteriole `http://purl.obolibrary.org/obo/UBERON_0001916`
+### indirectly regulates `http://purl.obolibrary.org/obo/RO_0012012`
#### Removed
-- [endothelium of arteriole](http://purl.obolibrary.org/obo/UBERON_0001916) [present_in_taxon](http://purl.obolibrary.org/obo/RO_0002175) [Homo sapiens](http://purl.obolibrary.org/obo/NCBITaxon_9606)
+- [indirectly regulates](http://purl.obolibrary.org/obo/RO_0012012) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "pg"
+
+#### Added
+- [indirectly regulates](http://purl.obolibrary.org/obo/RO_0012012) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) [0000-0003-1813-6857](https://orcid.org/0000-0003-1813-6857)
-- [endothelium of arteriole](http://purl.obolibrary.org/obo/UBERON_0001916) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [human_reference_atlas](http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas)
+
+### individual digit of digitopodial skeleton `http://purl.obolibrary.org/obo/UBERON_5102544`
+#### Removed
+- [individual digit of digitopodial skeleton](http://purl.obolibrary.org/obo/UBERON_5102544) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000)
-### epithelial cell `http://purl.obolibrary.org/obo/CL_0000066`
+### inducible T-cell costimulator `http://purl.obolibrary.org/obo/PR_000001860`
#### Added
-- [epithelial cell](http://purl.obolibrary.org/obo/CL_0000066) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [general_cell_types_upper_slim](http://purl.obolibrary.org/obo/cl#general_cell_types_upper_slim)
+- [inducible T-cell costimulator](http://purl.obolibrary.org/obo/PR_000001860) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [inducible T-cell costimulator (human)](http://purl.obolibrary.org/obo/PR_Q9Y6W8)
-### establishment of cell polarity involved in ameboidal cell migration `http://purl.obolibrary.org/obo/GO_0003365`
+### information content entity `http://purl.obolibrary.org/obo/IAO_0000030`
#### Added
-- [establishment of cell polarity involved in ameboidal cell migration](http://purl.obolibrary.org/obo/GO_0003365) [never in taxon](http://purl.obolibrary.org/obo/RO_0002161) [Fungi](http://purl.obolibrary.org/obo/NCBITaxon_4751)
+- [information content entity](http://purl.obolibrary.org/obo/IAO_0000030) [IAO_0000112](http://purl.obolibrary.org/obo/IAO_0000112) "Examples of information content entites include journal articles, data, graphical layouts, and graphs."@en
+
+- [information content entity](http://purl.obolibrary.org/obo/IAO_0000030) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "information content entity"@en
+
+- [information content entity](http://purl.obolibrary.org/obo/IAO_0000030) [editor note](http://purl.obolibrary.org/obo/IAO_0000116) "2014-03-10: The use of "thing" is intended to be general enough to include universals and configurations (see https://groups.google.com/d/msg/information-ontology/GBxvYZCk1oc/-L6B5fSBBTQJ)."@en
+
+- [information content entity](http://purl.obolibrary.org/obo/IAO_0000030) [editor note](http://purl.obolibrary.org/obo/IAO_0000116) "information_content_entity 'is_encoded_in' some digital_entity in obi before split (040907). information_content_entity 'is_encoded_in' some physical_document in obi before split (040907).
+
+Previous. An information content entity is a non-realizable information entity that 'is encoded in' some digital or physical entity."@en
+
+- [information content entity](http://purl.obolibrary.org/obo/IAO_0000030) [IAO_0000119](http://purl.obolibrary.org/obo/IAO_0000119) "OBI_0000142"@en
+
+- [information content entity](http://purl.obolibrary.org/obo/IAO_0000030) [IAO_0000117](http://purl.obolibrary.org/obo/IAO_0000117) "PERSON: Chris Stoeckert"@en
+
+- [information content entity](http://purl.obolibrary.org/obo/IAO_0000030) [IAO_0000114](http://purl.obolibrary.org/obo/IAO_0000114) [ready for release](http://purl.obolibrary.org/obo/IAO_0000122)
+
+- [information content entity](http://purl.obolibrary.org/obo/IAO_0000030) [label](http://www.w3.org/2000/01/rdf-schema#label) "information content entity"@en
+
+- [information content entity](http://purl.obolibrary.org/obo/IAO_0000030) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A generically dependent continuant that is about some thing."@en
+
+- Class: [information content entity](http://purl.obolibrary.org/obo/IAO_0000030)
+
+- [information content entity](http://purl.obolibrary.org/obo/IAO_0000030) SubClassOf [is about](http://purl.obolibrary.org/obo/IAO_0000136) some [BFO_0000001](http://purl.obolibrary.org/obo/BFO_0000001)
+
+- [information content entity](http://purl.obolibrary.org/obo/IAO_0000030) SubClassOf [generically dependent continuant](http://purl.obolibrary.org/obo/BFO_0000031)
+
+
+### inner cell mass `http://purl.obolibrary.org/obo/UBERON_0000087`
+#### Removed
+- [inner cell mass](http://purl.obolibrary.org/obo/UBERON_0000087) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### inner cell mass derived epiblast `http://purl.obolibrary.org/obo/UBERON_0008780`
+#### Removed
+- [inner cell mass derived epiblast](http://purl.obolibrary.org/obo/UBERON_0008780) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### inner limiting layer of retina `http://purl.obolibrary.org/obo/UBERON_0001794`
+#### Removed
+- [inner limiting layer of retina](http://purl.obolibrary.org/obo/UBERON_0001794) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
-- [establishment of cell polarity involved in ameboidal cell migration](http://purl.obolibrary.org/obo/GO_0003365) DisjointWith [in taxon](http://purl.obolibrary.org/obo/RO_0002162) some [Fungi](http://purl.obolibrary.org/obo/NCBITaxon_4751)
-- [establishment of cell polarity involved in ameboidal cell migration](http://purl.obolibrary.org/obo/GO_0003365) SubClassOf not ([in taxon](http://purl.obolibrary.org/obo/RO_0002162) some [Fungi](http://purl.obolibrary.org/obo/NCBITaxon_4751))
+### inner nuclear layer of retina `http://purl.obolibrary.org/obo/UBERON_0001791`
+#### Removed
+- [inner nuclear layer of retina](http://purl.obolibrary.org/obo/UBERON_0001791) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
-- [establishment of cell polarity involved in ameboidal cell migration](http://purl.obolibrary.org/obo/GO_0003365) SubClassOf [in taxon](http://purl.obolibrary.org/obo/RO_0002162) some (not ([Fungi](http://purl.obolibrary.org/obo/NCBITaxon_4751)))
+### innervated_by `http://purl.obolibrary.org/obo/RO_0002005`
+#### Removed
+- [innervated_by](http://purl.obolibrary.org/obo/RO_0002005) Domain [connected anatomical structure](http://purl.obolibrary.org/obo/CARO_0000003)
-### exocrine cell `http://purl.obolibrary.org/obo/CL_0000152`
+- [innervated_by](http://purl.obolibrary.org/obo/RO_0002005) Range [neuron projection bundle](http://purl.obolibrary.org/obo/CARO_0001001)
#### Added
-- [exocrine cell](http://purl.obolibrary.org/obo/CL_0000152) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [general_cell_types_upper_slim](http://purl.obolibrary.org/obo/cl#general_cell_types_upper_slim)
+- [innervated_by](http://purl.obolibrary.org/obo/RO_0002005) Domain [anatomical structure](http://purl.obolibrary.org/obo/UBERON_0000061)
+
+- [innervated_by](http://purl.obolibrary.org/obo/RO_0002005) Range [neuron projection bundle](http://purl.obolibrary.org/obo/UBERON_0000122)
-### extraembryonic cell `http://purl.obolibrary.org/obo/CL_0000349`
+### innervates `http://purl.obolibrary.org/obo/RO_0002134`
+#### Removed
+- [innervates](http://purl.obolibrary.org/obo/RO_0002134) Domain [neuron projection bundle](http://purl.obolibrary.org/obo/CARO_0001001)
#### Added
-- [extraembryonic cell](http://purl.obolibrary.org/obo/CL_0000349) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [general_cell_types_upper_slim](http://purl.obolibrary.org/obo/cl#general_cell_types_upper_slim)
+- [innervates](http://purl.obolibrary.org/obo/RO_0002134) Domain [neuron projection bundle](http://purl.obolibrary.org/obo/UBERON_0000122)
-### fat cell `http://purl.obolibrary.org/obo/CL_0000136`
+### insulin gene translation product `http://purl.obolibrary.org/obo/PR_000009054`
#### Added
-- [fat cell](http://purl.obolibrary.org/obo/CL_0000136) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [general_cell_types_upper_slim](http://purl.obolibrary.org/obo/cl#general_cell_types_upper_slim)
+- [insulin gene translation product](http://purl.obolibrary.org/obo/PR_000009054) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [insulin gene translation product (human)](http://purl.obolibrary.org/obo/PR_P01308)
-### fetal pre-type II pneumocyte `http://purl.obolibrary.org/obo/CL_4040003`
+### integrin alpha-2 `http://purl.obolibrary.org/obo/PR_000001008`
#### Added
-- [fetal pre-type II pneumocyte](http://purl.obolibrary.org/obo/CL_4040003) [note](http://www.geneontology.org/formats/oboInOwl#note) "According to PMID:1316350 this cell type does not yet produce surfactant. According to PMID:9109447 and PMID:12114192 this cell type produces low levels of surfactant that can be increased by administration of very low-density lipoproteins. This cell type is of medical relevance, as a central feature of the fetal respiratory distress syndrome seems to be the presence in the lung of abundant pre-type II alveolar epithelial cells (PMID:1316350)."
+- [integrin alpha-2](http://purl.obolibrary.org/obo/PR_000001008) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [integrin alpha-2 (human)](http://purl.obolibrary.org/obo/PR_P17301)
-- [fetal pre-type II pneumocyte](http://purl.obolibrary.org/obo/CL_4040003) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "fetal pre-type 2 pneumocyte"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "https://orcid.org/0000-0002-0819-0473"
-- [fetal pre-type II pneumocyte](http://purl.obolibrary.org/obo/CL_4040003) [label](http://www.w3.org/2000/01/rdf-schema#label) "fetal pre-type II pneumocyte"
+### integrin alpha-4 `http://purl.obolibrary.org/obo/PR_000009129`
-- [fetal pre-type II pneumocyte](http://purl.obolibrary.org/obo/CL_4040003) [date](http://purl.org/dc/terms/date) "2023-06-02T09:19:31Z"^^[dateTime](http://www.w3.org/2001/XMLSchema#dateTime)
+#### Added
+- [integrin alpha-4](http://purl.obolibrary.org/obo/PR_000009129) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [integrin alpha-4 (human)](http://purl.obolibrary.org/obo/PR_P13612)
-- [fetal pre-type II pneumocyte](http://purl.obolibrary.org/obo/CL_4040003) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "fetal alveolar pre-type II epithelial cell"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:9624168"
-- [fetal pre-type II pneumocyte](http://purl.obolibrary.org/obo/CL_4040003) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "fetal pre-type II alveolar epithelial cell"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:12114192"
+### integrin alpha-E `http://purl.obolibrary.org/obo/PR_000001010`
-- [fetal pre-type II pneumocyte](http://purl.obolibrary.org/obo/CL_4040003) [contributor](http://purl.org/dc/terms/contributor) [0000-0002-0819-0473](https://orcid.org/0000-0002-0819-0473)
+#### Added
+- [integrin alpha-E](http://purl.obolibrary.org/obo/PR_000001010) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [integrin alpha-E (human)](http://purl.obolibrary.org/obo/PR_P38570)
-- [fetal pre-type II pneumocyte](http://purl.obolibrary.org/obo/CL_4040003) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Precursor of type II pneumocyte. These cells do not have lamellar bodies, which are a marker of type II pneumocyte maturity."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:1316350"
-- Class: [fetal pre-type II pneumocyte](http://purl.obolibrary.org/obo/CL_4040003)
+### integrin alpha-IIb `http://purl.obolibrary.org/obo/PR_000009127`
-- [fetal pre-type II pneumocyte](http://purl.obolibrary.org/obo/CL_4040003) SubClassOf [pneumocyte](http://purl.obolibrary.org/obo/CL_0000322)
+#### Added
+- [integrin alpha-IIb](http://purl.obolibrary.org/obo/PR_000009127) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [integrin alpha-IIb (human)](http://purl.obolibrary.org/obo/PR_P08514)
-### fibroblast `http://purl.obolibrary.org/obo/CL_0000057`
+### integrin alpha-M `http://purl.obolibrary.org/obo/PR_000001012`
#### Added
-- [fibroblast](http://purl.obolibrary.org/obo/CL_0000057) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [general_cell_types_upper_slim](http://purl.obolibrary.org/obo/cl#general_cell_types_upper_slim)
+- [integrin alpha-M](http://purl.obolibrary.org/obo/PR_000001012) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [integrin alpha-M (human)](http://purl.obolibrary.org/obo/PR_P11215)
-- [fibroblast](http://purl.obolibrary.org/obo/CL_0000057) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "NCIT:C12482"
+### integrin alpha-X `http://purl.obolibrary.org/obo/PR_000001013`
-### follicle stem cell (sensu Arthropoda) `http://purl.obolibrary.org/obo/CL_0000441`
-#### Removed
-- [follicle stem cell (sensu Arthropoda)](http://purl.obolibrary.org/obo/CL_0000441) [label](http://www.w3.org/2000/01/rdf-schema#label) "follicle stem cell"
+#### Added
+- [integrin alpha-X](http://purl.obolibrary.org/obo/PR_000001013) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [integrin alpha-X (human)](http://purl.obolibrary.org/obo/PR_P20702)
+
+
+### integrin beta-7 `http://purl.obolibrary.org/obo/PR_000009143`
#### Added
-- [follicle stem cell (sensu Arthropoda)](http://purl.obolibrary.org/obo/CL_0000441) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "somatic stem cell"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/j.devcel.2005.08.012"
+- [integrin beta-7](http://purl.obolibrary.org/obo/PR_000009143) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [integrin beta-7 (human)](http://purl.obolibrary.org/obo/PR_P26010)
+
+
+### integument `http://purl.obolibrary.org/obo/UBERON_0002199`
+#### Removed
+- [integument](http://purl.obolibrary.org/obo/UBERON_0002199) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
+
+
+
+### integumental system `http://purl.obolibrary.org/obo/UBERON_0002416`
+#### Removed
+- [integumental system](http://purl.obolibrary.org/obo/UBERON_0002416) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
+
-- [follicle stem cell (sensu Arthropoda)](http://purl.obolibrary.org/obo/CL_0000441) [label](http://www.w3.org/2000/01/rdf-schema#label) "follicle stem cell (sensu Arthropoda)"
-- [follicle stem cell (sensu Arthropoda)](http://purl.obolibrary.org/obo/CL_0000441) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A stem cell that gives rise to the follicle cells that surround the oocyte in female arthropods."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1242/dev.121.11.3797"
+### interleukin-1 receptor-like 1 `http://purl.obolibrary.org/obo/PR_000008994`
+
+#### Added
+- [interleukin-1 receptor-like 1](http://purl.obolibrary.org/obo/PR_000008994) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [interleukin-1 receptor-like 1 (human)](http://purl.obolibrary.org/obo/PR_Q01638)
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/B978-012369493-5.50005-5"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1038/s41467-020-19361-0"
+### interleukin-17 receptor B `http://purl.obolibrary.org/obo/PR_000008982`
-- [follicle stem cell (sensu Arthropoda)](http://purl.obolibrary.org/obo/CL_0000441) SubClassOf [only in taxon](http://purl.obolibrary.org/obo/RO_0002160) some [Arthropoda](http://purl.obolibrary.org/obo/NCBITaxon_6656)
- - [term tracker item](http://purl.obolibrary.org/obo/IAO_0000233) "https://github.com/obophenotype/cell-ontology/issues/1943"
+#### Added
+- [interleukin-17 receptor B](http://purl.obolibrary.org/obo/PR_000008982) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [interleukin-17 receptor B (human)](http://purl.obolibrary.org/obo/PR_Q9NRM6)
-### general_cell_types_upper_slim `http://purl.obolibrary.org/obo/cl#general_cell_types_upper_slim`
+### interleukin-2 receptor subunit alpha `http://purl.obolibrary.org/obo/PR_000001380`
#### Added
-- [general_cell_types_upper_slim](http://purl.obolibrary.org/obo/cl#general_cell_types_upper_slim) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "a subset of general classes of cell types in the cell ontology."
+- [interleukin-2 receptor subunit alpha](http://purl.obolibrary.org/obo/PR_000001380) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [interleukin-2 receptor subunit alpha (human)](http://purl.obolibrary.org/obo/PR_P01589)
-- [general_cell_types_upper_slim](http://purl.obolibrary.org/obo/cl#general_cell_types_upper_slim) [label](http://www.w3.org/2000/01/rdf-schema#label) "general_cell_types_upper_slim"
-- AnnotationProperty: [general_cell_types_upper_slim](http://purl.obolibrary.org/obo/cl#general_cell_types_upper_slim)
+### interleukin-2 receptor subunit beta `http://purl.obolibrary.org/obo/PR_000001381`
-- [general_cell_types_upper_slim](http://purl.obolibrary.org/obo/cl#general_cell_types_upper_slim) SubPropertyOf: [subset_property](http://www.geneontology.org/formats/oboInOwl#SubsetProperty)
+#### Added
+- [interleukin-2 receptor subunit beta](http://purl.obolibrary.org/obo/PR_000001381) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [interleukin-2 receptor subunit beta (human)](http://purl.obolibrary.org/obo/PR_P14784)
-### germ cell `http://purl.obolibrary.org/obo/CL_0000586`
+### interleukin-5 receptor subunit alpha `http://purl.obolibrary.org/obo/PR_000001867`
#### Added
-- [germ cell](http://purl.obolibrary.org/obo/CL_0000586) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "NCIT:C12597"
+- [interleukin-5 receptor subunit alpha](http://purl.obolibrary.org/obo/PR_000001867) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [interleukin-5 receptor subunit alpha (human)](http://purl.obolibrary.org/obo/PR_Q01344)
-### germ cell development `http://purl.obolibrary.org/obo/GO_0007281`
+### interleukin-7 receptor subunit alpha `http://purl.obolibrary.org/obo/PR_000001869`
#### Added
-- [germ cell development](http://purl.obolibrary.org/obo/GO_0007281) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "gametogenesis"
+- [interleukin-7 receptor subunit alpha](http://purl.obolibrary.org/obo/PR_000001869) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [interleukin-7 receptor subunit alpha (human)](http://purl.obolibrary.org/obo/PR_P16871)
+
+
+### intermaxillary process `http://purl.obolibrary.org/obo/UBERON_0009714`
+#### Removed
+- [intermaxillary process](http://purl.obolibrary.org/obo/UBERON_0009714) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
-### germ line cell `http://purl.obolibrary.org/obo/CL_0000039`
+### intermediate cell of urothelium `http://purl.obolibrary.org/obo/CL_4030055`
+#### Removed
+- [intermediate cell of urothelium](http://purl.obolibrary.org/obo/CL_4030055) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "
urothelial intermediate cell"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1007/978-3-030-14366-4_8"
#### Added
-- [germ line cell](http://purl.obolibrary.org/obo/CL_0000039) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [general_cell_types_upper_slim](http://purl.obolibrary.org/obo/cl#general_cell_types_upper_slim)
+- [intermediate cell of urothelium](http://purl.obolibrary.org/obo/CL_4030055) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "urothelial intermediate cell"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1007/978-3-030-14366-4_8"
+
+
+### intermediate mesoderm `http://purl.obolibrary.org/obo/UBERON_0003064`
+#### Removed
+- [intermediate mesoderm](http://purl.obolibrary.org/obo/UBERON_0003064) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-### glandular endometrial ciliated epithelial cell `http://purl.obolibrary.org/obo/CL_4030042`
+
+### internal ear `http://purl.obolibrary.org/obo/UBERON_0001846`
+#### Removed
+- [internal ear](http://purl.obolibrary.org/obo/UBERON_0001846) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### interneuromast cell `http://purl.obolibrary.org/obo/CL_0000854`
+#### Removed
+- [interneuromast cell](http://purl.obolibrary.org/obo/CL_0000854) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### interplexiform cell `http://purl.obolibrary.org/obo/CL_0011104`
+#### Removed
+- [interplexiform cell](http://purl.obolibrary.org/obo/CL_0011104) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### interventricular septum membranous part `http://purl.obolibrary.org/obo/UBERON_0004666`
+#### Removed
+- [interventricular septum membranous part](http://purl.obolibrary.org/obo/UBERON_0004666) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### intestinal villus `http://purl.obolibrary.org/obo/UBERON_0001213`
+#### Removed
+- [intestinal villus](http://purl.obolibrary.org/obo/UBERON_0001213) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### intraembryonic coelom `http://purl.obolibrary.org/obo/UBERON_0003887`
#### Removed
-- [glandular endometrial ciliated epithelial cell](http://purl.obolibrary.org/obo/CL_4030042) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A ciliated cell of the endometrial glandular epithelium."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "https://www.nature.com/articles/s41591-020-1040-z"
+- [intraembryonic coelom](http://purl.obolibrary.org/obo/UBERON_0003887) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### intratelencephalic-projecting glutamatergic cortical neuron `http://purl.obolibrary.org/obo/CL_4023008`
#### Added
-- [glandular endometrial ciliated epithelial cell](http://purl.obolibrary.org/obo/CL_4030042) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A ciliated cell of the endometrial glandular epithelium."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1038/s41591-020-1040-z"
+- [intratelencephalic-projecting glutamatergic cortical neuron](http://purl.obolibrary.org/obo/CL_4023008) [symbol](http://purl.obolibrary.org/obo/IAO_0000028) "IT glut"
-### glial cell `http://purl.obolibrary.org/obo/CL_0000125`
+### invertebrate nurse cell `http://purl.obolibrary.org/obo/CL_0000026`
+#### Removed
+- [invertebrate nurse cell](http://purl.obolibrary.org/obo/CL_0000026) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
+
+
+### inverted L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (Mmus) `http://purl.obolibrary.org/obo/CL_4023081`
#### Added
-- [glial cell](http://purl.obolibrary.org/obo/CL_0000125) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [general_cell_types_upper_slim](http://purl.obolibrary.org/obo/cl#general_cell_types_upper_slim)
+- [inverted L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (Mmus)](http://purl.obolibrary.org/obo/CL_4023081) [symbol](http://purl.obolibrary.org/obo/IAO_0000028) "inverted L6 IT glut MOp"
-### glomerular visceral epithelium `http://purl.obolibrary.org/obo/UBERON_0005751`
+### involved in `http://purl.obolibrary.org/obo/RO_0002331`
+#### Removed
+- [involved in](http://purl.obolibrary.org/obo/RO_0002331) [see also](http://www.w3.org/2000/01/rdf-schema#seeAlso) [Involved_in](http://wiki.geneontology.org/index.php/Involved_in)
#### Added
-- [glomerular visceral epithelium](http://purl.obolibrary.org/obo/UBERON_0005751) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [human_reference_atlas](http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas)
+- [involved in](http://purl.obolibrary.org/obo/RO_0002331) [see also](http://www.w3.org/2000/01/rdf-schema#seeAlso) "https://wiki.geneontology.org/Involved_in"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI)
+
+
+### iridophore `http://purl.obolibrary.org/obo/CL_0000431`
+#### Removed
+- [iridophore](http://purl.obolibrary.org/obo/CL_0000431) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [glomerular visceral epithelium](http://purl.obolibrary.org/obo/UBERON_0005751) [present_in_taxon](http://purl.obolibrary.org/obo/RO_0002175) [Homo sapiens](http://purl.obolibrary.org/obo/NCBITaxon_9606)
-### granule cell `http://purl.obolibrary.org/obo/CL_0000120`
+### iris nerve `http://purl.obolibrary.org/obo/UBERON_0003438`
+#### Removed
+- [iris nerve](http://purl.obolibrary.org/obo/UBERON_0003438) SubClassOf [neuron projection bundle](http://purl.obolibrary.org/obo/CARO_0001001)
-#### Added
-- [granule cell](http://purl.obolibrary.org/obo/CL_0000120) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A neuron of the vertebrate central nervous system that is small in size. This general class includes small neurons in the granular layer of the cerebellar cortex, cerebral cortex neurons that are not pyramidal cells and small neurons without axons found in the olfactory bulb."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) [cell](https://medical-dictionary.thefreedictionary.com/granule+cell)
-### intermediate cell of urothelium `http://purl.obolibrary.org/obo/CL_4030055`
+### is about `http://purl.obolibrary.org/obo/IAO_0000136`
#### Added
-- [intermediate cell of urothelium](http://purl.obolibrary.org/obo/CL_4030055) [date](http://purl.org/dc/terms/date) "2023-06-16T07:53:43Z"^^[dateTime](http://www.w3.org/2001/XMLSchema#dateTime)
+- [is about](http://purl.obolibrary.org/obo/IAO_0000136) [IAO_0000117](http://purl.obolibrary.org/obo/IAO_0000117) "person:Alan Ruttenberg"@en
-- [intermediate cell of urothelium](http://purl.obolibrary.org/obo/CL_4030055) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "
urothelial intermediate cell"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1007/978-3-030-14366-4_8"
+- [is about](http://purl.obolibrary.org/obo/IAO_0000136) [IAO_0000114](http://purl.obolibrary.org/obo/IAO_0000114) [pending final vetting](http://purl.obolibrary.org/obo/IAO_0000125)
+
+- [is about](http://purl.obolibrary.org/obo/IAO_0000136) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A (currently) primitive relation that relates an information artifact to an entity."@en
-- [intermediate cell of urothelium](http://purl.obolibrary.org/obo/CL_4030055) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A urothelial cell that is part of the regenerative layer(s) of cells directly superficial to basal cells in urothelium. The layer of intermediate cells in the urothelium ranges from one to several layers thick depending on the species with intermediate cells attached to adjacent cell layers and one another via desmosomes."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1038/s41385-022-00565-0"
+- [is about](http://purl.obolibrary.org/obo/IAO_0000136) [IAO_0000119](http://purl.obolibrary.org/obo/IAO_0000119) "Smith, Ceusters, Ruttenberg, 2000 years of philosophy"@en
-- [intermediate cell of urothelium](http://purl.obolibrary.org/obo/CL_4030055) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "It has been noted in at least some mammalian species that the urothelial intermediate cell type is similar to basal cells by expressing CK17 and (unlike umbrella cells) p63 but is positive for uroplakins (UPK) and negative for CK5. Urothelial intermediate cells have also been noted to be larger in diameter than urothelial basal cells."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1038/s41385-022-00565-0"
+- [is about](http://purl.obolibrary.org/obo/IAO_0000136) [editor note](http://purl.obolibrary.org/obo/IAO_0000116) "7/6/2009 Alan Ruttenberg. Following discussion with Jonathan Rees, and introduction of "mentions" relation. Weaken the is_about relationship to be primitive.
-- [intermediate cell of urothelium](http://purl.obolibrary.org/obo/CL_4030055) [contributor](http://purl.org/dc/terms/contributor) "https://orcid.org/0000-0003-3065-9183"
+We will try to build it back up by elaborating the various subproperties that are more precisely defined.
-- [intermediate cell of urothelium](http://purl.obolibrary.org/obo/CL_4030055) [label](http://www.w3.org/2000/01/rdf-schema#label) "intermediate cell of urothelium"
+Some currently missing phenomena that should be considered "about" are predications - "The only person who knows the answer is sitting beside me" , Allegory, Satire, and other literary forms that can be topical without explicitly mentioning the topic."@en
-- [intermediate cell of urothelium](http://purl.obolibrary.org/obo/CL_4030055) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "FMA:84155"
+- [is about](http://purl.obolibrary.org/obo/IAO_0000136) [label](http://www.w3.org/2000/01/rdf-schema#label) "is about"@en
-- Class: [intermediate cell of urothelium](http://purl.obolibrary.org/obo/CL_4030055)
+- [is about](http://purl.obolibrary.org/obo/IAO_0000136) [IAO_0000112](http://purl.obolibrary.org/obo/IAO_0000112) "This document is about information artifacts and their representations"@en
-- [intermediate cell of urothelium](http://purl.obolibrary.org/obo/CL_4030055) SubClassOf [urothelial cell](http://purl.obolibrary.org/obo/CL_0000731)
+- ObjectProperty: [is about](http://purl.obolibrary.org/obo/IAO_0000136)
-### interstitial cell of thymus `http://purl.obolibrary.org/obo/CL_4030003`
+### is active in `http://purl.obolibrary.org/obo/RO_0002432`
#### Removed
-- [interstitial cell of thymus](http://purl.obolibrary.org/obo/CL_4030003) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A cell that makes up the loose connective tissue of the thymus."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) [s41467-020-20082-7](https://www.nature.com/articles/s41467-020-20082-7)
+- [is active in](http://purl.obolibrary.org/obo/RO_0002432) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "c executes activity in d if and only if c enables p and p occurs_in d. Assuming no action at a distance by gene products, if a gene product enables (is capable of) a process that occurs in some structure, it must have at least some part in that structure."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dos"
-- [interstitial cell of thymus](http://purl.obolibrary.org/obo/CL_4030003) [contributor](http://purl.org/dc/terms/contributor) [0000-0002-1773-2692](https://orcid.org/0000-0002-1773-2692)
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:cjm"
#### Added
-- [interstitial cell of thymus](http://purl.obolibrary.org/obo/CL_4030003) [contributor](http://purl.org/dc/terms/contributor) "https://orcid.org/0000-0002-1773-2692"
+- [is active in](http://purl.obolibrary.org/obo/RO_0002432) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "c executes activity in d if and only if c enables p and p occurs_in d. Assuming no action at a distance by gene products, if a gene product enables (is capable of) a process that occurs in some structure, it must have at least some part in that structure."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) [0000-0002-7073-9172](https://orcid.org/0000-0002-7073-9172)
-- [interstitial cell of thymus](http://purl.obolibrary.org/obo/CL_4030003) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A cell that makes up the loose connective tissue of the thymus."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1038/s41467-020-20082-7"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) [0000-0002-6601-2165](https://orcid.org/0000-0002-6601-2165)
+- [is active in](http://purl.obolibrary.org/obo/RO_0002432) [see also](http://www.w3.org/2000/01/rdf-schema#seeAlso) "https://wiki.geneontology.org/Is_active_in"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI)
-### is_redundant `http://www.geneontology.org/formats/oboInOwl#is_redundant`
-#### Added
-- AnnotationProperty: [is_redundant](http://www.geneontology.org/formats/oboInOwl#is_redundant)
+### jaw region `http://purl.obolibrary.org/obo/UBERON_0011595`
+#### Removed
+- [jaw region](http://purl.obolibrary.org/obo/UBERON_0011595) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000)
-### island of Calleja `http://purl.obolibrary.org/obo/UBERON_0001881`
-#### Added
-- [island of Calleja](http://purl.obolibrary.org/obo/UBERON_0001881) [id](http://www.geneontology.org/formats/oboInOwl#id) "UBERON:0001881"
+### jaw skeleton `http://purl.obolibrary.org/obo/UBERON_0001708`
+#### Removed
+- [jaw skeleton](http://purl.obolibrary.org/obo/UBERON_0001708) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000)
+
-- [island of Calleja](http://purl.obolibrary.org/obo/UBERON_0001881) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "neuronames:276"
- - [source](http://www.geneontology.org/formats/oboInOwl#source) "BIRNLEX:1113"
-- [island of Calleja](http://purl.obolibrary.org/obo/UBERON_0001881) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "BAMS:IClj"
+### jejunum `http://purl.obolibrary.org/obo/UBERON_0002115`
+#### Removed
+- [jejunum](http://purl.obolibrary.org/obo/UBERON_0002115) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
-- [island of Calleja](http://purl.obolibrary.org/obo/UBERON_0001881) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "UMLS:C0262264"
- - [source](http://www.geneontology.org/formats/oboInOwl#source) "BIRNLEX:1113"
-- [island of Calleja](http://purl.obolibrary.org/obo/UBERON_0001881) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "insula callejae"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Wikipedia:Islands_of_Calleja"
+### juxtaglomerular apparatus `http://purl.obolibrary.org/obo/UBERON_0002303`
+#### Removed
+- [juxtaglomerular apparatus](http://purl.obolibrary.org/obo/UBERON_0002303) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [LATIN](http://purl.obolibrary.org/obo/uberon/core#LATIN)
-- [island of Calleja](http://purl.obolibrary.org/obo/UBERON_0001881) [depicted by](http://xmlns.com/foaf/0.1/depicted_by) "http://upload.wikimedia.org/wikipedia/commons/c/c0/Islands_of_Calleja_Rat.jpg"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI)
-- [island of Calleja](http://purl.obolibrary.org/obo/UBERON_0001881) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "FMA:61888"
+### kidney arcuate artery `http://purl.obolibrary.org/obo/UBERON_0001552`
+#### Removed
+- [kidney arcuate artery](http://purl.obolibrary.org/obo/UBERON_0001552) [depicted by](http://xmlns.com/foaf/0.1/depicted_by) "http://upload.wikimedia.org/wikipedia/commons/e/ee/Gray553.png"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI)
-- [island of Calleja](http://purl.obolibrary.org/obo/UBERON_0001881) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "BAMS:ICj"
+#### Added
+- [kidney arcuate artery](http://purl.obolibrary.org/obo/UBERON_0001552) [depicted by](http://xmlns.com/foaf/0.1/depicted_by) "https://upload.wikimedia.org/wikipedia/commons/8/87/2610_The_Kidney.jpg"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI)
-- [island of Calleja](http://purl.obolibrary.org/obo/UBERON_0001881) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "BM:Tel-ISC"
-- [island of Calleja](http://purl.obolibrary.org/obo/UBERON_0001881) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "BAMS:isl"
+### kidney interstitium `http://purl.obolibrary.org/obo/UBERON_0005215`
+#### Removed
+- [kidney interstitium](http://purl.obolibrary.org/obo/UBERON_0005215) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [island of Calleja](http://purl.obolibrary.org/obo/UBERON_0001881) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "EMAPA:35452"
-- [island of Calleja](http://purl.obolibrary.org/obo/UBERON_0001881) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [uberon_slim](http://purl.obolibrary.org/obo/uberon/core#uberon_slim)
-- [island of Calleja](http://purl.obolibrary.org/obo/UBERON_0001881) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "islands of Calleja"
+### kidney mesenchyme `http://purl.obolibrary.org/obo/UBERON_0003918`
+#### Removed
+- [kidney mesenchyme](http://purl.obolibrary.org/obo/UBERON_0003918) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [island of Calleja](http://purl.obolibrary.org/obo/UBERON_0001881) [UBPROP_0000008](http://purl.obolibrary.org/obo/UBPROP_0000008) "The islands of Calleja are located within the olfactory tubercle in most species; however, in primates these islands are located within the nucleus accumbens, since the olfactory tubercle is absent or extremely rudimentary in the brains of primates"
- - [source](http://www.geneontology.org/formats/oboInOwl#source) "MP:0010010"
-- [island of Calleja](http://purl.obolibrary.org/obo/UBERON_0001881) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "DHBA:10358"
-- [island of Calleja](http://purl.obolibrary.org/obo/UBERON_0001881) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "uberon"
+### kidney nerve cell `http://purl.obolibrary.org/obo/CL_1000606`
+#### Removed
+- [kidney nerve cell](http://purl.obolibrary.org/obo/CL_1000606) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [island of Calleja](http://purl.obolibrary.org/obo/UBERON_0001881) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GAID:632"
-- [island of Calleja](http://purl.obolibrary.org/obo/UBERON_0001881) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "BAMS:ISC"
-- [island of Calleja](http://purl.obolibrary.org/obo/UBERON_0001881) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "islands of Calleja (olfactory tubercle)"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "NeuroNames:276"
+### kidney rudiment `http://purl.obolibrary.org/obo/UBERON_0005095`
+#### Removed
+- [kidney rudiment](http://purl.obolibrary.org/obo/UBERON_0005095) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [island of Calleja](http://purl.obolibrary.org/obo/UBERON_0001881) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "MA:0000977"
-- [island of Calleja](http://purl.obolibrary.org/obo/UBERON_0001881) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "BIRNLEX:1113"
-- [island of Calleja](http://purl.obolibrary.org/obo/UBERON_0001881) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [pheno_slim](http://purl.obolibrary.org/obo/uberon/core#pheno_slim)
+### killer cell lectin-like receptor subfamily B member 1 `http://purl.obolibrary.org/obo/PR_000025670`
-- [island of Calleja](http://purl.obolibrary.org/obo/UBERON_0001881) [label](http://www.w3.org/2000/01/rdf-schema#label) "island of Calleja"
+#### Added
+- [killer cell lectin-like receptor subfamily B member 1](http://purl.obolibrary.org/obo/PR_000025670) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [killer cell lectin-like receptor subfamily B member 1 (human)](http://purl.obolibrary.org/obo/PR_Q12918)
-- [island of Calleja](http://purl.obolibrary.org/obo/UBERON_0001881) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PBA:10095"
-- [island of Calleja](http://purl.obolibrary.org/obo/UBERON_0001881) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "One of the seven small groups of granule cells in the polymorph layer of the olfactory tubercle and one large group, the insula magna, which lies along the border between septum, nucleus accumbens and nucleus of the diagonal band."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "MP:0010010"
+### killer cell lectin-like receptor subfamily G member 1 `http://purl.obolibrary.org/obo/PR_000009426`
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:80412"
+#### Added
+- [killer cell lectin-like receptor subfamily G member 1](http://purl.obolibrary.org/obo/PR_000009426) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [killer cell lectin-like receptor subfamily G member 1 (human)](http://purl.obolibrary.org/obo/PR_Q96E93)
-- [island of Calleja](http://purl.obolibrary.org/obo/UBERON_0001881) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "MESH:D020670"
-- [island of Calleja](http://purl.obolibrary.org/obo/UBERON_0001881) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Wikipedia:Islands_of_Calleja"
+### knee joint `http://purl.obolibrary.org/obo/UBERON_0001485`
+#### Removed
+- [knee joint](http://purl.obolibrary.org/obo/UBERON_0001485) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [island of Calleja](http://purl.obolibrary.org/obo/UBERON_0001881) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "Calleja island"
-- [island of Calleja](http://purl.obolibrary.org/obo/UBERON_0001881) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "HBA:265504792"
-- [island of Calleja](http://purl.obolibrary.org/obo/UBERON_0001881) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "insulae olfactoriae"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Wikipedia:Islands_of_Calleja"
+### koniocellular cell `http://purl.obolibrary.org/obo/CL_4023187`
+#### Removed
+- [koniocellular cell](http://purl.obolibrary.org/obo/CL_4023187) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [LATIN](http://purl.obolibrary.org/obo/uberon/core#LATIN)
-- [island of Calleja](http://purl.obolibrary.org/obo/UBERON_0001881) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "MBA:481"
-- Class: [island of Calleja](http://purl.obolibrary.org/obo/UBERON_0001881)
+### lacrimal apparatus `http://purl.obolibrary.org/obo/UBERON_0001750`
+#### Removed
+- [lacrimal apparatus](http://purl.obolibrary.org/obo/UBERON_0001750) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-- [island of Calleja](http://purl.obolibrary.org/obo/UBERON_0001881) SubClassOf [contributes to morphology of](http://purl.obolibrary.org/obo/RO_0002433) some [nucleus accumbens](http://purl.obolibrary.org/obo/UBERON_0001882)
-- [island of Calleja](http://purl.obolibrary.org/obo/UBERON_0001881) SubClassOf [telencephalic nucleus](http://purl.obolibrary.org/obo/UBERON_0009663)
-- [island of Calleja](http://purl.obolibrary.org/obo/UBERON_0001881) SubClassOf [contributes to morphology of](http://purl.obolibrary.org/obo/RO_0002433) some [olfactory tubercle](http://purl.obolibrary.org/obo/UBERON_0001883)
+### lacrimal nerve `http://purl.obolibrary.org/obo/UBERON_0011096`
+#### Removed
+- [lacrimal nerve](http://purl.obolibrary.org/obo/UBERON_0011096) SubClassOf [neuron projection bundle](http://purl.obolibrary.org/obo/CARO_0001001)
-- [island of Calleja](http://purl.obolibrary.org/obo/UBERON_0001881) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [cerebral hemisphere](http://purl.obolibrary.org/obo/UBERON_0001869)
-### lamellar body `http://purl.obolibrary.org/obo/GO_0042599`
+### lactosylceramide 4-alpha-galactosyltransferase `http://purl.obolibrary.org/obo/PR_000003516`
#### Added
-- [lamellar body](http://purl.obolibrary.org/obo/GO_0042599) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A membrane-bounded organelle, specialized for the storage and secretion of various substances (surfactant phospholipids, glycoproteins and acid phosphates) which are arranged in the form of tightly packed, concentric, membrane sheets or lamellae. Has some similar properties to, but is distinct from, a lysosome."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:jl"
+- [lactosylceramide 4-alpha-galactosyltransferase](http://purl.obolibrary.org/obo/PR_000003516) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [lactosylceramide 4-alpha-galactosyltransferase (human)](http://purl.obolibrary.org/obo/PR_Q9NPC4)
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:cjm"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Wikipedia:Lamellar_granule"
+### lactotransferrin `http://purl.obolibrary.org/obo/PR_000009978`
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:12243725"
+#### Added
+- [lactotransferrin](http://purl.obolibrary.org/obo/PR_000009978) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [lactotransferrin (human)](http://purl.obolibrary.org/obo/PR_P02788)
-- [lamellar body](http://purl.obolibrary.org/obo/GO_0042599) [label](http://www.w3.org/2000/01/rdf-schema#label) "lamellar body"
-- [lamellar body](http://purl.obolibrary.org/obo/GO_0042599) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "membrane-coating granule"
+### lamp5 GABAergic cortical interneuron `http://purl.obolibrary.org/obo/CL_4023011`
-- [lamellar body](http://purl.obolibrary.org/obo/GO_0042599) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "cellular_component"
+#### Added
+- [lamp5 GABAergic cortical interneuron](http://purl.obolibrary.org/obo/CL_4023011) [symbol](http://purl.obolibrary.org/obo/IAO_0000028) "Lamp5 cortical interneuron"
-- [lamellar body](http://purl.obolibrary.org/obo/GO_0042599) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "keratinosome"
-- [lamellar body](http://purl.obolibrary.org/obo/GO_0042599) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "Odland body"
+### laryngeal apparatus `http://purl.obolibrary.org/obo/UBERON_0010212`
+#### Removed
+- [laryngeal apparatus](http://purl.obolibrary.org/obo/UBERON_0010212) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-- [lamellar body](http://purl.obolibrary.org/obo/GO_0042599) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0042599"
-- [lamellar body](http://purl.obolibrary.org/obo/GO_0042599) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "NIF_Subcellular:sao1379604862"
-- [lamellar body](http://purl.obolibrary.org/obo/GO_0042599) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "lamellar granule"
+### laryngeal nerve `http://purl.obolibrary.org/obo/UBERON_0035642`
+#### Removed
+- [laryngeal nerve](http://purl.obolibrary.org/obo/UBERON_0035642) SubClassOf [neuron projection bundle](http://purl.obolibrary.org/obo/CARO_0001001)
-- Class: [lamellar body](http://purl.obolibrary.org/obo/GO_0042599)
-- [lamellar body](http://purl.obolibrary.org/obo/GO_0042599) SubClassOf [secretory granule](http://purl.obolibrary.org/obo/GO_0030141)
+### larynx `http://purl.obolibrary.org/obo/UBERON_0001737`
+#### Removed
+- [larynx](http://purl.obolibrary.org/obo/UBERON_0001737) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000)
-### lamellar body membrane `http://purl.obolibrary.org/obo/GO_0097232`
-#### Added
-- [lamellar body membrane](http://purl.obolibrary.org/obo/GO_0097232) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "pr"
-- [lamellar body membrane](http://purl.obolibrary.org/obo/GO_0097232) [label](http://www.w3.org/2000/01/rdf-schema#label) "lamellar body membrane"
+### lateral line ganglion neuron `http://purl.obolibrary.org/obo/CL_2000031`
+#### Removed
+- [lateral line ganglion neuron](http://purl.obolibrary.org/obo/CL_2000031) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [lamellar body membrane](http://purl.obolibrary.org/obo/GO_0097232) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0097232"
-- [lamellar body membrane](http://purl.obolibrary.org/obo/GO_0097232) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The lipid bilayer surrounding a lamellar body. A lamellar body is a membrane-bounded organelle, specialized for the storage and secretion of various substances (surfactant phospholipids, glycoproteins and acid phosphates) which are arranged in the form of tightly packed, concentric, membrane sheets or lamellae. Has some similar properties to, but is distinct from, a lysosome."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:11940594"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:sl"
+### lateral line system `http://purl.obolibrary.org/obo/UBERON_0002540`
+#### Removed
+- [lateral line system](http://purl.obolibrary.org/obo/UBERON_0002540) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [lamellar body membrane](http://purl.obolibrary.org/obo/GO_0097232) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "cellular_component"
-- [lamellar body membrane](http://purl.obolibrary.org/obo/GO_0097232) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2012-01-26T10:28:42Z"
-- Class: [lamellar body membrane](http://purl.obolibrary.org/obo/GO_0097232)
+### lateral lingual swelling `http://purl.obolibrary.org/obo/UBERON_0006757`
+#### Removed
+- [lateral lingual swelling](http://purl.obolibrary.org/obo/UBERON_0006757) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [lamellar body membrane](http://purl.obolibrary.org/obo/GO_0097232) EquivalentTo [membrane](http://purl.obolibrary.org/obo/GO_0016020) and ([bounding layer of](http://purl.obolibrary.org/obo/RO_0002007) some [lamellar body](http://purl.obolibrary.org/obo/GO_0042599))
-- [lamellar body membrane](http://purl.obolibrary.org/obo/GO_0097232) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [lamellar body](http://purl.obolibrary.org/obo/GO_0042599)
-- [lamellar body membrane](http://purl.obolibrary.org/obo/GO_0097232) SubClassOf [secretory granule membrane](http://purl.obolibrary.org/obo/GO_0030667)
+### lateral nasal prominence `http://purl.obolibrary.org/obo/UBERON_0004067`
+#### Removed
+- [lateral nasal prominence](http://purl.obolibrary.org/obo/UBERON_0004067) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [lamellar body membrane](http://purl.obolibrary.org/obo/GO_0097232) SubClassOf [bounding layer of](http://purl.obolibrary.org/obo/RO_0002007) some [lamellar body](http://purl.obolibrary.org/obo/GO_0042599)
-### lamellocyte `http://purl.obolibrary.org/obo/CL_0000396`
+### lateral ventricle neuron `http://purl.obolibrary.org/obo/CL_1001582`
#### Removed
-- [lamellocyte](http://purl.obolibrary.org/obo/CL_0000396) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A hemocyte found in immuno-stimulated larvae."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:https://doi.org/10.1016/B978-012369493-5.50008-0"
+- [lateral ventricle neuron](http://purl.obolibrary.org/obo/CL_1001582) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-#### Added
-- [lamellocyte](http://purl.obolibrary.org/obo/CL_0000396) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A hemocyte found in immuno-stimulated larvae."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/B978-012369493-5.50008-0"
-### lateral olfactory stria `http://purl.obolibrary.org/obo/UBERON_0001888`
+### layer of muscle tissue `http://purl.obolibrary.org/obo/UBERON_0018260`
+#### Removed
+- [layer of muscle tissue](http://purl.obolibrary.org/obo/UBERON_0018260) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-#### Added
-- [lateral olfactory stria](http://purl.obolibrary.org/obo/UBERON_0001888) [depicted by](http://xmlns.com/foaf/0.1/depicted_by) "http://upload.wikimedia.org/wikipedia/commons/4/4d/Gray732.png"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI)
-- [lateral olfactory stria](http://purl.obolibrary.org/obo/UBERON_0001888) [UBPROP_0000008](http://purl.obolibrary.org/obo/UBPROP_0000008) "In mammals the fibers of the dorsal lateral olfactory tract either pass under the accessory olfactory formation, or they penetrate through it separating the internal granule cells from the output cells."
- - [source](http://www.geneontology.org/formats/oboInOwl#source) "PMID:7437895"
-- [lateral olfactory stria](http://purl.obolibrary.org/obo/UBERON_0001888) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "lateral olfactory tract"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "NeuroNames:284"
+### lens of camera-type eye `http://purl.obolibrary.org/obo/UBERON_0000965`
+#### Removed
+- [lens of camera-type eye](http://purl.obolibrary.org/obo/UBERON_0000965) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-- [lateral olfactory stria](http://purl.obolibrary.org/obo/UBERON_0001888) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "BAMS:lot"
-- [lateral olfactory stria](http://purl.obolibrary.org/obo/UBERON_0001888) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "DHBA:12075"
-- [lateral olfactory stria](http://purl.obolibrary.org/obo/UBERON_0001888) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "tractus olfactorius lateralis"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "NeuroNames:284"
+### lens placode `http://purl.obolibrary.org/obo/UBERON_0003073`
+#### Removed
+- [lens placode](http://purl.obolibrary.org/obo/UBERON_0003073) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [LATIN](http://purl.obolibrary.org/obo/uberon/core#LATIN)
-- [lateral olfactory stria](http://purl.obolibrary.org/obo/UBERON_0001888) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "neuronames:284"
- - [source](http://www.geneontology.org/formats/oboInOwl#source) "BIRNLEX:1559"
-- [lateral olfactory stria](http://purl.obolibrary.org/obo/UBERON_0001888) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "olfactory tract"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "NeuroNames:284"
+### lens vesicle `http://purl.obolibrary.org/obo/UBERON_0005426`
+#### Removed
+- [lens vesicle](http://purl.obolibrary.org/obo/UBERON_0005426) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [lateral olfactory stria](http://purl.obolibrary.org/obo/UBERON_0001888) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "uberon"
-- [lateral olfactory stria](http://purl.obolibrary.org/obo/UBERON_0001888) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "stria olfactoria lateralis"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Wikipedia:Lateral_olfactory_stria"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "NeuroNames:284"
+### leucophore `http://purl.obolibrary.org/obo/CL_0000571`
+#### Removed
+- [leucophore](http://purl.obolibrary.org/obo/CL_0000571) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [LATIN](http://purl.obolibrary.org/obo/uberon/core#LATIN)
-- [lateral olfactory stria](http://purl.obolibrary.org/obo/UBERON_0001888) [label](http://www.w3.org/2000/01/rdf-schema#label) "lateral olfactory stria"
-- [lateral olfactory stria](http://purl.obolibrary.org/obo/UBERON_0001888) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "EV:0100175"
+### leukocyte `http://purl.obolibrary.org/obo/CL_0000738`
+#### Removed
+- [leukocyte](http://purl.obolibrary.org/obo/CL_0000738) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [lateral olfactory stria](http://purl.obolibrary.org/obo/UBERON_0001888) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "lateral olfactory tract, body"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "NeuroNames:284"
-- [lateral olfactory stria](http://purl.obolibrary.org/obo/UBERON_0001888) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [uberon_slim](http://purl.obolibrary.org/obo/uberon/core#uberon_slim)
-- [lateral olfactory stria](http://purl.obolibrary.org/obo/UBERON_0001888) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "DMBA:17773"
+### leukocyte immunoglobulin-like receptor subfamily A member 4 `http://purl.obolibrary.org/obo/PR_000001398`
-- [lateral olfactory stria](http://purl.obolibrary.org/obo/UBERON_0001888) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "White matter tract that contains projections from the olfactory bulb to the olfactory cortex (Maryann Martone)."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "BIRNLEX:1559"
+#### Added
+- [leukocyte immunoglobulin-like receptor subfamily A member 4](http://purl.obolibrary.org/obo/PR_000001398) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [leukocyte immunoglobulin-like receptor subfamily A member 4 (human)](http://purl.obolibrary.org/obo/PR_P59901)
-- [lateral olfactory stria](http://purl.obolibrary.org/obo/UBERON_0001888) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "HBA:265505514"
-- [lateral olfactory stria](http://purl.obolibrary.org/obo/UBERON_0001888) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "SCTID:369107001"
+### leukosialin `http://purl.obolibrary.org/obo/PR_000001879`
-- [lateral olfactory stria](http://purl.obolibrary.org/obo/UBERON_0001888) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "BIRNLEX:1559"
+#### Added
+- [leukosialin](http://purl.obolibrary.org/obo/PR_000001879) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [leukosialin (human)](http://purl.obolibrary.org/obo/PR_P16150)
-- [lateral olfactory stria](http://purl.obolibrary.org/obo/UBERON_0001888) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [vertebrate_core](http://purl.obolibrary.org/obo/uberon/core#vertebrate_core)
-- [lateral olfactory stria](http://purl.obolibrary.org/obo/UBERON_0001888) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "FMA:61971"
+### limb connective tissue `http://purl.obolibrary.org/obo/UBERON_0003587`
+#### Removed
+- [limb connective tissue](http://purl.obolibrary.org/obo/UBERON_0003587) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [lateral olfactory stria](http://purl.obolibrary.org/obo/UBERON_0001888) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "lateral olfactory stria"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "FMA:61971"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "NeuroNames:284"
-- [lateral olfactory stria](http://purl.obolibrary.org/obo/UBERON_0001888) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "MBA:665"
+### limb segment `http://purl.obolibrary.org/obo/UBERON_0002529`
+#### Removed
+- [limb segment](http://purl.obolibrary.org/obo/UBERON_0002529) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-- [lateral olfactory stria](http://purl.obolibrary.org/obo/UBERON_0001888) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Wikipedia:Lateral_olfactory_stria"
-- [lateral olfactory stria](http://purl.obolibrary.org/obo/UBERON_0001888) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "BAMS:LDTR"
-- [lateral olfactory stria](http://purl.obolibrary.org/obo/UBERON_0001888) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "BAMS:LOTR"
+### lingual nerve `http://purl.obolibrary.org/obo/UBERON_0003721`
+#### Removed
+- [lingual nerve](http://purl.obolibrary.org/obo/UBERON_0003721) SubClassOf [neuron projection bundle](http://purl.obolibrary.org/obo/CARO_0001001)
-- [lateral olfactory stria](http://purl.obolibrary.org/obo/UBERON_0001888) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "tractus olfactorius lateralis"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ZFA:0000229"
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [LATIN](http://purl.obolibrary.org/obo/uberon/core#LATIN)
-- [lateral olfactory stria](http://purl.obolibrary.org/obo/UBERON_0001888) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "LOT"
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [ABBREVIATION](http://purl.obolibrary.org/obo/uberon/core#ABBREVIATION)
+### lingual swellings `http://purl.obolibrary.org/obo/UBERON_0006260`
+#### Removed
+- [lingual swellings](http://purl.obolibrary.org/obo/UBERON_0006260) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [lateral olfactory stria](http://purl.obolibrary.org/obo/UBERON_0001888) [id](http://www.geneontology.org/formats/oboInOwl#id) "UBERON:0001888"
-- [lateral olfactory stria](http://purl.obolibrary.org/obo/UBERON_0001888) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "BM:Tel-LOT"
-- [lateral olfactory stria](http://purl.obolibrary.org/obo/UBERON_0001888) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "lateral olfactory tract. body"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "BAMS:lot"
+### liver lobule `http://purl.obolibrary.org/obo/UBERON_0004647`
+#### Removed
+- [liver lobule](http://purl.obolibrary.org/obo/UBERON_0004647) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [lateral olfactory stria](http://purl.obolibrary.org/obo/UBERON_0001888) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "UMLS:C0152330"
- - [source](http://www.geneontology.org/formats/oboInOwl#source) "BIRNLEX:1559"
-- [lateral olfactory stria](http://purl.obolibrary.org/obo/UBERON_0001888) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "BAMS:lo"
-- Class: [lateral olfactory stria](http://purl.obolibrary.org/obo/UBERON_0001888)
+### lobar bronchus `http://purl.obolibrary.org/obo/UBERON_0002183`
-- [lateral olfactory stria](http://purl.obolibrary.org/obo/UBERON_0001888) EquivalentTo [olfactory tract](http://purl.obolibrary.org/obo/UBERON_0002265) and ([overlaps](http://purl.obolibrary.org/obo/RO_0002131) some [olfactory cortex](http://purl.obolibrary.org/obo/UBERON_0002894))
+#### Added
+- [lobar bronchus](http://purl.obolibrary.org/obo/UBERON_0002183) SubClassOf [has part](http://purl.obolibrary.org/obo/BFO_0000051) some [bronchus smooth muscle](http://purl.obolibrary.org/obo/UBERON_0004242)
-- [lateral olfactory stria](http://purl.obolibrary.org/obo/UBERON_0001888) SubClassOf [overlaps](http://purl.obolibrary.org/obo/RO_0002131) some [olfactory cortex](http://purl.obolibrary.org/obo/UBERON_0002894)
+- [lobar bronchus](http://purl.obolibrary.org/obo/UBERON_0002183) SubClassOf [has part](http://purl.obolibrary.org/obo/BFO_0000051) some [cartilage of bronchus](http://purl.obolibrary.org/obo/UBERON_0001956)
-- [lateral olfactory stria](http://purl.obolibrary.org/obo/UBERON_0001888) SubClassOf [olfactory tract linking bulb to ipsilateral dorsal telencephalon](http://purl.obolibrary.org/obo/UBERON_0034730)
+- [lobar bronchus](http://purl.obolibrary.org/obo/UBERON_0002183) SubClassOf [has part](http://purl.obolibrary.org/obo/BFO_0000051) some [bronchus submucosal gland](http://purl.obolibrary.org/obo/UBERON_8410043)
-### left putamen `http://purl.obolibrary.org/obo/UBERON_0008884`
+### located in `http://purl.obolibrary.org/obo/RO_0001025`
#### Added
-- [left putamen](http://purl.obolibrary.org/obo/UBERON_0008884) [id](http://www.geneontology.org/formats/oboInOwl#id) "UBERON:0008884"
+- [located in](http://purl.obolibrary.org/obo/RO_0001025) [see also](http://www.w3.org/2000/01/rdf-schema#seeAlso) "https://wiki.geneontology.org/Located_in"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI)
-- [left putamen](http://purl.obolibrary.org/obo/UBERON_0008884) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "FMA:72829"
-- [left putamen](http://purl.obolibrary.org/obo/UBERON_0008884) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "HBA:4288"
+### long-wave-sensitive opsin 1 `http://purl.obolibrary.org/obo/PR_000001244`
-- [left putamen](http://purl.obolibrary.org/obo/UBERON_0008884) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A putamen that is part of a left cerebral hemisphere."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "OBOL:automatic"
+#### Added
+- [long-wave-sensitive opsin 1](http://purl.obolibrary.org/obo/PR_000001244) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [long-wave-sensitive opsin 1 (human)](http://purl.obolibrary.org/obo/PR_P04000)
-- [left putamen](http://purl.obolibrary.org/obo/UBERON_0008884) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "uberon"
-- [left putamen](http://purl.obolibrary.org/obo/UBERON_0008884) [label](http://www.w3.org/2000/01/rdf-schema#label) "left putamen"
+### loose mesenchyme tissue `http://purl.obolibrary.org/obo/UBERON_0007529`
+#### Removed
+- [loose mesenchyme tissue](http://purl.obolibrary.org/obo/UBERON_0007529) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- Class: [left putamen](http://purl.obolibrary.org/obo/UBERON_0008884)
-- [left putamen](http://purl.obolibrary.org/obo/UBERON_0008884) EquivalentTo [putamen](http://purl.obolibrary.org/obo/UBERON_0001874) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [left cerebral hemisphere](http://purl.obolibrary.org/obo/UBERON_0002812))
-- [left putamen](http://purl.obolibrary.org/obo/UBERON_0008884) SubClassOf [putamen](http://purl.obolibrary.org/obo/UBERON_0001874)
+### low affinity immunoglobulin epsilon Fc receptor `http://purl.obolibrary.org/obo/PR_000001880`
-- [left putamen](http://purl.obolibrary.org/obo/UBERON_0008884) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [left cerebral hemisphere](http://purl.obolibrary.org/obo/UBERON_0002812)
+#### Added
+- [low affinity immunoglobulin epsilon Fc receptor](http://purl.obolibrary.org/obo/PR_000001880) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [low affinity immunoglobulin epsilon Fc receptor (human)](http://purl.obolibrary.org/obo/PR_P06734)
-### leukocyte `http://purl.obolibrary.org/obo/CL_0000738`
+### low affinity immunoglobulin gamma Fc region receptor II-b `http://purl.obolibrary.org/obo/PR_000001481`
#### Added
-- [leukocyte](http://purl.obolibrary.org/obo/CL_0000738) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "NCIT:C12529"
+- [low affinity immunoglobulin gamma Fc region receptor II-b](http://purl.obolibrary.org/obo/PR_000001481) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [low affinity immunoglobulin gamma Fc region receptor II-b (human)](http://purl.obolibrary.org/obo/PR_P31994)
-### liver CD103-negative dendritic cell `http://purl.obolibrary.org/obo/CL_0002505`
+### lower digestive tract `http://purl.obolibrary.org/obo/UBERON_0004907`
#### Removed
-- [liver CD103-negative dendritic cell](http://purl.obolibrary.org/obo/CL_0002505) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A CD11b-positive dendritic cell that is CD11b-high, CD45-positive, MHC-II-positive and CD103-negative."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:tfm"
+- [lower digestive tract](http://purl.obolibrary.org/obo/UBERON_0004907) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "http:http://www.immgen.org/index_content.html"
-#### Added
-- [liver CD103-negative dendritic cell](http://purl.obolibrary.org/obo/CL_0002505) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A CD11b-positive dendritic cell that is CD11b-high, CD45-positive, MHC-II-positive and CD103-negative."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:tfm"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "http://www.immgen.org/index_content.html"
+### lower jaw region `http://purl.obolibrary.org/obo/UBERON_0001710`
+#### Removed
+- [lower jaw region](http://purl.obolibrary.org/obo/UBERON_0001710) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000)
+
-### liver CD103-positive dendritic cell `http://purl.obolibrary.org/obo/CL_0002506`
+### lower leg epithelium `http://purl.obolibrary.org/obo/UBERON_0005229`
#### Removed
-- [liver CD103-positive dendritic cell](http://purl.obolibrary.org/obo/CL_0002506) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A CD11b-positive dendritic cell that is CD11b-low, CD45-positive, MHC-II-high and CD103-positive that is located in the liver."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:tfm"
+- [lower leg epithelium](http://purl.obolibrary.org/obo/UBERON_0005229) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "http:http://www.immgen.org/index_content.html"
-#### Added
-- [liver CD103-positive dendritic cell](http://purl.obolibrary.org/obo/CL_0002506) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A CD11b-positive dendritic cell that is CD11b-low, CD45-positive, MHC-II-high and CD103-positive that is located in the liver."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:tfm"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "http://www.immgen.org/index_content.html"
+### lower lip `http://purl.obolibrary.org/obo/UBERON_0001835`
+#### Removed
+- [lower lip](http://purl.obolibrary.org/obo/UBERON_0001835) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-### lobar bronchus connective tissue `http://purl.obolibrary.org/obo/UBERON_0003591`
-#### Added
-- [lobar bronchus connective tissue](http://purl.obolibrary.org/obo/UBERON_0003591) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [human_reference_atlas](http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas)
+### lower motor neuron `http://purl.obolibrary.org/obo/CL_0008039`
+#### Removed
+- [lower motor neuron](http://purl.obolibrary.org/obo/CL_0008039) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [lobar bronchus connective tissue](http://purl.obolibrary.org/obo/UBERON_0003591) [present_in_taxon](http://purl.obolibrary.org/obo/RO_0002175) [Homo sapiens](http://purl.obolibrary.org/obo/NCBITaxon_9606)
-### lobar bronchus vasculature `http://purl.obolibrary.org/obo/UBERON_0004889`
+### lower respiratory tract `http://purl.obolibrary.org/obo/UBERON_0001558`
#### Removed
-- [lobar bronchus vasculature](http://purl.obolibrary.org/obo/UBERON_0004889) [present_in_taxon](http://purl.obolibrary.org/obo/RO_0002175) [Homo sapiens](http://purl.obolibrary.org/obo/NCBITaxon_9606)
+- [lower respiratory tract](http://purl.obolibrary.org/obo/UBERON_0001558) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-- [lobar bronchus vasculature](http://purl.obolibrary.org/obo/UBERON_0004889) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [human_reference_atlas](http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas)
-
-### lobe of lung `http://purl.obolibrary.org/obo/UBERON_0000101`
+### lower urinary tract `http://purl.obolibrary.org/obo/UBERON_0001556`
#### Removed
-- [lobe of lung](http://purl.obolibrary.org/obo/UBERON_0000101) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [human_reference_atlas](http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas)
-
-- [lobe of lung](http://purl.obolibrary.org/obo/UBERON_0000101) [present_in_taxon](http://purl.obolibrary.org/obo/RO_0002175) [Homo sapiens](http://purl.obolibrary.org/obo/NCBITaxon_9606)
+- [lower urinary tract](http://purl.obolibrary.org/obo/UBERON_0001556) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-### luminal endometrial ciliated epithelial cell `http://purl.obolibrary.org/obo/CL_4030041`
+### lumbosacral nerve plexus `http://purl.obolibrary.org/obo/UBERON_0001815`
#### Removed
-- [luminal endometrial ciliated epithelial cell](http://purl.obolibrary.org/obo/CL_4030041) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A ciliated cell of the endometrial luminal epithelium."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "https://www.nature.com/articles/s41591-020-1040-z"
+- [lumbosacral nerve plexus](http://purl.obolibrary.org/obo/UBERON_0001815) SubClassOf [neuron projection bundle](http://purl.obolibrary.org/obo/CARO_0001001)
#### Added
-- [luminal endometrial ciliated epithelial cell](http://purl.obolibrary.org/obo/CL_4030041) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A ciliated cell of the endometrial luminal epithelium."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1038/s41591-020-1040-z"
+- [lumbosacral nerve plexus](http://purl.obolibrary.org/obo/UBERON_0001815) SubClassOf [neuron projection bundle](http://purl.obolibrary.org/obo/UBERON_0000122)
-### lung interstitial macrophage `http://purl.obolibrary.org/obo/CL_4033043`
+### lumen of `http://purl.obolibrary.org/obo/RO_0002571`
+#### Removed
+- [lumen of](http://purl.obolibrary.org/obo/RO_0002571) [IAO_0000119](http://purl.obolibrary.org/obo/IAO_0000119) "GOC:cjm"
#### Added
-- [lung interstitial macrophage](http://purl.obolibrary.org/obo/CL_4033043) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A macrophage that is part of the lung connective tissue (pulmonary interstitium). This cell performs tissue remodeling and contributes to barrier immunity through antigen presentation."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:35017701"
+- [lumen of](http://purl.obolibrary.org/obo/RO_0002571) [IAO_0000119](http://purl.obolibrary.org/obo/IAO_0000119) [0000-0002-6601-2165](https://orcid.org/0000-0002-6601-2165)
+
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:33382972"
+### lumen of central canal of spinal cord `http://purl.obolibrary.org/obo/UBERON_0009572`
+#### Removed
+- [lumen of central canal of spinal cord](http://purl.obolibrary.org/obo/UBERON_0009572) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:36211428"
-- [lung interstitial macrophage](http://purl.obolibrary.org/obo/CL_4033043) [date](http://purl.org/dc/terms/date) "2023-06-15T12:58:11Z"^^[dateTime](http://www.w3.org/2001/XMLSchema#dateTime)
-- [lung interstitial macrophage](http://purl.obolibrary.org/obo/CL_4033043) [label](http://www.w3.org/2000/01/rdf-schema#label) "lung interstitial macrophage"
+### lumican `http://purl.obolibrary.org/obo/PR_000009981`
-- [lung interstitial macrophage](http://purl.obolibrary.org/obo/CL_4033043) [contributor](http://purl.org/dc/terms/contributor) [0000-0001-6677-8489](https://orcid.org/0000-0001-6677-8489)
+#### Added
+- [lumican](http://purl.obolibrary.org/obo/PR_000009981) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [lumican (human)](http://purl.obolibrary.org/obo/PR_P51884)
-- [lung interstitial macrophage](http://purl.obolibrary.org/obo/CL_4033043) [contributor](http://purl.org/dc/terms/contributor) [0000-0002-9185-3994](https://orcid.org/0000-0002-9185-3994)
-- [lung interstitial macrophage](http://purl.obolibrary.org/obo/CL_4033043) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "lung IM"
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
+### luminal epithelial cell of mammary gland `http://purl.obolibrary.org/obo/CL_0002326`
+#### Removed
+- [luminal epithelial cell of mammary gland](http://purl.obolibrary.org/obo/CL_0002326) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:36211428"
-- Class: [lung interstitial macrophage](http://purl.obolibrary.org/obo/CL_4033043)
-- [lung interstitial macrophage](http://purl.obolibrary.org/obo/CL_4033043) SubClassOf [tissue-resident macrophage](http://purl.obolibrary.org/obo/CL_0000864)
+### lung bud `http://purl.obolibrary.org/obo/UBERON_0000118`
+#### Removed
+- [lung bud](http://purl.obolibrary.org/obo/UBERON_0000118) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [lung interstitial macrophage](http://purl.obolibrary.org/obo/CL_4033043) SubClassOf [connective tissue cell](http://purl.obolibrary.org/obo/CL_0002320)
-- [lung interstitial macrophage](http://purl.obolibrary.org/obo/CL_4033043) SubClassOf [lung macrophage](http://purl.obolibrary.org/obo/CL_1001603)
-- [lung interstitial macrophage](http://purl.obolibrary.org/obo/CL_4033043) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [lung connective tissue](http://purl.obolibrary.org/obo/UBERON_0000114)
+### lung epithelium `http://purl.obolibrary.org/obo/UBERON_0000115`
+#### Removed
+- [lung epithelium](http://purl.obolibrary.org/obo/UBERON_0000115) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-### lung migratory dendritic cell `http://purl.obolibrary.org/obo/CL_4033045`
-#### Added
-- [lung migratory dendritic cell](http://purl.obolibrary.org/obo/CL_4033045) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "lung mDCs"
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
+### lung field `http://purl.obolibrary.org/obo/UBERON_0022361`
+#### Removed
+- [lung field](http://purl.obolibrary.org/obo/UBERON_0022361) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [plural term](http://purl.obolibrary.org/obo/uberon#PLURAL)
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:34516781"
-- [lung migratory dendritic cell](http://purl.obolibrary.org/obo/CL_4033045) [date](http://purl.org/dc/terms/date) "2023-06-21T10:04:46Z"^^[dateTime](http://www.w3.org/2001/XMLSchema#dateTime)
+### lung megakaryocyte `http://purl.obolibrary.org/obo/CL_4033018`
-- [lung migratory dendritic cell](http://purl.obolibrary.org/obo/CL_4033045) [contributor](http://purl.org/dc/terms/contributor) [0000-0002-9185-3994](https://orcid.org/0000-0002-9185-3994)
+#### Added
+- [lung megakaryocyte](http://purl.obolibrary.org/obo/CL_4033018) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "lung-resident megakaryocyte"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:36524131"
-- [lung migratory dendritic cell](http://purl.obolibrary.org/obo/CL_4033045) [label](http://www.w3.org/2000/01/rdf-schema#label) "lung migratory dendritic cell"
+- [lung megakaryocyte](http://purl.obolibrary.org/obo/CL_4033018) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "lung resident megakaryocyte"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:36524131"
-- [lung migratory dendritic cell](http://purl.obolibrary.org/obo/CL_4033045) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "lung mDC"
+- [lung megakaryocyte](http://purl.obolibrary.org/obo/CL_4033018) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "MKL"
- [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:34516781"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:36524131"
-- [lung migratory dendritic cell](http://purl.obolibrary.org/obo/CL_4033045) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A dendritic cell that captures antigens in a lung and migrates to a lymph node or to the spleen to activate T cells."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:34516781"
+- [lung megakaryocyte](http://purl.obolibrary.org/obo/CL_4033018) EquivalentTo [megakaryocyte](http://purl.obolibrary.org/obo/CL_0000556) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [lung connective tissue](http://purl.obolibrary.org/obo/UBERON_0000114))
-- [lung migratory dendritic cell](http://purl.obolibrary.org/obo/CL_4033045) [contributor](http://purl.org/dc/terms/contributor) [0000-0001-6677-8489](https://orcid.org/0000-0001-6677-8489)
+- [lung megakaryocyte](http://purl.obolibrary.org/obo/CL_4033018) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [lung connective tissue](http://purl.obolibrary.org/obo/UBERON_0000114)
-- Class: [lung migratory dendritic cell](http://purl.obolibrary.org/obo/CL_4033045)
+- [lung megakaryocyte](http://purl.obolibrary.org/obo/CL_4033018) SubClassOf [connective tissue cell](http://purl.obolibrary.org/obo/CL_0002320)
-- [lung migratory dendritic cell](http://purl.obolibrary.org/obo/CL_4033045) SubClassOf [dendritic cell](http://purl.obolibrary.org/obo/CL_0000451)
+### lung primordium `http://purl.obolibrary.org/obo/UBERON_0005597`
+#### Removed
+- [lung primordium](http://purl.obolibrary.org/obo/UBERON_0005597) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-### lung resident memory CD8-positive, CD103-positive, alpha-beta T cell `http://purl.obolibrary.org/obo/CL_4033040`
-#### Added
-- [lung resident memory CD8-positive, CD103-positive, alpha-beta T cell](http://purl.obolibrary.org/obo/CL_4033040) [contributor](http://purl.org/dc/terms/contributor) [0000-0001-6677-8489](https://orcid.org/0000-0001-6677-8489)
-- [lung resident memory CD8-positive, CD103-positive, alpha-beta T cell](http://purl.obolibrary.org/obo/CL_4033040) [label](http://www.w3.org/2000/01/rdf-schema#label) "lung resident memory CD8-positive, CD103-positive, alpha-beta T cell"
+### lymph `http://purl.obolibrary.org/obo/UBERON_0002391`
+#### Removed
+- [lymph](http://purl.obolibrary.org/obo/UBERON_0002391) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [lung resident memory CD8-positive, CD103-positive, alpha-beta T cell](http://purl.obolibrary.org/obo/CL_4033040) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A lung resident memory CD8-positive, alpha-beta T cell that is CD103-positive."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:27776108"
-- [lung resident memory CD8-positive, CD103-positive, alpha-beta T cell](http://purl.obolibrary.org/obo/CL_4033040) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "lung TRM CD8-positive, CD103-positive cell"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:27776108"
-- [lung resident memory CD8-positive, CD103-positive, alpha-beta T cell](http://purl.obolibrary.org/obo/CL_4033040) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "lung TRM CD8-positive, integrin alpha E-positive cell"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:27776108"
+### lymph node macrophage `http://purl.obolibrary.org/obo/CL_0000868`
+#### Removed
+- [lymph node macrophage](http://purl.obolibrary.org/obo/CL_0000868) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-- [lung resident memory CD8-positive, CD103-positive, alpha-beta T cell](http://purl.obolibrary.org/obo/CL_4033040) [date](http://purl.org/dc/terms/date) "2023-05-24T12:23:35Z"^^[dateTime](http://www.w3.org/2001/XMLSchema#dateTime)
-- [lung resident memory CD8-positive, CD103-positive, alpha-beta T cell](http://purl.obolibrary.org/obo/CL_4033040) [contributor](http://purl.org/dc/terms/contributor) [0000-0002-9185-3994](https://orcid.org/0000-0002-9185-3994)
-- [lung resident memory CD8-positive, CD103-positive, alpha-beta T cell](http://purl.obolibrary.org/obo/CL_4033040) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "lung resident memory CD8-positive CD103-positive, alpha-beta T cell"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:27776108"
+### lymph vasculature `http://purl.obolibrary.org/obo/UBERON_0004536`
+#### Removed
+- [lymph vasculature](http://purl.obolibrary.org/obo/UBERON_0004536) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- Class: [lung resident memory CD8-positive, CD103-positive, alpha-beta T cell](http://purl.obolibrary.org/obo/CL_4033040)
-- [lung resident memory CD8-positive, CD103-positive, alpha-beta T cell](http://purl.obolibrary.org/obo/CL_4033040) EquivalentTo [lung resident memory CD8-positive, alpha-beta T cell](http://purl.obolibrary.org/obo/CL_4033039) and ([has plasma membrane part](http://purl.obolibrary.org/obo/RO_0002104) some [integrin alpha-E](http://purl.obolibrary.org/obo/PR_000001010))
-- [lung resident memory CD8-positive, CD103-positive, alpha-beta T cell](http://purl.obolibrary.org/obo/CL_4033040) SubClassOf [lung resident memory CD8-positive, alpha-beta T cell](http://purl.obolibrary.org/obo/CL_4033039)
+### lymphatic vessel `http://purl.obolibrary.org/obo/UBERON_0001473`
+#### Removed
+- [lymphatic vessel](http://purl.obolibrary.org/obo/UBERON_0001473) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [lung resident memory CD8-positive, CD103-positive, alpha-beta T cell](http://purl.obolibrary.org/obo/CL_4033040) SubClassOf [has plasma membrane part](http://purl.obolibrary.org/obo/RO_0002104) some [integrin alpha-E](http://purl.obolibrary.org/obo/PR_000001010)
-### macrophage `http://purl.obolibrary.org/obo/CL_0000235`
+### lymphocyte antigen 75 `http://purl.obolibrary.org/obo/PR_000001026`
#### Added
-- [macrophage](http://purl.obolibrary.org/obo/CL_0000235) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [general_cell_types_upper_slim](http://purl.obolibrary.org/obo/cl#general_cell_types_upper_slim)
+- [lymphocyte antigen 75](http://purl.obolibrary.org/obo/PR_000001026) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [lymphocyte antigen 75 (human)](http://purl.obolibrary.org/obo/PR_000034294)
-### matrix D1 medium spiny neuron `http://purl.obolibrary.org/obo/CL_4030043`
+### lymphocyte of B lineage, CD19-positive `http://purl.obolibrary.org/obo/CL_0001200`
+#### Removed
+- [lymphocyte of B lineage, CD19-positive](http://purl.obolibrary.org/obo/CL_0001200) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-#### Added
-- [matrix D1 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030043) [date](http://purl.org/dc/terms/date) "2023-06-02T14:05:03Z"^^[dateTime](http://www.w3.org/2001/XMLSchema#dateTime)
-- [matrix D1 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030043) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "D1M"
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) [j.cub.2021.10.015](DOI:10.1016/j.cub.2021.10.015)
+### lymphoid tissue `http://purl.obolibrary.org/obo/UBERON_0001744`
+#### Removed
+- [lymphoid tissue](http://purl.obolibrary.org/obo/UBERON_0001744) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [matrix D1 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030043) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "D1-matrix"
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) [j.cub.2021.10.015](DOI:10.1016/j.cub.2021.10.015)
-- [matrix D1 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030043) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "matrix D1-MSN"
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
+### lymphoid tissue–inducer cell `http://purl.obolibrary.org/obo/CL_0011018`
+#### Removed
+- [lymphoid tissue–inducer cell](http://purl.obolibrary.org/obo/CL_0011018) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) [j.cub.2021.10.015](DOI:10.1016/j.cub.2021.10.015)
-- [matrix D1 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030043) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A DRD1-expressing medium spiny neuron that is part of a matrix compartment of dorsal striatum."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) [j.cub.2021.10.015](DOI:10.1016/j.cub.2021.10.015)
-- [matrix D1 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030043) [label](http://www.w3.org/2000/01/rdf-schema#label) "matrix D1 medium spiny neuron"
+### lysosome-associated membrane glycoprotein 5 `http://purl.obolibrary.org/obo/PR_000032148`
+
+#### Added
+- [lysosome-associated membrane glycoprotein 5](http://purl.obolibrary.org/obo/PR_000032148) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [lysosome-associated membrane glycoprotein 5 (human)](http://purl.obolibrary.org/obo/PR_Q9UJQ1)
-- [matrix D1 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030043) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "In Rhesus macaques, both matrix D1 and D2 medium spiny neuron cell types have been noted to have enriched gene expression of the following: EPHA4, GDA, STXBP6, and SEMA3E. Broadly understood, matrix MSNs receive neocortical inputs from the associative and sensorimotor cortex and give rise to the direct and indirect pathways."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) [j.cub.2021.10.015](DOI:10.1016/j.cub.2021.10.015)
-- Class: [matrix D1 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030043)
+### macroglial cell `http://purl.obolibrary.org/obo/CL_0000126`
-- [matrix D1 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030043) SubClassOf [direct pathway medium spiny neuron](http://purl.obolibrary.org/obo/CL_4023026)
+#### Added
+- [macroglial cell](http://purl.obolibrary.org/obo/CL_0000126) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "macroglia"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [plural term](http://purl.obolibrary.org/obo/uberon#PLURAL)
-- [matrix D1 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030043) SubClassOf [has soma location](http://purl.obolibrary.org/obo/RO_0002100) some
-([matrix compartment](http://purl.obolibrary.org/obo/UBERON_0027368) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [dorsal striatum](http://purl.obolibrary.org/obo/UBERON_0005382)))
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1152/physrev.2001.81.2.871"
-### matrix D2 medium spiny neuron `http://purl.obolibrary.org/obo/CL_4030047`
+### macrophage colony-stimulating factor 1 receptor `http://purl.obolibrary.org/obo/PR_000002062`
#### Added
-- [matrix D2 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030047) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "D2-matrix"
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
+- [macrophage colony-stimulating factor 1 receptor](http://purl.obolibrary.org/obo/PR_000002062) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [macrophage colony-stimulating factor 1 receptor (human)](http://purl.obolibrary.org/obo/PR_P07333)
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) [j.cub.2021.10.015](DOI:10.1016/j.cub.2021.10.015)
-- [matrix D2 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030047) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "D2M"
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
+### macrophage derived foam cell `http://purl.obolibrary.org/obo/CL_0000517`
+#### Removed
+- [macrophage derived foam cell](http://purl.obolibrary.org/obo/CL_0000517) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) [j.cub.2021.10.015](DOI:10.1016/j.cub.2021.10.015)
-- [matrix D2 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030047) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "matrix D2-MSN"
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) [j.cub.2021.10.015](DOI:10.1016/j.cub.2021.10.015)
+### macrophage mannose receptor 1 `http://purl.obolibrary.org/obo/PR_000002972`
-- [matrix D2 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030047) [label](http://www.w3.org/2000/01/rdf-schema#label) "matrix D2 medium spiny neuron"
+#### Added
+- [macrophage mannose receptor 1](http://purl.obolibrary.org/obo/PR_000002972) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [macrophage mannose receptor 1 (human)](http://purl.obolibrary.org/obo/PR_P22897)
-- [matrix D2 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030047) [date](http://purl.org/dc/terms/date) "2023-06-02T14:40:25Z"^^[dateTime](http://www.w3.org/2001/XMLSchema#dateTime)
-- [matrix D2 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030047) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A DRD2-expressing medium spiny neuron that is part of a matrix compartment of dorsal striatum."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) [j.cub.2021.10.015](DOI:10.1016/j.cub.2021.10.015)
+### macrophage receptor MARCO `http://purl.obolibrary.org/obo/PR_000001884`
-- [matrix D2 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030047) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "In Rhesus macaques, both matrix D1 and D2 medium spiny neuron cell types have been noted to have enriched gene expression of the following: EPHA4, GDA, STXBP6, and SEMA3E. Broadly understood, matrix MSNs receive neocortical inputs from the associative and sensorimotor cortex and give rise to the direct and indirect pathways."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) [j.cub.2021.10.015](DOI:10.1016/j.cub.2021.10.015)
+#### Added
+- [macrophage receptor MARCO](http://purl.obolibrary.org/obo/PR_000001884) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [macrophage receptor MARCO (human)](http://purl.obolibrary.org/obo/PR_Q9UEW3)
-- Class: [matrix D2 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030047)
-- [matrix D2 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030047) SubClassOf [has soma location](http://purl.obolibrary.org/obo/RO_0002100) some
-([matrix compartment](http://purl.obolibrary.org/obo/UBERON_0027368) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [dorsal striatum](http://purl.obolibrary.org/obo/UBERON_0005382)))
+### macrophage scavenger receptor types I and II `http://purl.obolibrary.org/obo/PR_000001885`
-- [matrix D2 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030047) SubClassOf [indirect pathway medium spiny neuron](http://purl.obolibrary.org/obo/CL_4023029)
+#### Added
+- [macrophage scavenger receptor types I and II](http://purl.obolibrary.org/obo/PR_000001885) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [macrophage scavenger receptor types I and II (human)](http://purl.obolibrary.org/obo/PR_P21757)
-### matrix compartment `http://purl.obolibrary.org/obo/UBERON_0027368`
+### macrosialin `http://purl.obolibrary.org/obo/PR_000002064`
#### Added
-- [matrix compartment](http://purl.obolibrary.org/obo/UBERON_0027368) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "matrix compartment"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "NLXANAT:20090503"
-
-- [matrix compartment](http://purl.obolibrary.org/obo/UBERON_0027368) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "NLXANAT:20090503"
+- [macrosialin](http://purl.obolibrary.org/obo/PR_000002064) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [macrosialin (human)](http://purl.obolibrary.org/obo/PR_P34810)
-- [matrix compartment](http://purl.obolibrary.org/obo/UBERON_0027368) [label](http://www.w3.org/2000/01/rdf-schema#label) "matrix compartment"
-- [matrix compartment](http://purl.obolibrary.org/obo/UBERON_0027368) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The larger of two chemoarchitectural compartments identified in the neostriatum through differential staining for various biochemical markers. It usually is identified through differentially high staining for acetylcholinesterase and calbinin D28K."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "NLXANAT:20090503"
+### magnocellular layer of dorsal nucleus of lateral geniculate body `http://purl.obolibrary.org/obo/UBERON_0013606`
+#### Removed
+- [magnocellular layer of dorsal nucleus of lateral geniculate body](http://purl.obolibrary.org/obo/UBERON_0013606) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [matrix compartment](http://purl.obolibrary.org/obo/UBERON_0027368) [id](http://www.geneontology.org/formats/oboInOwl#id) "UBERON:0027368"
-- [matrix compartment](http://purl.obolibrary.org/obo/UBERON_0027368) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "matrix"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "NLXANAT:20090503"
-- [matrix compartment](http://purl.obolibrary.org/obo/UBERON_0027368) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "uberon"
+### mammary gland connective tissue `http://purl.obolibrary.org/obo/UBERON_0003584`
+#### Removed
+- [mammary gland connective tissue](http://purl.obolibrary.org/obo/UBERON_0003584) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- Class: [matrix compartment](http://purl.obolibrary.org/obo/UBERON_0027368)
-- [matrix compartment](http://purl.obolibrary.org/obo/UBERON_0027368) SubClassOf [chemoarchitectural part of striatum](http://purl.obolibrary.org/obo/UBERON_0025736)
- - [source](http://www.geneontology.org/formats/oboInOwl#source) "NIFSTD"
+### mammary placode `http://purl.obolibrary.org/obo/UBERON_0005311`
+#### Removed
+- [mammary placode](http://purl.obolibrary.org/obo/UBERON_0005311) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-### matrix compartment of caudate nucleus `http://purl.obolibrary.org/obo/UBERON_0029001`
-#### Added
-- [matrix compartment of caudate nucleus](http://purl.obolibrary.org/obo/UBERON_0029001) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "uberon"
-- [matrix compartment of caudate nucleus](http://purl.obolibrary.org/obo/UBERON_0029001) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Matrix compartment located in the caudate nucleus."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "NLXANAT:20090504"
+### mammillary body neuron `http://purl.obolibrary.org/obo/CL_4023074`
+#### Removed
+- [mammillary body neuron](http://purl.obolibrary.org/obo/CL_4023074) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [matrix compartment of caudate nucleus](http://purl.obolibrary.org/obo/UBERON_0029001) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "matrix compartment of caudate nucleus"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "NLXANAT:20090504"
-- [matrix compartment of caudate nucleus](http://purl.obolibrary.org/obo/UBERON_0029001) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "NLXANAT:20090504"
-- [matrix compartment of caudate nucleus](http://purl.obolibrary.org/obo/UBERON_0029001) [label](http://www.w3.org/2000/01/rdf-schema#label) "matrix compartment of caudate nucleus"
+### mandibular prominence `http://purl.obolibrary.org/obo/UBERON_0005867`
+#### Removed
+- [mandibular prominence](http://purl.obolibrary.org/obo/UBERON_0005867) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [matrix compartment of caudate nucleus](http://purl.obolibrary.org/obo/UBERON_0029001) [id](http://www.geneontology.org/formats/oboInOwl#id) "UBERON:0029001"
-- Class: [matrix compartment of caudate nucleus](http://purl.obolibrary.org/obo/UBERON_0029001)
-- [matrix compartment of caudate nucleus](http://purl.obolibrary.org/obo/UBERON_0029001) EquivalentTo [matrix compartment](http://purl.obolibrary.org/obo/UBERON_0027368) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [caudate nucleus](http://purl.obolibrary.org/obo/UBERON_0001873))
+### manual digit epithelium `http://purl.obolibrary.org/obo/UBERON_0005227`
+#### Removed
+- [manual digit epithelium](http://purl.obolibrary.org/obo/UBERON_0005227) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [matrix compartment of caudate nucleus](http://purl.obolibrary.org/obo/UBERON_0029001) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [caudate nucleus](http://purl.obolibrary.org/obo/UBERON_0001873)
-- [matrix compartment of caudate nucleus](http://purl.obolibrary.org/obo/UBERON_0029001) SubClassOf [matrix compartment](http://purl.obolibrary.org/obo/UBERON_0027368)
+### manual digit mesenchyme `http://purl.obolibrary.org/obo/UBERON_0005257`
+#### Removed
+- [manual digit mesenchyme](http://purl.obolibrary.org/obo/UBERON_0005257) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-### matrix compartment of putamen `http://purl.obolibrary.org/obo/UBERON_0029002`
-#### Added
-- [matrix compartment of putamen](http://purl.obolibrary.org/obo/UBERON_0029002) [id](http://www.geneontology.org/formats/oboInOwl#id) "UBERON:0029002"
-- [matrix compartment of putamen](http://purl.obolibrary.org/obo/UBERON_0029002) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "matrix compartment of putamen"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "NLXANAT:20090505"
+### mast cell `http://purl.obolibrary.org/obo/CL_0000097`
+#### Removed
+- [mast cell](http://purl.obolibrary.org/obo/CL_0000097) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-- [matrix compartment of putamen](http://purl.obolibrary.org/obo/UBERON_0029002) [label](http://www.w3.org/2000/01/rdf-schema#label) "matrix compartment of putamen"
-- [matrix compartment of putamen](http://purl.obolibrary.org/obo/UBERON_0029002) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "uberon"
-- [matrix compartment of putamen](http://purl.obolibrary.org/obo/UBERON_0029002) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "NLXANAT:20090505"
+### mast cell progenitor `http://purl.obolibrary.org/obo/CL_0000831`
+#### Removed
+- [mast cell progenitor](http://purl.obolibrary.org/obo/CL_0000831) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-- Class: [matrix compartment of putamen](http://purl.obolibrary.org/obo/UBERON_0029002)
-- [matrix compartment of putamen](http://purl.obolibrary.org/obo/UBERON_0029002) EquivalentTo [matrix compartment](http://purl.obolibrary.org/obo/UBERON_0027368) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [putamen](http://purl.obolibrary.org/obo/UBERON_0001874))
-- [matrix compartment of putamen](http://purl.obolibrary.org/obo/UBERON_0029002) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [putamen](http://purl.obolibrary.org/obo/UBERON_0001874)
+### mature T cell `http://purl.obolibrary.org/obo/CL_0002419`
+#### Removed
+- [mature T cell](http://purl.obolibrary.org/obo/CL_0002419) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-- [matrix compartment of putamen](http://purl.obolibrary.org/obo/UBERON_0029002) SubClassOf [matrix compartment](http://purl.obolibrary.org/obo/UBERON_0027368)
-### mature CD8 single-positive thymocyte `http://purl.obolibrary.org/obo/CL_0002437`
+### maxillary prominence `http://purl.obolibrary.org/obo/UBERON_0005868`
#### Removed
-- [mature CD8 single-positive thymocyte](http://purl.obolibrary.org/obo/CL_0002437) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A mature CD8-positive, CD4-negative alpha-beta T cell found in the thymus that is CD24-low and has high expression of the T cell receptor."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:tfm"
-
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "http:www.immgen.org/index_content.html"
-
-#### Added
-- [mature CD8 single-positive thymocyte](http://purl.obolibrary.org/obo/CL_0002437) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A mature CD8-positive, CD4-negative alpha-beta T cell found in the thymus that is CD24-low and has high expression of the T cell receptor."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:tfm"
+- [maxillary prominence](http://purl.obolibrary.org/obo/UBERON_0005868) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "http://www.immgen.org/index_content.html"
-### medium spiny neuron `http://purl.obolibrary.org/obo/CL_1001474`
+### medial border of scapula `http://purl.obolibrary.org/obo/UBERON_0007174`
#### Removed
-- [medium spiny neuron](http://purl.obolibrary.org/obo/CL_1001474) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The inhibitory projection neurons located in the striatum that integrate glutamatergic signals arising from the cerebral cortex and thalamus."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "MP:0008462"
+- [medial border of scapula](http://purl.obolibrary.org/obo/UBERON_0007174) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [medium spiny neuron](http://purl.obolibrary.org/obo/CL_1001474) SubClassOf [neuron](http://purl.obolibrary.org/obo/CL_0000540)
-- [medium spiny neuron](http://purl.obolibrary.org/obo/CL_1001474) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [corpus striatum](http://purl.obolibrary.org/obo/UBERON_0000369)
-
-#### Added
-- [medium spiny neuron](http://purl.obolibrary.org/obo/CL_1001474) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "An inhibitory, GABAergic projection neuron in the striatum that integrates glutamatergic signals arising from the cerebral cortex and thalamus."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "MP:0008462"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1073/pnas.242428599"
+### medial ganglionic eminence derived GABAergic cortical interneuron `http://purl.obolibrary.org/obo/CL_4023069`
-- [medium spiny neuron](http://purl.obolibrary.org/obo/CL_1001474) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "gamma-aminobutyric acid (GABA)ergic spiny projection neuron"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1073/pnas.242428599"
+#### Added
+- [medial ganglionic eminence derived GABAergic cortical interneuron](http://purl.obolibrary.org/obo/CL_4023069) [symbol](http://purl.obolibrary.org/obo/IAO_0000028) "MGE cortical gaba interneuron"
-- [medium spiny neuron](http://purl.obolibrary.org/obo/CL_1001474) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "gamma-aminobutyric acid ergic spiny projection neuron"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1073/pnas.242428599"
-- [medium spiny neuron](http://purl.obolibrary.org/obo/CL_1001474) SubClassOf [central nervous system neuron](http://purl.obolibrary.org/obo/CL_2000029)
+### medial ganglionic eminence derived interneuron `http://purl.obolibrary.org/obo/CL_4023063`
+#### Removed
+- [medial ganglionic eminence derived interneuron](http://purl.obolibrary.org/obo/CL_4023063) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [medium spiny neuron](http://purl.obolibrary.org/obo/CL_1001474) SubClassOf [has soma location](http://purl.obolibrary.org/obo/RO_0002100) some [corpus striatum](http://purl.obolibrary.org/obo/UBERON_0000369)
+#### Added
+- [medial ganglionic eminence derived interneuron](http://purl.obolibrary.org/obo/CL_4023063) [symbol](http://purl.obolibrary.org/obo/IAO_0000028) "MGE interneuron"
-- [medium spiny neuron](http://purl.obolibrary.org/obo/CL_1001474) SubClassOf [GABAergic neuron](http://purl.obolibrary.org/obo/CL_0000617)
+### medial nasal prominence `http://purl.obolibrary.org/obo/UBERON_0004068`
+#### Removed
+- [medial nasal prominence](http://purl.obolibrary.org/obo/UBERON_0004068) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-### melanocyte `http://purl.obolibrary.org/obo/CL_0000148`
-#### Added
-- [melanocyte](http://purl.obolibrary.org/obo/CL_0000148) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [general_cell_types_upper_slim](http://purl.obolibrary.org/obo/cl#general_cell_types_upper_slim)
+### median lingual swelling `http://purl.obolibrary.org/obo/UBERON_0006756`
+#### Removed
+- [median lingual swelling](http://purl.obolibrary.org/obo/UBERON_0006756) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-### metallothionein-positive alveolar macrophage `http://purl.obolibrary.org/obo/CL_4033042`
-#### Added
-- [metallothionein-positive alveolar macrophage](http://purl.obolibrary.org/obo/CL_4033042) [date](http://purl.org/dc/terms/date) "2023-06-15T12:55:34Z"^^[dateTime](http://www.w3.org/2001/XMLSchema#dateTime)
-- [metallothionein-positive alveolar macrophage](http://purl.obolibrary.org/obo/CL_4033042) [contributor](http://purl.org/dc/terms/contributor) [0000-0001-6677-8489](https://orcid.org/0000-0001-6677-8489)
+### medium spiny neuron `http://purl.obolibrary.org/obo/CL_1001474`
+#### Removed
+- [medium spiny neuron](http://purl.obolibrary.org/obo/CL_1001474) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [metallothionein-positive alveolar macrophage](http://purl.obolibrary.org/obo/CL_4033042) [label](http://www.w3.org/2000/01/rdf-schema#label) "metallothionein-positive alveolar macrophage"
-- [metallothionein-positive alveolar macrophage](http://purl.obolibrary.org/obo/CL_4033042) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "alveolar macrophage MT-positive"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:37291214"
-- [metallothionein-positive alveolar macrophage](http://purl.obolibrary.org/obo/CL_4033042) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "alveolar macrophage metallothionein-positive"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:37291214"
+### medium-wave-sensitive opsin `http://purl.obolibrary.org/obo/PR_000001224`
-- [metallothionein-positive alveolar macrophage](http://purl.obolibrary.org/obo/CL_4033042) [contributor](http://purl.org/dc/terms/contributor) [0000-0002-9185-3994](https://orcid.org/0000-0002-9185-3994)
+#### Added
+- [medium-wave-sensitive opsin](http://purl.obolibrary.org/obo/PR_000001224) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [medium-wave-sensitive opsin (human)](http://purl.obolibrary.org/obo/PR_000050522)
-- [metallothionein-positive alveolar macrophage](http://purl.obolibrary.org/obo/CL_4033042) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "An alveolar macrophage that expresses metallothionein."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:37291214"
-- Class: [metallothionein-positive alveolar macrophage](http://purl.obolibrary.org/obo/CL_4033042)
+### medulla oblongata sulcus limitans `http://purl.obolibrary.org/obo/UBERON_0009576`
+#### Removed
+- [medulla oblongata sulcus limitans](http://purl.obolibrary.org/obo/UBERON_0009576) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [metallothionein-positive alveolar macrophage](http://purl.obolibrary.org/obo/CL_4033042) SubClassOf [alveolar macrophage](http://purl.obolibrary.org/obo/CL_0000583)
-### monocyte `http://purl.obolibrary.org/obo/CL_0000576`
+### medulla-projecting glutamatergic neuron of the primary motor cortex `http://purl.obolibrary.org/obo/CL_4023045`
#### Added
-- [monocyte](http://purl.obolibrary.org/obo/CL_0000576) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [general_cell_types_upper_slim](http://purl.obolibrary.org/obo/cl#general_cell_types_upper_slim)
+- [medulla-projecting glutamatergic neuron of the primary motor cortex](http://purl.obolibrary.org/obo/CL_4023045) [symbol](http://purl.obolibrary.org/obo/IAO_0000028) "MY ET glut MOp"
-### myelin assembly `http://purl.obolibrary.org/obo/GO_0032288`
+### meis2 expressing cortical GABAergic cell `http://purl.obolibrary.org/obo/CL_4023065`
#### Added
-- [myelin assembly](http://purl.obolibrary.org/obo/GO_0032288) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "myelin sheath assembly"
+- [meis2 expressing cortical GABAergic cell](http://purl.obolibrary.org/obo/CL_4023065) [symbol](http://purl.obolibrary.org/obo/IAO_0000028) "meis2 GABA"
-### myofibroblast cell `http://purl.obolibrary.org/obo/CL_0000186`
+### melanocyte `http://purl.obolibrary.org/obo/CL_0000148`
#### Removed
-- [myofibroblast cell](http://purl.obolibrary.org/obo/CL_0000186) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "An animal cell that has characteristics of both a fibroblast cell and a smooth muscle cell."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dsd"
-
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:tfm"
-
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:20630469"
+- [melanocyte](http://purl.obolibrary.org/obo/CL_0000148) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:19800625"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "MESH:D058628"
-- [myofibroblast cell](http://purl.obolibrary.org/obo/CL_0000186) SubClassOf [somatic cell](http://purl.obolibrary.org/obo/CL_0002371)
+### melanopsin `http://purl.obolibrary.org/obo/PR_000001243`
#### Added
-- [myofibroblast cell](http://purl.obolibrary.org/obo/CL_0000186) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "An animal cell that has characteristics of both a fibroblast cell and a smooth muscle cell."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dsd"
+- [melanopsin](http://purl.obolibrary.org/obo/PR_000001243) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [melanopsin (human)](http://purl.obolibrary.org/obo/PR_Q9UHM6)
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:tfm"
-
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:20630469"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:22387320"
+### meningeal cluster `http://purl.obolibrary.org/obo/UBERON_0010743`
+#### Removed
+- [meningeal cluster](http://purl.obolibrary.org/obo/UBERON_0010743) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:19800625"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "MESH:D058628"
-- [myofibroblast cell](http://purl.obolibrary.org/obo/CL_0000186) SubClassOf [connective tissue cell](http://purl.obolibrary.org/obo/CL_0002320)
+### mesangial cell `http://purl.obolibrary.org/obo/CL_0000650`
+#### Removed
+- [mesangial cell](http://purl.obolibrary.org/obo/CL_0000650) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-### natural killer cell `http://purl.obolibrary.org/obo/CL_0000623`
-#### Added
-- [natural killer cell](http://purl.obolibrary.org/obo/CL_0000623) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [general_cell_types_upper_slim](http://purl.obolibrary.org/obo/cl#general_cell_types_upper_slim)
+### mesangium `http://purl.obolibrary.org/obo/UBERON_0002319`
+#### Removed
+- [mesangium](http://purl.obolibrary.org/obo/UBERON_0002319) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-### negative regulation of ATP biosynthetic process `http://purl.obolibrary.org/obo/GO_2001170`
-#### Added
-- [negative regulation of ATP biosynthetic process](http://purl.obolibrary.org/obo/GO_2001170) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "negative regulation of ATP formation"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:obol"
+### mesenchyme derived from head neural crest `http://purl.obolibrary.org/obo/UBERON_0007213`
+#### Removed
+- [mesenchyme derived from head neural crest](http://purl.obolibrary.org/obo/UBERON_0007213) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [negative regulation of ATP biosynthetic process](http://purl.obolibrary.org/obo/GO_2001170) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "kmv"
-- [negative regulation of ATP biosynthetic process](http://purl.obolibrary.org/obo/GO_2001170) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2011-10-26T03:18:13Z"
-- [negative regulation of ATP biosynthetic process](http://purl.obolibrary.org/obo/GO_2001170) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "negative regulation of ATP biosynthesis"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:obol"
+### mesenchyme derived from trunk neural crest `http://purl.obolibrary.org/obo/UBERON_0007214`
+#### Removed
+- [mesenchyme derived from trunk neural crest](http://purl.obolibrary.org/obo/UBERON_0007214) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [negative regulation of ATP biosynthetic process](http://purl.obolibrary.org/obo/GO_2001170) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "negative regulation of ATP anabolism"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:obol"
-- [negative regulation of ATP biosynthetic process](http://purl.obolibrary.org/obo/GO_2001170) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "negative regulation of ATP regeneration"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:obol"
-- [negative regulation of ATP biosynthetic process](http://purl.obolibrary.org/obo/GO_2001170) [label](http://www.w3.org/2000/01/rdf-schema#label) "negative regulation of ATP biosynthetic process"
+### mesenchyme of lower jaw `http://purl.obolibrary.org/obo/UBERON_0003324`
+#### Removed
+- [mesenchyme of lower jaw](http://purl.obolibrary.org/obo/UBERON_0003324) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [negative regulation of ATP biosynthetic process](http://purl.obolibrary.org/obo/GO_2001170) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that stops, prevents or reduces the frequency, rate or extent of ATP biosynthetic process."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:obol"
-- [negative regulation of ATP biosynthetic process](http://purl.obolibrary.org/obo/GO_2001170) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "negative regulation of ATP synthesis"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:obol"
-- [negative regulation of ATP biosynthetic process](http://purl.obolibrary.org/obo/GO_2001170) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process"
+### mesenchyme of upper jaw `http://purl.obolibrary.org/obo/UBERON_0003323`
+#### Removed
+- [mesenchyme of upper jaw](http://purl.obolibrary.org/obo/UBERON_0003323) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [negative regulation of ATP biosynthetic process](http://purl.obolibrary.org/obo/GO_2001170) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:2001170"
-- Class: [negative regulation of ATP biosynthetic process](http://purl.obolibrary.org/obo/GO_2001170)
-- [negative regulation of ATP biosynthetic process](http://purl.obolibrary.org/obo/GO_2001170) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([negatively regulates](http://purl.obolibrary.org/obo/RO_0002212) some [ATP biosynthetic process](http://purl.obolibrary.org/obo/GO_0006754))
+### meso-epithelial cell `http://purl.obolibrary.org/obo/CL_0002078`
+#### Removed
+- [meso-epithelial cell](http://purl.obolibrary.org/obo/CL_0002078) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [negative regulation of ATP biosynthetic process](http://purl.obolibrary.org/obo/GO_2001170) SubClassOf [negative regulation of biosynthetic process](http://purl.obolibrary.org/obo/GO_0009890)
-- [negative regulation of ATP biosynthetic process](http://purl.obolibrary.org/obo/GO_2001170) SubClassOf [regulation of ATP biosynthetic process](http://purl.obolibrary.org/obo/GO_2001169)
-- [negative regulation of ATP biosynthetic process](http://purl.obolibrary.org/obo/GO_2001170) SubClassOf [negative regulation of ATP metabolic process](http://purl.obolibrary.org/obo/GO_1903579)
+### mesoderm-derived structure `http://purl.obolibrary.org/obo/UBERON_0004120`
+#### Removed
+- [mesoderm-derived structure](http://purl.obolibrary.org/obo/UBERON_0004120) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [negative regulation of ATP biosynthetic process](http://purl.obolibrary.org/obo/GO_2001170) SubClassOf [negatively regulates](http://purl.obolibrary.org/obo/RO_0002212) some [ATP biosynthetic process](http://purl.obolibrary.org/obo/GO_0006754)
-### negative regulation of ATP metabolic process `http://purl.obolibrary.org/obo/GO_1903579`
+### mesopodial skeleton `http://purl.obolibrary.org/obo/UBERON_0009878`
+#### Removed
+- [mesopodial skeleton](http://purl.obolibrary.org/obo/UBERON_0009878) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000)
-#### Added
-- [negative regulation of ATP metabolic process](http://purl.obolibrary.org/obo/GO_1903579) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:1903579"
-- [negative regulation of ATP metabolic process](http://purl.obolibrary.org/obo/GO_1903579) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "inhibition of ATP metabolism"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie"
-- [negative regulation of ATP metabolic process](http://purl.obolibrary.org/obo/GO_1903579) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "down regulation of ATP metabolic process"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie"
+### mesopodium region `http://purl.obolibrary.org/obo/UBERON_0006716`
+#### Removed
+- [mesopodium region](http://purl.obolibrary.org/obo/UBERON_0006716) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000)
-- [negative regulation of ATP metabolic process](http://purl.obolibrary.org/obo/GO_1903579) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "sl"
-- [negative regulation of ATP metabolic process](http://purl.obolibrary.org/obo/GO_1903579) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "down regulation of ATP metabolism"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie"
-- [negative regulation of ATP metabolic process](http://purl.obolibrary.org/obo/GO_1903579) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2014-10-30T19:04:33Z"
+### metadata complete `http://purl.obolibrary.org/obo/IAO_0000120`
-- [negative regulation of ATP metabolic process](http://purl.obolibrary.org/obo/GO_1903579) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "downregulation of ATP metabolic process"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie"
+#### Added
+- [metadata complete](http://purl.obolibrary.org/obo/IAO_0000120) [label](http://www.w3.org/2000/01/rdf-schema#label) "metadata complete"@en
-- [negative regulation of ATP metabolic process](http://purl.obolibrary.org/obo/GO_1903579) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process"
+- [metadata complete](http://purl.obolibrary.org/obo/IAO_0000120) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "metadata complete"@en
-- [negative regulation of ATP metabolic process](http://purl.obolibrary.org/obo/GO_1903579) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that stops, prevents or reduces the frequency, rate or extent of ATP metabolic process."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:20695849"
+- [metadata complete](http://purl.obolibrary.org/obo/IAO_0000120) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Class has all its metadata, but is either not guaranteed to be in its final location in the asserted IS_A hierarchy or refers to another class that is not complete."@en
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie"
+- Individual: [metadata complete](http://purl.obolibrary.org/obo/IAO_0000120)
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GO_REF:0000058"
-- [negative regulation of ATP metabolic process](http://purl.obolibrary.org/obo/GO_1903579) [label](http://www.w3.org/2000/01/rdf-schema#label) "negative regulation of ATP metabolic process"
+### metadata incomplete `http://purl.obolibrary.org/obo/IAO_0000123`
-- [negative regulation of ATP metabolic process](http://purl.obolibrary.org/obo/GO_1903579) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "inhibition of ATP metabolic process"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie"
+#### Added
+- [metadata incomplete](http://purl.obolibrary.org/obo/IAO_0000123) [label](http://www.w3.org/2000/01/rdf-schema#label) "metadata incomplete"@en
-- [negative regulation of ATP metabolic process](http://purl.obolibrary.org/obo/GO_1903579) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "negative regulation of ATP metabolism"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie"
+- [metadata incomplete](http://purl.obolibrary.org/obo/IAO_0000123) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "metadata incomplete"@en
-- [negative regulation of ATP metabolic process](http://purl.obolibrary.org/obo/GO_1903579) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "down-regulation of ATP metabolic process"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie"
+- [metadata incomplete](http://purl.obolibrary.org/obo/IAO_0000123) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Class is being worked on; however, the metadata (including definition) are not complete or sufficiently clear to the branch editors."@en
-- [negative regulation of ATP metabolic process](http://purl.obolibrary.org/obo/GO_1903579) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "down-regulation of ATP metabolism"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie"
+- Individual: [metadata incomplete](http://purl.obolibrary.org/obo/IAO_0000123)
-- [negative regulation of ATP metabolic process](http://purl.obolibrary.org/obo/GO_1903579) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "downregulation of ATP metabolism"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie"
-- Class: [negative regulation of ATP metabolic process](http://purl.obolibrary.org/obo/GO_1903579)
+### metanephric mesenchyme `http://purl.obolibrary.org/obo/UBERON_0003220`
+#### Removed
+- [metanephric mesenchyme](http://purl.obolibrary.org/obo/UBERON_0003220) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-- [negative regulation of ATP metabolic process](http://purl.obolibrary.org/obo/GO_1903579) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([negatively regulates](http://purl.obolibrary.org/obo/RO_0002212) some [ATP metabolic process](http://purl.obolibrary.org/obo/GO_0046034))
-- [negative regulation of ATP metabolic process](http://purl.obolibrary.org/obo/GO_1903579) SubClassOf [negatively regulates](http://purl.obolibrary.org/obo/RO_0002212) some [ATP metabolic process](http://purl.obolibrary.org/obo/GO_0046034)
-- [negative regulation of ATP metabolic process](http://purl.obolibrary.org/obo/GO_1903579) SubClassOf [regulation of ATP metabolic process](http://purl.obolibrary.org/obo/GO_1903578)
+### metanephric mesenchyme stem cell `http://purl.obolibrary.org/obo/CL_0000324`
+#### Removed
+- [metanephric mesenchyme stem cell](http://purl.obolibrary.org/obo/CL_0000324) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [negative regulation of ATP metabolic process](http://purl.obolibrary.org/obo/GO_1903579) SubClassOf [negative regulation of metabolic process](http://purl.obolibrary.org/obo/GO_0009892)
-### negative regulation of ATP-dependent activity `http://purl.obolibrary.org/obo/GO_0032780`
+### metanephros induced blastemal cells `http://purl.obolibrary.org/obo/UBERON_0010531`
#### Removed
-- [negative regulation of ATP-dependent activity](http://purl.obolibrary.org/obo/GO_0032780) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [term_scheduled_for_obsoletion](http://purl.obolibrary.org/obo/go#term_scheduled_for_obsoletion)
+- [metanephros induced blastemal cells](http://purl.obolibrary.org/obo/UBERON_0010531) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-#### Added
-- [negative regulation of ATP-dependent activity](http://purl.obolibrary.org/obo/GO_0032780) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate)
-### negative regulation of DNA binding `http://purl.obolibrary.org/obo/GO_0043392`
+### metapodial skeleton `http://purl.obolibrary.org/obo/UBERON_0010546`
#### Removed
-- [negative regulation of DNA binding](http://purl.obolibrary.org/obo/GO_0043392) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [term_scheduled_for_obsoletion](http://purl.obolibrary.org/obo/go#term_scheduled_for_obsoletion)
+- [metapodial skeleton](http://purl.obolibrary.org/obo/UBERON_0010546) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000)
-#### Added
-- [negative regulation of DNA binding](http://purl.obolibrary.org/obo/GO_0043392) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate)
-### negative regulation of RNA binding `http://purl.obolibrary.org/obo/GO_1905215`
+### metapodium region `http://purl.obolibrary.org/obo/UBERON_0009877`
#### Removed
-- [negative regulation of RNA binding](http://purl.obolibrary.org/obo/GO_1905215) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [term_scheduled_for_obsoletion](http://purl.obolibrary.org/obo/go#term_scheduled_for_obsoletion)
+- [metapodium region](http://purl.obolibrary.org/obo/UBERON_0009877) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000)
-#### Added
-- [negative regulation of RNA binding](http://purl.obolibrary.org/obo/GO_1905215) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate)
-### negative regulation of acetylcholine-gated cation channel activity `http://purl.obolibrary.org/obo/GO_1903049`
-#### Removed
-- [negative regulation of acetylcholine-gated cation channel activity](http://purl.obolibrary.org/obo/GO_1903049) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [term_scheduled_for_obsoletion](http://purl.obolibrary.org/obo/go#term_scheduled_for_obsoletion)
+### metastasis-suppressor KiSS-1 `http://purl.obolibrary.org/obo/PR_000009344`
#### Added
-- [negative regulation of acetylcholine-gated cation channel activity](http://purl.obolibrary.org/obo/GO_1903049) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate)
+- [metastasis-suppressor KiSS-1](http://purl.obolibrary.org/obo/PR_000009344) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [metastasis-suppressor KiSS-1 (human)](http://purl.obolibrary.org/obo/PR_Q15726)
-### negative regulation of binding `http://purl.obolibrary.org/obo/GO_0051100`
+### microglial cell `http://purl.obolibrary.org/obo/CL_0000129`
#### Removed
-- [negative regulation of binding](http://purl.obolibrary.org/obo/GO_0051100) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [term_scheduled_for_obsoletion](http://purl.obolibrary.org/obo/go#term_scheduled_for_obsoletion)
+- [microglial cell](http://purl.obolibrary.org/obo/CL_0000129) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "microglia"
+
+- [microglial cell](http://purl.obolibrary.org/obo/CL_0000129) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
#### Added
-- [negative regulation of binding](http://purl.obolibrary.org/obo/GO_0051100) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate)
+- [microglial cell](http://purl.obolibrary.org/obo/CL_0000129) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "microglia"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [plural term](http://purl.obolibrary.org/obo/uberon#PLURAL)
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1038/s41598-020-66092-9"
-### negative regulation of calcium ion binding `http://purl.obolibrary.org/obo/GO_1901877`
+
+### midbrain dopaminergic neuron `http://purl.obolibrary.org/obo/CL_2000097`
#### Removed
-- [negative regulation of calcium ion binding](http://purl.obolibrary.org/obo/GO_1901877) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [term_scheduled_for_obsoletion](http://purl.obolibrary.org/obo/go#term_scheduled_for_obsoletion)
+- [midbrain dopaminergic neuron](http://purl.obolibrary.org/obo/CL_2000097) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-#### Added
-- [negative regulation of calcium ion binding](http://purl.obolibrary.org/obo/GO_1901877) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate)
-### negative regulation of calcium ion transmembrane transporter activity `http://purl.obolibrary.org/obo/GO_1901020`
+### molecular layer of cerebellar cortex `http://purl.obolibrary.org/obo/UBERON_0002974`
#### Removed
-- [negative regulation of calcium ion transmembrane transporter activity](http://purl.obolibrary.org/obo/GO_1901020) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [term_scheduled_for_obsoletion](http://purl.obolibrary.org/obo/go#term_scheduled_for_obsoletion)
+- [molecular layer of cerebellar cortex](http://purl.obolibrary.org/obo/UBERON_0002974) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-#### Added
-- [negative regulation of calcium ion transmembrane transporter activity](http://purl.obolibrary.org/obo/GO_1901020) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate)
-### negative regulation of catalytic activity `http://purl.obolibrary.org/obo/GO_0043086`
+### monoblast `http://purl.obolibrary.org/obo/CL_0000040`
#### Removed
-- [negative regulation of catalytic activity](http://purl.obolibrary.org/obo/GO_0043086) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [term_scheduled_for_obsoletion](http://purl.obolibrary.org/obo/go#term_scheduled_for_obsoletion)
+- [monoblast](http://purl.obolibrary.org/obo/CL_0000040) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-#### Added
-- [negative regulation of catalytic activity](http://purl.obolibrary.org/obo/GO_0043086) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate)
-### negative regulation of cation channel activity `http://purl.obolibrary.org/obo/GO_2001258`
+### mouth `http://purl.obolibrary.org/obo/UBERON_0000165`
#### Removed
-- [negative regulation of cation channel activity](http://purl.obolibrary.org/obo/GO_2001258) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [term_scheduled_for_obsoletion](http://purl.obolibrary.org/obo/go#term_scheduled_for_obsoletion)
+- [mouth](http://purl.obolibrary.org/obo/UBERON_0000165) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-#### Added
-- [negative regulation of cation channel activity](http://purl.obolibrary.org/obo/GO_2001258) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate)
-### negative regulation of chromatin binding `http://purl.obolibrary.org/obo/GO_0035562`
+### multi-limb segment region `http://purl.obolibrary.org/obo/UBERON_0006058`
#### Removed
-- [negative regulation of chromatin binding](http://purl.obolibrary.org/obo/GO_0035562) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [term_scheduled_for_obsoletion](http://purl.obolibrary.org/obo/go#term_scheduled_for_obsoletion)
+- [multi-limb segment region](http://purl.obolibrary.org/obo/UBERON_0006058) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-#### Added
-- [negative regulation of chromatin binding](http://purl.obolibrary.org/obo/GO_0035562) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate)
-### negative regulation of collagen binding `http://purl.obolibrary.org/obo/GO_0033342`
+### muscle cell `http://purl.obolibrary.org/obo/CL_0000187`
#### Removed
-- [negative regulation of collagen binding](http://purl.obolibrary.org/obo/GO_0033342) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [term_scheduled_for_obsoletion](http://purl.obolibrary.org/obo/go#term_scheduled_for_obsoletion)
+- [muscle cell](http://purl.obolibrary.org/obo/CL_0000187) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-#### Added
-- [negative regulation of collagen binding](http://purl.obolibrary.org/obo/GO_0033342) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate)
-### negative regulation of deoxyribonuclease activity `http://purl.obolibrary.org/obo/GO_0032076`
+### muscle precursor cell `http://purl.obolibrary.org/obo/CL_0000680`
#### Removed
-- [negative regulation of deoxyribonuclease activity](http://purl.obolibrary.org/obo/GO_0032076) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [term_scheduled_for_obsoletion](http://purl.obolibrary.org/obo/go#term_scheduled_for_obsoletion)
+- [muscle precursor cell](http://purl.obolibrary.org/obo/CL_0000680) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-#### Added
-- [negative regulation of deoxyribonuclease activity](http://purl.obolibrary.org/obo/GO_0032076) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate)
-### negative regulation of euchromatin binding `http://purl.obolibrary.org/obo/GO_1904794`
+### muscle structure `http://purl.obolibrary.org/obo/UBERON_0005090`
#### Removed
-- [negative regulation of euchromatin binding](http://purl.obolibrary.org/obo/GO_1904794) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [term_scheduled_for_obsoletion](http://purl.obolibrary.org/obo/go#term_scheduled_for_obsoletion)
+- [muscle structure](http://purl.obolibrary.org/obo/UBERON_0005090) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-#### Added
-- [negative regulation of euchromatin binding](http://purl.obolibrary.org/obo/GO_1904794) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate)
-### negative regulation of hydrolase activity `http://purl.obolibrary.org/obo/GO_0051346`
+### musculature `http://purl.obolibrary.org/obo/UBERON_0001015`
#### Removed
-- [negative regulation of hydrolase activity](http://purl.obolibrary.org/obo/GO_0051346) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [term_scheduled_for_obsoletion](http://purl.obolibrary.org/obo/go#term_scheduled_for_obsoletion)
+- [musculature](http://purl.obolibrary.org/obo/UBERON_0001015) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-#### Added
-- [negative regulation of hydrolase activity](http://purl.obolibrary.org/obo/GO_0051346) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate)
-### negative regulation of ion transmembrane transporter activity `http://purl.obolibrary.org/obo/GO_0032413`
+### musculature of body `http://purl.obolibrary.org/obo/UBERON_0000383`
#### Removed
-- [negative regulation of ion transmembrane transporter activity](http://purl.obolibrary.org/obo/GO_0032413) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [term_scheduled_for_obsoletion](http://purl.obolibrary.org/obo/go#term_scheduled_for_obsoletion)
+- [musculature of body](http://purl.obolibrary.org/obo/UBERON_0000383) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-#### Added
-- [negative regulation of ion transmembrane transporter activity](http://purl.obolibrary.org/obo/GO_0032413) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate)
-### negative regulation of iron ion transmembrane transporter activity `http://purl.obolibrary.org/obo/GO_1904255`
+### musculature of hip `http://purl.obolibrary.org/obo/UBERON_0004475`
#### Removed
-- [negative regulation of iron ion transmembrane transporter activity](http://purl.obolibrary.org/obo/GO_1904255) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [term_scheduled_for_obsoletion](http://purl.obolibrary.org/obo/go#term_scheduled_for_obsoletion)
+- [musculature of hip](http://purl.obolibrary.org/obo/UBERON_0004475) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000)
-#### Added
-- [negative regulation of iron ion transmembrane transporter activity](http://purl.obolibrary.org/obo/GO_1904255) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate)
-### negative regulation of kinase activity `http://purl.obolibrary.org/obo/GO_0033673`
+### musculature of shoulder `http://purl.obolibrary.org/obo/UBERON_0004476`
#### Removed
-- [negative regulation of kinase activity](http://purl.obolibrary.org/obo/GO_0033673) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [term_scheduled_for_obsoletion](http://purl.obolibrary.org/obo/go#term_scheduled_for_obsoletion)
+- [musculature of shoulder](http://purl.obolibrary.org/obo/UBERON_0004476) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000)
-#### Added
-- [negative regulation of kinase activity](http://purl.obolibrary.org/obo/GO_0033673) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate)
-### negative regulation of ligase activity `http://purl.obolibrary.org/obo/GO_0051352`
+### musculoskeletal system `http://purl.obolibrary.org/obo/UBERON_0002204`
#### Removed
-- [negative regulation of ligase activity](http://purl.obolibrary.org/obo/GO_0051352) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [term_scheduled_for_obsoletion](http://purl.obolibrary.org/obo/go#term_scheduled_for_obsoletion)
+- [musculoskeletal system](http://purl.obolibrary.org/obo/UBERON_0002204) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-#### Added
-- [negative regulation of ligase activity](http://purl.obolibrary.org/obo/GO_0051352) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate)
-### negative regulation of lipid binding `http://purl.obolibrary.org/obo/GO_1900131`
+### myeloid cell `http://purl.obolibrary.org/obo/CL_0000763`
#### Removed
-- [negative regulation of lipid binding](http://purl.obolibrary.org/obo/GO_1900131) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [term_scheduled_for_obsoletion](http://purl.obolibrary.org/obo/go#term_scheduled_for_obsoletion)
+- [myeloid cell](http://purl.obolibrary.org/obo/CL_0000763) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-#### Added
-- [negative regulation of lipid binding](http://purl.obolibrary.org/obo/GO_1900131) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate)
-### negative regulation of lipid transporter activity `http://purl.obolibrary.org/obo/GO_0110114`
+### myeloid suppressor cell `http://purl.obolibrary.org/obo/CL_0000889`
#### Removed
-- [negative regulation of lipid transporter activity](http://purl.obolibrary.org/obo/GO_0110114) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [term_scheduled_for_obsoletion](http://purl.obolibrary.org/obo/go#term_scheduled_for_obsoletion)
+- [myeloid suppressor cell](http://purl.obolibrary.org/obo/CL_0000889) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-#### Added
-- [negative regulation of lipid transporter activity](http://purl.obolibrary.org/obo/GO_0110114) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate)
-### negative regulation of microtubule binding `http://purl.obolibrary.org/obo/GO_1904527`
-#### Removed
-- [negative regulation of microtubule binding](http://purl.obolibrary.org/obo/GO_1904527) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [term_scheduled_for_obsoletion](http://purl.obolibrary.org/obo/go#term_scheduled_for_obsoletion)
+### myeloperoxidase `http://purl.obolibrary.org/obo/PR_000010543`
#### Added
-- [negative regulation of microtubule binding](http://purl.obolibrary.org/obo/GO_1904527) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate)
+- [myeloperoxidase](http://purl.obolibrary.org/obo/PR_000010543) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [myeloperoxidase (human)](http://purl.obolibrary.org/obo/PR_P05164)
-### negative regulation of molecular function `http://purl.obolibrary.org/obo/GO_0044092`
+### myoepithelium `http://purl.obolibrary.org/obo/UBERON_0000420`
#### Removed
-- [negative regulation of molecular function](http://purl.obolibrary.org/obo/GO_0044092) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [term_scheduled_for_obsoletion](http://purl.obolibrary.org/obo/go#term_scheduled_for_obsoletion)
+- [myoepithelium](http://purl.obolibrary.org/obo/UBERON_0000420) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-#### Added
-- [negative regulation of molecular function](http://purl.obolibrary.org/obo/GO_0044092) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate)
-### negative regulation of nuclease activity `http://purl.obolibrary.org/obo/GO_0032074`
+### myotome `http://purl.obolibrary.org/obo/UBERON_0003082`
#### Removed
-- [negative regulation of nuclease activity](http://purl.obolibrary.org/obo/GO_0032074) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [term_scheduled_for_obsoletion](http://purl.obolibrary.org/obo/go#term_scheduled_for_obsoletion)
+- [myotome](http://purl.obolibrary.org/obo/UBERON_0003082) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-#### Added
-- [negative regulation of nuclease activity](http://purl.obolibrary.org/obo/GO_0032074) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate)
-### negative regulation of peptidase activity `http://purl.obolibrary.org/obo/GO_0010466`
-#### Removed
-- [negative regulation of peptidase activity](http://purl.obolibrary.org/obo/GO_0010466) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process"
+### named class expression `http://purl.obolibrary.org/obo/IAO_0000421`
-- [negative regulation of peptidase activity](http://purl.obolibrary.org/obo/GO_0010466) [label](http://www.w3.org/2000/01/rdf-schema#label) "negative regulation of peptidase activity"
+#### Added
+- [named class expression](http://purl.obolibrary.org/obo/IAO_0000421) [editor note](http://purl.obolibrary.org/obo/IAO_0000116) "named class expressions are used in order to have more concise logical definition but their extensions may not be interesting classes on their own. In languages such as OWL, with no provisions for macros, these show up as actuall classes. Tools may with to not show them as such, and to replace uses of the macros with their expansions"@en
-- [negative regulation of peptidase activity](http://purl.obolibrary.org/obo/GO_0010466) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0010466"
+- [named class expression](http://purl.obolibrary.org/obo/IAO_0000421) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "named class expression"@en
-- [negative regulation of peptidase activity](http://purl.obolibrary.org/obo/GO_0010466) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that stops or reduces the rate of peptidase activity, the hydrolysis of peptide bonds within proteins."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dph"
+- [named class expression](http://purl.obolibrary.org/obo/IAO_0000421) [IAO_0000117](http://purl.obolibrary.org/obo/IAO_0000117) "Alan Ruttenberg"@en
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:tb"
+- [named class expression](http://purl.obolibrary.org/obo/IAO_0000421) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A named class expression is a logical expression that is given a name. The name can be used in place of the expression."@en
-- [negative regulation of peptidase activity](http://purl.obolibrary.org/obo/GO_0010466) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [term_scheduled_for_obsoletion](http://purl.obolibrary.org/obo/go#term_scheduled_for_obsoletion)
+- [named class expression](http://purl.obolibrary.org/obo/IAO_0000421) [label](http://www.w3.org/2000/01/rdf-schema#label) "named class expression"@en
-- Class: [negative regulation of peptidase activity](http://purl.obolibrary.org/obo/GO_0010466)
+- Individual: [named class expression](http://purl.obolibrary.org/obo/IAO_0000421)
-- [negative regulation of peptidase activity](http://purl.obolibrary.org/obo/GO_0010466) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([negatively regulates](http://purl.obolibrary.org/obo/RO_0002212) some [peptidase activity](http://purl.obolibrary.org/obo/GO_0008233))
-- [negative regulation of peptidase activity](http://purl.obolibrary.org/obo/GO_0010466) SubClassOf [negative regulation of proteolysis](http://purl.obolibrary.org/obo/GO_0045861)
+### nasal cavity `http://purl.obolibrary.org/obo/UBERON_0001707`
+#### Removed
+- [nasal cavity](http://purl.obolibrary.org/obo/UBERON_0001707) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [negative regulation of peptidase activity](http://purl.obolibrary.org/obo/GO_0010466) SubClassOf [negative regulation of hydrolase activity](http://purl.obolibrary.org/obo/GO_0051346)
-- [negative regulation of peptidase activity](http://purl.obolibrary.org/obo/GO_0010466) SubClassOf [negatively regulates](http://purl.obolibrary.org/obo/RO_0002212) some [peptidase activity](http://purl.obolibrary.org/obo/GO_0008233)
-- [negative regulation of peptidase activity](http://purl.obolibrary.org/obo/GO_0010466) SubClassOf [regulation of peptidase activity](http://purl.obolibrary.org/obo/GO_0052547)
+### nasal skeleton `http://purl.obolibrary.org/obo/UBERON_0006813`
+#### Removed
+- [nasal skeleton](http://purl.obolibrary.org/obo/UBERON_0006813) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000)
-### negative regulation of protein binding `http://purl.obolibrary.org/obo/GO_0032091`
+### nasolacrimal duct `http://purl.obolibrary.org/obo/UBERON_0002392`
#### Removed
-- [negative regulation of protein binding](http://purl.obolibrary.org/obo/GO_0032091) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [term_scheduled_for_obsoletion](http://purl.obolibrary.org/obo/go#term_scheduled_for_obsoletion)
+- [nasolacrimal duct](http://purl.obolibrary.org/obo/UBERON_0002392) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-#### Added
-- [negative regulation of protein binding](http://purl.obolibrary.org/obo/GO_0032091) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate)
-### negative regulation of protein kinase activity `http://purl.obolibrary.org/obo/GO_0006469`
+### nasolacrimal groove `http://purl.obolibrary.org/obo/UBERON_0006266`
#### Removed
-- [negative regulation of protein kinase activity](http://purl.obolibrary.org/obo/GO_0006469) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [term_scheduled_for_obsoletion](http://purl.obolibrary.org/obo/go#term_scheduled_for_obsoletion)
+- [nasolacrimal groove](http://purl.obolibrary.org/obo/UBERON_0006266) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-#### Added
-- [negative regulation of protein kinase activity](http://purl.obolibrary.org/obo/GO_0006469) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate)
-### negative regulation of protein serine/threonine kinase activity `http://purl.obolibrary.org/obo/GO_0071901`
-#### Removed
-- [negative regulation of protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0071901) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [term_scheduled_for_obsoletion](http://purl.obolibrary.org/obo/go#term_scheduled_for_obsoletion)
+### natural cytotoxicity triggering receptor 1 `http://purl.obolibrary.org/obo/PR_000001893`
#### Added
-- [negative regulation of protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0071901) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate)
+- [natural cytotoxicity triggering receptor 1](http://purl.obolibrary.org/obo/PR_000001893) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [natural cytotoxicity triggering receptor 1 (human)](http://purl.obolibrary.org/obo/PR_O76036)
-### negative regulation of protein tyrosine kinase activity `http://purl.obolibrary.org/obo/GO_0061099`
-#### Removed
-- [negative regulation of protein tyrosine kinase activity](http://purl.obolibrary.org/obo/GO_0061099) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [term_scheduled_for_obsoletion](http://purl.obolibrary.org/obo/go#term_scheduled_for_obsoletion)
+### natural cytotoxicity triggering receptor 2 `http://purl.obolibrary.org/obo/PR_000001894`
#### Added
-- [negative regulation of protein tyrosine kinase activity](http://purl.obolibrary.org/obo/GO_0061099) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate)
+- [natural cytotoxicity triggering receptor 2](http://purl.obolibrary.org/obo/PR_000001894) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [natural cytotoxicity triggering receptor 2 (human)](http://purl.obolibrary.org/obo/PR_O95944)
-### negative regulation of receptor binding `http://purl.obolibrary.org/obo/GO_1900121`
+### natural helper lymphocyte `http://purl.obolibrary.org/obo/CL_0002679`
#### Removed
-- [negative regulation of receptor binding](http://purl.obolibrary.org/obo/GO_1900121) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [term_scheduled_for_obsoletion](http://purl.obolibrary.org/obo/go#term_scheduled_for_obsoletion)
+- [natural helper lymphocyte](http://purl.obolibrary.org/obo/CL_0002679) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-#### Added
-- [negative regulation of receptor binding](http://purl.obolibrary.org/obo/GO_1900121) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate)
-### negative regulation of signaling receptor activity `http://purl.obolibrary.org/obo/GO_2000272`
-#### Removed
-- [negative regulation of signaling receptor activity](http://purl.obolibrary.org/obo/GO_2000272) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [term_scheduled_for_obsoletion](http://purl.obolibrary.org/obo/go#term_scheduled_for_obsoletion)
+### natural killer cell receptor 2B4 `http://purl.obolibrary.org/obo/PR_000001896`
#### Added
-- [negative regulation of signaling receptor activity](http://purl.obolibrary.org/obo/GO_2000272) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate)
+- [natural killer cell receptor 2B4](http://purl.obolibrary.org/obo/PR_000001896) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [natural killer cell receptor 2B4 (human)](http://purl.obolibrary.org/obo/PR_Q9BZW8)
-### negative regulation of transferase activity `http://purl.obolibrary.org/obo/GO_0051348`
-#### Removed
-- [negative regulation of transferase activity](http://purl.obolibrary.org/obo/GO_0051348) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [term_scheduled_for_obsoletion](http://purl.obolibrary.org/obo/go#term_scheduled_for_obsoletion)
+### near-projecting glutamatergic cortical neuron `http://purl.obolibrary.org/obo/CL_4023012`
#### Added
-- [negative regulation of transferase activity](http://purl.obolibrary.org/obo/GO_0051348) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate)
+- [near-projecting glutamatergic cortical neuron](http://purl.obolibrary.org/obo/CL_4023012) [symbol](http://purl.obolibrary.org/obo/IAO_0000028) "NP glut neuron"
-### negative regulation of transporter activity `http://purl.obolibrary.org/obo/GO_0032410`
+### nephrogenic cord `http://purl.obolibrary.org/obo/UBERON_0004875`
#### Removed
-- [negative regulation of transporter activity](http://purl.obolibrary.org/obo/GO_0032410) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [term_scheduled_for_obsoletion](http://purl.obolibrary.org/obo/go#term_scheduled_for_obsoletion)
+- [nephrogenic cord](http://purl.obolibrary.org/obo/UBERON_0004875) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-#### Added
-- [negative regulation of transporter activity](http://purl.obolibrary.org/obo/GO_0032410) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate)
-### negative regulation of water channel activity `http://purl.obolibrary.org/obo/GO_1902428`
+### nephrogenic mesenchyme `http://purl.obolibrary.org/obo/UBERON_0004208`
#### Removed
-- [negative regulation of water channel activity](http://purl.obolibrary.org/obo/GO_1902428) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [term_scheduled_for_obsoletion](http://purl.obolibrary.org/obo/go#term_scheduled_for_obsoletion)
+- [nephrogenic mesenchyme](http://purl.obolibrary.org/obo/UBERON_0004208) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-#### Added
-- [negative regulation of water channel activity](http://purl.obolibrary.org/obo/GO_1902428) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate)
-### neurectoderm `http://purl.obolibrary.org/obo/UBERON_0002346`
+### nephron `http://purl.obolibrary.org/obo/UBERON_0001285`
#### Removed
-- [neurectoderm](http://purl.obolibrary.org/obo/UBERON_0002346) SubClassOf [has part](http://purl.obolibrary.org/obo/BFO_0000051) some [primary neuron](http://purl.obolibrary.org/obo/CL_0000530)
- - [source](http://www.geneontology.org/formats/oboInOwl#source) "ZFA"
+- [nephron](http://purl.obolibrary.org/obo/UBERON_0001285) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-### neuroblast activation `http://purl.obolibrary.org/obo/GO_0007407`
+### nephron progenitor `http://purl.obolibrary.org/obo/UBERON_0010536`
#### Removed
-- [neuroblast activation](http://purl.obolibrary.org/obo/GO_0007407) SubClassOf [only in taxon](http://purl.obolibrary.org/obo/RO_0002160) some [Metazoa](http://purl.obolibrary.org/obo/NCBITaxon_33208)
+- [nephron progenitor](http://purl.obolibrary.org/obo/UBERON_0010536) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-### neuron `http://purl.obolibrary.org/obo/CL_0000540`
+### nephron tubule `http://purl.obolibrary.org/obo/UBERON_0001231`
+#### Removed
+- [nephron tubule](http://purl.obolibrary.org/obo/UBERON_0001231) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-#### Added
-- [neuron](http://purl.obolibrary.org/obo/CL_0000540) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [general_cell_types_upper_slim](http://purl.obolibrary.org/obo/cl#general_cell_types_upper_slim)
-### neurotransmitter transmembrane transporter activity `http://purl.obolibrary.org/obo/GO_0005326`
+### neprilysin `http://purl.obolibrary.org/obo/PR_000001898`
#### Added
-- [neurotransmitter transmembrane transporter activity](http://purl.obolibrary.org/obo/GO_0005326) SubClassOf [in taxon](http://purl.obolibrary.org/obo/RO_0002162) only [Eumetazoa](http://purl.obolibrary.org/obo/NCBITaxon_6072)
+- [neprilysin](http://purl.obolibrary.org/obo/PR_000001898) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [neprilysin (human)](http://purl.obolibrary.org/obo/PR_P08473)
-- [neurotransmitter transmembrane transporter activity](http://purl.obolibrary.org/obo/GO_0005326) SubClassOf [only in taxon](http://purl.obolibrary.org/obo/RO_0002160) some [Eumetazoa](http://purl.obolibrary.org/obo/NCBITaxon_6072)
-
-### nucleophagy `http://purl.obolibrary.org/obo/GO_0044804`
+### nerve innervating pinna `http://purl.obolibrary.org/obo/UBERON_0035648`
#### Removed
-- [nucleophagy](http://purl.obolibrary.org/obo/GO_0044804) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "nucleophagy"
+- [nerve innervating pinna](http://purl.obolibrary.org/obo/UBERON_0035648) SubClassOf [neuron projection bundle](http://purl.obolibrary.org/obo/CARO_0001001)
-- [nucleophagy](http://purl.obolibrary.org/obo/GO_0044804) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "nucleus degradation"
-- [nucleophagy](http://purl.obolibrary.org/obo/GO_0044804) [label](http://www.w3.org/2000/01/rdf-schema#label) "autophagy of nucleus"
-#### Added
-- [nucleophagy](http://purl.obolibrary.org/obo/GO_0044804) [label](http://www.w3.org/2000/01/rdf-schema#label) "nucleophagy"
+### nerve of clitoris `http://purl.obolibrary.org/obo/UBERON_0035650`
+#### Removed
+- [nerve of clitoris](http://purl.obolibrary.org/obo/UBERON_0035650) SubClassOf [neuron projection bundle](http://purl.obolibrary.org/obo/CARO_0001001)
-- [nucleophagy](http://purl.obolibrary.org/obo/GO_0044804) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "nucleus degradation"
-- [nucleophagy](http://purl.obolibrary.org/obo/GO_0044804) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "autophagy of nucleus"
+### nerve of penis `http://purl.obolibrary.org/obo/UBERON_0035649`
+#### Removed
+- [nerve of penis](http://purl.obolibrary.org/obo/UBERON_0035649) SubClassOf [neuron projection bundle](http://purl.obolibrary.org/obo/CARO_0001001)
-### nucleoside diphosphate biosynthetic process `http://purl.obolibrary.org/obo/GO_0009133`
-#### Added
-- [nucleoside diphosphate biosynthetic process](http://purl.obolibrary.org/obo/GO_0009133) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process"
-- [nucleoside diphosphate biosynthetic process](http://purl.obolibrary.org/obo/GO_0009133) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "nucleoside diphosphate synthesis"
+### nervous system `http://purl.obolibrary.org/obo/UBERON_0001016`
+#### Removed
+- [nervous system](http://purl.obolibrary.org/obo/UBERON_0001016) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-- [nucleoside diphosphate biosynthetic process](http://purl.obolibrary.org/obo/GO_0009133) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "nucleoside diphosphate anabolism"
-- [nucleoside diphosphate biosynthetic process](http://purl.obolibrary.org/obo/GO_0009133) [label](http://www.w3.org/2000/01/rdf-schema#label) "nucleoside diphosphate biosynthetic process"
-- [nucleoside diphosphate biosynthetic process](http://purl.obolibrary.org/obo/GO_0009133) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "nucleoside diphosphate biosynthesis"
+### netrin-G1 `http://purl.obolibrary.org/obo/PR_000011467`
-- [nucleoside diphosphate biosynthetic process](http://purl.obolibrary.org/obo/GO_0009133) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0009133"
+#### Added
+- [netrin-G1](http://purl.obolibrary.org/obo/PR_000011467) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [netrin-G1 (human)](http://purl.obolibrary.org/obo/PR_Q9Y2I2)
-- [nucleoside diphosphate biosynthetic process](http://purl.obolibrary.org/obo/GO_0009133) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "nucleoside diphosphate formation"
-- [nucleoside diphosphate biosynthetic process](http://purl.obolibrary.org/obo/GO_0009133) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The chemical reactions and pathways resulting in the formation of a nucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with diphosphate on the sugar."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:go_curators"
+### neural cell adhesion molecule 1 `http://purl.obolibrary.org/obo/PR_000001024`
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ISBN:0198506732"
+#### Added
+- [neural cell adhesion molecule 1](http://purl.obolibrary.org/obo/PR_000001024) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [neural cell adhesion molecule 1 (human)](http://purl.obolibrary.org/obo/PR_P13591)
-- Class: [nucleoside diphosphate biosynthetic process](http://purl.obolibrary.org/obo/GO_0009133)
-- [nucleoside diphosphate biosynthetic process](http://purl.obolibrary.org/obo/GO_0009133) EquivalentTo [biosynthetic process](http://purl.obolibrary.org/obo/GO_0009058) and ([has primary output](http://purl.obolibrary.org/obo/RO_0004008) some [CHEBI_57930](http://purl.obolibrary.org/obo/CHEBI_57930))
+### neural crest derived neuron `http://purl.obolibrary.org/obo/CL_0000029`
+#### Removed
+- [neural crest derived neuron](http://purl.obolibrary.org/obo/CL_0000029) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [nucleoside diphosphate biosynthetic process](http://purl.obolibrary.org/obo/GO_0009133) SubClassOf [biosynthetic process](http://purl.obolibrary.org/obo/GO_0009058)
-- [nucleoside diphosphate biosynthetic process](http://purl.obolibrary.org/obo/GO_0009133) SubClassOf [nucleoside diphosphate metabolic process](http://purl.obolibrary.org/obo/GO_0009132)
-- [nucleoside diphosphate biosynthetic process](http://purl.obolibrary.org/obo/GO_0009133) SubClassOf [has primary output](http://purl.obolibrary.org/obo/RO_0004008) some [CHEBI_57930](http://purl.obolibrary.org/obo/CHEBI_57930)
+### neural plate `http://purl.obolibrary.org/obo/UBERON_0003075`
+#### Removed
+- [neural plate](http://purl.obolibrary.org/obo/UBERON_0003075) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-### nucleoside diphosphate catabolic process `http://purl.obolibrary.org/obo/GO_0009134`
-#### Added
-- [nucleoside diphosphate catabolic process](http://purl.obolibrary.org/obo/GO_0009134) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "nucleoside diphosphate catabolism"
+### neural stem cell `http://purl.obolibrary.org/obo/CL_0000047`
+#### Removed
+- [neural stem cell](http://purl.obolibrary.org/obo/CL_0000047) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [nucleoside diphosphate catabolic process](http://purl.obolibrary.org/obo/GO_0009134) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "nucleoside diphosphate degradation"
-- [nucleoside diphosphate catabolic process](http://purl.obolibrary.org/obo/GO_0009134) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process"
-- [nucleoside diphosphate catabolic process](http://purl.obolibrary.org/obo/GO_0009134) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "nucleoside diphosphate breakdown"
+### neural tissue `http://purl.obolibrary.org/obo/UBERON_0003714`
+#### Removed
+- [neural tissue](http://purl.obolibrary.org/obo/UBERON_0003714) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [nucleoside diphosphate catabolic process](http://purl.obolibrary.org/obo/GO_0009134) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The chemical reactions and pathways resulting in the breakdown of a nucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with diphosphate on the sugar."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:go_curators"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ISBN:0198506732"
-- [nucleoside diphosphate catabolic process](http://purl.obolibrary.org/obo/GO_0009134) [label](http://www.w3.org/2000/01/rdf-schema#label) "nucleoside diphosphate catabolic process"
+### neural tube basal plate `http://purl.obolibrary.org/obo/UBERON_0004064`
+#### Removed
+- [neural tube basal plate](http://purl.obolibrary.org/obo/UBERON_0004064) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-- [nucleoside diphosphate catabolic process](http://purl.obolibrary.org/obo/GO_0009134) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0009134"
-- Class: [nucleoside diphosphate catabolic process](http://purl.obolibrary.org/obo/GO_0009134)
-- [nucleoside diphosphate catabolic process](http://purl.obolibrary.org/obo/GO_0009134) EquivalentTo [catabolic process](http://purl.obolibrary.org/obo/GO_0009056) and ([has primary input](http://purl.obolibrary.org/obo/RO_0004009) some [CHEBI_57930](http://purl.obolibrary.org/obo/CHEBI_57930))
+### neural tube mantle layer `http://purl.obolibrary.org/obo/UBERON_0004061`
+#### Removed
+- [neural tube mantle layer](http://purl.obolibrary.org/obo/UBERON_0004061) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [nucleoside diphosphate catabolic process](http://purl.obolibrary.org/obo/GO_0009134) SubClassOf [has primary input](http://purl.obolibrary.org/obo/RO_0004009) some [CHEBI_57930](http://purl.obolibrary.org/obo/CHEBI_57930)
-- [nucleoside diphosphate catabolic process](http://purl.obolibrary.org/obo/GO_0009134) SubClassOf [catabolic process](http://purl.obolibrary.org/obo/GO_0009056)
-- [nucleoside diphosphate catabolic process](http://purl.obolibrary.org/obo/GO_0009134) SubClassOf [nucleoside diphosphate metabolic process](http://purl.obolibrary.org/obo/GO_0009132)
+### neural tube marginal layer `http://purl.obolibrary.org/obo/UBERON_0004062`
+#### Removed
+- [neural tube marginal layer](http://purl.obolibrary.org/obo/UBERON_0004062) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-### nucleoside diphosphate metabolic process `http://purl.obolibrary.org/obo/GO_0009132`
-#### Added
-- [nucleoside diphosphate metabolic process](http://purl.obolibrary.org/obo/GO_0009132) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process"
+### neurocranium `http://purl.obolibrary.org/obo/UBERON_0001703`
+#### Removed
+- [neurocranium](http://purl.obolibrary.org/obo/UBERON_0001703) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-- [nucleoside diphosphate metabolic process](http://purl.obolibrary.org/obo/GO_0009132) [label](http://www.w3.org/2000/01/rdf-schema#label) "nucleoside diphosphate metabolic process"
-- [nucleoside diphosphate metabolic process](http://purl.obolibrary.org/obo/GO_0009132) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "nucleoside diphosphate metabolism"
-- [nucleoside diphosphate metabolic process](http://purl.obolibrary.org/obo/GO_0009132) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The chemical reactions and pathways involving a nucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with diphosphate on the sugar."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:go_curators"
+### neurogenic placode `http://purl.obolibrary.org/obo/UBERON_0009955`
+#### Removed
+- [neurogenic placode](http://purl.obolibrary.org/obo/UBERON_0009955) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ISBN:0198506732"
-- [nucleoside diphosphate metabolic process](http://purl.obolibrary.org/obo/GO_0009132) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0009132"
-- Class: [nucleoside diphosphate metabolic process](http://purl.obolibrary.org/obo/GO_0009132)
+### neurogliaform lamp5 GABAergic cortical interneuron (Mmus) `http://purl.obolibrary.org/obo/CL_4023024`
-- [nucleoside diphosphate metabolic process](http://purl.obolibrary.org/obo/GO_0009132) EquivalentTo [metabolic process](http://purl.obolibrary.org/obo/GO_0008152) and ([has primary input or output](http://purl.obolibrary.org/obo/RO_0004007) some [CHEBI_57930](http://purl.obolibrary.org/obo/CHEBI_57930))
+#### Added
+- [neurogliaform lamp5 GABAergic cortical interneuron (Mmus)](http://purl.obolibrary.org/obo/CL_4023024) [symbol](http://purl.obolibrary.org/obo/IAO_0000028) "NGC Lamp5 interneuron (Mus)"
-- [nucleoside diphosphate metabolic process](http://purl.obolibrary.org/obo/GO_0009132) SubClassOf [has primary input or output](http://purl.obolibrary.org/obo/RO_0004007) some [CHEBI_57930](http://purl.obolibrary.org/obo/CHEBI_57930)
-- [nucleoside diphosphate metabolic process](http://purl.obolibrary.org/obo/GO_0009132) SubClassOf [metabolic process](http://purl.obolibrary.org/obo/GO_0008152)
+### neuromast hair cell `http://purl.obolibrary.org/obo/CL_0000856`
+#### Removed
+- [neuromast hair cell](http://purl.obolibrary.org/obo/CL_0000856) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-### nucleoside triphosphate biosynthetic process `http://purl.obolibrary.org/obo/GO_0009142`
-#### Added
-- [nucleoside triphosphate biosynthetic process](http://purl.obolibrary.org/obo/GO_0009142) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0009142"
+### neuron associated cell `http://purl.obolibrary.org/obo/CL_0000095`
+#### Removed
+- [neuron associated cell](http://purl.obolibrary.org/obo/CL_0000095) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [nucleoside triphosphate biosynthetic process](http://purl.obolibrary.org/obo/GO_0009142) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The chemical reactions and pathways resulting in the formation of a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:go_curators"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ISBN:0198506732"
-- [nucleoside triphosphate biosynthetic process](http://purl.obolibrary.org/obo/GO_0009142) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "nucleoside triphosphate biosynthesis"
+### neuron projection bundle `http://purl.obolibrary.org/obo/CARO_0001001`
+#### Removed
+- [neuron projection bundle](http://purl.obolibrary.org/obo/CARO_0001001) [label](http://www.w3.org/2000/01/rdf-schema#label) "neuron projection bundle"
-- [nucleoside triphosphate biosynthetic process](http://purl.obolibrary.org/obo/GO_0009142) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process"
+- [neuron projection bundle](http://purl.obolibrary.org/obo/CARO_0001001) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A fasciculated bundle of neuron projections (GO:0043005), largely or completely lacking synapses."
-- [nucleoside triphosphate biosynthetic process](http://purl.obolibrary.org/obo/GO_0009142) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "nucleoside triphosphate anabolism"
+- [neuron projection bundle](http://purl.obolibrary.org/obo/CARO_0001001) [id](http://www.geneontology.org/formats/oboInOwl#id) "CARO:0001001"
-- [nucleoside triphosphate biosynthetic process](http://purl.obolibrary.org/obo/GO_0009142) [label](http://www.w3.org/2000/01/rdf-schema#label) "nucleoside triphosphate biosynthetic process"
+- [neuron projection bundle](http://purl.obolibrary.org/obo/CARO_0001001) [IAO_0000118](http://purl.obolibrary.org/obo/IAO_0000118) "nerve fiber bundle"
+ - [IAO_scope](http://purl.obolibrary.org/obo/IAO_scope) "EXACT"
-- [nucleoside triphosphate biosynthetic process](http://purl.obolibrary.org/obo/GO_0009142) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "nucleoside triphosphate synthesis"
+- Class: [neuron projection bundle](http://purl.obolibrary.org/obo/CARO_0001001)
-- [nucleoside triphosphate biosynthetic process](http://purl.obolibrary.org/obo/GO_0009142) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "nucleoside triphosphate formation"
+- [neuron projection bundle](http://purl.obolibrary.org/obo/CARO_0001001) SubClassOf [bearer of](http://purl.obolibrary.org/obo/RO_0000053) some [fiber shaped](http://purl.obolibrary.org/obo/PATO_0002309)
-- Class: [nucleoside triphosphate biosynthetic process](http://purl.obolibrary.org/obo/GO_0009142)
+- [neuron projection bundle](http://purl.obolibrary.org/obo/CARO_0001001) SubClassOf [multi-cell-part structure](http://purl.obolibrary.org/obo/CARO_0001000)
-- [nucleoside triphosphate biosynthetic process](http://purl.obolibrary.org/obo/GO_0009142) EquivalentTo [biosynthetic process](http://purl.obolibrary.org/obo/GO_0009058) and ([has primary output](http://purl.obolibrary.org/obo/RO_0004008) some [CHEBI_61557](http://purl.obolibrary.org/obo/CHEBI_61557))
-- [nucleoside triphosphate biosynthetic process](http://purl.obolibrary.org/obo/GO_0009142) SubClassOf [biosynthetic process](http://purl.obolibrary.org/obo/GO_0009058)
-- [nucleoside triphosphate biosynthetic process](http://purl.obolibrary.org/obo/GO_0009142) SubClassOf [nucleoside triphosphate metabolic process](http://purl.obolibrary.org/obo/GO_0009141)
+### neuronal acetylcholine receptor subunit alpha-7 `http://purl.obolibrary.org/obo/PR_000005460`
-- [nucleoside triphosphate biosynthetic process](http://purl.obolibrary.org/obo/GO_0009142) SubClassOf [has primary output](http://purl.obolibrary.org/obo/RO_0004008) some [CHEBI_61557](http://purl.obolibrary.org/obo/CHEBI_61557)
+#### Added
+- [neuronal acetylcholine receptor subunit alpha-7](http://purl.obolibrary.org/obo/PR_000005460) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [neuronal acetylcholine receptor subunit alpha-7 (human)](http://purl.obolibrary.org/obo/PR_P36544)
-### nucleoside triphosphate catabolic process `http://purl.obolibrary.org/obo/GO_0009143`
+### neuropilin and tolloid-like protein 1 `http://purl.obolibrary.org/obo/PR_000011143`
#### Added
-- [nucleoside triphosphate catabolic process](http://purl.obolibrary.org/obo/GO_0009143) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "nucleoside triphosphate breakdown"
-
-- [nucleoside triphosphate catabolic process](http://purl.obolibrary.org/obo/GO_0009143) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "nucleoside triphosphate degradation"
+- [neuropilin and tolloid-like protein 1](http://purl.obolibrary.org/obo/PR_000011143) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [neuropilin and tolloid-like protein 1 (human)](http://purl.obolibrary.org/obo/PR_Q8TDF5)
-- [nucleoside triphosphate catabolic process](http://purl.obolibrary.org/obo/GO_0009143) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0009143"
-- [nucleoside triphosphate catabolic process](http://purl.obolibrary.org/obo/GO_0009143) [label](http://www.w3.org/2000/01/rdf-schema#label) "nucleoside triphosphate catabolic process"
+### neuroplacodal cell `http://purl.obolibrary.org/obo/CL_0000032`
+#### Removed
+- [neuroplacodal cell](http://purl.obolibrary.org/obo/CL_0000032) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [nucleoside triphosphate catabolic process](http://purl.obolibrary.org/obo/GO_0009143) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The chemical reactions and pathways resulting in the breakdown of a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:go_curators"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ISBN:0198506732"
-- [nucleoside triphosphate catabolic process](http://purl.obolibrary.org/obo/GO_0009143) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "nucleoside triphosphate catabolism"
+### neurula embryo `http://purl.obolibrary.org/obo/UBERON_0004455`
+#### Removed
+- [neurula embryo](http://purl.obolibrary.org/obo/UBERON_0004455) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [nucleoside triphosphate catabolic process](http://purl.obolibrary.org/obo/GO_0009143) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process"
-- Class: [nucleoside triphosphate catabolic process](http://purl.obolibrary.org/obo/GO_0009143)
-- [nucleoside triphosphate catabolic process](http://purl.obolibrary.org/obo/GO_0009143) EquivalentTo [catabolic process](http://purl.obolibrary.org/obo/GO_0009056) and ([has primary input](http://purl.obolibrary.org/obo/RO_0004009) some [CHEBI_61557](http://purl.obolibrary.org/obo/CHEBI_61557))
+### neurula stage `http://purl.obolibrary.org/obo/UBERON_0000110`
-- [nucleoside triphosphate catabolic process](http://purl.obolibrary.org/obo/GO_0009143) SubClassOf [nucleoside triphosphate metabolic process](http://purl.obolibrary.org/obo/GO_0009141)
+#### Added
+- [neurula stage](http://purl.obolibrary.org/obo/UBERON_0000110) [UBPROP_0000008](http://purl.obolibrary.org/obo/UBPROP_0000008) "In zebrafish, the times of neurulation and segmentation overlap so extensively there is no distinct neurula period of development, such as occurs largely before segmentation in amphibian embryos."
-- [nucleoside triphosphate catabolic process](http://purl.obolibrary.org/obo/GO_0009143) SubClassOf [catabolic process](http://purl.obolibrary.org/obo/GO_0009056)
+- [neurula stage](http://purl.obolibrary.org/obo/UBERON_0000110) [see also](http://www.w3.org/2000/01/rdf-schema#seeAlso) "https://github.com/obophenotype/developmental-stage-ontologies/issues/84"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI)
-- [nucleoside triphosphate catabolic process](http://purl.obolibrary.org/obo/GO_0009143) SubClassOf [has primary input](http://purl.obolibrary.org/obo/RO_0004009) some [CHEBI_61557](http://purl.obolibrary.org/obo/CHEBI_61557)
+- [neurula stage](http://purl.obolibrary.org/obo/UBERON_0000110) [RO_0002174](http://purl.obolibrary.org/obo/RO_0002174) [NCBITaxon_7955](http://purl.obolibrary.org/obo/NCBITaxon_7955)
-### nucleoside triphosphate metabolic process `http://purl.obolibrary.org/obo/GO_0009141`
+### neutrophil gelatinase-associated lipocalin `http://purl.obolibrary.org/obo/PR_000009725`
#### Added
-- [nucleoside triphosphate metabolic process](http://purl.obolibrary.org/obo/GO_0009141) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "nucleoside triphosphate metabolism"
+- [neutrophil gelatinase-associated lipocalin](http://purl.obolibrary.org/obo/PR_000009725) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [neutrophil gelatinase-associated lipocalin (human)](http://purl.obolibrary.org/obo/PR_P80188)
+
+
+### non-classical monocyte `http://purl.obolibrary.org/obo/CL_0000875`
+#### Removed
+- [non-classical monocyte](http://purl.obolibrary.org/obo/CL_0000875) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-- [nucleoside triphosphate metabolic process](http://purl.obolibrary.org/obo/GO_0009141) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process"
-- [nucleoside triphosphate metabolic process](http://purl.obolibrary.org/obo/GO_0009141) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0009141"
-- [nucleoside triphosphate metabolic process](http://purl.obolibrary.org/obo/GO_0009141) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The chemical reactions and pathways involving a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:go_curators"
+### non-medulla, extratelencephalic-projecting glutamatergic neuron of the primary motor cortex `http://purl.obolibrary.org/obo/CL_4023044`
+
+#### Added
+- [non-medulla, extratelencephalic-projecting glutamatergic neuron of the primary motor cortex](http://purl.obolibrary.org/obo/CL_4023044) [symbol](http://purl.obolibrary.org/obo/IAO_0000028) "non-MY ET glut MOp"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ISBN:0198506732"
-- [nucleoside triphosphate metabolic process](http://purl.obolibrary.org/obo/GO_0009141) [label](http://www.w3.org/2000/01/rdf-schema#label) "nucleoside triphosphate metabolic process"
+### non-secretory ribonuclease `http://purl.obolibrary.org/obo/PR_000014046`
-- Class: [nucleoside triphosphate metabolic process](http://purl.obolibrary.org/obo/GO_0009141)
+#### Added
+- [non-secretory ribonuclease](http://purl.obolibrary.org/obo/PR_000014046) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [non-secretory ribonuclease (human)](http://purl.obolibrary.org/obo/PR_P10153)
-- [nucleoside triphosphate metabolic process](http://purl.obolibrary.org/obo/GO_0009141) EquivalentTo [metabolic process](http://purl.obolibrary.org/obo/GO_0008152) and ([has primary input or output](http://purl.obolibrary.org/obo/RO_0004007) some [CHEBI_61557](http://purl.obolibrary.org/obo/CHEBI_61557))
-- [nucleoside triphosphate metabolic process](http://purl.obolibrary.org/obo/GO_0009141) SubClassOf [metabolic process](http://purl.obolibrary.org/obo/GO_0008152)
+### notochordal cell `http://purl.obolibrary.org/obo/CL_0007005`
+#### Removed
+- [notochordal cell](http://purl.obolibrary.org/obo/CL_0007005) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [nucleoside triphosphate metabolic process](http://purl.obolibrary.org/obo/GO_0009141) SubClassOf [has primary input or output](http://purl.obolibrary.org/obo/RO_0004007) some [CHEBI_61557](http://purl.obolibrary.org/obo/CHEBI_61557)
-### nucleus accumbens `http://purl.obolibrary.org/obo/UBERON_0001882`
+### notochordal process `http://purl.obolibrary.org/obo/UBERON_0006268`
+#### Removed
+- [notochordal process](http://purl.obolibrary.org/obo/UBERON_0006268) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-#### Added
-- [nucleus accumbens](http://purl.obolibrary.org/obo/UBERON_0001882) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "NCIT:C52733"
-- [nucleus accumbens](http://purl.obolibrary.org/obo/UBERON_0001882) [id](http://www.geneontology.org/formats/oboInOwl#id) "UBERON:0001882"
-- [nucleus accumbens](http://purl.obolibrary.org/obo/UBERON_0001882) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "BM:Ac"
+### nuclear factor NF-kappa-B p100 subunit `http://purl.obolibrary.org/obo/PR_000011178`
-- [nucleus accumbens](http://purl.obolibrary.org/obo/UBERON_0001882) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "MESH:D009714"
+#### Added
+- [nuclear factor NF-kappa-B p100 subunit](http://purl.obolibrary.org/obo/PR_000011178) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [nuclear factor NF-kappa-B p100 subunit (human)](http://purl.obolibrary.org/obo/PR_Q00653)
-- [nucleus accumbens](http://purl.obolibrary.org/obo/UBERON_0001882) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "DHBA:10339"
-- [nucleus accumbens](http://purl.obolibrary.org/obo/UBERON_0001882) [UBPROP_0000008](http://purl.obolibrary.org/obo/UBPROP_0000008) "The ventral striatopallidal complex in birds corresponds closely to its counterpart in mammals, with a nucleus accumbes present in the rostral telenceaphalon. Note that in birds, a region previously called the nucleus accumbens is now recognized as the lateral part of the bed nucleus of stria terminalis.[ISBN:0471888893]"
+### nuclear receptor ROR-gamma `http://purl.obolibrary.org/obo/PR_000001902`
-- [nucleus accumbens](http://purl.obolibrary.org/obo/UBERON_0001882) [RO_0002171](http://purl.obolibrary.org/obo/RO_0002171) [olfactory tubercle](http://purl.obolibrary.org/obo/UBERON_0001883)
- - [source](http://www.geneontology.org/formats/oboInOwl#source) "ABA"
+#### Added
+- [nuclear receptor ROR-gamma](http://purl.obolibrary.org/obo/PR_000001902) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [nuclear receptor ROR-gamma (human)](http://purl.obolibrary.org/obo/PR_P51449)
-- [nucleus accumbens](http://purl.obolibrary.org/obo/UBERON_0001882) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "UMLS:C0028633"
- - [source](http://www.geneontology.org/formats/oboInOwl#source) "ncithesaurus:Accumbens_Nucleus"
-- [nucleus accumbens](http://purl.obolibrary.org/obo/UBERON_0001882) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "EFO:0000906"
+### obsolescence reason specification `http://purl.obolibrary.org/obo/IAO_0000225`
-- [nucleus accumbens](http://purl.obolibrary.org/obo/UBERON_0001882) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "nucleus accumbens septi"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "FMA:61889"
+#### Added
+- [obsolescence reason specification](http://purl.obolibrary.org/obo/IAO_0000225) [IAO_0000117](http://purl.obolibrary.org/obo/IAO_0000117) "PERSON: Melanie Courtot"@en
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Wikipedia:Nucleus_accumbens"
+- [obsolescence reason specification](http://purl.obolibrary.org/obo/IAO_0000225) [IAO_0000117](http://purl.obolibrary.org/obo/IAO_0000117) "PERSON: Alan Ruttenberg"@en
-- [nucleus accumbens](http://purl.obolibrary.org/obo/UBERON_0001882) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "HBA:4290"
+- [obsolescence reason specification](http://purl.obolibrary.org/obo/IAO_0000225) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The reason for which a term has been deprecated. The allowed values come from an enumerated list of predefined terms. See the specification of these instances for more detailed definitions of each enumerated value."@en
-- [nucleus accumbens](http://purl.obolibrary.org/obo/UBERON_0001882) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "accumbens nucleus"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "FMA:61889"
+- [obsolescence reason specification](http://purl.obolibrary.org/obo/IAO_0000225) [label](http://www.w3.org/2000/01/rdf-schema#label) "obsolescence reason specification"@en
-- [nucleus accumbens](http://purl.obolibrary.org/obo/UBERON_0001882) [depicted by](http://xmlns.com/foaf/0.1/depicted_by) "http://upload.wikimedia.org/wikipedia/commons/9/93/Circuit_du_syst%C3%A8me_de_recompense.jpg"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI)
+- [obsolescence reason specification](http://purl.obolibrary.org/obo/IAO_0000225) [IAO_0000114](http://purl.obolibrary.org/obo/IAO_0000114) [pending final vetting](http://purl.obolibrary.org/obo/IAO_0000125)
-- [nucleus accumbens](http://purl.obolibrary.org/obo/UBERON_0001882) [present_in_taxon](http://purl.obolibrary.org/obo/RO_0002175) [Aves](http://purl.obolibrary.org/obo/NCBITaxon_8782)
- - [source](http://www.geneontology.org/formats/oboInOwl#source) "ISBN:0471888893"
+- [obsolescence reason specification](http://purl.obolibrary.org/obo/IAO_0000225) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "obsolescence reason specification"@en
-- [nucleus accumbens](http://purl.obolibrary.org/obo/UBERON_0001882) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "BAMS:Acb"
+- [obsolescence reason specification](http://purl.obolibrary.org/obo/IAO_0000225) [editor note](http://purl.obolibrary.org/obo/IAO_0000116) "The creation of this class has been inspired in part by Werner Ceusters' paper, Applying evolutionary terminology auditing to the Gene Ontology."@en
-- [nucleus accumbens](http://purl.obolibrary.org/obo/UBERON_0001882) [label](http://www.w3.org/2000/01/rdf-schema#label) "nucleus accumbens"
+- Class: [obsolescence reason specification](http://purl.obolibrary.org/obo/IAO_0000225)
-- [nucleus accumbens](http://purl.obolibrary.org/obo/UBERON_0001882) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A region of the brain consisting of a collection of neurons located in the forebrain ventral to the caudate and putamen. (caudoputamen in rodent) and continuous with these structures. There is no distinct boundary between the nucleus accumbens and the caudate/putamen, but in rodents, it can be identified by its lack of traversing fiber bundles in comparison to the dorsal striatum. Its principle neuron is the medium spiny neuron. Together with the neostriatum (caudate nucleus and putamen), the nucleus accumbens forms the striatum."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "BIRNLEX:727"
+- [obsolescence reason specification](http://purl.obolibrary.org/obo/IAO_0000225) EquivalentTo {[failed exploratory term](http://purl.obolibrary.org/obo/IAO_0000103) , [placeholder removed](http://purl.obolibrary.org/obo/IAO_0000226) , [terms merged](http://purl.obolibrary.org/obo/IAO_0000227) , [term imported](http://purl.obolibrary.org/obo/IAO_0000228) , [term split](http://purl.obolibrary.org/obo/IAO_0000229) , [OMO_0001000](http://purl.obolibrary.org/obo/OMO_0001000)}
-- [nucleus accumbens](http://purl.obolibrary.org/obo/UBERON_0001882) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [pheno_slim](http://purl.obolibrary.org/obo/uberon/core#pheno_slim)
+- [obsolescence reason specification](http://purl.obolibrary.org/obo/IAO_0000225) SubClassOf [data about an ontology part](http://purl.obolibrary.org/obo/IAO_0000102)
-- [nucleus accumbens](http://purl.obolibrary.org/obo/UBERON_0001882) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "BIRNLEX:727"
-- [nucleus accumbens](http://purl.obolibrary.org/obo/UBERON_0001882) [UBPROP_0000001](http://purl.obolibrary.org/obo/UBPROP_0000001) "a collection of pleomorphic cells in the caudal part of the anterior horn of the lateral ventricle, in the region of the olfactory tubercle, lying between the head of the caudate nucleus and the anterior perforated substance. It is part of the ventral striatum, a composite structure considered part of the basal ganglia[GO][GO:0021768]."
- - [source](http://www.geneontology.org/formats/oboInOwl#source) "GO:0021768"
+### occurs across `http://purl.obolibrary.org/obo/RO_0002021`
+#### Removed
+- [occurs across](http://purl.obolibrary.org/obo/RO_0002021) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "dos"
-- [nucleus accumbens](http://purl.obolibrary.org/obo/UBERON_0001882) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [efo_slim](http://purl.obolibrary.org/obo/uberon/core#efo_slim)
+#### Added
+- [occurs across](http://purl.obolibrary.org/obo/RO_0002021) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) [0000-0002-7073-9172](https://orcid.org/0000-0002-7073-9172)
-- [nucleus accumbens](http://purl.obolibrary.org/obo/UBERON_0001882) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "colliculus of caudate nucleus"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "FMA:61889"
-- [nucleus accumbens](http://purl.obolibrary.org/obo/UBERON_0001882) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "colliculus nuclei caudati"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "NeuroNames:277"
+### occurs in `http://purl.obolibrary.org/obo/BFO_0000066`
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [LATIN](http://purl.obolibrary.org/obo/uberon/core#LATIN)
+#### Added
+- [occurs in](http://purl.obolibrary.org/obo/BFO_0000066) [see also](http://www.w3.org/2000/01/rdf-schema#seeAlso) "https://wiki.geneontology.org/Occurs_in"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI)
-- [nucleus accumbens](http://purl.obolibrary.org/obo/UBERON_0001882) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [uberon_slim](http://purl.obolibrary.org/obo/uberon/core#uberon_slim)
-- [nucleus accumbens](http://purl.obolibrary.org/obo/UBERON_0001882) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "MAT:0000512"
+### octopus cell of the mammalian cochlear nucleus `http://purl.obolibrary.org/obo/CL_4023158`
+#### Removed
+- [octopus cell of the mammalian cochlear nucleus](http://purl.obolibrary.org/obo/CL_4023158) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [nucleus accumbens](http://purl.obolibrary.org/obo/UBERON_0001882) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "MBA:56"
-- [nucleus accumbens](http://purl.obolibrary.org/obo/UBERON_0001882) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PBA:10092"
-- [nucleus accumbens](http://purl.obolibrary.org/obo/UBERON_0001882) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "neuronames:277"
- - [source](http://www.geneontology.org/formats/oboInOwl#source) "BIRNLEX:727"
+### odontocyte `http://purl.obolibrary.org/obo/CL_0000140`
+#### Removed
+- [odontocyte](http://purl.obolibrary.org/obo/CL_0000140) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [nucleus accumbens](http://purl.obolibrary.org/obo/UBERON_0001882) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "BAMS:ACB"
-- [nucleus accumbens](http://purl.obolibrary.org/obo/UBERON_0001882) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "BAMS:ACC"
-- [nucleus accumbens](http://purl.obolibrary.org/obo/UBERON_0001882) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "MA:0000892"
+### olfactory bulb interneuron `http://purl.obolibrary.org/obo/CL_1001434`
+#### Removed
+- [olfactory bulb interneuron](http://purl.obolibrary.org/obo/CL_1001434) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [nucleus accumbens](http://purl.obolibrary.org/obo/UBERON_0001882) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Wikipedia:Nucleus_accumbens"
-- [nucleus accumbens](http://purl.obolibrary.org/obo/UBERON_0001882) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "EMAPA:32789"
-- [nucleus accumbens](http://purl.obolibrary.org/obo/UBERON_0001882) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "BTO:0001862"
+### olfactory bulb tufted cell `http://purl.obolibrary.org/obo/CL_1001503`
+#### Removed
+- [olfactory bulb tufted cell](http://purl.obolibrary.org/obo/CL_1001503) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [nucleus accumbens](http://purl.obolibrary.org/obo/UBERON_0001882) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "FMA:61889"
-- [nucleus accumbens](http://purl.obolibrary.org/obo/UBERON_0001882) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "EHDAA2:0004707"
-- [nucleus accumbens](http://purl.obolibrary.org/obo/UBERON_0001882) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "uberon"
+### olfactory nerve `http://purl.obolibrary.org/obo/UBERON_0001579`
+#### Removed
+- [olfactory nerve](http://purl.obolibrary.org/obo/UBERON_0001579) SubClassOf [neuron projection bundle](http://purl.obolibrary.org/obo/CARO_0001001)
-- [nucleus accumbens](http://purl.obolibrary.org/obo/UBERON_0001882) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GAID:672"
-- [nucleus accumbens](http://purl.obolibrary.org/obo/UBERON_0001882) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "SCTID:427667007"
-- Class: [nucleus accumbens](http://purl.obolibrary.org/obo/UBERON_0001882)
+### olfactory pit `http://purl.obolibrary.org/obo/UBERON_0005870`
+#### Removed
+- [olfactory pit](http://purl.obolibrary.org/obo/UBERON_0005870) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [nucleus accumbens](http://purl.obolibrary.org/obo/UBERON_0001882) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [limbic system](http://purl.obolibrary.org/obo/UBERON_0000349)
- - [source](http://www.geneontology.org/formats/oboInOwl#source) "FMA"
- - [source](http://www.geneontology.org/formats/oboInOwl#source) "GO"
-- [nucleus accumbens](http://purl.obolibrary.org/obo/UBERON_0001882) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [ventral striatum](http://purl.obolibrary.org/obo/UBERON_0005403)
- - [source](http://www.geneontology.org/formats/oboInOwl#source) "MA"
+### olfactory segment of nasal mucosa `http://purl.obolibrary.org/obo/UBERON_0005386`
+#### Removed
+- [olfactory segment of nasal mucosa](http://purl.obolibrary.org/obo/UBERON_0005386) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [nucleus accumbens](http://purl.obolibrary.org/obo/UBERON_0001882) SubClassOf [telencephalic nucleus](http://purl.obolibrary.org/obo/UBERON_0009663)
-- [nucleus accumbens](http://purl.obolibrary.org/obo/UBERON_0001882) SubClassOf [contributes to morphology of](http://purl.obolibrary.org/obo/RO_0002433) some [ventral striatum](http://purl.obolibrary.org/obo/UBERON_0005403)
-- [nucleus accumbens](http://purl.obolibrary.org/obo/UBERON_0001882) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [cerebral hemisphere](http://purl.obolibrary.org/obo/UBERON_0001869)
+### oogonial cell `http://purl.obolibrary.org/obo/CL_0000024`
+#### Removed
+- [oogonial cell](http://purl.obolibrary.org/obo/CL_0000024) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-### nucleus accumbens development `http://purl.obolibrary.org/obo/GO_0021768`
-#### Added
-- [nucleus accumbens development](http://purl.obolibrary.org/obo/GO_0021768) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "ventral striatum development"
+### ophthalmic nerve `http://purl.obolibrary.org/obo/UBERON_0000348`
+#### Removed
+- [ophthalmic nerve](http://purl.obolibrary.org/obo/UBERON_0000348) SubClassOf [neuron projection bundle](http://purl.obolibrary.org/obo/CARO_0001001)
-- [nucleus accumbens development](http://purl.obolibrary.org/obo/GO_0021768) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The progression of the nucleus accumbens over time from its initial formation until its mature state. The nucleus accumbens is a collection of pleomorphic cells in the caudal part of the anterior horn of the lateral ventricle, in the region of the olfactory tubercle, lying between the head of the caudate nucleus and the anterior perforated substance. It is part of the ventral striatum, a composite structure considered part of the basal ganglia."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dph"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:jid"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GO_REF:0000021"
+### optic cup `http://purl.obolibrary.org/obo/UBERON_0003072`
+#### Removed
+- [optic cup](http://purl.obolibrary.org/obo/UBERON_0003072) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dgh"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:cls"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ISBN:0878937420"
+### optic tract `http://purl.obolibrary.org/obo/UBERON_0001908`
+#### Removed
+- [optic tract](http://purl.obolibrary.org/obo/UBERON_0001908) SubClassOf [neuron projection bundle](http://purl.obolibrary.org/obo/CARO_0001001)
-- [nucleus accumbens development](http://purl.obolibrary.org/obo/GO_0021768) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process"
-- [nucleus accumbens development](http://purl.obolibrary.org/obo/GO_0021768) [label](http://www.w3.org/2000/01/rdf-schema#label) "nucleus accumbens development"
-- [nucleus accumbens development](http://purl.obolibrary.org/obo/GO_0021768) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0021768"
+### optic vesicle `http://purl.obolibrary.org/obo/UBERON_0004128`
+#### Removed
+- [optic vesicle](http://purl.obolibrary.org/obo/UBERON_0004128) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-- [nucleus accumbens development](http://purl.obolibrary.org/obo/GO_0021768) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "accumbens nucleus development"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dgh"
-- Class: [nucleus accumbens development](http://purl.obolibrary.org/obo/GO_0021768)
-- [nucleus accumbens development](http://purl.obolibrary.org/obo/GO_0021768) EquivalentTo [anatomical structure development](http://purl.obolibrary.org/obo/GO_0048856) and ([results in development of](http://purl.obolibrary.org/obo/RO_0002296) some [nucleus accumbens](http://purl.obolibrary.org/obo/UBERON_0001882))
+### organizational term `http://purl.obolibrary.org/obo/IAO_0000121`
-- [nucleus accumbens development](http://purl.obolibrary.org/obo/GO_0021768) SubClassOf [results in development of](http://purl.obolibrary.org/obo/RO_0002296) some [nucleus accumbens](http://purl.obolibrary.org/obo/UBERON_0001882)
+#### Added
+- [organizational term](http://purl.obolibrary.org/obo/IAO_0000121) [label](http://www.w3.org/2000/01/rdf-schema#label) "organizational term"@en
-- [nucleus accumbens development](http://purl.obolibrary.org/obo/GO_0021768) SubClassOf [neural nucleus development](http://purl.obolibrary.org/obo/GO_0048857)
+- [organizational term](http://purl.obolibrary.org/obo/IAO_0000121) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "organizational term"@en
-- [nucleus accumbens development](http://purl.obolibrary.org/obo/GO_0021768) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [limbic system development](http://purl.obolibrary.org/obo/GO_0021761)
+- [organizational term](http://purl.obolibrary.org/obo/IAO_0000121) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Term created to ease viewing/sort terms for development purpose, and will not be included in a release"@en
-- [nucleus accumbens development](http://purl.obolibrary.org/obo/GO_0021768) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [striatum development](http://purl.obolibrary.org/obo/GO_0021756)
+- Individual: [organizational term](http://purl.obolibrary.org/obo/IAO_0000121)
-### nucleus accumbens shell and olfactory tubercle D1 medium spiny neuron `http://purl.obolibrary.org/obo/CL_4030051`
+### organogenesis stage `http://purl.obolibrary.org/obo/UBERON_0000111`
+#### Removed
+- [organogenesis stage](http://purl.obolibrary.org/obo/UBERON_0000111) SubClassOf [preceded by](http://purl.obolibrary.org/obo/BFO_0000062) some [neurula stage](http://purl.obolibrary.org/obo/UBERON_0000110)
#### Added
-- [nucleus accumbens shell and olfactory tubercle D1 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030051) [date](http://purl.org/dc/terms/date) "2023-06-14T13:03:50Z"^^[dateTime](http://www.w3.org/2001/XMLSchema#dateTime)
-
-- [nucleus accumbens shell and olfactory tubercle D1 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030051) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "NAc shell and OT D1 medium spiny neuron"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/j.cub.2021.10.015"
+- [organogenesis stage](http://purl.obolibrary.org/obo/UBERON_0000111) [see also](http://www.w3.org/2000/01/rdf-schema#seeAlso) "https://github.com/obophenotype/developmental-stage-ontologies/issues/84"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI)
-- [nucleus accumbens shell and olfactory tubercle D1 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030051) [label](http://www.w3.org/2000/01/rdf-schema#label) "nucleus accumbens shell and olfactory tubercle D1 medium spiny neuron"
-- [nucleus accumbens shell and olfactory tubercle D1 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030051) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A DRD1-expressing medium spiny neuron that is part of a nucleus accumbens shell or olfactory tubercle."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/j.cub.2021.10.015"
-
-- [nucleus accumbens shell and olfactory tubercle D1 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030051) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "D1Sh"
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
+### osteoclast `http://purl.obolibrary.org/obo/CL_0000092`
+#### Removed
+- [osteoclast](http://purl.obolibrary.org/obo/CL_0000092) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/j.cub.2021.10.015"
-- [nucleus accumbens shell and olfactory tubercle D1 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030051) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "In Rhesus macaques, both nucleus accumbens shell and olfactory tubercle D1 and D2 medium spiny neuron cell types have been noted to have enriched gene expression of the following: GREB1L, ARHGAP6, and GRIA4."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/j.cub.2021.10.015"
-- [nucleus accumbens shell and olfactory tubercle D1 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030051) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "NAc shell and OT D1-MSN"
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
+### osteocyte `http://purl.obolibrary.org/obo/CL_0000137`
+#### Removed
+- [osteocyte](http://purl.obolibrary.org/obo/CL_0000137) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/j.cub.2021.10.015"
-- Class: [nucleus accumbens shell and olfactory tubercle D1 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030051)
-- [nucleus accumbens shell and olfactory tubercle D1 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030051) SubClassOf [expresses](http://purl.obolibrary.org/obo/RO_0002292) some [D(1A) dopamine receptor](http://purl.obolibrary.org/obo/PR_000001175)
+### otic pit `http://purl.obolibrary.org/obo/UBERON_0006273`
+#### Removed
+- [otic pit](http://purl.obolibrary.org/obo/UBERON_0006273) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [nucleus accumbens shell and olfactory tubercle D1 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030051) SubClassOf [has soma location](http://purl.obolibrary.org/obo/RO_0002100) some [ventral striatum](http://purl.obolibrary.org/obo/UBERON_0005403)
-- [nucleus accumbens shell and olfactory tubercle D1 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030051) SubClassOf [medium spiny neuron](http://purl.obolibrary.org/obo/CL_1001474)
+### otocyst lumen `http://purl.obolibrary.org/obo/UBERON_0013526`
+#### Removed
+- [otocyst lumen](http://purl.obolibrary.org/obo/UBERON_0013526) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-### nucleus accumbens shell and olfactory tubercle D2 medium spiny neuron `http://purl.obolibrary.org/obo/CL_4030052`
-#### Added
-- [nucleus accumbens shell and olfactory tubercle D2 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030052) [label](http://www.w3.org/2000/01/rdf-schema#label) "nucleus accumbens shell and olfactory tubercle D2 medium spiny neuron"
-- [nucleus accumbens shell and olfactory tubercle D2 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030052) [date](http://purl.org/dc/terms/date) "2023-06-14T13:27:51Z"^^[dateTime](http://www.w3.org/2001/XMLSchema#dateTime)
+### outer epithelium `http://purl.obolibrary.org/obo/UBERON_0007376`
+#### Removed
+- [outer epithelium](http://purl.obolibrary.org/obo/UBERON_0007376) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [nucleus accumbens shell and olfactory tubercle D2 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030052) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "NAc shell and OT D2-MSN"
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/j.cub.2021.10.015"
-- [nucleus accumbens shell and olfactory tubercle D2 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030052) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "NAc shell and OT D2 medium spiny neuron"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/j.cub.2021.10.015"
+### outflow part of right ventricle `http://purl.obolibrary.org/obo/UBERON_0005953`
+#### Removed
+- [outflow part of right ventricle](http://purl.obolibrary.org/obo/UBERON_0005953) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [nucleus accumbens shell and olfactory tubercle D2 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030052) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "nucleus accumbens shell and olfactory tubercle D2-MSN"
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/j.cub.2021.10.015"
-- [nucleus accumbens shell and olfactory tubercle D2 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030052) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "In Rhesus macaques, both nucleus accumbens shell and olfactory tubercle D1 and D2 medium spiny neuron cell types have been noted to have enriched gene expression of the following: GREB1L, ARHGAP6, and GRIA4."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/j.cub.2021.10.015"
+### ovary stroma `http://purl.obolibrary.org/obo/UBERON_0006960`
+#### Removed
+- [ovary stroma](http://purl.obolibrary.org/obo/UBERON_0006960) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [nucleus accumbens shell and olfactory tubercle D2 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030052) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A DRD2-expressing medium spiny neuron that is part of a nucleus accumbens shell or olfactory tubercle."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/j.cub.2021.10.015"
-- [nucleus accumbens shell and olfactory tubercle D2 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030052) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "D2Sh"
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/j.cub.2021.10.015"
+### oxytocin receptor `http://purl.obolibrary.org/obo/PR_000001635`
-- Class: [nucleus accumbens shell and olfactory tubercle D2 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030052)
+#### Added
+- [oxytocin receptor](http://purl.obolibrary.org/obo/PR_000001635) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [oxytocin receptor (human)](http://purl.obolibrary.org/obo/PR_P30559)
-- [nucleus accumbens shell and olfactory tubercle D2 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030052) SubClassOf [has soma location](http://purl.obolibrary.org/obo/RO_0002100) some [ventral striatum](http://purl.obolibrary.org/obo/UBERON_0005403)
-- [nucleus accumbens shell and olfactory tubercle D2 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030052) SubClassOf [medium spiny neuron](http://purl.obolibrary.org/obo/CL_1001474)
+### pair of lungs `http://purl.obolibrary.org/obo/UBERON_0000170`
+#### Removed
+- [pair of lungs](http://purl.obolibrary.org/obo/UBERON_0000170) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-- [nucleus accumbens shell and olfactory tubercle D2 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030052) SubClassOf [expresses](http://purl.obolibrary.org/obo/RO_0002292) some [D(2) dopamine receptor](http://purl.obolibrary.org/obo/PR_000001177)
-### nucleus of lateral olfactory tract `http://purl.obolibrary.org/obo/UBERON_0002893`
+### paired box protein PAX-5 `http://purl.obolibrary.org/obo/PR_000001903`
#### Added
-- [nucleus of lateral olfactory tract](http://purl.obolibrary.org/obo/UBERON_0002893) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "lateral olfactory tract nucleus"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "FMA:61865"
+- [paired box protein PAX-5](http://purl.obolibrary.org/obo/PR_000001903) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [paired box protein Pax-5 (human)](http://purl.obolibrary.org/obo/PR_Q02548)
+
-- [nucleus of lateral olfactory tract](http://purl.obolibrary.org/obo/UBERON_0002893) [RO_0002171](http://purl.obolibrary.org/obo/RO_0002171) [UBERON_0002590](http://purl.obolibrary.org/obo/UBERON_0002590)
- - [source](http://www.geneontology.org/formats/oboInOwl#source) "ABA"
+### paired limb/fin `http://purl.obolibrary.org/obo/UBERON_0004708`
+#### Removed
+- [paired limb/fin](http://purl.obolibrary.org/obo/UBERON_0004708) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000)
-- [nucleus of lateral olfactory tract](http://purl.obolibrary.org/obo/UBERON_0002893) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "nucleus of the olfactory tract"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "BAMS:LOT"
-- [nucleus of lateral olfactory tract](http://purl.obolibrary.org/obo/UBERON_0002893) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "DMBA:15951"
-- [nucleus of lateral olfactory tract](http://purl.obolibrary.org/obo/UBERON_0002893) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "DHBA:10309"
+### paired limb/fin bud `http://purl.obolibrary.org/obo/UBERON_0004357`
+#### Removed
+- [paired limb/fin bud](http://purl.obolibrary.org/obo/UBERON_0004357) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-- [nucleus of lateral olfactory tract](http://purl.obolibrary.org/obo/UBERON_0002893) [RO_0002171](http://purl.obolibrary.org/obo/RO_0002171) [UBERON_0002266](http://purl.obolibrary.org/obo/UBERON_0002266)
- - [source](http://www.geneontology.org/formats/oboInOwl#source) "ABA"
-- [nucleus of lateral olfactory tract](http://purl.obolibrary.org/obo/UBERON_0002893) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "BAMS:LOT"
-- [nucleus of lateral olfactory tract](http://purl.obolibrary.org/obo/UBERON_0002893) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "BIRNLEX:2702"
+### paired limb/fin field `http://purl.obolibrary.org/obo/UBERON_0005732`
+#### Removed
+- [paired limb/fin field](http://purl.obolibrary.org/obo/UBERON_0005732) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [nucleus of lateral olfactory tract](http://purl.obolibrary.org/obo/UBERON_0002893) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "part of amygdala in FMA but this leads to inconsistency when combined with ABA partitions"
-- [nucleus of lateral olfactory tract](http://purl.obolibrary.org/obo/UBERON_0002893) [id](http://www.geneontology.org/formats/oboInOwl#id) "UBERON:0002893"
-- [nucleus of lateral olfactory tract](http://purl.obolibrary.org/obo/UBERON_0002893) [label](http://www.w3.org/2000/01/rdf-schema#label) "nucleus of lateral olfactory tract"
+### paired limb/fin skeleton `http://purl.obolibrary.org/obo/UBERON_0011582`
+#### Removed
+- [paired limb/fin skeleton](http://purl.obolibrary.org/obo/UBERON_0011582) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000)
-- [nucleus of lateral olfactory tract](http://purl.obolibrary.org/obo/UBERON_0002893) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "EMAPA:35599"
-- [nucleus of lateral olfactory tract](http://purl.obolibrary.org/obo/UBERON_0002893) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "BAMS:NLOT"
-- [nucleus of lateral olfactory tract](http://purl.obolibrary.org/obo/UBERON_0002893) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "FMA:61865"
+### palatoquadrate arch `http://purl.obolibrary.org/obo/UBERON_0011085`
+#### Removed
+- [palatoquadrate arch](http://purl.obolibrary.org/obo/UBERON_0011085) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [nucleus of lateral olfactory tract](http://purl.obolibrary.org/obo/UBERON_0002893) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "NLOT"
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [ABBREVIATION](http://purl.obolibrary.org/obo/uberon/core#ABBREVIATION)
-- [nucleus of lateral olfactory tract](http://purl.obolibrary.org/obo/UBERON_0002893) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "nucleus of tractus olfactorius lateralis"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "NeuroNames:242"
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [LATIN](http://purl.obolibrary.org/obo/uberon/core#LATIN)
+### pancreatic acinus `http://purl.obolibrary.org/obo/UBERON_0001263`
+#### Removed
+- [pancreatic acinus](http://purl.obolibrary.org/obo/UBERON_0001263) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [nucleus of lateral olfactory tract](http://purl.obolibrary.org/obo/UBERON_0002893) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "UMLS:C0175218"
- - [source](http://www.geneontology.org/formats/oboInOwl#source) "BIRNLEX:2702"
-- [nucleus of lateral olfactory tract](http://purl.obolibrary.org/obo/UBERON_0002893) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "uberon"
-- [nucleus of lateral olfactory tract](http://purl.obolibrary.org/obo/UBERON_0002893) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "nucleus striae olfactoriae lateralis"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "NeuroNames:242"
+### pancreatic lobule `http://purl.obolibrary.org/obo/UBERON_0007324`
+#### Removed
+- [pancreatic lobule](http://purl.obolibrary.org/obo/UBERON_0007324) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [LATIN](http://purl.obolibrary.org/obo/uberon/core#LATIN)
-- [nucleus of lateral olfactory tract](http://purl.obolibrary.org/obo/UBERON_0002893) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "neuronames:242"
- - [source](http://www.geneontology.org/formats/oboInOwl#source) "BIRNLEX:2702"
-- [nucleus of lateral olfactory tract](http://purl.obolibrary.org/obo/UBERON_0002893) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "nucleus of the lateral olfactory tract"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "NeuroNames:242"
+### papillary layer of dermis `http://purl.obolibrary.org/obo/UBERON_0001992`
+#### Removed
+- [papillary layer of dermis](http://purl.obolibrary.org/obo/UBERON_0001992) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [nucleus of lateral olfactory tract](http://purl.obolibrary.org/obo/UBERON_0002893) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "MBA:619"
-- [nucleus of lateral olfactory tract](http://purl.obolibrary.org/obo/UBERON_0002893) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "BM:Tel-NLOT"
-- [nucleus of lateral olfactory tract](http://purl.obolibrary.org/obo/UBERON_0002893) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "HBA:4385"
+### parafollicular cell `http://purl.obolibrary.org/obo/CL_0000570`
+#### Removed
+- [parafollicular cell](http://purl.obolibrary.org/obo/CL_0000570) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-- [nucleus of lateral olfactory tract](http://purl.obolibrary.org/obo/UBERON_0002893) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "nucleus of the lateral olfactory tract (ganser)"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "BIRNLEX:2702"
-- [nucleus of lateral olfactory tract](http://purl.obolibrary.org/obo/UBERON_0002893) [RO_0002171](http://purl.obolibrary.org/obo/RO_0002171) [UBERON_0004069](http://purl.obolibrary.org/obo/UBERON_0004069)
- - [source](http://www.geneontology.org/formats/oboInOwl#source) "ABA"
-- Class: [nucleus of lateral olfactory tract](http://purl.obolibrary.org/obo/UBERON_0002893)
+### parasympathetic nerve `http://purl.obolibrary.org/obo/UBERON_0004293`
+#### Removed
+- [parasympathetic nerve](http://purl.obolibrary.org/obo/UBERON_0004293) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [nucleus of lateral olfactory tract](http://purl.obolibrary.org/obo/UBERON_0002893) EquivalentTo [nucleus of brain](http://purl.obolibrary.org/obo/UBERON_0002308) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [olfactory cortex](http://purl.obolibrary.org/obo/UBERON_0002894)) and ([extends_fibers_into](http://purl.obolibrary.org/obo/uberon/core#extends_fibers_into) some [lateral olfactory stria](http://purl.obolibrary.org/obo/UBERON_0001888))
-- [nucleus of lateral olfactory tract](http://purl.obolibrary.org/obo/UBERON_0002893) SubClassOf [extends_fibers_into](http://purl.obolibrary.org/obo/uberon/core#extends_fibers_into) some [lateral olfactory stria](http://purl.obolibrary.org/obo/UBERON_0001888)
-- [nucleus of lateral olfactory tract](http://purl.obolibrary.org/obo/UBERON_0002893) SubClassOf [telencephalic nucleus](http://purl.obolibrary.org/obo/UBERON_0009663)
+### parenchyma of parathyroid gland `http://purl.obolibrary.org/obo/UBERON_0001749`
+#### Removed
+- [parenchyma of parathyroid gland](http://purl.obolibrary.org/obo/UBERON_0001749) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [nucleus of lateral olfactory tract](http://purl.obolibrary.org/obo/UBERON_0002893) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [olfactory cortex](http://purl.obolibrary.org/obo/UBERON_0002894)
-### olfactory cortex `http://purl.obolibrary.org/obo/UBERON_0002894`
+### parenchyma of thyroid gland `http://purl.obolibrary.org/obo/UBERON_0001747`
+#### Removed
+- [parenchyma of thyroid gland](http://purl.obolibrary.org/obo/UBERON_0001747) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-#### Added
-- [olfactory cortex](http://purl.obolibrary.org/obo/UBERON_0002894) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "EMAPA:17779"
-- [olfactory cortex](http://purl.obolibrary.org/obo/UBERON_0002894) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "FMA:276600"
-- [olfactory cortex](http://purl.obolibrary.org/obo/UBERON_0002894) [label](http://www.w3.org/2000/01/rdf-schema#label) "olfactory cortex"
+### parietal peritoneum `http://purl.obolibrary.org/obo/UBERON_0001366`
+#### Removed
+- [parietal peritoneum](http://purl.obolibrary.org/obo/UBERON_0001366) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000)
-- [olfactory cortex](http://purl.obolibrary.org/obo/UBERON_0002894) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "UMLS:C0162434"
- - [source](http://www.geneontology.org/formats/oboInOwl#source) "BIRNLEX:2707"
-- [olfactory cortex](http://purl.obolibrary.org/obo/UBERON_0002894) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [pheno_slim](http://purl.obolibrary.org/obo/uberon/core#pheno_slim)
-- [olfactory cortex](http://purl.obolibrary.org/obo/UBERON_0002894) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "MESH:D066194"
+### parietal pleura `http://purl.obolibrary.org/obo/UBERON_0002400`
+#### Removed
+- [parietal pleura](http://purl.obolibrary.org/obo/UBERON_0002400) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000)
-- [olfactory cortex](http://purl.obolibrary.org/obo/UBERON_0002894) [id](http://www.geneontology.org/formats/oboInOwl#id) "UBERON:0002894"
-- [olfactory cortex](http://purl.obolibrary.org/obo/UBERON_0002894) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "uberon"
-- [olfactory cortex](http://purl.obolibrary.org/obo/UBERON_0002894) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "olfactory lobe"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "MA:0000193"
+### part_of `http://purl.obolibrary.org/obo/BFO_0000050`
-- [olfactory cortex](http://purl.obolibrary.org/obo/UBERON_0002894) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "archeocortex"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "BTO:0001446"
+#### Added
+- [part_of](http://purl.obolibrary.org/obo/BFO_0000050) [see also](http://www.w3.org/2000/01/rdf-schema#seeAlso) "https://wiki.geneontology.org/Part_of"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI)
-- [olfactory cortex](http://purl.obolibrary.org/obo/UBERON_0002894) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "HBA:265504406"
-- [olfactory cortex](http://purl.obolibrary.org/obo/UBERON_0002894) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "neuronames:2275"
+### parvalbumin alpha `http://purl.obolibrary.org/obo/PR_000013502`
-- [olfactory cortex](http://purl.obolibrary.org/obo/UBERON_0002894) [UBPROP_0000001](http://purl.obolibrary.org/obo/UBPROP_0000001) "That portion of the cerebral cortex that, with the palaeocortex, develops in association with the olfactory system, and which is phylogenetically older than the neocortex and lacks its layered structure. The embryonic archaeocortex corresponds to the cortex of the dentate gyrus and hippocampus in mature mammals[BTO:0001446]."
- - [source](http://www.geneontology.org/formats/oboInOwl#source) "BTO:0001446"
+#### Added
+- [parvalbumin alpha](http://purl.obolibrary.org/obo/PR_000013502) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [parvalbumin alpha (human)](http://purl.obolibrary.org/obo/PR_P20472)
-- [olfactory cortex](http://purl.obolibrary.org/obo/UBERON_0002894) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "EHDAA:5482"
-- [olfactory cortex](http://purl.obolibrary.org/obo/UBERON_0002894) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "VHOG:0000325"
+### parvocellular layer of dorsal nucleus of lateral geniculate body `http://purl.obolibrary.org/obo/UBERON_0013607`
+#### Removed
+- [parvocellular layer of dorsal nucleus of lateral geniculate body](http://purl.obolibrary.org/obo/UBERON_0013607) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [olfactory cortex](http://purl.obolibrary.org/obo/UBERON_0002894) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "olfactory areas"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "BAMS:OLF"
-- [olfactory cortex](http://purl.obolibrary.org/obo/UBERON_0002894) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Aggregate brain region defined as those areas of cerebral cortex receiving direct synaptic input from the olfactory bulb (Price, 1973). It usually includes the piriform cortex and sometimes other areas."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "BIRNLEX:2707"
-- [olfactory cortex](http://purl.obolibrary.org/obo/UBERON_0002894) [editor note](http://purl.obolibrary.org/obo/IAO_0000116) "consider relationship: receives_input_from UBERON:0002264 olfactory bulb"
+### pectoral appendage bud ectoderm `http://purl.obolibrary.org/obo/UBERON_0003372`
+#### Removed
+- [pectoral appendage bud ectoderm](http://purl.obolibrary.org/obo/UBERON_0003372) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [olfactory cortex](http://purl.obolibrary.org/obo/UBERON_0002894) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "MA:0000193"
-- [olfactory cortex](http://purl.obolibrary.org/obo/UBERON_0002894) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [uberon_slim](http://purl.obolibrary.org/obo/uberon/core#uberon_slim)
-- [olfactory cortex](http://purl.obolibrary.org/obo/UBERON_0002894) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "archaeocortex"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "BTO:0001446"
+### pectoral complex `http://purl.obolibrary.org/obo/UBERON_0010708`
+#### Removed
+- [pectoral complex](http://purl.obolibrary.org/obo/UBERON_0010708) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000)
-- [olfactory cortex](http://purl.obolibrary.org/obo/UBERON_0002894) [UBPROP_0000001](http://purl.obolibrary.org/obo/UBPROP_0000001) "The olfactory cortex is involved in the perception of smell. It receives input from the olfactory bulb and is responsible for the identification of odors[GO][GO:0021989]."
- - [source](http://www.geneontology.org/formats/oboInOwl#source) "GO:0021989"
-- [olfactory cortex](http://purl.obolibrary.org/obo/UBERON_0002894) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "EHDAA2:0001289"
-- [olfactory cortex](http://purl.obolibrary.org/obo/UBERON_0002894) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "BIRNLEX:2707"
+### pedal digit epithelium `http://purl.obolibrary.org/obo/UBERON_0005226`
+#### Removed
+- [pedal digit epithelium](http://purl.obolibrary.org/obo/UBERON_0005226) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [olfactory cortex](http://purl.obolibrary.org/obo/UBERON_0002894) [UBPROP_0000003](http://purl.obolibrary.org/obo/UBPROP_0000003) "(In mammals) Odorant detection is mediated by millions of olfactory sensory neurons located in the olfactory epithelium lining the nasal cavity. These neurons transmit sensory signals to the olfactory bulb of the brain, which in turn sends signals to the olfactory cortex.[well established][VHOG]"
- - [source](http://www.geneontology.org/formats/oboInOwl#source) "DOI:10.1111/j.1753-4887.2004.tb00097.x Buck LB, Olfactory receptors and odor coding in mammals. Nutrition Reviews (2008)"
- - [source](http://www.geneontology.org/formats/oboInOwl#source) "http://bgee.unil.ch/"
- - [ontology](http://www.geneontology.org/formats/oboInOwl#ontology) "VHOG"
+### pedal digit mesenchyme `http://purl.obolibrary.org/obo/UBERON_0005255`
+#### Removed
+- [pedal digit mesenchyme](http://purl.obolibrary.org/obo/UBERON_0005255) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
- - [date_retrieved](http://www.geneontology.org/formats/oboInOwl#date_retrieved) "2012-09-17"
- - [external_class](http://www.geneontology.org/formats/oboInOwl#external_class) "VHOG:0000325"
-- [olfactory cortex](http://purl.obolibrary.org/obo/UBERON_0002894) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "BAMS:OLF"
+### pelvic appendage bud ectoderm `http://purl.obolibrary.org/obo/UBERON_0003371`
+#### Removed
+- [pelvic appendage bud ectoderm](http://purl.obolibrary.org/obo/UBERON_0003371) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [olfactory cortex](http://purl.obolibrary.org/obo/UBERON_0002894) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Wikipedia:Olfactory_cortex"
-- [olfactory cortex](http://purl.obolibrary.org/obo/UBERON_0002894) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "BTO:0001446"
-- Class: [olfactory cortex](http://purl.obolibrary.org/obo/UBERON_0002894)
+### pelvic complex `http://purl.obolibrary.org/obo/UBERON_0010709`
+#### Removed
+- [pelvic complex](http://purl.obolibrary.org/obo/UBERON_0010709) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000)
-- [olfactory cortex](http://purl.obolibrary.org/obo/UBERON_0002894) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [olfactory lobe](http://purl.obolibrary.org/obo/UBERON_0005366)
- - [source](http://www.geneontology.org/formats/oboInOwl#source) "MA"
-- [olfactory cortex](http://purl.obolibrary.org/obo/UBERON_0002894) SubClassOf [regional part of brain](http://purl.obolibrary.org/obo/UBERON_0002616)
-- [olfactory cortex](http://purl.obolibrary.org/obo/UBERON_0002894) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [cerebral cortex](http://purl.obolibrary.org/obo/UBERON_0000956)
- - [source](http://www.geneontology.org/formats/oboInOwl#source) "VHOG"
+### pelvic region of trunk `http://purl.obolibrary.org/obo/UBERON_0002355`
+#### Removed
+- [pelvic region of trunk](http://purl.obolibrary.org/obo/UBERON_0002355) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-- [olfactory cortex](http://purl.obolibrary.org/obo/UBERON_0002894) SubClassOf [contributes to morphology of](http://purl.obolibrary.org/obo/RO_0002433) some [olfactory lobe](http://purl.obolibrary.org/obo/UBERON_0005366)
-### olfactory cortex development `http://purl.obolibrary.org/obo/GO_0021989`
+### pending final vetting `http://purl.obolibrary.org/obo/IAO_0000125`
#### Added
-- [olfactory cortex development](http://purl.obolibrary.org/obo/GO_0021989) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process"
+- [pending final vetting](http://purl.obolibrary.org/obo/IAO_0000125) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "All definitions, placement in the asserted IS_A hierarchy and required minimal metadata are complete. The class is awaiting a final review by someone other than the term editor."@en
-- [olfactory cortex development](http://purl.obolibrary.org/obo/GO_0021989) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0021989"
+- [pending final vetting](http://purl.obolibrary.org/obo/IAO_0000125) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "pending final vetting"@en
-- [olfactory cortex development](http://purl.obolibrary.org/obo/GO_0021989) [label](http://www.w3.org/2000/01/rdf-schema#label) "olfactory cortex development"
+- [pending final vetting](http://purl.obolibrary.org/obo/IAO_0000125) [label](http://www.w3.org/2000/01/rdf-schema#label) "pending final vetting"@en
-- [olfactory cortex development](http://purl.obolibrary.org/obo/GO_0021989) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The progression of the olfactory cortex over time from its initial formation until its mature state. The olfactory cortex is involved in the perception of smell. It receives input from the olfactory bulb and is responsible for the identification of odors."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dph"
+- Individual: [pending final vetting](http://purl.obolibrary.org/obo/IAO_0000125)
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:jid"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GO_REF:0000021"
+### perforin-1 `http://purl.obolibrary.org/obo/PR_000003466`
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dgh"
+#### Added
+- [perforin-1](http://purl.obolibrary.org/obo/PR_000003466) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [perforin-1 (human)](http://purl.obolibrary.org/obo/PR_P14222)
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:cls"
-- Class: [olfactory cortex development](http://purl.obolibrary.org/obo/GO_0021989)
+### pericardium `http://purl.obolibrary.org/obo/UBERON_0002407`
+#### Removed
+- [pericardium](http://purl.obolibrary.org/obo/UBERON_0002407) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-- [olfactory cortex development](http://purl.obolibrary.org/obo/GO_0021989) EquivalentTo [anatomical structure development](http://purl.obolibrary.org/obo/GO_0048856) and ([results in development of](http://purl.obolibrary.org/obo/RO_0002296) some [olfactory cortex](http://purl.obolibrary.org/obo/UBERON_0002894))
-- [olfactory cortex development](http://purl.obolibrary.org/obo/GO_0021989) SubClassOf [anatomical structure development](http://purl.obolibrary.org/obo/GO_0048856)
-- [olfactory cortex development](http://purl.obolibrary.org/obo/GO_0021989) SubClassOf [results in development of](http://purl.obolibrary.org/obo/RO_0002296) some [olfactory cortex](http://purl.obolibrary.org/obo/UBERON_0002894)
+### periderm `http://purl.obolibrary.org/obo/UBERON_0003055`
+#### Removed
+- [periderm](http://purl.obolibrary.org/obo/UBERON_0003055) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [olfactory cortex development](http://purl.obolibrary.org/obo/GO_0021989) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [olfactory lobe development](http://purl.obolibrary.org/obo/GO_0021988)
-### olfactory cortex layer 1 `http://purl.obolibrary.org/obo/UBERON_0022317`
+### periodontium `http://purl.obolibrary.org/obo/UBERON_0001758`
+#### Removed
+- [periodontium](http://purl.obolibrary.org/obo/UBERON_0001758) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-#### Added
-- [olfactory cortex layer 1](http://purl.obolibrary.org/obo/UBERON_0022317) [label](http://www.w3.org/2000/01/rdf-schema#label) "olfactory cortex layer 1"
-- [olfactory cortex layer 1](http://purl.obolibrary.org/obo/UBERON_0022317) [id](http://www.geneontology.org/formats/oboInOwl#id) "UBERON:0022317"
-- [olfactory cortex layer 1](http://purl.obolibrary.org/obo/UBERON_0022317) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "layer 1 of olfactory cortex"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "NLX:152609"
+### peripheral blood mesothelial cell `http://purl.obolibrary.org/obo/CL_0002318`
+#### Removed
+- [peripheral blood mesothelial cell](http://purl.obolibrary.org/obo/CL_0002318) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
-- [olfactory cortex layer 1](http://purl.obolibrary.org/obo/UBERON_0022317) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "olfactory cortex plexiform layer"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "NLX:152609"
-- [olfactory cortex layer 1](http://purl.obolibrary.org/obo/UBERON_0022317) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "NLX:152609"
+### peritoneal cavity `http://purl.obolibrary.org/obo/UBERON_0001179`
+#### Removed
+- [peritoneal cavity](http://purl.obolibrary.org/obo/UBERON_0001179) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [olfactory cortex layer 1](http://purl.obolibrary.org/obo/UBERON_0022317) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Surface layer of the olfactory cortex that contains dendrites, fiber systems and a small number of neurons. It has been divided into a superficial part and a deep part."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "NLX:152609"
-- [olfactory cortex layer 1](http://purl.obolibrary.org/obo/UBERON_0022317) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "uberon"
-- Class: [olfactory cortex layer 1](http://purl.obolibrary.org/obo/UBERON_0022317)
+### peritoneal macrophage `http://purl.obolibrary.org/obo/CL_0000581`
+#### Removed
+- [peritoneal macrophage](http://purl.obolibrary.org/obo/CL_0000581) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-- [olfactory cortex layer 1](http://purl.obolibrary.org/obo/UBERON_0022317) EquivalentTo [nervous system cell part layer](http://purl.obolibrary.org/obo/UBERON_0022303) and ([bounding layer of](http://purl.obolibrary.org/obo/RO_0002007) some [olfactory cortex](http://purl.obolibrary.org/obo/UBERON_0002894))
-- [olfactory cortex layer 1](http://purl.obolibrary.org/obo/UBERON_0022317) SubClassOf [has part](http://purl.obolibrary.org/obo/BFO_0000051) some [nerve fiber](http://purl.obolibrary.org/obo/UBERON_0006134)
-- [olfactory cortex layer 1](http://purl.obolibrary.org/obo/UBERON_0022317) SubClassOf [central nervous system cell part cluster](http://purl.obolibrary.org/obo/UBERON_0011215)
+### perivascular macrophage `http://purl.obolibrary.org/obo/CL_0000881`
+#### Removed
+- [perivascular macrophage](http://purl.obolibrary.org/obo/CL_0000881) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-- [olfactory cortex layer 1](http://purl.obolibrary.org/obo/UBERON_0022317) SubClassOf [has part](http://purl.obolibrary.org/obo/BFO_0000051) some [dendrite](http://purl.obolibrary.org/obo/GO_0030425)
-- [olfactory cortex layer 1](http://purl.obolibrary.org/obo/UBERON_0022317) SubClassOf [nervous system cell part layer](http://purl.obolibrary.org/obo/UBERON_0022303)
-- [olfactory cortex layer 1](http://purl.obolibrary.org/obo/UBERON_0022317) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [olfactory cortex](http://purl.obolibrary.org/obo/UBERON_0002894)
- - [source](http://www.geneontology.org/formats/oboInOwl#source) "nlx"
+### pharyngeal arch `http://purl.obolibrary.org/obo/UBERON_0002539`
+#### Removed
+- [pharyngeal arch](http://purl.obolibrary.org/obo/UBERON_0002539) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-- [olfactory cortex layer 1](http://purl.obolibrary.org/obo/UBERON_0022317) SubClassOf [bounding layer of](http://purl.obolibrary.org/obo/RO_0002007) some [olfactory cortex](http://purl.obolibrary.org/obo/UBERON_0002894)
-### olfactory cortex layer 2 `http://purl.obolibrary.org/obo/UBERON_0022318`
+### pharyngeal membrane `http://purl.obolibrary.org/obo/UBERON_0009210`
+#### Removed
+- [pharyngeal membrane](http://purl.obolibrary.org/obo/UBERON_0009210) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-#### Added
-- [olfactory cortex layer 2](http://purl.obolibrary.org/obo/UBERON_0022318) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "uberon"
-- [olfactory cortex layer 2](http://purl.obolibrary.org/obo/UBERON_0022318) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "layer 2 of olfactory cortex"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "NLX:152610"
-- [olfactory cortex layer 2](http://purl.obolibrary.org/obo/UBERON_0022318) [id](http://www.geneontology.org/formats/oboInOwl#id) "UBERON:0022318"
+### phrenic nerve `http://purl.obolibrary.org/obo/UBERON_0001884`
+#### Removed
+- [phrenic nerve](http://purl.obolibrary.org/obo/UBERON_0001884) SubClassOf [neuron projection bundle](http://purl.obolibrary.org/obo/CARO_0001001)
-- [olfactory cortex layer 2](http://purl.obolibrary.org/obo/UBERON_0022318) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "NLX:152610"
-- [olfactory cortex layer 2](http://purl.obolibrary.org/obo/UBERON_0022318) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Middle layer of olfactory cortex lying deep to layer 1 and superficial to layer 3, characterized by a compact layer of cell bodies. It can be divided into a superficial part and a deep part."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "NLX:152610"
-- [olfactory cortex layer 2](http://purl.obolibrary.org/obo/UBERON_0022318) [label](http://www.w3.org/2000/01/rdf-schema#label) "olfactory cortex layer 2"
+### pilosebaceous unit `http://purl.obolibrary.org/obo/UBERON_0011932`
+#### Removed
+- [pilosebaceous unit](http://purl.obolibrary.org/obo/UBERON_0011932) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-- Class: [olfactory cortex layer 2](http://purl.obolibrary.org/obo/UBERON_0022318)
-- [olfactory cortex layer 2](http://purl.obolibrary.org/obo/UBERON_0022318) EquivalentTo [nervous system cell part layer](http://purl.obolibrary.org/obo/UBERON_0022303) and ([immediately deep to](http://purl.obolibrary.org/obo/BSPO_0001107) some [olfactory cortex layer 1](http://purl.obolibrary.org/obo/UBERON_0022317))
-- [olfactory cortex layer 2](http://purl.obolibrary.org/obo/UBERON_0022318) SubClassOf [composed primarily of](http://purl.obolibrary.org/obo/RO_0002473) some [neuronal cell body](http://purl.obolibrary.org/obo/GO_0043025)
+### pineal tract `http://purl.obolibrary.org/obo/UBERON_0034715`
+#### Removed
+- [pineal tract](http://purl.obolibrary.org/obo/UBERON_0034715) SubClassOf [neuron projection bundle](http://purl.obolibrary.org/obo/CARO_0001001)
-- [olfactory cortex layer 2](http://purl.obolibrary.org/obo/UBERON_0022318) SubClassOf [immediately deep to](http://purl.obolibrary.org/obo/BSPO_0001107) some [olfactory cortex layer 1](http://purl.obolibrary.org/obo/UBERON_0022317)
-- [olfactory cortex layer 2](http://purl.obolibrary.org/obo/UBERON_0022318) SubClassOf [central nervous system cell part cluster](http://purl.obolibrary.org/obo/UBERON_0011215)
-- [olfactory cortex layer 2](http://purl.obolibrary.org/obo/UBERON_0022318) SubClassOf [nervous system cell part layer](http://purl.obolibrary.org/obo/UBERON_0022303)
+### pinna `http://purl.obolibrary.org/obo/UBERON_0001757`
+#### Removed
+- [pinna](http://purl.obolibrary.org/obo/UBERON_0001757) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [olfactory cortex layer 2](http://purl.obolibrary.org/obo/UBERON_0022318) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [olfactory cortex](http://purl.obolibrary.org/obo/UBERON_0002894)
- - [source](http://www.geneontology.org/formats/oboInOwl#source) "nlx"
-### olfactory cortex layer 3 `http://purl.obolibrary.org/obo/UBERON_0035044`
+### placeholder removed `http://purl.obolibrary.org/obo/IAO_0000226`
#### Added
-- [olfactory cortex layer 3](http://purl.obolibrary.org/obo/UBERON_0035044) [label](http://www.w3.org/2000/01/rdf-schema#label) "olfactory cortex layer 3"
+- [placeholder removed](http://purl.obolibrary.org/obo/IAO_0000226) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "placeholder removed"@en
-- [olfactory cortex layer 3](http://purl.obolibrary.org/obo/UBERON_0035044) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Deepest layer of olfactory cortex."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "NLX:152611"
+- [placeholder removed](http://purl.obolibrary.org/obo/IAO_0000226) [label](http://www.w3.org/2000/01/rdf-schema#label) "placeholder removed"@en
-- [olfactory cortex layer 3](http://purl.obolibrary.org/obo/UBERON_0035044) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "uberon"
+- Individual: [placeholder removed](http://purl.obolibrary.org/obo/IAO_0000226)
-- [olfactory cortex layer 3](http://purl.obolibrary.org/obo/UBERON_0035044) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "NLX:152611"
-- [olfactory cortex layer 3](http://purl.obolibrary.org/obo/UBERON_0035044) [id](http://www.geneontology.org/formats/oboInOwl#id) "UBERON:0035044"
+### plantar nerve `http://purl.obolibrary.org/obo/UBERON_0035109`
+#### Removed
+- [plantar nerve](http://purl.obolibrary.org/obo/UBERON_0035109) SubClassOf [neuron projection bundle](http://purl.obolibrary.org/obo/CARO_0001001)
-- Class: [olfactory cortex layer 3](http://purl.obolibrary.org/obo/UBERON_0035044)
-- [olfactory cortex layer 3](http://purl.obolibrary.org/obo/UBERON_0035044) EquivalentTo [nervous system cell part layer](http://purl.obolibrary.org/obo/UBERON_0022303) and ([immediately deep to](http://purl.obolibrary.org/obo/BSPO_0001107) some [olfactory cortex layer 2](http://purl.obolibrary.org/obo/UBERON_0022318))
-- [olfactory cortex layer 3](http://purl.obolibrary.org/obo/UBERON_0035044) SubClassOf [overlaps](http://purl.obolibrary.org/obo/RO_0002131) some [piriform cortex layer 3](http://purl.obolibrary.org/obo/UBERON_0014283)
- - [source](http://www.geneontology.org/formats/oboInOwl#source) "NIFSTD"
+### plasma cell `http://purl.obolibrary.org/obo/CL_0000786`
+#### Removed
+- [plasma cell](http://purl.obolibrary.org/obo/CL_0000786) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-- [olfactory cortex layer 3](http://purl.obolibrary.org/obo/UBERON_0035044) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [olfactory cortex](http://purl.obolibrary.org/obo/UBERON_0002894)
- - [source](http://www.geneontology.org/formats/oboInOwl#source) "nlx"
-- [olfactory cortex layer 3](http://purl.obolibrary.org/obo/UBERON_0035044) SubClassOf [nervous system cell part layer](http://purl.obolibrary.org/obo/UBERON_0022303)
-- [olfactory cortex layer 3](http://purl.obolibrary.org/obo/UBERON_0035044) SubClassOf [immediately deep to](http://purl.obolibrary.org/obo/BSPO_0001107) some [olfactory cortex layer 2](http://purl.obolibrary.org/obo/UBERON_0022318)
+### platelet glycoprotein 4 `http://purl.obolibrary.org/obo/PR_000001905`
-- [olfactory cortex layer 3](http://purl.obolibrary.org/obo/UBERON_0035044) SubClassOf [central nervous system cell part cluster](http://purl.obolibrary.org/obo/UBERON_0011215)
+#### Added
+- [platelet glycoprotein 4](http://purl.obolibrary.org/obo/PR_000001905) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [platelet glycoprotein 4 (human)](http://purl.obolibrary.org/obo/PR_P16671)
-### olfactory tubercle `http://purl.obolibrary.org/obo/UBERON_0001883`
+### platelet glycoprotein Ib alpha chain `http://purl.obolibrary.org/obo/PR_000001907`
#### Added
-- [olfactory tubercle](http://purl.obolibrary.org/obo/UBERON_0001883) [id](http://www.geneontology.org/formats/oboInOwl#id) "UBERON:0001883"
+- [platelet glycoprotein Ib alpha chain](http://purl.obolibrary.org/obo/PR_000001907) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [platelet glycoprotein Ib alpha chain (human)](http://purl.obolibrary.org/obo/PR_P07359)
-- [olfactory tubercle](http://purl.obolibrary.org/obo/UBERON_0001883) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "MESH:D066208"
-- [olfactory tubercle](http://purl.obolibrary.org/obo/UBERON_0001883) [depicted by](http://xmlns.com/foaf/0.1/depicted_by) "http://upload.wikimedia.org/wikipedia/commons/4/4d/Gray732.png"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI)
+### pleura `http://purl.obolibrary.org/obo/UBERON_0000977`
+#### Removed
+- [pleura](http://purl.obolibrary.org/obo/UBERON_0000977) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-- [olfactory tubercle](http://purl.obolibrary.org/obo/UBERON_0001883) [RO_0002171](http://purl.obolibrary.org/obo/RO_0002171) [nucleus accumbens](http://purl.obolibrary.org/obo/UBERON_0001882)
- - [source](http://www.geneontology.org/formats/oboInOwl#source) "ABA"
-- [olfactory tubercle](http://purl.obolibrary.org/obo/UBERON_0001883) [label](http://www.w3.org/2000/01/rdf-schema#label) "olfactory tubercle"
-- [olfactory tubercle](http://purl.obolibrary.org/obo/UBERON_0001883) [UBPROP_0000008](http://purl.obolibrary.org/obo/UBPROP_0000008) "Absent in primates"
- - [source](http://www.geneontology.org/formats/oboInOwl#source) "MP"
+### pleural cavity `http://purl.obolibrary.org/obo/UBERON_0002402`
+#### Removed
+- [pleural cavity](http://purl.obolibrary.org/obo/UBERON_0002402) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [olfactory tubercle](http://purl.obolibrary.org/obo/UBERON_0001883) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "NLXANAT:1005037"
-- [olfactory tubercle](http://purl.obolibrary.org/obo/UBERON_0001883) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Region in the ventral telencephalon, prominent in rodents, but present in all mammals, consisting of a laminated cortical part and the cap/hilus region. It is traditionally viewed as part of the olfactory cortex but recognized by some as having a striatal character. According to many authors, the structure of the OT transitions from cortical like to striatal like along the lateral medial axis. (Maryann Martone)."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "NLXANAT:1005037"
-- [olfactory tubercle](http://purl.obolibrary.org/obo/UBERON_0001883) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "BTO:0001869"
+### pleuroperitoneal canal lumen `http://purl.obolibrary.org/obo/UBERON_0014704`
+#### Removed
+- [pleuroperitoneal canal lumen](http://purl.obolibrary.org/obo/UBERON_0014704) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [olfactory tubercle](http://purl.obolibrary.org/obo/UBERON_0001883) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "EV:0100177"
-- [olfactory tubercle](http://purl.obolibrary.org/obo/UBERON_0001883) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [uberon_slim](http://purl.obolibrary.org/obo/uberon/core#uberon_slim)
-- [olfactory tubercle](http://purl.obolibrary.org/obo/UBERON_0001883) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "tuberculum olfactorium"
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [LATIN](http://purl.obolibrary.org/obo/uberon/core#LATIN)
+### polychromatophilic erythroblast `http://purl.obolibrary.org/obo/CL_0000550`
+#### Removed
+- [polychromatophilic erythroblast](http://purl.obolibrary.org/obo/CL_0000550) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-- [olfactory tubercle](http://purl.obolibrary.org/obo/UBERON_0001883) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "BAMS:OT"
-- [olfactory tubercle](http://purl.obolibrary.org/obo/UBERON_0001883) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Wikipedia:Olfactory_tubercle"
-- [olfactory tubercle](http://purl.obolibrary.org/obo/UBERON_0001883) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "BAMS:OLT"
+### pontine tegmentum `http://purl.obolibrary.org/obo/UBERON_0003023`
+#### Removed
+- [pontine tegmentum](http://purl.obolibrary.org/obo/UBERON_0003023) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [olfactory tubercle](http://purl.obolibrary.org/obo/UBERON_0001883) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "BM:Tel-OLT"
-- [olfactory tubercle](http://purl.obolibrary.org/obo/UBERON_0001883) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "BAMS:Tu"
-- [olfactory tubercle](http://purl.obolibrary.org/obo/UBERON_0001883) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "BAMS:DLT"
+### portal triad `http://purl.obolibrary.org/obo/UBERON_0001279`
+#### Removed
+- [portal triad](http://purl.obolibrary.org/obo/UBERON_0001279) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [olfactory tubercle](http://purl.obolibrary.org/obo/UBERON_0001883) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "VHOG:0001625"
-- [olfactory tubercle](http://purl.obolibrary.org/obo/UBERON_0001883) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "EHDAA2:0004701"
-- [olfactory tubercle](http://purl.obolibrary.org/obo/UBERON_0001883) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "uberon"
+### positively correlated with `http://purl.obolibrary.org/obo/RO_0017003`
-- [olfactory tubercle](http://purl.obolibrary.org/obo/UBERON_0001883) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "MBA:754"
+#### Added
+- [positively correlated with](http://purl.obolibrary.org/obo/RO_0017003) [contributor](http://purl.org/dc/terms/contributor) [0000-0003-1909-9269](https://orcid.org/0000-0003-1909-9269)
-- [olfactory tubercle](http://purl.obolibrary.org/obo/UBERON_0001883) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "HBA:10145"
+- [positively correlated with](http://purl.obolibrary.org/obo/RO_0017003) [IAO_0000118](http://purl.obolibrary.org/obo/IAO_0000118) "directly correlated with"@en
-- [olfactory tubercle](http://purl.obolibrary.org/obo/UBERON_0001883) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [pheno_slim](http://purl.obolibrary.org/obo/uberon/core#pheno_slim)
+- [positively correlated with](http://purl.obolibrary.org/obo/RO_0017003) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A relation between entities in which one increases or decreases as the other does the same."@en
-- [olfactory tubercle](http://purl.obolibrary.org/obo/UBERON_0001883) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "MA:0000976"
+- [positively correlated with](http://purl.obolibrary.org/obo/RO_0017003) [label](http://www.w3.org/2000/01/rdf-schema#label) "positively correlated with"@en
-- [olfactory tubercle](http://purl.obolibrary.org/obo/UBERON_0001883) [RO_0002174](http://purl.obolibrary.org/obo/RO_0002174) [Primates](http://purl.obolibrary.org/obo/NCBITaxon_9443)
- - [editor_note](http://www.geneontology.org/formats/oboInOwl#editor_note) "check EHDAA2"
+- ObjectProperty: [positively correlated with](http://purl.obolibrary.org/obo/RO_0017003)
- - [source](http://www.geneontology.org/formats/oboInOwl#source) "MP"
+- Reflexive: [positively correlated with](http://purl.obolibrary.org/obo/RO_0017003)
-- [olfactory tubercle](http://purl.obolibrary.org/obo/UBERON_0001883) [UBPROP_0000001](http://purl.obolibrary.org/obo/UBPROP_0000001) "The olfactory tubercle is a structure involved in Olfaction. It is present in humans, but much smaller than it is in some other animals. It is a frequent subject of research."
- - [source](http://www.geneontology.org/formats/oboInOwl#source) "Wikipedia:Olfactory_tubercle"
+- [positively correlated with](http://purl.obolibrary.org/obo/RO_0017003) SubPropertyOf: [correlated with](http://purl.obolibrary.org/obo/RO_0002610)
-- [olfactory tubercle](http://purl.obolibrary.org/obo/UBERON_0001883) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "DHBA:10310"
+- Symmetric: [positively correlated with](http://purl.obolibrary.org/obo/RO_0017003)
-- [olfactory tubercle](http://purl.obolibrary.org/obo/UBERON_0001883) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "EMAPA:35616"
-- [olfactory tubercle](http://purl.obolibrary.org/obo/UBERON_0001883) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PBA:10096"
+### post-anal tail `http://purl.obolibrary.org/obo/UBERON_0007812`
+#### Removed
+- [post-anal tail](http://purl.obolibrary.org/obo/UBERON_0007812) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- Class: [olfactory tubercle](http://purl.obolibrary.org/obo/UBERON_0001883)
-- [olfactory tubercle](http://purl.obolibrary.org/obo/UBERON_0001883) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [olfactory cortex](http://purl.obolibrary.org/obo/UBERON_0002894)
- - [source](http://www.geneontology.org/formats/oboInOwl#source) "MA"
- - [source](http://www.geneontology.org/formats/oboInOwl#source) "VHOG"
+### postcranial axial skeletal system `http://purl.obolibrary.org/obo/UBERON_0011138`
+#### Removed
+- [postcranial axial skeletal system](http://purl.obolibrary.org/obo/UBERON_0011138) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
- - [source](http://www.geneontology.org/formats/oboInOwl#source) "Wikipedia"
- - [source](http://www.geneontology.org/formats/oboInOwl#source) "EHDAA2-inferred"
-- [olfactory tubercle](http://purl.obolibrary.org/obo/UBERON_0001883) SubClassOf [telencephalic nucleus](http://purl.obolibrary.org/obo/UBERON_0009663)
+### postcranial axial skeleton `http://purl.obolibrary.org/obo/UBERON_0002090`
+#### Removed
+- [postcranial axial skeleton](http://purl.obolibrary.org/obo/UBERON_0002090) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [olfactory tubercle](http://purl.obolibrary.org/obo/UBERON_0001883) SubClassOf [contributes to morphology of](http://purl.obolibrary.org/obo/RO_0002433) some [olfactory cortex](http://purl.obolibrary.org/obo/UBERON_0002894)
-### ovulation cycle process `http://purl.obolibrary.org/obo/GO_0022602`
+### posterior neural tube `http://purl.obolibrary.org/obo/UBERON_0003076`
#### Removed
-- [ovulation cycle process](http://purl.obolibrary.org/obo/GO_0022602) EquivalentTo [biological_process](http://purl.obolibrary.org/obo/GO_0008150) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [ovulation cycle](http://purl.obolibrary.org/obo/GO_0042698))
+- [posterior neural tube](http://purl.obolibrary.org/obo/UBERON_0003076) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-### pair of lungs `http://purl.obolibrary.org/obo/UBERON_0000170`
+### pre-conventional dendritic cell `http://purl.obolibrary.org/obo/CL_0002010`
#### Removed
-- [pair of lungs](http://purl.obolibrary.org/obo/UBERON_0000170) [present_in_taxon](http://purl.obolibrary.org/obo/RO_0002175) [Homo sapiens](http://purl.obolibrary.org/obo/NCBITaxon_9606)
+- [pre-conventional dendritic cell](http://purl.obolibrary.org/obo/CL_0002010) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-- [pair of lungs](http://purl.obolibrary.org/obo/UBERON_0000170) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [human_reference_atlas](http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas)
-
-### peptidase activity `http://purl.obolibrary.org/obo/GO_0008233`
+### pre-natural killer cell `http://purl.obolibrary.org/obo/CL_0000937`
#### Removed
-- [peptidase activity](http://purl.obolibrary.org/obo/GO_0008233) [has_alternative_id](http://www.geneontology.org/formats/oboInOwl#hasAlternativeId) "GO:0070011"
-
-- [peptidase activity](http://purl.obolibrary.org/obo/GO_0008233) [has_alternative_id](http://www.geneontology.org/formats/oboInOwl#hasAlternativeId) "GO:0070010"
+- [pre-natural killer cell](http://purl.obolibrary.org/obo/CL_0000937) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-- [peptidase activity](http://purl.obolibrary.org/obo/GO_0008233) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "molecular_function"
-- [peptidase activity](http://purl.obolibrary.org/obo/GO_0008233) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "proteinase activity"
-- [peptidase activity](http://purl.obolibrary.org/obo/GO_0008233) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "protease activity"
-
-- [peptidase activity](http://purl.obolibrary.org/obo/GO_0008233) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-3065959"
- - [label](http://www.w3.org/2000/01/rdf-schema#label) "An unknown protease degrades hCBXs"
+### preameloblast `http://purl.obolibrary.org/obo/CL_0007000`
+#### Removed
+- [preameloblast](http://purl.obolibrary.org/obo/CL_0007000) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [peptidase activity](http://purl.obolibrary.org/obo/GO_0008233) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "peptidase activity, acting on D-amino acid peptides"
-- [peptidase activity](http://purl.obolibrary.org/obo/GO_0008233) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0008233"
-- [peptidase activity](http://purl.obolibrary.org/obo/GO_0008233) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "peptidase activity, acting on L-amino acid peptides"
+### prechordal mesoderm `http://purl.obolibrary.org/obo/UBERON_0034878`
+#### Removed
+- [prechordal mesoderm](http://purl.obolibrary.org/obo/UBERON_0034878) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [peptidase activity](http://purl.obolibrary.org/obo/GO_0008233) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "peptide hydrolase activity"
-- [peptidase activity](http://purl.obolibrary.org/obo/GO_0008233) [label](http://www.w3.org/2000/01/rdf-schema#label) "peptidase activity"
-- [peptidase activity](http://purl.obolibrary.org/obo/GO_0008233) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-376149"
- - [label](http://www.w3.org/2000/01/rdf-schema#label) "Proteolytic processing of SLIT"
+### prechordal plate `http://purl.obolibrary.org/obo/UBERON_0003063`
+#### Removed
+- [prechordal plate](http://purl.obolibrary.org/obo/UBERON_0003063) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [peptidase activity](http://purl.obolibrary.org/obo/GO_0008233) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [goslim_candida](http://purl.obolibrary.org/obo/go#goslim_candida)
-- [peptidase activity](http://purl.obolibrary.org/obo/GO_0008233) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [goslim_metagenomics](http://purl.obolibrary.org/obo/go#goslim_metagenomics)
-- [peptidase activity](http://purl.obolibrary.org/obo/GO_0008233) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-3065958"
- - [label](http://www.w3.org/2000/01/rdf-schema#label) "An unknown protease degrades ACACA"
+### preferred_root `http://purl.obolibrary.org/obo/IAO_0000700`
-- [peptidase activity](http://purl.obolibrary.org/obo/GO_0008233) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [goslim_yeast](http://purl.obolibrary.org/obo/go#goslim_yeast)
+#### Added
+- [preferred_root](http://purl.obolibrary.org/obo/IAO_0000700) [label](http://www.w3.org/2000/01/rdf-schema#label) "has ontology root term"@en
-- [peptidase activity](http://purl.obolibrary.org/obo/GO_0008233) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-205112"
- - [label](http://www.w3.org/2000/01/rdf-schema#label) "gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6"
+- [preferred_root](http://purl.obolibrary.org/obo/IAO_0000700) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "has ontology root term"@en
-- [peptidase activity](http://purl.obolibrary.org/obo/GO_0008233) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [goslim_chembl](http://purl.obolibrary.org/obo/go#goslim_chembl)
+- [preferred_root](http://purl.obolibrary.org/obo/IAO_0000700) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Ontology annotation property. Relates an ontology to a term that is a designated root term of the ontology. Display tools like OLS can use terms annotated with this property as the starting point for rendering the ontology class hierarchy. There can be more than one root."@en
-- [peptidase activity](http://purl.obolibrary.org/obo/GO_0008233) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [goslim_drosophila](http://purl.obolibrary.org/obo/go#goslim_drosophila)
+- [preferred_root](http://purl.obolibrary.org/obo/IAO_0000700) [IAO_0000117](http://purl.obolibrary.org/obo/IAO_0000117) "Nicolas Matentzoglu"@en
-- [peptidase activity](http://purl.obolibrary.org/obo/GO_0008233) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "hydrolase, acting on peptide bonds"
-- [peptidase activity](http://purl.obolibrary.org/obo/GO_0008233) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-3000243"
- - [label](http://www.w3.org/2000/01/rdf-schema#label) "Unknown lysosomal protease degrades CBLIF:RCbl to release Cbl"
+### premigratory neural crest cell `http://purl.obolibrary.org/obo/CL_0007004`
+#### Removed
+- [premigratory neural crest cell](http://purl.obolibrary.org/obo/CL_0007004) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [peptidase activity](http://purl.obolibrary.org/obo/GO_0008233) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [goslim_pir](http://purl.obolibrary.org/obo/go#goslim_pir)
-- [peptidase activity](http://purl.obolibrary.org/obo/GO_0008233) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-3139027"
- - [label](http://www.w3.org/2000/01/rdf-schema#label) "Maturation of HIV Virion"
-- [peptidase activity](http://purl.obolibrary.org/obo/GO_0008233) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-3000263"
- - [label](http://www.w3.org/2000/01/rdf-schema#label) "TCN2:RCbl is degraded to release RCbl"
+### presumptive rhombomere 1 `http://purl.obolibrary.org/obo/UBERON_0007289`
-- [peptidase activity](http://purl.obolibrary.org/obo/GO_0008233) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-5684864"
- - [label](http://www.w3.org/2000/01/rdf-schema#label) "NAPSA, CTSH, PGA3-5 cleave pro-SFTPB"
+#### Added
+- [presumptive rhombomere 1](http://purl.obolibrary.org/obo/UBERON_0007289) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ZFA:0001207"
-- [peptidase activity](http://purl.obolibrary.org/obo/GO_0008233) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-5685902"
- - [label](http://www.w3.org/2000/01/rdf-schema#label) "NAPSA, CTSH, PGA3-5 cleave pro-SFTPC"
+- [presumptive rhombomere 1](http://purl.obolibrary.org/obo/UBERON_0007289) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "TAO:0001207"
-- [peptidase activity](http://purl.obolibrary.org/obo/GO_0008233) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-448678"
- - [label](http://www.w3.org/2000/01/rdf-schema#label) "CTSG cleaves CASP1(1-404)"
+- [presumptive rhombomere 1](http://purl.obolibrary.org/obo/UBERON_0007289) [label](http://www.w3.org/2000/01/rdf-schema#label) "presumptive rhombomere 1"
-- [peptidase activity](http://purl.obolibrary.org/obo/GO_0008233) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-4167501"
- - [label](http://www.w3.org/2000/01/rdf-schema#label) "An unknown protease degrades ACACB"
+- [presumptive rhombomere 1](http://purl.obolibrary.org/obo/UBERON_0007289) [id](http://www.geneontology.org/formats/oboInOwl#id) "UBERON:0007289"
-- [peptidase activity](http://purl.obolibrary.org/obo/GO_0008233) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-6803060"
- - [label](http://www.w3.org/2000/01/rdf-schema#label) "DCD(63-110) is processed to DCD(63-109)"
+- [presumptive rhombomere 1](http://purl.obolibrary.org/obo/UBERON_0007289) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "uberon"
-- [peptidase activity](http://purl.obolibrary.org/obo/GO_0008233) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-5655483"
- - [label](http://www.w3.org/2000/01/rdf-schema#label) "USP1 autocleavage"
+- [presumptive rhombomere 1](http://purl.obolibrary.org/obo/UBERON_0007289) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A presumptive structure that has the potential to develop into a rhombomere 1."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "OBOL:automatic"
-- [peptidase activity](http://purl.obolibrary.org/obo/GO_0008233) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "EC:3.4.-.-"
+- Class: [presumptive rhombomere 1](http://purl.obolibrary.org/obo/UBERON_0007289)
-- [peptidase activity](http://purl.obolibrary.org/obo/GO_0008233) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:jl"
+- [presumptive rhombomere 1](http://purl.obolibrary.org/obo/UBERON_0007289) EquivalentTo [presumptive structure](http://purl.obolibrary.org/obo/UBERON_0006598) and ([has potential to develop into](http://purl.obolibrary.org/obo/RO_0002387) some [rhombomere 1](http://purl.obolibrary.org/obo/UBERON_0005499))
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ISBN:0815332181"
+- [presumptive rhombomere 1](http://purl.obolibrary.org/obo/UBERON_0007289) SubClassOf [has potential to develop into](http://purl.obolibrary.org/obo/RO_0002387) some [rhombomere 1](http://purl.obolibrary.org/obo/UBERON_0005499)
-- Class: [peptidase activity](http://purl.obolibrary.org/obo/GO_0008233)
+- [presumptive rhombomere 1](http://purl.obolibrary.org/obo/UBERON_0007289) SubClassOf [presumptive structure](http://purl.obolibrary.org/obo/UBERON_0006598)
-- [peptidase activity](http://purl.obolibrary.org/obo/GO_0008233) SubClassOf [hydrolase activity](http://purl.obolibrary.org/obo/GO_0016787)
-- [peptidase activity](http://purl.obolibrary.org/obo/GO_0008233) SubClassOf [catalytic activity, acting on a protein](http://purl.obolibrary.org/obo/GO_0140096)
+### presumptive structure `http://purl.obolibrary.org/obo/UBERON_0006598`
+#### Removed
+- [presumptive structure](http://purl.obolibrary.org/obo/UBERON_0006598) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-### peptidase complex `http://purl.obolibrary.org/obo/GO_1905368`
+### primary interneuron `http://purl.obolibrary.org/obo/CL_0000534`
#### Removed
-- [peptidase complex](http://purl.obolibrary.org/obo/GO_1905368) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:1905368"
+- [primary interneuron](http://purl.obolibrary.org/obo/CL_0000534) [label](http://www.w3.org/2000/01/rdf-schema#label) "primary interneuron"
-- [peptidase complex](http://purl.obolibrary.org/obo/GO_1905368) [label](http://www.w3.org/2000/01/rdf-schema#label) "peptidase complex"
+#### Added
+- [primary interneuron](http://purl.obolibrary.org/obo/CL_0000534) [label](http://www.w3.org/2000/01/rdf-schema#label) "primary interneuron (sensu Teleostei)"
-- [peptidase complex](http://purl.obolibrary.org/obo/GO_1905368) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "protease complex"
+- [primary interneuron](http://purl.obolibrary.org/obo/CL_0000534) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A primary neuron (sensu Teleostei) that is neither a sensory neuron or a motor neuron."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:1842357"
-- [peptidase complex](http://purl.obolibrary.org/obo/GO_1905368) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "An example of this is PLAU in human (UniProt symbol P00749) in PMID:1689240 (inferred from direct assay)."
-- [peptidase complex](http://purl.obolibrary.org/obo/GO_1905368) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "cellular_component"
+### primary lens fiber `http://purl.obolibrary.org/obo/CL_0002228`
+#### Removed
+- [primary lens fiber](http://purl.obolibrary.org/obo/CL_0002228) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [peptidase complex](http://purl.obolibrary.org/obo/GO_1905368) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "tryptase complex"
-- [peptidase complex](http://purl.obolibrary.org/obo/GO_1905368) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A protein complex which is capable of peptidase activity."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:bhm"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie"
+### primary motor neuron `http://purl.obolibrary.org/obo/CL_0000533`
+#### Removed
+- [primary motor neuron](http://purl.obolibrary.org/obo/CL_0000533) [label](http://www.w3.org/2000/01/rdf-schema#label) "primary motor neuron"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GO_REF:0000088"
+- [primary motor neuron](http://purl.obolibrary.org/obo/CL_0000533) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "FMA:83619"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:1689240"
+#### Added
+- [primary motor neuron](http://purl.obolibrary.org/obo/CL_0000533) [label](http://www.w3.org/2000/01/rdf-schema#label) "primary motor neuron (sensu Teleostei)"
-- [peptidase complex](http://purl.obolibrary.org/obo/GO_1905368) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "bhm"
+- [primary motor neuron](http://purl.obolibrary.org/obo/CL_0000533) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A primary neuron (sensu Teleostei) that has a motor function."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:1842357"
-- [peptidase complex](http://purl.obolibrary.org/obo/GO_1905368) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2016-08-16T12:49:36Z"
-- Class: [peptidase complex](http://purl.obolibrary.org/obo/GO_1905368)
+### primary neuron `http://purl.obolibrary.org/obo/CL_0000530`
+#### Removed
+- [primary neuron](http://purl.obolibrary.org/obo/CL_0000530) [label](http://www.w3.org/2000/01/rdf-schema#label) "primary neuron"
-- [peptidase complex](http://purl.obolibrary.org/obo/GO_1905368) EquivalentTo [protein-containing complex](http://purl.obolibrary.org/obo/GO_0032991) and ([capable of](http://purl.obolibrary.org/obo/RO_0002215) some [peptidase activity](http://purl.obolibrary.org/obo/GO_0008233))
+#### Added
+- [primary neuron](http://purl.obolibrary.org/obo/CL_0000530) [label](http://www.w3.org/2000/01/rdf-schema#label) "primary neuron (sensu Teleostei)"
-- [peptidase complex](http://purl.obolibrary.org/obo/GO_1905368) SubClassOf [capable of](http://purl.obolibrary.org/obo/RO_0002215) some [peptidase activity](http://purl.obolibrary.org/obo/GO_0008233)
+- [primary neuron](http://purl.obolibrary.org/obo/CL_0000530) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A neuron that develops during the early segmentation stages in teleosts, before the neural tube is formed."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:1842357"
-- [peptidase complex](http://purl.obolibrary.org/obo/GO_1905368) SubClassOf [catalytic complex](http://purl.obolibrary.org/obo/GO_1902494)
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1242/dev.108.1.121"
+- [primary neuron](http://purl.obolibrary.org/obo/CL_0000530) SubClassOf [only in taxon](http://purl.obolibrary.org/obo/RO_0002160) some [Teleostei](http://purl.obolibrary.org/obo/NCBITaxon_32443)
+ - [term tracker item](http://purl.obolibrary.org/obo/IAO_0000233) "https://github.com/obophenotype/cell-ontology/pull/1950"
-### peptidyl-amino acid modification `http://purl.obolibrary.org/obo/GO_0018193`
+### primary nodular lymphoid tissue `http://purl.obolibrary.org/obo/UBERON_0010422`
#### Removed
-- [peptidyl-amino acid modification](http://purl.obolibrary.org/obo/GO_0018193) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [term_scheduled_for_obsoletion](http://purl.obolibrary.org/obo/go#term_scheduled_for_obsoletion)
+- [primary nodular lymphoid tissue](http://purl.obolibrary.org/obo/UBERON_0010422) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-#### Added
-- [peptidyl-amino acid modification](http://purl.obolibrary.org/obo/GO_0018193) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate)
-### peptidyl-tyrosine modification `http://purl.obolibrary.org/obo/GO_0018212`
+### primary oocyte `http://purl.obolibrary.org/obo/CL_0000654`
#### Removed
-- [peptidyl-tyrosine modification](http://purl.obolibrary.org/obo/GO_0018212) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [term_scheduled_for_obsoletion](http://purl.obolibrary.org/obo/go#term_scheduled_for_obsoletion)
+- [primary oocyte](http://purl.obolibrary.org/obo/CL_0000654) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-#### Added
-- [peptidyl-tyrosine modification](http://purl.obolibrary.org/obo/GO_0018212) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate)
-### peptidyl-tyrosine phosphorylation `http://purl.obolibrary.org/obo/GO_0018108`
+### primary sensory neuron `http://purl.obolibrary.org/obo/CL_0000531`
#### Removed
-- [peptidyl-tyrosine phosphorylation](http://purl.obolibrary.org/obo/GO_0018108) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [term_scheduled_for_obsoletion](http://purl.obolibrary.org/obo/go#term_scheduled_for_obsoletion)
+- [primary sensory neuron](http://purl.obolibrary.org/obo/CL_0000531) [label](http://www.w3.org/2000/01/rdf-schema#label) "primary sensory neuron"
#### Added
-- [peptidyl-tyrosine phosphorylation](http://purl.obolibrary.org/obo/GO_0018108) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate)
+- [primary sensory neuron](http://purl.obolibrary.org/obo/CL_0000531) [label](http://www.w3.org/2000/01/rdf-schema#label) "primary sensory neuron (sensu Teleostei)"
+- [primary sensory neuron](http://purl.obolibrary.org/obo/CL_0000531) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A primary neuron (sensu Teleostei) that has a sensory function."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:1842357"
-### peripheral nervous system myelin formation `http://purl.obolibrary.org/obo/GO_0032290`
-
-#### Added
-- [peripheral nervous system myelin formation](http://purl.obolibrary.org/obo/GO_0032290) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "peripheral nervous system myelin sheath formation"
+### primitive erythroid progenitor `http://purl.obolibrary.org/obo/CL_0002361`
+#### Removed
+- [primitive erythroid progenitor](http://purl.obolibrary.org/obo/CL_0002361) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-### piriform cortex `http://purl.obolibrary.org/obo/UBERON_0004725`
-#### Added
-- [piriform cortex](http://purl.obolibrary.org/obo/UBERON_0004725) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "MA:0000978"
-- [piriform cortex](http://purl.obolibrary.org/obo/UBERON_0004725) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "neuronames:165"
- - [source](http://www.geneontology.org/formats/oboInOwl#source) "BIRNLEX:1097"
+### primitive nephron `http://purl.obolibrary.org/obo/UBERON_0010532`
+#### Removed
+- [primitive nephron](http://purl.obolibrary.org/obo/UBERON_0010532) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [piriform cortex](http://purl.obolibrary.org/obo/UBERON_0004725) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "BIRNLEX:1097"
-- [piriform cortex](http://purl.obolibrary.org/obo/UBERON_0004725) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "MESH:D066195"
-- [piriform cortex](http://purl.obolibrary.org/obo/UBERON_0004725) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "uberon"
+### primitive streak `http://purl.obolibrary.org/obo/UBERON_0004341`
+#### Removed
+- [primitive streak](http://purl.obolibrary.org/obo/UBERON_0004341) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [piriform cortex](http://purl.obolibrary.org/obo/UBERON_0004725) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "regio praepiriformis"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "NeuroNames:165"
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [LATIN](http://purl.obolibrary.org/obo/uberon/core#LATIN)
-- [piriform cortex](http://purl.obolibrary.org/obo/UBERON_0004725) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "pyriform cortex"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Wikipedia:Piriform_cortex"
+### primitive urogenital sinus `http://purl.obolibrary.org/obo/UBERON_0000164`
+#### Removed
+- [primitive urogenital sinus](http://purl.obolibrary.org/obo/UBERON_0000164) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [piriform cortex](http://purl.obolibrary.org/obo/UBERON_0004725) [label](http://www.w3.org/2000/01/rdf-schema#label) "piriform cortex"
-- [piriform cortex](http://purl.obolibrary.org/obo/UBERON_0004725) [depicted by](http://xmlns.com/foaf/0.1/depicted_by) "http://upload.wikimedia.org/wikipedia/commons/b/b1/Human_brainstem_anterior_view_2_description.JPG"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI)
-- [piriform cortex](http://purl.obolibrary.org/obo/UBERON_0004725) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [human_reference_atlas](http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas)
+### primordial vasculature `http://purl.obolibrary.org/obo/UBERON_0014903`
+#### Removed
+- [primordial vasculature](http://purl.obolibrary.org/obo/UBERON_0014903) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [piriform cortex](http://purl.obolibrary.org/obo/UBERON_0004725) [UBPROP_0000008](http://purl.obolibrary.org/obo/UBPROP_0000008) "Piriform cortical regions are present in the brains of amphibians, reptiles and mammals. The piriform cortex is among three areas that emerge in the telencephalon of amphibians, situated caudally to a dorsal area, which is caudal to a hippocampal area. Farther along the phylogenic timeline, the telencephalic bulb of reptiles as viewed in a cross section of the transverse plane extends with the archipallial hippocampus folding toward the midline and down as the dorsal area begins to form a recognizable cortex. As mammalian cerebrums developed, volume of the dorsal cortex increased in slightly greater proportion, as compared proportionally with increased overall brain volume, until it enveloped the hippocampal regions. Recognized as neopallium or neocortex, enlarged dorsal areas envelop the paleopallial piriform cortex in humans and Old World monkeys. Among taxonomic groupings of mammals, the piriform cortex and the olfactory bulb become proportionally smaller in the brains of phylogenically younger species. The piriform cortex occupies a greater proportion of the overall brain and of the telencephalic brains of insectivores than in primates. The piriform cortex continues to occupy a consistent albeit small and declining proportion of the increasingly large telencephalon in the most recent primate species while the volume of the olfactory bulb becomes less in proportion"
- - [source](http://www.geneontology.org/formats/oboInOwl#source) "WP"
-- [piriform cortex](http://purl.obolibrary.org/obo/UBERON_0004725) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "EV:0100178"
-- [piriform cortex](http://purl.obolibrary.org/obo/UBERON_0004725) [id](http://www.geneontology.org/formats/oboInOwl#id) "UBERON:0004725"
+### pro-NK cell `http://purl.obolibrary.org/obo/CL_0000825`
+#### Removed
+- [pro-NK cell](http://purl.obolibrary.org/obo/CL_0000825) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-- [piriform cortex](http://purl.obolibrary.org/obo/UBERON_0004725) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "primary olfactory cortex"
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [INCONSISTENT](http://purl.obolibrary.org/obo/uberon/core#INCONSISTENT)
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Wikipedia:Piriform_cortex"
-- [piriform cortex](http://purl.obolibrary.org/obo/UBERON_0004725) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [pheno_slim](http://purl.obolibrary.org/obo/uberon/core#pheno_slim)
+### process `http://purl.obolibrary.org/obo/BFO_0000015`
+#### Removed
+- [process](http://purl.obolibrary.org/obo/BFO_0000015) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "An occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t."@en
-- [piriform cortex](http://purl.obolibrary.org/obo/UBERON_0004725) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "BAMS:PIR"
+#### Added
+- [process](http://purl.obolibrary.org/obo/BFO_0000015) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "An occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t."@en
-- [piriform cortex](http://purl.obolibrary.org/obo/UBERON_0004725) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "BAMS:Pir"
+- [process](http://purl.obolibrary.org/obo/BFO_0000015) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "p is a process = Def. p is an occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t. (axiom label in BFO2 Reference: [083-003])"@en
-- [piriform cortex](http://purl.obolibrary.org/obo/UBERON_0004725) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "cortex piriformis"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Wikipedia:Piriform_cortex"
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [LATIN](http://purl.obolibrary.org/obo/uberon/core#LATIN)
+### proctodeum `http://purl.obolibrary.org/obo/UBERON_0000931`
+#### Removed
+- [proctodeum](http://purl.obolibrary.org/obo/UBERON_0000931) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [piriform cortex](http://purl.obolibrary.org/obo/UBERON_0004725) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "eupalaeocortex"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "NeuroNames:165"
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [LATIN](http://purl.obolibrary.org/obo/uberon/core#LATIN)
-- [piriform cortex](http://purl.obolibrary.org/obo/UBERON_0004725) [present_in_taxon](http://purl.obolibrary.org/obo/RO_0002175) [Homo sapiens](http://purl.obolibrary.org/obo/NCBITaxon_9606)
+### proenkephalin-B `http://purl.obolibrary.org/obo/PR_000012526`
-- [piriform cortex](http://purl.obolibrary.org/obo/UBERON_0004725) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "pyriform lobe"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Wikipedia:Piriform_cortex"
+#### Added
+- [proenkephalin-B](http://purl.obolibrary.org/obo/PR_000012526) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [proenkephalin-B (human)](http://purl.obolibrary.org/obo/PR_P01213)
-- [piriform cortex](http://purl.obolibrary.org/obo/UBERON_0004725) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "piriform area"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "MA:0000978"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "BTO:0002651"
+### proerythroblast `http://purl.obolibrary.org/obo/CL_0000547`
+#### Removed
+- [proerythroblast](http://purl.obolibrary.org/obo/CL_0000547) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-- [piriform cortex](http://purl.obolibrary.org/obo/UBERON_0004725) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "paleopallium"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Wikipedia:Piriform_cortex"
-- [piriform cortex](http://purl.obolibrary.org/obo/UBERON_0004725) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "primary olfactory areas"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "BIRNLEX:2706"
-- [piriform cortex](http://purl.obolibrary.org/obo/UBERON_0004725) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "UMLS:C0228280"
- - [source](http://www.geneontology.org/formats/oboInOwl#source) "BIRNLEX:1097"
+### progenitor cell `http://purl.obolibrary.org/obo/CL_0011026`
+#### Removed
+- [progenitor cell](http://purl.obolibrary.org/obo/CL_0011026) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [piriform cortex](http://purl.obolibrary.org/obo/UBERON_0004725) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The subdivision of the laminated olfactory cortex with only three main layers that receive monosynaptic input from the olfactory bulb via the lateral olfactory tract; it is located bilaterally in the ventrolateral forebrain and is commonly divided into anterior and posterior regions."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "MP:0010009"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:17714095"
-- [piriform cortex](http://purl.obolibrary.org/obo/UBERON_0004725) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "palaeocortex II"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "NeuroNames:165"
+### programmed cell death protein 1 `http://purl.obolibrary.org/obo/PR_000001919`
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [LATIN](http://purl.obolibrary.org/obo/uberon/core#LATIN)
+#### Added
+- [programmed cell death protein 1](http://purl.obolibrary.org/obo/PR_000001919) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [programmed cell death protein 1 (human)](http://purl.obolibrary.org/obo/PR_Q15116)
-- [piriform cortex](http://purl.obolibrary.org/obo/UBERON_0004725) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "piriform lobe"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "BTO:0002651"
-- [piriform cortex](http://purl.obolibrary.org/obo/UBERON_0004725) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "DHBA:10311"
+### prolactin `http://purl.obolibrary.org/obo/PR_000013246`
-- [piriform cortex](http://purl.obolibrary.org/obo/UBERON_0004725) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "HBA:10142"
+#### Added
+- [prolactin](http://purl.obolibrary.org/obo/PR_000013246) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [prolactin (human)](http://purl.obolibrary.org/obo/PR_P01236)
-- [piriform cortex](http://purl.obolibrary.org/obo/UBERON_0004725) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Wikipedia:Piriform_cortex"
-- [piriform cortex](http://purl.obolibrary.org/obo/UBERON_0004725) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "olfactory pallium"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ISBN:0471888893"
+### prominin-1 `http://purl.obolibrary.org/obo/PR_000001786`
-- [piriform cortex](http://purl.obolibrary.org/obo/UBERON_0004725) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "SCTID:369098004"
+#### Added
+- [prominin-1](http://purl.obolibrary.org/obo/PR_000001786) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [prominin-1 (human)](http://purl.obolibrary.org/obo/PR_O43490)
-- [piriform cortex](http://purl.obolibrary.org/obo/UBERON_0004725) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "area prepiriformis"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "NeuroNames:165"
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [LATIN](http://purl.obolibrary.org/obo/uberon/core#LATIN)
+### promonocyte `http://purl.obolibrary.org/obo/CL_0000559`
+#### Removed
+- [promonocyte](http://purl.obolibrary.org/obo/CL_0000559) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-- [piriform cortex](http://purl.obolibrary.org/obo/UBERON_0004725) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "EMAPA:32767"
-- [piriform cortex](http://purl.obolibrary.org/obo/UBERON_0004725) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "BTO:0002651"
-- Class: [piriform cortex](http://purl.obolibrary.org/obo/UBERON_0004725)
+### promyelocyte `http://purl.obolibrary.org/obo/CL_0000836`
+#### Removed
+- [promyelocyte](http://purl.obolibrary.org/obo/CL_0000836) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-- [piriform cortex](http://purl.obolibrary.org/obo/UBERON_0004725) SubClassOf [contributes to morphology of](http://purl.obolibrary.org/obo/RO_0002433) some [olfactory cortex](http://purl.obolibrary.org/obo/UBERON_0002894)
-- [piriform cortex](http://purl.obolibrary.org/obo/UBERON_0004725) SubClassOf [only in taxon](http://purl.obolibrary.org/obo/RO_0002160) some [Tetrapoda](http://purl.obolibrary.org/obo/NCBITaxon_32523)
- - [source](http://www.geneontology.org/formats/oboInOwl#source) "Wikipedia"
-- [piriform cortex](http://purl.obolibrary.org/obo/UBERON_0004725) SubClassOf [regional part of brain](http://purl.obolibrary.org/obo/UBERON_0002616)
+### prostate epithelial cord `http://purl.obolibrary.org/obo/UBERON_0009843`
+#### Removed
+- [prostate epithelial cord](http://purl.obolibrary.org/obo/UBERON_0009843) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [piriform cortex](http://purl.obolibrary.org/obo/UBERON_0004725) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [olfactory cortex](http://purl.obolibrary.org/obo/UBERON_0002894)
-### piriform cortex layer 3 `http://purl.obolibrary.org/obo/UBERON_0014283`
+### prostate field `http://purl.obolibrary.org/obo/UBERON_0009847`
+#### Removed
+- [prostate field](http://purl.obolibrary.org/obo/UBERON_0009847) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-#### Added
-- [piriform cortex layer 3](http://purl.obolibrary.org/obo/UBERON_0014283) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "uberon"
-- [piriform cortex layer 3](http://purl.obolibrary.org/obo/UBERON_0014283) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "piriform cortex layer 3"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "NLXANAT:091009"
-- [piriform cortex layer 3](http://purl.obolibrary.org/obo/UBERON_0014283) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "layer 3 of piriform cortex"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "NLXANAT:091009"
+### prostate glandular acinus `http://purl.obolibrary.org/obo/UBERON_0004179`
+#### Removed
+- [prostate glandular acinus](http://purl.obolibrary.org/obo/UBERON_0004179) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [piriform cortex layer 3](http://purl.obolibrary.org/obo/UBERON_0014283) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "layer 3 of piriform cortex"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "NLXANAT:091009"
-- [piriform cortex layer 3](http://purl.obolibrary.org/obo/UBERON_0014283) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "NLXANAT:091009"
-- [piriform cortex layer 3](http://purl.obolibrary.org/obo/UBERON_0014283) [contributor](http://purl.org/dc/terms/contributor) [0000-0002-8406-3871](https://orcid.org/0000-0002-8406-3871)
+### protein c-Fos `http://purl.obolibrary.org/obo/PR_000007597`
-- [piriform cortex layer 3](http://purl.obolibrary.org/obo/UBERON_0014283) [id](http://www.geneontology.org/formats/oboInOwl#id) "UBERON:0014283"
+#### Added
+- [protein c-Fos](http://purl.obolibrary.org/obo/PR_000007597) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [protein c-Fos (human)](http://purl.obolibrary.org/obo/PR_P01100)
-- [piriform cortex layer 3](http://purl.obolibrary.org/obo/UBERON_0014283) [label](http://www.w3.org/2000/01/rdf-schema#label) "piriform cortex layer 3"
-- [piriform cortex layer 3](http://purl.obolibrary.org/obo/UBERON_0014283) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Deepest of 3 cytoarchitecturally defined layers of the piriform cortex characterized by a moderately high density of pyramidal cells and large numbers of basal dendrites descending from pyramidal cells in layer 2."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "NLXANAT:091009"
+### pulmonary capillary endothelial cell `http://purl.obolibrary.org/obo/CL_4028001`
-- Class: [piriform cortex layer 3](http://purl.obolibrary.org/obo/UBERON_0014283)
+#### Added
+- [pulmonary capillary endothelial cell](http://purl.obolibrary.org/obo/CL_4028001) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [pulmonary capillary](http://purl.obolibrary.org/obo/UBERON_0016405)
-- [piriform cortex layer 3](http://purl.obolibrary.org/obo/UBERON_0014283) SubClassOf [has part](http://purl.obolibrary.org/obo/BFO_0000051) some [pyramidal neuron](http://purl.obolibrary.org/obo/CL_0000598)
-- [piriform cortex layer 3](http://purl.obolibrary.org/obo/UBERON_0014283) SubClassOf [central nervous system cell part cluster](http://purl.obolibrary.org/obo/UBERON_0011215)
+### pulmonary lymphatic vessel `http://purl.obolibrary.org/obo/UBERON_0018227`
-- [piriform cortex layer 3](http://purl.obolibrary.org/obo/UBERON_0014283) SubClassOf [nervous system cell part layer](http://purl.obolibrary.org/obo/UBERON_0022303)
+#### Added
+- [pulmonary lymphatic vessel](http://purl.obolibrary.org/obo/UBERON_0018227) SubClassOf [has part](http://purl.obolibrary.org/obo/BFO_0000051) some [respiratory system lymphatic vessel endothelium](http://purl.obolibrary.org/obo/UBERON_0003529)
-- [piriform cortex layer 3](http://purl.obolibrary.org/obo/UBERON_0014283) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [piriform cortex](http://purl.obolibrary.org/obo/UBERON_0004725)
- - [source](http://www.geneontology.org/formats/oboInOwl#source) "NIFSTD"
+- [pulmonary lymphatic vessel](http://purl.obolibrary.org/obo/UBERON_0018227) SubClassOf [protein-containing material entity](http://purl.obolibrary.org/obo/PR_000050567)
-### platelet `http://purl.obolibrary.org/obo/CL_0000233`
+### pulmonary part of lymphatic system `http://purl.obolibrary.org/obo/UBERON_0018226`
#### Removed
-- [platelet](http://purl.obolibrary.org/obo/CL_0000233) EquivalentTo [myeloid cell](http://purl.obolibrary.org/obo/CL_0000763) and ([bearer of](http://purl.obolibrary.org/obo/RO_0000053) some [anucleate](http://purl.obolibrary.org/obo/PATO_0001405)) and ([bearer of](http://purl.obolibrary.org/obo/RO_0000053) some [discoid](http://purl.obolibrary.org/obo/PATO_0001874)) and ([capable of](http://purl.obolibrary.org/obo/RO_0002215) some [blood coagulation](http://purl.obolibrary.org/obo/GO_0007596)) and ([capable of](http://purl.obolibrary.org/obo/RO_0002215) some [blood circulation](http://purl.obolibrary.org/obo/GO_0008015))
-
-- [platelet](http://purl.obolibrary.org/obo/CL_0000233) SubClassOf [capable of](http://purl.obolibrary.org/obo/RO_0002215) some [blood coagulation](http://purl.obolibrary.org/obo/GO_0007596)
+- [pulmonary part of lymphatic system](http://purl.obolibrary.org/obo/UBERON_0018226) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
#### Added
-- [platelet](http://purl.obolibrary.org/obo/CL_0000233) SubClassOf [capable of part of](http://purl.obolibrary.org/obo/RO_0002216) some [blood coagulation](http://purl.obolibrary.org/obo/GO_0007596)
+- [pulmonary part of lymphatic system](http://purl.obolibrary.org/obo/UBERON_0018226) SubClassOf [protein-containing material entity](http://purl.obolibrary.org/obo/PR_000050567)
-### positive regulation of ATP biosynthetic process `http://purl.obolibrary.org/obo/GO_2001171`
-
-#### Added
-- [positive regulation of ATP biosynthetic process](http://purl.obolibrary.org/obo/GO_2001171) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "positive regulation of ATP biosynthesis"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:obol"
+### pulmonary vascular system `http://purl.obolibrary.org/obo/UBERON_0008886`
+#### Removed
+- [pulmonary vascular system](http://purl.obolibrary.org/obo/UBERON_0008886) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-- [positive regulation of ATP biosynthetic process](http://purl.obolibrary.org/obo/GO_2001171) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "positive regulation of ATP regeneration"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:obol"
-- [positive regulation of ATP biosynthetic process](http://purl.obolibrary.org/obo/GO_2001171) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2011-10-26T03:18:26Z"
-- [positive regulation of ATP biosynthetic process](http://purl.obolibrary.org/obo/GO_2001171) [label](http://www.w3.org/2000/01/rdf-schema#label) "positive regulation of ATP biosynthetic process"
+### pvalb GABAergic cortical interneuron `http://purl.obolibrary.org/obo/CL_4023018`
-- [positive regulation of ATP biosynthetic process](http://purl.obolibrary.org/obo/GO_2001171) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "positive regulation of ATP formation"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:obol"
+#### Added
+- [pvalb GABAergic cortical interneuron](http://purl.obolibrary.org/obo/CL_4023018) [symbol](http://purl.obolibrary.org/obo/IAO_0000028) "pvalb cortical interneuron"
-- [positive regulation of ATP biosynthetic process](http://purl.obolibrary.org/obo/GO_2001171) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "positive regulation of ATP synthesis"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:obol"
-- [positive regulation of ATP biosynthetic process](http://purl.obolibrary.org/obo/GO_2001171) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "kmv"
+### pyloric antrum `http://purl.obolibrary.org/obo/UBERON_0001165`
+#### Removed
+- [pyloric antrum](http://purl.obolibrary.org/obo/UBERON_0001165) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [positive regulation of ATP biosynthetic process](http://purl.obolibrary.org/obo/GO_2001171) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process"
-- [positive regulation of ATP biosynthetic process](http://purl.obolibrary.org/obo/GO_2001171) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that activates or increases the frequency, rate or extent of ATP biosynthetic process."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:obol"
-- [positive regulation of ATP biosynthetic process](http://purl.obolibrary.org/obo/GO_2001171) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "positive regulation of ATP anabolism"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:obol"
+### pylorus `http://purl.obolibrary.org/obo/UBERON_0001166`
+#### Removed
+- [pylorus](http://purl.obolibrary.org/obo/UBERON_0001166) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-- [positive regulation of ATP biosynthetic process](http://purl.obolibrary.org/obo/GO_2001171) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:2001171"
-- Class: [positive regulation of ATP biosynthetic process](http://purl.obolibrary.org/obo/GO_2001171)
-- [positive regulation of ATP biosynthetic process](http://purl.obolibrary.org/obo/GO_2001171) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([positively regulates](http://purl.obolibrary.org/obo/RO_0002213) some [ATP biosynthetic process](http://purl.obolibrary.org/obo/GO_0006754))
+### ready for release `http://purl.obolibrary.org/obo/IAO_0000122`
-- [positive regulation of ATP biosynthetic process](http://purl.obolibrary.org/obo/GO_2001171) SubClassOf [positive regulation of ATP metabolic process](http://purl.obolibrary.org/obo/GO_1903580)
+#### Added
+- [ready for release](http://purl.obolibrary.org/obo/IAO_0000122) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "ready for release"@en
-- [positive regulation of ATP biosynthetic process](http://purl.obolibrary.org/obo/GO_2001171) SubClassOf [positively regulates](http://purl.obolibrary.org/obo/RO_0002213) some [ATP biosynthetic process](http://purl.obolibrary.org/obo/GO_0006754)
+- [ready for release](http://purl.obolibrary.org/obo/IAO_0000122) [label](http://www.w3.org/2000/01/rdf-schema#label) "ready for release"@en
-- [positive regulation of ATP biosynthetic process](http://purl.obolibrary.org/obo/GO_2001171) SubClassOf [positive regulation of biosynthetic process](http://purl.obolibrary.org/obo/GO_0009891)
+- [ready for release](http://purl.obolibrary.org/obo/IAO_0000122) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Class has undergone final review, is ready for use, and will be included in the next release. Any class lacking "ready_for_release" should be considered likely to change place in hierarchy, have its definition refined, or be obsoleted in the next release. Those classes deemed "ready_for_release" will also derived from a chain of ancestor classes that are also "ready_for_release.""@en
-- [positive regulation of ATP biosynthetic process](http://purl.obolibrary.org/obo/GO_2001171) SubClassOf [regulation of ATP biosynthetic process](http://purl.obolibrary.org/obo/GO_2001169)
+- Individual: [ready for release](http://purl.obolibrary.org/obo/IAO_0000122)
-### positive regulation of ATP metabolic process `http://purl.obolibrary.org/obo/GO_1903580`
+### receptor-type tyrosine-protein kinase FLT3 `http://purl.obolibrary.org/obo/PR_000002001`
#### Added
-- [positive regulation of ATP metabolic process](http://purl.obolibrary.org/obo/GO_1903580) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "sl"
+- [receptor-type tyrosine-protein kinase FLT3](http://purl.obolibrary.org/obo/PR_000002001) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [receptor-type tyrosine-protein kinase FLT3 (human)](http://purl.obolibrary.org/obo/PR_P36888)
-- [positive regulation of ATP metabolic process](http://purl.obolibrary.org/obo/GO_1903580) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that activates or increases the frequency, rate or extent of ATP metabolic process."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:20695849"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie"
+### receptor-type tyrosine-protein phosphatase C `http://purl.obolibrary.org/obo/PR_000001006`
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GO_REF:0000058"
+#### Added
+- [receptor-type tyrosine-protein phosphatase C](http://purl.obolibrary.org/obo/PR_000001006) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [receptor-type tyrosine-protein phosphatase C (human)](http://purl.obolibrary.org/obo/PR_P08575)
-- [positive regulation of ATP metabolic process](http://purl.obolibrary.org/obo/GO_1903580) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "positive regulation of ATP metabolism"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie"
-- [positive regulation of ATP metabolic process](http://purl.obolibrary.org/obo/GO_1903580) [label](http://www.w3.org/2000/01/rdf-schema#label) "positive regulation of ATP metabolic process"
+### receptor-type tyrosine-protein phosphatase C isoform CD45RA `http://purl.obolibrary.org/obo/PR_000001015`
-- [positive regulation of ATP metabolic process](http://purl.obolibrary.org/obo/GO_1903580) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "up-regulation of ATP metabolism"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie"
+#### Added
+- [receptor-type tyrosine-protein phosphatase C isoform CD45RA](http://purl.obolibrary.org/obo/PR_000001015) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [receptor-type tyrosine-protein phosphatase C isoform CD45RA (human)](http://purl.obolibrary.org/obo/PR_P08575-8)
-- [positive regulation of ATP metabolic process](http://purl.obolibrary.org/obo/GO_1903580) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "up regulation of ATP metabolic process"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie"
-- [positive regulation of ATP metabolic process](http://purl.obolibrary.org/obo/GO_1903580) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "up-regulation of ATP metabolic process"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie"
+### receptor-type tyrosine-protein phosphatase C isoform CD45RABC `http://purl.obolibrary.org/obo/PR_000001014`
-- [positive regulation of ATP metabolic process](http://purl.obolibrary.org/obo/GO_1903580) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "up regulation of ATP metabolism"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie"
+#### Added
+- [receptor-type tyrosine-protein phosphatase C isoform CD45RABC](http://purl.obolibrary.org/obo/PR_000001014) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [receptor-type tyrosine-protein phosphatase C isoform CD45RABC (human)](http://purl.obolibrary.org/obo/PR_P08575-3)
-- [positive regulation of ATP metabolic process](http://purl.obolibrary.org/obo/GO_1903580) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "activation of ATP metabolism"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie"
-- [positive regulation of ATP metabolic process](http://purl.obolibrary.org/obo/GO_1903580) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "upregulation of ATP metabolism"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie"
+### receptor-type tyrosine-protein phosphatase C isoform CD45RO `http://purl.obolibrary.org/obo/PR_000001017`
-- [positive regulation of ATP metabolic process](http://purl.obolibrary.org/obo/GO_1903580) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2014-10-30T19:04:42Z"
+#### Added
+- [receptor-type tyrosine-protein phosphatase C isoform CD45RO](http://purl.obolibrary.org/obo/PR_000001017) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [receptor-type tyrosine-protein phosphatase C isoform CD45RO (human)](http://purl.obolibrary.org/obo/PR_P08575-4)
-- [positive regulation of ATP metabolic process](http://purl.obolibrary.org/obo/GO_1903580) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "activation of ATP metabolic process"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie"
-- [positive regulation of ATP metabolic process](http://purl.obolibrary.org/obo/GO_1903580) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process"
+### rectal lumen `http://purl.obolibrary.org/obo/UBERON_0009670`
+#### Removed
+- [rectal lumen](http://purl.obolibrary.org/obo/UBERON_0009670) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [positive regulation of ATP metabolic process](http://purl.obolibrary.org/obo/GO_1903580) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:1903580"
-- [positive regulation of ATP metabolic process](http://purl.obolibrary.org/obo/GO_1903580) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "upregulation of ATP metabolic process"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie"
-- Class: [positive regulation of ATP metabolic process](http://purl.obolibrary.org/obo/GO_1903580)
+### red pulp of spleen `http://purl.obolibrary.org/obo/UBERON_0001250`
+#### Removed
+- [red pulp of spleen](http://purl.obolibrary.org/obo/UBERON_0001250) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [positive regulation of ATP metabolic process](http://purl.obolibrary.org/obo/GO_1903580) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([positively regulates](http://purl.obolibrary.org/obo/RO_0002213) some [ATP metabolic process](http://purl.obolibrary.org/obo/GO_0046034))
-- [positive regulation of ATP metabolic process](http://purl.obolibrary.org/obo/GO_1903580) SubClassOf [regulation of ATP metabolic process](http://purl.obolibrary.org/obo/GO_1903578)
-- [positive regulation of ATP metabolic process](http://purl.obolibrary.org/obo/GO_1903580) SubClassOf [positive regulation of metabolic process](http://purl.obolibrary.org/obo/GO_0009893)
+### reelin `http://purl.obolibrary.org/obo/PR_000013879`
-- [positive regulation of ATP metabolic process](http://purl.obolibrary.org/obo/GO_1903580) SubClassOf [positively regulates](http://purl.obolibrary.org/obo/RO_0002213) some [ATP metabolic process](http://purl.obolibrary.org/obo/GO_0046034)
+#### Added
+- [reelin](http://purl.obolibrary.org/obo/PR_000013879) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [reelin (human)](http://purl.obolibrary.org/obo/PR_P78509)
-### positive regulation of ATP-dependent activity `http://purl.obolibrary.org/obo/GO_0032781`
+### regional part of brain `http://purl.obolibrary.org/obo/UBERON_0002616`
#### Removed
-- [positive regulation of ATP-dependent activity](http://purl.obolibrary.org/obo/GO_0032781) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [term_scheduled_for_obsoletion](http://purl.obolibrary.org/obo/go#term_scheduled_for_obsoletion)
+- [regional part of brain](http://purl.obolibrary.org/obo/UBERON_0002616) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-#### Added
-- [positive regulation of ATP-dependent activity](http://purl.obolibrary.org/obo/GO_0032781) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate)
-### positive regulation of DNA binding `http://purl.obolibrary.org/obo/GO_0043388`
+### regular connective tissue `http://purl.obolibrary.org/obo/UBERON_0007845`
#### Removed
-- [positive regulation of DNA binding](http://purl.obolibrary.org/obo/GO_0043388) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [term_scheduled_for_obsoletion](http://purl.obolibrary.org/obo/go#term_scheduled_for_obsoletion)
+- [regular connective tissue](http://purl.obolibrary.org/obo/UBERON_0007845) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-#### Added
-- [positive regulation of DNA binding](http://purl.obolibrary.org/obo/GO_0043388) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate)
-### positive regulation of RNA binding `http://purl.obolibrary.org/obo/GO_1905216`
-#### Removed
-- [positive regulation of RNA binding](http://purl.obolibrary.org/obo/GO_1905216) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [term_scheduled_for_obsoletion](http://purl.obolibrary.org/obo/go#term_scheduled_for_obsoletion)
+### relaxin receptor 1 `http://purl.obolibrary.org/obo/PR_000001666`
#### Added
-- [positive regulation of RNA binding](http://purl.obolibrary.org/obo/GO_1905216) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate)
+- [relaxin receptor 1](http://purl.obolibrary.org/obo/PR_000001666) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [relaxin receptor 1 (human)](http://purl.obolibrary.org/obo/PR_Q9HBX9)
-### positive regulation of binding `http://purl.obolibrary.org/obo/GO_0051099`
+### renal lobule `http://purl.obolibrary.org/obo/UBERON_0009914`
#### Removed
-- [positive regulation of binding](http://purl.obolibrary.org/obo/GO_0051099) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [term_scheduled_for_obsoletion](http://purl.obolibrary.org/obo/go#term_scheduled_for_obsoletion)
+- [renal lobule](http://purl.obolibrary.org/obo/UBERON_0009914) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-#### Added
-- [positive regulation of binding](http://purl.obolibrary.org/obo/GO_0051099) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate)
-### positive regulation of calcium ion binding `http://purl.obolibrary.org/obo/GO_1901878`
+### renal vesicle `http://purl.obolibrary.org/obo/UBERON_0004209`
#### Removed
-- [positive regulation of calcium ion binding](http://purl.obolibrary.org/obo/GO_1901878) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [term_scheduled_for_obsoletion](http://purl.obolibrary.org/obo/go#term_scheduled_for_obsoletion)
+- [renal vesicle](http://purl.obolibrary.org/obo/UBERON_0004209) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-#### Added
-- [positive regulation of calcium ion binding](http://purl.obolibrary.org/obo/GO_1901878) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate)
-### positive regulation of calcium ion transmembrane transporter activity `http://purl.obolibrary.org/obo/GO_1901021`
-#### Removed
-- [positive regulation of calcium ion transmembrane transporter activity](http://purl.obolibrary.org/obo/GO_1901021) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [term_scheduled_for_obsoletion](http://purl.obolibrary.org/obo/go#term_scheduled_for_obsoletion)
+### renin `http://purl.obolibrary.org/obo/PR_000013883`
#### Added
-- [positive regulation of calcium ion transmembrane transporter activity](http://purl.obolibrary.org/obo/GO_1901021) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate)
+- [renin](http://purl.obolibrary.org/obo/PR_000013883) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [renin (human)](http://purl.obolibrary.org/obo/PR_P00797)
-### positive regulation of catalytic activity `http://purl.obolibrary.org/obo/GO_0043085`
+### reproductive system `http://purl.obolibrary.org/obo/UBERON_0000990`
#### Removed
-- [positive regulation of catalytic activity](http://purl.obolibrary.org/obo/GO_0043085) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [term_scheduled_for_obsoletion](http://purl.obolibrary.org/obo/go#term_scheduled_for_obsoletion)
+- [reproductive system](http://purl.obolibrary.org/obo/UBERON_0000990) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-#### Added
-- [positive regulation of catalytic activity](http://purl.obolibrary.org/obo/GO_0043085) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate)
-### positive regulation of cation channel activity `http://purl.obolibrary.org/obo/GO_2001259`
-#### Removed
-- [positive regulation of cation channel activity](http://purl.obolibrary.org/obo/GO_2001259) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [term_scheduled_for_obsoletion](http://purl.obolibrary.org/obo/go#term_scheduled_for_obsoletion)
+### requires discussion `http://purl.obolibrary.org/obo/IAO_0000428`
#### Added
-- [positive regulation of cation channel activity](http://purl.obolibrary.org/obo/GO_2001259) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate)
+- [requires discussion](http://purl.obolibrary.org/obo/IAO_0000428) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A term that is metadata complete, has been reviewed, and problems have been identified that require discussion before release. Such a term requires editor note(s) to identify the outstanding issues."@en
+- [requires discussion](http://purl.obolibrary.org/obo/IAO_0000428) [IAO_0000119](http://purl.obolibrary.org/obo/IAO_0000119) "group:OBI"@en
-### positive regulation of chromatin binding `http://purl.obolibrary.org/obo/GO_0035563`
-#### Removed
-- [positive regulation of chromatin binding](http://purl.obolibrary.org/obo/GO_0035563) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [term_scheduled_for_obsoletion](http://purl.obolibrary.org/obo/go#term_scheduled_for_obsoletion)
-
-#### Added
-- [positive regulation of chromatin binding](http://purl.obolibrary.org/obo/GO_0035563) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate)
+- [requires discussion](http://purl.obolibrary.org/obo/IAO_0000428) [label](http://www.w3.org/2000/01/rdf-schema#label) "requires discussion"@en
+- [requires discussion](http://purl.obolibrary.org/obo/IAO_0000428) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "requires discussion"@en
-### positive regulation of collagen binding `http://purl.obolibrary.org/obo/GO_0033343`
-#### Removed
-- [positive regulation of collagen binding](http://purl.obolibrary.org/obo/GO_0033343) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [term_scheduled_for_obsoletion](http://purl.obolibrary.org/obo/go#term_scheduled_for_obsoletion)
+- [requires discussion](http://purl.obolibrary.org/obo/IAO_0000428) [IAO_0000117](http://purl.obolibrary.org/obo/IAO_0000117) "Alan Ruttenberg"@en
-#### Added
-- [positive regulation of collagen binding](http://purl.obolibrary.org/obo/GO_0033343) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate)
+- Individual: [requires discussion](http://purl.obolibrary.org/obo/IAO_0000428)
-### positive regulation of deoxyribonuclease activity `http://purl.obolibrary.org/obo/GO_0032077`
+### respiratory primordium `http://purl.obolibrary.org/obo/UBERON_0008947`
#### Removed
-- [positive regulation of deoxyribonuclease activity](http://purl.obolibrary.org/obo/GO_0032077) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [term_scheduled_for_obsoletion](http://purl.obolibrary.org/obo/go#term_scheduled_for_obsoletion)
+- [respiratory primordium](http://purl.obolibrary.org/obo/UBERON_0008947) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-#### Added
-- [positive regulation of deoxyribonuclease activity](http://purl.obolibrary.org/obo/GO_0032077) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate)
-### positive regulation of euchromatin binding `http://purl.obolibrary.org/obo/GO_1904795`
+### respiratory primordium mesenchyme `http://purl.obolibrary.org/obo/UBERON_0036073`
#### Removed
-- [positive regulation of euchromatin binding](http://purl.obolibrary.org/obo/GO_1904795) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [term_scheduled_for_obsoletion](http://purl.obolibrary.org/obo/go#term_scheduled_for_obsoletion)
+- [respiratory primordium mesenchyme](http://purl.obolibrary.org/obo/UBERON_0036073) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-#### Added
-- [positive regulation of euchromatin binding](http://purl.obolibrary.org/obo/GO_1904795) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate)
-### positive regulation of hydrolase activity `http://purl.obolibrary.org/obo/GO_0051345`
+### results in acquisition of features of `http://purl.obolibrary.org/obo/RO_0002315`
#### Removed
-- [positive regulation of hydrolase activity](http://purl.obolibrary.org/obo/GO_0051345) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [term_scheduled_for_obsoletion](http://purl.obolibrary.org/obo/go#term_scheduled_for_obsoletion)
+- [results in acquisition of features of](http://purl.obolibrary.org/obo/RO_0002315) Range [connected anatomical structure](http://purl.obolibrary.org/obo/CARO_0000003)
#### Added
-- [positive regulation of hydrolase activity](http://purl.obolibrary.org/obo/GO_0051345) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate)
+- [results in acquisition of features of](http://purl.obolibrary.org/obo/RO_0002315) Range [anatomical structure](http://purl.obolibrary.org/obo/UBERON_0000061)
-### positive regulation of ion transmembrane transporter activity `http://purl.obolibrary.org/obo/GO_0032414`
+### results in developmental progression of `http://purl.obolibrary.org/obo/RO_0002295`
#### Removed
-- [positive regulation of ion transmembrane transporter activity](http://purl.obolibrary.org/obo/GO_0032414) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [term_scheduled_for_obsoletion](http://purl.obolibrary.org/obo/go#term_scheduled_for_obsoletion)
+- [results in developmental progression of](http://purl.obolibrary.org/obo/RO_0002295) Range [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
#### Added
-- [positive regulation of ion transmembrane transporter activity](http://purl.obolibrary.org/obo/GO_0032414) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate)
+- [results in developmental progression of](http://purl.obolibrary.org/obo/RO_0002295) Range [anatomical entity](http://purl.obolibrary.org/obo/UBERON_0001062)
-### positive regulation of iron ion transmembrane transporter activity `http://purl.obolibrary.org/obo/GO_1904256`
+### results in fusion of `http://purl.obolibrary.org/obo/RO_0012008`
#### Removed
-- [positive regulation of iron ion transmembrane transporter activity](http://purl.obolibrary.org/obo/GO_1904256) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [term_scheduled_for_obsoletion](http://purl.obolibrary.org/obo/go#term_scheduled_for_obsoletion)
+- [results in fusion of](http://purl.obolibrary.org/obo/RO_0012008) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "pg"
#### Added
-- [positive regulation of iron ion transmembrane transporter activity](http://purl.obolibrary.org/obo/GO_1904256) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate)
+- [results in fusion of](http://purl.obolibrary.org/obo/RO_0012008) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) [0000-0003-1813-6857](https://orcid.org/0000-0003-1813-6857)
-### positive regulation of kinase activity `http://purl.obolibrary.org/obo/GO_0033674`
+### reticulocyte `http://purl.obolibrary.org/obo/CL_0000558`
#### Removed
-- [positive regulation of kinase activity](http://purl.obolibrary.org/obo/GO_0033674) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [term_scheduled_for_obsoletion](http://purl.obolibrary.org/obo/go#term_scheduled_for_obsoletion)
+- [reticulocyte](http://purl.obolibrary.org/obo/CL_0000558) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-#### Added
-- [positive regulation of kinase activity](http://purl.obolibrary.org/obo/GO_0033674) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate)
-### positive regulation of ligase activity `http://purl.obolibrary.org/obo/GO_0051351`
+### reticulospinal neuron `http://purl.obolibrary.org/obo/CL_4023107`
#### Removed
-- [positive regulation of ligase activity](http://purl.obolibrary.org/obo/GO_0051351) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [term_scheduled_for_obsoletion](http://purl.obolibrary.org/obo/go#term_scheduled_for_obsoletion)
+- [reticulospinal neuron](http://purl.obolibrary.org/obo/CL_4023107) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-#### Added
-- [positive regulation of ligase activity](http://purl.obolibrary.org/obo/GO_0051351) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate)
-### positive regulation of lipid binding `http://purl.obolibrary.org/obo/GO_1900132`
+### retina horizontal cell `http://purl.obolibrary.org/obo/CL_0000745`
#### Removed
-- [positive regulation of lipid binding](http://purl.obolibrary.org/obo/GO_1900132) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [term_scheduled_for_obsoletion](http://purl.obolibrary.org/obo/go#term_scheduled_for_obsoletion)
+- [retina horizontal cell](http://purl.obolibrary.org/obo/CL_0000745) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
#### Added
-- [positive regulation of lipid binding](http://purl.obolibrary.org/obo/GO_1900132) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate)
+- [retina horizontal cell](http://purl.obolibrary.org/obo/CL_0000745) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "HCs"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [plural term](http://purl.obolibrary.org/obo/uberon#PLURAL)
-### positive regulation of lipid transporter activity `http://purl.obolibrary.org/obo/GO_0110113`
-#### Removed
-- [positive regulation of lipid transporter activity](http://purl.obolibrary.org/obo/GO_0110113) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [term_scheduled_for_obsoletion](http://purl.obolibrary.org/obo/go#term_scheduled_for_obsoletion)
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1038/s41598-020-66092-9"
-#### Added
-- [positive regulation of lipid transporter activity](http://purl.obolibrary.org/obo/GO_0110113) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate)
+- [retina horizontal cell](http://purl.obolibrary.org/obo/CL_0000745) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "HC"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1038/s41598-020-66092-9"
-### positive regulation of microtubule binding `http://purl.obolibrary.org/obo/GO_1904528`
-#### Removed
-- [positive regulation of microtubule binding](http://purl.obolibrary.org/obo/GO_1904528) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [term_scheduled_for_obsoletion](http://purl.obolibrary.org/obo/go#term_scheduled_for_obsoletion)
-#### Added
-- [positive regulation of microtubule binding](http://purl.obolibrary.org/obo/GO_1904528) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate)
+### retinal bipolar neuron `http://purl.obolibrary.org/obo/CL_0000748`
+#### Removed
+- [retinal bipolar neuron](http://purl.obolibrary.org/obo/CL_0000748) EquivalentTo [bipolar neuron](http://purl.obolibrary.org/obo/CL_0000103) and ([has soma location](http://purl.obolibrary.org/obo/RO_0002100) some [retina](http://purl.obolibrary.org/obo/UBERON_0000966))
+- [retinal bipolar neuron](http://purl.obolibrary.org/obo/CL_0000748) SubClassOf [has soma location](http://purl.obolibrary.org/obo/RO_0002100) some [retina](http://purl.obolibrary.org/obo/UBERON_0000966)
-### positive regulation of molecular function `http://purl.obolibrary.org/obo/GO_0044093`
-#### Removed
-- [positive regulation of molecular function](http://purl.obolibrary.org/obo/GO_0044093) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [term_scheduled_for_obsoletion](http://purl.obolibrary.org/obo/go#term_scheduled_for_obsoletion)
+- [retinal bipolar neuron](http://purl.obolibrary.org/obo/CL_0000748) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
#### Added
-- [positive regulation of molecular function](http://purl.obolibrary.org/obo/GO_0044093) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate)
+- [retinal bipolar neuron](http://purl.obolibrary.org/obo/CL_0000748) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "BCs"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [plural term](http://purl.obolibrary.org/obo/uberon#PLURAL)
-### positive regulation of nuclease activity `http://purl.obolibrary.org/obo/GO_0032075`
-#### Removed
-- [positive regulation of nuclease activity](http://purl.obolibrary.org/obo/GO_0032075) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [term_scheduled_for_obsoletion](http://purl.obolibrary.org/obo/go#term_scheduled_for_obsoletion)
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1038/s41598-020-66092-9"
-#### Added
-- [positive regulation of nuclease activity](http://purl.obolibrary.org/obo/GO_0032075) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate)
+- [retinal bipolar neuron](http://purl.obolibrary.org/obo/CL_0000748) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "BC"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1038/s41598-020-66092-9"
-### positive regulation of peptidase activity `http://purl.obolibrary.org/obo/GO_0010952`
-#### Removed
-- [positive regulation of peptidase activity](http://purl.obolibrary.org/obo/GO_0010952) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [term_scheduled_for_obsoletion](http://purl.obolibrary.org/obo/go#term_scheduled_for_obsoletion)
+- [retinal bipolar neuron](http://purl.obolibrary.org/obo/CL_0000748) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "BPs"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
-- [positive regulation of peptidase activity](http://purl.obolibrary.org/obo/GO_0010952) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that increases the frequency, rate or extent of peptidase activity, the hydrolysis of peptide bonds within proteins."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dph"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [plural term](http://purl.obolibrary.org/obo/uberon#PLURAL)
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:tb"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GSE137537"
-- [positive regulation of peptidase activity](http://purl.obolibrary.org/obo/GO_0010952) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0010952"
+- [retinal bipolar neuron](http://purl.obolibrary.org/obo/CL_0000748) EquivalentTo [bipolar neuron](http://purl.obolibrary.org/obo/CL_0000103) and ([has soma location](http://purl.obolibrary.org/obo/RO_0002100) some [inner nuclear layer of retina](http://purl.obolibrary.org/obo/UBERON_0001791))
-- [positive regulation of peptidase activity](http://purl.obolibrary.org/obo/GO_0010952) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2009-04-27T11:54:32Z"
+- [retinal bipolar neuron](http://purl.obolibrary.org/obo/CL_0000748) SubClassOf [has soma location](http://purl.obolibrary.org/obo/RO_0002100) some [inner nuclear layer of retina](http://purl.obolibrary.org/obo/UBERON_0001791)
-- [positive regulation of peptidase activity](http://purl.obolibrary.org/obo/GO_0010952) [label](http://www.w3.org/2000/01/rdf-schema#label) "positive regulation of peptidase activity"
-- [positive regulation of peptidase activity](http://purl.obolibrary.org/obo/GO_0010952) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "tb"
+### retinal cone cell `http://purl.obolibrary.org/obo/CL_0000573`
-- [positive regulation of peptidase activity](http://purl.obolibrary.org/obo/GO_0010952) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process"
+#### Added
+- [retinal cone cell](http://purl.obolibrary.org/obo/CL_0000573) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "cone"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1038/s41598-020-66092-9"
-- Class: [positive regulation of peptidase activity](http://purl.obolibrary.org/obo/GO_0010952)
-- [positive regulation of peptidase activity](http://purl.obolibrary.org/obo/GO_0010952) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([positively regulates](http://purl.obolibrary.org/obo/RO_0002213) some [peptidase activity](http://purl.obolibrary.org/obo/GO_0008233))
+### retinal ganglion cell `http://purl.obolibrary.org/obo/CL_0000740`
+#### Removed
+- [retinal ganglion cell](http://purl.obolibrary.org/obo/CL_0000740) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "RGC"
-- [positive regulation of peptidase activity](http://purl.obolibrary.org/obo/GO_0010952) SubClassOf [positively regulates](http://purl.obolibrary.org/obo/RO_0002213) some [peptidase activity](http://purl.obolibrary.org/obo/GO_0008233)
+#### Added
+- [retinal ganglion cell](http://purl.obolibrary.org/obo/CL_0000740) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "RGCs"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
-- [positive regulation of peptidase activity](http://purl.obolibrary.org/obo/GO_0010952) SubClassOf [regulation of peptidase activity](http://purl.obolibrary.org/obo/GO_0052547)
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [plural term](http://purl.obolibrary.org/obo/uberon#PLURAL)
-- [positive regulation of peptidase activity](http://purl.obolibrary.org/obo/GO_0010952) SubClassOf [positive regulation of hydrolase activity](http://purl.obolibrary.org/obo/GO_0051345)
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1038/s41598-020-66092-9"
-- [positive regulation of peptidase activity](http://purl.obolibrary.org/obo/GO_0010952) SubClassOf [positive regulation of proteolysis](http://purl.obolibrary.org/obo/GO_0045862)
+- [retinal ganglion cell](http://purl.obolibrary.org/obo/CL_0000740) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "RGC"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1038/s41598-020-66092-9"
-### positive regulation of protein binding `http://purl.obolibrary.org/obo/GO_0032092`
+### retinal neural layer `http://purl.obolibrary.org/obo/UBERON_0003902`
#### Removed
-- [positive regulation of protein binding](http://purl.obolibrary.org/obo/GO_0032092) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [term_scheduled_for_obsoletion](http://purl.obolibrary.org/obo/go#term_scheduled_for_obsoletion)
+- [retinal neural layer](http://purl.obolibrary.org/obo/UBERON_0003902) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-#### Added
-- [positive regulation of protein binding](http://purl.obolibrary.org/obo/GO_0032092) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate)
-### positive regulation of protein kinase activity `http://purl.obolibrary.org/obo/GO_0045860`
+### retinal progenitor cell `http://purl.obolibrary.org/obo/CL_0002672`
#### Removed
-- [positive regulation of protein kinase activity](http://purl.obolibrary.org/obo/GO_0045860) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [term_scheduled_for_obsoletion](http://purl.obolibrary.org/obo/go#term_scheduled_for_obsoletion)
+- [retinal progenitor cell](http://purl.obolibrary.org/obo/CL_0002672) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-#### Added
-- [positive regulation of protein kinase activity](http://purl.obolibrary.org/obo/GO_0045860) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate)
-### positive regulation of protein serine/threonine kinase activity `http://purl.obolibrary.org/obo/GO_0071902`
-#### Removed
-- [positive regulation of protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0071902) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [term_scheduled_for_obsoletion](http://purl.obolibrary.org/obo/go#term_scheduled_for_obsoletion)
+### retinal rod cell `http://purl.obolibrary.org/obo/CL_0000604`
#### Added
-- [positive regulation of protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0071902) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate)
+- [retinal rod cell](http://purl.obolibrary.org/obo/CL_0000604) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "rod"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1038/s41598-020-66092-9"
-### positive regulation of protein tyrosine kinase activity `http://purl.obolibrary.org/obo/GO_0061098`
+### retrotrapezoid nucleus neuron `http://purl.obolibrary.org/obo/CL_1000001`
#### Removed
-- [positive regulation of protein tyrosine kinase activity](http://purl.obolibrary.org/obo/GO_0061098) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [term_scheduled_for_obsoletion](http://purl.obolibrary.org/obo/go#term_scheduled_for_obsoletion)
+- [retrotrapezoid nucleus neuron](http://purl.obolibrary.org/obo/CL_1000001) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-#### Added
-- [positive regulation of protein tyrosine kinase activity](http://purl.obolibrary.org/obo/GO_0061098) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate)
-### positive regulation of receptor binding `http://purl.obolibrary.org/obo/GO_1900122`
-#### Removed
-- [positive regulation of receptor binding](http://purl.obolibrary.org/obo/GO_1900122) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [term_scheduled_for_obsoletion](http://purl.obolibrary.org/obo/go#term_scheduled_for_obsoletion)
+### rhombomere 1 `http://purl.obolibrary.org/obo/UBERON_0005499`
#### Added
-- [positive regulation of receptor binding](http://purl.obolibrary.org/obo/GO_1900122) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate)
+- [rhombomere 1](http://purl.obolibrary.org/obo/UBERON_0005499) [UBPROP_0000001](http://purl.obolibrary.org/obo/UBPROP_0000001) "Hindbrain segment or neuromere. Kimmel et al, 1995.[TAO]"
+ - [source](http://www.geneontology.org/formats/oboInOwl#source) "ZFIN:curator"
+ - [external_class](http://www.geneontology.org/formats/oboInOwl#external_class) "TAO:0001031"
-### positive regulation of signaling receptor activity `http://purl.obolibrary.org/obo/GO_2000273`
-#### Removed
-- [positive regulation of signaling receptor activity](http://purl.obolibrary.org/obo/GO_2000273) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [term_scheduled_for_obsoletion](http://purl.obolibrary.org/obo/go#term_scheduled_for_obsoletion)
+ - [ontology](http://www.geneontology.org/formats/oboInOwl#ontology) "TAO"
-#### Added
-- [positive regulation of signaling receptor activity](http://purl.obolibrary.org/obo/GO_2000273) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate)
+ - [date_retrieved](http://www.geneontology.org/formats/oboInOwl#date_retrieved) "2012-08-14"
+- [rhombomere 1](http://purl.obolibrary.org/obo/UBERON_0005499) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "DMBA:16915"
-### positive regulation of transferase activity `http://purl.obolibrary.org/obo/GO_0051347`
-#### Removed
-- [positive regulation of transferase activity](http://purl.obolibrary.org/obo/GO_0051347) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [term_scheduled_for_obsoletion](http://purl.obolibrary.org/obo/go#term_scheduled_for_obsoletion)
+- [rhombomere 1](http://purl.obolibrary.org/obo/UBERON_0005499) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "r1"
+ - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [ABBREVIATION](http://purl.obolibrary.org/obo/uberon/core#ABBREVIATION)
-#### Added
-- [positive regulation of transferase activity](http://purl.obolibrary.org/obo/GO_0051347) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate)
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ZFA:0001031"
+- [rhombomere 1](http://purl.obolibrary.org/obo/UBERON_0005499) [UBPROP_0000111](http://purl.obolibrary.org/obo/UBPROP_0000111) "1"^^[nonNegativeInteger](http://www.w3.org/2001/XMLSchema#nonNegativeInteger)
-### positive regulation of transporter activity `http://purl.obolibrary.org/obo/GO_0032411`
-#### Removed
-- [positive regulation of transporter activity](http://purl.obolibrary.org/obo/GO_0032411) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [term_scheduled_for_obsoletion](http://purl.obolibrary.org/obo/go#term_scheduled_for_obsoletion)
+- [rhombomere 1](http://purl.obolibrary.org/obo/UBERON_0005499) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "EMAPA:16290"
-#### Added
-- [positive regulation of transporter activity](http://purl.obolibrary.org/obo/GO_0032411) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate)
+- [rhombomere 1](http://purl.obolibrary.org/obo/UBERON_0005499) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "uberon"
+- [rhombomere 1](http://purl.obolibrary.org/obo/UBERON_0005499) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [efo_slim](http://purl.obolibrary.org/obo/uberon/core#efo_slim)
-### positive regulation of water channel activity `http://purl.obolibrary.org/obo/GO_1902429`
-#### Removed
-- [positive regulation of water channel activity](http://purl.obolibrary.org/obo/GO_1902429) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [term_scheduled_for_obsoletion](http://purl.obolibrary.org/obo/go#term_scheduled_for_obsoletion)
+- [rhombomere 1](http://purl.obolibrary.org/obo/UBERON_0005499) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "TAO:0001031"
-#### Added
-- [positive regulation of water channel activity](http://purl.obolibrary.org/obo/GO_1902429) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate)
+- [rhombomere 1](http://purl.obolibrary.org/obo/UBERON_0005499) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "EHDAA2:0001637"
+- [rhombomere 1](http://purl.obolibrary.org/obo/UBERON_0005499) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "FMA:295790"
-### protein phosphorylation `http://purl.obolibrary.org/obo/GO_0006468`
-#### Removed
-- [protein phosphorylation](http://purl.obolibrary.org/obo/GO_0006468) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [term_scheduled_for_obsoletion](http://purl.obolibrary.org/obo/go#term_scheduled_for_obsoletion)
+- [rhombomere 1](http://purl.obolibrary.org/obo/UBERON_0005499) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "EFO:0003608"
-#### Added
-- [protein phosphorylation](http://purl.obolibrary.org/obo/GO_0006468) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate)
+- [rhombomere 1](http://purl.obolibrary.org/obo/UBERON_0005499) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [pheno_slim](http://purl.obolibrary.org/obo/uberon/core#pheno_slim)
+- [rhombomere 1](http://purl.obolibrary.org/obo/UBERON_0005499) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "DHBA:12667"
-### protein serine/threonine kinase activity `http://purl.obolibrary.org/obo/GO_0004674`
-#### Removed
-- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "EC:2.7.11.1"
- - [source](http://www.geneontology.org/formats/oboInOwl#source) "skos:narrowMatch"
+- [rhombomere 1](http://purl.obolibrary.org/obo/UBERON_0005499) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Hindbrain segment or neuromere 1."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ZFA:0001031"
-- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "protein phosphokinase activity"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "EC:2.7.11.1"
+- [rhombomere 1](http://purl.obolibrary.org/obo/UBERON_0005499) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ZFA:0001031"
-- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "protein kinase (phosphorylating) activity"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "EC:2.7.11.1"
+- [rhombomere 1](http://purl.obolibrary.org/obo/UBERON_0005499) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [vertebrate_core](http://purl.obolibrary.org/obo/uberon/core#vertebrate_core)
-#### Added
-- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "EC:2.7.11.1"
- - [source](http://www.geneontology.org/formats/oboInOwl#source) "skos:exactMatch"
+- [rhombomere 1](http://purl.obolibrary.org/obo/UBERON_0005499) [id](http://www.geneontology.org/formats/oboInOwl#id) "UBERON:0005499"
+- [rhombomere 1](http://purl.obolibrary.org/obo/UBERON_0005499) [label](http://www.w3.org/2000/01/rdf-schema#label) "rhombomere 1"
-### protein tyrosine kinase activity `http://purl.obolibrary.org/obo/GO_0004713`
+- Class: [rhombomere 1](http://purl.obolibrary.org/obo/UBERON_0005499)
-#### Added
-- [protein tyrosine kinase activity](http://purl.obolibrary.org/obo/GO_0004713) SubClassOf [has participant](http://purl.obolibrary.org/obo/RO_0000057) some [CHEBI_30616](http://purl.obolibrary.org/obo/CHEBI_30616)
+- [rhombomere 1](http://purl.obolibrary.org/obo/UBERON_0005499) SubClassOf [rhombomere](http://purl.obolibrary.org/obo/UBERON_0001892)
-- [protein tyrosine kinase activity](http://purl.obolibrary.org/obo/GO_0004713) SubClassOf [has participant](http://purl.obolibrary.org/obo/RO_0000057) some [CHEBI_82620](http://purl.obolibrary.org/obo/CHEBI_82620)
+- [rhombomere 1](http://purl.obolibrary.org/obo/UBERON_0005499) SubClassOf [develops from](http://purl.obolibrary.org/obo/RO_0002202) some [presumptive rhombomere 1](http://purl.obolibrary.org/obo/UBERON_0007289)
+ - [evidence](http://www.geneontology.org/formats/oboInOwl#evidence) "definitional"
-- [protein tyrosine kinase activity](http://purl.obolibrary.org/obo/GO_0004713) SubClassOf [has participant](http://purl.obolibrary.org/obo/RO_0000057) some [CHEBI_456216](http://purl.obolibrary.org/obo/CHEBI_456216)
-- [protein tyrosine kinase activity](http://purl.obolibrary.org/obo/GO_0004713) SubClassOf [has participant](http://purl.obolibrary.org/obo/RO_0000057) some [CHEBI_15378](http://purl.obolibrary.org/obo/CHEBI_15378)
+### rhombomere 1 development `http://purl.obolibrary.org/obo/GO_0021567`
-- [protein tyrosine kinase activity](http://purl.obolibrary.org/obo/GO_0004713) SubClassOf [has participant](http://purl.obolibrary.org/obo/RO_0000057) some [CHEBI_46858](http://purl.obolibrary.org/obo/CHEBI_46858)
+#### Added
+- [rhombomere 1 development](http://purl.obolibrary.org/obo/GO_0021567) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0021567"
+- [rhombomere 1 development](http://purl.obolibrary.org/obo/GO_0021567) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The process whose specific outcome is the progression of rhombomere 1 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dph"
-### protein-phosphatidylethanolamide deconjugating activity `http://purl.obolibrary.org/obo/GO_0019786`
-#### Removed
-- [protein-phosphatidylethanolamide deconjugating activity](http://purl.obolibrary.org/obo/GO_0019786) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "Atg8-specific protease activity"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:jid"
-- [protein-phosphatidylethanolamide deconjugating activity](http://purl.obolibrary.org/obo/GO_0019786) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "APG8-specific protease activity"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:vw"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:curators"
-- [protein-phosphatidylethanolamide deconjugating activity](http://purl.obolibrary.org/obo/GO_0019786) [label](http://www.w3.org/2000/01/rdf-schema#label) "Atg8-specific peptidase activity"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GO_REF:0000021"
-- [protein-phosphatidylethanolamide deconjugating activity](http://purl.obolibrary.org/obo/GO_0019786) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A thiol-dependent isopeptidase activity that cleaves APG8 from a target protein to which it is conjugated."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:mah"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dgh"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:28901328"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:cls"
-- [protein-phosphatidylethanolamide deconjugating activity](http://purl.obolibrary.org/obo/GO_0019786) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "APG8-PE hydrolase"
+- [rhombomere 1 development](http://purl.obolibrary.org/obo/GO_0021567) [label](http://www.w3.org/2000/01/rdf-schema#label) "rhombomere 1 development"
-- [protein-phosphatidylethanolamide deconjugating activity](http://purl.obolibrary.org/obo/GO_0019786) SubClassOf [ubiquitin-like protein peptidase activity](http://purl.obolibrary.org/obo/GO_0019783)
+- [rhombomere 1 development](http://purl.obolibrary.org/obo/GO_0021567) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process"
-- [protein-phosphatidylethanolamide deconjugating activity](http://purl.obolibrary.org/obo/GO_0019786) SubClassOf [cysteine-type peptidase activity](http://purl.obolibrary.org/obo/GO_0008234)
+- Class: [rhombomere 1 development](http://purl.obolibrary.org/obo/GO_0021567)
-#### Added
-- [protein-phosphatidylethanolamide deconjugating activity](http://purl.obolibrary.org/obo/GO_0019786) [label](http://www.w3.org/2000/01/rdf-schema#label) "protein-phosphatidylethanolamide deconjugating activity"
+- [rhombomere 1 development](http://purl.obolibrary.org/obo/GO_0021567) EquivalentTo [anatomical structure development](http://purl.obolibrary.org/obo/GO_0048856) and ([results in development of](http://purl.obolibrary.org/obo/RO_0002296) some [rhombomere 1](http://purl.obolibrary.org/obo/UBERON_0005499))
-- [protein-phosphatidylethanolamide deconjugating activity](http://purl.obolibrary.org/obo/GO_0019786) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "ATG8-PE deconjugation activity"
- - [source](http://www.geneontology.org/formats/oboInOwl#source) "skos:narrowMatch"
+- [rhombomere 1 development](http://purl.obolibrary.org/obo/GO_0021567) SubClassOf [results in development of](http://purl.obolibrary.org/obo/RO_0002296) some [rhombomere 1](http://purl.obolibrary.org/obo/UBERON_0005499)
-- [protein-phosphatidylethanolamide deconjugating activity](http://purl.obolibrary.org/obo/GO_0019786) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Catalysis of the reaction: [protein]-C-terminal L-amino acid-glycyl-phosphatidylethanolamide + H2O = [protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine. An example of this reaction is the removal of ATG8 from membranes to which it is covalently linked to a phosphatidylethanolamid via its terminal glycine residue."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:28330855"
+- [rhombomere 1 development](http://purl.obolibrary.org/obo/GO_0021567) SubClassOf [rhombomere development](http://purl.obolibrary.org/obo/GO_0021546)
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:22240591"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:2882172"
+### rhombomere 1 formation `http://purl.obolibrary.org/obo/GO_0021652`
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:22652539"
+#### Added
+- [rhombomere 1 formation](http://purl.obolibrary.org/obo/GO_0021652) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0021652"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:28901328"
+- [rhombomere 1 formation](http://purl.obolibrary.org/obo/GO_0021652) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The process that gives rise to rhombomere 1. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dph"
-- [protein-phosphatidylethanolamide deconjugating activity](http://purl.obolibrary.org/obo/GO_0019786) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "APG8-specific protease activity"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:vw"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:jid"
-- [protein-phosphatidylethanolamide deconjugating activity](http://purl.obolibrary.org/obo/GO_0019786) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "Atg8-specific protease activity"
- - [source](http://www.geneontology.org/formats/oboInOwl#source) "skos:narrowMatch"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:curators"
-- [protein-phosphatidylethanolamide deconjugating activity](http://purl.obolibrary.org/obo/GO_0019786) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "ATG8-PE hydrolase activity"
- - [source](http://www.geneontology.org/formats/oboInOwl#source) "skos:narrowMatch"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GO_REF:0000021"
-- [protein-phosphatidylethanolamide deconjugating activity](http://purl.obolibrary.org/obo/GO_0019786) [term tracker item](http://purl.obolibrary.org/obo/IAO_0000233) "https://github.com/geneontology/go-ontology/issues/25472"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI)
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dgh"
-- [protein-phosphatidylethanolamide deconjugating activity](http://purl.obolibrary.org/obo/GO_0019786) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "APG8-PE hydrolase"
- - [source](http://www.geneontology.org/formats/oboInOwl#source) "skos:narrowMatch"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:cls"
-- [protein-phosphatidylethanolamide deconjugating activity](http://purl.obolibrary.org/obo/GO_0019786) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "Atg8-specific peptidase activity"
- - [source](http://www.geneontology.org/formats/oboInOwl#source) "skos:narrowMatch"
+- [rhombomere 1 formation](http://purl.obolibrary.org/obo/GO_0021652) [label](http://www.w3.org/2000/01/rdf-schema#label) "rhombomere 1 formation"
-- [protein-phosphatidylethanolamide deconjugating activity](http://purl.obolibrary.org/obo/GO_0019786) SubClassOf [hydrolase activity](http://purl.obolibrary.org/obo/GO_0016787)
+- [rhombomere 1 formation](http://purl.obolibrary.org/obo/GO_0021652) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process"
-- [protein-phosphatidylethanolamide deconjugating activity](http://purl.obolibrary.org/obo/GO_0019786) SubClassOf [catalytic activity, acting on a protein](http://purl.obolibrary.org/obo/GO_0140096)
+- Class: [rhombomere 1 formation](http://purl.obolibrary.org/obo/GO_0021652)
+- [rhombomere 1 formation](http://purl.obolibrary.org/obo/GO_0021652) EquivalentTo [anatomical structure formation involved in morphogenesis](http://purl.obolibrary.org/obo/GO_0048646) and ([results in formation of](http://purl.obolibrary.org/obo/RO_0002297) some [rhombomere 1](http://purl.obolibrary.org/obo/UBERON_0005499))
-### pulmonary artery `http://purl.obolibrary.org/obo/UBERON_0002012`
-#### Removed
-- [pulmonary artery](http://purl.obolibrary.org/obo/UBERON_0002012) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [human_reference_atlas](http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas)
+- [rhombomere 1 formation](http://purl.obolibrary.org/obo/GO_0021652) SubClassOf [results in formation of](http://purl.obolibrary.org/obo/RO_0002297) some [rhombomere 1](http://purl.obolibrary.org/obo/UBERON_0005499)
-- [pulmonary artery](http://purl.obolibrary.org/obo/UBERON_0002012) [present_in_taxon](http://purl.obolibrary.org/obo/RO_0002175) [Homo sapiens](http://purl.obolibrary.org/obo/NCBITaxon_9606)
+- [rhombomere 1 formation](http://purl.obolibrary.org/obo/GO_0021652) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [rhombomere 1 morphogenesis](http://purl.obolibrary.org/obo/GO_0021651)
+- [rhombomere 1 formation](http://purl.obolibrary.org/obo/GO_0021652) SubClassOf [rhombomere formation](http://purl.obolibrary.org/obo/GO_0021594)
-### pulmonary capillary `http://purl.obolibrary.org/obo/UBERON_0016405`
+### rhombomere 1 lateral wall `http://purl.obolibrary.org/obo/UBERON_0005567`
#### Added
-- [pulmonary capillary](http://purl.obolibrary.org/obo/UBERON_0016405) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [human_reference_atlas](http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas)
+- [rhombomere 1 lateral wall](http://purl.obolibrary.org/obo/UBERON_0005567) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "lateral wall rhombomere 1"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ZFA:0000781"
-- [pulmonary capillary](http://purl.obolibrary.org/obo/UBERON_0016405) [present_in_taxon](http://purl.obolibrary.org/obo/RO_0002175) [Homo sapiens](http://purl.obolibrary.org/obo/NCBITaxon_9606)
+- [rhombomere 1 lateral wall](http://purl.obolibrary.org/obo/UBERON_0005567) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "uberon"
+- [rhombomere 1 lateral wall](http://purl.obolibrary.org/obo/UBERON_0005567) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A rhombomere lateral wall that is part of a rhombomere 1."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "OBOL:automatic"
-### pulmonary vascular system `http://purl.obolibrary.org/obo/UBERON_0008886`
-#### Removed
-- [pulmonary vascular system](http://purl.obolibrary.org/obo/UBERON_0008886) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [human_reference_atlas](http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas)
+- [rhombomere 1 lateral wall](http://purl.obolibrary.org/obo/UBERON_0005567) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ZFA:0000781"
-- [pulmonary vascular system](http://purl.obolibrary.org/obo/UBERON_0008886) [present_in_taxon](http://purl.obolibrary.org/obo/RO_0002175) [Homo sapiens](http://purl.obolibrary.org/obo/NCBITaxon_9606)
+- [rhombomere 1 lateral wall](http://purl.obolibrary.org/obo/UBERON_0005567) [label](http://www.w3.org/2000/01/rdf-schema#label) "rhombomere 1 lateral wall"
+- [rhombomere 1 lateral wall](http://purl.obolibrary.org/obo/UBERON_0005567) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "EHDAA2:0001641"
+- [rhombomere 1 lateral wall](http://purl.obolibrary.org/obo/UBERON_0005567) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [vertebrate_core](http://purl.obolibrary.org/obo/uberon/core#vertebrate_core)
-### putamen `http://purl.obolibrary.org/obo/UBERON_0001874`
+- [rhombomere 1 lateral wall](http://purl.obolibrary.org/obo/UBERON_0005567) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "TAO:0000781"
-#### Added
-- [putamen](http://purl.obolibrary.org/obo/UBERON_0001874) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "DHBA:10338"
+- [rhombomere 1 lateral wall](http://purl.obolibrary.org/obo/UBERON_0005567) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "EMAPA:16482"
-- [putamen](http://purl.obolibrary.org/obo/UBERON_0001874) [UBPROP_0000003](http://purl.obolibrary.org/obo/UBPROP_0000003) "All nuclei of the mammalian basal ganglia are also present in the oldest vertebrates.[well established][VHOG]"
- - [external_class](http://www.geneontology.org/formats/oboInOwl#external_class) "VHOG:0001456"
+- [rhombomere 1 lateral wall](http://purl.obolibrary.org/obo/UBERON_0005567) [id](http://www.geneontology.org/formats/oboInOwl#id) "UBERON:0005567"
- - [source](http://www.geneontology.org/formats/oboInOwl#source) "http://bgee.unil.ch/"
+- Class: [rhombomere 1 lateral wall](http://purl.obolibrary.org/obo/UBERON_0005567)
- - [ontology](http://www.geneontology.org/formats/oboInOwl#ontology) "VHOG"
+- [rhombomere 1 lateral wall](http://purl.obolibrary.org/obo/UBERON_0005567) EquivalentTo [rhombomere lateral wall](http://purl.obolibrary.org/obo/UBERON_0005501) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [rhombomere 1](http://purl.obolibrary.org/obo/UBERON_0005499))
- - [source](http://www.geneontology.org/formats/oboInOwl#source) "DOI:10.1016/j.cub.2011.05.001 Stephenson-Jones M, Samuelsson E, Ericsson J, Robertson B, Grillner S, Evolutionary conservation of the basal ganglia as a common vertebrate mechanism for action selection. Current Biology (2011)"
+- [rhombomere 1 lateral wall](http://purl.obolibrary.org/obo/UBERON_0005567) SubClassOf [rhombomere lateral wall](http://purl.obolibrary.org/obo/UBERON_0005501)
- - [date_retrieved](http://www.geneontology.org/formats/oboInOwl#date_retrieved) "2012-09-17"
+- [rhombomere 1 lateral wall](http://purl.obolibrary.org/obo/UBERON_0005567) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [rhombomere 1](http://purl.obolibrary.org/obo/UBERON_0005499)
-- [putamen](http://purl.obolibrary.org/obo/UBERON_0001874) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [pheno_slim](http://purl.obolibrary.org/obo/uberon/core#pheno_slim)
-- [putamen](http://purl.obolibrary.org/obo/UBERON_0001874) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GAID:671"
+### rhombomere 1 morphogenesis `http://purl.obolibrary.org/obo/GO_0021651`
-- [putamen](http://purl.obolibrary.org/obo/UBERON_0001874) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "HBA:4287"
+#### Added
+- [rhombomere 1 morphogenesis](http://purl.obolibrary.org/obo/GO_0021651) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process"
+
+- [rhombomere 1 morphogenesis](http://purl.obolibrary.org/obo/GO_0021651) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The process in which the anatomical structure of rhombomere 1 is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dph"
-- [putamen](http://purl.obolibrary.org/obo/UBERON_0001874) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "EMAPA:35719"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:jid"
-- [putamen](http://purl.obolibrary.org/obo/UBERON_0001874) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "MESH:D011699"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:curators"
-- [putamen](http://purl.obolibrary.org/obo/UBERON_0001874) [editor note](http://purl.obolibrary.org/obo/IAO_0000116) "check - rodents. The caudate nucleus and putamen are separated by a clear white matter bundle in most species but not in rodents (MM)"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GO_REF:0000021"
-- [putamen](http://purl.obolibrary.org/obo/UBERON_0001874) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "VHOG:0001456"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dgh"
-- [putamen](http://purl.obolibrary.org/obo/UBERON_0001874) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "nucleus putamen"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:cls"
-- [putamen](http://purl.obolibrary.org/obo/UBERON_0001874) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "BAMS:PU"
+- [rhombomere 1 morphogenesis](http://purl.obolibrary.org/obo/GO_0021651) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0021651"
-- [putamen](http://purl.obolibrary.org/obo/UBERON_0001874) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "CALOHA:TS-2041"
+- [rhombomere 1 morphogenesis](http://purl.obolibrary.org/obo/GO_0021651) [label](http://www.w3.org/2000/01/rdf-schema#label) "rhombomere 1 morphogenesis"
-- [putamen](http://purl.obolibrary.org/obo/UBERON_0001874) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "uberon"
+- Class: [rhombomere 1 morphogenesis](http://purl.obolibrary.org/obo/GO_0021651)
-- [putamen](http://purl.obolibrary.org/obo/UBERON_0001874) [label](http://www.w3.org/2000/01/rdf-schema#label) "putamen"
+- [rhombomere 1 morphogenesis](http://purl.obolibrary.org/obo/GO_0021651) EquivalentTo [anatomical structure morphogenesis](http://purl.obolibrary.org/obo/GO_0009653) and ([results in morphogenesis of](http://purl.obolibrary.org/obo/RO_0002298) some [rhombomere 1](http://purl.obolibrary.org/obo/UBERON_0005499))
-- [putamen](http://purl.obolibrary.org/obo/UBERON_0001874) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [uberon_slim](http://purl.obolibrary.org/obo/uberon/core#uberon_slim)
+- [rhombomere 1 morphogenesis](http://purl.obolibrary.org/obo/GO_0021651) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [rhombomere 1 development](http://purl.obolibrary.org/obo/GO_0021567)
-- [putamen](http://purl.obolibrary.org/obo/UBERON_0001874) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "BAMS:Pu"
+- [rhombomere 1 morphogenesis](http://purl.obolibrary.org/obo/GO_0021651) SubClassOf [results in morphogenesis of](http://purl.obolibrary.org/obo/RO_0002298) some [rhombomere 1](http://purl.obolibrary.org/obo/UBERON_0005499)
-- [putamen](http://purl.obolibrary.org/obo/UBERON_0001874) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "MA:0000895"
+- [rhombomere 1 morphogenesis](http://purl.obolibrary.org/obo/GO_0021651) SubClassOf [rhombomere morphogenesis](http://purl.obolibrary.org/obo/GO_0021593)
-- [putamen](http://purl.obolibrary.org/obo/UBERON_0001874) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "FMA:61834"
-- [putamen](http://purl.obolibrary.org/obo/UBERON_0001874) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "BM:Tel-Pu"
+### runt-related transcription factor 1 `http://purl.obolibrary.org/obo/PR_000014362`
-- [putamen](http://purl.obolibrary.org/obo/UBERON_0001874) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "UMLS:C0034169"
- - [source](http://www.geneontology.org/formats/oboInOwl#source) "ncithesaurus:Putamen"
+#### Added
+- [runt-related transcription factor 1](http://purl.obolibrary.org/obo/PR_000014362) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [runt-related transcription factor 1 (human)](http://purl.obolibrary.org/obo/PR_Q01196)
-- [putamen](http://purl.obolibrary.org/obo/UBERON_0001874) [present_in_taxon](http://purl.obolibrary.org/obo/RO_0002175) [Homo sapiens](http://purl.obolibrary.org/obo/NCBITaxon_9606)
-- [putamen](http://purl.obolibrary.org/obo/UBERON_0001874) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Subcortical nucleus of telencephalic , which together with the caudate nucleus, forms the striatum. The putamen lies lateral to the internal capsule and medial to the external medullary lamina, and is separated from the caudate nucleus by the fibers of the internal capsule for most of its length, except at its anterior portion."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "BIRNLEX:809"
+### scalp `http://purl.obolibrary.org/obo/UBERON_0000403`
+#### Removed
+- [scalp](http://purl.obolibrary.org/obo/UBERON_0000403) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [putamen](http://purl.obolibrary.org/obo/UBERON_0001874) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "BIRNLEX:809"
-- [putamen](http://purl.obolibrary.org/obo/UBERON_0001874) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "neuronames:230"
- - [source](http://www.geneontology.org/formats/oboInOwl#source) "BIRNLEX:809"
-- [putamen](http://purl.obolibrary.org/obo/UBERON_0001874) [id](http://www.geneontology.org/formats/oboInOwl#id) "UBERON:0001874"
+### scavenger receptor cysteine-rich type 1 protein M130 `http://purl.obolibrary.org/obo/PR_000001925`
-- [putamen](http://purl.obolibrary.org/obo/UBERON_0001874) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "EV:0100187"
+#### Added
+- [scavenger receptor cysteine-rich type 1 protein M130](http://purl.obolibrary.org/obo/PR_000001925) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [scavenger receptor cysteine-rich type 1 protein M130 (human)](http://purl.obolibrary.org/obo/PR_Q86VB7)
-- [putamen](http://purl.obolibrary.org/obo/UBERON_0001874) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "NCIT:C12452"
-- [putamen](http://purl.obolibrary.org/obo/UBERON_0001874) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "DMBA:15857"
+### sciatic nerve `http://purl.obolibrary.org/obo/UBERON_0001322`
+#### Removed
+- [sciatic nerve](http://purl.obolibrary.org/obo/UBERON_0001322) SubClassOf [neuron projection bundle](http://purl.obolibrary.org/obo/CARO_0001001)
-- [putamen](http://purl.obolibrary.org/obo/UBERON_0001874) [UBPROP_0000001](http://purl.obolibrary.org/obo/UBPROP_0000001) "Nucleus of brain which lies ventral to the caudate nucleus and internal capsule and medial to the external capsule. The putamen and caudate nucleus together form the dorsal striatum. It is also one of the structures that comprises the basal ganglia. Through various pathways, the putamen is connected to the substantia nigra and globus pallidus. The main function of the putamen is to regulate movements and influence various types of learning. It employs dopamine to perform its functions. The putamen also plays a role in degenerative neurological disorders, such as Parkinson's disease[Wikipedia:Putamen]."
- - [source](http://www.geneontology.org/formats/oboInOwl#source) "Wikipedia:Putamen"
-- [putamen](http://purl.obolibrary.org/obo/UBERON_0001874) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [human_reference_atlas](http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas)
-- [putamen](http://purl.obolibrary.org/obo/UBERON_0001874) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "SCTID:281512002"
+### sclera `http://purl.obolibrary.org/obo/UBERON_0001773`
+#### Removed
+- [sclera](http://purl.obolibrary.org/obo/UBERON_0001773) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [putamen](http://purl.obolibrary.org/obo/UBERON_0001874) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Wikipedia:Putamen"
-- [putamen](http://purl.obolibrary.org/obo/UBERON_0001874) [depicted by](http://xmlns.com/foaf/0.1/depicted_by) "http://upload.wikimedia.org/wikipedia/commons/3/33/BrainCaudatePutamen.svg"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI)
-- [putamen](http://purl.obolibrary.org/obo/UBERON_0001874) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PBA:10086"
+### scleral cell `http://purl.obolibrary.org/obo/CL_0000347`
+#### Removed
+- [scleral cell](http://purl.obolibrary.org/obo/CL_0000347) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- Class: [putamen](http://purl.obolibrary.org/obo/UBERON_0001874)
-- [putamen](http://purl.obolibrary.org/obo/UBERON_0001874) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [cerebral hemisphere](http://purl.obolibrary.org/obo/UBERON_0001869)
- - [source](http://www.geneontology.org/formats/oboInOwl#source) "FMA"
-- [putamen](http://purl.obolibrary.org/obo/UBERON_0001874) SubClassOf [telencephalic nucleus](http://purl.obolibrary.org/obo/UBERON_0009663)
+### scleral mesenchyme `http://purl.obolibrary.org/obo/UBERON_0010299`
+#### Removed
+- [scleral mesenchyme](http://purl.obolibrary.org/obo/UBERON_0010299) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [putamen](http://purl.obolibrary.org/obo/UBERON_0001874) SubClassOf [contributes to morphology of](http://purl.obolibrary.org/obo/RO_0002433) some [caudate-putamen](http://purl.obolibrary.org/obo/UBERON_0005383)
-- [putamen](http://purl.obolibrary.org/obo/UBERON_0001874) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [caudate-putamen](http://purl.obolibrary.org/obo/UBERON_0005383)
+### secondary lens fiber `http://purl.obolibrary.org/obo/CL_0002225`
+#### Removed
+- [secondary lens fiber](http://purl.obolibrary.org/obo/CL_0002225) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-### putamen development `http://purl.obolibrary.org/obo/GO_0021758`
-#### Added
-- [putamen development](http://purl.obolibrary.org/obo/GO_0021758) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0021758"
-- [putamen development](http://purl.obolibrary.org/obo/GO_0021758) [label](http://www.w3.org/2000/01/rdf-schema#label) "putamen development"
+### secondary motor neuron `http://purl.obolibrary.org/obo/CL_0000536`
+#### Removed
+- [secondary motor neuron](http://purl.obolibrary.org/obo/CL_0000536) [label](http://www.w3.org/2000/01/rdf-schema#label) "secondary motor neuron"
-- [putamen development](http://purl.obolibrary.org/obo/GO_0021758) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process"
+- [secondary motor neuron](http://purl.obolibrary.org/obo/CL_0000536) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "FMA:83620"
-- [putamen development](http://purl.obolibrary.org/obo/GO_0021758) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The progression of the putamen over time from its initial formation until its mature state. The putamen is the lens-shaped basal ganglion involved with control of voluntary movement in the brain."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dph"
+#### Added
+- [secondary motor neuron](http://purl.obolibrary.org/obo/CL_0000536) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A secondary neuron (sensu Teleostei) that has a motor function."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:1842357"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:jid"
+- [secondary motor neuron](http://purl.obolibrary.org/obo/CL_0000536) [label](http://www.w3.org/2000/01/rdf-schema#label) "secondary motor neuron (sensu Teleostei)"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GO_REF:0000021"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dgh"
+### secondary neuron `http://purl.obolibrary.org/obo/CL_0000535`
+#### Removed
+- [secondary neuron](http://purl.obolibrary.org/obo/CL_0000535) [label](http://www.w3.org/2000/01/rdf-schema#label) "secondary neuron"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:cls"
+#### Added
+- [secondary neuron](http://purl.obolibrary.org/obo/CL_0000535) [label](http://www.w3.org/2000/01/rdf-schema#label) "secondary neuron (sensu Teleostei)"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ISBN:0878937420"
+- [secondary neuron](http://purl.obolibrary.org/obo/CL_0000535) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A neuron of teleosts that develops later than a primary neuron, typically during the larval stages."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:1842357"
-- Class: [putamen development](http://purl.obolibrary.org/obo/GO_0021758)
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1242/dev.108.1.121"
-- [putamen development](http://purl.obolibrary.org/obo/GO_0021758) EquivalentTo [anatomical structure development](http://purl.obolibrary.org/obo/GO_0048856) and ([results in development of](http://purl.obolibrary.org/obo/RO_0002296) some [putamen](http://purl.obolibrary.org/obo/UBERON_0001874))
+- [secondary neuron](http://purl.obolibrary.org/obo/CL_0000535) SubClassOf [only in taxon](http://purl.obolibrary.org/obo/RO_0002160) some [Teleostei](http://purl.obolibrary.org/obo/NCBITaxon_32443)
+ - [term tracker item](http://purl.obolibrary.org/obo/IAO_0000233) "https://github.com/obophenotype/cell-ontology/pull/1950"
-- [putamen development](http://purl.obolibrary.org/obo/GO_0021758) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [striatum development](http://purl.obolibrary.org/obo/GO_0021756)
-- [putamen development](http://purl.obolibrary.org/obo/GO_0021758) SubClassOf [results in development of](http://purl.obolibrary.org/obo/RO_0002296) some [putamen](http://purl.obolibrary.org/obo/UBERON_0001874)
+### secondary oocyte `http://purl.obolibrary.org/obo/CL_0000655`
+#### Removed
+- [secondary oocyte](http://purl.obolibrary.org/obo/CL_0000655) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [putamen development](http://purl.obolibrary.org/obo/GO_0021758) SubClassOf [neural nucleus development](http://purl.obolibrary.org/obo/GO_0048857)
-### regulation of ATP biosynthetic process `http://purl.obolibrary.org/obo/GO_2001169`
+### segmental bronchus `http://purl.obolibrary.org/obo/UBERON_0002184`
#### Added
-- [regulation of ATP biosynthetic process](http://purl.obolibrary.org/obo/GO_2001169) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "regulation of ATP regeneration"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:obol"
+- [segmental bronchus](http://purl.obolibrary.org/obo/UBERON_0002184) SubClassOf [has part](http://purl.obolibrary.org/obo/BFO_0000051) some [cartilage of bronchus](http://purl.obolibrary.org/obo/UBERON_0001956)
-- [regulation of ATP biosynthetic process](http://purl.obolibrary.org/obo/GO_2001169) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "kmv"
+- [segmental bronchus](http://purl.obolibrary.org/obo/UBERON_0002184) SubClassOf [has part](http://purl.obolibrary.org/obo/BFO_0000051) some [lung mesenchyme](http://purl.obolibrary.org/obo/UBERON_0004883)
-- [regulation of ATP biosynthetic process](http://purl.obolibrary.org/obo/GO_2001169) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:2001169"
+- [segmental bronchus](http://purl.obolibrary.org/obo/UBERON_0002184) SubClassOf [has part](http://purl.obolibrary.org/obo/BFO_0000051) some [bronchus smooth muscle](http://purl.obolibrary.org/obo/UBERON_0004242)
-- [regulation of ATP biosynthetic process](http://purl.obolibrary.org/obo/GO_2001169) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process"
+- [segmental bronchus](http://purl.obolibrary.org/obo/UBERON_0002184) SubClassOf [has part](http://purl.obolibrary.org/obo/BFO_0000051) some [bronchus submucosal gland](http://purl.obolibrary.org/obo/UBERON_8410043)
-- [regulation of ATP biosynthetic process](http://purl.obolibrary.org/obo/GO_2001169) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that modulates the frequency, rate or extent of ATP biosynthetic process."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:obol"
-- [regulation of ATP biosynthetic process](http://purl.obolibrary.org/obo/GO_2001169) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "regulation of ATP synthesis"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:obol"
+### semen `http://purl.obolibrary.org/obo/UBERON_0001968`
+#### Removed
+- [semen](http://purl.obolibrary.org/obo/UBERON_0001968) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [regulation of ATP biosynthetic process](http://purl.obolibrary.org/obo/GO_2001169) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "regulation of ATP anabolism"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:obol"
-- [regulation of ATP biosynthetic process](http://purl.obolibrary.org/obo/GO_2001169) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "regulation of ATP formation"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:obol"
-- [regulation of ATP biosynthetic process](http://purl.obolibrary.org/obo/GO_2001169) [label](http://www.w3.org/2000/01/rdf-schema#label) "regulation of ATP biosynthetic process"
+### semicircular canal `http://purl.obolibrary.org/obo/UBERON_0001840`
+#### Removed
+- [semicircular canal](http://purl.obolibrary.org/obo/UBERON_0001840) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [regulation of ATP biosynthetic process](http://purl.obolibrary.org/obo/GO_2001169) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "regulation of ATP biosynthesis"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:obol"
-- [regulation of ATP biosynthetic process](http://purl.obolibrary.org/obo/GO_2001169) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2011-10-26T03:18:03Z"
-- Class: [regulation of ATP biosynthetic process](http://purl.obolibrary.org/obo/GO_2001169)
+### sensory neuron of dorsal root ganglion `http://purl.obolibrary.org/obo/CL_1001451`
+#### Removed
+- [sensory neuron of dorsal root ganglion](http://purl.obolibrary.org/obo/CL_1001451) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [regulation of ATP biosynthetic process](http://purl.obolibrary.org/obo/GO_2001169) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([regulates](http://purl.obolibrary.org/obo/RO_0002211) some [ATP biosynthetic process](http://purl.obolibrary.org/obo/GO_0006754))
-- [regulation of ATP biosynthetic process](http://purl.obolibrary.org/obo/GO_2001169) SubClassOf [regulation of ATP metabolic process](http://purl.obolibrary.org/obo/GO_1903578)
-- [regulation of ATP biosynthetic process](http://purl.obolibrary.org/obo/GO_2001169) SubClassOf [regulates](http://purl.obolibrary.org/obo/RO_0002211) some [ATP biosynthetic process](http://purl.obolibrary.org/obo/GO_0006754)
+### sensory neuron of spinal nerve `http://purl.obolibrary.org/obo/CL_0009000`
+#### Removed
+- [sensory neuron of spinal nerve](http://purl.obolibrary.org/obo/CL_0009000) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [regulation of ATP biosynthetic process](http://purl.obolibrary.org/obo/GO_2001169) SubClassOf [regulation of biosynthetic process](http://purl.obolibrary.org/obo/GO_0009889)
-### regulation of ATP metabolic process `http://purl.obolibrary.org/obo/GO_1903578`
+### serous pericardium `http://purl.obolibrary.org/obo/UBERON_0002357`
+#### Removed
+- [serous pericardium](http://purl.obolibrary.org/obo/UBERON_0002357) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000)
-#### Added
-- [regulation of ATP metabolic process](http://purl.obolibrary.org/obo/GO_1903578) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "regulation of ATP metabolism"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie"
-- [regulation of ATP metabolic process](http://purl.obolibrary.org/obo/GO_1903578) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:1903578"
-- [regulation of ATP metabolic process](http://purl.obolibrary.org/obo/GO_1903578) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that modulates the frequency, rate or extent of ATP metabolic process."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:20695849"
+### set of muscles of vertebral column `http://purl.obolibrary.org/obo/UBERON_0004468`
+#### Removed
+- [set of muscles of vertebral column](http://purl.obolibrary.org/obo/UBERON_0004468) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000)
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GO_REF:0000058"
-- [regulation of ATP metabolic process](http://purl.obolibrary.org/obo/GO_1903578) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "sl"
+### shoulder `http://purl.obolibrary.org/obo/UBERON_0001467`
+#### Removed
+- [shoulder](http://purl.obolibrary.org/obo/UBERON_0001467) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [regulation of ATP metabolic process](http://purl.obolibrary.org/obo/GO_1903578) [label](http://www.w3.org/2000/01/rdf-schema#label) "regulation of ATP metabolic process"
-- [regulation of ATP metabolic process](http://purl.obolibrary.org/obo/GO_1903578) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process"
-- [regulation of ATP metabolic process](http://purl.obolibrary.org/obo/GO_1903578) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2014-10-30T19:04:24Z"
+### shoulder connective tissue `http://purl.obolibrary.org/obo/UBERON_0003579`
+#### Removed
+- [shoulder connective tissue](http://purl.obolibrary.org/obo/UBERON_0003579) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- Class: [regulation of ATP metabolic process](http://purl.obolibrary.org/obo/GO_1903578)
-- [regulation of ATP metabolic process](http://purl.obolibrary.org/obo/GO_1903578) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([regulates](http://purl.obolibrary.org/obo/RO_0002211) some [ATP metabolic process](http://purl.obolibrary.org/obo/GO_0046034))
-- [regulation of ATP metabolic process](http://purl.obolibrary.org/obo/GO_1903578) SubClassOf [regulation of metabolic process](http://purl.obolibrary.org/obo/GO_0019222)
+### shoulder joint `http://purl.obolibrary.org/obo/UBERON_0016884`
+#### Removed
+- [shoulder joint](http://purl.obolibrary.org/obo/UBERON_0016884) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [regulation of ATP metabolic process](http://purl.obolibrary.org/obo/GO_1903578) SubClassOf [regulates](http://purl.obolibrary.org/obo/RO_0002211) some [ATP metabolic process](http://purl.obolibrary.org/obo/GO_0046034)
-### regulation of ATP-dependent activity `http://purl.obolibrary.org/obo/GO_0043462`
-#### Removed
-- [regulation of ATP-dependent activity](http://purl.obolibrary.org/obo/GO_0043462) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [term_scheduled_for_obsoletion](http://purl.obolibrary.org/obo/go#term_scheduled_for_obsoletion)
+### sialic acid-binding Ig-like lectin 5 `http://purl.obolibrary.org/obo/PR_000001927`
#### Added
-- [regulation of ATP-dependent activity](http://purl.obolibrary.org/obo/GO_0043462) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate)
+- [sialic acid-binding Ig-like lectin 5](http://purl.obolibrary.org/obo/PR_000001927) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [sialic acid-binding Ig-like lectin 5 (human)](http://purl.obolibrary.org/obo/PR_O15389)
-### regulation of DNA binding `http://purl.obolibrary.org/obo/GO_0051101`
-#### Removed
-- [regulation of DNA binding](http://purl.obolibrary.org/obo/GO_0051101) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [term_scheduled_for_obsoletion](http://purl.obolibrary.org/obo/go#term_scheduled_for_obsoletion)
+### sialic acid-binding Ig-like lectin 6 `http://purl.obolibrary.org/obo/PR_000001928`
#### Added
-- [regulation of DNA binding](http://purl.obolibrary.org/obo/GO_0051101) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate)
+- [sialic acid-binding Ig-like lectin 6](http://purl.obolibrary.org/obo/PR_000001928) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [sialic acid-binding Ig-like lectin 6 (human)](http://purl.obolibrary.org/obo/PR_O43699)
-### regulation of RNA binding `http://purl.obolibrary.org/obo/GO_1905214`
-#### Removed
-- [regulation of RNA binding](http://purl.obolibrary.org/obo/GO_1905214) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [term_scheduled_for_obsoletion](http://purl.obolibrary.org/obo/go#term_scheduled_for_obsoletion)
+### sialoadhesin `http://purl.obolibrary.org/obo/PR_000001931`
#### Added
-- [regulation of RNA binding](http://purl.obolibrary.org/obo/GO_1905214) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate)
+- [sialoadhesin](http://purl.obolibrary.org/obo/PR_000001931) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [sialoadhesin (human)](http://purl.obolibrary.org/obo/PR_Q9BZZ2)
-### regulation of acetylcholine-gated cation channel activity `http://purl.obolibrary.org/obo/GO_1903048`
+### sigmoid colon `http://purl.obolibrary.org/obo/UBERON_0001159`
#### Removed
-- [regulation of acetylcholine-gated cation channel activity](http://purl.obolibrary.org/obo/GO_1903048) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [term_scheduled_for_obsoletion](http://purl.obolibrary.org/obo/go#term_scheduled_for_obsoletion)
+- [sigmoid colon](http://purl.obolibrary.org/obo/UBERON_0001159) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-#### Added
-- [regulation of acetylcholine-gated cation channel activity](http://purl.obolibrary.org/obo/GO_1903048) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate)
-### regulation of binding `http://purl.obolibrary.org/obo/GO_0051098`
-#### Removed
-- [regulation of binding](http://purl.obolibrary.org/obo/GO_0051098) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [term_scheduled_for_obsoletion](http://purl.obolibrary.org/obo/go#term_scheduled_for_obsoletion)
+### signal transducer CD24 `http://purl.obolibrary.org/obo/PR_000001932`
#### Added
-- [regulation of binding](http://purl.obolibrary.org/obo/GO_0051098) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate)
+- [signal transducer CD24](http://purl.obolibrary.org/obo/PR_000001932) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [signal transducer CD24 (human)](http://purl.obolibrary.org/obo/PR_P25063)
-### regulation of calcium ion binding `http://purl.obolibrary.org/obo/GO_1901876`
-#### Removed
-- [regulation of calcium ion binding](http://purl.obolibrary.org/obo/GO_1901876) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [term_scheduled_for_obsoletion](http://purl.obolibrary.org/obo/go#term_scheduled_for_obsoletion)
+### simultaneous with `http://purl.obolibrary.org/obo/RO_0002082`
#### Added
-- [regulation of calcium ion binding](http://purl.obolibrary.org/obo/GO_1901876) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate)
+- [simultaneous with](http://purl.obolibrary.org/obo/RO_0002082) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "x simultaneous with y iff ω(x) = ω(y) and ω(α ) = ω(α), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point and '=' indicates the same instance in time."
+- Symmetric: [simultaneous with](http://purl.obolibrary.org/obo/RO_0002082)
-### regulation of calcium ion transmembrane transporter activity `http://purl.obolibrary.org/obo/GO_1901019`
+
+### skeletal musculature `http://purl.obolibrary.org/obo/UBERON_0018254`
#### Removed
-- [regulation of calcium ion transmembrane transporter activity](http://purl.obolibrary.org/obo/GO_1901019) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [term_scheduled_for_obsoletion](http://purl.obolibrary.org/obo/go#term_scheduled_for_obsoletion)
+- [skeletal musculature](http://purl.obolibrary.org/obo/UBERON_0018254) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-#### Added
-- [regulation of calcium ion transmembrane transporter activity](http://purl.obolibrary.org/obo/GO_1901019) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate)
-### regulation of catalytic activity `http://purl.obolibrary.org/obo/GO_0050790`
+### skeletal musculature of head `http://purl.obolibrary.org/obo/UBERON_0004461`
#### Removed
-- [regulation of catalytic activity](http://purl.obolibrary.org/obo/GO_0050790) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [term_scheduled_for_obsoletion](http://purl.obolibrary.org/obo/go#term_scheduled_for_obsoletion)
+- [skeletal musculature of head](http://purl.obolibrary.org/obo/UBERON_0004461) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000)
-#### Added
-- [regulation of catalytic activity](http://purl.obolibrary.org/obo/GO_0050790) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate)
-### regulation of cation channel activity `http://purl.obolibrary.org/obo/GO_2001257`
+### skeletal tissue `http://purl.obolibrary.org/obo/UBERON_0004755`
#### Removed
-- [regulation of cation channel activity](http://purl.obolibrary.org/obo/GO_2001257) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [term_scheduled_for_obsoletion](http://purl.obolibrary.org/obo/go#term_scheduled_for_obsoletion)
+- [skeletal tissue](http://purl.obolibrary.org/obo/UBERON_0004755) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-#### Added
-- [regulation of cation channel activity](http://purl.obolibrary.org/obo/GO_2001257) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate)
-### regulation of chromatin binding `http://purl.obolibrary.org/obo/GO_0035561`
+### skeleton of `http://purl.obolibrary.org/obo/RO_0002576`
#### Removed
-- [regulation of chromatin binding](http://purl.obolibrary.org/obo/GO_0035561) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [term_scheduled_for_obsoletion](http://purl.obolibrary.org/obo/go#term_scheduled_for_obsoletion)
+- [skeleton of](http://purl.obolibrary.org/obo/RO_0002576) Domain [connected anatomical structure](http://purl.obolibrary.org/obo/CARO_0000003)
+
+- [skeleton of](http://purl.obolibrary.org/obo/RO_0002576) Range [connected anatomical structure](http://purl.obolibrary.org/obo/CARO_0000003)
#### Added
-- [regulation of chromatin binding](http://purl.obolibrary.org/obo/GO_0035561) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate)
+- [skeleton of](http://purl.obolibrary.org/obo/RO_0002576) Domain [anatomical structure](http://purl.obolibrary.org/obo/UBERON_0000061)
+
+- [skeleton of](http://purl.obolibrary.org/obo/RO_0002576) Range [anatomical structure](http://purl.obolibrary.org/obo/UBERON_0000061)
-### regulation of collagen binding `http://purl.obolibrary.org/obo/GO_0033341`
+### skeleton of digitopodium `http://purl.obolibrary.org/obo/UBERON_0012150`
#### Removed
-- [regulation of collagen binding](http://purl.obolibrary.org/obo/GO_0033341) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [term_scheduled_for_obsoletion](http://purl.obolibrary.org/obo/go#term_scheduled_for_obsoletion)
+- [skeleton of digitopodium](http://purl.obolibrary.org/obo/UBERON_0012150) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000)
-#### Added
-- [regulation of collagen binding](http://purl.obolibrary.org/obo/GO_0033341) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate)
-### regulation of deoxyribonuclease activity `http://purl.obolibrary.org/obo/GO_0032070`
+### skeleton of lower jaw `http://purl.obolibrary.org/obo/UBERON_0003278`
#### Removed
-- [regulation of deoxyribonuclease activity](http://purl.obolibrary.org/obo/GO_0032070) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [term_scheduled_for_obsoletion](http://purl.obolibrary.org/obo/go#term_scheduled_for_obsoletion)
+- [skeleton of lower jaw](http://purl.obolibrary.org/obo/UBERON_0003278) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000)
-#### Added
-- [regulation of deoxyribonuclease activity](http://purl.obolibrary.org/obo/GO_0032070) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate)
-### regulation of euchromatin binding `http://purl.obolibrary.org/obo/GO_1904793`
+### skeleton of pectoral complex `http://purl.obolibrary.org/obo/UBERON_0012475`
#### Removed
-- [regulation of euchromatin binding](http://purl.obolibrary.org/obo/GO_1904793) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [term_scheduled_for_obsoletion](http://purl.obolibrary.org/obo/go#term_scheduled_for_obsoletion)
+- [skeleton of pectoral complex](http://purl.obolibrary.org/obo/UBERON_0012475) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000)
-#### Added
-- [regulation of euchromatin binding](http://purl.obolibrary.org/obo/GO_1904793) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate)
-### regulation of hydrolase activity `http://purl.obolibrary.org/obo/GO_0051336`
+### skeleton of pelvic complex `http://purl.obolibrary.org/obo/UBERON_0012476`
#### Removed
-- [regulation of hydrolase activity](http://purl.obolibrary.org/obo/GO_0051336) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [term_scheduled_for_obsoletion](http://purl.obolibrary.org/obo/go#term_scheduled_for_obsoletion)
+- [skeleton of pelvic complex](http://purl.obolibrary.org/obo/UBERON_0012476) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000)
-#### Added
-- [regulation of hydrolase activity](http://purl.obolibrary.org/obo/GO_0051336) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate)
-### regulation of iron ion transmembrane transporter activity `http://purl.obolibrary.org/obo/GO_1904254`
+### skeleton of upper jaw `http://purl.obolibrary.org/obo/UBERON_0003277`
#### Removed
-- [regulation of iron ion transmembrane transporter activity](http://purl.obolibrary.org/obo/GO_1904254) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [term_scheduled_for_obsoletion](http://purl.obolibrary.org/obo/go#term_scheduled_for_obsoletion)
+- [skeleton of upper jaw](http://purl.obolibrary.org/obo/UBERON_0003277) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000)
-#### Added
-- [regulation of iron ion transmembrane transporter activity](http://purl.obolibrary.org/obo/GO_1904254) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate)
-### regulation of kinase activity `http://purl.obolibrary.org/obo/GO_0043549`
+### skin appendage follicle `http://purl.obolibrary.org/obo/UBERON_0036150`
#### Removed
-- [regulation of kinase activity](http://purl.obolibrary.org/obo/GO_0043549) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [term_scheduled_for_obsoletion](http://purl.obolibrary.org/obo/go#term_scheduled_for_obsoletion)
+- [skin appendage follicle](http://purl.obolibrary.org/obo/UBERON_0036150) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-#### Added
-- [regulation of kinase activity](http://purl.obolibrary.org/obo/GO_0043549) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate)
-### regulation of ligase activity `http://purl.obolibrary.org/obo/GO_0051340`
+### skin bony tubercle `http://purl.obolibrary.org/obo/UBERON_0017163`
#### Removed
-- [regulation of ligase activity](http://purl.obolibrary.org/obo/GO_0051340) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [term_scheduled_for_obsoletion](http://purl.obolibrary.org/obo/go#term_scheduled_for_obsoletion)
+- [skin bony tubercle](http://purl.obolibrary.org/obo/UBERON_0017163) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-#### Added
-- [regulation of ligase activity](http://purl.obolibrary.org/obo/GO_0051340) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate)
-### regulation of lipid binding `http://purl.obolibrary.org/obo/GO_1900130`
+### smooth muscle cell derived foam cell `http://purl.obolibrary.org/obo/CL_0000892`
#### Removed
-- [regulation of lipid binding](http://purl.obolibrary.org/obo/GO_1900130) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [term_scheduled_for_obsoletion](http://purl.obolibrary.org/obo/go#term_scheduled_for_obsoletion)
+- [smooth muscle cell derived foam cell](http://purl.obolibrary.org/obo/CL_0000892) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-#### Added
-- [regulation of lipid binding](http://purl.obolibrary.org/obo/GO_1900130) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate)
-### regulation of lipid transporter activity `http://purl.obolibrary.org/obo/GO_0110112`
-#### Removed
-- [regulation of lipid transporter activity](http://purl.obolibrary.org/obo/GO_0110112) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [term_scheduled_for_obsoletion](http://purl.obolibrary.org/obo/go#term_scheduled_for_obsoletion)
+### sncg GABAergic cortical interneuron `http://purl.obolibrary.org/obo/CL_4023015`
#### Added
-- [regulation of lipid transporter activity](http://purl.obolibrary.org/obo/GO_0110112) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate)
+- [sncg GABAergic cortical interneuron](http://purl.obolibrary.org/obo/CL_4023015) [symbol](http://purl.obolibrary.org/obo/IAO_0000028) "sncg cortical interneuron"
-### regulation of microtubule binding `http://purl.obolibrary.org/obo/GO_1904526`
-#### Removed
-- [regulation of microtubule binding](http://purl.obolibrary.org/obo/GO_1904526) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [term_scheduled_for_obsoletion](http://purl.obolibrary.org/obo/go#term_scheduled_for_obsoletion)
+### somatostatin `http://purl.obolibrary.org/obo/PR_000015665`
#### Added
-- [regulation of microtubule binding](http://purl.obolibrary.org/obo/GO_1904526) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate)
+- [somatostatin](http://purl.obolibrary.org/obo/PR_000015665) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [somatostatin (human)](http://purl.obolibrary.org/obo/PR_P61278)
-### regulation of molecular function `http://purl.obolibrary.org/obo/GO_0065009`
+### somite `http://purl.obolibrary.org/obo/UBERON_0002329`
#### Removed
-- [regulation of molecular function](http://purl.obolibrary.org/obo/GO_0065009) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [term_scheduled_for_obsoletion](http://purl.obolibrary.org/obo/go#term_scheduled_for_obsoletion)
+- [somite](http://purl.obolibrary.org/obo/UBERON_0002329) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-### regulation of monoatomic ion transmembrane transporter activity `http://purl.obolibrary.org/obo/GO_0032412`
-#### Removed
-- [regulation of monoatomic ion transmembrane transporter activity](http://purl.obolibrary.org/obo/GO_0032412) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [term_scheduled_for_obsoletion](http://purl.obolibrary.org/obo/go#term_scheduled_for_obsoletion)
+### sonic hedgehog protein `http://purl.obolibrary.org/obo/PR_000014841`
#### Added
-- [regulation of monoatomic ion transmembrane transporter activity](http://purl.obolibrary.org/obo/GO_0032412) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate)
+- [sonic hedgehog protein](http://purl.obolibrary.org/obo/PR_000014841) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [sonic hedgehog protein (human)](http://purl.obolibrary.org/obo/PR_Q15465)
-### regulation of neurotransmitter levels `http://purl.obolibrary.org/obo/GO_0001505`
+### specifically dependent continuant `http://purl.obolibrary.org/obo/BFO_0000020`
+#### Removed
+- [specifically dependent continuant](http://purl.obolibrary.org/obo/BFO_0000020) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A continuant that inheres in or is borne by other entities. Every instance of A requires some specific instance of B which must always be the same."@en
#### Added
-- [regulation of neurotransmitter levels](http://purl.obolibrary.org/obo/GO_0001505) SubClassOf [only in taxon](http://purl.obolibrary.org/obo/RO_0002160) some [Eumetazoa](http://purl.obolibrary.org/obo/NCBITaxon_6072)
+- [specifically dependent continuant](http://purl.obolibrary.org/obo/BFO_0000020) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "A continuant that inheres in or is borne by other entities. Every instance of A requires some specific instance of B which must always be the same."@en
-- [regulation of neurotransmitter levels](http://purl.obolibrary.org/obo/GO_0001505) SubClassOf [in taxon](http://purl.obolibrary.org/obo/RO_0002162) only [Eumetazoa](http://purl.obolibrary.org/obo/NCBITaxon_6072)
+- [specifically dependent continuant](http://purl.obolibrary.org/obo/BFO_0000020) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "b is a specifically dependent continuant = Def. b is a continuant & there is some independent continuant c which is not a spatial region and which is such that b s-depends_on c at every time t during the course of b’s existence. (axiom label in BFO2 Reference: [050-003])"@en
-### regulation of neurotransmitter receptor activity `http://purl.obolibrary.org/obo/GO_0099601`
+### sperm `http://purl.obolibrary.org/obo/CL_0000019`
#### Removed
-- [regulation of neurotransmitter receptor activity](http://purl.obolibrary.org/obo/GO_0099601) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [term_scheduled_for_obsoletion](http://purl.obolibrary.org/obo/go#term_scheduled_for_obsoletion)
+- [sperm](http://purl.obolibrary.org/obo/CL_0000019) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-#### Added
-- [regulation of neurotransmitter receptor activity](http://purl.obolibrary.org/obo/GO_0099601) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate)
-### regulation of nuclease activity `http://purl.obolibrary.org/obo/GO_0032069`
+### spermatid `http://purl.obolibrary.org/obo/CL_0000018`
#### Removed
-- [regulation of nuclease activity](http://purl.obolibrary.org/obo/GO_0032069) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [term_scheduled_for_obsoletion](http://purl.obolibrary.org/obo/go#term_scheduled_for_obsoletion)
+- [spermatid](http://purl.obolibrary.org/obo/CL_0000018) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-#### Added
-- [regulation of nuclease activity](http://purl.obolibrary.org/obo/GO_0032069) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate)
-### regulation of peptidase activity `http://purl.obolibrary.org/obo/GO_0052547`
+### spermatocyte `http://purl.obolibrary.org/obo/CL_0000017`
#### Removed
-- [regulation of peptidase activity](http://purl.obolibrary.org/obo/GO_0052547) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [term_scheduled_for_obsoletion](http://purl.obolibrary.org/obo/go#term_scheduled_for_obsoletion)
+- [spermatocyte](http://purl.obolibrary.org/obo/CL_0000017) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [regulation of peptidase activity](http://purl.obolibrary.org/obo/GO_0052547) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process"
-- [regulation of peptidase activity](http://purl.obolibrary.org/obo/GO_0052547) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0052547"
-- [regulation of peptidase activity](http://purl.obolibrary.org/obo/GO_0052547) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that modulates the frequency, rate or extent of peptidase activity, the hydrolysis of peptide bonds within proteins."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:ai"
-
-- [regulation of peptidase activity](http://purl.obolibrary.org/obo/GO_0052547) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "peptidase regulator activity"
+### spinal cord interneuron `http://purl.obolibrary.org/obo/CL_0005000`
+#### Removed
+- [spinal cord interneuron](http://purl.obolibrary.org/obo/CL_0005000) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [regulation of peptidase activity](http://purl.obolibrary.org/obo/GO_0052547) [label](http://www.w3.org/2000/01/rdf-schema#label) "regulation of peptidase activity"
-- Class: [regulation of peptidase activity](http://purl.obolibrary.org/obo/GO_0052547)
-- [regulation of peptidase activity](http://purl.obolibrary.org/obo/GO_0052547) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([regulates](http://purl.obolibrary.org/obo/RO_0002211) some [peptidase activity](http://purl.obolibrary.org/obo/GO_0008233))
+### spinal cord medial motor column neuron `http://purl.obolibrary.org/obo/CL_2000024`
+#### Removed
+- [spinal cord medial motor column neuron](http://purl.obolibrary.org/obo/CL_2000024) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [regulation of peptidase activity](http://purl.obolibrary.org/obo/GO_0052547) SubClassOf [regulates](http://purl.obolibrary.org/obo/RO_0002211) some [peptidase activity](http://purl.obolibrary.org/obo/GO_0008233)
-- [regulation of peptidase activity](http://purl.obolibrary.org/obo/GO_0052547) SubClassOf [regulation of proteolysis](http://purl.obolibrary.org/obo/GO_0030162)
-- [regulation of peptidase activity](http://purl.obolibrary.org/obo/GO_0052547) SubClassOf [regulation of hydrolase activity](http://purl.obolibrary.org/obo/GO_0051336)
+### spinal cord motor neuron `http://purl.obolibrary.org/obo/CL_0011001`
+#### Removed
+- [spinal cord motor neuron](http://purl.obolibrary.org/obo/CL_0011001) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-### regulation of postsynaptic neurotransmitter receptor activity `http://purl.obolibrary.org/obo/GO_0098962`
+### spiral ganglion neuron `http://purl.obolibrary.org/obo/CL_0011113`
#### Removed
-- [regulation of postsynaptic neurotransmitter receptor activity](http://purl.obolibrary.org/obo/GO_0098962) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [term_scheduled_for_obsoletion](http://purl.obolibrary.org/obo/go#term_scheduled_for_obsoletion)
+- [spiral ganglion neuron](http://purl.obolibrary.org/obo/CL_0011113) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-#### Added
-- [regulation of postsynaptic neurotransmitter receptor activity](http://purl.obolibrary.org/obo/GO_0098962) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate)
-### regulation of protein binding `http://purl.obolibrary.org/obo/GO_0043393`
+### splanchnic nerve `http://purl.obolibrary.org/obo/UBERON_0003715`
#### Removed
-- [regulation of protein binding](http://purl.obolibrary.org/obo/GO_0043393) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [term_scheduled_for_obsoletion](http://purl.obolibrary.org/obo/go#term_scheduled_for_obsoletion)
+- [splanchnic nerve](http://purl.obolibrary.org/obo/UBERON_0003715) SubClassOf [neuron projection bundle](http://purl.obolibrary.org/obo/CARO_0001001)
-#### Added
-- [regulation of protein binding](http://purl.obolibrary.org/obo/GO_0043393) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate)
-### regulation of protein kinase activity `http://purl.obolibrary.org/obo/GO_0045859`
+### splanchnocranium `http://purl.obolibrary.org/obo/UBERON_0008895`
#### Removed
-- [regulation of protein kinase activity](http://purl.obolibrary.org/obo/GO_0045859) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [term_scheduled_for_obsoletion](http://purl.obolibrary.org/obo/go#term_scheduled_for_obsoletion)
+- [splanchnocranium](http://purl.obolibrary.org/obo/UBERON_0008895) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-#### Added
-- [regulation of protein kinase activity](http://purl.obolibrary.org/obo/GO_0045859) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate)
-### regulation of protein serine/threonine kinase activity `http://purl.obolibrary.org/obo/GO_0071900`
+### spleen primordium `http://purl.obolibrary.org/obo/UBERON_0006293`
#### Removed
-- [regulation of protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0071900) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [term_scheduled_for_obsoletion](http://purl.obolibrary.org/obo/go#term_scheduled_for_obsoletion)
+- [spleen primordium](http://purl.obolibrary.org/obo/UBERON_0006293) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-#### Added
-- [regulation of protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0071900) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate)
-### regulation of protein tyrosine kinase activity `http://purl.obolibrary.org/obo/GO_0061097`
+### splenic marginal zone macrophage `http://purl.obolibrary.org/obo/CL_0000872`
#### Removed
-- [regulation of protein tyrosine kinase activity](http://purl.obolibrary.org/obo/GO_0061097) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [term_scheduled_for_obsoletion](http://purl.obolibrary.org/obo/go#term_scheduled_for_obsoletion)
+- [splenic marginal zone macrophage](http://purl.obolibrary.org/obo/CL_0000872) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-#### Added
-- [regulation of protein tyrosine kinase activity](http://purl.obolibrary.org/obo/GO_0061097) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate)
-### regulation of receptor binding `http://purl.obolibrary.org/obo/GO_1900120`
+### splenic metallophillic macrophage `http://purl.obolibrary.org/obo/CL_0000873`
#### Removed
-- [regulation of receptor binding](http://purl.obolibrary.org/obo/GO_1900120) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [term_scheduled_for_obsoletion](http://purl.obolibrary.org/obo/go#term_scheduled_for_obsoletion)
+- [splenic metallophillic macrophage](http://purl.obolibrary.org/obo/CL_0000873) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-#### Added
-- [regulation of receptor binding](http://purl.obolibrary.org/obo/GO_1900120) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate)
-### regulation of signaling receptor activity `http://purl.obolibrary.org/obo/GO_0010469`
+### splenic red pulp macrophage `http://purl.obolibrary.org/obo/CL_0000874`
#### Removed
-- [regulation of signaling receptor activity](http://purl.obolibrary.org/obo/GO_0010469) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [term_scheduled_for_obsoletion](http://purl.obolibrary.org/obo/go#term_scheduled_for_obsoletion)
+- [splenic red pulp macrophage](http://purl.obolibrary.org/obo/CL_0000874) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-#### Added
-- [regulation of signaling receptor activity](http://purl.obolibrary.org/obo/GO_0010469) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate)
-### regulation of transferase activity `http://purl.obolibrary.org/obo/GO_0051338`
+### splenic white pulp macrophage `http://purl.obolibrary.org/obo/CL_0000876`
#### Removed
-- [regulation of transferase activity](http://purl.obolibrary.org/obo/GO_0051338) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [term_scheduled_for_obsoletion](http://purl.obolibrary.org/obo/go#term_scheduled_for_obsoletion)
+- [splenic white pulp macrophage](http://purl.obolibrary.org/obo/CL_0000876) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-#### Added
-- [regulation of transferase activity](http://purl.obolibrary.org/obo/GO_0051338) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate)
-### regulation of transmembrane transporter activity `http://purl.obolibrary.org/obo/GO_0022898`
+### spongiotrophoblast layer `http://purl.obolibrary.org/obo/UBERON_0004021`
#### Removed
-- [regulation of transmembrane transporter activity](http://purl.obolibrary.org/obo/GO_0022898) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [term_scheduled_for_obsoletion](http://purl.obolibrary.org/obo/go#term_scheduled_for_obsoletion)
+- [spongiotrophoblast layer](http://purl.obolibrary.org/obo/UBERON_0004021) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-#### Added
-- [regulation of transmembrane transporter activity](http://purl.obolibrary.org/obo/GO_0022898) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate)
-### regulation of transporter activity `http://purl.obolibrary.org/obo/GO_0032409`
-#### Removed
-- [regulation of transporter activity](http://purl.obolibrary.org/obo/GO_0032409) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [term_scheduled_for_obsoletion](http://purl.obolibrary.org/obo/go#term_scheduled_for_obsoletion)
+### sst GABAergic cortical interneuron `http://purl.obolibrary.org/obo/CL_4023017`
#### Added
-- [regulation of transporter activity](http://purl.obolibrary.org/obo/GO_0032409) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate)
+- [sst GABAergic cortical interneuron](http://purl.obolibrary.org/obo/CL_4023017) [symbol](http://purl.obolibrary.org/obo/IAO_0000028) "sst cortical interneuron"
-### regulation of water channel activity `http://purl.obolibrary.org/obo/GO_1902427`
-#### Removed
-- [regulation of water channel activity](http://purl.obolibrary.org/obo/GO_1902427) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [term_scheduled_for_obsoletion](http://purl.obolibrary.org/obo/go#term_scheduled_for_obsoletion)
+### sst chodl GABAergic cortical interneuron `http://purl.obolibrary.org/obo/CL_4023121`
#### Added
-- [regulation of water channel activity](http://purl.obolibrary.org/obo/GO_1902427) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate)
+- [sst chodl GABAergic cortical interneuron](http://purl.obolibrary.org/obo/CL_4023121) [symbol](http://purl.obolibrary.org/obo/IAO_0000028) "sst chodl cortical interneuron"
-### relaxin family peptide receptor protein `http://purl.obolibrary.org/obo/PR_000001551`
+### stellate L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (Mmus) `http://purl.obolibrary.org/obo/CL_4023080`
#### Added
-- [relaxin family peptide receptor protein](http://purl.obolibrary.org/obo/PR_000001551) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "Category=family."
-
-- [relaxin family peptide receptor protein](http://purl.obolibrary.org/obo/PR_000001551) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "IUPHARfam:60"
+- [stellate L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (Mmus)](http://purl.obolibrary.org/obo/CL_4023080) [symbol](http://purl.obolibrary.org/obo/IAO_0000028) "stellate L6 IT glut MOp"
-- [relaxin family peptide receptor protein](http://purl.obolibrary.org/obo/PR_000001551) [label](http://www.w3.org/2000/01/rdf-schema#label) "relaxin family peptide receptor protein"
-- [relaxin family peptide receptor protein](http://purl.obolibrary.org/obo/PR_000001551) [id](http://www.geneontology.org/formats/oboInOwl#id) "PR:000001551"
-
-- [relaxin family peptide receptor protein](http://purl.obolibrary.org/obo/PR_000001551) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A rhodopsin-like G-protein coupled receptor that is a translation product of the human RXFP1 to RXFP4 genes, 1:1 orthologs thereof, or a semi-ortholog thereof. The active form binds relaxins."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PRO:XQ"
+### stomach primordium `http://purl.obolibrary.org/obo/UBERON_0012172`
+#### Removed
+- [stomach primordium](http://purl.obolibrary.org/obo/UBERON_0012172) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PRO:WCB"
-- [relaxin family peptide receptor protein](http://purl.obolibrary.org/obo/PR_000001551) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "fam:RXFP"
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [PRO-short-label](http://purl.obolibrary.org/obo/pr#PRO-short-label)
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PRO:DNx"
+### stratified epithelial cell `http://purl.obolibrary.org/obo/CL_0000079`
+#### Removed
+- [stratified epithelial cell](http://purl.obolibrary.org/obo/CL_0000079) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [relaxin family peptide receptor protein](http://purl.obolibrary.org/obo/PR_000001551) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "relaxin receptor"
-- [relaxin family peptide receptor protein](http://purl.obolibrary.org/obo/PR_000001551) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PIRSF:PIRSF038662"
-- [relaxin family peptide receptor protein](http://purl.obolibrary.org/obo/PR_000001551) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "protein"
+### stratum basale of epidermis `http://purl.obolibrary.org/obo/UBERON_0002025`
+#### Removed
+- [stratum basale of epidermis](http://purl.obolibrary.org/obo/UBERON_0002025) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- Class: [relaxin family peptide receptor protein](http://purl.obolibrary.org/obo/PR_000001551)
-- [relaxin family peptide receptor protein](http://purl.obolibrary.org/obo/PR_000001551) SubClassOf [rhodopsin-like G-protein coupled receptor](http://purl.obolibrary.org/obo/PR_000001094)
+### stratum granulosum of epidermis `http://purl.obolibrary.org/obo/UBERON_0002069`
+#### Removed
+- [stratum granulosum of epidermis](http://purl.obolibrary.org/obo/UBERON_0002069) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-### relaxin receptor 1 `http://purl.obolibrary.org/obo/PR_000001666`
-#### Added
-- [relaxin receptor 1](http://purl.obolibrary.org/obo/PR_000001666) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "RXFP1"
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [PRO-short-label](http://purl.obolibrary.org/obo/pr#PRO-short-label)
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PRO:DNx"
+### stratum spinosum of epidermis `http://purl.obolibrary.org/obo/UBERON_0002026`
+#### Removed
+- [stratum spinosum of epidermis](http://purl.obolibrary.org/obo/UBERON_0002026) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-- [relaxin receptor 1](http://purl.obolibrary.org/obo/PR_000001666) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "relaxin family peptide receptor 1"
-- [relaxin receptor 1](http://purl.obolibrary.org/obo/PR_000001666) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "Category=gene."
-- [relaxin receptor 1](http://purl.obolibrary.org/obo/PR_000001666) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "protein"
+### stroma of bone marrow `http://purl.obolibrary.org/obo/UBERON_0007195`
+#### Removed
+- [stroma of bone marrow](http://purl.obolibrary.org/obo/UBERON_0007195) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [relaxin receptor 1](http://purl.obolibrary.org/obo/PR_000001666) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "leucine-rich repeat-containing G-protein coupled receptor 7"
-- [relaxin receptor 1](http://purl.obolibrary.org/obo/PR_000001666) [id](http://www.geneontology.org/formats/oboInOwl#id) "PR:000001666"
-- [relaxin receptor 1](http://purl.obolibrary.org/obo/PR_000001666) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A relaxin family peptide receptor protein that is a translation product of the human RXFP1 gene or a 1:1 ortholog thereof. This receptor is expressed in the brain, kidney, testis, placenta, uterus, ovary, adrenal, prostate, skin and heart."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PRO:WCB"
+### stromal cell `http://purl.obolibrary.org/obo/CL_0000499`
+#### Removed
+- [stromal cell](http://purl.obolibrary.org/obo/CL_0000499) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "UniProtKB:Q9HBX9"
-- [relaxin receptor 1](http://purl.obolibrary.org/obo/PR_000001666) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "LGR7"
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [Gene-based](http://purl.obolibrary.org/obo/pr#Gene-based)
-- [relaxin receptor 1](http://purl.obolibrary.org/obo/PR_000001666) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "IUPHARobj:351"
+### structure with developmental contribution from neural crest `http://purl.obolibrary.org/obo/UBERON_0010314`
+#### Removed
+- [structure with developmental contribution from neural crest](http://purl.obolibrary.org/obo/UBERON_0010314) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [relaxin receptor 1](http://purl.obolibrary.org/obo/PR_000001666) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "Gm1018"
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [Gene-based](http://purl.obolibrary.org/obo/pr#Gene-based)
-- [relaxin receptor 1](http://purl.obolibrary.org/obo/PR_000001666) [label](http://www.w3.org/2000/01/rdf-schema#label) "relaxin receptor 1"
-- Class: [relaxin receptor 1](http://purl.obolibrary.org/obo/PR_000001666)
+### stylopod `http://purl.obolibrary.org/obo/UBERON_0002472`
+#### Removed
+- [stylopod](http://purl.obolibrary.org/obo/UBERON_0002472) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000)
-- [relaxin receptor 1](http://purl.obolibrary.org/obo/PR_000001666) SubClassOf [relaxin family peptide receptor protein](http://purl.obolibrary.org/obo/PR_000001551)
-### relaxin receptor 1 (human) `http://purl.obolibrary.org/obo/PR_Q9HBX9`
+### stylopodial skeleton `http://purl.obolibrary.org/obo/UBERON_0011583`
+#### Removed
+- [stylopodial skeleton](http://purl.obolibrary.org/obo/UBERON_0011583) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000)
-#### Added
-- [relaxin receptor 1 (human)](http://purl.obolibrary.org/obo/PR_Q9HBX9) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "protein"
-- [relaxin receptor 1 (human)](http://purl.obolibrary.org/obo/PR_Q9HBX9) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "leucine-rich repeat-containing G-protein coupled receptor 7 (human)"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "UniProtKB:Q9HBX9"
-- [relaxin receptor 1 (human)](http://purl.obolibrary.org/obo/PR_Q9HBX9) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A relaxin receptor 1 that is encoded in the genome of human."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PRO:WCB"
+### subserosa `http://purl.obolibrary.org/obo/UBERON_0012375`
+#### Removed
+- [subserosa](http://purl.obolibrary.org/obo/UBERON_0012375) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "UniProtKB:Q9HBX9"
-- [relaxin receptor 1 (human)](http://purl.obolibrary.org/obo/PR_Q9HBX9) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "LGR7"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "UniProtKB:Q9HBX9"
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [Gene-based](http://purl.obolibrary.org/obo/pr#Gene-based)
+### substantia propria of cornea `http://purl.obolibrary.org/obo/UBERON_0001777`
+#### Removed
+- [substantia propria of cornea](http://purl.obolibrary.org/obo/UBERON_0001777) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [relaxin receptor 1 (human)](http://purl.obolibrary.org/obo/PR_Q9HBX9) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-444834"
- - [label](http://www.w3.org/2000/01/rdf-schema#label) "PR:Q9HBX9 located_in GO:0005886"
-- [relaxin receptor 1 (human)](http://purl.obolibrary.org/obo/PR_Q9HBX9) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "RXFP1"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "UniProtKB:Q9HBX9"
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [Gene-based](http://purl.obolibrary.org/obo/pr#Gene-based)
+### symbol `http://purl.obolibrary.org/obo/IAO_0000028`
-- [relaxin receptor 1 (human)](http://purl.obolibrary.org/obo/PR_Q9HBX9) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "Category=organism-gene."
+#### Added
+- [symbol](http://purl.obolibrary.org/obo/IAO_0000028) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "symbol"@en
-- [relaxin receptor 1 (human)](http://purl.obolibrary.org/obo/PR_Q9HBX9) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "UniProtKB:Q9HBX9"
+- [symbol](http://purl.obolibrary.org/obo/IAO_0000028) [label](http://www.w3.org/2000/01/rdf-schema#label) "symbol"@en
-- [relaxin receptor 1 (human)](http://purl.obolibrary.org/obo/PR_Q9HBX9) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "relaxin family peptide receptor 1 (human)"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "UniProtKB:Q9HBX9"
+- [symbol](http://purl.obolibrary.org/obo/IAO_0000028) [IAO_0000114](http://purl.obolibrary.org/obo/IAO_0000114) [pending final vetting](http://purl.obolibrary.org/obo/IAO_0000125)
-- [relaxin receptor 1 (human)](http://purl.obolibrary.org/obo/PR_Q9HBX9) [id](http://www.geneontology.org/formats/oboInOwl#id) "PR:Q9HBX9"
+- [symbol](http://purl.obolibrary.org/obo/IAO_0000028) [editor note](http://purl.obolibrary.org/obo/IAO_0000116) "20091104, MC: this needs work and will most probably change"@en
-- [relaxin receptor 1 (human)](http://purl.obolibrary.org/obo/PR_Q9HBX9) [label](http://www.w3.org/2000/01/rdf-schema#label) "relaxin receptor 1 (human)"
+- [symbol](http://purl.obolibrary.org/obo/IAO_0000028) [IAO_0000112](http://purl.obolibrary.org/obo/IAO_0000112) "a written proper name such as "OBI""@en
-- [relaxin receptor 1 (human)](http://purl.obolibrary.org/obo/PR_Q9HBX9) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "hRXFP1"
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [PRO-short-label](http://purl.obolibrary.org/obo/pr#PRO-short-label)
+- [symbol](http://purl.obolibrary.org/obo/IAO_0000028) [IAO_0000119](http://purl.obolibrary.org/obo/IAO_0000119) "based on Oxford English Dictionary"@en
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PRO:DNx"
+- [symbol](http://purl.obolibrary.org/obo/IAO_0000028) [IAO_0000117](http://purl.obolibrary.org/obo/IAO_0000117) "PERSON: James A. Overton"@en
-- [relaxin receptor 1 (human)](http://purl.obolibrary.org/obo/PR_Q9HBX9) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "DTO:02100761"
+- [symbol](http://purl.obolibrary.org/obo/IAO_0000028) [editor note](http://purl.obolibrary.org/obo/IAO_0000116) "2014-03-31: We would like to have a deeper analysis of 'mark' and 'sign' in the future (see https://github.com/information-artifact-ontology/IAO/issues/154)."@en
-- Class: [relaxin receptor 1 (human)](http://purl.obolibrary.org/obo/PR_Q9HBX9)
+- [symbol](http://purl.obolibrary.org/obo/IAO_0000028) [IAO_0000112](http://purl.obolibrary.org/obo/IAO_0000112) "a serial number such as "12324X""@en
-- [relaxin receptor 1 (human)](http://purl.obolibrary.org/obo/PR_Q9HBX9) EquivalentTo [relaxin receptor 1](http://purl.obolibrary.org/obo/PR_000001666) and ([only in taxon](http://purl.obolibrary.org/obo/RO_0002160) some [Homo sapiens](http://purl.obolibrary.org/obo/NCBITaxon_9606))
+- [symbol](http://purl.obolibrary.org/obo/IAO_0000028) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "An information content entity that is a mark(s) or character(s) used as a conventional representation of another entity."@en
-- [relaxin receptor 1 (human)](http://purl.obolibrary.org/obo/PR_Q9HBX9) SubClassOf [relaxin receptor 1](http://purl.obolibrary.org/obo/PR_000001666)
+- [symbol](http://purl.obolibrary.org/obo/IAO_0000028) [IAO_0000117](http://purl.obolibrary.org/obo/IAO_0000117) "PERSON: Jonathan Rees"@en
-- [relaxin receptor 1 (human)](http://purl.obolibrary.org/obo/PR_Q9HBX9) SubClassOf [Homo sapiens protein](http://purl.obolibrary.org/obo/PR_000029067)
+- [symbol](http://purl.obolibrary.org/obo/IAO_0000028) [IAO_0000112](http://purl.obolibrary.org/obo/IAO_0000112) "a stop sign"@en
+- Class: [symbol](http://purl.obolibrary.org/obo/IAO_0000028)
-### relaxin receptor 1 (mouse) `http://purl.obolibrary.org/obo/PR_Q6R6I7`
+- AnnotationProperty: [symbol](http://purl.obolibrary.org/obo/IAO_0000028)
-#### Added
-- [relaxin receptor 1 (mouse)](http://purl.obolibrary.org/obo/PR_Q6R6I7) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "relaxin family peptide receptor 1 (mouse)"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "UniProtKB:Q6R6I7"
+- [symbol](http://purl.obolibrary.org/obo/IAO_0000028) SubClassOf [information content entity](http://purl.obolibrary.org/obo/IAO_0000030)
-- [relaxin receptor 1 (mouse)](http://purl.obolibrary.org/obo/PR_Q6R6I7) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "protein"
-- [relaxin receptor 1 (mouse)](http://purl.obolibrary.org/obo/PR_Q6R6I7) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "Gm1018"
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [Gene-based](http://purl.obolibrary.org/obo/pr#Gene-based)
+### synapsed_by `http://purl.obolibrary.org/obo/uberon/core#synapsed_by`
+#### Removed
+- ObjectProperty: [synapsed_by](http://purl.obolibrary.org/obo/uberon/core#synapsed_by)
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "UniProtKB:Q6R6I7"
-- [relaxin receptor 1 (mouse)](http://purl.obolibrary.org/obo/PR_Q6R6I7) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "Lgr7"
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [Gene-based](http://purl.obolibrary.org/obo/pr#Gene-based)
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "UniProtKB:Q6R6I7"
+### synchronous hermaphroditic organism `http://purl.obolibrary.org/obo/UBERON_0010899`
+#### Removed
+- [synchronous hermaphroditic organism](http://purl.obolibrary.org/obo/UBERON_0010899) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-- [relaxin receptor 1 (mouse)](http://purl.obolibrary.org/obo/PR_Q6R6I7) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "Rxfp1"
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [Gene-based](http://purl.obolibrary.org/obo/pr#Gene-based)
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "UniProtKB:Q6R6I7"
-- [relaxin receptor 1 (mouse)](http://purl.obolibrary.org/obo/PR_Q6R6I7) [id](http://www.geneontology.org/formats/oboInOwl#id) "PR:Q6R6I7"
+### syndecan-1 `http://purl.obolibrary.org/obo/PR_000001935`
-- [relaxin receptor 1 (mouse)](http://purl.obolibrary.org/obo/PR_Q6R6I7) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "mRXFP1"
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [PRO-short-label](http://purl.obolibrary.org/obo/pr#PRO-short-label)
+#### Added
+- [syndecan-1](http://purl.obolibrary.org/obo/PR_000001935) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [syndecan-1 (human)](http://purl.obolibrary.org/obo/PR_P18827)
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PRO:DNx"
-- [relaxin receptor 1 (mouse)](http://purl.obolibrary.org/obo/PR_Q6R6I7) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "leucine-rich repeat-containing G-protein coupled receptor 7 (mouse)"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "UniProtKB:Q6R6I7"
+### synovial membrane of synovial joint `http://purl.obolibrary.org/obo/UBERON_0002018`
+#### Removed
+- [synovial membrane of synovial joint](http://purl.obolibrary.org/obo/UBERON_0002018) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000)
-- [relaxin receptor 1 (mouse)](http://purl.obolibrary.org/obo/PR_Q6R6I7) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "UniProtKB:Q6R6I7"
-- [relaxin receptor 1 (mouse)](http://purl.obolibrary.org/obo/PR_Q6R6I7) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "Category=organism-gene."
-- [relaxin receptor 1 (mouse)](http://purl.obolibrary.org/obo/PR_Q6R6I7) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A relaxin receptor 1 that is encoded in the genome of mouse."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PRO:DNx"
+### tachykinin-3 `http://purl.obolibrary.org/obo/PR_000016004`
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "OMA:Q6R6I7"
+#### Added
+- [tachykinin-3](http://purl.obolibrary.org/obo/PR_000016004) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [tachykinin-3 (human)](http://purl.obolibrary.org/obo/PR_Q9UHF0)
-- [relaxin receptor 1 (mouse)](http://purl.obolibrary.org/obo/PR_Q6R6I7) [label](http://www.w3.org/2000/01/rdf-schema#label) "relaxin receptor 1 (mouse)"
-- Class: [relaxin receptor 1 (mouse)](http://purl.obolibrary.org/obo/PR_Q6R6I7)
+### tartrate-resistant acid phosphatase type 5 `http://purl.obolibrary.org/obo/PR_000001937`
-- [relaxin receptor 1 (mouse)](http://purl.obolibrary.org/obo/PR_Q6R6I7) EquivalentTo [relaxin receptor 1](http://purl.obolibrary.org/obo/PR_000001666) and ([only in taxon](http://purl.obolibrary.org/obo/RO_0002160) some [Mus musculus](http://purl.obolibrary.org/obo/NCBITaxon_10090))
+#### Added
+- [tartrate-resistant acid phosphatase type 5](http://purl.obolibrary.org/obo/PR_000001937) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [tartrate-resistant acid phosphatase type 5 (human)](http://purl.obolibrary.org/obo/PR_P13686)
-- [relaxin receptor 1 (mouse)](http://purl.obolibrary.org/obo/PR_Q6R6I7) SubClassOf [Mus musculus protein](http://purl.obolibrary.org/obo/PR_000029032)
-- [relaxin receptor 1 (mouse)](http://purl.obolibrary.org/obo/PR_Q6R6I7) SubClassOf [relaxin receptor 1](http://purl.obolibrary.org/obo/PR_000001666)
+### telencephalic ventricle `http://purl.obolibrary.org/obo/UBERON_0002285`
+#### Removed
+- [telencephalic ventricle](http://purl.obolibrary.org/obo/UBERON_0002285) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-### renal glomerulus `http://purl.obolibrary.org/obo/UBERON_0000074`
-#### Added
-- [renal glomerulus](http://purl.obolibrary.org/obo/UBERON_0000074) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [human_reference_atlas](http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas)
+### tendon sheath `http://purl.obolibrary.org/obo/UBERON_0000304`
+#### Removed
+- [tendon sheath](http://purl.obolibrary.org/obo/UBERON_0000304) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [renal glomerulus](http://purl.obolibrary.org/obo/UBERON_0000074) [present_in_taxon](http://purl.obolibrary.org/obo/RO_0002175) [Homo sapiens](http://purl.obolibrary.org/obo/NCBITaxon_9606)
-### respiratory suprabasal cell `http://purl.obolibrary.org/obo/CL_4033048`
+### term imported `http://purl.obolibrary.org/obo/IAO_0000228`
#### Added
-- [respiratory suprabasal cell](http://purl.obolibrary.org/obo/CL_4033048) [date](http://purl.org/dc/terms/date) "2023-06-20T10:44:30Z"^^[dateTime](http://www.w3.org/2001/XMLSchema#dateTime)
+- [term imported](http://purl.obolibrary.org/obo/IAO_0000228) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "term imported"@en
-- [respiratory suprabasal cell](http://purl.obolibrary.org/obo/CL_4033048) [label](http://www.w3.org/2000/01/rdf-schema#label) "respiratory suprabasal cell"
+- [term imported](http://purl.obolibrary.org/obo/IAO_0000228) [editor note](http://purl.obolibrary.org/obo/IAO_0000116) "This is to be used when the original term has been replaced by a term imported from an other ontology. An editor note should indicate what is the URI of the new term to use."@en
-- [respiratory suprabasal cell](http://purl.obolibrary.org/obo/CL_4033048) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A respiratory epithelial cell with topographic nuclear position in between the basal and luminal cell of the airway epithelium. This non-basal, intermediate cell has limited proliferative capacity, ultrastructural features of basal cells and no defined features of the typically differentiated cellular phenotypes."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:25564622"
+- [term imported](http://purl.obolibrary.org/obo/IAO_0000228) [label](http://www.w3.org/2000/01/rdf-schema#label) "term imported"@en
-- [respiratory suprabasal cell](http://purl.obolibrary.org/obo/CL_4033048) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "respiratory parabasal cell"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:25564622"
+- Individual: [term imported](http://purl.obolibrary.org/obo/IAO_0000228)
-- [respiratory suprabasal cell](http://purl.obolibrary.org/obo/CL_4033048) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "respiratory suprabasal progenitor cell"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:25658372"
-- [respiratory suprabasal cell](http://purl.obolibrary.org/obo/CL_4033048) [contributor](http://purl.org/dc/terms/contributor) [0000-0002-9185-3994](https://orcid.org/0000-0002-9185-3994)
+### term replaced by `http://purl.obolibrary.org/obo/IAO_0100001`
-- [respiratory suprabasal cell](http://purl.obolibrary.org/obo/CL_4033048) [contributor](http://purl.org/dc/terms/contributor) [0000-0001-6677-8489](https://orcid.org/0000-0001-6677-8489)
-
-- [respiratory suprabasal cell](http://purl.obolibrary.org/obo/CL_4033048) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "In humans, respiratory suprabasal cells have been noted to have enriched expression of the following: CK8, KRT13, IVL, and SERPINB3."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1101/2023.04.20.537495"
+#### Added
+- [term replaced by](http://purl.obolibrary.org/obo/IAO_0100001) [IAO_0000114](http://purl.obolibrary.org/obo/IAO_0000114) [pending final vetting](http://purl.obolibrary.org/obo/IAO_0000125)
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:25658372"
+- [term replaced by](http://purl.obolibrary.org/obo/IAO_0100001) [IAO_0000119](http://purl.obolibrary.org/obo/IAO_0000119) "Person:Alan Ruttenberg"@en
-- Class: [respiratory suprabasal cell](http://purl.obolibrary.org/obo/CL_4033048)
+- [term replaced by](http://purl.obolibrary.org/obo/IAO_0100001) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "term replaced by"@en
-- [respiratory suprabasal cell](http://purl.obolibrary.org/obo/CL_4033048) SubClassOf [respiratory epithelial cell](http://purl.obolibrary.org/obo/CL_0002368)
+- [term replaced by](http://purl.obolibrary.org/obo/IAO_0100001) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "Add as annotation triples in the granting ontology"@en
-- [respiratory suprabasal cell](http://purl.obolibrary.org/obo/CL_4033048) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [respiratory tract epithelium](http://purl.obolibrary.org/obo/UBERON_0004802)
+- [term replaced by](http://purl.obolibrary.org/obo/IAO_0100001) [IAO_0000117](http://purl.obolibrary.org/obo/IAO_0000117) "Person:Alan Ruttenberg"@en
-- [respiratory suprabasal cell](http://purl.obolibrary.org/obo/CL_4033048) SubClassOf [progenitor cell](http://purl.obolibrary.org/obo/CL_0011026)
+- [term replaced by](http://purl.obolibrary.org/obo/IAO_0100001) [label](http://www.w3.org/2000/01/rdf-schema#label) "term replaced by"@en
-- [respiratory suprabasal cell](http://purl.obolibrary.org/obo/CL_4033048) SubClassOf [develops from](http://purl.obolibrary.org/obo/RO_0002202) some [respiratory basal cell](http://purl.obolibrary.org/obo/CL_0002633)
+- [term replaced by](http://purl.obolibrary.org/obo/IAO_0100001) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Use on obsolete terms, relating the term to another term that can be used as a substitute"@en
-### response to ATP `http://purl.obolibrary.org/obo/GO_0033198`
+### term split `http://purl.obolibrary.org/obo/IAO_0000229`
#### Added
-- [response to ATP](http://purl.obolibrary.org/obo/GO_0033198) [label](http://www.w3.org/2000/01/rdf-schema#label) "response to ATP"
+- [term split](http://purl.obolibrary.org/obo/IAO_0000229) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "term split"@en
-- [response to ATP](http://purl.obolibrary.org/obo/GO_0033198) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "response to adenosine triphosphate"
+- [term split](http://purl.obolibrary.org/obo/IAO_0000229) [label](http://www.w3.org/2000/01/rdf-schema#label) "term split"@en
-- [response to ATP](http://purl.obolibrary.org/obo/GO_0033198) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ATP (adenosine 5'-triphosphate) stimulus."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:sl"
+- [term split](http://purl.obolibrary.org/obo/IAO_0000229) [editor note](http://purl.obolibrary.org/obo/IAO_0000116) "This is to be used when a term has been split in two or more new terms. An editor note should indicate the reason for the split and indicate the URIs of the new terms created."@en
-- [response to ATP](http://purl.obolibrary.org/obo/GO_0033198) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "response to adenosine 5'-triphosphate"
+- Individual: [term split](http://purl.obolibrary.org/obo/IAO_0000229)
-- [response to ATP](http://purl.obolibrary.org/obo/GO_0033198) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0033198"
-- [response to ATP](http://purl.obolibrary.org/obo/GO_0033198) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process"
+### term tracker item `http://purl.obolibrary.org/obo/IAO_0000233`
-- Class: [response to ATP](http://purl.obolibrary.org/obo/GO_0033198)
+#### Added
+- [term tracker item](http://purl.obolibrary.org/obo/IAO_0000233) [label](http://www.w3.org/2000/01/rdf-schema#label) "term tracker item"@en
-- [response to ATP](http://purl.obolibrary.org/obo/GO_0033198) EquivalentTo [response to stimulus](http://purl.obolibrary.org/obo/GO_0050896) and ([has input](http://purl.obolibrary.org/obo/RO_0002233) some [CHEBI_30616](http://purl.obolibrary.org/obo/CHEBI_30616))
+- [term tracker item](http://purl.obolibrary.org/obo/IAO_0000233) [IAO_0000119](http://purl.obolibrary.org/obo/IAO_0000119) "Person: Jie Zheng, Chris Stoeckert, Alan Ruttenberg"@en
-- [response to ATP](http://purl.obolibrary.org/obo/GO_0033198) SubClassOf [has input](http://purl.obolibrary.org/obo/RO_0002233) some [CHEBI_30616](http://purl.obolibrary.org/obo/CHEBI_30616)
+- [term tracker item](http://purl.obolibrary.org/obo/IAO_0000233) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "The 'tracker item' can associate a tracker with a specific ontology term."@en
-- [response to ATP](http://purl.obolibrary.org/obo/GO_0033198) SubClassOf [response to stimulus](http://purl.obolibrary.org/obo/GO_0050896)
+- [term tracker item](http://purl.obolibrary.org/obo/IAO_0000233) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "An IRI or similar locator for a request or discussion of an ontology term."@en
+- [term tracker item](http://purl.obolibrary.org/obo/IAO_0000233) [IAO_0000114](http://purl.obolibrary.org/obo/IAO_0000114) [pending final vetting](http://purl.obolibrary.org/obo/IAO_0000125)
-### retinal cell `http://purl.obolibrary.org/obo/CL_0009004`
+- [term tracker item](http://purl.obolibrary.org/obo/IAO_0000233) [IAO_0000117](http://purl.obolibrary.org/obo/IAO_0000117) "Person: Jie Zheng, Chris Stoeckert, Alan Ruttenberg"@en
-#### Added
-- [retinal cell](http://purl.obolibrary.org/obo/CL_0009004) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [general_cell_types_upper_slim](http://purl.obolibrary.org/obo/cl#general_cell_types_upper_slim)
+- [term tracker item](http://purl.obolibrary.org/obo/IAO_0000233) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "term tracker item"@en
+- [term tracker item](http://purl.obolibrary.org/obo/IAO_0000233) [IAO_0000112](http://purl.obolibrary.org/obo/IAO_0000112) "the URI for an OBI Terms ticket at sourceforge, such as https://sourceforge.net/p/obi/obi-terms/772/"@en
-### ribonucleoside triphosphate phosphatase activity `http://purl.obolibrary.org/obo/GO_0017111`
-#### Added
-- [ribonucleoside triphosphate phosphatase activity](http://purl.obolibrary.org/obo/GO_0017111) SubClassOf [has participant](http://purl.obolibrary.org/obo/RO_0000057) some [CHEBI_57930](http://purl.obolibrary.org/obo/CHEBI_57930)
+### terminal bronchiole epithelium `http://purl.obolibrary.org/obo/UBERON_0001958`
+#### Removed
+- [terminal bronchiole epithelium](http://purl.obolibrary.org/obo/UBERON_0001958) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-- [ribonucleoside triphosphate phosphatase activity](http://purl.obolibrary.org/obo/GO_0017111) SubClassOf [has participant](http://purl.obolibrary.org/obo/RO_0000057) some [CHEBI_15378](http://purl.obolibrary.org/obo/CHEBI_15378)
-- [ribonucleoside triphosphate phosphatase activity](http://purl.obolibrary.org/obo/GO_0017111) SubClassOf [has participant](http://purl.obolibrary.org/obo/RO_0000057) some [CHEBI_43474](http://purl.obolibrary.org/obo/CHEBI_43474)
-- [ribonucleoside triphosphate phosphatase activity](http://purl.obolibrary.org/obo/GO_0017111) SubClassOf [has participant](http://purl.obolibrary.org/obo/RO_0000057) some [CHEBI_61557](http://purl.obolibrary.org/obo/CHEBI_61557)
+### terminal part of digestive tract `http://purl.obolibrary.org/obo/UBERON_0006866`
+#### Removed
+- [terminal part of digestive tract](http://purl.obolibrary.org/obo/UBERON_0006866) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [ribonucleoside triphosphate phosphatase activity](http://purl.obolibrary.org/obo/GO_0017111) SubClassOf [has participant](http://purl.obolibrary.org/obo/RO_0000057) some [CHEBI_15377](http://purl.obolibrary.org/obo/CHEBI_15377)
-### right putamen `http://purl.obolibrary.org/obo/UBERON_0008885`
+### terms merged `http://purl.obolibrary.org/obo/IAO_0000227`
#### Added
-- [right putamen](http://purl.obolibrary.org/obo/UBERON_0008885) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "HBA:4289"
+- [terms merged](http://purl.obolibrary.org/obo/IAO_0000227) [label](http://www.w3.org/2000/01/rdf-schema#label) "terms merged"@en
-- [right putamen](http://purl.obolibrary.org/obo/UBERON_0008885) [label](http://www.w3.org/2000/01/rdf-schema#label) "right putamen"
+- [terms merged](http://purl.obolibrary.org/obo/IAO_0000227) [editor note](http://purl.obolibrary.org/obo/IAO_0000116) "An editor note should explain what were the merged terms and the reason for the merge."@en
-- [right putamen](http://purl.obolibrary.org/obo/UBERON_0008885) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "FMA:72828"
+- [terms merged](http://purl.obolibrary.org/obo/IAO_0000227) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "terms merged"@en
-- [right putamen](http://purl.obolibrary.org/obo/UBERON_0008885) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A putamen that is part of a right cerebral hemisphere."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "OBOL:automatic"
+- Individual: [terms merged](http://purl.obolibrary.org/obo/IAO_0000227)
-- [right putamen](http://purl.obolibrary.org/obo/UBERON_0008885) [id](http://www.geneontology.org/formats/oboInOwl#id) "UBERON:0008885"
-- [right putamen](http://purl.obolibrary.org/obo/UBERON_0008885) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "uberon"
+### tetrapod frontal bone primordium `http://purl.obolibrary.org/obo/UBERON_0006236`
+#### Removed
+- [tetrapod frontal bone primordium](http://purl.obolibrary.org/obo/UBERON_0006236) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- Class: [right putamen](http://purl.obolibrary.org/obo/UBERON_0008885)
-- [right putamen](http://purl.obolibrary.org/obo/UBERON_0008885) EquivalentTo [putamen](http://purl.obolibrary.org/obo/UBERON_0001874) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [right cerebral hemisphere](http://purl.obolibrary.org/obo/UBERON_0002813))
-- [right putamen](http://purl.obolibrary.org/obo/UBERON_0008885) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [right cerebral hemisphere](http://purl.obolibrary.org/obo/UBERON_0002813)
+### thalamic excitatory neuron `http://purl.obolibrary.org/obo/CL_4023068`
+#### Removed
+- [thalamic excitatory neuron](http://purl.obolibrary.org/obo/CL_4023068) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [right putamen](http://purl.obolibrary.org/obo/UBERON_0008885) SubClassOf [putamen](http://purl.obolibrary.org/obo/UBERON_0001874)
-### rosehip neuron `http://purl.obolibrary.org/obo/CL_0008032`
+### theca cell layer `http://purl.obolibrary.org/obo/UBERON_0000155`
#### Removed
-- [rosehip neuron](http://purl.obolibrary.org/obo/CL_0008032) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "A rosehip cell has been shown to have an immunohistochemical profile GAD1+CCK+, CNR1–SST–CALB2–PVALB– that matches a single transcriptomically defined cell type whose specific molecular marker signature is not seen in mouse cortex."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "https://www.nature.com/articles/s41593-018-0205-2"
+- [theca cell layer](http://purl.obolibrary.org/obo/UBERON_0000155) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [rosehip neuron](http://purl.obolibrary.org/obo/CL_0008032) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A GABAergic interneuron in human cortical layer 1 that has large rosehip-shaped axonal boutons and compact arborization."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "https://www.nature.com/articles/s41593-018-0205-2"
-#### Added
-- [rosehip neuron](http://purl.obolibrary.org/obo/CL_0008032) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A GABAergic interneuron in human cortical layer 1 that has large rosehip-shaped axonal boutons and compact arborization."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1038/s41593-018-0205-2"
-- [rosehip neuron](http://purl.obolibrary.org/obo/CL_0008032) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "A rosehip cell has been shown to have an immunohistochemical profile GAD1+CCK+, CNR1–SST–CALB2–PVALB– that matches a single transcriptomically defined cell type whose specific molecular marker signature is not seen in mouse cortex."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1038/s41593-018-0205-2"
+### thoracic segment of trunk `http://purl.obolibrary.org/obo/UBERON_0000915`
+#### Removed
+- [thoracic segment of trunk](http://purl.obolibrary.org/obo/UBERON_0000915) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000)
-### scolopale cell `http://purl.obolibrary.org/obo/CL_0000382`
-#### Removed
-- [scolopale cell](http://purl.obolibrary.org/obo/CL_0000382) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A cell that is part of a scolopidium and surrounds the dendrite of a scolopidial neuron."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:https://doi.org/10.1016/B978-012369493-5.50012-2"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1017/CBO9780511818202.024"
+### thrombomodulin `http://purl.obolibrary.org/obo/PR_000002105`
#### Added
-- [scolopale cell](http://purl.obolibrary.org/obo/CL_0000382) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A cell that is part of a scolopidium and surrounds the dendrite of a scolopidial neuron."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/B978-012369493-5.50012-2"
+- [thrombomodulin](http://purl.obolibrary.org/obo/PR_000002105) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [thrombomodulin (human)](http://purl.obolibrary.org/obo/PR_P07204)
+
+
+### thymic plasmacytoid dendritic cell `http://purl.obolibrary.org/obo/CL_0000942`
+#### Removed
+- [thymic plasmacytoid dendritic cell](http://purl.obolibrary.org/obo/CL_0000942) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1017/CBO9780511818202.024"
-### secondary crest myofibroblast `http://purl.obolibrary.org/obo/CL_4033016`
+### thymus corticomedullary boundary `http://purl.obolibrary.org/obo/UBERON_0003988`
#### Removed
-- [secondary crest myofibroblast](http://purl.obolibrary.org/obo/CL_4033016) SubClassOf [connective tissue cell](http://purl.obolibrary.org/obo/CL_0002320)
+- [thymus corticomedullary boundary](http://purl.obolibrary.org/obo/UBERON_0003988) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-### secretory granule maturation `http://purl.obolibrary.org/obo/GO_0061792`
+### thymus epithelium `http://purl.obolibrary.org/obo/UBERON_0003846`
#### Removed
-- [secretory granule maturation](http://purl.obolibrary.org/obo/GO_0061792) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Steps required to transform an immature secretory vesicle into a mature secretory vesicle. Typically proceeds through homotypic membrane fusion and membrane remodelling."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dph"
+- [thymus epithelium](http://purl.obolibrary.org/obo/UBERON_0003846) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:bf"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:PARL"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:16618809"
+### thymus lobule `http://purl.obolibrary.org/obo/UBERON_0002125`
+#### Removed
+- [thymus lobule](http://purl.obolibrary.org/obo/UBERON_0002125) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-#### Added
-- [secretory granule maturation](http://purl.obolibrary.org/obo/GO_0061792) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Steps required to transform an immature secretory vesicle into a mature secretory vesicle. Typically proceeds through homotypic membrane fusion and membrane remodeling."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dph"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:bf"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:PARL"
+### thyroid diverticulum `http://purl.obolibrary.org/obo/UBERON_0007689`
+#### Removed
+- [thyroid diverticulum](http://purl.obolibrary.org/obo/UBERON_0007689) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:16618809"
-### smooth muscle cell `http://purl.obolibrary.org/obo/CL_0000192`
+### to be replaced with external ontology term `http://purl.obolibrary.org/obo/IAO_0000423`
#### Added
-- [smooth muscle cell](http://purl.obolibrary.org/obo/CL_0000192) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [general_cell_types_upper_slim](http://purl.obolibrary.org/obo/cl#general_cell_types_upper_slim)
+- [to be replaced with external ontology term](http://purl.obolibrary.org/obo/IAO_0000423) [IAO_0000117](http://purl.obolibrary.org/obo/IAO_0000117) "Alan Ruttenberg"@en
+- [to be replaced with external ontology term](http://purl.obolibrary.org/obo/IAO_0000423) [IAO_0000119](http://purl.obolibrary.org/obo/IAO_0000119) "group:OBI"@en
-### smooth muscle tissue of bronchiole `http://purl.obolibrary.org/obo/UBERON_0004515`
+- [to be replaced with external ontology term](http://purl.obolibrary.org/obo/IAO_0000423) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Terms with this status should eventually replaced with a term from another ontology."@en
-#### Added
-- [smooth muscle tissue of bronchiole](http://purl.obolibrary.org/obo/UBERON_0004515) [present_in_taxon](http://purl.obolibrary.org/obo/RO_0002175) [Homo sapiens](http://purl.obolibrary.org/obo/NCBITaxon_9606)
+- [to be replaced with external ontology term](http://purl.obolibrary.org/obo/IAO_0000423) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "to be replaced with external ontology term"@en
-- [smooth muscle tissue of bronchiole](http://purl.obolibrary.org/obo/UBERON_0004515) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [human_reference_atlas](http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas)
+- [to be replaced with external ontology term](http://purl.obolibrary.org/obo/IAO_0000423) [label](http://www.w3.org/2000/01/rdf-schema#label) "to be replaced with external ontology term"@en
+- Individual: [to be replaced with external ontology term](http://purl.obolibrary.org/obo/IAO_0000423)
-### stem cell `http://purl.obolibrary.org/obo/CL_0000034`
-#### Added
-- [stem cell](http://purl.obolibrary.org/obo/CL_0000034) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [general_cell_types_upper_slim](http://purl.obolibrary.org/obo/cl#general_cell_types_upper_slim)
+### tooth bud `http://purl.obolibrary.org/obo/UBERON_0008281`
+#### Removed
+- [tooth bud](http://purl.obolibrary.org/obo/UBERON_0008281) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-### stem cell differentiation `http://purl.obolibrary.org/obo/GO_0048863`
-#### Added
-- [stem cell differentiation](http://purl.obolibrary.org/obo/GO_0048863) [never in taxon](http://purl.obolibrary.org/obo/RO_0002161) [Fungi](http://purl.obolibrary.org/obo/NCBITaxon_4751)
+### trabecula carnea `http://purl.obolibrary.org/obo/UBERON_0002511`
+#### Removed
+- [trabecula carnea](http://purl.obolibrary.org/obo/UBERON_0002511) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
-- [stem cell differentiation](http://purl.obolibrary.org/obo/GO_0048863) DisjointWith [in taxon](http://purl.obolibrary.org/obo/RO_0002162) some [Fungi](http://purl.obolibrary.org/obo/NCBITaxon_4751)
-- [stem cell differentiation](http://purl.obolibrary.org/obo/GO_0048863) SubClassOf not ([in taxon](http://purl.obolibrary.org/obo/RO_0002162) some [Fungi](http://purl.obolibrary.org/obo/NCBITaxon_4751))
+### trachea `http://purl.obolibrary.org/obo/UBERON_0003126`
+#### Removed
+- [trachea](http://purl.obolibrary.org/obo/UBERON_0003126) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [stem cell differentiation](http://purl.obolibrary.org/obo/GO_0048863) SubClassOf [in taxon](http://purl.obolibrary.org/obo/RO_0002162) some (not ([Fungi](http://purl.obolibrary.org/obo/NCBITaxon_4751)))
-### striatal medium spiny neuron differentiation `http://purl.obolibrary.org/obo/GO_0021773`
+### trachea connective tissue `http://purl.obolibrary.org/obo/UBERON_0003571`
+#### Removed
+- [trachea connective tissue](http://purl.obolibrary.org/obo/UBERON_0003571) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-#### Added
-- [striatal medium spiny neuron differentiation](http://purl.obolibrary.org/obo/GO_0021773) SubClassOf [GABAergic neuron differentiation](http://purl.obolibrary.org/obo/GO_0097154)
-### striosomal D1 medium spiny neuron `http://purl.obolibrary.org/obo/CL_4030048`
+### trans-acting T-cell-specific transcription factor GATA-3 `http://purl.obolibrary.org/obo/PR_000001941`
#### Added
-- [striosomal D1 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030048) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A DRD1-expressing medium spiny neuron that is part of a striosome of dorsal striatum."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) [j.cub.2021.10.015](DOI:10.1016/j.cub.2021.10.015)
-
-- [striosomal D1 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030048) [date](http://purl.org/dc/terms/date) "2023-06-02T14:50:43Z"^^[dateTime](http://www.w3.org/2001/XMLSchema#dateTime)
+- [trans-acting T-cell-specific transcription factor GATA-3](http://purl.obolibrary.org/obo/PR_000001941) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [trans-acting T-cell-specific transcription factor GATA-3 (human)](http://purl.obolibrary.org/obo/PR_P23771)
-- [striosomal D1 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030048) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "striosome D1 medium spiny neuron"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) [j.cub.2021.10.015](DOI:10.1016/j.cub.2021.10.015)
-- [striosomal D1 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030048) [label](http://www.w3.org/2000/01/rdf-schema#label) "striosomal D1 medium spiny neuron"
+### transcription factor PU.1 `http://purl.obolibrary.org/obo/PR_000001944`
-- [striosomal D1 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030048) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "In Rhesus macaques, both striosomal D1 and D2 medium spiny neuron (MSN) cell types have been noted to have enriched gene expression of the following: KCNT1, KHDRBS3, FAM163A, BACH2, and KCNIP1. Striosomal MSN activations have been noted to influence cognitive and emotional decision making and value-based learning. In contrast to matrix MSNs, striosomal MSNs receive input from limbic territories, including the anterior cingulate cortex, orbitofrontal cortex, and anterior insular cortex, and project directly to midbrain dopamine neurons."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) [j.cub.2021.10.015](DOI:10.1016/j.cub.2021.10.015)
+#### Added
+- [transcription factor PU.1](http://purl.obolibrary.org/obo/PR_000001944) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [transcription factor PU.1 (human)](http://purl.obolibrary.org/obo/PR_P17947)
-- [striosomal D1 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030048) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "striosome D1-MSN"
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) [j.cub.2021.10.015](DOI:10.1016/j.cub.2021.10.015)
+### transcription factor SOX-2 `http://purl.obolibrary.org/obo/PR_000015426`
-- [striosomal D1 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030048) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "D1S"
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
+#### Added
+- [transcription factor SOX-2](http://purl.obolibrary.org/obo/PR_000015426) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [transcription factor SOX-2 (human)](http://purl.obolibrary.org/obo/PR_P48431)
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) [j.cub.2021.10.015](DOI:10.1016/j.cub.2021.10.015)
-- [striosomal D1 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030048) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "D1-striosome"
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
+### transferrin receptor protein 1 `http://purl.obolibrary.org/obo/PR_000001945`
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "DOI:10.1016/j.cub.2021.10.015"
+#### Added
+- [transferrin receptor protein 1](http://purl.obolibrary.org/obo/PR_000001945) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [transferrin receptor protein 1 (human)](http://purl.obolibrary.org/obo/PR_P02786)
-- Class: [striosomal D1 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030048)
-- [striosomal D1 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030048) SubClassOf [has soma location](http://purl.obolibrary.org/obo/RO_0002100) some
-([striosome](http://purl.obolibrary.org/obo/UBERON_0027371) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [dorsal striatum](http://purl.obolibrary.org/obo/UBERON_0005382)))
+### transit amplifying cell `http://purl.obolibrary.org/obo/CL_0009010`
+#### Removed
+- [transit amplifying cell](http://purl.obolibrary.org/obo/CL_0009010) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [striosomal D1 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030048) SubClassOf [direct pathway medium spiny neuron](http://purl.obolibrary.org/obo/CL_4023026)
-### striosomal D2 medium spiny neuron `http://purl.obolibrary.org/obo/CL_4030049`
+### transmembrane emp24 domain-containing protein 1 `http://purl.obolibrary.org/obo/PR_000016401`
#### Added
-- [striosomal D2 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030049) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "D2-striosome"
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
+- [transmembrane emp24 domain-containing protein 1](http://purl.obolibrary.org/obo/PR_000016401) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [transmembrane emp24 domain-containing protein 1 (human)](http://purl.obolibrary.org/obo/PR_Q13445)
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) [j.cub.2021.10.015](DOI:10.1016/j.cub.2021.10.015)
-- [striosomal D2 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030049) [label](http://www.w3.org/2000/01/rdf-schema#label) "striosomal D2 medium spiny neuron"
+### transudate `http://purl.obolibrary.org/obo/UBERON_0007779`
+#### Removed
+- [transudate](http://purl.obolibrary.org/obo/UBERON_0007779) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [striosomal D2 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030049) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "striosome D2-MSN"
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) [j.cub.2021.10.015](DOI:10.1016/j.cub.2021.10.015)
-- [striosomal D2 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030049) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "striosome D2 medium spiny neuron"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) [j.cub.2021.10.015](DOI:10.1016/j.cub.2021.10.015)
+### transverse colon `http://purl.obolibrary.org/obo/UBERON_0001157`
+#### Removed
+- [transverse colon](http://purl.obolibrary.org/obo/UBERON_0001157) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [striosomal D2 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030049) [date](http://purl.org/dc/terms/date) "2023-06-02T15:03:08Z"^^[dateTime](http://www.w3.org/2001/XMLSchema#dateTime)
-- [striosomal D2 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030049) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "D2S"
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) [j.cub.2021.10.015](DOI:10.1016/j.cub.2021.10.015)
+### trigeminal nerve `http://purl.obolibrary.org/obo/UBERON_0001645`
+#### Removed
+- [trigeminal nerve](http://purl.obolibrary.org/obo/UBERON_0001645) SubClassOf [neuron projection bundle](http://purl.obolibrary.org/obo/CARO_0001001)
-- [striosomal D2 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030049) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "In Rhesus macaques, both striosomal D1 and D2 medium spiny neuron (MSN) cell types have been noted to have enriched gene expression of the following: KCNT1, KHDRBS3, FAM163A, BACH2, and KCNIP1. Striosomal MSN activations have been noted to influence cognitive and emotional decision making and value-based learning. In contrast to matrix MSNs, striosomal MSNs receive input from limbic territories, including the anterior cingulate cortex, orbitofrontal cortex, and anterior insular cortex, and project directly to midbrain dopamine neurons."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) [j.cub.2021.10.015](DOI:10.1016/j.cub.2021.10.015)
-- [striosomal D2 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030049) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A DRD2-expressing medium spiny neuron that is part of a striosome of dorsal striatum."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) [j.cub.2021.10.015](DOI:10.1016/j.cub.2021.10.015)
-- Class: [striosomal D2 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030049)
+### trophectoderm `http://purl.obolibrary.org/obo/UBERON_0004345`
+#### Removed
+- [trophectoderm](http://purl.obolibrary.org/obo/UBERON_0004345) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [striosomal D2 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030049) SubClassOf [indirect pathway medium spiny neuron](http://purl.obolibrary.org/obo/CL_4023029)
-- [striosomal D2 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030049) SubClassOf [has soma location](http://purl.obolibrary.org/obo/RO_0002100) some
-([striosome](http://purl.obolibrary.org/obo/UBERON_0027371) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [dorsal striatum](http://purl.obolibrary.org/obo/UBERON_0005382)))
+### trophoblast `http://purl.obolibrary.org/obo/UBERON_0000088`
+#### Removed
+- [trophoblast](http://purl.obolibrary.org/obo/UBERON_0000088) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-### striosomal part of caudate nucleus `http://purl.obolibrary.org/obo/UBERON_0029004`
-#### Added
-- [striosomal part of caudate nucleus](http://purl.obolibrary.org/obo/UBERON_0029004) [label](http://www.w3.org/2000/01/rdf-schema#label) "striosomal part of caudate nucleus"
-- [striosomal part of caudate nucleus](http://purl.obolibrary.org/obo/UBERON_0029004) [id](http://www.geneontology.org/formats/oboInOwl#id) "UBERON:0029004"
+### trunk neural crest `http://purl.obolibrary.org/obo/UBERON_0003083`
+#### Removed
+- [trunk neural crest](http://purl.obolibrary.org/obo/UBERON_0003083) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
-- [striosomal part of caudate nucleus](http://purl.obolibrary.org/obo/UBERON_0029004) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "NLXANAT:20090507"
-- [striosomal part of caudate nucleus](http://purl.obolibrary.org/obo/UBERON_0029004) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "striosomal part of caudate nucleus"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "NLXANAT:20090507"
+### tubotympanic recess lumen `http://purl.obolibrary.org/obo/UBERON_0005625`
+#### Removed
+- [tubotympanic recess lumen](http://purl.obolibrary.org/obo/UBERON_0005625) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [striosomal part of caudate nucleus](http://purl.obolibrary.org/obo/UBERON_0029004) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "uberon"
-- Class: [striosomal part of caudate nucleus](http://purl.obolibrary.org/obo/UBERON_0029004)
-- [striosomal part of caudate nucleus](http://purl.obolibrary.org/obo/UBERON_0029004) EquivalentTo [striosome](http://purl.obolibrary.org/obo/UBERON_0027371) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [caudate nucleus](http://purl.obolibrary.org/obo/UBERON_0001873))
+### tumor necrosis factor receptor superfamily member 11A `http://purl.obolibrary.org/obo/PR_000001954`
-- [striosomal part of caudate nucleus](http://purl.obolibrary.org/obo/UBERON_0029004) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [caudate nucleus](http://purl.obolibrary.org/obo/UBERON_0001873)
+#### Added
+- [tumor necrosis factor receptor superfamily member 11A](http://purl.obolibrary.org/obo/PR_000001954) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [tumor necrosis factor receptor superfamily member 11A (human)](http://purl.obolibrary.org/obo/PR_Q9Y6Q6)
-- [striosomal part of caudate nucleus](http://purl.obolibrary.org/obo/UBERON_0029004) SubClassOf [striosome](http://purl.obolibrary.org/obo/UBERON_0027371)
+### tunica adventitia of artery `http://purl.obolibrary.org/obo/UBERON_0007240`
+#### Removed
+- [tunica adventitia of artery](http://purl.obolibrary.org/obo/UBERON_0007240) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-### striosomal part of putamen `http://purl.obolibrary.org/obo/UBERON_0029005`
-#### Added
-- [striosomal part of putamen](http://purl.obolibrary.org/obo/UBERON_0029005) [label](http://www.w3.org/2000/01/rdf-schema#label) "striosomal part of putamen"
-- [striosomal part of putamen](http://purl.obolibrary.org/obo/UBERON_0029005) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "NLXANAT:20090508"
+### tunica fibrosa of eyeball `http://purl.obolibrary.org/obo/UBERON_0012430`
+#### Removed
+- [tunica fibrosa of eyeball](http://purl.obolibrary.org/obo/UBERON_0012430) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-- [striosomal part of putamen](http://purl.obolibrary.org/obo/UBERON_0029005) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "uberon"
-- [striosomal part of putamen](http://purl.obolibrary.org/obo/UBERON_0029005) [id](http://www.geneontology.org/formats/oboInOwl#id) "UBERON:0029005"
-- [striosomal part of putamen](http://purl.obolibrary.org/obo/UBERON_0029005) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "striosomal part of putamen"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "NLXANAT:20090508"
+### tunica intima `http://purl.obolibrary.org/obo/UBERON_0002523`
+#### Removed
+- [tunica intima](http://purl.obolibrary.org/obo/UBERON_0002523) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- Class: [striosomal part of putamen](http://purl.obolibrary.org/obo/UBERON_0029005)
-- [striosomal part of putamen](http://purl.obolibrary.org/obo/UBERON_0029005) EquivalentTo [striosome](http://purl.obolibrary.org/obo/UBERON_0027371) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [putamen](http://purl.obolibrary.org/obo/UBERON_0001874))
-- [striosomal part of putamen](http://purl.obolibrary.org/obo/UBERON_0029005) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [putamen](http://purl.obolibrary.org/obo/UBERON_0001874)
+### tunica media `http://purl.obolibrary.org/obo/UBERON_0002522`
+#### Removed
+- [tunica media](http://purl.obolibrary.org/obo/UBERON_0002522) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [striosomal part of putamen](http://purl.obolibrary.org/obo/UBERON_0029005) SubClassOf [striosome](http://purl.obolibrary.org/obo/UBERON_0027371)
-### striosome `http://purl.obolibrary.org/obo/UBERON_0027371`
+### type 1 spiral ganglion neuron `http://purl.obolibrary.org/obo/CL_4023115`
+#### Removed
+- [type 1 spiral ganglion neuron](http://purl.obolibrary.org/obo/CL_4023115) SubClassOf [neuron projection bundle](http://purl.obolibrary.org/obo/CARO_0001001)
#### Added
-- [striosome](http://purl.obolibrary.org/obo/UBERON_0027371) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "striosome"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "NLXANAT:20090506"
+- [type 1 spiral ganglion neuron](http://purl.obolibrary.org/obo/CL_4023115) SubClassOf [neuron projection bundle](http://purl.obolibrary.org/obo/UBERON_0000122)
-- [striosome](http://purl.obolibrary.org/obo/UBERON_0027371) [id](http://www.geneontology.org/formats/oboInOwl#id) "UBERON:0027371"
-- [striosome](http://purl.obolibrary.org/obo/UBERON_0027371) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "One of two compartments identified in the neostriatum, particularly the caudate nucleus, on the basis of differential staining for several biochemical markers such as acetylcholinesterase and calbindin. In individual sections, the striosomes appear as small patches of differentially high or low staining activity. In three dimensions, they form a 3D labyrinth extending throughout the caudate nucleus and in the putamen."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "NLXANAT:20090506"
+### type 2 spiral ganglion neuron `http://purl.obolibrary.org/obo/CL_4023116`
+#### Removed
+- [type 2 spiral ganglion neuron](http://purl.obolibrary.org/obo/CL_4023116) SubClassOf [neuron projection bundle](http://purl.obolibrary.org/obo/CARO_0001001)
-- [striosome](http://purl.obolibrary.org/obo/UBERON_0027371) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "striosomal part"
+#### Added
+- [type 2 spiral ganglion neuron](http://purl.obolibrary.org/obo/CL_4023116) SubClassOf [neuron projection bundle](http://purl.obolibrary.org/obo/UBERON_0000122)
-- [striosome](http://purl.obolibrary.org/obo/UBERON_0027371) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "NLXANAT:20090506"
-- [striosome](http://purl.obolibrary.org/obo/UBERON_0027371) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "striosomal compartment"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "NLXANAT:20090506"
+### type II pneumocyte `http://purl.obolibrary.org/obo/CL_0002063`
+#### Removed
+- [type II pneumocyte](http://purl.obolibrary.org/obo/CL_0002063) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [striosome](http://purl.obolibrary.org/obo/UBERON_0027371) [label](http://www.w3.org/2000/01/rdf-schema#label) "striosome"
-- [striosome](http://purl.obolibrary.org/obo/UBERON_0027371) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "uberon"
-- Class: [striosome](http://purl.obolibrary.org/obo/UBERON_0027371)
+### tyrosine-protein kinase Mer `http://purl.obolibrary.org/obo/PR_000010329`
-- [striosome](http://purl.obolibrary.org/obo/UBERON_0027371) SubClassOf [chemoarchitectural part of striatum](http://purl.obolibrary.org/obo/UBERON_0025736)
- - [source](http://www.geneontology.org/formats/oboInOwl#source) "NIFSTD"
+#### Added
+- [tyrosine-protein kinase Mer](http://purl.obolibrary.org/obo/PR_000010329) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [tyrosine-protein kinase Mer (human)](http://purl.obolibrary.org/obo/PR_Q12866)
-### stromal cell `http://purl.obolibrary.org/obo/CL_0000499`
+### tyrosine-protein kinase receptor UFO `http://purl.obolibrary.org/obo/PR_000004528`
#### Added
-- [stromal cell](http://purl.obolibrary.org/obo/CL_0000499) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [general_cell_types_upper_slim](http://purl.obolibrary.org/obo/cl#general_cell_types_upper_slim)
+- [tyrosine-protein kinase receptor UFO](http://purl.obolibrary.org/obo/PR_000004528) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [tyrosine-protein kinase receptor UFO (human)](http://purl.obolibrary.org/obo/PR_P30530)
-### stromal cell of thymus `http://purl.obolibrary.org/obo/CL_4030001`
-#### Removed
-- [stromal cell of thymus](http://purl.obolibrary.org/obo/CL_4030001) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A stromal cell that is part of the thymus."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) [s41467-020-20082-7](https://www.nature.com/articles/s41467-020-20082-7)
+### tyrosine-protein phosphatase non-receptor type substrate 1 `http://purl.obolibrary.org/obo/PR_000001968`
#### Added
-- [stromal cell of thymus](http://purl.obolibrary.org/obo/CL_4030001) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A stromal cell that is part of the thymus."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1038/s41467-020-20082-7"
+- [tyrosine-protein phosphatase non-receptor type substrate 1](http://purl.obolibrary.org/obo/PR_000001968) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [tyrosine-protein phosphatase non-receptor type substrate 1 (human)](http://purl.obolibrary.org/obo/PR_P78324)
-### submucosal gland acinus `http://purl.obolibrary.org/obo/UBERON_8600012`
+### umbilical cord `http://purl.obolibrary.org/obo/UBERON_0002331`
+#### Removed
+- [umbilical cord](http://purl.obolibrary.org/obo/UBERON_0002331) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-#### Added
-- [submucosal gland acinus](http://purl.obolibrary.org/obo/UBERON_8600012) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A spherical or tubular structure in a submucosal gland that produces and secretes mucus and other substances into the ducts leading to the surface epithelium."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:17394068"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:30864819"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:17707699"
+### uncurated `http://purl.obolibrary.org/obo/IAO_0000124`
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:25648514"
+#### Added
+- [uncurated](http://purl.obolibrary.org/obo/IAO_0000124) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Nothing done yet beyond assigning a unique class ID and proposing a preferred term."@en
-- [submucosal gland acinus](http://purl.obolibrary.org/obo/UBERON_8600012) [id](http://www.geneontology.org/formats/oboInOwl#id) "UBERON:8600012"
+- [uncurated](http://purl.obolibrary.org/obo/IAO_0000124) [label](http://www.w3.org/2000/01/rdf-schema#label) "uncurated"@en
-- [submucosal gland acinus](http://purl.obolibrary.org/obo/UBERON_8600012) [date](http://purl.org/dc/terms/date) "2023-05-02T08:57:27Z"^^[dateTime](http://www.w3.org/2001/XMLSchema#dateTime)
+- [uncurated](http://purl.obolibrary.org/obo/IAO_0000124) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "uncurated"@en
-- [submucosal gland acinus](http://purl.obolibrary.org/obo/UBERON_8600012) [label](http://www.w3.org/2000/01/rdf-schema#label) "submucosal gland acinus"
+- Individual: [uncurated](http://purl.obolibrary.org/obo/IAO_0000124)
-- [submucosal gland acinus](http://purl.obolibrary.org/obo/UBERON_8600012) [contributor](http://purl.org/dc/terms/contributor) [0000-0001-6677-8489](https://orcid.org/0000-0001-6677-8489)
-- [submucosal gland acinus](http://purl.obolibrary.org/obo/UBERON_8600012) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "uberon"
+### undifferentiated genital tubercle `http://purl.obolibrary.org/obo/UBERON_0005876`
+#### Removed
+- [undifferentiated genital tubercle](http://purl.obolibrary.org/obo/UBERON_0005876) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- Class: [submucosal gland acinus](http://purl.obolibrary.org/obo/UBERON_8600012)
-- [submucosal gland acinus](http://purl.obolibrary.org/obo/UBERON_8600012) EquivalentTo [glandular acinus](http://purl.obolibrary.org/obo/UBERON_0009842) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [submucosal gland](http://purl.obolibrary.org/obo/UBERON_0011148))
-- [submucosal gland acinus](http://purl.obolibrary.org/obo/UBERON_8600012) SubClassOf [mucous acinus](http://purl.obolibrary.org/obo/UBERON_0014717)
+### unipolar brush cell `http://purl.obolibrary.org/obo/CL_4023161`
+#### Removed
+- [unipolar brush cell](http://purl.obolibrary.org/obo/CL_4023161) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [submucosal gland acinus](http://purl.obolibrary.org/obo/UBERON_8600012) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [submucosal gland](http://purl.obolibrary.org/obo/UBERON_0011148)
-### term tracker item `http://purl.obolibrary.org/obo/IAO_0000233`
+### universal `http://purl.obolibrary.org/obo/IAO_0000410`
#### Added
-- [term tracker item](http://purl.obolibrary.org/obo/IAO_0000233) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "uberon"
+- [universal](http://purl.obolibrary.org/obo/IAO_0000410) [IAO_0000117](http://purl.obolibrary.org/obo/IAO_0000117) "Alan Ruttenberg"@en
+- [universal](http://purl.obolibrary.org/obo/IAO_0000410) [label](http://www.w3.org/2000/01/rdf-schema#label) "universal"@en
-### term_scheduled_for_obsoletion `http://purl.obolibrary.org/obo/go#term_scheduled_for_obsoletion`
-#### Removed
-- AnnotationProperty: [term_scheduled_for_obsoletion](http://purl.obolibrary.org/obo/go#term_scheduled_for_obsoletion)
+- [universal](http://purl.obolibrary.org/obo/IAO_0000410) [IAO_0000119](http://purl.obolibrary.org/obo/IAO_0000119) "A Formal Theory of Substances, Qualities, and Universals, http://ontology.buffalo.edu/bfo/SQU.pdf"@en
+
+- [universal](http://purl.obolibrary.org/obo/IAO_0000410) [editor note](http://purl.obolibrary.org/obo/IAO_0000116) "Hard to give a definition for. Intuitively a "natural kind" rather than a collection of any old things, which a class is able to be, formally. At the meta level, universals are defined as positives, are disjoint with their siblings, have single asserted parents."@en
-- [term_scheduled_for_obsoletion](http://purl.obolibrary.org/obo/go#term_scheduled_for_obsoletion) SubPropertyOf: [subset_property](http://www.geneontology.org/formats/oboInOwl#SubsetProperty)
+- [universal](http://purl.obolibrary.org/obo/IAO_0000410) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "universal"@en
+- Individual: [universal](http://purl.obolibrary.org/obo/IAO_0000410)
-### trachea blood vessel `http://purl.obolibrary.org/obo/UBERON_0003505`
+### upper arm epithelium `http://purl.obolibrary.org/obo/UBERON_0005228`
#### Removed
-- [trachea blood vessel](http://purl.obolibrary.org/obo/UBERON_0003505) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [human_reference_atlas](http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas)
+- [upper arm epithelium](http://purl.obolibrary.org/obo/UBERON_0005228) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [trachea blood vessel](http://purl.obolibrary.org/obo/UBERON_0003505) [present_in_taxon](http://purl.obolibrary.org/obo/RO_0002175) [Homo sapiens](http://purl.obolibrary.org/obo/NCBITaxon_9606)
+### upper digestive tract `http://purl.obolibrary.org/obo/UBERON_0004908`
+#### Removed
+- [upper digestive tract](http://purl.obolibrary.org/obo/UBERON_0004908) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-### type II pneumocyte `http://purl.obolibrary.org/obo/CL_0002063`
-#### Added
-- [type II pneumocyte](http://purl.obolibrary.org/obo/CL_0002063) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [type II pneumocyte](http://purl.obolibrary.org/obo/CL_0002063) SubClassOf [develops from](http://purl.obolibrary.org/obo/RO_0002202) some [fetal pre-type II pneumocyte](http://purl.obolibrary.org/obo/CL_4040003)
+### upper jaw region `http://purl.obolibrary.org/obo/UBERON_0001709`
+#### Removed
+- [upper jaw region](http://purl.obolibrary.org/obo/UBERON_0001709) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000)
+
-### ubiquitin-like protein conjugating enzyme activity `http://purl.obolibrary.org/obo/GO_0061650`
+### upper leg epithelium `http://purl.obolibrary.org/obo/UBERON_0005225`
#### Removed
-- [ubiquitin-like protein conjugating enzyme activity](http://purl.obolibrary.org/obo/GO_0061650) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "E2"
+- [upper leg epithelium](http://purl.obolibrary.org/obo/UBERON_0005225) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [ubiquitin-like protein conjugating enzyme activity](http://purl.obolibrary.org/obo/GO_0061650) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Isoenergetic transfer of a ubiquitin-like protein (ULP) from one protein to another via the reaction X-SCP + Y -> Y-SCP + X, where both the X-SCP and Y-SCP linkages are thioester bonds between the C-terminal amino acid of SCP and a sulfhydryl side group of a cysteine residue."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dph"
-#### Added
-- [ubiquitin-like protein conjugating enzyme activity](http://purl.obolibrary.org/obo/GO_0061650) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "E2"
-- [ubiquitin-like protein conjugating enzyme activity](http://purl.obolibrary.org/obo/GO_0061650) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Isoenergetic transfer of a ubiquitin-like protein (ULP) from one protein to another via the reaction X-SCP + Y = Y-SCP + X, where both the X-SCP and Y-SCP linkages are thioester bonds between the C-terminal amino acid of SCP and a sulfhydryl side group of a cysteine residue."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dph"
+### upper lip `http://purl.obolibrary.org/obo/UBERON_0001834`
+#### Removed
+- [upper lip](http://purl.obolibrary.org/obo/UBERON_0001834) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-### ubiquitin-like protein ligase activity `http://purl.obolibrary.org/obo/GO_0061659`
+
+### upper motor neuron `http://purl.obolibrary.org/obo/CL_0008048`
#### Removed
-- [ubiquitin-like protein ligase activity](http://purl.obolibrary.org/obo/GO_0061659) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Catalysis of the transfer of a ubiquitin-like protein (ULP) to a substrate protein via the reaction X-ULP + S --> X + S-ULP, where X is either an E2 or E3 enzyme, the X-ULP linkage is a thioester bond, and the S-ULP linkage is an isopeptide bond between the C-terminal glycine of ULP and the epsilon-amino group of lysine residues in the substrate."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dph"
+- [upper motor neuron](http://purl.obolibrary.org/obo/CL_0008048) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-#### Added
-- [ubiquitin-like protein ligase activity](http://purl.obolibrary.org/obo/GO_0061659) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Catalysis of the transfer of a ubiquitin-like protein (ULP) to a substrate protein via the reaction X-ULP + S = X + S-ULP, where X is either an E2 or E3 enzyme, the X-ULP linkage is a thioester bond, and the S-ULP linkage is an isopeptide bond between the C-terminal glycine of ULP and the epsilon-amino group of lysine residues in the substrate."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dph"
-### ubiquitin-like protein peptidase activity `http://purl.obolibrary.org/obo/GO_0019783`
+### upper respiratory tract `http://purl.obolibrary.org/obo/UBERON_0001557`
#### Removed
-- [ubiquitin-like protein peptidase activity](http://purl.obolibrary.org/obo/GO_0019783) [has_alternative_id](http://www.geneontology.org/formats/oboInOwl#hasAlternativeId) "GO:1904455"
+- [upper respiratory tract](http://purl.obolibrary.org/obo/UBERON_0001557) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-- [ubiquitin-like protein peptidase activity](http://purl.obolibrary.org/obo/GO_0019783) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "small conjugating protein-specific isopeptidase activity"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dph"
-- [ubiquitin-like protein peptidase activity](http://purl.obolibrary.org/obo/GO_0019783) [has_alternative_id](http://www.geneontology.org/formats/oboInOwl#hasAlternativeId) "GO:1904454"
-- [ubiquitin-like protein peptidase activity](http://purl.obolibrary.org/obo/GO_0019783) [has_alternative_id](http://www.geneontology.org/formats/oboInOwl#hasAlternativeId) "GO:0140491"
+### upper rhombic lip `http://purl.obolibrary.org/obo/UBERON_0009841`
-- [ubiquitin-like protein peptidase activity](http://purl.obolibrary.org/obo/GO_0019783) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "ubiquitin-like hydrolase activity"
+#### Added
+- [upper rhombic lip](http://purl.obolibrary.org/obo/UBERON_0009841) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "uberon"
-- [ubiquitin-like protein peptidase activity](http://purl.obolibrary.org/obo/GO_0019783) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "molecular_function"
+- [upper rhombic lip](http://purl.obolibrary.org/obo/UBERON_0009841) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "TAO:0001442"
-- [ubiquitin-like protein peptidase activity](http://purl.obolibrary.org/obo/GO_0019783) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "An isopeptidase activity that cleaves ubiquitin or ubiquitin-like proteins (ULP; e.g. ATG8, ISG15, NEDD8, SUMO) from target proteins."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:19489724"
+- [upper rhombic lip](http://purl.obolibrary.org/obo/UBERON_0009841) [label](http://www.w3.org/2000/01/rdf-schema#label) "upper rhombic lip"
-- [ubiquitin-like protein peptidase activity](http://purl.obolibrary.org/obo/GO_0019783) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "ubiquitin-specific protease activity involved in negative regulation of ERAD pathway"
+- [upper rhombic lip](http://purl.obolibrary.org/obo/UBERON_0009841) [id](http://www.geneontology.org/formats/oboInOwl#id) "UBERON:0009841"
-- [ubiquitin-like protein peptidase activity](http://purl.obolibrary.org/obo/GO_0019783) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "ubiquitin-like protein-specific protease activity"
+- [upper rhombic lip](http://purl.obolibrary.org/obo/UBERON_0009841) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ZFA:0001442"
-- [ubiquitin-like protein peptidase activity](http://purl.obolibrary.org/obo/GO_0019783) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "ubiquitin-like-protein-specific protease activity"
+- [upper rhombic lip](http://purl.obolibrary.org/obo/UBERON_0009841) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Anterior-most region of dorsal hindbrain within rhombomere 1, adjacent the midbrain-hindbrain boundary."
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ZFIN:curator"
-- [ubiquitin-like protein peptidase activity](http://purl.obolibrary.org/obo/GO_0019783) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "ubiquitinyl-like hydrolase activity"
+- [upper rhombic lip](http://purl.obolibrary.org/obo/UBERON_0009841) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "upper (rostral) rhombic lip"
-- [ubiquitin-like protein peptidase activity](http://purl.obolibrary.org/obo/GO_0019783) [term tracker item](http://purl.obolibrary.org/obo/IAO_0000233) "https://github.com/geneontology/go-ontology/issues/17398"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI)
+- [upper rhombic lip](http://purl.obolibrary.org/obo/UBERON_0009841) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "presumptive cerebellum"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ZFA:0001442"
-- [ubiquitin-like protein peptidase activity](http://purl.obolibrary.org/obo/GO_0019783) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "ubiquitin-like specific protease activity"
+- [upper rhombic lip](http://purl.obolibrary.org/obo/UBERON_0009841) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "rhombomere 01 cerebellum primordium"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "EHDAA2:0000229"
-- [ubiquitin-like protein peptidase activity](http://purl.obolibrary.org/obo/GO_0019783) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "ubiquitin-like protein-specific isopeptidase activity"
+- [upper rhombic lip](http://purl.obolibrary.org/obo/UBERON_0009841) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "DHBA:10665"
-- [ubiquitin-like protein peptidase activity](http://purl.obolibrary.org/obo/GO_0019783) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "While ubiquitin-like proteins can be rarely linked to substrates via bonds other than isopeptide bonds, all known ubiquitin-like peptidases cleave the isopeptide bond."
+- [upper rhombic lip](http://purl.obolibrary.org/obo/UBERON_0009841) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "EHDAA2:0000229"
-- [ubiquitin-like protein peptidase activity](http://purl.obolibrary.org/obo/GO_0019783) [has_alternative_id](http://www.geneontology.org/formats/oboInOwl#hasAlternativeId) "GO:0070138"
+- [upper rhombic lip](http://purl.obolibrary.org/obo/UBERON_0009841) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "rostral rhombic lip"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "DHB:URL"
-- [ubiquitin-like protein peptidase activity](http://purl.obolibrary.org/obo/GO_0019783) [label](http://www.w3.org/2000/01/rdf-schema#label) "ubiquitin-like protein peptidase activity"
+- [upper rhombic lip](http://purl.obolibrary.org/obo/UBERON_0009841) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [pheno_slim](http://purl.obolibrary.org/obo/uberon/core#pheno_slim)
-- [ubiquitin-like protein peptidase activity](http://purl.obolibrary.org/obo/GO_0019783) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "small conjugating protein-specific protease activity"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dph"
+- [upper rhombic lip](http://purl.obolibrary.org/obo/UBERON_0009841) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "cerebellar anlage"
+ - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ZFA:0001442"
-- [ubiquitin-like protein peptidase activity](http://purl.obolibrary.org/obo/GO_0019783) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "ubiquitin-specific protease activity involved in positive regulation of ERAD pathway"
+- Class: [upper rhombic lip](http://purl.obolibrary.org/obo/UBERON_0009841)
-- [ubiquitin-like protein peptidase activity](http://purl.obolibrary.org/obo/GO_0019783) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0019783"
+- [upper rhombic lip](http://purl.obolibrary.org/obo/UBERON_0009841) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [rhombic lip](http://purl.obolibrary.org/obo/UBERON_0006215)
+ - [source](http://www.geneontology.org/formats/oboInOwl#source) "ZFA"
-- Class: [ubiquitin-like protein peptidase activity](http://purl.obolibrary.org/obo/GO_0019783)
+- [upper rhombic lip](http://purl.obolibrary.org/obo/UBERON_0009841) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [rhombomere 1](http://purl.obolibrary.org/obo/UBERON_0005499)
+ - [source](http://www.geneontology.org/formats/oboInOwl#source) "ZFA"
-- [ubiquitin-like protein peptidase activity](http://purl.obolibrary.org/obo/GO_0019783) SubClassOf [peptidase activity](http://purl.obolibrary.org/obo/GO_0008233)
+- [upper rhombic lip](http://purl.obolibrary.org/obo/UBERON_0009841) SubClassOf [adjacent to](http://purl.obolibrary.org/obo/RO_0002220) some [midbrain-hindbrain boundary](http://purl.obolibrary.org/obo/UBERON_0003052)
+ - [source](http://www.geneontology.org/formats/oboInOwl#source) "ZFA-def"
+- [upper rhombic lip](http://purl.obolibrary.org/obo/UBERON_0009841) SubClassOf [regional part of brain](http://purl.obolibrary.org/obo/UBERON_0002616)
-### ubiquitin-like protein transferase activity `http://purl.obolibrary.org/obo/GO_0019787`
+### upper urinary tract `http://purl.obolibrary.org/obo/UBERON_0011143`
#### Removed
-- [ubiquitin-like protein transferase activity](http://purl.obolibrary.org/obo/GO_0019787) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Catalysis of the transfer of a ubiquitin-like from one protein to another via the reaction X-ULP + Y --> Y-ULP + X, where both X-ULP and Y-ULP are covalent linkages. ULP represents a ubiquitin-like protein."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:mah"
+- [upper urinary tract](http://purl.obolibrary.org/obo/UBERON_0011143) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:10806345"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:10884686"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:rn"
+### ureteric bud `http://purl.obolibrary.org/obo/UBERON_0000084`
+#### Removed
+- [ureteric bud](http://purl.obolibrary.org/obo/UBERON_0000084) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-- [ubiquitin-like protein transferase activity](http://purl.obolibrary.org/obo/GO_0019787) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "E2"
-#### Added
-- [ubiquitin-like protein transferase activity](http://purl.obolibrary.org/obo/GO_0019787) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Catalysis of the transfer of a ubiquitin-like from one protein to another via the reaction X-ULP + Y = Y-ULP + X, where both X-ULP and Y-ULP are covalent linkages. ULP represents a ubiquitin-like protein."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:mah"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:10806345"
+### uriniferous tubule `http://purl.obolibrary.org/obo/UBERON_0007684`
+#### Removed
+- [uriniferous tubule](http://purl.obolibrary.org/obo/UBERON_0007684) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:10884686"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:rn"
-- [ubiquitin-like protein transferase activity](http://purl.obolibrary.org/obo/GO_0019787) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "E2"
+### urogenital sinus lumen `http://purl.obolibrary.org/obo/UBERON_0009844`
+#### Removed
+- [urogenital sinus lumen](http://purl.obolibrary.org/obo/UBERON_0009844) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [ubiquitin-like protein transferase activity](http://purl.obolibrary.org/obo/GO_0019787) SubClassOf [catalytic activity, acting on a protein](http://purl.obolibrary.org/obo/GO_0140096)
-### umbrella cell of urothelium `http://purl.obolibrary.org/obo/CL_4030056`
+### urokinase plasminogen activator surface receptor `http://purl.obolibrary.org/obo/PR_000001969`
#### Added
-- [umbrella cell of urothelium](http://purl.obolibrary.org/obo/CL_4030056) [label](http://www.w3.org/2000/01/rdf-schema#label) "umbrella cell of urothelium"
+- [urokinase plasminogen activator surface receptor](http://purl.obolibrary.org/obo/PR_000001969) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [urokinase plasminogen activator surface receptor (human)](http://purl.obolibrary.org/obo/PR_Q03405)
-- [umbrella cell of urothelium](http://purl.obolibrary.org/obo/CL_4030056) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A urothelial cell that is terminally differentiated and part of the urothelial apical surface that forms the high-resistance barrier of urothelium. Umbrella cells have been described as the largest of urothelial cell types, highly polarized, and, in some species, multinucleated. In the relaxed state, these cells form a dome-shaped structure at the apical pole and can also cover multiple underlying intermediate cells, leading to the name umbrella cells. In contrast, these cells flatten when the bladder is filled."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1038/s41385-022-00565-0"
-- [umbrella cell of urothelium](http://purl.obolibrary.org/obo/CL_4030056) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "FMA:84149"
+### uteroglobin `http://purl.obolibrary.org/obo/PR_000014505`
-- [umbrella cell of urothelium](http://purl.obolibrary.org/obo/CL_4030056) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "Umbrella cells are attached to sub-superficial cell layers via desmosomes, while tight junctions localized between superficial cells aid in forming a high-resistance barrier function. Another distinguishing feature of an umbrella cell type is the presence of subapical discoidal/fusiform-shaped vesicles contributing to the plasticity in urothelial cell surface area through a regulated process of endocytosis/exocytosis. It has been noted in at least some mammalian species that the urothelial umbrella cell type expresses UPK1A, UPK1B, UPK2 and UPK3A. Unlike intermediate and basal cells of the urothelium, CK17 is reported to be completely absent and p63 not expressed in umbrella cells."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1038/s41385-022-00565-0"
+#### Added
+- [uteroglobin](http://purl.obolibrary.org/obo/PR_000014505) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [uteroglobin (human)](http://purl.obolibrary.org/obo/PR_P11684)
-- [umbrella cell of urothelium](http://purl.obolibrary.org/obo/CL_4030056) [date](http://purl.org/dc/terms/date) "2023-06-16T07:59:43Z"^^[dateTime](http://www.w3.org/2001/XMLSchema#dateTime)
-- [umbrella cell of urothelium](http://purl.obolibrary.org/obo/CL_4030056) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "facet cell of urothelium"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1038/s41385-022-00565-0"
+### uterus `http://purl.obolibrary.org/obo/UBERON_0000995`
+#### Removed
+- [uterus](http://purl.obolibrary.org/obo/UBERON_0000995) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [umbrella cell of urothelium](http://purl.obolibrary.org/obo/CL_4030056) [contributor](http://purl.org/dc/terms/contributor) "https://orcid.org/0000-0003-3065-9183"
-- [umbrella cell of urothelium](http://purl.obolibrary.org/obo/CL_4030056) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "superficial cell of urothelium"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1038/s41385-022-00565-0"
-- Class: [umbrella cell of urothelium](http://purl.obolibrary.org/obo/CL_4030056)
+### uvea `http://purl.obolibrary.org/obo/UBERON_0001768`
+#### Removed
+- [uvea](http://purl.obolibrary.org/obo/UBERON_0001768) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-- [umbrella cell of urothelium](http://purl.obolibrary.org/obo/CL_4030056) SubClassOf [urothelial cell](http://purl.obolibrary.org/obo/CL_0000731)
-### urothelial cell `http://purl.obolibrary.org/obo/CL_0000731`
+### vascular cord `http://purl.obolibrary.org/obo/UBERON_0006965`
#### Removed
-- [urothelial cell](http://purl.obolibrary.org/obo/CL_0000731) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "transitional epithelial cell of urinary bladder"
+- [vascular cord](http://purl.obolibrary.org/obo/UBERON_0006965) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-- [urothelial cell](http://purl.obolibrary.org/obo/CL_0000731) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "bladder transitional cell"
-
-- [urothelial cell](http://purl.obolibrary.org/obo/CL_0000731) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A cell of a layer of transitional epithelium in the wall of the bladder, ureter, and renal pelvis, external to the lamina propria."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:tfm"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "MA:ma"
-- [urothelial cell](http://purl.obolibrary.org/obo/CL_0000731) SubClassOf [transitional epithelial cell](http://purl.obolibrary.org/obo/CL_0000244)
- - [is_inferred](http://www.geneontology.org/formats/oboInOwl#is_inferred) "true"
+### vascular endothelial growth factor receptor 2 `http://purl.obolibrary.org/obo/PR_000002112`
#### Added
-- [urothelial cell](http://purl.obolibrary.org/obo/CL_0000731) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A cell of a layer of transitional epithelium in the wall of the proximal urethra, bladder, ureter or renal pelvis, external to the lamina propria."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:tfm"
+- [vascular endothelial growth factor receptor 2](http://purl.obolibrary.org/obo/PR_000002112) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [vascular endothelial growth factor receptor 2 (human)](http://purl.obolibrary.org/obo/PR_P35968)
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "MA:ma"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1038/s41385-022-00565-0"
+### vascular plexus `http://purl.obolibrary.org/obo/UBERON_0005629`
+#### Removed
+- [vascular plexus](http://purl.obolibrary.org/obo/UBERON_0005629) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [urothelial cell](http://purl.obolibrary.org/obo/CL_0000731) SubClassOf [transitional epithelial cell](http://purl.obolibrary.org/obo/CL_0000244)
-### urothelial cell of trigone of urinary bladder `http://purl.obolibrary.org/obo/CL_1000442`
+### vasculature of eye `http://purl.obolibrary.org/obo/UBERON_0002203`
#### Removed
-- [urothelial cell of trigone of urinary bladder](http://purl.obolibrary.org/obo/CL_1000442) EquivalentTo [urothelial cell](http://purl.obolibrary.org/obo/CL_0000731) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [trigone of urinary bladder](http://purl.obolibrary.org/obo/UBERON_0001257))
+- [vasculature of eye](http://purl.obolibrary.org/obo/UBERON_0002203) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [urothelial cell of trigone of urinary bladder](http://purl.obolibrary.org/obo/CL_1000442) SubClassOf [bladder cell](http://purl.obolibrary.org/obo/CL_1001319)
-- [urothelial cell of trigone of urinary bladder](http://purl.obolibrary.org/obo/CL_1000442) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [trigone of urinary bladder](http://purl.obolibrary.org/obo/UBERON_0001257)
-- [urothelial cell of trigone of urinary bladder](http://purl.obolibrary.org/obo/CL_1000442) SubClassOf [urothelial cell](http://purl.obolibrary.org/obo/CL_0000731)
- - [is_inferred](http://www.geneontology.org/formats/oboInOwl#is_inferred) "true"
+### venous system `http://purl.obolibrary.org/obo/UBERON_0004582`
+#### Removed
+- [venous system](http://purl.obolibrary.org/obo/UBERON_0004582) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-#### Added
-- [urothelial cell of trigone of urinary bladder](http://purl.obolibrary.org/obo/CL_1000442) EquivalentTo [urothelial cell](http://purl.obolibrary.org/obo/CL_0000731) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some
-([urothelium](http://purl.obolibrary.org/obo/UBERON_0000365) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [trigone of urinary bladder](http://purl.obolibrary.org/obo/UBERON_0001257))))
-- [urothelial cell of trigone of urinary bladder](http://purl.obolibrary.org/obo/CL_1000442) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some
-([urothelium](http://purl.obolibrary.org/obo/UBERON_0000365) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [trigone of urinary bladder](http://purl.obolibrary.org/obo/UBERON_0001257)))
-- [urothelial cell of trigone of urinary bladder](http://purl.obolibrary.org/obo/CL_1000442) SubClassOf [bladder urothelial cell](http://purl.obolibrary.org/obo/CL_1001428)
+### vertebral column `http://purl.obolibrary.org/obo/UBERON_0001130`
+#### Removed
+- [vertebral column](http://purl.obolibrary.org/obo/UBERON_0001130) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
+
-### vascular system `http://purl.obolibrary.org/obo/UBERON_0007798`
+### vestibular afferent neuron `http://purl.obolibrary.org/obo/CL_4023112`
#### Removed
-- [vascular system](http://purl.obolibrary.org/obo/UBERON_0007798) [present_in_taxon](http://purl.obolibrary.org/obo/RO_0002175) [Homo sapiens](http://purl.obolibrary.org/obo/NCBITaxon_9606)
+- [vestibular afferent neuron](http://purl.obolibrary.org/obo/CL_4023112) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [vascular system](http://purl.obolibrary.org/obo/UBERON_0007798) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [human_reference_atlas](http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas)
+### vestibulocochlear nerve `http://purl.obolibrary.org/obo/UBERON_0001648`
+#### Removed
+- [vestibulocochlear nerve](http://purl.obolibrary.org/obo/UBERON_0001648) SubClassOf [neuron projection bundle](http://purl.obolibrary.org/obo/CARO_0001001)
+
-### ventral striatum `http://purl.obolibrary.org/obo/UBERON_0005403`
+
+### vimentin `http://purl.obolibrary.org/obo/PR_000017298`
#### Added
-- [ventral striatum](http://purl.obolibrary.org/obo/UBERON_0005403) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "EMAPA:36576"
+- [vimentin](http://purl.obolibrary.org/obo/PR_000017298) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [vimentin (human)](http://purl.obolibrary.org/obo/PR_P08670)
+
-- [ventral striatum](http://purl.obolibrary.org/obo/UBERON_0005403) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "MESH:D066328"
+### vip GABAergic cortical interneuron `http://purl.obolibrary.org/obo/CL_4023016`
-- [ventral striatum](http://purl.obolibrary.org/obo/UBERON_0005403) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "uberon"
+#### Added
+- [vip GABAergic cortical interneuron](http://purl.obolibrary.org/obo/CL_4023016) [symbol](http://purl.obolibrary.org/obo/IAO_0000028) "vip cortical interneuron"
-- [ventral striatum](http://purl.obolibrary.org/obo/UBERON_0005403) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "MA:0002972"
-- [ventral striatum](http://purl.obolibrary.org/obo/UBERON_0005403) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "BAMS:Ventral_striatum"
+### visceral pleura `http://purl.obolibrary.org/obo/UBERON_0002401`
+#### Removed
+- [visceral pleura](http://purl.obolibrary.org/obo/UBERON_0002401) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000)
-- [ventral striatum](http://purl.obolibrary.org/obo/UBERON_0005403) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "BTO:0004702"
-- [ventral striatum](http://purl.obolibrary.org/obo/UBERON_0005403) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "BAMS:STRv"
-- [ventral striatum](http://purl.obolibrary.org/obo/UBERON_0005403) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A composite structure of the telencephalon that is defined in the striatopallidal system by connectivity and neurochemical staining. It includes the nucleus accumbens, the most ventral portions of the caudate nucleus and the putamen, the rostrolateral portion of the anterior perforated substance, the islands of Calleja and a rostral subcommissural portion of substantia innominata. The boundary between the ventral striatum and dorsal striatum is indistinct in sections stained for Nissl substance (Heimer-1995; adapted from Brain Info)."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "NLX:57107"
+### visceral serous pericardium `http://purl.obolibrary.org/obo/UBERON_0002425`
+#### Removed
+- [visceral serous pericardium](http://purl.obolibrary.org/obo/UBERON_0002425) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000)
-- [ventral striatum](http://purl.obolibrary.org/obo/UBERON_0005403) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "FMA:77614"
-- [ventral striatum](http://purl.obolibrary.org/obo/UBERON_0005403) [id](http://www.geneontology.org/formats/oboInOwl#id) "UBERON:0005403"
-- [ventral striatum](http://purl.obolibrary.org/obo/UBERON_0005403) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "striatum ventral region"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ABA:STRv"
+### visceromotor neuron `http://purl.obolibrary.org/obo/CL_0005025`
+#### Removed
+- [visceromotor neuron](http://purl.obolibrary.org/obo/CL_0005025) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [ventral striatum](http://purl.obolibrary.org/obo/UBERON_0005403) [UBPROP_0000001](http://purl.obolibrary.org/obo/UBPROP_0000001) "The term ventral striatum refers to a composite structure of the endbrain that is defined in the striatopallidal system by connectivity and neurochemical staining. It includes the nucleus accumbens, the most ventral portions of the caudate nucleus and the putamen, the rostrolateral portion of the olfactory tubercle, the islands of Calleja and a rostral subcommissural portion of substantia innominata. The boundary between the ventral striatum and dorsal striatum is indistinct in sections stained for Nissl substance ( Heimer-1995 )."
- - [source](http://www.geneontology.org/formats/oboInOwl#source) "neuronames:2341"
-- [ventral striatum](http://purl.obolibrary.org/obo/UBERON_0005403) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "DMBA:15858"
-- [ventral striatum](http://purl.obolibrary.org/obo/UBERON_0005403) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "MBA:493"
+### vomerine dentition `http://purl.obolibrary.org/obo/UBERON_0017615`
+#### Removed
+- [vomerine dentition](http://purl.obolibrary.org/obo/UBERON_0017615) SubClassOf [connected anatomical structure](http://purl.obolibrary.org/obo/CARO_0000003)
-- [ventral striatum](http://purl.obolibrary.org/obo/UBERON_0005403) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "neuronames:2341"
+#### Added
+- [vomerine dentition](http://purl.obolibrary.org/obo/UBERON_0017615) SubClassOf [structure with developmental contribution from neural crest](http://purl.obolibrary.org/obo/UBERON_0010314)
-- [ventral striatum](http://purl.obolibrary.org/obo/UBERON_0005403) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "EFO:0001936"
-- [ventral striatum](http://purl.obolibrary.org/obo/UBERON_0005403) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [efo_slim](http://purl.obolibrary.org/obo/uberon/core#efo_slim)
+### vomeronasal sensory neuron `http://purl.obolibrary.org/obo/CL_1001561`
+#### Removed
+- [vomeronasal sensory neuron](http://purl.obolibrary.org/obo/CL_1001561) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [ventral striatum](http://purl.obolibrary.org/obo/UBERON_0005403) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "striatum ventrale"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "BTO:0004702"
-- [ventral striatum](http://purl.obolibrary.org/obo/UBERON_0005403) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Wikipedia:Ventral_striatum"
-- [ventral striatum](http://purl.obolibrary.org/obo/UBERON_0005403) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "NLX:57107"
+### wall of heart `http://purl.obolibrary.org/obo/UBERON_0037144`
+#### Removed
+- [wall of heart](http://purl.obolibrary.org/obo/UBERON_0037144) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000)
-- [ventral striatum](http://purl.obolibrary.org/obo/UBERON_0005403) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PBA:10091"
-- [ventral striatum](http://purl.obolibrary.org/obo/UBERON_0005403) [label](http://www.w3.org/2000/01/rdf-schema#label) "ventral striatum"
-- [ventral striatum](http://purl.obolibrary.org/obo/UBERON_0005403) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "BAMS:StrV"
+### wall of ureter `http://purl.obolibrary.org/obo/UBERON_0009916`
+#### Removed
+- [wall of ureter](http://purl.obolibrary.org/obo/UBERON_0009916) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [ventral striatum](http://purl.obolibrary.org/obo/UBERON_0005403) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [pheno_slim](http://purl.obolibrary.org/obo/uberon/core#pheno_slim)
-- Class: [ventral striatum](http://purl.obolibrary.org/obo/UBERON_0005403)
-- [ventral striatum](http://purl.obolibrary.org/obo/UBERON_0005403) SubClassOf [contributes to morphology of](http://purl.obolibrary.org/obo/RO_0002433) some [striatum](http://purl.obolibrary.org/obo/UBERON_0002435)
+### white pulp of spleen `http://purl.obolibrary.org/obo/UBERON_0001959`
+#### Removed
+- [white pulp of spleen](http://purl.obolibrary.org/obo/UBERON_0001959) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-- [ventral striatum](http://purl.obolibrary.org/obo/UBERON_0005403) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [striatum](http://purl.obolibrary.org/obo/UBERON_0002435)
- - [source](http://www.geneontology.org/formats/oboInOwl#source) "MA"
-- [ventral striatum](http://purl.obolibrary.org/obo/UBERON_0005403) SubClassOf [gray matter of telencephalon](http://purl.obolibrary.org/obo/UBERON_0011300)
+### xanthophore cell `http://purl.obolibrary.org/obo/CL_0000430`
+#### Removed
+- [xanthophore cell](http://purl.obolibrary.org/obo/CL_0000430) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-### vesicle-mediated transport `http://purl.obolibrary.org/obo/GO_0016192`
-#### Added
-- [vesicle-mediated transport](http://purl.obolibrary.org/obo/GO_0016192) [term tracker item](http://purl.obolibrary.org/obo/IAO_0000233) "https://github.com/geneontology/go-ontology/issues/25421"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI)
-- [vesicle-mediated transport](http://purl.obolibrary.org/obo/GO_0016192) SubClassOf [cellular process](http://purl.obolibrary.org/obo/GO_0009987)
+### yellow bone marrow `http://purl.obolibrary.org/obo/UBERON_0000332`
+#### Removed
+- [yellow bone marrow](http://purl.obolibrary.org/obo/UBERON_0000332) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-### von Economo neuron `http://purl.obolibrary.org/obo/CL_4030039`
-#### Added
-- [von Economo neuron](http://purl.obolibrary.org/obo/CL_4030039) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "An extratelencephalic-projecting glutamatergic cortical neuron that is morphologically-defined with a large, spindle-shaped cell body, thick bipolar dendrites with limited branching and a moderate density of spines, and often an axon initial segment that emanates from the side of the cell body. This cell type is associated with markers POU3F, BMP3 and ITGA4."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "DOI:10.1101/2022.10.12.511898"
+### yolk sac `http://purl.obolibrary.org/obo/UBERON_0001040`
+#### Removed
+- [yolk sac](http://purl.obolibrary.org/obo/UBERON_0001040) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "DOI:10.1007/BF02970950"
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:32127543"
-- [von Economo neuron](http://purl.obolibrary.org/obo/CL_4030039) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "In humans, a von Economo neuron is restricted to layer 5 of the anterior cingulate, frontoinsular, and medial frontopolar regions of cerebral cortex, while in some other species it is also found in the frontal and occipital poles and may not be restricted to layer 5."
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:32127543"
+### yolk sac hematopoietic stem cell `http://purl.obolibrary.org/obo/CL_0002354`
+#### Removed
+- [yolk sac hematopoietic stem cell](http://purl.obolibrary.org/obo/CL_0002354) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006)
-- [von Economo neuron](http://purl.obolibrary.org/obo/CL_4030039) [label](http://www.w3.org/2000/01/rdf-schema#label) "von Economo neuron"
-- [von Economo neuron](http://purl.obolibrary.org/obo/CL_4030039) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "VEN"
- - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation)
- - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:32127543"
+### zeugopod `http://purl.obolibrary.org/obo/UBERON_0002471`
+#### Removed
+- [zeugopod](http://purl.obolibrary.org/obo/UBERON_0002471) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000)
-- [von Economo neuron](http://purl.obolibrary.org/obo/CL_4030039) [date](http://purl.org/dc/terms/date) "2023-05-25T07:29:21Z"^^[dateTime](http://www.w3.org/2001/XMLSchema#dateTime)
-- Class: [von Economo neuron](http://purl.obolibrary.org/obo/CL_4030039)
-- [von Economo neuron](http://purl.obolibrary.org/obo/CL_4030039) SubClassOf [bearer of](http://purl.obolibrary.org/obo/RO_0000053) some [cortical bipolar morphology](http://purl.obolibrary.org/obo/PATO_0070006)
+### zeugopodial skeleton `http://purl.obolibrary.org/obo/UBERON_0011584`
+#### Removed
+- [zeugopodial skeleton](http://purl.obolibrary.org/obo/UBERON_0011584) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000)
-- [von Economo neuron](http://purl.obolibrary.org/obo/CL_4030039) SubClassOf [extratelencephalic-projecting glutamatergic cortical neuron](http://purl.obolibrary.org/obo/CL_4023009)
-### wall of pulmonary artery `http://purl.obolibrary.org/obo/UBERON_0036422`
+### zona glomerulosa of adrenal gland `http://purl.obolibrary.org/obo/UBERON_0002053`
#### Removed
-- [wall of pulmonary artery](http://purl.obolibrary.org/obo/UBERON_0036422) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [human_reference_atlas](http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas)
+- [zona glomerulosa of adrenal gland](http://purl.obolibrary.org/obo/UBERON_0002053) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
-- [wall of pulmonary artery](http://purl.obolibrary.org/obo/UBERON_0036422) [present_in_taxon](http://purl.obolibrary.org/obo/RO_0002175) [Homo sapiens](http://purl.obolibrary.org/obo/NCBITaxon_9606)
+### zone of bone organ `http://purl.obolibrary.org/obo/UBERON_0005913`
+#### Removed
+- [zone of bone organ](http://purl.obolibrary.org/obo/UBERON_0005913) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
-### water channel activity `http://purl.obolibrary.org/obo/GO_0015250`
-#### Added
-- [water channel activity](http://purl.obolibrary.org/obo/GO_0015250) SubClassOf [has participant](http://purl.obolibrary.org/obo/RO_0000057) some [CHEBI_15377](http://purl.obolibrary.org/obo/CHEBI_15377)
+### zone of skin `http://purl.obolibrary.org/obo/UBERON_0000014`
+#### Removed
+- [zone of skin](http://purl.obolibrary.org/obo/UBERON_0000014) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000)
+
diff --git a/src/ontology/reports/cl-edit.owl-obo-report.tsv b/src/ontology/reports/cl-edit.owl-obo-report.tsv
index 87191a849..126bc9f39 100644
--- a/src/ontology/reports/cl-edit.owl-obo-report.tsv
+++ b/src/ontology/reports/cl-edit.owl-obo-report.tsv
@@ -112,13 +112,7 @@ WARN missing_definition CL:0000490 IAO:0000115
WARN missing_definition CL:0000520 IAO:0000115
WARN missing_definition CL:0000521 IAO:0000115
WARN missing_definition CL:0000529 IAO:0000115
-WARN missing_definition CL:0000530 IAO:0000115
-WARN missing_definition CL:0000531 IAO:0000115
WARN missing_definition CL:0000532 IAO:0000115
-WARN missing_definition CL:0000533 IAO:0000115
-WARN missing_definition CL:0000534 IAO:0000115
-WARN missing_definition CL:0000535 IAO:0000115
-WARN missing_definition CL:0000536 IAO:0000115
WARN missing_definition CL:0000544 IAO:0000115
WARN missing_definition CL:0000551 IAO:0000115
WARN missing_definition CL:0000555 IAO:0000115
@@ -326,6 +320,7 @@ WARN missing_definition oboInOwl:shorthand IAO:0000115
WARN missing_obsolete_label CL:0000736 rdfs:label embryonic gland hemocyte
WARN missing_synonymtype_declaration obo:caloha-reqs-vetted#PLURAL rdfs:subPropertyOf
WARN missing_synonymtype_declaration obo:cl#PLURAL rdfs:subPropertyOf
+WARN missing_synonymtype_declaration obo:uberon/core#MISSPELLING rdfs:subPropertyOf
WARN missing_synonymtype_declaration obo:uberon/core#PLURAL rdfs:subPropertyOf
INFO lowercase_definition CL:4023080 IAO:0000115 a L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex that has stellate pyramidal morphology.
INFO lowercase_definition CL:4023081 IAO:0000115 a L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex that has inverted pyramidal morphology.
@@ -524,7 +519,6 @@ INFO missing_superclass CL:0009065 rdfs:subClassOf
INFO missing_superclass CL:0009066 rdfs:subClassOf
INFO missing_superclass CL:0009080 rdfs:subClassOf
INFO missing_superclass CL:0009084 rdfs:subClassOf
-INFO missing_superclass CL:0009086 rdfs:subClassOf
INFO missing_superclass CL:0009089 rdfs:subClassOf
INFO missing_superclass CL:0009092 rdfs:subClassOf
INFO missing_superclass CL:0009093 rdfs:subClassOf
@@ -785,7 +779,6 @@ INFO missing_superclass CL:4033011 rdfs:subClassOf
INFO missing_superclass CL:4033012 rdfs:subClassOf
INFO missing_superclass CL:4033013 rdfs:subClassOf
INFO missing_superclass CL:4033015 rdfs:subClassOf
-INFO missing_superclass CL:4033017 rdfs:subClassOf
INFO missing_superclass CL:4033020 rdfs:subClassOf
INFO missing_superclass CL:4033021 rdfs:subClassOf
INFO missing_superclass CL:4033022 rdfs:subClassOf
diff --git a/src/ontology/subsets/blood_and_immune_upper_slim.json b/src/ontology/subsets/blood_and_immune_upper_slim.json
index bfb01a943..916711a50 100644
--- a/src/ontology/subsets/blood_and_immune_upper_slim.json
+++ b/src/ontology/subsets/blood_and_immune_upper_slim.json
@@ -4,9 +4,9 @@
"meta" : {
"basicPropertyValues" : [ {
"pred" : "http://www.w3.org/2002/07/owl#versionInfo",
- "val" : "2023-06-22"
+ "val" : "2023-07-20"
} ],
- "version" : "http://purl.obolibrary.org/obo/cl/releases/2023-06-22/subsets/blood_and_immune_upper_slim.owl"
+ "version" : "http://purl.obolibrary.org/obo/cl/releases/2023-07-20/subsets/blood_and_immune_upper_slim.owl"
},
"nodes" : [ {
"id" : "http://purl.obolibrary.org/obo/BFO_0000002",
@@ -32,8 +32,9 @@
"type" : "CLASS",
"meta" : {
"definition" : {
- "val" : "A continuant that is a bearer of quality and realizable entity entities, in which other entities inhere and which itself cannot inhere in anything."
- }
+ "val" : "b is an independent continuant = Def. b is a continuant which is such that there is no c and no t such that b s-depends_on c at t. (axiom label in BFO2 Reference: [017-002])"
+ },
+ "comments" : [ "A continuant that is a bearer of quality and realizable entity entities, in which other entities inhere and which itself cannot inhere in anything." ]
}
}, {
"id" : "http://purl.obolibrary.org/obo/BFO_0000015",
@@ -41,8 +42,9 @@
"type" : "CLASS",
"meta" : {
"definition" : {
- "val" : "An occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t."
- }
+ "val" : "p is a process = Def. p is an occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t. (axiom label in BFO2 Reference: [083-003])"
+ },
+ "comments" : [ "An occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t." ]
}
}, {
"id" : "http://purl.obolibrary.org/obo/BFO_0000020",
@@ -50,8 +52,9 @@
"type" : "CLASS",
"meta" : {
"definition" : {
- "val" : "A continuant that inheres in or is borne by other entities. Every instance of A requires some specific instance of B which must always be the same."
- }
+ "val" : "b is a specifically dependent continuant = Def. b is a continuant & there is some independent continuant c which is not a spatial region and which is such that b s-depends_on c at every time t during the course of b’s existence. (axiom label in BFO2 Reference: [050-003])"
+ },
+ "comments" : [ "A continuant that inheres in or is borne by other entities. Every instance of A requires some specific instance of B which must always be the same." ]
}
}, {
"id" : "http://purl.obolibrary.org/obo/BFO_0000040",
@@ -143,6 +146,9 @@
}, {
"pred" : "http://www.w3.org/2000/01/rdf-schema#seeAlso",
"val" : "http://www.obofoundry.org/ro/#OBO_REL:part_of"
+ }, {
+ "pred" : "http://www.w3.org/2000/01/rdf-schema#seeAlso",
+ "val" : "https://wiki.geneontology.org/Part_of"
} ]
}
}, {
@@ -299,6 +305,9 @@
}, {
"pred" : "http://www.w3.org/2000/01/rdf-schema#isDefinedBy",
"val" : "http://purl.obolibrary.org/obo/bfo.owl"
+ }, {
+ "pred" : "http://www.w3.org/2000/01/rdf-schema#seeAlso",
+ "val" : "https://wiki.geneontology.org/Occurs_in"
} ]
}
}, {
@@ -14928,19 +14937,84 @@
"val" : "biological_process"
} ]
}
+ }, {
+ "id" : "http://purl.obolibrary.org/obo/IAO_0000002",
+ "lbl" : "example to be eventually removed",
+ "type" : "INDIVIDUAL",
+ "meta" : {
+ "basicPropertyValues" : [ {
+ "pred" : "http://purl.obolibrary.org/obo/IAO_0000111",
+ "val" : "example to be eventually removed"
+ } ]
+ }
+ }, {
+ "id" : "http://purl.obolibrary.org/obo/IAO_0000103",
+ "lbl" : "failed exploratory term",
+ "type" : "INDIVIDUAL",
+ "meta" : {
+ "definition" : {
+ "val" : "The term was used in an attempt to structure part of the ontology but in retrospect failed to do a good job"
+ },
+ "basicPropertyValues" : [ {
+ "pred" : "http://purl.obolibrary.org/obo/IAO_0000111",
+ "val" : "failed exploratory term"
+ }, {
+ "pred" : "http://purl.obolibrary.org/obo/IAO_0000117",
+ "val" : "Person:Alan Ruttenberg"
+ } ]
+ }
}, {
"id" : "http://purl.obolibrary.org/obo/IAO_0000115",
"lbl" : "definition",
- "type" : "PROPERTY"
+ "type" : "PROPERTY",
+ "meta" : {
+ "definition" : {
+ "val" : "The official definition, explaining the meaning of a class or property. Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions."
+ },
+ "basicPropertyValues" : [ {
+ "pred" : "http://purl.obolibrary.org/obo/IAO_0000111",
+ "val" : "definition"
+ }, {
+ "pred" : "http://purl.obolibrary.org/obo/IAO_0000114",
+ "val" : "http://purl.obolibrary.org/obo/IAO_0000122"
+ }, {
+ "pred" : "http://purl.obolibrary.org/obo/IAO_0000116",
+ "val" : "2012-04-05: \nBarry Smith\n\nThe official OBI definition, explaining the meaning of a class or property: 'Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions' is terrible.\n\nCan you fix to something like:\n\nA statement of necessary and sufficient conditions explaining the meaning of an expression referring to a class or property.\n\nAlan Ruttenberg\n\nYour proposed definition is a reasonable candidate, except that it is very common that necessary and sufficient conditions are not given. Mostly they are necessary, occasionally they are necessary and sufficient or just sufficient. Often they use terms that are not themselves defined and so they effectively can't be evaluated by those criteria. \n\nOn the specifics of the proposed definition:\n\nWe don't have definitions of 'meaning' or 'expression' or 'property'. For 'reference' in the intended sense I think we use the term 'denotation'. For 'expression', I think we you mean symbol, or identifier. For 'meaning' it differs for class and property. For class we want documentation that let's the intended reader determine whether an entity is instance of the class, or not. For property we want documentation that let's the intended reader determine, given a pair of potential relata, whether the assertion that the relation holds is true. The 'intended reader' part suggests that we also specify who, we expect, would be able to understand the definition, and also generalizes over human and computer reader to include textual and logical definition. \n\nPersonally, I am more comfortable weakening definition to documentation, with instructions as to what is desirable. \n\nWe also have the outstanding issue of how to aim different definitions to different audiences. A clinical audience reading chebi wants a different sort of definition documentation/definition from a chemistry trained audience, and similarly there is a need for a definition that is adequate for an ontologist to work with. "
+ }, {
+ "pred" : "http://purl.obolibrary.org/obo/IAO_0000117",
+ "val" : "PERSON:Daniel Schober"
+ }, {
+ "pred" : "http://purl.obolibrary.org/obo/IAO_0000119",
+ "val" : "GROUP:OBI:"
+ }, {
+ "pred" : "http://www.w3.org/2000/01/rdf-schema#isDefinedBy",
+ "val" : "http://purl.obolibrary.org/obo/iao.owl"
+ } ]
+ }
}, {
"id" : "http://purl.obolibrary.org/obo/IAO_0000116",
"lbl" : "editor note",
"type" : "PROPERTY",
"meta" : {
+ "definition" : {
+ "val" : "An administrative note intended for its editor. It may not be included in the publication version of the ontology, so it should contain nothing necessary for end users to understand the ontology."
+ },
"xrefs" : [ {
"val" : "IAO:0000116"
} ],
"basicPropertyValues" : [ {
+ "pred" : "http://purl.obolibrary.org/obo/IAO_0000111",
+ "val" : "editor note"
+ }, {
+ "pred" : "http://purl.obolibrary.org/obo/IAO_0000114",
+ "val" : "http://purl.obolibrary.org/obo/IAO_0000122"
+ }, {
+ "pred" : "http://purl.obolibrary.org/obo/IAO_0000117",
+ "val" : "PERSON:Daniel Schober"
+ }, {
+ "pred" : "http://purl.obolibrary.org/obo/IAO_0000119",
+ "val" : "GROUP:OBI:"
+ }, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
"val" : "uberon"
}, {
@@ -14949,6 +15023,180 @@
}, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#shorthand",
"val" : "editor_note"
+ }, {
+ "pred" : "http://www.w3.org/2000/01/rdf-schema#isDefinedBy",
+ "val" : "http://purl.obolibrary.org/obo/iao.owl"
+ } ]
+ }
+ }, {
+ "id" : "http://purl.obolibrary.org/obo/IAO_0000120",
+ "lbl" : "metadata complete",
+ "type" : "INDIVIDUAL",
+ "meta" : {
+ "definition" : {
+ "val" : "Class has all its metadata, but is either not guaranteed to be in its final location in the asserted IS_A hierarchy or refers to another class that is not complete."
+ },
+ "basicPropertyValues" : [ {
+ "pred" : "http://purl.obolibrary.org/obo/IAO_0000111",
+ "val" : "metadata complete"
+ } ]
+ }
+ }, {
+ "id" : "http://purl.obolibrary.org/obo/IAO_0000121",
+ "lbl" : "organizational term",
+ "type" : "INDIVIDUAL",
+ "meta" : {
+ "definition" : {
+ "val" : "Term created to ease viewing/sort terms for development purpose, and will not be included in a release"
+ },
+ "basicPropertyValues" : [ {
+ "pred" : "http://purl.obolibrary.org/obo/IAO_0000111",
+ "val" : "organizational term"
+ } ]
+ }
+ }, {
+ "id" : "http://purl.obolibrary.org/obo/IAO_0000122",
+ "lbl" : "ready for release",
+ "type" : "INDIVIDUAL",
+ "meta" : {
+ "definition" : {
+ "val" : "Class has undergone final review, is ready for use, and will be included in the next release. Any class lacking \"ready_for_release\" should be considered likely to change place in hierarchy, have its definition refined, or be obsoleted in the next release. Those classes deemed \"ready_for_release\" will also derived from a chain of ancestor classes that are also \"ready_for_release.\""
+ },
+ "basicPropertyValues" : [ {
+ "pred" : "http://purl.obolibrary.org/obo/IAO_0000111",
+ "val" : "ready for release"
+ } ]
+ }
+ }, {
+ "id" : "http://purl.obolibrary.org/obo/IAO_0000123",
+ "lbl" : "metadata incomplete",
+ "type" : "INDIVIDUAL",
+ "meta" : {
+ "definition" : {
+ "val" : "Class is being worked on; however, the metadata (including definition) are not complete or sufficiently clear to the branch editors."
+ },
+ "basicPropertyValues" : [ {
+ "pred" : "http://purl.obolibrary.org/obo/IAO_0000111",
+ "val" : "metadata incomplete"
+ } ]
+ }
+ }, {
+ "id" : "http://purl.obolibrary.org/obo/IAO_0000124",
+ "lbl" : "uncurated",
+ "type" : "INDIVIDUAL",
+ "meta" : {
+ "definition" : {
+ "val" : "Nothing done yet beyond assigning a unique class ID and proposing a preferred term."
+ },
+ "basicPropertyValues" : [ {
+ "pred" : "http://purl.obolibrary.org/obo/IAO_0000111",
+ "val" : "uncurated"
+ } ]
+ }
+ }, {
+ "id" : "http://purl.obolibrary.org/obo/IAO_0000125",
+ "lbl" : "pending final vetting",
+ "type" : "INDIVIDUAL",
+ "meta" : {
+ "definition" : {
+ "val" : "All definitions, placement in the asserted IS_A hierarchy and required minimal metadata are complete. The class is awaiting a final review by someone other than the term editor."
+ },
+ "basicPropertyValues" : [ {
+ "pred" : "http://purl.obolibrary.org/obo/IAO_0000111",
+ "val" : "pending final vetting"
+ } ]
+ }
+ }, {
+ "id" : "http://purl.obolibrary.org/obo/IAO_0000136",
+ "lbl" : "is about",
+ "type" : "PROPERTY",
+ "meta" : {
+ "definition" : {
+ "val" : "A (currently) primitive relation that relates an information artifact to an entity."
+ },
+ "basicPropertyValues" : [ {
+ "pred" : "http://purl.obolibrary.org/obo/IAO_0000112",
+ "val" : "This document is about information artifacts and their representations"
+ }, {
+ "pred" : "http://purl.obolibrary.org/obo/IAO_0000114",
+ "val" : "http://purl.obolibrary.org/obo/IAO_0000125"
+ }, {
+ "pred" : "http://purl.obolibrary.org/obo/IAO_0000116",
+ "val" : "7/6/2009 Alan Ruttenberg. Following discussion with Jonathan Rees, and introduction of \"mentions\" relation. Weaken the is_about relationship to be primitive. \n\nWe will try to build it back up by elaborating the various subproperties that are more precisely defined.\n\nSome currently missing phenomena that should be considered \"about\" are predications - \"The only person who knows the answer is sitting beside me\" , Allegory, Satire, and other literary forms that can be topical without explicitly mentioning the topic."
+ }, {
+ "pred" : "http://purl.obolibrary.org/obo/IAO_0000117",
+ "val" : "person:Alan Ruttenberg"
+ }, {
+ "pred" : "http://purl.obolibrary.org/obo/IAO_0000119",
+ "val" : "Smith, Ceusters, Ruttenberg, 2000 years of philosophy"
+ } ]
+ }
+ }, {
+ "id" : "http://purl.obolibrary.org/obo/IAO_0000226",
+ "lbl" : "placeholder removed",
+ "type" : "INDIVIDUAL",
+ "meta" : {
+ "basicPropertyValues" : [ {
+ "pred" : "http://purl.obolibrary.org/obo/IAO_0000111",
+ "val" : "placeholder removed"
+ } ]
+ }
+ }, {
+ "id" : "http://purl.obolibrary.org/obo/IAO_0000227",
+ "lbl" : "terms merged",
+ "type" : "INDIVIDUAL",
+ "meta" : {
+ "basicPropertyValues" : [ {
+ "pred" : "http://purl.obolibrary.org/obo/IAO_0000111",
+ "val" : "terms merged"
+ }, {
+ "pred" : "http://purl.obolibrary.org/obo/IAO_0000116",
+ "val" : "An editor note should explain what were the merged terms and the reason for the merge."
+ } ]
+ }
+ }, {
+ "id" : "http://purl.obolibrary.org/obo/IAO_0000228",
+ "lbl" : "term imported",
+ "type" : "INDIVIDUAL",
+ "meta" : {
+ "basicPropertyValues" : [ {
+ "pred" : "http://purl.obolibrary.org/obo/IAO_0000111",
+ "val" : "term imported"
+ }, {
+ "pred" : "http://purl.obolibrary.org/obo/IAO_0000116",
+ "val" : "This is to be used when the original term has been replaced by a term imported from an other ontology. An editor note should indicate what is the URI of the new term to use."
+ } ]
+ }
+ }, {
+ "id" : "http://purl.obolibrary.org/obo/IAO_0000229",
+ "lbl" : "term split",
+ "type" : "INDIVIDUAL",
+ "meta" : {
+ "basicPropertyValues" : [ {
+ "pred" : "http://purl.obolibrary.org/obo/IAO_0000111",
+ "val" : "term split"
+ }, {
+ "pred" : "http://purl.obolibrary.org/obo/IAO_0000116",
+ "val" : "This is to be used when a term has been split in two or more new terms. An editor note should indicate the reason for the split and indicate the URIs of the new terms created."
+ } ]
+ }
+ }, {
+ "id" : "http://purl.obolibrary.org/obo/IAO_0000231",
+ "lbl" : "has obsolescence reason",
+ "type" : "PROPERTY",
+ "meta" : {
+ "definition" : {
+ "val" : "Relates an annotation property to an obsolescence reason. The values of obsolescence reasons come from a list of predefined terms, instances of the class obsolescence reason specification."
+ },
+ "basicPropertyValues" : [ {
+ "pred" : "http://purl.obolibrary.org/obo/IAO_0000111",
+ "val" : "has obsolescence reason"
+ }, {
+ "pred" : "http://purl.obolibrary.org/obo/IAO_0000117",
+ "val" : "PERSON:Alan Ruttenberg"
+ }, {
+ "pred" : "http://purl.obolibrary.org/obo/IAO_0000117",
+ "val" : "PERSON:Melanie Courtot"
} ]
}
}, {
@@ -14956,10 +15204,29 @@
"lbl" : "term tracker item",
"type" : "PROPERTY",
"meta" : {
+ "definition" : {
+ "val" : "An IRI or similar locator for a request or discussion of an ontology term."
+ },
+ "comments" : [ "The 'tracker item' can associate a tracker with a specific ontology term." ],
"xrefs" : [ {
"val" : "IAO:0000233"
} ],
"basicPropertyValues" : [ {
+ "pred" : "http://purl.obolibrary.org/obo/IAO_0000111",
+ "val" : "term tracker item"
+ }, {
+ "pred" : "http://purl.obolibrary.org/obo/IAO_0000112",
+ "val" : "the URI for an OBI Terms ticket at sourceforge, such as https://sourceforge.net/p/obi/obi-terms/772/"
+ }, {
+ "pred" : "http://purl.obolibrary.org/obo/IAO_0000114",
+ "val" : "http://purl.obolibrary.org/obo/IAO_0000125"
+ }, {
+ "pred" : "http://purl.obolibrary.org/obo/IAO_0000117",
+ "val" : "Person: Jie Zheng, Chris Stoeckert, Alan Ruttenberg"
+ }, {
+ "pred" : "http://purl.obolibrary.org/obo/IAO_0000119",
+ "val" : "Person: Jie Zheng, Chris Stoeckert, Alan Ruttenberg"
+ }, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
"val" : "external"
}, {
@@ -14976,19 +15243,138 @@
"val" : "term_tracker_item"
} ]
}
+ }, {
+ "id" : "http://purl.obolibrary.org/obo/IAO_0000410",
+ "lbl" : "universal",
+ "type" : "INDIVIDUAL",
+ "meta" : {
+ "basicPropertyValues" : [ {
+ "pred" : "http://purl.obolibrary.org/obo/IAO_0000111",
+ "val" : "universal"
+ }, {
+ "pred" : "http://purl.obolibrary.org/obo/IAO_0000116",
+ "val" : "Hard to give a definition for. Intuitively a \"natural kind\" rather than a collection of any old things, which a class is able to be, formally. At the meta level, universals are defined as positives, are disjoint with their siblings, have single asserted parents."
+ }, {
+ "pred" : "http://purl.obolibrary.org/obo/IAO_0000117",
+ "val" : "Alan Ruttenberg"
+ }, {
+ "pred" : "http://purl.obolibrary.org/obo/IAO_0000119",
+ "val" : "A Formal Theory of Substances, Qualities, and Universals, http://ontology.buffalo.edu/bfo/SQU.pdf"
+ } ]
+ }
+ }, {
+ "id" : "http://purl.obolibrary.org/obo/IAO_0000420",
+ "lbl" : "defined class",
+ "type" : "INDIVIDUAL",
+ "meta" : {
+ "definition" : {
+ "val" : "A defined class is a class that is defined by a set of logically necessary and sufficient conditions but is not a universal"
+ },
+ "basicPropertyValues" : [ {
+ "pred" : "http://purl.obolibrary.org/obo/IAO_0000111",
+ "val" : "defined class"
+ }, {
+ "pred" : "http://purl.obolibrary.org/obo/IAO_0000116",
+ "val" : "\"definitions\", in some readings, always are given by necessary and sufficient conditions. So one must be careful (and this is difficult sometimes) to distinguish between defined classes and universal."
+ }, {
+ "pred" : "http://purl.obolibrary.org/obo/IAO_0000117",
+ "val" : "Alan Ruttenberg"
+ } ]
+ }
+ }, {
+ "id" : "http://purl.obolibrary.org/obo/IAO_0000421",
+ "lbl" : "named class expression",
+ "type" : "INDIVIDUAL",
+ "meta" : {
+ "definition" : {
+ "val" : "A named class expression is a logical expression that is given a name. The name can be used in place of the expression."
+ },
+ "basicPropertyValues" : [ {
+ "pred" : "http://purl.obolibrary.org/obo/IAO_0000111",
+ "val" : "named class expression"
+ }, {
+ "pred" : "http://purl.obolibrary.org/obo/IAO_0000116",
+ "val" : "named class expressions are used in order to have more concise logical definition but their extensions may not be interesting classes on their own. In languages such as OWL, with no provisions for macros, these show up as actuall classes. Tools may with to not show them as such, and to replace uses of the macros with their expansions"
+ }, {
+ "pred" : "http://purl.obolibrary.org/obo/IAO_0000117",
+ "val" : "Alan Ruttenberg"
+ } ]
+ }
+ }, {
+ "id" : "http://purl.obolibrary.org/obo/IAO_0000423",
+ "lbl" : "to be replaced with external ontology term",
+ "type" : "INDIVIDUAL",
+ "meta" : {
+ "definition" : {
+ "val" : "Terms with this status should eventually replaced with a term from another ontology."
+ },
+ "basicPropertyValues" : [ {
+ "pred" : "http://purl.obolibrary.org/obo/IAO_0000111",
+ "val" : "to be replaced with external ontology term"
+ }, {
+ "pred" : "http://purl.obolibrary.org/obo/IAO_0000117",
+ "val" : "Alan Ruttenberg"
+ }, {
+ "pred" : "http://purl.obolibrary.org/obo/IAO_0000119",
+ "val" : "group:OBI"
+ } ]
+ }
}, {
"id" : "http://purl.obolibrary.org/obo/IAO_0000424",
"lbl" : "expand expression to",
- "type" : "PROPERTY"
+ "type" : "PROPERTY",
+ "meta" : {
+ "definition" : {
+ "val" : "A macro expansion tag applied to an object property (or possibly a data property) which can be used by a macro-expansion engine to generate more complex expressions from simpler ones"
+ },
+ "basicPropertyValues" : [ {
+ "pred" : "http://purl.obolibrary.org/obo/IAO_0000111",
+ "val" : "expand expression to"
+ }, {
+ "pred" : "http://purl.obolibrary.org/obo/IAO_0000112",
+ "val" : "ObjectProperty: RO_0002104\nLabel: has plasma membrane part\nAnnotations: IAO_0000424 \"http://purl.obolibrary.org/obo/BFO_0000051 some (http://purl.org/obo/owl/GO#GO_0005886 and http://purl.obolibrary.org/obo/BFO_0000051 some ?Y)\"\n"
+ }, {
+ "pred" : "http://purl.obolibrary.org/obo/IAO_0000117",
+ "val" : "Chris Mungall"
+ } ]
+ }
+ }, {
+ "id" : "http://purl.obolibrary.org/obo/IAO_0000428",
+ "lbl" : "requires discussion",
+ "type" : "INDIVIDUAL",
+ "meta" : {
+ "definition" : {
+ "val" : "A term that is metadata complete, has been reviewed, and problems have been identified that require discussion before release. Such a term requires editor note(s) to identify the outstanding issues."
+ },
+ "basicPropertyValues" : [ {
+ "pred" : "http://purl.obolibrary.org/obo/IAO_0000111",
+ "val" : "requires discussion"
+ }, {
+ "pred" : "http://purl.obolibrary.org/obo/IAO_0000117",
+ "val" : "Alan Ruttenberg"
+ }, {
+ "pred" : "http://purl.obolibrary.org/obo/IAO_0000119",
+ "val" : "group:OBI"
+ } ]
+ }
}, {
"id" : "http://purl.obolibrary.org/obo/IAO_0000700",
"lbl" : "preferred_root",
"type" : "PROPERTY",
"meta" : {
+ "definition" : {
+ "val" : "Ontology annotation property. Relates an ontology to a term that is a designated root term of the ontology. Display tools like OLS can use terms annotated with this property as the starting point for rendering the ontology class hierarchy. There can be more than one root."
+ },
"xrefs" : [ {
"val" : "IAO:0000700"
} ],
"basicPropertyValues" : [ {
+ "pred" : "http://purl.obolibrary.org/obo/IAO_0000111",
+ "val" : "has ontology root term"
+ }, {
+ "pred" : "http://purl.obolibrary.org/obo/IAO_0000117",
+ "val" : "Nicolas Matentzoglu"
+ }, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
"val" : "uberon"
}, {
@@ -15002,7 +15388,26 @@
}, {
"id" : "http://purl.obolibrary.org/obo/IAO_0100001",
"lbl" : "term replaced by",
- "type" : "PROPERTY"
+ "type" : "PROPERTY",
+ "meta" : {
+ "definition" : {
+ "val" : "Use on obsolete terms, relating the term to another term that can be used as a substitute"
+ },
+ "comments" : [ "Add as annotation triples in the granting ontology" ],
+ "basicPropertyValues" : [ {
+ "pred" : "http://purl.obolibrary.org/obo/IAO_0000111",
+ "val" : "term replaced by"
+ }, {
+ "pred" : "http://purl.obolibrary.org/obo/IAO_0000114",
+ "val" : "http://purl.obolibrary.org/obo/IAO_0000125"
+ }, {
+ "pred" : "http://purl.obolibrary.org/obo/IAO_0000117",
+ "val" : "Person:Alan Ruttenberg"
+ }, {
+ "pred" : "http://purl.obolibrary.org/obo/IAO_0000119",
+ "val" : "Person:Alan Ruttenberg"
+ } ]
+ }
}, {
"id" : "http://purl.obolibrary.org/obo/NCBITaxon_1",
"lbl" : "root",
@@ -17157,6 +17562,9 @@
"basicPropertyValues" : [ {
"pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
"val" : "protein"
+ }, {
+ "pred" : "https://w3id.org/semapv/vocab/crossSpeciesExactMatch",
+ "val" : "http://purl.obolibrary.org/obo/PR_P08575"
} ]
}
}, {
@@ -17207,6 +17615,9 @@
"basicPropertyValues" : [ {
"pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
"val" : "protein"
+ }, {
+ "pred" : "https://w3id.org/semapv/vocab/crossSpeciesExactMatch",
+ "val" : "http://purl.obolibrary.org/obo/PR_P11215"
} ]
}
}, {
@@ -17250,6 +17661,9 @@
"basicPropertyValues" : [ {
"pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
"val" : "protein"
+ }, {
+ "pred" : "https://w3id.org/semapv/vocab/crossSpeciesExactMatch",
+ "val" : "http://purl.obolibrary.org/obo/PR_P20702"
} ]
}
}, {
@@ -17379,6 +17793,9 @@
"basicPropertyValues" : [ {
"pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
"val" : "protein"
+ }, {
+ "pred" : "https://w3id.org/semapv/vocab/crossSpeciesExactMatch",
+ "val" : "http://purl.obolibrary.org/obo/PR_P13591"
} ]
}
}, {
@@ -17478,6 +17895,9 @@
"basicPropertyValues" : [ {
"pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
"val" : "protein"
+ }, {
+ "pred" : "https://w3id.org/semapv/vocab/crossSpeciesExactMatch",
+ "val" : "http://purl.obolibrary.org/obo/PR_P01732"
} ]
}
}, {
@@ -17616,6 +18036,9 @@
"basicPropertyValues" : [ {
"pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
"val" : "protein"
+ }, {
+ "pred" : "https://w3id.org/semapv/vocab/crossSpeciesExactMatch",
+ "val" : "http://purl.obolibrary.org/obo/PR_P32246"
} ]
}
}, {
@@ -17675,6 +18098,9 @@
"basicPropertyValues" : [ {
"pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
"val" : "protein"
+ }, {
+ "pred" : "https://w3id.org/semapv/vocab/crossSpeciesExactMatch",
+ "val" : "http://purl.obolibrary.org/obo/PR_P51677"
} ]
}
}, {
@@ -17892,6 +18318,9 @@
"basicPropertyValues" : [ {
"pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
"val" : "protein"
+ }, {
+ "pred" : "https://w3id.org/semapv/vocab/crossSpeciesExactMatch",
+ "val" : "http://purl.obolibrary.org/obo/PR_P31997"
} ]
}
}, {
@@ -17990,6 +18419,9 @@
"basicPropertyValues" : [ {
"pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
"val" : "protein"
+ }, {
+ "pred" : "https://w3id.org/semapv/vocab/crossSpeciesExactMatch",
+ "val" : "http://purl.obolibrary.org/obo/PR_O14638"
} ]
}
}, {
@@ -18080,6 +18512,9 @@
"basicPropertyValues" : [ {
"pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
"val" : "protein"
+ }, {
+ "pred" : "https://w3id.org/semapv/vocab/crossSpeciesExactMatch",
+ "val" : "http://purl.obolibrary.org/obo/PR_P28907"
} ]
}
}, {
@@ -18113,6 +18548,9 @@
"basicPropertyValues" : [ {
"pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
"val" : "protein"
+ }, {
+ "pred" : "https://w3id.org/semapv/vocab/crossSpeciesExactMatch",
+ "val" : "http://purl.obolibrary.org/obo/PR_P33151"
} ]
}
}, {
@@ -18240,6 +18678,9 @@
"basicPropertyValues" : [ {
"pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
"val" : "protein"
+ }, {
+ "pred" : "https://w3id.org/semapv/vocab/crossSpeciesExactMatch",
+ "val" : "http://purl.obolibrary.org/obo/PR_P06127"
} ]
}
}, {
@@ -18281,6 +18722,9 @@
"basicPropertyValues" : [ {
"pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
"val" : "protein"
+ }, {
+ "pred" : "https://w3id.org/semapv/vocab/crossSpeciesExactMatch",
+ "val" : "http://purl.obolibrary.org/obo/PR_P43235"
} ]
}
}, {
@@ -18397,6 +18841,9 @@
"basicPropertyValues" : [ {
"pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
"val" : "protein"
+ }, {
+ "pred" : "https://w3id.org/semapv/vocab/crossSpeciesExactMatch",
+ "val" : "http://purl.obolibrary.org/obo/PR_Q01344"
} ]
}
}, {
@@ -18441,6 +18888,9 @@
"basicPropertyValues" : [ {
"pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
"val" : "protein"
+ }, {
+ "pred" : "https://w3id.org/semapv/vocab/crossSpeciesExactMatch",
+ "val" : "http://purl.obolibrary.org/obo/PR_P16871"
} ]
}
}, {
@@ -18508,6 +18958,9 @@
"basicPropertyValues" : [ {
"pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
"val" : "protein"
+ }, {
+ "pred" : "https://w3id.org/semapv/vocab/crossSpeciesExactMatch",
+ "val" : "http://purl.obolibrary.org/obo/PR_P16150"
} ]
}
}, {
@@ -18598,6 +19051,9 @@
"basicPropertyValues" : [ {
"pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
"val" : "protein"
+ }, {
+ "pred" : "https://w3id.org/semapv/vocab/crossSpeciesExactMatch",
+ "val" : "http://purl.obolibrary.org/obo/PR_P08473"
} ]
}
}, {
@@ -18629,6 +19085,9 @@
"basicPropertyValues" : [ {
"pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
"val" : "protein"
+ }, {
+ "pred" : "https://w3id.org/semapv/vocab/crossSpeciesExactMatch",
+ "val" : "http://purl.obolibrary.org/obo/PR_Q02548"
} ]
}
}, {
@@ -18678,6 +19137,9 @@
"basicPropertyValues" : [ {
"pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
"val" : "protein"
+ }, {
+ "pred" : "https://w3id.org/semapv/vocab/crossSpeciesExactMatch",
+ "val" : "http://purl.obolibrary.org/obo/PR_P25063"
} ]
}
}, {
@@ -18716,6 +19178,9 @@
"basicPropertyValues" : [ {
"pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
"val" : "protein"
+ }, {
+ "pred" : "https://w3id.org/semapv/vocab/crossSpeciesExactMatch",
+ "val" : "http://purl.obolibrary.org/obo/PR_P18827"
} ]
}
}, {
@@ -18760,6 +19225,9 @@
"basicPropertyValues" : [ {
"pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
"val" : "protein"
+ }, {
+ "pred" : "https://w3id.org/semapv/vocab/crossSpeciesExactMatch",
+ "val" : "http://purl.obolibrary.org/obo/PR_P13686"
} ]
}
}, {
@@ -18795,6 +19263,9 @@
"basicPropertyValues" : [ {
"pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
"val" : "protein"
+ }, {
+ "pred" : "https://w3id.org/semapv/vocab/crossSpeciesExactMatch",
+ "val" : "http://purl.obolibrary.org/obo/PR_P17947"
} ]
}
}, {
@@ -18839,6 +19310,9 @@
"basicPropertyValues" : [ {
"pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
"val" : "protein"
+ }, {
+ "pred" : "https://w3id.org/semapv/vocab/crossSpeciesExactMatch",
+ "val" : "http://purl.obolibrary.org/obo/PR_P02786"
} ]
}
}, {
@@ -18930,6 +19404,9 @@
"basicPropertyValues" : [ {
"pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
"val" : "protein"
+ }, {
+ "pred" : "https://w3id.org/semapv/vocab/crossSpeciesExactMatch",
+ "val" : "http://purl.obolibrary.org/obo/PR_Q9Y6Q6"
} ]
}
}, {
@@ -19016,6 +19493,9 @@
"basicPropertyValues" : [ {
"pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
"val" : "protein"
+ }, {
+ "pred" : "https://w3id.org/semapv/vocab/crossSpeciesExactMatch",
+ "val" : "http://purl.obolibrary.org/obo/PR_Q03405"
} ]
}
}, {
@@ -19086,6 +19566,9 @@
"basicPropertyValues" : [ {
"pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
"val" : "protein"
+ }, {
+ "pred" : "https://w3id.org/semapv/vocab/crossSpeciesExactMatch",
+ "val" : "http://purl.obolibrary.org/obo/PR_P07333"
} ]
}
}, {
@@ -19182,6 +19665,9 @@
"basicPropertyValues" : [ {
"pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
"val" : "protein"
+ }, {
+ "pred" : "https://w3id.org/semapv/vocab/crossSpeciesExactMatch",
+ "val" : "http://purl.obolibrary.org/obo/PR_P35968"
} ]
}
}, {
@@ -19353,6 +19839,9 @@
"basicPropertyValues" : [ {
"pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
"val" : "protein"
+ }, {
+ "pred" : "https://w3id.org/semapv/vocab/crossSpeciesExactMatch",
+ "val" : "http://purl.obolibrary.org/obo/PR_P15918"
} ]
}
}, {
@@ -19377,6 +19866,9 @@
"basicPropertyValues" : [ {
"pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
"val" : "protein"
+ }, {
+ "pred" : "https://w3id.org/semapv/vocab/crossSpeciesExactMatch",
+ "val" : "http://purl.obolibrary.org/obo/PR_P55895"
} ]
}
}, {
@@ -19466,6 +19958,9 @@
"basicPropertyValues" : [ {
"pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
"val" : "protein"
+ }, {
+ "pred" : "https://w3id.org/semapv/vocab/crossSpeciesExactMatch",
+ "val" : "http://purl.obolibrary.org/obo/PR_P49715"
} ]
}
}, {
@@ -19536,6 +20031,9 @@
"basicPropertyValues" : [ {
"pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
"val" : "protein"
+ }, {
+ "pred" : "https://w3id.org/semapv/vocab/crossSpeciesExactMatch",
+ "val" : "http://purl.obolibrary.org/obo/PR_P04053"
} ]
}
}, {
@@ -19573,6 +20071,9 @@
"basicPropertyValues" : [ {
"pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
"val" : "protein"
+ }, {
+ "pred" : "https://w3id.org/semapv/vocab/crossSpeciesExactMatch",
+ "val" : "http://purl.obolibrary.org/obo/PR_P12319"
} ]
}
}, {
@@ -19610,6 +20111,9 @@
"basicPropertyValues" : [ {
"pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
"val" : "protein"
+ }, {
+ "pred" : "https://w3id.org/semapv/vocab/crossSpeciesExactMatch",
+ "val" : "http://purl.obolibrary.org/obo/PR_P01100"
} ]
}
}, {
@@ -19654,6 +20158,9 @@
"basicPropertyValues" : [ {
"pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
"val" : "protein"
+ }, {
+ "pred" : "https://w3id.org/semapv/vocab/crossSpeciesExactMatch",
+ "val" : "http://purl.obolibrary.org/obo/PR_P15976"
} ]
}
}, {
@@ -19678,6 +20185,9 @@
"basicPropertyValues" : [ {
"pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
"val" : "protein"
+ }, {
+ "pred" : "https://w3id.org/semapv/vocab/crossSpeciesExactMatch",
+ "val" : "http://purl.obolibrary.org/obo/PR_P23769"
} ]
}
}, {
@@ -19711,6 +20221,9 @@
"basicPropertyValues" : [ {
"pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
"val" : "protein"
+ }, {
+ "pred" : "https://w3id.org/semapv/vocab/crossSpeciesExactMatch",
+ "val" : "http://purl.obolibrary.org/obo/PR_P26010"
} ]
}
}, {
@@ -19754,6 +20267,9 @@
"basicPropertyValues" : [ {
"pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
"val" : "protein"
+ }, {
+ "pred" : "https://w3id.org/semapv/vocab/crossSpeciesExactMatch",
+ "val" : "http://purl.obolibrary.org/obo/PR_Q00653"
} ]
}
}, {
@@ -19788,6 +20304,9 @@
"basicPropertyValues" : [ {
"pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
"val" : "protein"
+ }, {
+ "pred" : "https://w3id.org/semapv/vocab/crossSpeciesExactMatch",
+ "val" : "http://purl.obolibrary.org/obo/PR_Q15465"
} ]
}
}, {
@@ -19836,6 +20355,9 @@
"basicPropertyValues" : [ {
"pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
"val" : "protein"
+ }, {
+ "pred" : "https://w3id.org/semapv/vocab/crossSpeciesExactMatch",
+ "val" : "http://purl.obolibrary.org/obo/PR_P17542"
} ]
}
}, {
@@ -19877,6 +20399,9 @@
"basicPropertyValues" : [ {
"pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
"val" : "protein"
+ }, {
+ "pred" : "https://w3id.org/semapv/vocab/crossSpeciesExactMatch",
+ "val" : "http://purl.obolibrary.org/obo/PR_Q13445"
} ]
}
}, {
@@ -20503,6 +21028,9 @@
}, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#shorthand",
"val" : "located_in"
+ }, {
+ "pred" : "http://www.w3.org/2000/01/rdf-schema#seeAlso",
+ "val" : "https://wiki.geneontology.org/Located_in"
} ]
}
}, {
@@ -20657,7 +21185,7 @@
} ],
"basicPropertyValues" : [ {
"pred" : "http://www.geneontology.org/formats/oboInOwl#created_by",
- "val" : "dos"
+ "val" : "https://orcid.org/0000-0002-7073-9172"
}, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
"val" : "2017-05-24T09:30:46Z"
@@ -20683,7 +21211,7 @@
} ],
"basicPropertyValues" : [ {
"pred" : "http://www.geneontology.org/formats/oboInOwl#created_by",
- "val" : "dos"
+ "val" : "https://orcid.org/0000-0002-7073-9172"
}, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
"val" : "2017-05-24T09:31:01Z"
@@ -20706,7 +21234,7 @@
"comments" : [ "By convention GO molecular functions are classified by their effector function and internal regulatory functions are treated as components. So, for example calmodulin has a protein binding activity that has positive regulatory component activity calcium binding activity. Receptor tyrosine kinase activity is a tyrosine kinase activity that has positive regulatory component 'ligand binding'." ],
"basicPropertyValues" : [ {
"pred" : "http://www.geneontology.org/formats/oboInOwl#created_by",
- "val" : "dos"
+ "val" : "https://orcid.org/0000-0002-7073-9172"
}, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
"val" : "2017-05-24T09:31:17Z"
@@ -20720,7 +21248,7 @@
"comments" : [ "A 'has component activity' B if A is A and B are molecular functions (GO_0003674) and A has_component B." ],
"basicPropertyValues" : [ {
"pred" : "http://www.geneontology.org/formats/oboInOwl#created_by",
- "val" : "dos"
+ "val" : "https://orcid.org/0000-0002-7073-9172"
}, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
"val" : "2017-05-24T09:44:33Z"
@@ -20736,7 +21264,7 @@
},
"basicPropertyValues" : [ {
"pred" : "http://www.geneontology.org/formats/oboInOwl#created_by",
- "val" : "dos"
+ "val" : "https://orcid.org/0000-0002-7073-9172"
}, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
"val" : "2017-05-24T09:49:21Z"
@@ -20752,7 +21280,7 @@
},
"basicPropertyValues" : [ {
"pred" : "http://www.geneontology.org/formats/oboInOwl#created_by",
- "val" : "dos"
+ "val" : "https://orcid.org/0000-0002-7073-9172"
}, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
"val" : "2017-07-20T17:19:37Z"
@@ -20766,7 +21294,7 @@
"comments" : [ "Process(P2) is directly regulated by process(P1) iff: P1 regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding regulates the kinase activity (P2) of protein B then P1 directly regulates P2." ],
"basicPropertyValues" : [ {
"pred" : "http://www.geneontology.org/formats/oboInOwl#created_by",
- "val" : "dos"
+ "val" : "https://orcid.org/0000-0002-7073-9172"
}, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
"val" : "2017-09-17T13:52:24Z"
@@ -20779,11 +21307,11 @@
"meta" : {
"definition" : {
"val" : "Process(P2) is directly negatively regulated by process(P1) iff: P1 negatively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding negatively regulates the kinase activity (P2) of protein B then P2 directly negatively regulated by P1.",
- "xrefs" : [ "GOC:dos" ]
+ "xrefs" : [ "https://orcid.org/0000-0002-7073-9172" ]
},
"basicPropertyValues" : [ {
"pred" : "http://www.geneontology.org/formats/oboInOwl#created_by",
- "val" : "dos"
+ "val" : "https://orcid.org/0000-0002-7073-9172"
}, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
"val" : "2017-09-17T13:52:38Z"
@@ -20796,11 +21324,11 @@
"meta" : {
"definition" : {
"val" : "Process(P2) is directly postively regulated by process(P1) iff: P1 positively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding positively regulates the kinase activity (P2) of protein B then P2 is directly postively regulated by P1.",
- "xrefs" : [ "GOC:dos" ]
+ "xrefs" : [ "https://orcid.org/0000-0002-7073-9172" ]
},
"basicPropertyValues" : [ {
"pred" : "http://www.geneontology.org/formats/oboInOwl#created_by",
- "val" : "dos"
+ "val" : "https://orcid.org/0000-0002-7073-9172"
}, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
"val" : "2017-09-17T13:52:47Z"
@@ -20813,12 +21341,12 @@
"meta" : {
"definition" : {
"val" : "A 'has effector activity' B if A and B are GO molecular functions (GO_0003674), A 'has component activity' B and B is the effector (output function) of B. Each compound function has only one effector activity.",
- "xrefs" : [ "GOC:dos" ]
+ "xrefs" : [ "https://orcid.org/0000-0002-7073-9172" ]
},
"comments" : [ "This relation is designed for constructing compound molecular functions, typically in combination with one or more regulatory component activity relations." ],
"basicPropertyValues" : [ {
"pred" : "http://www.geneontology.org/formats/oboInOwl#created_by",
- "val" : "dos"
+ "val" : "https://orcid.org/0000-0002-7073-9172"
}, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
"val" : "2017-09-22T14:14:36Z"
@@ -20844,6 +21372,9 @@
"lbl" : "simultaneous with",
"type" : "PROPERTY",
"meta" : {
+ "definition" : {
+ "val" : "x simultaneous with y iff ω(x) = ω(y) and ω(α ) = ω(α), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point and '=' indicates the same instance in time."
+ },
"comments" : [ "t1 simultaneous_with t2 iff:= t1 before_or_simultaneous_with t2 and not (t1 before t2)" ],
"subsets" : [ "http://purl.obolibrary.org/obo/ro/subsets#ro-eco" ],
"xrefs" : [ {
@@ -20940,7 +21471,8 @@
"type" : "PROPERTY",
"meta" : {
"definition" : {
- "val" : "Relation between a neuron and an anatomical structure that its soma is part of."
+ "val" : "Relation between a neuron and an anatomical structure that its soma is part of.",
+ "xrefs" : [ "https://orcid.org/0000-0002-7073-9172" ]
},
"xrefs" : [ {
"val" : "RO:0002100"
@@ -22531,6 +23063,9 @@
}, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#shorthand",
"val" : "has_input"
+ }, {
+ "pred" : "http://www.w3.org/2000/01/rdf-schema#seeAlso",
+ "val" : "https://wiki.geneontology.org/Has_input"
} ]
}
}, {
@@ -22560,6 +23095,9 @@
}, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#shorthand",
"val" : "has_output"
+ }, {
+ "pred" : "http://www.w3.org/2000/01/rdf-schema#seeAlso",
+ "val" : "https://wiki.geneontology.org/Has_output"
} ]
}
}, {
@@ -22727,7 +23265,7 @@
"val" : "A gene product that has some activity, where that activity may be a part of a pathway or upstream of the pathway."
}, {
"pred" : "http://www.w3.org/2000/01/rdf-schema#seeAlso",
- "val" : "http://wiki.geneontology.org/index.php/Acts_upstream_of_or_within"
+ "val" : "https://wiki.geneontology.org/Acts_upstream_of_or_within"
} ]
}
}, {
@@ -22799,7 +23337,7 @@
"type" : "PROPERTY",
"meta" : {
"definition" : {
- "val" : "Inverse of 'expressed in'"
+ "val" : "y expresses x if and only if there is a gene expression process (GO:0010467) that occurs in y, and one of the following holds: (i) x is a gene, and x is transcribed into a transcript as part of the gene expression process (ii) x is a transcript, and x was transcribed from a gene as part of the gene expression process (iii) x is a mature gene product (protein or RNA), and x was translated or otherwise processed from a transcript that was transcribed as part of the gene expression process."
},
"basicPropertyValues" : [ {
"pred" : "http://purl.obolibrary.org/obo/IAO_0000114",
@@ -22999,6 +23537,9 @@
}, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#shorthand",
"val" : "causally_upstream_of,_positive_effect"
+ }, {
+ "pred" : "http://www.w3.org/2000/01/rdf-schema#seeAlso",
+ "val" : "https://wiki.geneontology.org/Causally_upstream_of,_positive_effect"
} ]
}
}, {
@@ -23025,6 +23566,9 @@
}, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#shorthand",
"val" : "causally_upstream_of,_negative_effect"
+ }, {
+ "pred" : "http://www.w3.org/2000/01/rdf-schema#seeAlso",
+ "val" : "https://wiki.geneontology.org/Causally_upstream_of,_negative_effect"
} ]
}
}, {
@@ -23168,6 +23712,9 @@
}, {
"pred" : "http://purl.obolibrary.org/obo/IAO_0000232",
"val" : "This relation differs from the parent relation 'capable of' in that the parent is weaker and only expresses a capability that may not be actually realized, whereas this relation is always realized."
+ }, {
+ "pred" : "http://www.w3.org/2000/01/rdf-schema#seeAlso",
+ "val" : "https://wiki.geneontology.org/Enables"
} ]
}
}, {
@@ -23246,7 +23793,7 @@
"val" : "enables part of"
}, {
"pred" : "http://www.w3.org/2000/01/rdf-schema#seeAlso",
- "val" : "http://wiki.geneontology.org/index.php/Involved_in"
+ "val" : "https://wiki.geneontology.org/Involved_in"
} ]
}
}, {
@@ -23292,6 +23839,9 @@
"basicPropertyValues" : [ {
"pred" : "http://purl.obolibrary.org/obo/IAO_0000117",
"val" : "https://orcid.org/0000-0002-6601-2165"
+ }, {
+ "pred" : "http://www.w3.org/2000/01/rdf-schema#seeAlso",
+ "val" : "https://wiki.geneontology.org/Enabled_by"
} ]
}
}, {
@@ -24021,6 +24571,9 @@
}, {
"pred" : "http://purl.obolibrary.org/obo/RO_0002579",
"val" : "http://purl.obolibrary.org/obo/RO_0002213"
+ }, {
+ "pred" : "http://www.w3.org/2000/01/rdf-schema#seeAlso",
+ "val" : "https://wiki.geneontology.org/Indirectly_positively_regulates"
} ]
}
}, {
@@ -24040,6 +24593,9 @@
}, {
"pred" : "http://purl.obolibrary.org/obo/RO_0002579",
"val" : "http://purl.obolibrary.org/obo/RO_0002212"
+ }, {
+ "pred" : "http://www.w3.org/2000/01/rdf-schema#seeAlso",
+ "val" : "https://wiki.geneontology.org/Indirectly_negatively_regulates"
} ]
}
}, {
@@ -24239,7 +24795,7 @@
"meta" : {
"definition" : {
"val" : "c executes activity in d if and only if c enables p and p occurs_in d. Assuming no action at a distance by gene products, if a gene product enables (is capable of) a process that occurs in some structure, it must have at least some part in that structure.",
- "xrefs" : [ "GOC:cjm", "GOC:dos" ]
+ "xrefs" : [ "https://orcid.org/0000-0002-6601-2165", "https://orcid.org/0000-0002-7073-9172" ]
},
"comments" : [ "" ],
"synonyms" : [ {
@@ -24255,6 +24811,9 @@
}, {
"pred" : "http://purl.obolibrary.org/obo/IAO_0000118",
"val" : "executes activity in"
+ }, {
+ "pred" : "http://www.w3.org/2000/01/rdf-schema#seeAlso",
+ "val" : "https://wiki.geneontology.org/Is_active_in"
} ]
}
}, {
@@ -25049,7 +25608,7 @@
"val" : "https://orcid.org/0000-0002-6601-2165"
}, {
"pred" : "http://purl.obolibrary.org/obo/IAO_0000119",
- "val" : "GOC:cjm"
+ "val" : "https://orcid.org/0000-0002-6601-2165"
}, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
"val" : "uberon"
@@ -25317,6 +25876,19 @@
"val" : "process_has_causal_agent"
} ]
}
+ }, {
+ "id" : "http://purl.obolibrary.org/obo/RO_0002610",
+ "lbl" : "correlated with",
+ "type" : "PROPERTY",
+ "meta" : {
+ "definition" : {
+ "val" : "A relationship that holds between two entities, where the entities exhibit a statistical dependence relationship. The entities may be statistical variables, or they may be other kinds of entities such as diseases, chemical entities or processes."
+ },
+ "basicPropertyValues" : [ {
+ "pred" : "http://purl.obolibrary.org/obo/IAO_0000232",
+ "val" : "Groups both positive and negative correlation"
+ } ]
+ }
}, {
"id" : "http://purl.obolibrary.org/obo/RO_0002629",
"lbl" : "directly positively regulates",
@@ -25344,6 +25916,9 @@
}, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#shorthand",
"val" : "directly_positively_regulates"
+ }, {
+ "pred" : "http://www.w3.org/2000/01/rdf-schema#seeAlso",
+ "val" : "https://wiki.geneontology.org/Directly_positively_regulates"
} ]
}
}, {
@@ -25373,6 +25948,9 @@
}, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#shorthand",
"val" : "directly_negatively_regulates"
+ }, {
+ "pred" : "http://www.w3.org/2000/01/rdf-schema#seeAlso",
+ "val" : "https://wiki.geneontology.org/Directly_negatively_regulates"
} ]
}
}, {
@@ -25467,7 +26045,7 @@
"meta" : {
"definition" : {
"val" : "p has primary output c if (a) p has output c and (b) the goal of process is to modify, produce, or transform c.",
- "xrefs" : [ "GOC:cjm", "GOC:dph", "GOC:kva", "GOC:pt" ]
+ "xrefs" : [ "https://orcid.org/0000-0002-6601-2165", "GOC:dph", "GOC:kva", "GOC:pt" ]
},
"subsets" : [ "http://purl.obolibrary.org/obo/valid_for_go_ontology" ],
"xrefs" : [ {
@@ -25494,7 +26072,7 @@
"meta" : {
"definition" : {
"val" : "p has primary input c if (a) p has input c and (b) the goal of process is to modify, consume, or transform c.",
- "xrefs" : [ "GOC:cjm", "GOC:dph", "GOC:kva", "GOC:pt" ]
+ "xrefs" : [ "https://orcid.org/0000-0002-6601-2165", "GOC:dph", "GOC:kva", "GOC:pt" ]
},
"subsets" : [ "http://purl.obolibrary.org/obo/valid_for_go_ontology" ],
"xrefs" : [ {
@@ -25547,7 +26125,7 @@
"val" : "2018-01-26T23:49:30Z"
}, {
"pred" : "http://www.w3.org/2000/01/rdf-schema#seeAlso",
- "val" : "http://wiki.geneontology.org/index.php/Acts_upstream_of_or_within,_positive_effect"
+ "val" : "https://wiki.geneontology.org/Acts_upstream_of_or_within,_positive_effect"
} ]
}
}, {
@@ -25565,6 +26143,9 @@
}, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
"val" : "2018-01-26T23:49:51Z"
+ }, {
+ "pred" : "http://www.w3.org/2000/01/rdf-schema#seeAlso",
+ "val" : "https://wiki.geneontology.org/Acts_upstream_of_or_within,_negative_effect"
} ]
}
}, {
@@ -25587,7 +26168,7 @@
"val" : "2018-01-26T23:53:14Z"
}, {
"pred" : "http://www.w3.org/2000/01/rdf-schema#seeAlso",
- "val" : "http://wiki.geneontology.org/index.php/Acts_upstream_of,_positive_effect"
+ "val" : "https://wiki.geneontology.org/Acts_upstream_of,_positive_effect"
} ]
}
}, {
@@ -25610,7 +26191,7 @@
"val" : "2018-01-26T23:53:22Z"
}, {
"pred" : "http://www.w3.org/2000/01/rdf-schema#seeAlso",
- "val" : "http://wiki.geneontology.org/index.php/Acts_upstream_of,_negative_effect"
+ "val" : "https://wiki.geneontology.org/Acts_upstream_of,_negative_effect"
} ]
}
}, {
@@ -25627,6 +26208,9 @@
}, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
"val" : "2018-03-13T23:55:05Z"
+ }, {
+ "pred" : "http://www.w3.org/2000/01/rdf-schema#seeAlso",
+ "val" : "https://wiki.geneontology.org/Causally_upstream_of_or_within,_negative_effect"
} ]
}
}, {
@@ -25643,6 +26227,9 @@
}, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
"val" : "2018-03-13T23:55:19Z"
+ }, {
+ "pred" : "http://www.w3.org/2000/01/rdf-schema#seeAlso",
+ "val" : "https://wiki.geneontology.org/Causally_upstream_of_or_within,_positive_effect"
} ]
}
}, {
@@ -25685,7 +26272,7 @@
} ],
"basicPropertyValues" : [ {
"pred" : "http://www.geneontology.org/formats/oboInOwl#created_by",
- "val" : "pg"
+ "val" : "https://orcid.org/0000-0003-1813-6857"
}, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
"val" : "2020-06-08T17:21:33Z"
@@ -25708,7 +26295,7 @@
} ],
"basicPropertyValues" : [ {
"pred" : "http://www.geneontology.org/formats/oboInOwl#created_by",
- "val" : "pg"
+ "val" : "https://orcid.org/0000-0003-1813-6857"
}, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
"val" : "2021-02-26T07:28:29Z"
@@ -25730,7 +26317,7 @@
},
"basicPropertyValues" : [ {
"pred" : "http://www.geneontology.org/formats/oboInOwl#created_by",
- "val" : "pg"
+ "val" : "https://orcid.org/0000-0003-1813-6857"
}, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
"val" : "2022-09-26T06:07:17Z"
@@ -25746,7 +26333,7 @@
},
"basicPropertyValues" : [ {
"pred" : "http://www.geneontology.org/formats/oboInOwl#created_by",
- "val" : "pg"
+ "val" : "https://orcid.org/0000-0003-1813-6857"
}, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
"val" : "2022-09-26T06:08:01Z"
@@ -25766,7 +26353,7 @@
} ],
"basicPropertyValues" : [ {
"pred" : "http://www.geneontology.org/formats/oboInOwl#created_by",
- "val" : "http://orcid.org/0000-0002-1373-1705"
+ "val" : "https://orcid.org/0000-0002-1373-1705"
}, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
"val" : "2020-07-17T09:26:52Z"
@@ -25792,7 +26379,7 @@
} ],
"basicPropertyValues" : [ {
"pred" : "http://www.geneontology.org/formats/oboInOwl#created_by",
- "val" : "http://orcid.org/0000-0002-1373-1705"
+ "val" : "https://orcid.org/0000-0002-1373-1705"
}, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
"val" : "2020-07-20T12:10:09Z"
@@ -25859,10 +26446,10 @@
"val" : "'Ly-76 high positive erythrocyte' equivalent to 'enucleate erythrocyte' and (has_high_plasma_membrane_amount some 'lymphocyte antigen 76 (mouse)')"
}, {
"pred" : "http://purl.org/dc/terms/contributor",
- "val" : "http://orcid.org/0000-0003-1617-8244"
+ "val" : "https://orcid.org/0000-0003-1617-8244"
}, {
"pred" : "http://purl.org/dc/terms/contributor",
- "val" : "http://orcid.org/0000-0003-1940-6740"
+ "val" : "https://orcid.org/0000-0003-1940-6740"
} ]
}
}, {
@@ -25879,10 +26466,10 @@
"val" : "'DN2b thymocyte' equivalent to 'DN2 thymocyte' and (has_low_plasma_membrane_amount some 'mast/stem cell growth factor receptor')"
}, {
"pred" : "http://purl.org/dc/terms/contributor",
- "val" : "http://orcid.org/0000-0003-1617-8244"
+ "val" : "https://orcid.org/0000-0003-1617-8244"
}, {
"pred" : "http://purl.org/dc/terms/contributor",
- "val" : "http://orcid.org/0000-0003-1940-6740"
+ "val" : "https://orcid.org/0000-0003-1940-6740"
} ]
}
}, {
@@ -25917,6 +26504,22 @@
"val" : "2021-11-08T12:00:00Z"
} ]
}
+ }, {
+ "id" : "http://purl.obolibrary.org/obo/RO_0017003",
+ "lbl" : "positively correlated with",
+ "type" : "PROPERTY",
+ "meta" : {
+ "definition" : {
+ "val" : "A relation between entities in which one increases or decreases as the other does the same."
+ },
+ "basicPropertyValues" : [ {
+ "pred" : "http://purl.obolibrary.org/obo/IAO_0000118",
+ "val" : "directly correlated with"
+ }, {
+ "pred" : "http://purl.org/dc/terms/contributor",
+ "val" : "https://orcid.org/0000-0003-1909-9269"
+ } ]
+ }
}, {
"id" : "http://purl.obolibrary.org/obo/RO_0019000",
"lbl" : "regulates characteristic",
@@ -26977,8 +27580,17 @@
"val" : "XAO:1000006"
} ],
"basicPropertyValues" : [ {
+ "pred" : "http://purl.obolibrary.org/obo/RO_0002174",
+ "val" : "http://purl.obolibrary.org/obo/NCBITaxon_7955"
+ }, {
+ "pred" : "http://purl.obolibrary.org/obo/UBPROP_0000008",
+ "val" : "In zebrafish, the times of neurulation and segmentation overlap so extensively there is no distinct neurula period of development, such as occurs largely before segmentation in amphibian embryos."
+ }, {
"pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
"val" : "uberon"
+ }, {
+ "pred" : "http://www.w3.org/2000/01/rdf-schema#seeAlso",
+ "val" : "https://github.com/obophenotype/developmental-stage-ontologies/issues/84"
}, {
"pred" : "http://www.w3.org/2000/01/rdf-schema#seeAlso",
"val" : "https://github.com/obophenotype/uberon/issues/343"
@@ -27015,6 +27627,9 @@
"basicPropertyValues" : [ {
"pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
"val" : "uberon"
+ }, {
+ "pred" : "http://www.w3.org/2000/01/rdf-schema#seeAlso",
+ "val" : "https://github.com/obophenotype/developmental-stage-ontologies/issues/84"
}, {
"pred" : "http://www.w3.org/2000/01/rdf-schema#seeAlso",
"val" : "https://github.com/obophenotype/uberon/issues/533"
@@ -36185,6 +36800,10 @@
"id" : "http://purl.obolibrary.org/obo/uberon#PLURAL",
"lbl" : "plural term",
"type" : "PROPERTY"
+ }, {
+ "id" : "http://purl.obolibrary.org/obo/uberon/core#MISSPELLING",
+ "lbl" : "a mis-spelling that is in common use and thus recorded",
+ "type" : "PROPERTY"
}, {
"id" : "http://purl.obolibrary.org/obo/uberon/core#PLURAL",
"lbl" : "plural term",
@@ -36844,10 +37463,6 @@
"sub" : "http://purl.obolibrary.org/obo/CL_0000038",
"pred" : "http://purl.obolibrary.org/obo/RO_0002202",
"obj" : "http://purl.obolibrary.org/obo/CL_0000050"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CL_0000040",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000006"
}, {
"sub" : "http://purl.obolibrary.org/obo/CL_0000040",
"pred" : "is_a",
@@ -36964,10 +37579,6 @@
"sub" : "http://purl.obolibrary.org/obo/CL_0000056",
"pred" : "is_a",
"obj" : "http://purl.obolibrary.org/obo/CL_0000680"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CL_0000057",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000000"
}, {
"sub" : "http://purl.obolibrary.org/obo/CL_0000057",
"pred" : "is_a",
@@ -37050,10 +37661,6 @@
"sub" : "http://purl.obolibrary.org/obo/CL_0000084",
"pred" : "http://purl.obolibrary.org/obo/RO_0002215",
"obj" : "http://purl.obolibrary.org/obo/GO_0002456"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CL_0000092",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000006"
}, {
"sub" : "http://purl.obolibrary.org/obo/CL_0000092",
"pred" : "is_a",
@@ -37114,10 +37721,6 @@
"sub" : "http://purl.obolibrary.org/obo/CL_0000092",
"pred" : "http://purl.obolibrary.org/obo/RO_0002215",
"obj" : "http://purl.obolibrary.org/obo/GO_0045453"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CL_0000094",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000006"
}, {
"sub" : "http://purl.obolibrary.org/obo/CL_0000094",
"pred" : "is_a",
@@ -37168,10 +37771,6 @@
"sub" : "http://purl.obolibrary.org/obo/CL_0000094",
"pred" : "http://purl.obolibrary.org/obo/RO_0002104",
"obj" : "http://purl.obolibrary.org/obo/PR_000001969"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CL_0000097",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000006"
}, {
"sub" : "http://purl.obolibrary.org/obo/CL_0000097",
"pred" : "is_a",
@@ -37288,10 +37887,6 @@
"sub" : "http://purl.obolibrary.org/obo/CL_0000183",
"pred" : "is_a",
"obj" : "http://purl.obolibrary.org/obo/CL_0000003"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CL_0000187",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000000"
}, {
"sub" : "http://purl.obolibrary.org/obo/CL_0000187",
"pred" : "is_a",
@@ -37664,10 +38259,6 @@
"sub" : "http://purl.obolibrary.org/obo/CL_0000542",
"pred" : "http://purl.obolibrary.org/obo/RO_0002202",
"obj" : "http://purl.obolibrary.org/obo/CL_0000051"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CL_0000547",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000006"
}, {
"sub" : "http://purl.obolibrary.org/obo/CL_0000547",
"pred" : "is_a",
@@ -37758,10 +38349,6 @@
"sub" : "http://purl.obolibrary.org/obo/CL_0000548",
"pred" : "http://purl.obolibrary.org/obo/RO_0002160",
"obj" : "http://purl.obolibrary.org/obo/NCBITaxon_33208"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CL_0000549",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000006"
}, {
"sub" : "http://purl.obolibrary.org/obo/CL_0000549",
"pred" : "is_a",
@@ -37788,10 +38375,6 @@
"sub" : "http://purl.obolibrary.org/obo/CL_0000549",
"pred" : "http://purl.obolibrary.org/obo/RO_0002104",
"obj" : "http://purl.obolibrary.org/obo/PR_000001945"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CL_0000550",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000006"
}, {
"sub" : "http://purl.obolibrary.org/obo/CL_0000550",
"pred" : "is_a",
@@ -37936,10 +38519,6 @@
"sub" : "http://purl.obolibrary.org/obo/CL_0000556",
"pred" : "http://purl.obolibrary.org/obo/RO_0002202",
"obj" : "http://purl.obolibrary.org/obo/CL_0000553"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CL_0000557",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000006"
}, {
"sub" : "http://purl.obolibrary.org/obo/CL_0000557",
"pred" : "is_a",
@@ -37988,10 +38567,6 @@
"sub" : "http://purl.obolibrary.org/obo/CL_0000557",
"pred" : "http://purl.obolibrary.org/obo/RO_0002215",
"obj" : "http://purl.obolibrary.org/obo/GO_0030851"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CL_0000558",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000006"
}, {
"sub" : "http://purl.obolibrary.org/obo/CL_0000558",
"pred" : "is_a",
@@ -38062,10 +38637,6 @@
"sub" : "http://purl.obolibrary.org/obo/CL_0000558",
"pred" : "http://purl.obolibrary.org/obo/RO_0002215",
"obj" : "http://purl.obolibrary.org/obo/GO_0071971"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CL_0000559",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000006"
}, {
"sub" : "http://purl.obolibrary.org/obo/CL_0000559",
"pred" : "is_a",
@@ -38096,10 +38667,6 @@
"sub" : "http://purl.obolibrary.org/obo/CL_0000559",
"pred" : "http://purl.obolibrary.org/obo/RO_0002202",
"obj" : "http://purl.obolibrary.org/obo/CL_0000040"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CL_0000566",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000006"
}, {
"sub" : "http://purl.obolibrary.org/obo/CL_0000566",
"pred" : "is_a",
@@ -38194,10 +38761,6 @@
"sub" : "http://purl.obolibrary.org/obo/CL_0000647",
"pred" : "http://purl.obolibrary.org/obo/RO_0002202",
"obj" : "http://purl.obolibrary.org/obo/CL_0000235"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CL_0000680",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000000"
}, {
"sub" : "http://purl.obolibrary.org/obo/CL_0000680",
"pred" : "is_a",
@@ -38232,10 +38795,6 @@
"sub" : "http://purl.obolibrary.org/obo/CL_0000723",
"pred" : "http://purl.obolibrary.org/obo/RO_0002215",
"obj" : "http://purl.obolibrary.org/obo/GO_0048103"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CL_0000738",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000000"
}, {
"sub" : "http://purl.obolibrary.org/obo/CL_0000738",
"pred" : "is_a",
@@ -38292,10 +38851,6 @@
"sub" : "http://purl.obolibrary.org/obo/CL_0000762",
"pred" : "http://purl.obolibrary.org/obo/RO_0002215",
"obj" : "http://purl.obolibrary.org/obo/GO_0007596"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CL_0000763",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000000"
}, {
"sub" : "http://purl.obolibrary.org/obo/CL_0000763",
"pred" : "is_a",
@@ -38542,10 +39097,6 @@
"sub" : "http://purl.obolibrary.org/obo/CL_0000785",
"pred" : "http://purl.obolibrary.org/obo/RO_0002353",
"obj" : "http://purl.obolibrary.org/obo/GO_0002335"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CL_0000786",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000006"
}, {
"sub" : "http://purl.obolibrary.org/obo/CL_0000786",
"pred" : "is_a",
@@ -38584,10 +39135,6 @@
"sub" : "http://purl.obolibrary.org/obo/CL_0000786",
"pred" : "http://purl.obolibrary.org/obo/RO_0002202",
"obj" : "http://purl.obolibrary.org/obo/CL_0000980"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CL_0000789",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000006"
}, {
"sub" : "http://purl.obolibrary.org/obo/CL_0000789",
"pred" : "is_a",
@@ -38602,10 +39149,6 @@
"sub" : "http://purl.obolibrary.org/obo/CL_0000789",
"pred" : "http://purl.obolibrary.org/obo/RO_0002104",
"obj" : "http://purl.obolibrary.org/obo/GO_0042105"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CL_0000798",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000006"
}, {
"sub" : "http://purl.obolibrary.org/obo/CL_0000798",
"pred" : "is_a",
@@ -38770,10 +39313,6 @@
"sub" : "http://purl.obolibrary.org/obo/CL_0000828",
"pred" : "http://purl.obolibrary.org/obo/RO_0002215",
"obj" : "http://purl.obolibrary.org/obo/GO_0002574"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CL_0000831",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000006"
}, {
"sub" : "http://purl.obolibrary.org/obo/CL_0000831",
"pred" : "is_a",
@@ -38892,10 +39431,6 @@
"sub" : "http://purl.obolibrary.org/obo/CL_0000831",
"pred" : "http://purl.obolibrary.org/obo/RO_0015016",
"obj" : "http://purl.obolibrary.org/obo/PR_000007431"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CL_0000837",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000006"
}, {
"sub" : "http://purl.obolibrary.org/obo/CL_0000837",
"pred" : "is_a",
@@ -39018,10 +39553,6 @@
"val" : "true"
} ]
}
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CL_0000889",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000006"
}, {
"sub" : "http://purl.obolibrary.org/obo/CL_0000889",
"pred" : "is_a",
@@ -39170,10 +39701,6 @@
"sub" : "http://purl.obolibrary.org/obo/CL_0000988",
"pred" : "is_a",
"obj" : "http://purl.obolibrary.org/obo/CL_0002371"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CL_0000990",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000006"
}, {
"sub" : "http://purl.obolibrary.org/obo/CL_0000990",
"pred" : "is_a",
@@ -39278,10 +39805,6 @@
"sub" : "http://purl.obolibrary.org/obo/CL_0001065",
"pred" : "http://purl.obolibrary.org/obo/RO_0002215",
"obj" : "http://purl.obolibrary.org/obo/GO_0045087"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CL_0001200",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000006"
}, {
"sub" : "http://purl.obolibrary.org/obo/CL_0001200",
"pred" : "is_a",
@@ -39336,10 +39859,6 @@
"sub" : "http://purl.obolibrary.org/obo/CL_0002009",
"pred" : "http://purl.obolibrary.org/obo/RO_0002215",
"obj" : "http://purl.obolibrary.org/obo/GO_0043011"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CL_0002028",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000006"
}, {
"sub" : "http://purl.obolibrary.org/obo/CL_0002028",
"pred" : "is_a",
@@ -39388,10 +39907,6 @@
"sub" : "http://purl.obolibrary.org/obo/CL_0002028",
"pred" : "http://purl.obolibrary.org/obo/RO_0002215",
"obj" : "http://purl.obolibrary.org/obo/GO_0060374"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CL_0002031",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000000"
}, {
"sub" : "http://purl.obolibrary.org/obo/CL_0002031",
"pred" : "is_a",
@@ -39404,10 +39919,6 @@
"sub" : "http://purl.obolibrary.org/obo/CL_0002031",
"pred" : "http://purl.obolibrary.org/obo/RO_0002202",
"obj" : "http://purl.obolibrary.org/obo/CL_0002032"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CL_0002032",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000000"
}, {
"sub" : "http://purl.obolibrary.org/obo/CL_0002032",
"pred" : "is_a",
@@ -39420,10 +39931,6 @@
"sub" : "http://purl.obolibrary.org/obo/CL_0002032",
"pred" : "http://purl.obolibrary.org/obo/RO_0002202",
"obj" : "http://purl.obolibrary.org/obo/CL_0000837"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CL_0002077",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000000"
}, {
"sub" : "http://purl.obolibrary.org/obo/CL_0002077",
"pred" : "is_a",
@@ -39436,10 +39943,6 @@
"sub" : "http://purl.obolibrary.org/obo/CL_0002077",
"pred" : "http://purl.obolibrary.org/obo/RO_0002202",
"obj" : "http://purl.obolibrary.org/obo/CL_0000221"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CL_0002078",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000000"
}, {
"sub" : "http://purl.obolibrary.org/obo/CL_0002078",
"pred" : "is_a",
@@ -39594,10 +40097,6 @@
"sub" : "http://purl.obolibrary.org/obo/CL_0002546",
"pred" : "is_a",
"obj" : "http://purl.obolibrary.org/obo/CL_0002371"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CL_0002679",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000006"
}, {
"sub" : "http://purl.obolibrary.org/obo/CL_0002679",
"pred" : "is_a",
@@ -39652,10 +40151,6 @@
"sub" : "http://purl.obolibrary.org/obo/CL_0007001",
"pred" : "is_a",
"obj" : "http://purl.obolibrary.org/obo/CL_0000003"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CL_0007004",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000000"
}, {
"sub" : "http://purl.obolibrary.org/obo/CL_0007004",
"pred" : "is_a",
@@ -39700,10 +40195,6 @@
"sub" : "http://purl.obolibrary.org/obo/CL_0011012",
"pred" : "is_a",
"obj" : "http://purl.obolibrary.org/obo/CL_0002321"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/CL_0011026",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000000"
}, {
"sub" : "http://purl.obolibrary.org/obo/CL_0011026",
"pred" : "is_a",
@@ -44390,10 +44881,6 @@
"sub" : "http://purl.obolibrary.org/obo/UBERON_0000111",
"pred" : "http://purl.obolibrary.org/obo/BFO_0000050",
"obj" : "http://purl.obolibrary.org/obo/UBERON_0000068"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/UBERON_0000111",
- "pred" : "http://purl.obolibrary.org/obo/BFO_0000062",
- "obj" : "http://purl.obolibrary.org/obo/UBERON_0000110"
}, {
"sub" : "http://purl.obolibrary.org/obo/UBERON_0000111",
"pred" : "http://purl.obolibrary.org/obo/RO_0002082",
@@ -44422,10 +44909,6 @@
"sub" : "http://purl.obolibrary.org/obo/UBERON_0000154",
"pred" : "http://purl.obolibrary.org/obo/RO_0002160",
"obj" : "http://purl.obolibrary.org/obo/NCBITaxon_33213"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/UBERON_0000165",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000000"
}, {
"sub" : "http://purl.obolibrary.org/obo/UBERON_0000165",
"pred" : "is_a",
@@ -44462,10 +44945,6 @@
"sub" : "http://purl.obolibrary.org/obo/UBERON_0000165",
"pred" : "http://purl.obolibrary.org/obo/RO_0002202",
"obj" : "http://purl.obolibrary.org/obo/UBERON_0035804"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/UBERON_0000178",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000000"
}, {
"sub" : "http://purl.obolibrary.org/obo/UBERON_0000178",
"pred" : "is_a",
@@ -44524,10 +45003,6 @@
"sub" : "http://purl.obolibrary.org/obo/UBERON_0000179",
"pred" : "http://purl.obolibrary.org/obo/RO_0002160",
"obj" : "http://purl.obolibrary.org/obo/NCBITaxon_6072"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/UBERON_0000307",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000000"
}, {
"sub" : "http://purl.obolibrary.org/obo/UBERON_0000307",
"pred" : "is_a",
@@ -44540,10 +45015,6 @@
"sub" : "http://purl.obolibrary.org/obo/UBERON_0000307",
"pred" : "http://purl.obolibrary.org/obo/RO_0002491",
"obj" : "http://purl.obolibrary.org/obo/UBERON_0000108"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/UBERON_0000383",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000006"
}, {
"sub" : "http://purl.obolibrary.org/obo/UBERON_0000383",
"pred" : "is_a",
@@ -44708,10 +45179,6 @@
"sub" : "http://purl.obolibrary.org/obo/UBERON_0000490",
"pred" : "is_a",
"obj" : "http://purl.obolibrary.org/obo/UBERON_0000483"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/UBERON_0000915",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0010000"
}, {
"sub" : "http://purl.obolibrary.org/obo/UBERON_0000915",
"pred" : "is_a",
@@ -44928,10 +45395,6 @@
"sub" : "http://purl.obolibrary.org/obo/UBERON_0001009",
"pred" : "http://purl.obolibrary.org/obo/RO_0002492",
"obj" : "http://purl.obolibrary.org/obo/UBERON_0000066"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/UBERON_0001015",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000006"
}, {
"sub" : "http://purl.obolibrary.org/obo/UBERON_0001015",
"pred" : "is_a",
@@ -44944,10 +45407,6 @@
"sub" : "http://purl.obolibrary.org/obo/UBERON_0001015",
"pred" : "http://purl.obolibrary.org/obo/RO_0002473",
"obj" : "http://purl.obolibrary.org/obo/UBERON_0001630"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/UBERON_0001016",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000006"
}, {
"sub" : "http://purl.obolibrary.org/obo/UBERON_0001016",
"pred" : "is_a",
@@ -45095,10 +45554,6 @@
"val" : "VSAO-modified"
} ]
}
- }, {
- "sub" : "http://purl.obolibrary.org/obo/UBERON_0001555",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000000"
}, {
"sub" : "http://purl.obolibrary.org/obo/UBERON_0001555",
"pred" : "is_a",
@@ -45161,10 +45616,6 @@
"sub" : "http://purl.obolibrary.org/obo/UBERON_0001969",
"pred" : "http://purl.obolibrary.org/obo/RO_0002221",
"obj" : "http://purl.obolibrary.org/obo/CL_0000232"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/UBERON_0001981",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000000"
}, {
"sub" : "http://purl.obolibrary.org/obo/UBERON_0001981",
"pred" : "is_a",
@@ -45286,10 +45737,6 @@
"sub" : "http://purl.obolibrary.org/obo/UBERON_0002075",
"pred" : "http://purl.obolibrary.org/obo/RO_0001025",
"obj" : "http://purl.obolibrary.org/obo/UBERON_0002323"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/UBERON_0002090",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000000"
}, {
"sub" : "http://purl.obolibrary.org/obo/UBERON_0002090",
"pred" : "is_a",
@@ -45328,10 +45775,6 @@
"sub" : "http://purl.obolibrary.org/obo/UBERON_0002193",
"pred" : "http://purl.obolibrary.org/obo/RO_0002160",
"obj" : "http://purl.obolibrary.org/obo/NCBITaxon_33213"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/UBERON_0002204",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000006"
}, {
"sub" : "http://purl.obolibrary.org/obo/UBERON_0002204",
"pred" : "is_a",
@@ -45374,10 +45817,6 @@
"sub" : "http://purl.obolibrary.org/obo/UBERON_0002224",
"pred" : "http://purl.obolibrary.org/obo/RO_0002572",
"obj" : "http://purl.obolibrary.org/obo/UBERON_0000915"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/UBERON_0002323",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000000"
}, {
"sub" : "http://purl.obolibrary.org/obo/UBERON_0002323",
"pred" : "is_a",
@@ -45470,10 +45909,6 @@
"sub" : "http://purl.obolibrary.org/obo/UBERON_0002328",
"pred" : "http://purl.obolibrary.org/obo/RO_0003000",
"obj" : "http://purl.obolibrary.org/obo/PR_000014841"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/UBERON_0002329",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000000"
}, {
"sub" : "http://purl.obolibrary.org/obo/UBERON_0002329",
"pred" : "is_a",
@@ -45659,10 +46094,6 @@
"sub" : "http://purl.obolibrary.org/obo/UBERON_0002385",
"pred" : "http://purl.obolibrary.org/obo/RO_0002473",
"obj" : "http://purl.obolibrary.org/obo/CL_0000187"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/UBERON_0002390",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000006"
}, {
"sub" : "http://purl.obolibrary.org/obo/UBERON_0002390",
"pred" : "is_a",
@@ -45779,10 +46210,6 @@
"sub" : "http://purl.obolibrary.org/obo/UBERON_0003061",
"pred" : "http://purl.obolibrary.org/obo/RO_0002387",
"obj" : "http://purl.obolibrary.org/obo/UBERON_0002390"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/UBERON_0003068",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000000"
}, {
"sub" : "http://purl.obolibrary.org/obo/UBERON_0003068",
"pred" : "is_a",
@@ -45799,10 +46226,6 @@
"sub" : "http://purl.obolibrary.org/obo/UBERON_0003068",
"pred" : "http://purl.obolibrary.org/obo/RO_0002202",
"obj" : "http://purl.obolibrary.org/obo/UBERON_0000926"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/UBERON_0003075",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000006"
}, {
"sub" : "http://purl.obolibrary.org/obo/UBERON_0003075",
"pred" : "is_a",
@@ -45924,10 +46347,6 @@
"sub" : "http://purl.obolibrary.org/obo/UBERON_0003081",
"pred" : "http://purl.obolibrary.org/obo/RO_0002221",
"obj" : "http://purl.obolibrary.org/obo/UBERON_0003887"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/UBERON_0003084",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000000"
}, {
"sub" : "http://purl.obolibrary.org/obo/UBERON_0003084",
"pred" : "is_a",
@@ -46032,10 +46451,6 @@
"sub" : "http://purl.obolibrary.org/obo/UBERON_0003104",
"pred" : "http://purl.obolibrary.org/obo/RO_0002473",
"obj" : "http://purl.obolibrary.org/obo/CL_0008019"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/UBERON_0003886",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000000"
}, {
"sub" : "http://purl.obolibrary.org/obo/UBERON_0003886",
"pred" : "is_a",
@@ -46056,10 +46471,6 @@
"sub" : "http://purl.obolibrary.org/obo/UBERON_0003886",
"pred" : "http://purl.obolibrary.org/obo/RO_0002492",
"obj" : "http://purl.obolibrary.org/obo/UBERON_0000111"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/UBERON_0003887",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000000"
}, {
"sub" : "http://purl.obolibrary.org/obo/UBERON_0003887",
"pred" : "is_a",
@@ -46098,10 +46509,6 @@
"sub" : "http://purl.obolibrary.org/obo/UBERON_0004111",
"pred" : "http://purl.obolibrary.org/obo/RO_0002570",
"obj" : "http://purl.obolibrary.org/obo/UBERON_0000061"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/UBERON_0004120",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000000"
}, {
"sub" : "http://purl.obolibrary.org/obo/UBERON_0004120",
"pred" : "is_a",
@@ -46110,10 +46517,6 @@
"sub" : "http://purl.obolibrary.org/obo/UBERON_0004120",
"pred" : "http://purl.obolibrary.org/obo/RO_0002202",
"obj" : "http://purl.obolibrary.org/obo/UBERON_0000926"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/UBERON_0004121",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000000"
}, {
"sub" : "http://purl.obolibrary.org/obo/UBERON_0004121",
"pred" : "is_a",
@@ -46122,10 +46525,6 @@
"sub" : "http://purl.obolibrary.org/obo/UBERON_0004121",
"pred" : "http://purl.obolibrary.org/obo/RO_0002202",
"obj" : "http://purl.obolibrary.org/obo/UBERON_0000924"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/UBERON_0004139",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000000"
}, {
"sub" : "http://purl.obolibrary.org/obo/UBERON_0004139",
"pred" : "is_a",
@@ -46216,10 +46615,6 @@
"sub" : "http://purl.obolibrary.org/obo/UBERON_0004291",
"pred" : "http://purl.obolibrary.org/obo/RO_0002202",
"obj" : "http://purl.obolibrary.org/obo/UBERON_0004139"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/UBERON_0004535",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000006"
}, {
"sub" : "http://purl.obolibrary.org/obo/UBERON_0004535",
"pred" : "is_a",
@@ -46240,10 +46635,6 @@
"sub" : "http://purl.obolibrary.org/obo/UBERON_0004535",
"pred" : "http://purl.obolibrary.org/obo/BFO_0000051",
"obj" : "http://purl.obolibrary.org/obo/UBERON_0001981"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/UBERON_0004537",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000000"
}, {
"sub" : "http://purl.obolibrary.org/obo/UBERON_0004537",
"pred" : "is_a",
@@ -46264,10 +46655,6 @@
"sub" : "http://purl.obolibrary.org/obo/UBERON_0004638",
"pred" : "http://purl.obolibrary.org/obo/BFO_0000050",
"obj" : "http://purl.obolibrary.org/obo/UBERON_0001981"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/UBERON_0004716",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000000"
}, {
"sub" : "http://purl.obolibrary.org/obo/UBERON_0004716",
"pred" : "is_a",
@@ -46292,10 +46679,6 @@
"sub" : "http://purl.obolibrary.org/obo/UBERON_0004716",
"pred" : "http://purl.obolibrary.org/obo/RO_0002493",
"obj" : "http://purl.obolibrary.org/obo/UBERON_0000068"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/UBERON_0004734",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000000"
}, {
"sub" : "http://purl.obolibrary.org/obo/UBERON_0004734",
"pred" : "is_a",
@@ -46308,10 +46691,6 @@
"sub" : "http://purl.obolibrary.org/obo/UBERON_0004734",
"pred" : "http://purl.obolibrary.org/obo/RO_0002491",
"obj" : "http://purl.obolibrary.org/obo/UBERON_0000109"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/UBERON_0004755",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000000"
}, {
"sub" : "http://purl.obolibrary.org/obo/UBERON_0004755",
"pred" : "is_a",
@@ -46486,10 +46865,6 @@
"sub" : "http://purl.obolibrary.org/obo/UBERON_0005068",
"pred" : "http://purl.obolibrary.org/obo/RO_0002202",
"obj" : "http://purl.obolibrary.org/obo/UBERON_0007135"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/UBERON_0005090",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000000"
}, {
"sub" : "http://purl.obolibrary.org/obo/UBERON_0005090",
"pred" : "is_a",
@@ -46666,10 +47041,6 @@
"val" : "AEO-modified-relation"
} ]
}
- }, {
- "sub" : "http://purl.obolibrary.org/obo/UBERON_0005944",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000000"
}, {
"sub" : "http://purl.obolibrary.org/obo/UBERON_0005944",
"pred" : "is_a",
@@ -46718,10 +47089,6 @@
"val" : "EHDAA2"
} ]
}
- }, {
- "sub" : "http://purl.obolibrary.org/obo/UBERON_0006268",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000000"
}, {
"sub" : "http://purl.obolibrary.org/obo/UBERON_0006268",
"pred" : "is_a",
@@ -46780,10 +47147,6 @@
"sub" : "http://purl.obolibrary.org/obo/UBERON_0006596",
"pred" : "http://purl.obolibrary.org/obo/RO_0002387",
"obj" : "http://purl.obolibrary.org/obo/UBERON_0000178"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/UBERON_0006598",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000000"
}, {
"sub" : "http://purl.obolibrary.org/obo/UBERON_0006598",
"pred" : "is_a",
@@ -46832,10 +47195,6 @@
"sub" : "http://purl.obolibrary.org/obo/UBERON_0006914",
"pred" : "http://purl.obolibrary.org/obo/BFO_0000051",
"obj" : "http://purl.obolibrary.org/obo/CL_0000076"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/UBERON_0006965",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000006"
}, {
"sub" : "http://purl.obolibrary.org/obo/UBERON_0006965",
"pred" : "is_a",
@@ -46870,10 +47229,6 @@
"val" : "via morphological boundary in CARO"
} ]
}
- }, {
- "sub" : "http://purl.obolibrary.org/obo/UBERON_0007005",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000006"
}, {
"sub" : "http://purl.obolibrary.org/obo/UBERON_0007005",
"pred" : "is_a",
@@ -47021,10 +47376,6 @@
"val" : "AEO"
} ]
}
- }, {
- "sub" : "http://purl.obolibrary.org/obo/UBERON_0007524",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000000"
}, {
"sub" : "http://purl.obolibrary.org/obo/UBERON_0007524",
"pred" : "is_a",
@@ -47116,10 +47467,6 @@
"sub" : "http://purl.obolibrary.org/obo/UBERON_0007811",
"pred" : "http://purl.obolibrary.org/obo/BFO_0000051",
"obj" : "http://purl.obolibrary.org/obo/UBERON_0006562"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/UBERON_0009142",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000000"
}, {
"sub" : "http://purl.obolibrary.org/obo/UBERON_0009142",
"pred" : "is_a",
@@ -47204,10 +47551,6 @@
"val" : "CARO"
} ]
}
- }, {
- "sub" : "http://purl.obolibrary.org/obo/UBERON_0010210",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000000"
}, {
"sub" : "http://purl.obolibrary.org/obo/UBERON_0010210",
"pred" : "is_a",
@@ -47246,10 +47589,6 @@
"sub" : "http://purl.obolibrary.org/obo/UBERON_0010210",
"pred" : "http://purl.obolibrary.org/obo/RO_0002353",
"obj" : "http://purl.obolibrary.org/obo/GO_0007596"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/UBERON_0010314",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000000"
}, {
"sub" : "http://purl.obolibrary.org/obo/UBERON_0010314",
"pred" : "is_a",
@@ -47258,10 +47597,6 @@
"sub" : "http://purl.obolibrary.org/obo/UBERON_0010314",
"pred" : "http://purl.obolibrary.org/obo/RO_0002254",
"obj" : "http://purl.obolibrary.org/obo/UBERON_0002342"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/UBERON_0010316",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000000"
}, {
"sub" : "http://purl.obolibrary.org/obo/UBERON_0010316",
"pred" : "is_a",
@@ -47316,10 +47651,6 @@
"val" : "VSAO"
} ]
}
- }, {
- "sub" : "http://purl.obolibrary.org/obo/UBERON_0011137",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000006"
}, {
"sub" : "http://purl.obolibrary.org/obo/UBERON_0011137",
"pred" : "is_a",
@@ -47338,10 +47669,6 @@
"sub" : "http://purl.obolibrary.org/obo/UBERON_0011137",
"pred" : "http://purl.obolibrary.org/obo/BFO_0000051",
"obj" : "http://purl.obolibrary.org/obo/UBERON_0005944"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/UBERON_0011138",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000006"
}, {
"sub" : "http://purl.obolibrary.org/obo/UBERON_0011138",
"pred" : "is_a",
@@ -47516,10 +47843,6 @@
"sub" : "http://purl.obolibrary.org/obo/UBERON_0014477",
"pred" : "http://purl.obolibrary.org/obo/BFO_0000050",
"obj" : "http://purl.obolibrary.org/obo/UBERON_0002090"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/UBERON_0014903",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000000"
}, {
"sub" : "http://purl.obolibrary.org/obo/UBERON_0014903",
"pred" : "is_a",
@@ -47690,10 +48013,6 @@
"sub" : "http://purl.obolibrary.org/obo/UBERON_0034925",
"pred" : "http://purl.obolibrary.org/obo/RO_0002351",
"obj" : "http://purl.obolibrary.org/obo/UBERON_0000061"
- }, {
- "sub" : "http://purl.obolibrary.org/obo/UBERON_0035804",
- "pred" : "is_a",
- "obj" : "http://purl.obolibrary.org/obo/CARO_0000000"
}, {
"sub" : "http://purl.obolibrary.org/obo/UBERON_0035804",
"pred" : "is_a",
@@ -48826,6 +49145,10 @@
"sub" : "http://purl.obolibrary.org/obo/RO_0015016",
"pred" : "subPropertyOf",
"obj" : "http://purl.obolibrary.org/obo/RO_0002104"
+ }, {
+ "sub" : "http://purl.obolibrary.org/obo/RO_0017003",
+ "pred" : "subPropertyOf",
+ "obj" : "http://purl.obolibrary.org/obo/RO_0002610"
}, {
"sub" : "http://purl.obolibrary.org/obo/RO_0019000",
"pred" : "subPropertyOf",
@@ -52680,7 +53003,6 @@
} ]
}, {
"predicateId" : "http://purl.obolibrary.org/obo/RO_0002162",
- "rangeClassIds" : [ "http://purl.obolibrary.org/obo/CARO_0001010" ],
"allValuesFromEdges" : [ {
"sub" : "http://purl.obolibrary.org/obo/GO_0000278",
"pred" : "http://purl.obolibrary.org/obo/RO_0002162",
@@ -52811,7 +53133,7 @@
"rangeClassIds" : [ "http://purl.obolibrary.org/obo/BFO_0000141" ]
}, {
"predicateId" : "http://purl.obolibrary.org/obo/RO_0002005",
- "domainClassIds" : [ "http://purl.obolibrary.org/obo/CARO_0000003" ]
+ "domainClassIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000061" ]
}, {
"predicateId" : "http://purl.obolibrary.org/obo/RO_0002018",
"domainClassIds" : [ "http://purl.obolibrary.org/obo/BFO_0000015" ],
@@ -52819,7 +53141,7 @@
}, {
"predicateId" : "http://purl.obolibrary.org/obo/RO_0002100",
"domainClassIds" : [ "http://purl.obolibrary.org/obo/CL_0000540" ],
- "rangeClassIds" : [ "http://purl.obolibrary.org/obo/CARO_0000003" ]
+ "rangeClassIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000465" ]
}, {
"predicateId" : "http://purl.obolibrary.org/obo/RO_0002101",
"domainClassIds" : [ "http://purl.obolibrary.org/obo/CL_0000540" ]
@@ -52828,8 +53150,8 @@
"domainClassIds" : [ "http://purl.obolibrary.org/obo/CL_0000540" ]
}, {
"predicateId" : "http://purl.obolibrary.org/obo/RO_0002104",
- "domainClassIds" : [ "http://purl.obolibrary.org/obo/CARO_0000006" ],
- "rangeClassIds" : [ "http://purl.obolibrary.org/obo/CARO_0000006" ]
+ "domainClassIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000465" ],
+ "rangeClassIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000465" ]
}, {
"predicateId" : "http://purl.obolibrary.org/obo/RO_0002110",
"domainClassIds" : [ "http://purl.obolibrary.org/obo/CL_0000540" ]
@@ -52848,8 +53170,8 @@
"domainClassIds" : [ "http://purl.obolibrary.org/obo/BFO_0000004" ]
}, {
"predicateId" : "http://purl.obolibrary.org/obo/RO_0002177",
- "domainClassIds" : [ "http://purl.obolibrary.org/obo/CARO_0000003" ],
- "rangeClassIds" : [ "http://purl.obolibrary.org/obo/CARO_0000003" ]
+ "domainClassIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000061" ],
+ "rangeClassIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000061" ]
}, {
"predicateId" : "http://purl.obolibrary.org/obo/RO_0002202",
"domainClassIds" : [ "http://purl.obolibrary.org/obo/BFO_0000004" ],
@@ -52857,7 +53179,7 @@
}, {
"predicateId" : "http://purl.obolibrary.org/obo/RO_0002206",
"domainClassIds" : [ "http://purl.obolibrary.org/obo/BFO_0000002" ],
- "rangeClassIds" : [ "http://purl.obolibrary.org/obo/CARO_0000006" ]
+ "rangeClassIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000465" ]
}, {
"predicateId" : "http://purl.obolibrary.org/obo/RO_0002211",
"domainClassIds" : [ "http://purl.obolibrary.org/obo/BFO_0000015" ],
@@ -52876,7 +53198,7 @@
"rangeClassIds" : [ "http://purl.obolibrary.org/obo/BFO_0000003" ]
}, {
"predicateId" : "http://purl.obolibrary.org/obo/RO_0002226",
- "domainClassIds" : [ "http://purl.obolibrary.org/obo/CARO_0000000" ]
+ "domainClassIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001062" ]
}, {
"predicateId" : "http://purl.obolibrary.org/obo/RO_0002231",
"domainClassIds" : [ "http://purl.obolibrary.org/obo/BFO_0000015" ],
@@ -52890,12 +53212,12 @@
"domainClassIds" : [ "http://purl.obolibrary.org/obo/BFO_0000015" ]
}, {
"predicateId" : "http://purl.obolibrary.org/obo/RO_0002254",
- "domainClassIds" : [ "http://purl.obolibrary.org/obo/CARO_0000000" ],
- "rangeClassIds" : [ "http://purl.obolibrary.org/obo/CARO_0000000" ]
+ "domainClassIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001062" ],
+ "rangeClassIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001062" ]
}, {
"predicateId" : "http://purl.obolibrary.org/obo/RO_0002256",
- "domainClassIds" : [ "http://purl.obolibrary.org/obo/CARO_0000006" ],
- "rangeClassIds" : [ "http://purl.obolibrary.org/obo/CARO_0000006" ]
+ "domainClassIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000465" ],
+ "rangeClassIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000465" ]
}, {
"predicateId" : "http://purl.obolibrary.org/obo/RO_0002258",
"domainClassIds" : [ "http://purl.obolibrary.org/obo/BFO_0000002" ],
@@ -52903,7 +53225,7 @@
}, {
"predicateId" : "http://purl.obolibrary.org/obo/RO_0002295",
"domainClassIds" : [ "http://purl.obolibrary.org/obo/GO_0008150" ],
- "rangeClassIds" : [ "http://purl.obolibrary.org/obo/CARO_0000000" ]
+ "rangeClassIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001062" ]
}, {
"predicateId" : "http://purl.obolibrary.org/obo/RO_0002330",
"domainClassIds" : [ "http://purl.obolibrary.org/obo/BFO_0000002" ],
@@ -52922,18 +53244,18 @@
"rangeClassIds" : [ "http://purl.obolibrary.org/obo/BFO_0000002" ]
}, {
"predicateId" : "http://purl.obolibrary.org/obo/RO_0002372",
- "domainClassIds" : [ "http://purl.obolibrary.org/obo/CARO_0000003" ]
+ "domainClassIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000061" ]
}, {
"predicateId" : "http://purl.obolibrary.org/obo/RO_0002373",
- "domainClassIds" : [ "http://purl.obolibrary.org/obo/CARO_0000003" ]
+ "domainClassIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000061" ]
}, {
"predicateId" : "http://purl.obolibrary.org/obo/RO_0002375",
"domainClassIds" : [ "http://purl.obolibrary.org/obo/BFO_0000040" ],
"rangeClassIds" : [ "http://purl.obolibrary.org/obo/BFO_0000040" ]
}, {
"predicateId" : "http://purl.obolibrary.org/obo/RO_0002384",
- "domainClassIds" : [ "http://purl.obolibrary.org/obo/CARO_0000000" ],
- "rangeClassIds" : [ "http://purl.obolibrary.org/obo/CARO_0000000" ]
+ "domainClassIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001062" ],
+ "rangeClassIds" : [ "http://purl.obolibrary.org/obo/UBERON_0001062" ]
}, {
"predicateId" : "http://purl.obolibrary.org/obo/RO_0002434",
"domainClassIds" : [ "http://purl.obolibrary.org/obo/BFO_0000040" ],
@@ -52972,16 +53294,16 @@
"rangeClassIds" : [ "http://purl.obolibrary.org/obo/BFO_0000002" ]
}, {
"predicateId" : "http://purl.obolibrary.org/obo/RO_0002551",
- "domainClassIds" : [ "http://purl.obolibrary.org/obo/CARO_0000003", "http://purl.obolibrary.org/obo/UBERON_0000475" ],
- "rangeClassIds" : [ "http://purl.obolibrary.org/obo/CARO_0000006", "http://purl.obolibrary.org/obo/UBERON_0010912" ]
+ "domainClassIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000061", "http://purl.obolibrary.org/obo/UBERON_0000475" ],
+ "rangeClassIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000465", "http://purl.obolibrary.org/obo/UBERON_0010912" ]
}, {
"predicateId" : "http://purl.obolibrary.org/obo/RO_0002566",
"domainClassIds" : [ "http://purl.obolibrary.org/obo/BFO_0000002" ],
"rangeClassIds" : [ "http://purl.obolibrary.org/obo/BFO_0000002" ]
}, {
"predicateId" : "http://purl.obolibrary.org/obo/RO_0002567",
- "domainClassIds" : [ "http://purl.obolibrary.org/obo/CARO_0000003" ],
- "rangeClassIds" : [ "http://purl.obolibrary.org/obo/CARO_0000003" ]
+ "domainClassIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000061" ],
+ "rangeClassIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000061" ]
}, {
"predicateId" : "http://purl.obolibrary.org/obo/RO_0002570",
"domainClassIds" : [ "http://purl.obolibrary.org/obo/BFO_0000040" ],
@@ -52991,8 +53313,8 @@
"domainClassIds" : [ "http://purl.obolibrary.org/obo/BFO_0000141" ]
}, {
"predicateId" : "http://purl.obolibrary.org/obo/RO_0002576",
- "domainClassIds" : [ "http://purl.obolibrary.org/obo/CARO_0000003" ],
- "rangeClassIds" : [ "http://purl.obolibrary.org/obo/CARO_0000003" ]
+ "domainClassIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000061" ],
+ "rangeClassIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000061" ]
}, {
"predicateId" : "http://purl.obolibrary.org/obo/RO_0002595",
"domainClassIds" : [ "http://purl.obolibrary.org/obo/BFO_0000040" ],
@@ -53043,7 +53365,7 @@
"rangeClassIds" : [ "http://purl.obolibrary.org/obo/BFO_0000040" ]
}, {
"predicateId" : "http://purl.obolibrary.org/obo/RO_0002315",
- "rangeClassIds" : [ "http://purl.obolibrary.org/obo/CARO_0000003" ]
+ "rangeClassIds" : [ "http://purl.obolibrary.org/obo/UBERON_0000061" ]
}, {
"predicateId" : "http://purl.obolibrary.org/obo/RO_0002571",
"rangeClassIds" : [ "http://purl.obolibrary.org/obo/BFO_0000040" ]
diff --git a/src/ontology/subsets/blood_and_immune_upper_slim.obo b/src/ontology/subsets/blood_and_immune_upper_slim.obo
index 3f4dc7a74..af88c78d1 100644
--- a/src/ontology/subsets/blood_and_immune_upper_slim.obo
+++ b/src/ontology/subsets/blood_and_immune_upper_slim.obo
@@ -1,5 +1,5 @@
format-version: 1.2
-data-version: cl/releases/2023-06-22/subsets/blood_and_immune_upper_slim.owl
+data-version: cl/releases/2023-07-20/subsets/blood_and_immune_upper_slim.owl
subsetdef: abnormal_slim ""
subsetdef: added_for_HCA ""
subsetdef: attribute_slim ""
@@ -82,7 +82,7 @@ synonymtypedef: INCONSISTENT ""
synonymtypedef: IUPAC_NAME ""
synonymtypedef: LATIN ""
synonymtypedef: LATIN "latin term"
-synonymtypedef: MISSPELLING ""
+synonymtypedef: MISSPELLING "a mis-spelling that is in common use and thus recorded"
synonymtypedef: NON_MAMMAL ""
synonymtypedef: PENDING_REVIEW ""
synonymtypedef: PLURAL "plural term"
@@ -95,7 +95,7 @@ synonymtypedef: synonym ""
synonymtypedef: SYSTEMATIC ""
synonymtypedef: systematic_synonym ""
ontology: cl/subsets/blood_and_immune_upper_slim
-property_value: owl:versionInfo "2023-06-22" xsd:string
+property_value: owl:versionInfo "2023-07-20" xsd:string
[Term]
id: BFO:0000002
@@ -113,7 +113,8 @@ relationship: part_of BFO:0000003 {all_only="true"} ! occurrent
[Term]
id: BFO:0000004
name: independent continuant
-def: "A continuant that is a bearer of quality and realizable entity entities, in which other entities inhere and which itself cannot inhere in anything." []
+def: "b is an independent continuant = Def. b is a continuant which is such that there is no c and no t such that b s-depends_on c at t. (axiom label in BFO2 Reference: [017-002])" []
+comment: A continuant that is a bearer of quality and realizable entity entities, in which other entities inhere and which itself cannot inhere in anything.
is_a: BFO:0000002 ! continuant
disjoint_from: BFO:0000020 ! specifically dependent continuant
relationship: part_of BFO:0000004 {all_only="true"} ! independent continuant
@@ -121,13 +122,15 @@ relationship: part_of BFO:0000004 {all_only="true"} ! independent continuant
[Term]
id: BFO:0000015
name: process
-def: "An occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t." []
+def: "p is a process = Def. p is an occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t. (axiom label in BFO2 Reference: [083-003])" []
+comment: An occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t.
is_a: BFO:0000003 ! occurrent
[Term]
id: BFO:0000020
name: specifically dependent continuant
-def: "A continuant that inheres in or is borne by other entities. Every instance of A requires some specific instance of B which must always be the same." []
+def: "b is a specifically dependent continuant = Def. b is a continuant & there is some independent continuant c which is not a spatial region and which is such that b s-depends_on c at every time t during the course of b’s existence. (axiom label in BFO2 Reference: [050-003])" []
+comment: A continuant that inheres in or is borne by other entities. Every instance of A requires some specific instance of B which must always be the same.
is_a: BFO:0000002 ! continuant
relationship: part_of BFO:0000020 {all_only="true"} ! specifically dependent continuant
@@ -376,7 +379,6 @@ synonym: "colony forming unit monocyte" RELATED []
synonym: "monocyte stem cell" RELATED []
xref: CALOHA:TS-1195
xref: FMA:83553
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0000763 ! myeloid cell
is_a: CL:0002194 {is_inferred="true"} ! monopoietic cell
is_a: PR:000050567 ! protein-containing material entity
@@ -518,7 +520,6 @@ xref: CALOHA:TS-0362
xref: FMA:63877
xref: NCIT:C12482
xref: VHOG:0001482
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:0002320 ! connective tissue cell
relationship: develops_from CL:0000134 ! mesenchymal stem cell
relationship: present_in_taxon NCBITaxon:9606
@@ -616,7 +617,6 @@ xref: BTO:0000968
xref: CALOHA:TS-0721
xref: FMA:66781
xref: MESH:D010010
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0000766 {is_inferred="true"} ! myeloid leukocyte
is_a: CL:0001035 {is_inferred="true"} ! bone cell
is_a: PR:000050567 ! protein-containing material entity
@@ -652,7 +652,6 @@ xref: BTO:0000539
xref: BTO:0001026
xref: CALOHA:TS-0422
xref: FMA:62854
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0000081 ! blood cell
is_a: CL:0000766 {is_inferred="true"} ! myeloid leukocyte
is_a: PR:000050567 ! protein-containing material entity
@@ -690,7 +689,6 @@ synonym: "tissue basophil" RELATED [ISBN:068340007X]
xref: BTO:0000830
xref: CALOHA:TS-0603
xref: FMA:66784
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0000766 {is_inferred="true"} ! myeloid leukocyte
is_a: CL:0002274 ! histamine secreting cell
is_a: PR:000050567 ! protein-containing material entity
@@ -810,7 +808,6 @@ xref: CALOHA:TS-2032
xref: FBbt:00005074
xref: FMA:67328
xref: WBbt:0003675
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:0000183 ! contractile cell
is_a: CL:0000393 ! electrically responsive cell
is_a: CL:0002371 ! somatic cell
@@ -1200,7 +1197,6 @@ subset: blood_and_immune_upper_slim
synonym: "pronormoblast" RELATED []
synonym: "rubriblast" EXACT [ISBN:0721601464]
xref: FMA:83518
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0000764 {is_inferred="true"} ! erythroid lineage cell
is_a: CL:0002242 ! nucleate cell
is_a: PR:000050567 ! protein-containing material entity
@@ -1258,7 +1254,6 @@ synonym: "early erythroblast" EXACT [ISBN:0721601464]
synonym: "early normoblast" EXACT [ISBN:0721601464]
synonym: "prorubricyte" EXACT [ISBN:0721601464]
xref: FMA:83505
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0000765 {is_inferred="true"} ! erythroblast
is_a: PR:000050567 ! protein-containing material entity
intersection_of: CL:0000765 ! erythroblast
@@ -1280,7 +1275,6 @@ synonym: "polychromatic normoblast" EXACT [ISBN:0721601464]
synonym: "polychromatophilic normoblast" EXACT [ISBN:0721601464]
synonym: "rubricyte" EXACT [ISBN:0721601464]
xref: FMA:83506
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0000765 {is_inferred="true"} ! erythroblast
is_a: PR:000050567 ! protein-containing material entity
intersection_of: CL:0000765 ! erythroblast
@@ -1396,7 +1390,6 @@ synonym: "GMP" EXACT [ISBN:0721601464, PMCID:PMC2213186, PMCID:PMC548021]
synonym: "granulocyte-macrophage progenitor" EXACT [ISBN:0721601464, PMCID:PMC2213186, PMCID:PMC548021]
synonym: "granulocyte/monocyte precursor" EXACT []
synonym: "granulocyte/monocyte progenitor" EXACT []
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0000763 ! myeloid cell
is_a: CL:0001012 ! CD7-negative lymphoid progenitor OR granulocyte monocyte progenitor
is_a: CL:0011026 ! progenitor cell
@@ -1428,7 +1421,6 @@ subset: blood_and_immune_upper_slim
xref: BTO:0001173
xref: CALOHA:TS-0864
xref: MESH:D012156
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0000764 {is_inferred="true"} ! erythroid lineage cell
is_a: PR:000050567 ! protein-containing material entity
intersection_of: CL:0000764 ! erythroid lineage cell
@@ -1468,7 +1460,6 @@ comment: Morphology: Mononuclear cell, diameter 14-18 _M, fine azurophilic granu
subset: human_reference_atlas
xref: BTO:0004657
xref: FMA:83551
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0000763 ! myeloid cell
is_a: CL:0002194 {is_inferred="true"} ! monopoietic cell
is_a: PR:000050567 ! protein-containing material entity
@@ -1489,7 +1480,6 @@ comment: These cells are reportedly CD31-positive, CD34-positive, CD144-positive
subset: human_reference_atlas
synonym: "angioblast" EXACT []
synonym: "chondroplast" EXACT []
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0000134 {is_inferred="true"} ! mesenchymal stem cell
is_a: CL:0011026 ! progenitor cell
is_a: PR:000050567 ! protein-containing material entity
@@ -1556,7 +1546,6 @@ relationship: participates_in GO:0002544 ! chronic inflammatory response
id: CL:0000680
name: muscle precursor cell
def: "A non-terminally differentiated cell that is capable of developing into a muscle cell." [GOC:add]
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:0000055 ! non-terminally differentiated cell
is_a: CL:0002371 ! somatic cell
intersection_of: CL:0011115 ! precursor cell
@@ -1590,7 +1579,6 @@ xref: CALOHA:TS-0549
xref: FMA:62852
xref: MESH:D007962
xref: NCIT:C12529
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:0000219 ! motile cell
is_a: CL:0000988 {is_inferred="true"} ! hematopoietic cell
is_a: CL:0002242 ! nucleate cell
@@ -1624,7 +1612,6 @@ def: "A cell of the monocyte, granulocyte, mast cell, megakaryocyte, or erythroi
xref: BTO:0001441
xref: CALOHA:TS-0647
xref: MESH:D022423
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:0000988 {is_inferred="true"} ! hematopoietic cell
intersection_of: CL:0000988 ! hematopoietic cell
intersection_of: develops_from CL:0000049 ! common myeloid progenitor
@@ -1865,7 +1852,6 @@ synonym: "plasmocyte" EXACT []
xref: BTO:0000392
xref: FMA:70574
xref: MESH:D010950
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0000946 {is_inferred="true"} ! antibody secreting cell
intersection_of: CL:0000946 ! antibody secreting cell
intersection_of: CL:4030046 GO:0019814 ! lacks_plasma_membrane_part immunoglobulin complex
@@ -1891,7 +1877,6 @@ subset: blood_and_immune_upper_slim
synonym: "alpha-beta T lymphocyte" EXACT []
synonym: "alpha-beta T-cell" EXACT []
synonym: "alpha-beta T-lymphocyte" EXACT []
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0000084 {is_inferred="true"} ! T cell
intersection_of: CL:0000084 ! T cell
intersection_of: RO:0002104 GO:0042105 ! has plasma membrane part alpha-beta T cell receptor complex
@@ -1910,7 +1895,6 @@ synonym: "gamma-delta T-cell" EXACT []
synonym: "gamma-delta T-lymphocyte" EXACT []
synonym: "gammadelta T cell" EXACT []
synonym: "gd T cell" RELATED []
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0000084 {is_inferred="true"} ! T cell
intersection_of: CL:0000084 ! T cell
intersection_of: RO:0002104 GO:0042106 ! has plasma membrane part gamma-delta T cell receptor complex
@@ -2052,7 +2036,6 @@ synonym: "CFU-Mast" RELATED []
synonym: "CFU-MC" RELATED []
synonym: "colony forming unit mast cell" RELATED []
synonym: "MCP" EXACT []
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0000763 ! myeloid cell
is_a: CL:0000839 {is_inferred="true"} ! myeloid lineage restricted progenitor cell
is_a: PR:000050567 ! protein-containing material entity
@@ -2118,7 +2101,6 @@ synonym: "hemopoietic progenitor cell" EXACT []
synonym: "MPP" EXACT []
xref: BTO:0000725
xref: CALOHA:TS-0448
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0008001 ! hematopoietic precursor cell
is_a: PR:000050567 ! protein-containing material entity
intersection_of: CL:0000988 ! hematopoietic cell
@@ -2208,7 +2190,6 @@ name: myeloid suppressor cell
def: "An immature myeloid leukocyte of heterogeneous phenotype found particularly in cancer and sepsis patients that is capable of suppressing activity of T cells in ex vivo assays. This cell type is CD45-positive, CD11b-positive." [GO_REF:0000031, GOC:add, GOC:ana, PMID:16168663, PMID:17016554, PMID:17016559]
comment: Markers: Mouse: CD11b+GR1+CD31+; Human: CD34+ CD33+CD15-CD13+. (According to some reports in humans these cells are iNOS+ARG1+IL13+IFNg+); location: In cancerous tissue; in the blood and lymphoid organs in sepsis.
subset: blood_and_immune_upper_slim
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0000766 {is_inferred="true"} ! myeloid leukocyte
is_a: PR:000050567 ! protein-containing material entity
intersection_of: CL:0000766 ! myeloid leukocyte
@@ -2328,7 +2309,6 @@ synonym: "interdigitating cell" BROAD []
synonym: "type 1 DC" EXACT []
synonym: "veiled cell" BROAD []
xref: FMA:84191
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0000451 {is_inferred="true"} ! dendritic cell
intersection_of: CL:0000451 ! dendritic cell
intersection_of: RO:0015015 PR:000001013 ! has high plasma membrane amount integrin alpha-X
@@ -2414,7 +2394,6 @@ id: CL:0001200
name: lymphocyte of B lineage, CD19-positive
def: "A lymphocyte of B lineage that is CD19-positive." [GOC:add]
comment: Types of B lineage lymphocytes include B cells and antibody secreting cells (plasmablasts and plasma cells). Lymphocytes of B cell lineage can be distinguished from those of T cell lineage by their lack of CD3e (as part of the T cell receptor complex).
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0000945 ! lymphocyte of B lineage
intersection_of: CL:0000945 ! lymphocyte of B lineage
intersection_of: CL:4030046 PR:000001020 ! lacks_plasma_membrane_part CD3 epsilon
@@ -2465,7 +2444,6 @@ name: basophil mast progenitor cell
def: "A cell type that can give rise to basophil and mast cells. This cell is CD34-positive, CD117-positive, CD125-positive, FceRIa-negative, and T1/ST2-negative, and expresses Gata-1, Gata-2, C/EBPa" [GOC:ak, GOC:dsd, GOC:tfm, PMCID:PMC1312421]
comment: There may be an intermediate cell type. These cells also CD13-positive, CD16-positive, CD32-positive, and integrin beta 7-positive. Transcription factors: GATA1-positive, MCP-1-positive, mitf-positive, PU.1-positive, and CEBP/a-low.
synonym: "BMCP" EXACT []
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0000763 ! myeloid cell
is_a: CL:0002191 ! granulocytopoietic cell
is_a: PR:000050567 ! protein-containing material entity
@@ -2495,7 +2473,6 @@ id: CL:0002031
name: hematopoietic lineage restricted progenitor cell
def: "A hematopoietic progenitor cell that is capable of developing into only one lineage of hematopoietic cells." [GOC:tfm, PMID:19022770]
subset: blood_and_immune_upper_slim
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:0008001 ! hematopoietic precursor cell
intersection_of: CL:0000988 ! hematopoietic cell
intersection_of: bearer_of PATO:0001400 ! unipotent
@@ -2511,7 +2488,6 @@ name: hematopoietic oligopotent progenitor cell
def: "A hematopoietic oligopotent progenitor cell that has the ability to differentiate into limited cell types but lacks lineage cell markers and self renewal capabilities." [GOC:tfm, https://orcid.org/0000-0001-5208-3432, PMID:19022770]
comment: This cell type is intended to be compatible with any vertebrate hematopoietic oligopotent progenitor cell. For mammalian hematopoietic oligopotent progenitor cells known to be lineage-negative, please use the term 'hematopoietic oligopotent progenitor cell' (CL_0001060).
subset: blood_and_immune_upper_slim
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:0008001 ! hematopoietic precursor cell
intersection_of: CL:0000988 ! hematopoietic cell
intersection_of: bearer_of PATO:0001401 ! oligopotent
@@ -2525,7 +2501,6 @@ id: CL:0002077
name: ecto-epithelial cell
def: "An epithelial cell derived from ectoderm." [FMA:69074, GOC:tfm]
xref: FMA:69074
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:0000066 ! epithelial cell
is_a: CL:0002371 ! somatic cell
intersection_of: CL:0000066 ! epithelial cell
@@ -2540,7 +2515,6 @@ name: meso-epithelial cell
def: "Epithelial cell derived from mesoderm or mesenchyme." [FMA:69076, GOC:tfm]
synonym: "epithelial mesenchymal cell" EXACT []
xref: FMA:69076
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:0000066 ! epithelial cell
is_a: CL:0002371 ! somatic cell
intersection_of: CL:0000066 ! epithelial cell
@@ -2739,7 +2713,6 @@ id: CL:0002679
name: natural helper lymphocyte
def: "A lymphocyte found in adipose tissue that lacks lineage markers of other lymphocytes but is capable of mediating TH2 cytokine responses. This cell type is found in fat associated lymphoid clusters, proliferates in response to IL2 and produce large amounts of TH2 cytokines such as IL5, IL6 and IL13" [GOC:tfm, PMID:20023630]
subset: blood_and_immune_upper_slim
-is_a: CARO:0000006 ! material anatomical entity
is_a: CL:0000542 {is_inferred="true"} ! lymphocyte
intersection_of: CL:0000542 ! lymphocyte
intersection_of: CL:4030046 GO:0042105 ! lacks_plasma_membrane_part alpha-beta T cell receptor complex
@@ -2779,7 +2752,6 @@ creation_date: 2012-06-15T02:51:27Z
id: CL:0007004
name: premigratory neural crest cell
def: "Cell that is part of the neural crest region of the neuroepithelium, prior to migration. Note that not all premigratory neural crest cells may become migratory neural crest cells." [UBERONREF:0000002]
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:0011012 ! neural crest cell
relationship: dc-contributor https://orcid.org/0000-0001-9114-8737
relationship: develops_from CL:0000133 ! neurectodermal cell
@@ -2821,7 +2793,6 @@ is_a: CL:0002321 ! embryonic cell (metazoa)
id: CL:0011026
name: progenitor cell
def: "A precursor cell that has a tendency to differentiate into a specific type of cell. They are descendants of stem cells, only they are more constrained in their differentiation potential or capacity for self-renewal, and are often more limited in both senses." [https://doi.org/10.1016/B978-0-12-409503-8.00002-0, ISBN:978-1-62808-994-3]
-is_a: CARO:0000000 ! anatomical entity
is_a: CL:0011115 ! precursor cell
intersection_of: CL:0011115 ! precursor cell
intersection_of: develops_from CL:0000034 ! stem cell
@@ -9660,6 +9631,7 @@ synonym: "T200" BROAD [PRO:DNx]
xref: IUPHARobj:1852
xref: PIRSF:PIRSF002004
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P08575
[Term]
id: PR:000001012
@@ -9678,6 +9650,7 @@ synonym: "leukocyte adhesion receptor MO1" EXACT []
synonym: "neutrophil adherence receptor" EXACT []
xref: IUPHARobj:2452
is_a: PR:000001005 ! integrin alpha with A domain
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P11215
[Term]
id: PR:000001013
@@ -9694,6 +9667,7 @@ synonym: "leukocyte adhesion glycoprotein p150,95 alpha chain" EXACT []
synonym: "leukocyte adhesion receptor p150,95" EXACT []
xref: IUPHARobj:2454
is_a: PR:000001005 ! integrin alpha with A domain
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P20702
[Term]
id: PR:000001018
@@ -9749,6 +9723,7 @@ synonym: "NCAM-1" EXACT []
synonym: "NCAM1" EXACT PRO-short-label [PRO:DNx]
xref: IUPHARobj:2769
is_a: PR:000001023 ! neural cell adhesion molecule NCAM
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P13591
[Term]
id: PR:000001083
@@ -9785,6 +9760,7 @@ synonym: "MAL" RELATED Gene-based []
synonym: "T-cell surface glycoprotein Lyt-2" EXACT []
synonym: "T-lymphocyte differentiation antigen T8/Leu-2" EXACT []
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P01732
[Term]
id: PR:000001094
@@ -9840,6 +9816,7 @@ synonym: "RANTES-R" EXACT []
synonym: "SCYAR1" RELATED Gene-based []
xref: IUPHARobj:58
is_a: PR:000001197 ! chemokine receptor CCR1/3/1L
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P32246
[Term]
id: PR:000001255
@@ -9861,6 +9838,7 @@ synonym: "macrophage inflammatory protein 1-alpha receptor-like 2" EXACT []
synonym: "MIP-1 alpha RL2" EXACT []
xref: IUPHARobj:60
is_a: PR:000001197 ! chemokine receptor CCR1/3/1L
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P51677
[Term]
id: PR:000001281
@@ -9943,6 +9921,7 @@ synonym: "CEACAM8" EXACT PRO-short-label [PRO:DNx]
synonym: "CGM6" RELATED Gene-based []
synonym: "non-specific cross-reacting antigen NCA-95" EXACT []
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P31997
[Term]
id: PR:000001343
@@ -9979,6 +9958,7 @@ synonym: "PDNP3" RELATED Gene-based []
synonym: "phosphodiesterase I beta" EXACT []
synonym: "phosphodiesterase I/nucleotide pyrophosphatase 3" EXACT []
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:O14638
[Term]
id: PR:000001355
@@ -10017,6 +9997,7 @@ synonym: "NIM-R5 antigen" EXACT []
synonym: "T10" EXACT []
xref: IUPHARobj:2766
is_a: PR:000001281 ! ADP-ribosyl cyclase
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P28907
[Term]
id: PR:000001444
@@ -10030,6 +10011,7 @@ synonym: "CDH5" EXACT PRO-short-label [PRO:DNx]
synonym: "vascular endothelial cadherin" EXACT []
synonym: "VE-cadherin" EXACT []
is_a: PR:000001327 ! cadherin
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P33151
[Term]
id: PR:000001479
@@ -10081,6 +10063,7 @@ synonym: "lymphocyte antigen 1" EXACT []
synonym: "lymphocyte antigen T1/Leu-1" EXACT []
synonym: "Lyt-1" EXACT []
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P06127
[Term]
id: PR:000001850
@@ -10096,6 +10079,7 @@ synonym: "CTSO" RELATED Gene-based []
synonym: "CTSO2" RELATED Gene-based []
xref: IUPHARobj:2350
is_a: PR:000040662 ! cathepsin-like protease
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P43235
[Term]
id: PR:000001861
@@ -10141,6 +10125,7 @@ synonym: "IL5RA" EXACT PRO-short-label [PRO:DNx]
xref: IUPHARobj:1706
xref: PIRSF:PIRSF018419
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:Q01344
[Term]
id: PR:000001869
@@ -10158,6 +10143,7 @@ synonym: "IL7R" EXACT PRO-short-label [PRO:DNx]
xref: IUPHARobj:1698
xref: PIRSF:PIRSF001960
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P16871
[Term]
id: PR:000001874
@@ -10185,6 +10171,7 @@ synonym: "sialophorin" EXACT []
synonym: "SPN" EXACT PRO-short-label [PRO:DNx]
xref: PIRSF:PIRSF001994
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P16150
[Term]
id: PR:000001889
@@ -10219,6 +10206,7 @@ synonym: "skin fibroblast elastase" EXACT []
xref: IUPHARobj:1611
xref: PIRSF:PIRSF501074
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P08473
[Term]
id: PR:000001903
@@ -10231,6 +10219,7 @@ synonym: "BSAP" EXACT []
synonym: "Pax-5" RELATED Gene-based []
synonym: "PAX5" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:Q02548
[Term]
id: PR:000001932
@@ -10249,6 +10238,7 @@ synonym: "R13-Ag" EXACT []
synonym: "small cell lung carcinoma cluster 4 antigen" EXACT []
synonym: "X62 heat stable antigen" EXACT []
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P25063
[Term]
id: PR:000001935
@@ -10263,6 +10253,7 @@ synonym: "Synd-1" RELATED Gene-based []
synonym: "SYND1" EXACT []
xref: PIRSF:PIRSF015854
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P18827
[Term]
id: PR:000001937
@@ -10279,6 +10270,7 @@ synonym: "TrATPase" EXACT []
synonym: "type 5 acid phosphatase" EXACT []
xref: PIRSF:PIRSF000898
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P13686
[Term]
id: PR:000001944
@@ -10292,6 +10284,7 @@ synonym: "Sfpi-1" RELATED Gene-based []
synonym: "Sfpi1" RELATED Gene-based []
synonym: "SPI1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P17947
[Term]
id: PR:000001945
@@ -10308,6 +10301,7 @@ synonym: "TFRC" EXACT PRO-short-label [PRO:DNx]
synonym: "TR" RELATED []
synonym: "Trfr" RELATED Gene-based []
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P02786
[Term]
id: PR:000001950
@@ -10341,6 +10335,7 @@ synonym: "TNFRSF11A" EXACT PRO-short-label [PRO:DNx]
xref: IUPHARobj:1881
xref: PIRSF:PIRSF038806
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:Q9Y6Q6
[Term]
id: PR:000001963
@@ -10373,6 +10368,7 @@ synonym: "UPAR" RELATED Gene-based []
synonym: "uPAR" EXACT []
xref: PIRSF:PIRSF002022
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:Q03405
[Term]
id: PR:000001971
@@ -10401,6 +10397,7 @@ synonym: "proto-oncogene c-Fms" EXACT []
xref: IUPHARobj:1806
xref: PIRSF:PIRSF500947
is_a: PR:000001810 ! CSF-1/PDGF receptor-type tyrosine-protein kinase
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P07333
[Term]
id: PR:000002065
@@ -10436,6 +10433,7 @@ synonym: "VEGFR-2" EXACT []
synonym: "VEGFR2" RELATED Gene-based []
xref: IUPHARobj:1813
is_a: PR:000001971 ! vascular endothelial growth factor receptor
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P35968
[Term]
id: PR:000002976
@@ -10505,6 +10503,7 @@ synonym: "RAG1" EXACT PRO-short-label [PRO:DNx]
synonym: "RING finger protein 74" EXACT []
synonym: "RNF74" RELATED Gene-based []
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P15918
[Term]
id: PR:000003460
@@ -10515,6 +10514,7 @@ comment: Category=gene. Requested by=CL.
synonym: "RAG-2" EXACT []
synonym: "RAG2" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P55895
[Term]
id: PR:000005178
@@ -10547,6 +10547,7 @@ synonym: "C/EBP alpha" EXACT []
synonym: "CEBP" RELATED Gene-based []
synonym: "CEBPA" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P49715
[Term]
id: PR:000006169
@@ -10574,6 +10575,7 @@ synonym: "terminal addition enzyme" EXACT []
synonym: "terminal deoxynucleotidyltransferase" EXACT []
synonym: "terminal transferase" EXACT []
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P04053
[Term]
id: PR:000007431
@@ -10588,6 +10590,7 @@ synonym: "FcERI" RELATED []
synonym: "IgE Fc receptor subunit alpha" EXACT []
xref: IUPHARobj:2933
is_a: PR:000001355 ! immunoglobulin gamma Fc receptor II/III/IV
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P12319
[Term]
id: PR:000007597
@@ -10602,6 +10605,7 @@ synonym: "G0S7" RELATED Gene-based []
synonym: "proto-oncogene protein c-fos" EXACT []
synonym: "transcription factor AP-1 subunit c-Fos" EXACT []
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P01100
[Term]
id: PR:000007857
@@ -10618,6 +10622,7 @@ synonym: "GF-1" RELATED []
synonym: "GF1" RELATED Gene-based []
synonym: "NF-E1 DNA-binding protein" EXACT []
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P15976
[Term]
id: PR:000007858
@@ -10628,6 +10633,7 @@ comment: Category=gene. Requested by=CL.
synonym: "GATA-binding protein 2" EXACT []
synonym: "GATA2" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P23769
[Term]
id: PR:000009143
@@ -10641,6 +10647,7 @@ synonym: "ITGB7" EXACT PRO-short-label [PRO:DNx]
synonym: "M290 IEL antigen" EXACT []
xref: IUPHARobj:2461
is_a: PR:000001861 ! integrin beta
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P26010
[Term]
id: PR:000011178
@@ -10657,6 +10664,7 @@ synonym: "NFKB2" EXACT PRO-short-label [PRO:DNx]
synonym: "nuclear factor of kappa light polypeptide gene enhancer in B-cells 2" EXACT []
synonym: "oncogene Lyt-10" EXACT []
is_a: PR:000001753 ! transcription factor NF-kappa-B subunit
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:Q00653
[Term]
id: PR:000014841
@@ -10670,6 +10678,7 @@ synonym: "SHH" EXACT PRO-short-label [PRO:DNx]
synonym: "Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains" EXACT []
synonym: "ShhNC" EXACT []
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:Q15465
[Term]
id: PR:000016043
@@ -10687,6 +10696,7 @@ synonym: "TAL-1" EXACT []
synonym: "TAL1" EXACT PRO-short-label [PRO:DNx]
synonym: "TCL5" RELATED Gene-based []
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:P17542
[Term]
id: PR:000016401
@@ -10702,6 +10712,7 @@ synonym: "p24gamma1" EXACT []
synonym: "putative T1/ST2 receptor-binding protein" EXACT []
synonym: "TMED1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000000001 ! protein
+property_value: https://w3id.org/semapv/vocab/crossSpeciesExactMatch PR:Q13445
[Term]
id: PR:000025796
@@ -11268,7 +11279,10 @@ relationship: only_in_taxon NCBITaxon:6072 ! Eumetazoa
relationship: part_of UBERON:0000068 ! embryo stage
relationship: preceded_by UBERON:0000109 ! gastrula stage
relationship: simultaneous_with GO:0001841 ! neural tube formation
+property_value: RO:0002174 NCBITaxon:7955
+property_value: seeAlso "https://github.com/obophenotype/developmental-stage-ontologies/issues/84" xsd:anyURI
property_value: seeAlso "https://github.com/obophenotype/uberon/issues/343" xsd:anyURI
+property_value: UBPROP:0000008 "In zebrafish, the times of neurulation and segmentation overlap so extensively there is no distinct neurula period of development, such as occurs largely before segmentation in amphibian embryos." xsd:string
[Term]
id: UBERON:0000111
@@ -11287,8 +11301,8 @@ is_a: BFO:0000003 ! occurrent
is_a: UBERON:0000105 ! life cycle stage
relationship: only_in_taxon NCBITaxon:6072 ! Eumetazoa
relationship: part_of UBERON:0000068 ! embryo stage
-relationship: preceded_by UBERON:0000110 ! neurula stage
relationship: simultaneous_with GO:0048513 ! animal organ development
+property_value: seeAlso "https://github.com/obophenotype/developmental-stage-ontologies/issues/84" xsd:anyURI
property_value: seeAlso "https://github.com/obophenotype/uberon/issues/533" xsd:anyURI
[Term]
@@ -11360,7 +11374,6 @@ xref: Wikipedia:Mouth
xref: XAO:0003029
xref: ZFA:0000547
xref: ZFA:0000590
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0004921 {notes="the mouth contains structures such as jaw skeleton that may not strictly be considered tract parts"} ! subdivision of digestive tract
intersection_of: UBERON:0004921 ! subdivision of digestive tract
intersection_of: proximalmost_part_of UBERON:0001555 ! digestive tract
@@ -11412,7 +11425,6 @@ xref: VHOG:0000224
xref: Wikipedia:Blood
xref: XAO:0000124
xref: ZFA:0000007
-is_a: CARO:0000000 ! anatomical entity
is_a: PR:000050567 ! protein-containing material entity
is_a: UBERON:0000179 ! haemolymphatic fluid
relationship: has_part CL:0000232 {source="CL:tm"} ! erythrocyte
@@ -11458,7 +11470,6 @@ xref: GAID:1294
xref: MESH:D036703
xref: OGEM:000006
xref: Wikipedia:Blastula
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000922 ! embryo
intersection_of: UBERON:0000468 ! multicellular organism
intersection_of: existence_starts_and_ends_during UBERON:0000108 ! blastula stage
@@ -11495,7 +11506,6 @@ xref: MAT:0000025
xref: MIAA:0000025
xref: VSAO:0000033
xref: XAO:0004042
-is_a: CARO:0000006 ! material anatomical entity
is_a: UBERON:0011216 ! organ system subdivision
intersection_of: UBERON:0011216 ! organ system subdivision
intersection_of: composed_primarily_of UBERON:0001015 ! musculature
@@ -12000,7 +12010,6 @@ xref: FMA:259209
xref: MA:0000022
xref: SCTID:302551006
xref: Wikipedia:Thorax
-is_a: CARO:0010000 ! multicellular anatomical structure
is_a: UBERON:0009569 {source="FMA"} ! subdivision of trunk
is_a: UBERON:0011676 ! subdivision of organism along main body axis
intersection_of: UBERON:0011676 ! subdivision of organism along main body axis
@@ -12536,7 +12545,6 @@ xref: VSAO:0005038
xref: WBbt:0005737
xref: Wikipedia:Muscular_system
xref: ZFA:0000548
-is_a: CARO:0000006 ! material anatomical entity
is_a: UBERON:0011216 ! organ system subdivision
relationship: composed_primarily_of UBERON:0001630 ! muscle organ
relationship: part_of UBERON:0000383 ! musculature of body
@@ -12584,7 +12592,6 @@ xref: WBbt:0005735
xref: Wikipedia:Nervous_system
xref: XAO:0000177
xref: ZFA:0000396
-is_a: CARO:0000006 ! material anatomical entity
is_a: UBERON:0000467 ! anatomical system
disjoint_from: UBERON:0001434 ! skeletal system
disjoint_from: UBERON:0002204 ! musculoskeletal system
@@ -12891,7 +12898,6 @@ xref: UMLS:C0017189 {source="ncithesaurus:Gastrointestinal_Tract"}
xref: VHOG:0000309
xref: WBbt:0005743
xref: ZFA:0000112
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000025 ! tube
relationship: connects UBERON:0000165 ! mouth
relationship: immediate_transformation_of UBERON:0007026 {source="NCBIBook:NBK10107"} ! presumptive gut
@@ -13012,7 +13018,6 @@ xref: VHOG:0001250
xref: Wikipedia:Blood_vessel
xref: XAO:0001011
xref: ZFA:0005314
-is_a: CARO:0000000 ! anatomical entity
is_a: PR:000050567 ! protein-containing material entity
is_a: UBERON:0000055 ! vessel
relationship: capable_of_part_of GO:0008015 ! blood circulation
@@ -13183,7 +13188,6 @@ xref: VHOG:0000317
xref: VSAO:0000093
xref: XAO:0003073
xref: ZFA:0000317
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0010912 ! subdivision of skeleton
relationship: develops_from UBERON:0003089 ! sclerotome
relationship: part_of UBERON:0005944 ! axial skeleton plus cranial skeleton
@@ -13271,7 +13275,6 @@ xref: VHOG:0001275
xref: VSAO:0000031
xref: Wikipedia:Musculoskeletal_system
xref: XAO:0000168
-is_a: CARO:0000006 ! material anatomical entity
is_a: UBERON:0000467 ! anatomical system
disjoint_from: UBERON:0002390 ! hematopoietic system
disjoint_from: UBERON:0002405 ! immune system
@@ -13347,7 +13350,6 @@ xref: SCTID:361348008
xref: TAO:0001438
xref: UMLS:C0333343 {source="ncithesaurus:Cavity"}
xref: ZFA:0001438
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0002553 ! anatomical cavity
relationship: luminal_space_of UBERON:0011997 ! coelom
relationship: transformation_of UBERON:0003886 {evidence="definitional"} ! future coelemic cavity lumen
@@ -13445,7 +13447,6 @@ xref: VHOG:0000191
xref: Wikipedia:Somite
xref: XAO:0000058
xref: ZFA:0000155
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0005423 ! developing anatomical structure
is_a: UBERON:0007503 {source="EHDAA2"} ! epithelial vesicle
relationship: develops_from UBERON:0003059 {source="ZFA"} ! presomitic mesoderm
@@ -13707,7 +13708,6 @@ xref: VHOG:0001624
xref: Wikipedia:Haematopoiesis
xref: XAO:0000122
xref: ZFA:0005023
-is_a: CARO:0000006 ! material anatomical entity
is_a: UBERON:0000467 ! anatomical system
is_a: UBERON:0004120 ! mesoderm-derived structure
disjoint_from: UBERON:0002405 ! immune system
@@ -13907,7 +13907,6 @@ xref: VHOG:0000107
xref: Wikipedia:Chordamesoderm
xref: XAO:0000205
xref: ZFA:0001204
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0002050 ! embryonic structure
relationship: develops_from UBERON:0000926 ! mesoderm
relationship: only_in_taxon NCBITaxon:7711 ! Chordata
@@ -13943,7 +13942,6 @@ xref: VHOG:0000068
xref: Wikipedia:Neural_plate
xref: XAO:0000249
xref: ZFA:0000132
-is_a: CARO:0000006 ! material anatomical entity
is_a: UBERON:0005291 ! embryonic tissue
is_a: UBERON:0010371 ! ecto-epithelium
is_a: UBERON:0016879 ! future central nervous system
@@ -14043,7 +14041,6 @@ xref: TAO:0000028
xref: UMLS:C1514450 {source="ncithesaurus:Primordium_of_the_Heart"}
xref: XAO:0000336
xref: ZFA:0000028
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0001048 {source="Obol"} ! primordium
relationship: develops_from UBERON:0003081 {source="ZFA"} ! lateral plate mesoderm
relationship: develops_from UBERON:0004140 ! primary heart field
@@ -14155,7 +14152,6 @@ subset: grouping_class
subset: non_informative
synonym: "body cavity precursor" RELATED []
synonym: "future coelomic cavity lumen" EXACT []
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000464 ! anatomical space
intersection_of: UBERON:0000464 ! anatomical space
intersection_of: has_potential_to_develop_into UBERON:0002323 ! coelemic cavity lumen
@@ -14177,7 +14173,6 @@ xref: NCIT:C34195
xref: UMLS:C1512940 {source="ncithesaurus:Intraembryonic_Coelom"}
xref: VHOG:0000316
xref: Wikipedia:Intraembryonic_coelom
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0002050 ! embryonic structure
relationship: develops_from UBERON:0003081 {source="Wikipedia"} ! lateral plate mesoderm
relationship: part_of UBERON:0011997 ! coelom
@@ -14234,7 +14229,6 @@ namespace: uberon
def: "An anatomical structure that develops (entirely or partially) from the mesoderm." [https://orcid.org/0000-0002-6601-2165]
subset: grouping_class
synonym: "mesodermal derivative" EXACT [FBbt:00025998]
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000061 ! anatomical structure
intersection_of: UBERON:0000061 ! anatomical structure
intersection_of: develops_from UBERON:0000926 ! mesoderm
@@ -14248,7 +14242,6 @@ namespace: uberon
def: "An anatomical structure that develops (entirely or partially) from the ectoderm." [https://orcid.org/0000-0002-6601-2165]
subset: grouping_class
synonym: "ectodermal deriviative" EXACT [FBbt:00025990]
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000061 ! anatomical structure
intersection_of: UBERON:0000061 ! anatomical structure
intersection_of: develops_from UBERON:0000924 ! ectoderm
@@ -14268,7 +14261,6 @@ synonym: "myocardial plate" EXACT [EHDAA2:0000215]
xref: EHDAA2:0000215
xref: EMAPA:16106
xref: VHOG:0000975
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0002050 ! embryonic structure
relationship: develops_from UBERON:0003084 ! heart primordium
property_value: editor_note "TODO - check plate vs rudiment vs primordium vs endocardial tube. See XAO" xsd:string
@@ -14414,7 +14406,6 @@ xref: WikipediaCategory:Cardiovascular_system
xref: XAO:0000100
xref: XAO:0001010
xref: ZFA:0000010
-is_a: CARO:0000006 ! material anatomical entity
is_a: PR:000050567 ! protein-containing material entity
is_a: UBERON:0000467 ! anatomical system
intersection_of: UBERON:0000467 ! anatomical system
@@ -14440,7 +14431,6 @@ synonym: "blood vessels" RELATED [TAO:0001079]
synonym: "set of blood vessels" EXACT []
xref: TAO:0001079
xref: ZFA:0001079
-is_a: CARO:0000000 ! anatomical entity
is_a: PR:000050567 ! protein-containing material entity
is_a: UBERON:0002049 ! vasculature
intersection_of: UBERON:0002049 ! vasculature
@@ -14482,7 +14472,6 @@ xref: EMAPA:36040
xref: NCIT:C34131
xref: UMLS:C1516779 {source="ncithesaurus:Conceptus"}
xref: Wikipedia:Conceptus
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000061 ! anatomical structure
relationship: develops_from CL:0000365 ! animal zygote
relationship: existence_ends_with UBERON:0000068 ! embryo stage
@@ -14520,7 +14509,6 @@ xref: UMLS:C0017199 {source="ncithesaurus:Gastrula"}
xref: UMLS:C1284022 {source="ncithesaurus:Trilaminar_Embryonic_Disc"}
xref: Wikipedia:Gastrula
xref: Wikipedia:Trilaminar_blastocyst
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000922 ! embryo
intersection_of: UBERON:0000468 ! multicellular organism
intersection_of: existence_starts_and_ends_during UBERON:0000109 ! gastrula stage
@@ -14540,7 +14528,6 @@ xref: SCTID:309311006
xref: VSAO:0000015
xref: XAO:0004038
xref: ZFA:0005619
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0002384 {source="VSAO"} ! connective tissue
relationship: develops_from CL:0007001 {date_retrieved="2012-08-14", external_class="VSAO:0000015", source="VSAO"} ! skeletogenic cell
relationship: part_of UBERON:0004765 ! skeletal element
@@ -14759,7 +14746,6 @@ synonym: "muscle element" RELATED []
synonym: "musculus" EXACT [FMA:30316]
xref: EMAPA:32715
xref: FMA:30316
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000061 ! anatomical structure
relationship: has_part CL:0000187 ! muscle cell
relationship: only_in_taxon NCBITaxon:6072 ! Eumetazoa
@@ -14969,7 +14955,6 @@ xref: UMLS:C0222645 {source="ncithesaurus:Axial_Skeleton"}
xref: VSAO:0000056
xref: Wikipedia:Axial_skeleton
xref: XAO:0004011
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0010912 ! subdivision of skeleton
relationship: contributes_to_morphology_of UBERON:0001434 ! skeletal system
relationship: develops_from UBERON:0003089 ! sclerotome
@@ -15015,7 +15000,6 @@ xref: FMA:293135
xref: NCIT:C34232
xref: UMLS:C1518430 {source="ncithesaurus:Notochordal_Process"}
xref: VHOG:0001213
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0005423 ! developing anatomical structure
relationship: develops_from UBERON:0000924 {source="EHDAA2"} ! ectoderm
relationship: only_in_taxon NCBITaxon:7711 ! Chordata
@@ -15103,7 +15087,6 @@ synonym: "presumptive structures" EXACT [ZFA:0001116]
xref: AAO:0000479
xref: TAO:0001116
xref: ZFA:0001116
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0002050 ! embryonic structure
intersection_of: UBERON:0005423 ! developing anatomical structure
intersection_of: has_potential_to_develop_into UBERON:0000061 ! anatomical structure
@@ -15174,7 +15157,6 @@ subset: efo_slim
xref: EFO:0003709
xref: TAO:0005077
xref: ZFA:0005077
-is_a: CARO:0000006 ! material anatomical entity
is_a: PR:000050567 ! protein-containing material entity
is_a: UBERON:0005423 ! developing anatomical structure
relationship: has_part CL:0000115 ! endothelial cell
@@ -15218,7 +15200,6 @@ xref: FMA:293143
xref: SCTID:360387000
xref: VHOG:0001641
xref: XAO:0000235
-is_a: CARO:0000006 ! material anatomical entity
is_a: UBERON:0005291 ! embryonic tissue
relationship: developmentally_induced_by UBERON:0009881 ! anterior lateral plate mesoderm
relationship: develops_from UBERON:0004872 ! splanchnic layer of lateral plate mesoderm
@@ -15378,7 +15359,6 @@ namespace: uberon
def: "Mesenchyme with little extracellular matrix." [AEO:JB]
xref: AEO:0000146
xref: EHDAA2:0003146
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0003104 {source="AEO"} ! mesenchyme
relationship: has_part CL:0000057 {source="AEO"} ! fibroblast
@@ -15467,7 +15447,6 @@ def: "Sum total of mesenchyme in the embryo." [https://github.com/obophenotype/h
xref: EHDAA2:0001113
xref: EHDAA:177
xref: EMAPA:16097
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000477 ! anatomical cluster
relationship: composed_primarily_of UBERON:0003104 ! mesenchyme
relationship: has_developmental_contribution_from UBERON:0000926 {source="EHDAA2"} ! mesoderm
@@ -15551,7 +15530,6 @@ synonym: "thrombus" EXACT [BTO:0000102]
xref: BTO:0000102
xref: galen:BloodClot
xref: Wikipedia:Thrombus
-is_a: CARO:0000000 ! anatomical entity
is_a: PR:000050567 ! protein-containing material entity
is_a: UBERON:0000463 ! organism substance
intersection_of: UBERON:0000463 ! organism substance
@@ -15569,7 +15547,6 @@ name: structure with developmental contribution from neural crest
namespace: uberon
def: "An anatomical structure that has some part that develops from the neural crest." [https://orcid.org/0000-0002-6601-2165]
subset: grouping_class
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0000061 ! anatomical structure
intersection_of: UBERON:0000061 ! anatomical structure
intersection_of: has_developmental_contribution_from UBERON:0002342 ! neural crest
@@ -15580,7 +15557,6 @@ property_value: IAO:0000232 "Grouping term for query purposes" xsd:string
id: UBERON:0010316
name: germ layer / neural crest
namespace: uberon
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0002050 ! embryonic structure
is_a: UBERON:0005291 ! embryonic tissue
relationship: develops_from UBERON:0002532 ! epiblast (generic)
@@ -15620,7 +15596,6 @@ name: axial skeletal system
namespace: uberon
def: "Subdivision of the skeletal system which consists of the axial skeleton plus associated joints." [https://orcid.org/0000-0002-6601-2165]
xref: FMA:7483
-is_a: CARO:0000006 ! material anatomical entity
is_a: UBERON:0000075 {source="FMA"} ! subdivision of skeletal system
relationship: has_part UBERON:0000982 ! skeletal joint
relationship: has_part UBERON:0005944 ! axial skeleton plus cranial skeleton
@@ -15634,7 +15609,6 @@ def: "Subdivision of the skeletal system which consists of the postcranial axial
synonym: "axial skeletal system" BROAD [https://github.com/obophenotype/uberon/wiki/The-axial-skeleton]
synonym: "post-cranial axial skeletal system" EXACT []
xref: FMA:302077
-is_a: CARO:0000006 ! material anatomical entity
is_a: UBERON:0000075 {source="FMA"} ! subdivision of skeletal system
relationship: develops_from UBERON:0003089 {source="cjm"} ! sclerotome
property_value: seeAlso "http://purl.obolibrary.org/obo/uberon/docs/The-axial-skeleton" xsd:anyURI
@@ -15822,7 +15796,6 @@ def: "A portion of tissue that will develop into vasculature." [ZFA:0005076, ZFA
xref: EFO:0003708
xref: TAO:0005076
xref: ZFA:0005076
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0001048 ! primordium
intersection_of: UBERON:0001048 ! primordium
intersection_of: has_potential_to_develop_into UBERON:0002049 ! vasculature
@@ -15989,7 +15962,6 @@ def: "The primordial mouth region of the developing head." [MP:0003119]
synonym: "primitive mouth" EXACT [FMA:293105]
synonym: "primordial mouth" EXACT []
xref: FMA:293105
-is_a: CARO:0000000 ! anatomical entity
is_a: UBERON:0013522 ! subdivision of tube
relationship: has_part UBERON:0000925 ! endoderm
relationship: has_part UBERON:0000930 ! stomodeum
@@ -16019,6 +15991,16 @@ id: CL:4030046
name: lacks_plasma_membrane_part
expand_expression_to: "http://purl.obolibrary.org/obo/BFO_0000051 exactly 0 (http://purl.obolibrary.org/obo/GO_0005886 and http://purl.obolibrary.org/obo/BFO_0000051 some ?Y)" []
+[Typedef]
+id: IAO:0000136
+name: is about
+def: "A (currently) primitive relation that relates an information artifact to an entity." []
+property_value: editor_note "7/6/2009 Alan Ruttenberg. Following discussion with Jonathan Rees, and introduction of \"mentions\" relation. Weaken the is_about relationship to be primitive. \n\nWe will try to build it back up by elaborating the various subproperties that are more precisely defined.\n\nSome currently missing phenomena that should be considered \"about\" are predications - \"The only person who knows the answer is sitting beside me\" , Allegory, Satire, and other literary forms that can be topical without explicitly mentioning the topic." xsd:string
+property_value: IAO:0000112 "This document is about information artifacts and their representations" xsd:string
+property_value: IAO:0000114 IAO:0000125
+property_value: IAO:0000117 "person:Alan Ruttenberg" xsd:string
+property_value: IAO:0000119 "Smith, Ceusters, Ruttenberg, 2000 years of philosophy" xsd:string
+
[Typedef]
id: RO:0000052
name: characteristic of
@@ -16176,7 +16158,7 @@ def: "A relationship that holds between a GO molecular function and a component
comment: By convention GO molecular functions are classified by their effector function and internal regulatory functions are treated as components. So, for example calmodulin has a protein binding activity that has positive regulatory component activity calcium binding activity. Receptor tyrosine kinase activity is a tyrosine kinase activity that has positive regulatory component 'ligand binding'.
is_a: has_regulatory_component_activity ! has regulatory component activity
is_a: positively_regulated_by ! positively regulated by
-created_by: dos
+created_by: https://orcid.org/0000-0002-7073-9172
creation_date: 2017-05-24T09:31:17Z
[Typedef]
@@ -16184,7 +16166,7 @@ id: RO:0002017
name: has component activity
comment: A 'has component activity' B if A is A and B are molecular functions (GO_0003674) and A has_component B.
is_a: RO:0002018 ! has component process
-created_by: dos
+created_by: https://orcid.org/0000-0002-7073-9172
creation_date: 2017-05-24T09:44:33Z
[Typedef]
@@ -16194,7 +16176,7 @@ def: "w 'has process component' p if p and w are processes, w 'has part' p and
domain: BFO:0000015 ! process
range: BFO:0000015 ! process
is_a: has_component ! has component
-created_by: dos
+created_by: https://orcid.org/0000-0002-7073-9172
creation_date: 2017-05-24T09:49:21Z
[Typedef]
@@ -16202,44 +16184,44 @@ id: RO:0002021
name: occurs across
def: "A relationship between a process and a barrier, where the process occurs in a region spanning the barrier. For cellular processes the barrier is typically a membrane. Examples include transport across a membrane and membrane depolarization." []
is_a: RO:0002479 ! has part that occurs in
-created_by: dos
+created_by: https://orcid.org/0000-0002-7073-9172
creation_date: 2017-07-20T17:19:37Z
[Typedef]
id: RO:0002022
name: directly regulated by
-comment: Process(P2) is directly regulated by process(P1) iff: P1 regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding regulates the kinase activity (P2) of protein B then P1 directly regulates P2. {xref="GOC:dos"}
+comment: Process(P2) is directly regulated by process(P1) iff: P1 regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding regulates the kinase activity (P2) of protein B then P1 directly regulates P2. {xref="https://orcid.org/0000-0002-7073-9172"}
is_a: regulated_by ! regulated by
inverse_of: directly_regulates ! directly regulates
-created_by: dos
+created_by: https://orcid.org/0000-0002-7073-9172
creation_date: 2017-09-17T13:52:24Z
[Typedef]
id: RO:0002023
name: directly negatively regulated by
-def: "Process(P2) is directly negatively regulated by process(P1) iff: P1 negatively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding negatively regulates the kinase activity (P2) of protein B then P2 directly negatively regulated by P1." [GOC:dos]
+def: "Process(P2) is directly negatively regulated by process(P1) iff: P1 negatively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding negatively regulates the kinase activity (P2) of protein B then P2 directly negatively regulated by P1." [https://orcid.org/0000-0002-7073-9172]
is_a: RO:0002022 ! directly regulated by
inverse_of: directly_negatively_regulates ! directly negatively regulates
-created_by: dos
+created_by: https://orcid.org/0000-0002-7073-9172
creation_date: 2017-09-17T13:52:38Z
[Typedef]
id: RO:0002024
name: directly positively regulated by
-def: "Process(P2) is directly postively regulated by process(P1) iff: P1 positively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding positively regulates the kinase activity (P2) of protein B then P2 is directly postively regulated by P1." [GOC:dos]
+def: "Process(P2) is directly postively regulated by process(P1) iff: P1 positively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding positively regulates the kinase activity (P2) of protein B then P2 is directly postively regulated by P1." [https://orcid.org/0000-0002-7073-9172]
is_a: RO:0002022 ! directly regulated by
inverse_of: directly_positively_regulates ! directly positively regulates
-created_by: dos
+created_by: https://orcid.org/0000-0002-7073-9172
creation_date: 2017-09-17T13:52:47Z
[Typedef]
id: RO:0002025
name: has effector activity
-def: "A 'has effector activity' B if A and B are GO molecular functions (GO_0003674), A 'has component activity' B and B is the effector (output function) of B. Each compound function has only one effector activity." [GOC:dos]
+def: "A 'has effector activity' B if A and B are GO molecular functions (GO_0003674), A 'has component activity' B and B is the effector (output function) of B. Each compound function has only one effector activity." [https://orcid.org/0000-0002-7073-9172]
comment: This relation is designed for constructing compound molecular functions, typically in combination with one or more regulatory component activity relations.
is_functional: true
is_a: RO:0002017 ! has component activity
-created_by: dos
+created_by: https://orcid.org/0000-0002-7073-9172
creation_date: 2017-09-22T14:14:36Z
[Typedef]
@@ -16264,14 +16246,14 @@ is_a: RO:0002222 ! temporally related to
id: RO:0002100
name: has soma location
namespace: fly_anatomy.ontology
-def: "Relation between a neuron and an anatomical structure that its soma is part of." []
+def: "Relation between a neuron and a material anatomical entity that its soma is part of." []
def: "Relation between a neuron and an anatomical structure that its soma is part of." [https://orcid.org/0000-0002-7073-9172]
xref: RO:0002100
property_value: IAO:0000114 IAO:0000125
property_value: IAO:0000117 https://orcid.org/0000-0002-7073-9172
property_value: RO:0001900 RO:0001901
domain: CL:0000540 ! neuron
-range: CARO:0000003 ! connected anatomical structure
+range: UBERON:0000465 ! material anatomical entity
is_a: overlaps ! overlaps
transitive_over: part_of ! part_of
expand_expression_to: "BFO_0000051 some (\n GO_0043025 and BFO_0000050 some ?Y)" []
@@ -16319,8 +16301,8 @@ property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000117 https://orcid.org/0000-0003-1617-8244
property_value: IAO:0000119 http://www.ncbi.nlm.nih.gov/pubmed/19243617
property_value: RO:0001900 RO:0001901
-domain: CARO:0000006 ! material anatomical entity
-range: CARO:0000006 ! material anatomical entity
+domain: UBERON:0000465 ! material anatomical entity
+range: UBERON:0000465 ! material anatomical entity
is_a: has_part ! has part
expand_expression_to: "BFO_0000051 some (GO_0005886 and BFO_0000051 some ?Y)" []
@@ -16445,7 +16427,7 @@ property_value: IAO:0000112 "'neural crest cell' SubClassOf expresses some 'Wnt
property_value: IAO:0000114 IAO:0000125
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
domain: BFO:0000002 ! continuant
-range: CARO:0000006 ! material anatomical entity
+range: UBERON:0000465 ! material anatomical entity
is_a: RO:0002330 ! genomically related to
inverse_of: RO:0002292 ! expresses
transitive_over: part_of ! part_of
@@ -16523,7 +16505,7 @@ def: "c acts upstream of or within p if c is enables f, and f is causally upstre
subset: http://purl.obolibrary.org/obo/valid_for_go_gp2term
synonym: "affects" RELATED []
property_value: IAO:0000112 "A gene product that has some activity, where that activity may be a part of a pathway or upstream of the pathway." xsd:string
-property_value: seeAlso http://wiki.geneontology.org/index.php/Acts_upstream_of_or_within
+property_value: seeAlso "https://wiki.geneontology.org/Acts_upstream_of_or_within" xsd:anyURI
holds_over_chain: RO:0002327 causally_upstream_of_or_within
is_a: RO:0002500 ! causal agent in process
@@ -16547,7 +16529,7 @@ is_a: RO:0002286 ! developmentally succeeded by
[Typedef]
id: RO:0002292
name: expresses
-def: "Inverse of 'expressed in'" []
+def: "y expresses x if and only if there is a gene expression process (GO:0010467) that occurs in y, and one of the following holds: (i) x is a gene, and x is transcribed into a transcript as part of the gene expression process (ii) x is a transcript, and x was transcribed from a gene as part of the gene expression process (iii) x is a mature gene product (protein or RNA), and x was translated or otherwise processed from a transcript that was transcribed as part of the gene expression process." []
property_value: IAO:0000114 IAO:0000125
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
is_a: RO:0002330 ! genomically related to
@@ -16601,6 +16583,7 @@ property_value: IAO:0000118 "has" xsd:string
property_value: IAO:0000118 "is catalyzing" xsd:string
property_value: IAO:0000118 "is executing" xsd:string
property_value: IAO:0000232 "This relation differs from the parent relation 'capable of' in that the parent is weaker and only expresses a capability that may not be actually realized, whereas this relation is always realized." xsd:string
+property_value: seeAlso "https://wiki.geneontology.org/Enables" xsd:anyURI
is_a: capable_of ! capable of
inverse_of: RO:0002333 ! enabled by
transitive_over: has_part ! has part
@@ -16631,7 +16614,7 @@ def: "c involved_in p if and only if c enables some process p', and p' is part o
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000118 "actively involved in" xsd:string
property_value: IAO:0000118 "enables part of" xsd:string
-property_value: seeAlso Involved:in
+property_value: seeAlso "https://wiki.geneontology.org/Involved_in" xsd:anyURI
holds_over_chain: RO:0002327 part_of
is_a: participates_in ! participates in
is_a: RO:0002431 ! involved in or involved in regulation of
@@ -16643,6 +16626,7 @@ name: enabled by
def: "inverse of enables" []
subset: http://purl.obolibrary.org/obo/valid_for_gocam
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
+property_value: seeAlso "https://wiki.geneontology.org/Enabled_by" xsd:anyURI
is_a: functionally_related_to ! functionally related to
is_a: has_participant ! has participant
@@ -16710,8 +16694,8 @@ name: has developmental potential involving
def: "x has developmental potential involving y iff x is capable of a developmental process with output y. y may be the successor of x, or may be a different structure in the vicinity (as for example in the case of developmental induction)." []
property_value: IAO:0000114 IAO:0000428
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
-domain: CARO:0000000 ! anatomical entity
-range: CARO:0000000 ! anatomical entity
+domain: UBERON:0001062 ! anatomical entity
+range: UBERON:0001062 ! anatomical entity
is_a: RO:0002324 ! developmentally related to
[Typedef]
@@ -16737,6 +16721,7 @@ def: "p indirectly positively regulates q iff p is indirectly causally upstream
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000118 "indirectly activates" xsd:string
property_value: RO:0002579 RO:0002213
+property_value: seeAlso "https://wiki.geneontology.org/Indirectly_positively_regulates" xsd:anyURI
holds_over_chain: directly_positively_regulates directly_positively_regulates
holds_over_chain: directly_positively_regulates RO:0002407
holds_over_chain: RO:0002409 RO:0002409
@@ -16752,6 +16737,7 @@ def: "p indirectly negatively regulates q iff p is indirectly causally upstream
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000118 "indirectly inhibits" xsd:string
property_value: RO:0002579 RO:0002212
+property_value: seeAlso "https://wiki.geneontology.org/Indirectly_negatively_regulates" xsd:anyURI
holds_over_chain: directly_negatively_regulates directly_negatively_regulates
holds_over_chain: directly_negatively_regulates RO:0002409
is_transitive: true
@@ -16811,11 +16797,12 @@ is_a: RO:0002500 ! causal agent in process
[Typedef]
id: RO:0002432
name: is active in
-def: "c executes activity in d if and only if c enables p and p occurs_in d. Assuming no action at a distance by gene products, if a gene product enables (is capable of) a process that occurs in some structure, it must have at least some part in that structure." [GOC:cjm, GOC:dos]
+def: "c executes activity in d if and only if c enables p and p occurs_in d. Assuming no action at a distance by gene products, if a gene product enables (is capable of) a process that occurs in some structure, it must have at least some part in that structure." [https://orcid.org/0000-0002-6601-2165, https://orcid.org/0000-0002-7073-9172]
synonym: "enables activity in" EXACT []
property_value: IAO:0000112 "A protein that enables activity in a cytosol." xsd:string
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000118 "executes activity in" xsd:string
+property_value: seeAlso "https://wiki.geneontology.org/Is_active_in" xsd:anyURI
holds_over_chain: RO:0002327 occurs_in {http://purl.obolibrary.org/obo/RO_0002581="true"}
is_a: functionally_related_to ! functionally related to
is_a: overlaps ! overlaps
@@ -17022,8 +17009,8 @@ name: biomechanically related to
def: "A relation that holds between elements of a musculoskeletal system or its analogs." []
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000232 "Do not use this relation directly. It is ended as a grouping for a diverse set of relations, all involving the biomechanical processes." xsd:string
-domain: CARO:0000003 ! connected anatomical structure
-range: CARO:0000003 ! connected anatomical structure
+domain: UBERON:0000061 ! anatomical structure
+range: UBERON:0000061 ! anatomical structure
is_a: functionally_related_to ! functionally related to
[Typedef]
@@ -17079,6 +17066,12 @@ property_value: IAO:0000119 http://purl.obolibrary.org/obo/ro/docs/causal-relati
holds_over_chain: capable_of positively_regulates
is_a: RO:0002596 ! capable of regulating
+[Typedef]
+id: RO:0002610
+name: correlated with
+def: "A relationship that holds between two entities, where the entities exhibit a statistical dependence relationship. The entities may be statistical variables, or they may be other kinds of entities such as diseases, chemical entities or processes." []
+property_value: IAO:0000232 "Groups both positive and negative correlation" xsd:string
+
[Typedef]
id: RO:0004031
name: enables subfunction
@@ -17093,7 +17086,7 @@ id: RO:0004032
name: acts upstream of or within, positive effect
subset: http://purl.obolibrary.org/obo/valid_for_go_gp2term
property_value: RO:0004049 RO:0002264
-property_value: seeAlso http://wiki.geneontology.org/index.php/Acts_upstream_of_or_within,_positive_effect
+property_value: seeAlso "https://wiki.geneontology.org/Acts_upstream_of_or_within,_positive_effect" xsd:anyURI
holds_over_chain: RO:0002327 RO:0004047
is_a: RO:0002264 ! acts upstream of or within
created_by: https://orcid.org/0000-0002-6601-2165
@@ -17104,6 +17097,7 @@ id: RO:0004033
name: acts upstream of or within, negative effect
subset: http://purl.obolibrary.org/obo/valid_for_go_gp2term
property_value: RO:0004050 RO:0002264
+property_value: seeAlso "https://wiki.geneontology.org/Acts_upstream_of_or_within,_negative_effect" xsd:anyURI
holds_over_chain: RO:0002327 RO:0004046
is_a: RO:0002264 ! acts upstream of or within
created_by: https://orcid.org/0000-0002-6601-2165
@@ -17115,7 +17109,7 @@ name: acts upstream of, positive effect
def: "c 'acts upstream of, positive effect' p if c is enables f, and f is causally upstream of p, and the direction of f is positive" []
subset: http://purl.obolibrary.org/obo/valid_for_go_gp2term
property_value: RO:0004049 RO:0002263
-property_value: seeAlso http://wiki.geneontology.org/index.php/Acts_upstream_of,_positive_effect
+property_value: seeAlso "https://wiki.geneontology.org/Acts_upstream_of,_positive_effect" xsd:anyURI
holds_over_chain: RO:0002327 causally_upstream_of,_positive_effect
is_a: RO:0002263 ! acts upstream of
is_a: RO:0004032 ! acts upstream of or within, positive effect
@@ -17128,7 +17122,7 @@ name: acts upstream of, negative effect
def: "c 'acts upstream of, negative effect' p if c is enables f, and f is causally upstream of p, and the direction of f is negative" []
subset: http://purl.obolibrary.org/obo/valid_for_go_gp2term
property_value: RO:0004050 RO:0002263
-property_value: seeAlso http://wiki.geneontology.org/index.php/Acts_upstream_of,_negative_effect
+property_value: seeAlso "https://wiki.geneontology.org/Acts_upstream_of,_negative_effect" xsd:anyURI
holds_over_chain: RO:0002327 causally_upstream_of,_negative_effect
is_a: RO:0002263 ! acts upstream of
is_a: RO:0004033 ! acts upstream of or within, negative effect
@@ -17139,6 +17133,7 @@ creation_date: 2018-01-26T23:53:22Z
id: RO:0004046
name: causally upstream of or within, negative effect
property_value: RO:0004050 RO:0002418
+property_value: seeAlso "https://wiki.geneontology.org/Causally_upstream_of_or_within,_negative_effect" xsd:anyURI
is_a: causally_upstream_of_or_within ! causally upstream of or within
created_by: https://orcid.org/0000-0002-6601-2165
creation_date: 2018-03-13T23:55:05Z
@@ -17147,6 +17142,7 @@ creation_date: 2018-03-13T23:55:05Z
id: RO:0004047
name: causally upstream of or within, positive effect
property_value: RO:0004049 RO:0002418
+property_value: seeAlso https://wiki.geneontology.org/Causally_upstream_of_or_within,_positive_effect
is_a: causally_upstream_of_or_within ! causally upstream of or within
created_by: https://orcid.org/0000-0002-6601-2165
creation_date: 2018-03-13T23:55:19Z
@@ -17165,7 +17161,7 @@ id: RO:0012011
name: indirectly causally upstream of
def: "p is indirectly causally upstream of q iff p is causally upstream of q and there exists some process r such that p is causally upstream of r and r is causally upstream of q." []
is_a: causally_upstream_of ! causally upstream of
-created_by: pg
+created_by: https://orcid.org/0000-0003-1813-6857
creation_date: 2022-09-26T06:07:17Z
[Typedef]
@@ -17174,7 +17170,7 @@ name: indirectly regulates
def: "p indirectly regulates q iff p is indirectly causally upstream of q and p regulates q." []
is_a: regulates ! regulates
is_a: RO:0012011 ! indirectly causally upstream of
-created_by: pg
+created_by: https://orcid.org/0000-0003-1813-6857
creation_date: 2022-09-26T06:08:01Z
[Typedef]
@@ -17184,7 +17180,7 @@ def: "A relationship between a neuron and a region, where the neuron has a funct
synonym: "has synaptic input or output in" EXACT []
is_a: RO:0002130 ! has synaptic terminal in
transitive_over: part_of ! part_of
-created_by: http://orcid.org/0000-0002-1373-1705
+created_by: https://orcid.org/0000-0002-1373-1705
creation_date: 2020-07-17T09:26:52Z
[Typedef]
@@ -17196,7 +17192,7 @@ synonym: "has sensory terminal in" EXACT []
synonym: "has sensory terminal location" EXACT []
is_a: RO:0002360 ! has dendrite location
transitive_over: part_of ! part_of
-created_by: http://orcid.org/0000-0002-1373-1705
+created_by: https://orcid.org/0000-0002-1373-1705
creation_date: 2020-07-20T12:10:09Z
[Typedef]
@@ -17238,8 +17234,8 @@ comment: Example: a spherical object has the quality of being spherical, and the
id: RO:0015015
name: has high plasma membrane amount
def: "A relation between a cell and molecule or complex such that every instance of the cell has a high number of instances of that molecule expressed on the cell surface." [PMID:19243617]
-property_value: dc-contributor http://orcid.org/0000-0003-1617-8244
-property_value: dc-contributor http://orcid.org/0000-0003-1940-6740
+property_value: dc-contributor https://orcid.org/0000-0003-1617-8244
+property_value: dc-contributor https://orcid.org/0000-0003-1940-6740
property_value: IAO:0000112 "'Ly-76 high positive erythrocyte' equivalent to 'enucleate erythrocyte' and (has_high_plasma_membrane_amount some 'lymphocyte antigen 76 (mouse)')" xsd:string
domain: CL:0000000 ! cell
is_a: RO:0002104 ! has plasma membrane part
@@ -17248,8 +17244,8 @@ is_a: RO:0002104 ! has plasma membrane part
id: RO:0015016
name: has low plasma membrane amount
def: "A relation between a cell and molecule or complex such that every instance of the cell has a low number of instances of that molecule expressed on the cell surface." [PMID:19243617]
-property_value: dc-contributor http://orcid.org/0000-0003-1617-8244
-property_value: dc-contributor http://orcid.org/0000-0003-1940-6740
+property_value: dc-contributor https://orcid.org/0000-0003-1617-8244
+property_value: dc-contributor https://orcid.org/0000-0003-1940-6740
property_value: IAO:0000112 "'DN2b thymocyte' equivalent to 'DN2 thymocyte' and (has_low_plasma_membrane_amount some 'mast/stem cell growth factor receptor')" xsd:string
domain: CL:0000000 ! cell
is_a: RO:0002104 ! has plasma membrane part
@@ -17267,6 +17263,16 @@ property_value: IAO:0000232 "See github ticket https://github.com/oborel/obo-rel
holds_over_chain: capable_of has_input
creation_date: 2021-11-08T12:00:00Z
+[Typedef]
+id: RO:0017003
+name: positively correlated with
+def: "A relation between entities in which one increases or decreases as the other does the same." []
+property_value: dc-contributor https://orcid.org/0000-0003-1909-9269
+property_value: IAO:0000118 "directly correlated with" xsd:string
+is_reflexive: true
+is_symmetric: true
+is_a: RO:0002610 ! correlated with
+
[Typedef]
id: acts_on_population_of
name: acts on population of
@@ -17277,7 +17283,7 @@ subset: http://purl.obolibrary.org/obo/valid_for_go_ontology
subset: http://purl.obolibrary.org/obo/valid_for_gocam
xref: RO:0012003
is_a: has_participant ! has participant
-created_by: pg
+created_by: https://orcid.org/0000-0003-1813-6857
creation_date: 2020-06-08T17:21:33Z
[Typedef]
@@ -17337,8 +17343,8 @@ namespace: uberon
def: "a is attached to part of b if a is attached to b, or a is attached to some p, where p is part of b." []
xref: RO:0002177
property_value: IAO:0000589 "attached to part of (anatomical structure to anatomical structure)" xsd:string
-domain: CARO:0000003 ! connected anatomical structure
-range: CARO:0000003 ! connected anatomical structure
+domain: UBERON:0000061 ! anatomical structure
+range: UBERON:0000061 ! anatomical structure
holds_over_chain: attaches_to part_of {http://purl.obolibrary.org/obo/RO_0002582="true"}
is_a: RO:0002323 ! mereotopologically related to
is_a: RO:0002567 ! biomechanically related to
@@ -17468,6 +17474,7 @@ subset: http://purl.obolibrary.org/obo/valid_for_gocam
xref: RO:0002305
property_value: http://purl.org/dc/terms/creator https://orcid.org/0000-0002-6601-2165
property_value: RO:0004050 RO:0002411
+property_value: seeAlso https://wiki.geneontology.org/Causally_upstream_of,_negative_effect
is_a: causally_upstream_of ! causally upstream of
is_a: RO:0004046 ! causally upstream of or within, negative effect
@@ -17482,6 +17489,7 @@ subset: http://purl.obolibrary.org/obo/valid_for_gocam
xref: RO:0002304
property_value: http://purl.org/dc/terms/creator https://orcid.org/0000-0002-6601-2165
property_value: RO:0004049 RO:0002411
+property_value: seeAlso https://wiki.geneontology.org/Causally_upstream_of,_positive_effect
is_a: causally_upstream_of ! causally upstream of
is_a: RO:0004047 ! causally upstream of or within, positive effect
@@ -17689,8 +17697,8 @@ property_value: IAO:0000119 " Developmental Biology, Gilbert, 8th edition, figur
property_value: IAO:0000119 "GO:0001759" xsd:string
property_value: IAO:0000119 http://www.ncbi.nlm.nih.gov/pubmed/20064205
property_value: IAO:0000232 "We place this under 'developmentally preceded by'. This placement should be examined in the context of reciprocal inductions[cjm]" xsd:string
-domain: CARO:0000006 ! material anatomical entity
-range: CARO:0000006 ! material anatomical entity
+domain: UBERON:0000465 ! material anatomical entity
+range: UBERON:0000465 ! material anatomical entity
is_a: RO:0002258 ! developmentally preceded by
inverse_of: RO:0002257 ! developmentally induces
@@ -17746,7 +17754,7 @@ property_value: IAO:0000114 IAO:0000125
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000119 "EHDAA2" xsd:string
property_value: IAO:0000119 "Jonathan Bard, EHDAA2" xsd:string
-domain: CARO:0000000 ! anatomical entity
+domain: UBERON:0001062 ! anatomical entity
holds_over_chain: directly_develops_from located_in
is_a: RO:0002258 ! developmentally preceded by
@@ -17778,6 +17786,7 @@ xref: RO:0002630
property_value: IAO:0000119 http://purl.obolibrary.org/obo/ro/docs/causal-relations
property_value: IAO:0000589 "directly negatively regulates (process to process)" xsd:string
property_value: RO:0004050 RO:0002578
+property_value: seeAlso "https://wiki.geneontology.org/Directly_negatively_regulates" xsd:anyURI
is_a: directly_regulates ! directly regulates
is_a: negatively_regulates ! negatively regulates
@@ -17793,6 +17802,7 @@ xref: RO:0002629
property_value: IAO:0000119 http://purl.obolibrary.org/obo/ro/docs/causal-relations
property_value: IAO:0000589 "directly positively regulates (process to process)" xsd:string
property_value: RO:0004049 RO:0002578
+property_value: seeAlso "https://wiki.geneontology.org/Directly_positively_regulates" xsd:anyURI
is_a: directly_regulates ! directly regulates
is_a: positively_regulates ! positively regulates
@@ -17854,7 +17864,13 @@ is_a: connected_to ! connected to
id: editor_note
name: editor note
namespace: uberon
+def: "An administrative note intended for its editor. It may not be included in the publication version of the ontology, so it should contain nothing necessary for end users to understand the ontology." []
xref: IAO:0000116
+property_value: IAO:0000111 "editor note" xsd:string
+property_value: IAO:0000114 IAO:0000122
+property_value: IAO:0000117 "PERSON:Daniel Schober" xsd:string
+property_value: IAO:0000119 "GROUP:OBI:" xsd:string
+property_value: isDefinedBy http://purl.obolibrary.org/obo/iao.owl
is_metadata_tag: true
[Typedef]
@@ -18054,8 +18070,8 @@ xref: RO:0002254
property_value: IAO:0000112 "Mammalian thymus has developmental contribution from some pharyngeal pouch 3; Mammalian thymus has developmental contribution from some pharyngeal pouch 4 [Kardong]" xsd:string
property_value: IAO:0000114 IAO:0000125
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
-domain: CARO:0000000 ! anatomical entity
-range: CARO:0000000 ! anatomical entity
+domain: UBERON:0001062 ! anatomical entity
+range: UBERON:0001062 ! anatomical entity
holds_over_chain: has_part develops_from
is_a: RO:0002258 ! developmentally preceded by
inverse_of: RO:0002255 ! developmentally contributes to
@@ -18096,6 +18112,7 @@ xref: RO:0002233
property_value: IAO:0000114 IAO:0000125
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000118 "consumes" xsd:string
+property_value: seeAlso "https://wiki.geneontology.org/Has_input" xsd:anyURI
domain: BFO:0000015 ! process
holds_over_chain: starts_with has_input
is_a: has_participant ! has participant
@@ -18138,7 +18155,7 @@ xref: RO:0002373
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000119 "Wikipedia:Insertion_(anatomy)" xsd:string
property_value: seeAlso http://dbpedia.org/property/insertion
-domain: CARO:0000003 {http://purl.obolibrary.org/obo/IAO_0000116="We need to import uberon muscle into RO to use as a stricter domain constraint"} ! connected anatomical structure
+domain: UBERON:0000061 {http://purl.obolibrary.org/obo/IAO_0000116="We need to import uberon muscle into RO to use as a stricter domain constraint"} ! anatomical structure
is_a: attaches_to ! attached to
is_a: RO:0002567 ! biomechanically related to
@@ -18151,7 +18168,7 @@ xref: RO:0002372
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000119 "Wikipedia:Insertion_(anatomy)" xsd:string
property_value: seeAlso http://dbpedia.org/property/origin
-domain: CARO:0000003 {comment="We need to import uberon muscle to create a stricter domain constraint"} ! connected anatomical structure
+domain: UBERON:0000061 {comment="We need to import uberon muscle to create a stricter domain constraint"} ! anatomical structure
is_a: attaches_to ! attached to
is_a: RO:0002567 ! biomechanically related to
@@ -18164,7 +18181,7 @@ comment: By convention GO molecular functions are classified by their effector f
xref: RO:0002014
is_a: has_regulatory_component_activity ! has regulatory component activity
is_a: negatively_regulated_by ! negatively regulated by
-created_by: dos
+created_by: https://orcid.org/0000-0002-7073-9172
creation_date: 2017-05-24T09:31:01Z
[Typedef]
@@ -18172,7 +18189,10 @@ id: has_ontology_root_term
name: has ontology root term
name: preferred_root
namespace: uberon
+def: "Ontology annotation property. Relates an ontology to a term that is a designated root term of the ontology. Display tools like OLS can use terms annotated with this property as the starting point for rendering the ontology class hierarchy. There can be more than one root." []
xref: IAO:0000700
+property_value: IAO:0000111 "has ontology root term" xsd:string
+property_value: IAO:0000117 "Nicolas Matentzoglu" xsd:string
is_metadata_tag: true
[Typedef]
@@ -18188,6 +18208,7 @@ xref: RO:0002234
property_value: IAO:0000114 IAO:0000125
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000118 "produces" xsd:string
+property_value: seeAlso "https://wiki.geneontology.org/Has_output" xsd:anyURI
holds_over_chain: ends_with has_output
is_a: has_participant ! has participant
inverse_of: output_of ! output of
@@ -18257,7 +18278,7 @@ is_a: RO:0002384 ! has developmental potential involving
id: has_primary_input
name: has primary input
namespace: external
-def: "p has primary input c if (a) p has input c and (b) the goal of process is to modify, consume, or transform c." [GOC:cjm, GOC:dph, GOC:kva, GOC:pt] {comment="PMID:27812932"}
+def: "p has primary input c if (a) p has input c and (b) the goal of process is to modify, consume, or transform c." [GOC:dph, GOC:kva, GOC:pt, https://orcid.org/0000-0002-6601-2165] {comment="PMID:27812932"}
subset: http://purl.obolibrary.org/obo/valid_for_go_ontology
xref: RO:0004009
is_a: has_input ! has input
@@ -18280,7 +18301,7 @@ creation_date: 2018-12-13T11:26:17Z
id: has_primary_output
name: has primary output
namespace: external
-def: "p has primary output c if (a) p has output c and (b) the goal of process is to modify, produce, or transform c." [GOC:cjm, GOC:dph, GOC:kva, GOC:pt] {comment="PMID:27812932"}
+def: "p has primary output c if (a) p has output c and (b) the goal of process is to modify, produce, or transform c." [GOC:dph, GOC:kva, GOC:pt, https://orcid.org/0000-0002-6601-2165] {comment="PMID:27812932"}
subset: http://purl.obolibrary.org/obo/valid_for_go_ontology
xref: RO:0004008
is_a: has_output ! has output
@@ -18307,7 +18328,7 @@ def: "A 'has regulatory component activity' B if A and B are GO molecular functi
xref: RO:0002013
is_a: regulated_by ! regulated by
is_a: RO:0002017 ! has component activity
-created_by: dos
+created_by: https://orcid.org/0000-0002-7073-9172
creation_date: 2017-05-24T09:30:46Z
[Typedef]
@@ -18320,9 +18341,9 @@ property_value: IAO:0000112 "Forelimb SubClassOf has_skeleton some 'Forelimb ske
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000118 "has supporting framework" xsd:string
property_value: IAO:0000232 "The skeleton of a structure may be a true skeleton (for example, the bony skeleton of a hand) or any kind of support framework (the hydrostatic skeleton of a sea star, the exoskeleton of an insect, the cytoskeleton of a cell)." xsd:string
-domain: CARO:0000003 ! connected anatomical structure
+domain: UBERON:0000061 ! anatomical structure
domain: UBERON:0000475 ! organism subdivision
-range: CARO:0000006 {http://purl.obolibrary.org/obo/IAO_0000116="This should be to a more restricted class, but not the Uberon class may be too restricted since it is a composition-based definition of skeleton rather than functional."} ! material anatomical entity
+range: UBERON:0000465 {http://purl.obolibrary.org/obo/IAO_0000116="This should be to a more restricted class, but not the Uberon class may be too restricted since it is a composition-based definition of skeleton rather than functional."} ! material anatomical entity
range: UBERON:0010912 ! subdivision of skeleton
is_a: has_part ! has part
inverse_of: skeleton_of ! skeleton of
@@ -18523,7 +18544,6 @@ property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000119 http://www.ncbi.nlm.nih.gov/pubmed/17921072
property_value: IAO:0000119 http://www.ncbi.nlm.nih.gov/pubmed/20973947
property_value: seeAlso https://github.com/obophenotype/uberon/wiki/Taxon-constraints
-range: CARO:0001010 ! organism
holds_over_chain: attaches_to in_taxon
holds_over_chain: capable_of in_taxon
holds_over_chain: connected_to in_taxon
@@ -18565,7 +18585,7 @@ namespace: uberon
xref: RO:0002005
property_value: http://purl.org/spar/cito/citesAsAuthority "http://www.ncbi.nlm.nih.gov/pubmed/22402613" xsd:anyURI
property_value: IAO:0000117 https://orcid.org/0000-0002-7073-9172
-domain: CARO:0000003 ! connected anatomical structure
+domain: UBERON:0000061 ! anatomical structure
inverse_of: innervates ! innervates
transitive_over: branching_part_of ! branching part of
@@ -18624,6 +18644,7 @@ property_value: IAO:0000112 "my brain is located in my head" xsd:string
property_value: IAO:0000112 "this rat is located in this cage" xsd:string
property_value: IAO:0000118 "located_in" xsd:string
property_value: RO:0001900 RO:0001901
+property_value: seeAlso "https://wiki.geneontology.org/Located_in" xsd:anyURI
domain: BFO:0000004 {http://purl.obolibrary.org/obo/IAO_0000116="This is redundant with the more specific 'independent and not spatial region' constraint. We leave in the redundant axiom for use with reasoners that do not use negation."} ! independent continuant
range: BFO:0000004 {http://purl.obolibrary.org/obo/IAO_0000116="This is redundant with the more specific 'independent and not spatial region' constraint. We leave in the redundant axiom for use with reasoners that do not use negation."} ! independent continuant
is_transitive: true
@@ -18652,7 +18673,7 @@ def: "x lumen_of y iff x is the space or substance that is part of y and does no
subset: ro-eco
xref: RO:0002571
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
-property_value: IAO:0000119 "GOC:cjm" xsd:string
+property_value: IAO:0000119 https://orcid.org/0000-0002-6601-2165
range: BFO:0000040 ! material entity
is_a: part_of ! part_of
@@ -18742,6 +18763,7 @@ property_value: IAO:0000118 "occurs_in" xsd:string
property_value: IAO:0000118 "unfolds in" xsd:string
property_value: IAO:0000118 "unfolds_in" xsd:string
property_value: isDefinedBy http://purl.obolibrary.org/obo/bfo.owl
+property_value: seeAlso "https://wiki.geneontology.org/Occurs_in" xsd:anyURI
domain: BFO:0000003 ! occurrent
range: BFO:0000004 ! independent continuant
holds_over_chain: part_of occurs_in
@@ -18828,6 +18850,7 @@ property_value: RO:0040042 BFO:0000031
property_value: seeAlso http://ontologydesignpatterns.org/wiki/Community:Parts_and_Collections
property_value: seeAlso http://ontologydesignpatterns.org/wiki/Submissions:PartOf
property_value: seeAlso "http://www.obofoundry.org/ro/#OBO_REL:part_of" xsd:string
+property_value: seeAlso "https://wiki.geneontology.org/Part_of" xsd:anyURI
is_transitive: true
is_a: overlaps ! overlaps
inverse_of: has_part ! has part
@@ -19109,7 +19132,7 @@ xref: RO:0002315
property_value: IAO:0000112 "an annotation of gene X to cell differentiation with results_in_maturation_of CL:0000057 (fibroblast) means that at the end of the process the input cell that did not have features of a fibroblast, now has the features of a fibroblast." xsd:string
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: IAO:0000119 "GOC:mtg_berkeley_2013" xsd:string
-range: CARO:0000003 ! connected anatomical structure
+range: UBERON:0000061 ! anatomical structure
is_a: results_in_changes_to_anatomical_or_cellular_structure ! results in changes to anatomical or cellular structure
is_a: results_in_developmental_progression_of ! results in developmental progression of
@@ -19161,7 +19184,7 @@ property_value: IAO:0000114 IAO:0000125
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
property_value: seeAlso Ontology:extensions
domain: GO:0008150 ! biological_process
-range: CARO:0000000 ! anatomical entity
+range: UBERON:0001062 ! anatomical entity
is_a: RO:0002324 ! developmentally related to
[Typedef]
@@ -19213,7 +19236,7 @@ subset: http://purl.obolibrary.org/obo/valid_for_go_ontology
subset: http://purl.obolibrary.org/obo/valid_for_gocam
xref: RO:0012008
is_a: results_in_organization_of ! results in organization of
-created_by: pg
+created_by: https://orcid.org/0000-0003-1813-6857
creation_date: 2021-02-26T07:28:29Z
[Typedef]
@@ -19328,11 +19351,13 @@ is_a: homologous_to ! shares ancestor with
id: simultaneous_with
name: simultaneous with
namespace: uberon
+def: "x simultaneous with y iff ω(x) = ω(y) and ω(α ) = ω(α), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point and '=' indicates the same instance in time." []
comment: t1 simultaneous_with t2 iff:= t1 before_or_simultaneous_with t2 and not (t1 before t2)
subset: ro-eco
xref: RO:0002082
property_value: IAO:0000117 "David Osumi-Sutherland" xsd:string
property_value: IAO:0000117 https://orcid.org/0000-0002-7073-9172
+is_symmetric: true
is_transitive: true
is_a: RO:0002081 ! before or simultaneous with
@@ -19351,8 +19376,8 @@ def: "inverse of has skeleton" []
subset: RO:0002259
xref: RO:0002576
property_value: IAO:0000117 https://orcid.org/0000-0002-6601-2165
-domain: CARO:0000003 ! connected anatomical structure
-range: CARO:0000003 ! connected anatomical structure
+domain: UBERON:0000061 ! anatomical structure
+range: UBERON:0000061 ! anatomical structure
is_a: part_of ! part_of
[Typedef]
@@ -19456,7 +19481,14 @@ id: term_tracker_item
name: term tracker item
namespace: external
namespace: uberon
+def: "An IRI or similar locator for a request or discussion of an ontology term." []
+comment: The 'tracker item' can associate a tracker with a specific ontology term.
xref: IAO:0000233
+property_value: IAO:0000111 "term tracker item" xsd:string
+property_value: IAO:0000112 "the URI for an OBI Terms ticket at sourceforge, such as https://sourceforge.net/p/obi/obi-terms/772/" xsd:string
+property_value: IAO:0000114 IAO:0000125
+property_value: IAO:0000117 "Person: Jie Zheng, Chris Stoeckert, Alan Ruttenberg" xsd:string
+property_value: IAO:0000119 "Person: Jie Zheng, Chris Stoeckert, Alan Ruttenberg" xsd:string
is_metadata_tag: true
is_class_level: true
diff --git a/src/ontology/subsets/blood_and_immune_upper_slim.owl b/src/ontology/subsets/blood_and_immune_upper_slim.owl
index 88f7e6eea..51b38e39d 100644
--- a/src/ontology/subsets/blood_and_immune_upper_slim.owl
+++ b/src/ontology/subsets/blood_and_immune_upper_slim.owl
@@ -23,6 +23,7 @@
xmlns:swrla="http://swrl.stanford.edu/ontologies/3.3/swrla.owl#"
xmlns:swrlb="http://www.w3.org/2003/11/swrlb#"
xmlns:terms="http://purl.org/dc/terms/"
+ xmlns:vocab="https://w3id.org/semapv/vocab/"
xmlns:terms1="http://www.geneontology.org/formats/oboInOwl#http://purl.org/dc/terms/"
xmlns:uberon="http://purl.obolibrary.org/obo/uberon#"
xmlns:ubprop="http://purl.obolibrary.org/obo/ubprop#"
@@ -30,8 +31,8 @@
xmlns:oboInOwl="http://www.geneontology.org/formats/oboInOwl#"
xmlns:ncbitaxon="http://purl.obolibrary.org/obo/ncbitaxon#">
-
- 2023-06-22
+
+ 2023-07-20
@@ -47,6 +48,12 @@
+
+
+
+
+
+
@@ -68,7 +75,34 @@
+ definition
+
+ The official definition, explaining the meaning of a class or property. Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions.
+ 2012-04-05:
+Barry Smith
+
+The official OBI definition, explaining the meaning of a class or property: 'Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions' is terrible.
+
+Can you fix to something like:
+
+A statement of necessary and sufficient conditions explaining the meaning of an expression referring to a class or property.
+
+Alan Ruttenberg
+
+Your proposed definition is a reasonable candidate, except that it is very common that necessary and sufficient conditions are not given. Mostly they are necessary, occasionally they are necessary and sufficient or just sufficient. Often they use terms that are not themselves defined and so they effectively can't be evaluated by those criteria.
+
+On the specifics of the proposed definition:
+
+We don't have definitions of 'meaning' or 'expression' or 'property'. For 'reference' in the intended sense I think we use the term 'denotation'. For 'expression', I think we you mean symbol, or identifier. For 'meaning' it differs for class and property. For class we want documentation that let's the intended reader determine whether an entity is instance of the class, or not. For property we want documentation that let's the intended reader determine, given a pair of potential relata, whether the assertion that the relation holds is true. The 'intended reader' part suggests that we also specify who, we expect, would be able to understand the definition, and also generalizes over human and computer reader to include textual and logical definition.
+
+Personally, I am more comfortable weakening definition to documentation, with instructions as to what is desirable.
+
+We also have the outstanding issue of how to aim different definitions to different audiences. A clinical audience reading chebi wants a different sort of definition documentation/definition from a chemistry trained audience, and similarly there is a need for a definition that is adequate for an ontologist to work with.
+ PERSON:Daniel Schober
+ GROUP:OBI:<http://purl.obolibrary.org/obo/obi>
+
definition
+ definition
@@ -76,12 +110,19 @@
+ editor note
+
+ An administrative note intended for its editor. It may not be included in the publication version of the ontology, so it should contain nothing necessary for end users to understand the ontology.
+ PERSON:Daniel Schober
+ GROUP:OBI:<http://purl.obofoundry.org/obo/obi>
IAO:0000116
uberon
editor_note
true
editor_note
+
editor note
+ editor note
@@ -106,7 +147,13 @@
-
+
+ has obsolescence reason
+ Relates an annotation property to an obsolescence reason. The values of obsolescence reasons come from a list of predefined terms, instances of the class obsolescence reason specification.
+ PERSON:Alan Ruttenberg
+ PERSON:Melanie Courtot
+ has obsolescence reason
+
@@ -119,6 +166,12 @@
+ term tracker item
+ the URI for an OBI Terms ticket at sourceforge, such as https://sourceforge.net/p/obi/obi-terms/772/
+
+ An IRI or similar locator for a request or discussion of an ontology term.
+ Person: Jie Zheng, Chris Stoeckert, Alan Ruttenberg
+ Person: Jie Zheng, Chris Stoeckert, Alan Ruttenberg
IAO:0000233
external
uberon
@@ -126,7 +179,9 @@
true
true
term_tracker_item
+ The 'tracker item' can associate a tracker with a specific ontology term.
term tracker item
+ term tracker item
@@ -134,7 +189,15 @@
+ expand expression to
+ ObjectProperty: RO_0002104
+Label: has plasma membrane part
+Annotations: IAO_0000424 "http://purl.obolibrary.org/obo/BFO_0000051 some (http://purl.org/obo/owl/GO#GO_0005886 and http://purl.obolibrary.org/obo/BFO_0000051 some ?Y)"
+
+ A macro expansion tag applied to an object property (or possibly a data property) which can be used by a macro-expansion engine to generate more complex expressions from simpler ones
+ Chris Mungall
expand expression to
+ expand expression to
@@ -166,12 +229,16 @@
+ has ontology root term
+ Ontology annotation property. Relates an ontology to a term that is a designated root term of the ontology. Display tools like OLS can use terms annotated with this property as the starting point for rendering the ontology class hierarchy. There can be more than one root.
+ Nicolas Matentzoglu
IAO:0000700
uberon
has_ontology_root_term
true
has_ontology_root_term
has ontology root term
+ has ontology root term
preferred_root
@@ -186,7 +253,14 @@
+ term replaced by
+
+ Use on obsolete terms, relating the term to another term that can be used as a substitute
+ Person:Alan Ruttenberg
+ Person:Alan Ruttenberg
+ Add as annotation triples in the granting ontology
term replaced by
+ term replaced by
@@ -512,6 +586,12 @@ WHERE {
+
+
+
+
+
+
@@ -1060,6 +1140,7 @@ WHERE {
+ a mis-spelling that is in common use and thus recorded
@@ -1876,6 +1957,12 @@ WHERE {
+
+
+
+
+
+
+
+
+ This document is about information artifacts and their representations
+
+ A (currently) primitive relation that relates an information artifact to an entity.
+ 7/6/2009 Alan Ruttenberg. Following discussion with Jonathan Rees, and introduction of "mentions" relation. Weaken the is_about relationship to be primitive.
+
+We will try to build it back up by elaborating the various subproperties that are more precisely defined.
+
+Some currently missing phenomena that should be considered "about" are predications - "The only person who knows the answer is sitting beside me" , Allegory, Satire, and other literary forms that can be topical without explicitly mentioning the topic.
+ person:Alan Ruttenberg
+ Smith, Ceusters, Ruttenberg, 2000 years of philosophy
+ is about
+
+
+
+
@@ -2743,6 +2850,7 @@ range: spatial region or site (immaterial continuant)
located_in
located in
located in
+ https://wiki.geneontology.org/Located_in
@@ -2810,7 +2918,7 @@ range: spatial region or site (immaterial continuant)
-
+
@@ -2873,7 +2981,7 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
A 'has regulatory component activity' B if A and B are GO molecular functions (GO_0003674), A has_component B and A is regulated by B.
- dos
+
2017-05-24T09:30:46Z
RO:0002013
external
@@ -2890,7 +2998,7 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
A relationship that holds between a GO molecular function and a component of that molecular function that negatively regulates the activity of the whole. More formally, A 'has regulatory component activity' B iff :A and B are GO molecular functions (GO_0003674), A has_component B and A is negatively regulated by B.
- dos
+
2017-05-24T09:31:01Z
RO:0002014
external
@@ -2908,7 +3016,7 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
A relationship that holds between a GO molecular function and a component of that molecular function that positively regulates the activity of the whole. More formally, A 'has regulatory component activity' B iff :A and B are GO molecular functions (GO_0003674), A has_component B and A is positively regulated by B.
- dos
+
2017-05-24T09:31:17Z
By convention GO molecular functions are classified by their effector function and internal regulatory functions are treated as components. So, for example calmodulin has a protein binding activity that has positive regulatory component activity calcium binding activity. Receptor tyrosine kinase activity is a tyrosine kinase activity that has positive regulatory component 'ligand binding'.
has positive regulatory component activity
@@ -2920,7 +3028,7 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
- dos
+
2017-05-24T09:44:33Z
A 'has component activity' B if A is A and B are molecular functions (GO_0003674) and A has_component B.
has component activity
@@ -2935,7 +3043,7 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
w 'has process component' p if p and w are processes, w 'has part' p and w is such that it can be directly disassembled into into n parts p, p2, p3, ..., pn, where these parts are of similar type.
- dos
+
2017-05-24T09:49:21Z
has component process
@@ -2947,7 +3055,7 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
A relationship between a process and a barrier, where the process occurs in a region spanning the barrier. For cellular processes the barrier is typically a membrane. Examples include transport across a membrane and membrane depolarization.
- dos
+
2017-07-20T17:19:37Z
occurs across
@@ -2959,7 +3067,7 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
- dos
+
2017-09-17T13:52:24Z
Process(P2) is directly regulated by process(P1) iff: P1 regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding regulates the kinase activity (P2) of protein B then P1 directly regulates P2.
directly regulated by
@@ -2968,7 +3076,7 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
Process(P2) is directly regulated by process(P1) iff: P1 regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding regulates the kinase activity (P2) of protein B then P1 directly regulates P2.
- GOC:dos
+
@@ -2979,7 +3087,7 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
Process(P2) is directly negatively regulated by process(P1) iff: P1 negatively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding negatively regulates the kinase activity (P2) of protein B then P2 directly negatively regulated by P1.
- dos
+
2017-09-17T13:52:38Z
directly negatively regulated by
@@ -2987,7 +3095,7 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
Process(P2) is directly negatively regulated by process(P1) iff: P1 negatively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding negatively regulates the kinase activity (P2) of protein B then P2 directly negatively regulated by P1.
- GOC:dos
+
@@ -2998,7 +3106,7 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
Process(P2) is directly postively regulated by process(P1) iff: P1 positively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding positively regulates the kinase activity (P2) of protein B then P2 is directly postively regulated by P1.
- dos
+
2017-09-17T13:52:47Z
directly positively regulated by
@@ -3006,7 +3114,7 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
Process(P2) is directly postively regulated by process(P1) iff: P1 positively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding positively regulates the kinase activity (P2) of protein B then P2 is directly postively regulated by P1.
- GOC:dos
+
@@ -3017,7 +3125,7 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
A 'has effector activity' B if A and B are GO molecular functions (GO_0003674), A 'has component activity' B and B is the effector (output function) of B. Each compound function has only one effector activity.
- dos
+
2017-09-22T14:14:36Z
This relation is designed for constructing compound molecular functions, typically in combination with one or more regulatory component activity relations.
has effector activity
@@ -3026,7 +3134,7 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
A 'has effector activity' B if A and B are GO molecular functions (GO_0003674), A 'has component activity' B and B is the effector (output function) of B. Each compound function has only one effector activity.
- GOC:dos
+
@@ -3048,7 +3156,9 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
+
+ x simultaneous with y iff ω(x) = ω(y) and ω(α ) = ω(α), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point and '=' indicates the same instance in time.
David Osumi-Sutherland
RO:0002082
@@ -3129,14 +3239,14 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
-
+
+ Relation between a neuron and a material anatomical entity that its soma is part of.
Relation between a neuron and an anatomical structure that its soma is part of.
- Relation between a neuron and an anatomical structure that its soma is part of.
<http://purl.obolibrary.org/obo/BFO_0000051> some (
<http://purl.obolibrary.org/obo/GO_0043025> and <http://purl.obolibrary.org/obo/BFO_0000050> some ?Y)
@@ -3274,8 +3384,8 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
-
-
+
+
Every B cell[CL_0000236] has plasma membrane part some immunoglobulin complex[GO_0019814]
Holds between a cell c and a protein complex or protein p if and only if that cell has as part a plasma_membrane[GO:0005886], and that plasma membrane has p as part.
@@ -3624,7 +3734,6 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.
-
@@ -3801,8 +3910,8 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.
-
-
+
+
@@ -3934,7 +4043,7 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.
-
+
@@ -3956,16 +4065,16 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.
-
+
-
+
@@ -4326,7 +4435,7 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.
-
+
@@ -4464,6 +4573,7 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.has_input
has input
has input
+ https://wiki.geneontology.org/Has_input
@@ -4491,6 +4601,7 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.has_output
has output
has output
+ https://wiki.geneontology.org/Has_output
@@ -4500,8 +4611,8 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.
-
-
+
+
@@ -4543,8 +4654,8 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.
-
-
+
+
t1 induced_by t2 if there is a process of developmental induction (GO:0031128) with t1 and t2 as interacting participants. t2 causes t1 to change its fate from a precursor material anatomical entity type T to T', where T' develops_from T
@@ -4626,7 +4737,7 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.affects
acts upstream of or within
-
+ https://wiki.geneontology.org/Acts_upstream_of_or_within
@@ -4683,7 +4794,7 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.
- Inverse of 'expressed in'
+ y expresses x if and only if there is a gene expression process (GO:0010467) that occurs in y, and one of the following holds: (i) x is a gene, and x is transcribed into a transcript as part of the gene expression process (ii) x is a transcript, and x was transcribed from a gene as part of the gene expression process (iii) x is a mature gene product (protein or RNA), and x was translated or otherwise processed from a transcript that was transcribed as part of the gene expression process.
expresses
@@ -4695,7 +4806,7 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.
-
+
p results in the developmental progression of s iff p is a developmental process and s is an anatomical entity and p causes s to undergo a change in state at some point along its natural developmental cycle (this cycle starts with its formation, through the mature structure, and ends with its loss).
This property and its subproperties are being used primarily for the definition of GO developmental processes. The property hierarchy mirrors the core GO hierarchy. In future we may be able to make do with a more minimal set of properties, but due to the way GO is currently structured we require highly specific relations to avoid incorrect entailments. To avoid this, the corresponding genus terms in GO should be declared mutually disjoint.
@@ -4822,6 +4933,7 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.causally_upstream_of,_positive_effect
holds between x and y if and only if x is causally upstream of y and the progression of x increases the frequency, rate or extent of y
causally upstream of, positive effect
+
@@ -4841,6 +4953,7 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.
causally_upstream_of,_negative_effect
causally upstream of, negative effect
+
@@ -4883,7 +4996,7 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.
-
+
an annotation of gene X to cell differentiation with results_in_maturation_of CL:0000057 (fibroblast) means that at the end of the process the input cell that did not have features of a fibroblast, now has the features of a fibroblast.
The relationship that links a specified entity with the process that results in an unspecified entity acquiring the features and characteristics of the specified entity
@@ -4959,6 +5072,7 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.This relation differs from the parent relation 'capable of' in that the parent is weaker and only expresses a capability that may not be actually realized, whereas this relation is always realized.
enables
+ https://wiki.geneontology.org/Enables
@@ -5035,7 +5149,7 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.actively involved in
enables part of
involved in
-
+ https://wiki.geneontology.org/Involved_in
@@ -5070,6 +5184,7 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.
enabled by
+ https://wiki.geneontology.org/Enabled_by
@@ -5374,7 +5489,7 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.
-
+
m has_muscle_origin s iff m is attached_to s, and it is the case that when m contracts, s does not move. The site of the origin tends to be more proximal and have greater mass than what the other end attaches to.
Wikipedia:Insertion_(anatomy)
@@ -5389,7 +5504,7 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.
-
+
We need to import uberon muscle to create a stricter domain constraint
@@ -5400,7 +5515,7 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.
-
+
m has_muscle_insertion s iff m is attaches_to s, and it is the case that when m contracts, s moves. Insertions are usually connections of muscle via tendon to bone.
Wikipedia:Insertion_(anatomy)
@@ -5415,7 +5530,7 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.
-
+
We need to import uberon muscle into RO to use as a stricter domain constraint
@@ -5520,8 +5635,8 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.
-
-
+
+
x has developmental potential involving y iff x is capable of a developmental process with output y. y may be the successor of x, or may be a different structure in the vicinity (as for example in the case of developmental induction).
@@ -5652,6 +5767,7 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.indirectly activates
indirectly positively regulates
+ https://wiki.geneontology.org/Indirectly_positively_regulates
@@ -5679,6 +5795,7 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.indirectly inhibits
indirectly negatively regulates
+ https://wiki.geneontology.org/Indirectly_negatively_regulates
@@ -5882,6 +5999,7 @@ Each of these 3 primitives can be composed to yield a cross-product of different
enables activity in
is active in
+ https://wiki.geneontology.org/Is_active_in
@@ -5896,8 +6014,8 @@ Each of these 3 primitives can be composed to yield a cross-product of different
c executes activity in d if and only if c enables p and p occurs_in d. Assuming no action at a distance by gene products, if a gene product enables (is capable of) a process that occurs in some structure, it must have at least some part in that structure.
- GOC:cjm
- GOC:dos
+
+
@@ -6408,9 +6526,9 @@ For example, A and B may be gene products and binding of B by A positively regul
-
+
-
+
Forelimb SubClassOf has_skeleton some 'Forelimb skeleton'
A relation between a segment or subdivision of an organism and the maximal subdivision of material entities that provides structural support for that segment or subdivision.
@@ -6426,7 +6544,7 @@ For example, A and B may be gene products and binding of B by A positively regul
-
+
This should be to a more restricted class, but not the Uberon class may be too restricted since it is a composition-based definition of skeleton rather than functional.
@@ -6516,8 +6634,8 @@ For example, A and B may be gene products and binding of B by A positively regul
-
-
+
+
A relation that holds between elements of a musculoskeletal system or its analogs.
Do not use this relation directly. It is ended as a grouping for a diverse set of relations, all involving the biomechanical processes.
@@ -6588,7 +6706,7 @@ For example, A and B may be gene products and binding of B by A positively regul
x lumen_of y iff x is the space or substance that is part of y and does not cross any of the inner membranes or boundaries of y that is maximal with respect to the volume of the convex hull.
- GOC:cjm
+
RO:0002571
uberon
lumen_of
@@ -6620,8 +6738,8 @@ For example, A and B may be gene products and binding of B by A positively regul
-
-
+
+
inverse of has skeleton
RO:0002576
@@ -6806,6 +6924,16 @@ For example, A and B may be gene products and binding of B by A positively regul
+
+
+
+ A relationship that holds between two entities, where the entities exhibit a statistical dependence relationship. The entities may be statistical variables, or they may be other kinds of entities such as diseases, chemical entities or processes.
+ Groups both positive and negative correlation
+ correlated with
+
+
+
+
@@ -6823,6 +6951,7 @@ For example, A and B may be gene products and binding of B by A positively regul
directly_positively_regulates
directly positively regulates
+ https://wiki.geneontology.org/Directly_positively_regulates
@@ -6844,6 +6973,7 @@ For example, A and B may be gene products and binding of B by A positively regul
directly_negatively_regulates
directly negatively regulates
+ https://wiki.geneontology.org/Directly_negatively_regulates
@@ -6932,7 +7062,7 @@ For example, A and B may be gene products and binding of B by A positively regul
p has primary output c if (a) p has output c and (b) the goal of process is to modify, produce, or transform c.
- GOC:cjm
+
GOC:dph
GOC:kva
GOC:pt
@@ -6960,7 +7090,7 @@ For example, A and B may be gene products and binding of B by A positively regul
p has primary input c if (a) p has input c and (b) the goal of process is to modify, consume, or transform c.
- GOC:cjm
+
GOC:dph
GOC:kva
GOC:pt
@@ -6998,7 +7128,7 @@ For example, A and B may be gene products and binding of B by A positively regul
2018-01-26T23:49:30Z
acts upstream of or within, positive effect
-
+ https://wiki.geneontology.org/Acts_upstream_of_or_within,_positive_effect
@@ -7016,6 +7146,7 @@ For example, A and B may be gene products and binding of B by A positively regul
2018-01-26T23:49:51Z
acts upstream of or within, negative effect
+ https://wiki.geneontology.org/Acts_upstream_of_or_within,_negative_effect
@@ -7035,7 +7166,7 @@ For example, A and B may be gene products and binding of B by A positively regul
2018-01-26T23:53:14Z
acts upstream of, positive effect
-
+ https://wiki.geneontology.org/Acts_upstream_of,_positive_effect
@@ -7055,7 +7186,7 @@ For example, A and B may be gene products and binding of B by A positively regul
2018-01-26T23:53:22Z
acts upstream of, negative effect
-
+ https://wiki.geneontology.org/Acts_upstream_of,_negative_effect
@@ -7068,6 +7199,7 @@ For example, A and B may be gene products and binding of B by A positively regul
2018-03-13T23:55:05Z
causally upstream of or within, negative effect
+ https://wiki.geneontology.org/Causally_upstream_of_or_within,_negative_effect
@@ -7080,6 +7212,7 @@ For example, A and B may be gene products and binding of B by A positively regul
2018-03-13T23:55:19Z
causally upstream of or within, positive effect
+
@@ -7102,7 +7235,7 @@ For example, A and B may be gene products and binding of B by A positively regul
p acts on population of c iff c' is a collection, has members of type c, and p has participant c
- pg
+
2020-06-08T17:21:33Z
RO:0012003
external
@@ -7121,7 +7254,7 @@ For example, A and B may be gene products and binding of B by A positively regul
- pg
+
2021-02-26T07:28:29Z
RO:0012008
external
@@ -7141,7 +7274,7 @@ For example, A and B may be gene products and binding of B by A positively regul
p is indirectly causally upstream of q iff p is causally upstream of q and there exists some process r such that p is causally upstream of r and r is causally upstream of q.
- pg
+
2022-09-26T06:07:17Z
indirectly causally upstream of
@@ -7154,7 +7287,7 @@ For example, A and B may be gene products and binding of B by A positively regul
p indirectly regulates q iff p is indirectly causally upstream of q and p regulates q.
- pg
+
2022-09-26T06:08:01Z
indirectly regulates
@@ -7170,7 +7303,7 @@ For example, A and B may be gene products and binding of B by A positively regul
A relationship between a neuron and a region, where the neuron has a functionally relevant number of input and/or output synapses in that region.
-
+
2020-07-17T09:26:52Z
has synaptic input or output in
has synaptic IO in region
@@ -7187,7 +7320,7 @@ For example, A and B may be gene products and binding of B by A positively regul
Relation between a sensory neuron and some structure in which it receives sensory input via a sensory dendrite.
-
+
2020-07-20T12:10:09Z
has sensory dendrite location
has sensory terminal in
@@ -7283,8 +7416,8 @@ For example, A and B may be gene products and binding of B by A positively regul
'Ly-76 high positive erythrocyte' equivalent to 'enucleate erythrocyte' and (has_high_plasma_membrane_amount some 'lymphocyte antigen 76 (mouse)')
A relation between a cell and molecule or complex such that every instance of the cell has a high number of instances of that molecule expressed on the cell surface.
-
-
+
+
has high plasma membrane amount
@@ -7303,8 +7436,8 @@ For example, A and B may be gene products and binding of B by A positively regul
'DN2b thymocyte' equivalent to 'DN2 thymocyte' and (has_low_plasma_membrane_amount some 'mast/stem cell growth factor receptor')
A relation between a cell and molecule or complex such that every instance of the cell has a low number of instances of that molecule expressed on the cell surface.
-
-
+
+
has low plasma membrane amount
@@ -7336,6 +7469,20 @@ For example, A and B may be gene products and binding of B by A positively regul
+
+
+
+
+
+
+ A relation between entities in which one increases or decreases as the other does the same.
+ directly correlated with
+
+ positively correlated with
+
+
+
+
@@ -7807,7 +7954,8 @@ For example, A and B may be gene products and binding of B by A positively regul
- A continuant that is a bearer of quality and realizable entity entities, in which other entities inhere and which itself cannot inhere in anything.
+ b is an independent continuant = Def. b is a continuant which is such that there is no c and no t such that b s-depends_on c at t. (axiom label in BFO2 Reference: [017-002])
+ A continuant that is a bearer of quality and realizable entity entities, in which other entities inhere and which itself cannot inhere in anything.
independent continuant
@@ -7817,7 +7965,8 @@ For example, A and B may be gene products and binding of B by A positively regul
- An occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t.
+ p is a process = Def. p is an occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t. (axiom label in BFO2 Reference: [083-003])
+ An occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t.
process
@@ -7833,7 +7982,8 @@ For example, A and B may be gene products and binding of B by A positively regul
- A continuant that inheres in or is borne by other entities. Every instance of A requires some specific instance of B which must always be the same.
+ b is a specifically dependent continuant = Def. b is a continuant & there is some independent continuant c which is not a spatial region and which is such that b s-depends_on c at every time t during the course of b’s existence. (axiom label in BFO2 Reference: [050-003])
+ A continuant that inheres in or is borne by other entities. Every instance of A requires some specific instance of B which must always be the same.
specifically dependent continuant
@@ -8492,7 +8642,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -8868,7 +9017,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -9176,7 +9324,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -9316,7 +9463,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -9456,7 +9602,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -9816,7 +9961,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -10986,7 +11130,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -11167,7 +11310,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -11258,7 +11400,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -11741,7 +11882,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -11922,7 +12062,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -12056,7 +12195,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -12124,7 +12262,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -12379,7 +12516,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -12467,7 +12603,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -12593,7 +12728,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -13360,7 +13494,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -13458,7 +13591,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -13505,7 +13637,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -14101,7 +14232,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -14354,7 +14484,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -14636,7 +14765,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -15049,7 +15177,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -15386,7 +15513,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -15565,7 +15691,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -15656,7 +15781,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -15701,7 +15825,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -15747,7 +15870,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -15786,7 +15908,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -16375,7 +16496,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -16488,7 +16608,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -16600,7 +16719,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -34616,6 +34734,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PR:000001006
Category=gene. Requested by=CL.
receptor-type tyrosine-protein phosphatase C
+
@@ -34665,6 +34784,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PR:000001012
Category=gene. Requested by=CL.
integrin alpha-M
+
@@ -34711,6 +34831,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PR:000001013
Category=gene. Requested by=CL.
integrin alpha-X
+
@@ -34848,6 +34969,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PR:000001024
Category=gene. Requested by=CL.
neural cell adhesion molecule 1
+
@@ -34932,6 +35054,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PR:000001084
Category=gene. Requested by=CL.
T-cell surface glycoprotein CD8 alpha chain
+
@@ -35082,6 +35205,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PR:000001254
Category=gene. Requested by=CL.
C-C chemokine receptor type 1
+
@@ -35139,6 +35263,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PR:000001255
Category=gene. Requested by=CL.
C-C chemokine receptor type 3
+
@@ -35352,6 +35477,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PR:000001332
Category=gene. Requested by=CL.
carcinoembryonic antigen-related cell adhesion molecule 8
+
@@ -35438,6 +35564,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PR:000001344
Category=gene. Requested by=CL.
ectonucleotide pyrophosphatase/phosphodiesterase family member 3
+
@@ -35523,6 +35650,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PR:000001408
Category=gene. Requested by=CL.
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
+
@@ -35554,6 +35682,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PR:000001444
Category=gene. Requested by=CL.
cadherin-5
+
@@ -35675,6 +35804,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PR:000001839
Category=gene. Requested by=CL.
T-cell surface glycoprotein CD5
+
@@ -35714,6 +35844,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PR:000001850
Category=gene. Requested by=CL.
cathepsin K
+
@@ -35831,6 +35962,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PR:000001867
Category=gene. Requested by=CL.
interleukin-5 receptor subunit alpha
+
@@ -35872,6 +36004,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PR:000001869
Category=gene. Requested by=CL.
interleukin-7 receptor subunit alpha
+
@@ -35928,6 +36061,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PR:000001879
Category=gene. Requested by=CL.
leukosialin
+
@@ -36004,6 +36138,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PR:000001898
Category=gene. Requested by=CL.
neprilysin
+
@@ -36040,6 +36175,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PR:000001903
Category=gene. Requested by=CL.
paired box protein PAX-5
+
@@ -36082,6 +36218,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PR:000001932
Category=gene. The mouse ortholog is Cd24a. Mouse protein Cd24b likely also orthologous. Currently it is not in UniProt. Requested by=CL.
signal transducer CD24
+
@@ -36120,6 +36257,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PR:000001935
Category=gene. Requested by=CL.
syndecan-1
+
@@ -36166,6 +36304,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PR:000001937
Category=gene. Requested by=CL.
tartrate-resistant acid phosphatase type 5
+
@@ -36209,6 +36348,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PR:000001944
Category=gene. Requested by=CL.
transcription factor PU.1
+
@@ -36255,6 +36395,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PR:000001945
Category=gene. Requested by=CL.
transferrin receptor protein 1
+
@@ -36355,6 +36496,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PR:000001954
Category=gene. Requested by=CL.
tumor necrosis factor receptor superfamily member 11A
+
@@ -36435,6 +36577,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PR:000001969
Category=gene. Requested by=CL.
urokinase plasminogen activator surface receptor
+
@@ -36504,6 +36647,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PR:000002062
Category=gene. Requested by=CL.
macrophage colony-stimulating factor 1 receptor
+
@@ -36599,6 +36743,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PR:000002112
Category=gene. Requested by=CL.
vascular endothelial growth factor receptor 2
+
@@ -36794,6 +36939,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PR:000003457
Category=gene. Requested by=CL.
V(D)J recombination-activating protein 1
+
@@ -36828,6 +36974,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PR:000003460
Category=gene. Requested by=CL.
V(D)J recombination-activating protein 2
+
@@ -36920,6 +37067,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PR:000005307
Category=gene. Requested by=CL.
CCAAT/enhancer-binding protein alpha
+
@@ -36989,6 +37137,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PR:000006611
Category=gene. Requested by=CL.
DNA nucleotidylexotransferase
+
@@ -37027,6 +37176,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PR:000007431
Category=gene. Requested by=CL.
high affinity immunoglobulin epsilon receptor subunit alpha
+
@@ -37065,6 +37215,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PR:000007597
Category=gene. Requested by=CL.
protein c-Fos
+
@@ -37105,6 +37256,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PR:000007857
Category=gene. Requested by=CL.
erythroid transcription factor
+
@@ -37145,6 +37297,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PR:000007858
Category=gene. Requested by=CL.
endothelial transcription factor GATA-2
+
@@ -37176,6 +37329,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PR:000009143
Category=gene. Requested by=CL.
integrin beta-7
+
@@ -37210,6 +37364,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PR:000011178
Category=gene. Requested by=CL.
nuclear factor NF-kappa-B p100 subunit
+
@@ -37247,6 +37402,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PR:000014841
Category=gene.
sonic hedgehog protein
+
@@ -37288,6 +37444,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PR:000016043
Category=gene. Requested by=CL.
T-cell acute lymphocytic leukemia protein 1
+
@@ -37339,6 +37496,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PR:000016401
Category=gene. Requested by=CL.
transmembrane emp24 domain-containing protein 1
+
@@ -38772,6 +38930,8 @@ MH: sexual subtypes should probably be logically defined based on sexual process
Staged defined by the formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system.
+
+ In zebrafish, the times of neurulation and segmentation overlap so extensively there is no distinct neurula period of development, such as occurs largely before segmentation in amphibian embryos.
BILS:0000110
BilaDO:0000009
HsapDv:0000012
@@ -38780,6 +38940,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
uberon
UBERON:0000110
neurula stage
+ https://github.com/obophenotype/developmental-stage-ontologies/issues/84
https://github.com/obophenotype/uberon/issues/343
@@ -38802,12 +38963,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
-
-
-
-
-
@@ -38832,6 +38987,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
segmentation stage
UBERON:0000111
organogenesis stage
+ https://github.com/obophenotype/developmental-stage-ontologies/issues/84
https://github.com/obophenotype/uberon/issues/533
@@ -38904,7 +39060,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -38918,7 +39073,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
@@ -38991,7 +39146,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
https://github.com/obophenotype/uberon/issues/661
http://upload.wikimedia.org/wikipedia/commons/0/06/Mouth_illustration-Otis_Archives.jpg
-
+
@@ -39004,7 +39159,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
exceptions in some taxa
@@ -39121,7 +39276,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -39130,15 +39284,15 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
-
-
+
+
A fluid that is composed of blood plasma and erythrocytes.
This class excludes blood analogues, such as the insect analog of blood. See UBERON:0000179 haemolymphatic fluid.
@@ -39180,34 +39334,34 @@ MH: sexual subtypes should probably be logically defined based on sexual process
blood
-
+
-
+
-
+
-
+
CL:tm
-
+
https://github.com/obophenotype/uberon/issues/1330
-
+
Bgee:AN
@@ -39330,7 +39484,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -39396,7 +39549,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -39513,7 +39665,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
@@ -39555,14 +39707,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
organism substance
-
+
-
+
this relationship may be too strong and may be weakened in future
@@ -40526,7 +40678,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -40793,7 +40944,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
Primary germ layer that is the outer of the embryo's three germ layers and gives rise to epidermis and neural tissue.
Primary germ layer that is the outer of the embryonic germ layers and gives rise to epidermis and neural tissue.[AAO]
The Bilateria are triploblastic (with true endoderm, mesoderm, and ectoderm) (...).[well established][VHOG]
@@ -40831,14 +40982,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
ectoderm
http://upload.wikimedia.org/wikipedia/commons/1/19/Gray32.png
-
+
-
+
Bgee:AN
@@ -40891,7 +41042,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
Primary germ layer that lies remote from the surface of the embryo and gives rise to internal tissues such as gut.
The Bilateria are triploblastic (with true endoderm, mesoderm, and ectoderm) (...).[well established][VHOG]
endodermal
@@ -40928,14 +41079,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
http://upload.wikimedia.org/wikipedia/commons/c/c0/Endoderm2.png
http://upload.wikimedia.org/wikipedia/commons/d/df/Gray10.png
-
+
-
+
Bgee:AN
@@ -40980,7 +41131,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
The middle germ layer of the embryo, between the endoderm and ectoderm.
Primary germ layer that is the middle of the embryonic germ layers.[AAO]
@@ -41025,7 +41176,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
mesoderm
http://upload.wikimedia.org/wikipedia/commons/e/e8/Mesoderm.png
-
+
@@ -41038,7 +41189,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
Bgee:AN
@@ -41245,7 +41396,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
@@ -41319,14 +41470,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
Taxon notes:" the ascidian tube-like heart lacks chambers....The ascidian heart is formed after metamorphosis as a simple tube-like structure with a single-layered myoepithelium that is continuous with a single-layered pericar- dial wall. It lacks chambers and endocardium.... The innovation of the chambered heart was a key event in vertebrate evolution, because the chambered heart generates one-way blood flow with high pressure, a critical requirement for the efficient blood supply of large-body vertebrates... all extant vertebrates have hearts with two or more chambers (Moorman and Christoffels 2003)" DOI:10.1101/gad.1485706
heart
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+
-
+
MA
@@ -41858,7 +42009,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -41952,7 +42102,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -41984,7 +42133,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
@@ -42037,14 +42186,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
http://upload.wikimedia.org/wikipedia/commons/b/b2/TE-Nervous_system_diagram.svg
http://upload.wikimedia.org/wikipedia/commons/b/ba/Nervous_system_diagram.png
-
+
-
+
Bgee:AN
@@ -42132,7 +42281,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
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+
The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the neural tube derivatives: the brain and spinal cord. In invertebrates it includes central ganglia plus nerve cord.
Part of the nervous system which includes the brain and spinal cord.[AAO]
@@ -42179,7 +42328,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
central nervous system
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+
@@ -42193,7 +42342,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
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Bgee:AN
@@ -42687,7 +42836,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
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+
Skeletal element that is composed of bone tissue.
@@ -42737,14 +42886,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
bone element
-
+
-
+
VSAO-modified
@@ -42836,7 +42985,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -42856,7 +43004,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
A tube extending from the mouth to the anus.
@@ -42896,14 +43044,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
digestive tract
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+
-
+
NCBIBook:NBK10107
@@ -43172,7 +43320,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -43181,8 +43328,8 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
-
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+
@@ -43195,7 +43342,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
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@@ -43254,34 +43401,34 @@ MH: sexual subtypes should probably be logically defined based on sexual process
blood vessel
http://upload.wikimedia.org/wikipedia/commons/2/29/Circulatory_System_en.svg
-
+
-
+
-
+
-
+
AEO
-
+
EHDAA2
-
+
GO:0072360
@@ -43731,7 +43878,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -43986,7 +44132,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -44006,7 +44151,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
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@@ -44040,14 +44185,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
musculoskeletal system
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+
-
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check ctenophore
@@ -44175,9 +44320,8 @@ MH: sexual subtypes should probably be logically defined based on sexual process
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@@ -44218,14 +44362,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
coelemic cavity lumen
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+
-
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definitional
@@ -44333,9 +44477,9 @@ MH: sexual subtypes should probably be logically defined based on sexual process
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-
+
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@@ -44390,15 +44534,15 @@ MH: sexual subtypes should probably be logically defined based on sexual process
notochord
http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png
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-
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@@ -44417,19 +44561,19 @@ MH: sexual subtypes should probably be logically defined based on sexual process
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http://tolweb.org/Chordata/2499
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ZFA
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EHDAA2
@@ -44512,11 +44656,10 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
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+
Somites are spheres of epithelial cells that form sequentially along the anterior-posterior axis of the embryo through mesenchymal to epithelial transition of the presomitic mesoderm.
currently classified as an epithelial vesicle, consistent with EHDAA2 and https://github.com/obophenotype/uberon/wiki/The-neural-crest. Consider making 'somitic mesoderm' a separate term and correlate with regionalization processes. Consider moving ZFA term to 'trunk somite' as it is part of the trunk
@@ -44562,11 +44705,11 @@ MH: sexual subtypes should probably be logically defined based on sexual process
somite
http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png
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+
-
+
@@ -44579,13 +44722,13 @@ MH: sexual subtypes should probably be logically defined based on sexual process
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GOTAX:0000352
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ZFA
@@ -44698,12 +44841,12 @@ MH: sexual subtypes should probably be logically defined based on sexual process
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-
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A specialized region of ectoderm found between the neural ectoderm (neural plate) and non-neural ectoderm and composed of highly migratory pluripotent cells that delaminate in early embryonic development from the dorsal neural tube and give rise to an astounding variety of differentiated cell types[MP].
consider including subclasses for pre- and post- migratory (e.g. sheets/paths/streams).
@@ -44743,66 +44886,66 @@ MH: sexual subtypes should probably be logically defined based on sexual process
http://upload.wikimedia.org/wikipedia/commons/5/5f/Gray644.png
https://upload.wikimedia.org/wikipedia/commons/8/8f/Neural_Crest.png
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+
-
+
-
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-
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-
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-
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XAO
https://github.com/obophenotype/uberon/wiki/The-neural-crest
-
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Hall and others restrict NC to vertebrates but we opt for a less restrictive constraint to avoid inconsistencies when areas such as P1 area of pallium in hagfishes inherit cell lineage from telecephalon-contributing NC cells
ISBN:0073040584
-
+
BTO
-
+
PMID:11523831
-
+
pre migratory https://github.com/obophenotype/uberon/wiki/The-neural-crest
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+
PMID:11523831
@@ -44990,7 +45133,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
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@@ -45048,14 +45191,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
bone marrow
http://upload.wikimedia.org/wikipedia/commons/7/74/Gray72-en.svg
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+
-
+
FMA
MA
@@ -45324,17 +45467,16 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
-
+
-
+
Anatomical system that is involved in the production of hematopoietic cells.
Anatomical system that consists of the blood and blood forming tissues.[AAO]
@@ -45377,24 +45519,24 @@ MH: sexual subtypes should probably be logically defined based on sexual process
hematopoietic system
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+
-
+
-
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FMA
-
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definitional
@@ -45765,7 +45907,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
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Unsegmented field of paraxial mesoderm present posterior to the most recently formed somite pair, from which somites will form.
Unsegmented field of paraxial mesoderm present posterior to the most recently formed somite pair, from which somites will form. Kimmel et al, 1995.[TAO]
It is reasonable to assume that the proximate invertebrate ancestor of the vertebrates had an amphioxus-like tail bud in its larval stage. This archetypal tail bud would have (...) (3) lacked any component of mesenchyme cells, (4) budded off new mesodermal segments directly, without any intervening zone of presomitic mesoderm (...). Then, early in vertebrate evolution, epithelium-to-mesenchyme interconversions (and the gene networks for effecting them) became prominent features of development. (...) In any case, conspicuous mesenchymal components tended to be added to the vertebrate tail bud itself. In addition, a mesenchymatous presomitic mesoderm (not a part of the tail bud proper) came to intervene between the tail bud and the forming somites.[well established][VHOG]
@@ -45790,14 +45932,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
presomitic mesoderm
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+
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Bgee:AN
@@ -45960,7 +46102,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -46025,13 +46166,12 @@ MH: sexual subtypes should probably be logically defined based on sexual process
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-
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A region of embryonic ectodermal cells that lie directly above the notochord. During neurulation, they change shape and produce an infolding of the neural plate (the neural fold) that then seals to form the neural tube[XAO]. The earliest recognizable dorsal ectodermal primordium of the central nervous system present near the end of gastrulation before infolding to form the neural keel; consists of a thickened pseudostratified epithelium[ZFA].
The earliest recognizable dorsal ectodermal primordium of the central nervous system present near the end of gastrulation before infolding to form the neural keel; consists of a thickened pseudostratified epithelium. Kimmel et al, 1995.[TAO]
(...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...).[well established][VHOG]
@@ -46063,34 +46203,34 @@ MH: sexual subtypes should probably be logically defined based on sexual process
neural plate
https://upload.wikimedia.org/wikipedia/commons/8/8f/Neural_Crest.png
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+
-
+
-
+
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+
GOTAX:0000352
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Wikipedia
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Bgee:AN
@@ -46155,7 +46295,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
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+
The paraxial mesoderm is the mesoderm located bilaterally adjacent to the notochord and neural tube[GO].
Mesoderm lateral to the neural tube and notochord that is divided into cranial and post-cranial portions. The trunk portions further segment into somites.[AAO]
Presently, Cephalochordata, Urochordata, and Vertebrata are placed as subphyla of the phylum Chordata, in which the overall organization of embryonic tissues (dorsal hollow nerve cord, ventral digestive tract, axial notochord, and bilateral paraxial mesoderm) is largely conserved. In contrast, the echinoderms and hemichordates are sister groups of the chordates and they lack the notochord and paraxial mesoderm. Thus, the basic mesodermal organization of vertebrates must have appeared first in the common ancestor of the chordates.[well established][VHOG]
@@ -46184,7 +46324,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
paraxial mesoderm
http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png
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+
@@ -46197,7 +46337,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
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Bgee:AN
@@ -46269,7 +46409,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
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+
@@ -46313,7 +46453,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
lateral plate mesoderm
http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png
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+
@@ -46326,7 +46466,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
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EHDAA2
VHOG
@@ -46409,17 +46549,16 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
-
-
+
+
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Bilateral groups of cells consisting of three rows: one row of endocardial precursors medially and two rows of myocardical precursors laterally. The two populations fuse at the midline to form the heart rudiment or cone.
should probably be merged with heart rudiment.
Bilateral groups of cells consisting of three rows: one row of endocardial precursors medially and two rows of myocardical precursors laterally. The two populations fuse at the midline between 21 and 26 somites to form the heart rudiment or cone. Stainier 2001.[TAO]
@@ -46439,15 +46578,15 @@ MH: sexual subtypes should probably be logically defined based on sexual process
heart primordium
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@@ -46460,19 +46599,19 @@ MH: sexual subtypes should probably be logically defined based on sexual process
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ZFA
-
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ZFA
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XAO
@@ -46527,8 +46666,8 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
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+
Ventral somitic compartment that is a precursor of the axial skeleton[XAO]. Sclerotomes eventually differentiate into the vertebrae and most of the skull. The caudal (posterior) half of one sclerotome fuses with the rostral (anterior) half of the adjacent one to form each vertebra. From their initial location within the somite, the sclerotome cells migrate medially towards the notochord. These cells meet the sclerotome cells from the other side to form the vertebral body. From this vertebral body, sclerotome cells move dorsally and surround the developing spinal cord, forming the vertebral arch[WP].
Skeletogenic portion of somites.[AAO]
The vertebrate sclerotome has no equivalent in amphioxus and is a novelty linked with the evolution of the axial skeleton.[well established][VHOG]
@@ -46555,11 +46694,11 @@ MH: sexual subtypes should probably be logically defined based on sexual process
sclerotome
http://upload.wikimedia.org/wikipedia/commons/9/96/Gray65.png
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+
@@ -46578,13 +46717,13 @@ MH: sexual subtypes should probably be logically defined based on sexual process
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VHOG:0000680
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ZFA
@@ -46797,7 +46936,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -46844,7 +46982,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
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@@ -46852,7 +46989,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
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The part of the coelom in the embryo between the somatopleuric and splanchnopleuric mesoderm; the principal body cavities of the trunk (thoracic, abdominal, and pelvic) arise from this embryonic part of the coelom.
consider merging with coelom. TODO - add spatial relationships to halves of LPM. Note the OG places XAO and ZFA coelem terms here. editor note: TODO check ZFA, which appears to be a structure present in adults
(...) I regard it unlikely that coeloms of all bilaterian animals are comparable and evolved very early. Considering all these questions, few convincing characters concerning the evolution of body cavities remain to be named. (...) A segmental coelom appears to have evolved at least two times, in Annelida and in Myomerata (Acrania and Craniota).[well established][VHOG]
@@ -46868,14 +47005,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
intraembryonic coelom
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+
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Wikipedia
@@ -47052,7 +47189,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -47097,7 +47233,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -47131,7 +47266,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
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@@ -47197,8 +47331,8 @@ MH: sexual subtypes should probably be logically defined based on sexual process
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A specific region of the lateral mesoderm that will form the primary beating heart tube. In mammals the primary heart field gives rise to the left ventricle.
this term denotes the primary heart field; GO:0003128 denotes the superclass of primary and secondary: specific region of the lateral mesoderm into the area which will form the primary beating heart tube[GO:0003138]
XAO:0004185
@@ -47211,24 +47345,24 @@ MH: sexual subtypes should probably be logically defined based on sexual process
UBERON:0004140
primary heart field
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+
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GO:0003128
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+
https://orcid.org/0000-0003-3308-6245
@@ -47287,7 +47421,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
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An epithelial tube that will give rise to the mature heart.
the paired, longitudinal, endothelial-lined channels formed from the cardiogenic mesoderm in embryonic development; angiogenic cell clusters (aka angioblastic cords) located in a horse-shoe shape configuration in the cardiogenic plate coalesce to form the right and left endocardial heart tubes which then fuse in cephalo-caudal direction to form a single primitive heart tube.
AAO:0010411
@@ -47307,14 +47441,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
heart tube
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+
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ZFA-modified
@@ -47518,7 +47652,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
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@@ -47628,7 +47761,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
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@@ -47720,7 +47852,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
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@@ -47797,7 +47928,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
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@@ -47926,7 +48056,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
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@@ -47934,7 +48063,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
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A specialized form of connective tissue in which the extracellular matrix is firm, providing the tissue with resilience, and/or mineralized and that functions in mechanical and structural support.[VSAO].
A specialized form of connective tissue in which the extracellular matrix is firm, providing the tissue with resilience, and/or mineralized and that functions in mechanical and structural support.[VSAO]
EMAPA:37744
@@ -47948,7 +48077,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
Four classes of mineralized tissues are found in vertebrates: bone, cartilage, dentine, and enamel. We think of cartilage and bone as skeletal tissues and of enamel and dentine as dental tissues, but enamel and dentine arose evolutionarily together with bone as skeletal tissues in the dermal skeleton (exoskeleton) of early vertebrates. Scales and teeth of sharks are examples of dermal skeletal elements that are still composed of the three ancient components-enamel, dentine, and bone. Cartilage, on the other hand, provided the basis for the second vertebrate skeletal system, the endoskeleton (Smith and Hall, 1990; Hall, 1998a,b). some invertebrate skeletal tissues have surprisingly bone-like features. Examples include chondrocytes interconnected by cell processes in cephalopod cartilages (Cole and Hall, 2004a,b), and the calcium phosphate layer in the shells of brachiopods (Rodland et al., 2003). However, neither bone nor mineralized cartilage have been found in invertebrates. Editors notes: TODO - develops_from
skeletal tissue
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@@ -47961,7 +48090,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
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2012-08-14
VSAO:0000015
VSAO
@@ -48000,7 +48129,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
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+
Organ consisting of skeletal tissue. Encompasses whole bones, fused bones, cartilaginious elements, teeth, dermal denticles.
Organ entity that is typically involved in mechanical support and may have different skeletal tissue compositions at different stages.[VSAO]
Organ entity that may have different tissue compositions at different stages and is typically involved in mechanical support.[TAO]
@@ -48016,14 +48145,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
skeletal element
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VSAO
@@ -48068,7 +48197,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
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@@ -48107,14 +48236,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
UBERON:0004770
articular system
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FMA
@@ -48633,7 +48762,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -48873,7 +49001,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
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+
Mesenchyme that is part of a developing trunk.
EFO:0003485
EHDAA2:0002092
@@ -48889,14 +49017,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
trunk mesenchyme
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+
-
+
EHDAA2
@@ -49007,7 +49135,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
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Multi-tissue structure that arises from the heart rudiment and will become the heart tube.
EHDAA2:0001512
EHDAA:424
@@ -49025,14 +49153,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
primitive heart tube
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+
-
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ZFA
@@ -49200,7 +49328,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
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A delimited region of dense mesenchyme within looser mesenchyme.
AEO:0000148
EHDAA2_RETIRED:0003148
@@ -49210,7 +49338,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
UBERON:0005856
developing mesenchymal condensation
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+
@@ -49229,7 +49357,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
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AEO-modified-relation
@@ -49250,7 +49378,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
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@@ -49335,7 +49462,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
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The notochordal plate is the dorsal part of the notochordal process when the ventral portion breaks down. It is continuous laterally with the endoderm that composes the roof of the primitive foregut and is in contact dorsally with the neural tube. The folding off of the notochordal plate gives rise to the notochord.
TODO - check ordering; awaiting confirmation from JB
The notochordal plate is the dorsal part of the notochordal process when the ventral portion breaks down. It is continuous laterally with the endoderm that composes the roof of the primitive foregut and is in contact dorsally with the neural tube. The folding off of the notochordal plate gives rise to the notochord. [Carson_JL, Dehart_DB, Developmental_Dynamics_(1994)_201:_260-278, Gesteland_K_and_Schoenwolf_GC, Inagaki_T, Morphogenesis_of_the_murine_node_and_notochordal_plate, The_prechordal_plate, Vrablic_T, see_Mueller_F_and_O'Rahilly_R, the_rostral_end_of_the_notochord_and_nearby_median_features_in_staged_human_embryos._Cells_Tissues_Organs_(2003)_173:_1-20_and_Sulik_K][VHOG]
@@ -49350,7 +49477,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
notochordal plate
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@@ -49363,7 +49490,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
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EHDAA2
@@ -49393,7 +49520,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -49401,7 +49527,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
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+
A midline cellular cord formed from the migration of mesenchymal cells from the primitive knot.
EHDAA2:0001279
EHDAA:224
@@ -49418,14 +49544,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
The notochordal process grows cranially until it reaches the prechordal plate, the future site of the mouth. In this area the ectoderm is attached directly to the endoderm without intervening mesoderm. This area is known as the oropharyngeal membrane, and it will break down to become the mouth. At the other end of the primitive streak the ectoderm is also fused directly to the endoderm; this is known as the cloacal membrane (proctodeum), or primordial anus.
notochordal process
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+
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+
EHDAA2
@@ -49645,7 +49771,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -49857,7 +49982,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -49944,7 +50068,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -50171,7 +50294,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
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+
A hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood or analogs[GO,modified].
note we reserve the subclass 'heart' from the vertebrate multi-chambered heart. 'The first heart-like organ is believed to have appeared 500my ago in an ancestral bilaterian'. Amniotes: four-chambered heart. Amphibians: two atria, one ventricle, pulmonary; fish: single atrium and ventricle; amphioxus: tubular, non-striated, closed, unidirectional; ascidians: tubular, striated, open, bidirectional; arthropods: tubular, open; C elegans: contractile pharynx; Cnideria: striated muscle cells associated with gastrodermis
SPD:0000130
@@ -50186,14 +50309,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
Gene notes: Bmp, Nkx, Gata
primary circulatory organ
-
+
-
+
GO uses blood circulation generically to include the haemolymphatic fluid of arthropods
@@ -50283,7 +50406,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
@@ -50300,14 +50423,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
presumptive segmental plate
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+
-
+
https://github.com/obophenotype/uberon/wiki/The-neural-crest
EDHAA2
@@ -50406,7 +50529,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
@@ -50432,7 +50555,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
presumptive paraxial mesoderm
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+
@@ -50448,7 +50571,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
https://github.com/obophenotype/uberon/issues/1277
@@ -50523,9 +50646,8 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
-
+
Mesenchyme with little extracellular matrix.
AEO:0000146
EHDAA2:0003146
@@ -50533,7 +50655,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
UBERON:0007524
dense mesenchyme tissue
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+
@@ -50546,7 +50668,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
AEO
@@ -50643,7 +50765,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
Anatomical system that consists of all blood and lymph vessels.
consider merging with vasculature
The cardiovascular and lymphatic systems, collectively[ncithesaurus:Vascular_System].
@@ -50660,14 +50782,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
vascular system
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+
-
+
MA
@@ -50793,7 +50915,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -50801,7 +50922,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
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+
@@ -50818,14 +50939,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
UBERON:0009142
entire embryonic mesenchyme
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+
-
+
EHDAA2
@@ -50881,7 +51002,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
EHDAA2:0002094
trunk and cervical paraxial mesenchyme
uberon
@@ -50889,14 +51010,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
UBERON:0009618
trunk paraxial mesoderm
-
+
-
+
EHDAA2
@@ -50918,7 +51039,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
EFO:0003704
TAO:0005041
ZFA:0005041
@@ -50928,14 +51049,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
anterior lateral plate mesoderm
-
+
-
+
ZFA
@@ -51043,7 +51164,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -51070,7 +51190,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
@@ -51090,14 +51210,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
UBERON:0010210
blood clot
-
+
-
+
BTO
@@ -51136,7 +51256,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -51163,7 +51282,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -51221,8 +51339,8 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
-
+
+
Anatomical cluster consisting of the skeletal elements (i.e. bone elements, cartilage elements, cartilage condensations) that are part of an individual subdivision of the organism. Excludes joints.
Anatomical cluster consisting of the skeletal elements that are part of the skeleton.[VSAO]
FMA:23879
@@ -51235,11 +51353,11 @@ MH: sexual subtypes should probably be logically defined based on sexual process
subdivision of skeleton
-
+
-
+
@@ -51252,13 +51370,13 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
UBERONREF:0000003
-
+
VSAO
@@ -51296,7 +51414,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -51335,9 +51452,8 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
-
+
Subdivision of the skeletal system which consists of the postcranial axial skeleton plus associated joints.
axial skeletal system
FMA:302077
@@ -51347,7 +51463,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
postcranial axial skeletal system
http://purl.obolibrary.org/obo/uberon/docs/The-axial-skeleton
-
+
@@ -51360,7 +51476,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
cjm
@@ -51625,7 +51741,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
@@ -51647,7 +51763,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
UBERON:0012429
hematopoietic tissue
-
+
@@ -51660,7 +51776,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
defitional
@@ -51928,7 +52044,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -52231,7 +52346,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
@@ -52254,7 +52369,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
UBERON:0016887
entire extraembryonic component
-
+
@@ -52267,7 +52382,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
AEO
@@ -52428,7 +52543,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -52493,6 +52607,196 @@ MH: sexual subtypes should probably be logically defined based on sexual process
+
+
+
+
+
+
+
+
+ example to be eventually removed
+ example to be eventually removed
+
+
+
+
+
+
+
+ failed exploratory term
+ The term was used in an attempt to structure part of the ontology but in retrospect failed to do a good job
+ Person:Alan Ruttenberg
+ failed exploratory term
+
+
+
+
+
+
+
+ metadata complete
+ Class has all its metadata, but is either not guaranteed to be in its final location in the asserted IS_A hierarchy or refers to another class that is not complete.
+ metadata complete
+
+
+
+
+
+
+
+ organizational term
+ Term created to ease viewing/sort terms for development purpose, and will not be included in a release
+ organizational term
+
+
+
+
+
+
+
+ ready for release
+ Class has undergone final review, is ready for use, and will be included in the next release. Any class lacking "ready_for_release" should be considered likely to change place in hierarchy, have its definition refined, or be obsoleted in the next release. Those classes deemed "ready_for_release" will also derived from a chain of ancestor classes that are also "ready_for_release."
+ ready for release
+
+
+
+
+
+
+
+ metadata incomplete
+ Class is being worked on; however, the metadata (including definition) are not complete or sufficiently clear to the branch editors.
+ metadata incomplete
+
+
+
+
+
+
+
+ uncurated
+ Nothing done yet beyond assigning a unique class ID and proposing a preferred term.
+ uncurated
+
+
+
+
+
+
+
+ pending final vetting
+ All definitions, placement in the asserted IS_A hierarchy and required minimal metadata are complete. The class is awaiting a final review by someone other than the term editor.
+ pending final vetting
+
+
+
+
+
+
+
+ placeholder removed
+ placeholder removed
+
+
+
+
+
+
+
+ terms merged
+ An editor note should explain what were the merged terms and the reason for the merge.
+ terms merged
+
+
+
+
+
+
+
+ term imported
+ This is to be used when the original term has been replaced by a term imported from an other ontology. An editor note should indicate what is the URI of the new term to use.
+ term imported
+
+
+
+
+
+
+
+ term split
+ This is to be used when a term has been split in two or more new terms. An editor note should indicate the reason for the split and indicate the URIs of the new terms created.
+ term split
+
+
+
+
+
+
+
+ universal
+ Hard to give a definition for. Intuitively a "natural kind" rather than a collection of any old things, which a class is able to be, formally. At the meta level, universals are defined as positives, are disjoint with their siblings, have single asserted parents.
+ Alan Ruttenberg
+ A Formal Theory of Substances, Qualities, and Universals, http://ontology.buffalo.edu/bfo/SQU.pdf
+ universal
+
+
+
+
+
+
+
+ defined class
+ A defined class is a class that is defined by a set of logically necessary and sufficient conditions but is not a universal
+ "definitions", in some readings, always are given by necessary and sufficient conditions. So one must be careful (and this is difficult sometimes) to distinguish between defined classes and universal.
+ Alan Ruttenberg
+ defined class
+
+
+
+
+
+
+
+ named class expression
+ A named class expression is a logical expression that is given a name. The name can be used in place of the expression.
+ named class expressions are used in order to have more concise logical definition but their extensions may not be interesting classes on their own. In languages such as OWL, with no provisions for macros, these show up as actuall classes. Tools may with to not show them as such, and to replace uses of the macros with their expansions
+ Alan Ruttenberg
+ named class expression
+
+
+
+
+
+
+
+ to be replaced with external ontology term
+ Terms with this status should eventually replaced with a term from another ontology.
+ Alan Ruttenberg
+ group:OBI
+ to be replaced with external ontology term
+
+
+
+
+
+
+
+ requires discussion
+ A term that is metadata complete, has been reviewed, and problems have been identified that require discussion before release. Such a term requires editor note(s) to identify the outstanding issues.
+ Alan Ruttenberg
+ group:OBI
+ requires discussion
+
+
+
+
+
+
+
+
+
@@ -68,7 +75,34 @@
+ definition
+
+ The official definition, explaining the meaning of a class or property. Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions.
+ 2012-04-05:
+Barry Smith
+
+The official OBI definition, explaining the meaning of a class or property: 'Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions' is terrible.
+
+Can you fix to something like:
+
+A statement of necessary and sufficient conditions explaining the meaning of an expression referring to a class or property.
+
+Alan Ruttenberg
+
+Your proposed definition is a reasonable candidate, except that it is very common that necessary and sufficient conditions are not given. Mostly they are necessary, occasionally they are necessary and sufficient or just sufficient. Often they use terms that are not themselves defined and so they effectively can't be evaluated by those criteria.
+
+On the specifics of the proposed definition:
+
+We don't have definitions of 'meaning' or 'expression' or 'property'. For 'reference' in the intended sense I think we use the term 'denotation'. For 'expression', I think we you mean symbol, or identifier. For 'meaning' it differs for class and property. For class we want documentation that let's the intended reader determine whether an entity is instance of the class, or not. For property we want documentation that let's the intended reader determine, given a pair of potential relata, whether the assertion that the relation holds is true. The 'intended reader' part suggests that we also specify who, we expect, would be able to understand the definition, and also generalizes over human and computer reader to include textual and logical definition.
+
+Personally, I am more comfortable weakening definition to documentation, with instructions as to what is desirable.
+
+We also have the outstanding issue of how to aim different definitions to different audiences. A clinical audience reading chebi wants a different sort of definition documentation/definition from a chemistry trained audience, and similarly there is a need for a definition that is adequate for an ontologist to work with.
+ PERSON:Daniel Schober
+ GROUP:OBI:<http://purl.obolibrary.org/obo/obi>
+
definition
+ definition
@@ -76,12 +110,19 @@
+ editor note
+
+ An administrative note intended for its editor. It may not be included in the publication version of the ontology, so it should contain nothing necessary for end users to understand the ontology.
+ PERSON:Daniel Schober
+ GROUP:OBI:<http://purl.obofoundry.org/obo/obi>
IAO:0000116
uberon
editor_note
true
editor_note
+
editor note
+ editor note
@@ -106,7 +147,13 @@
-
+
+ has obsolescence reason
+ Relates an annotation property to an obsolescence reason. The values of obsolescence reasons come from a list of predefined terms, instances of the class obsolescence reason specification.
+ PERSON:Alan Ruttenberg
+ PERSON:Melanie Courtot
+ has obsolescence reason
+
@@ -119,6 +166,12 @@
+ term tracker item
+ the URI for an OBI Terms ticket at sourceforge, such as https://sourceforge.net/p/obi/obi-terms/772/
+
+ An IRI or similar locator for a request or discussion of an ontology term.
+ Person: Jie Zheng, Chris Stoeckert, Alan Ruttenberg
+ Person: Jie Zheng, Chris Stoeckert, Alan Ruttenberg
IAO:0000233
external
uberon
@@ -126,7 +179,9 @@
true
true
term_tracker_item
+ The 'tracker item' can associate a tracker with a specific ontology term.
term tracker item
+ term tracker item
@@ -134,7 +189,15 @@
+ expand expression to
+ ObjectProperty: RO_0002104
+Label: has plasma membrane part
+Annotations: IAO_0000424 "http://purl.obolibrary.org/obo/BFO_0000051 some (http://purl.org/obo/owl/GO#GO_0005886 and http://purl.obolibrary.org/obo/BFO_0000051 some ?Y)"
+
+ A macro expansion tag applied to an object property (or possibly a data property) which can be used by a macro-expansion engine to generate more complex expressions from simpler ones
+ Chris Mungall
expand expression to
+ expand expression to
@@ -166,12 +229,16 @@
+ has ontology root term
+ Ontology annotation property. Relates an ontology to a term that is a designated root term of the ontology. Display tools like OLS can use terms annotated with this property as the starting point for rendering the ontology class hierarchy. There can be more than one root.
+ Nicolas Matentzoglu
IAO:0000700
uberon
has_ontology_root_term
true
has_ontology_root_term
has ontology root term
+ has ontology root term
preferred_root
@@ -186,7 +253,14 @@
+ term replaced by
+
+ Use on obsolete terms, relating the term to another term that can be used as a substitute
+ Person:Alan Ruttenberg
+ Person:Alan Ruttenberg
+ Add as annotation triples in the granting ontology
term replaced by
+ term replaced by
@@ -512,6 +586,12 @@ WHERE {
+
+
+
+
+
+
@@ -1060,6 +1140,7 @@ WHERE {
+ a mis-spelling that is in common use and thus recorded
@@ -1876,6 +1957,12 @@ WHERE {
+
+
+
+
+
+
+
+
+ This document is about information artifacts and their representations
+
+ A (currently) primitive relation that relates an information artifact to an entity.
+ 7/6/2009 Alan Ruttenberg. Following discussion with Jonathan Rees, and introduction of "mentions" relation. Weaken the is_about relationship to be primitive.
+
+We will try to build it back up by elaborating the various subproperties that are more precisely defined.
+
+Some currently missing phenomena that should be considered "about" are predications - "The only person who knows the answer is sitting beside me" , Allegory, Satire, and other literary forms that can be topical without explicitly mentioning the topic.
+ person:Alan Ruttenberg
+ Smith, Ceusters, Ruttenberg, 2000 years of philosophy
+ is about
+
+
+
+
@@ -2743,6 +2850,7 @@ range: spatial region or site (immaterial continuant)
located_in
located in
located in
+ https://wiki.geneontology.org/Located_in
@@ -2810,8 +2918,8 @@ range: spatial region or site (immaterial continuant)
-
-
+
+
@@ -2885,7 +2993,7 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
A 'has regulatory component activity' B if A and B are GO molecular functions (GO_0003674), A has_component B and A is regulated by B.
- dos
+
2017-05-24T09:30:46Z
RO:0002013
external
@@ -2902,7 +3010,7 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
A relationship that holds between a GO molecular function and a component of that molecular function that negatively regulates the activity of the whole. More formally, A 'has regulatory component activity' B iff :A and B are GO molecular functions (GO_0003674), A has_component B and A is negatively regulated by B.
- dos
+
2017-05-24T09:31:01Z
RO:0002014
external
@@ -2920,7 +3028,7 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
A relationship that holds between a GO molecular function and a component of that molecular function that positively regulates the activity of the whole. More formally, A 'has regulatory component activity' B iff :A and B are GO molecular functions (GO_0003674), A has_component B and A is positively regulated by B.
- dos
+
2017-05-24T09:31:17Z
By convention GO molecular functions are classified by their effector function and internal regulatory functions are treated as components. So, for example calmodulin has a protein binding activity that has positive regulatory component activity calcium binding activity. Receptor tyrosine kinase activity is a tyrosine kinase activity that has positive regulatory component 'ligand binding'.
has positive regulatory component activity
@@ -2932,7 +3040,7 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
- dos
+
2017-05-24T09:44:33Z
A 'has component activity' B if A is A and B are molecular functions (GO_0003674) and A has_component B.
has component activity
@@ -2947,7 +3055,7 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
w 'has process component' p if p and w are processes, w 'has part' p and w is such that it can be directly disassembled into into n parts p, p2, p3, ..., pn, where these parts are of similar type.
- dos
+
2017-05-24T09:49:21Z
has component process
@@ -2959,7 +3067,7 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
A relationship between a process and a barrier, where the process occurs in a region spanning the barrier. For cellular processes the barrier is typically a membrane. Examples include transport across a membrane and membrane depolarization.
- dos
+
2017-07-20T17:19:37Z
occurs across
@@ -2971,7 +3079,7 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
- dos
+
2017-09-17T13:52:24Z
Process(P2) is directly regulated by process(P1) iff: P1 regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding regulates the kinase activity (P2) of protein B then P1 directly regulates P2.
directly regulated by
@@ -2980,7 +3088,7 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
Process(P2) is directly regulated by process(P1) iff: P1 regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding regulates the kinase activity (P2) of protein B then P1 directly regulates P2.
- GOC:dos
+
@@ -2991,7 +3099,7 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
Process(P2) is directly negatively regulated by process(P1) iff: P1 negatively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding negatively regulates the kinase activity (P2) of protein B then P2 directly negatively regulated by P1.
- dos
+
2017-09-17T13:52:38Z
directly negatively regulated by
@@ -2999,7 +3107,7 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
Process(P2) is directly negatively regulated by process(P1) iff: P1 negatively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding negatively regulates the kinase activity (P2) of protein B then P2 directly negatively regulated by P1.
- GOC:dos
+
@@ -3010,7 +3118,7 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
Process(P2) is directly postively regulated by process(P1) iff: P1 positively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding positively regulates the kinase activity (P2) of protein B then P2 is directly postively regulated by P1.
- dos
+
2017-09-17T13:52:47Z
directly positively regulated by
@@ -3018,7 +3126,7 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
Process(P2) is directly postively regulated by process(P1) iff: P1 positively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding positively regulates the kinase activity (P2) of protein B then P2 is directly postively regulated by P1.
- GOC:dos
+
@@ -3029,7 +3137,7 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
A 'has effector activity' B if A and B are GO molecular functions (GO_0003674), A 'has component activity' B and B is the effector (output function) of B. Each compound function has only one effector activity.
- dos
+
2017-09-22T14:14:36Z
This relation is designed for constructing compound molecular functions, typically in combination with one or more regulatory component activity relations.
has effector activity
@@ -3038,7 +3146,7 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
A 'has effector activity' B if A and B are GO molecular functions (GO_0003674), A 'has component activity' B and B is the effector (output function) of B. Each compound function has only one effector activity.
- GOC:dos
+
@@ -3060,7 +3168,9 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
+
+ x simultaneous with y iff ω(x) = ω(y) and ω(α ) = ω(α), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point and '=' indicates the same instance in time.
David Osumi-Sutherland
RO:0002082
@@ -3141,14 +3251,14 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
-
+
+ Relation between a neuron and a material anatomical entity that its soma is part of.
Relation between a neuron and an anatomical structure that its soma is part of.
- Relation between a neuron and an anatomical structure that its soma is part of.
<http://purl.obolibrary.org/obo/BFO_0000051> some (
<http://purl.obolibrary.org/obo/GO_0043025> and <http://purl.obolibrary.org/obo/BFO_0000050> some ?Y)
@@ -3174,7 +3284,7 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
-
+
Relation between a neuron and the neuron projection bundle it fasciculates with. FOL: x fasciculates_with y iff: exists some 'neuron ; CL_0000540'(x), some 'neuron projection bundle ; CARO_0001001'(y), some 'neuron projection ; GO_0043005'(np), np part_of x AND np overlaps y AND np aligned_with y
relationship between a neuron and a neuron projection bundle (e.g.- tract or nerve bundle) that one or more of its projections travels through.
@@ -3287,8 +3397,8 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
-
-
+
+
Every B cell[CL_0000236] has plasma membrane part some immunoglobulin complex[GO_0019814]
Holds between a cell c and a protein complex or protein p if and only if that cell has as part a plasma_membrane[GO:0005886], and that plasma membrane has p as part.
@@ -3488,7 +3598,7 @@ N1 SubclassOf (
-
+
@@ -3537,7 +3647,7 @@ N1 SubclassOf (
-
+
@@ -3639,7 +3749,6 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.
-
@@ -3816,8 +3925,8 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.
-
-
+
+
@@ -3949,7 +4058,7 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.
-
+
@@ -3971,16 +4080,16 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.
-
+
-
+
@@ -4341,7 +4450,7 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.
-
+
@@ -4479,6 +4588,7 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.has_input
has input
has input
+ https://wiki.geneontology.org/Has_input
@@ -4506,6 +4616,7 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.has_output
has output
has output
+ https://wiki.geneontology.org/Has_output
@@ -4515,8 +4626,8 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.
-
-
+
+
@@ -4558,8 +4669,8 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.
-
-
+
+
t1 induced_by t2 if there is a process of developmental induction (GO:0031128) with t1 and t2 as interacting participants. t2 causes t1 to change its fate from a precursor material anatomical entity type T to T', where T' develops_from T
@@ -4641,7 +4752,7 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.affects
acts upstream of or within
-
+ https://wiki.geneontology.org/Acts_upstream_of_or_within
@@ -4698,7 +4809,7 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.
- Inverse of 'expressed in'
+ y expresses x if and only if there is a gene expression process (GO:0010467) that occurs in y, and one of the following holds: (i) x is a gene, and x is transcribed into a transcript as part of the gene expression process (ii) x is a transcript, and x was transcribed from a gene as part of the gene expression process (iii) x is a mature gene product (protein or RNA), and x was translated or otherwise processed from a transcript that was transcribed as part of the gene expression process.
expresses
@@ -4710,7 +4821,7 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.
-
+
p results in the developmental progression of s iff p is a developmental process and s is an anatomical entity and p causes s to undergo a change in state at some point along its natural developmental cycle (this cycle starts with its formation, through the mature structure, and ends with its loss).
This property and its subproperties are being used primarily for the definition of GO developmental processes. The property hierarchy mirrors the core GO hierarchy. In future we may be able to make do with a more minimal set of properties, but due to the way GO is currently structured we require highly specific relations to avoid incorrect entailments. To avoid this, the corresponding genus terms in GO should be declared mutually disjoint.
@@ -4837,6 +4948,7 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.causally_upstream_of,_positive_effect
holds between x and y if and only if x is causally upstream of y and the progression of x increases the frequency, rate or extent of y
causally upstream of, positive effect
+
@@ -4856,6 +4968,7 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.
causally_upstream_of,_negative_effect
causally upstream of, negative effect
+
@@ -4898,7 +5011,7 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.
-
+
an annotation of gene X to cell differentiation with results_in_maturation_of CL:0000057 (fibroblast) means that at the end of the process the input cell that did not have features of a fibroblast, now has the features of a fibroblast.
The relationship that links a specified entity with the process that results in an unspecified entity acquiring the features and characteristics of the specified entity
@@ -4974,6 +5087,7 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.This relation differs from the parent relation 'capable of' in that the parent is weaker and only expresses a capability that may not be actually realized, whereas this relation is always realized.
enables
+ https://wiki.geneontology.org/Enables
@@ -5050,7 +5164,7 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.actively involved in
enables part of
involved in
-
+ https://wiki.geneontology.org/Involved_in
@@ -5085,6 +5199,7 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.
enabled by
+ https://wiki.geneontology.org/Enabled_by
@@ -5389,7 +5504,7 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.
-
+
m has_muscle_origin s iff m is attached_to s, and it is the case that when m contracts, s does not move. The site of the origin tends to be more proximal and have greater mass than what the other end attaches to.
Wikipedia:Insertion_(anatomy)
@@ -5404,7 +5519,7 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.
-
+
We need to import uberon muscle to create a stricter domain constraint
@@ -5415,7 +5530,7 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.
-
+
m has_muscle_insertion s iff m is attaches_to s, and it is the case that when m contracts, s moves. Insertions are usually connections of muscle via tendon to bone.
Wikipedia:Insertion_(anatomy)
@@ -5430,7 +5545,7 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.
-
+
We need to import uberon muscle into RO to use as a stricter domain constraint
@@ -5535,8 +5650,8 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.
-
-
+
+
x has developmental potential involving y iff x is capable of a developmental process with output y. y may be the successor of x, or may be a different structure in the vicinity (as for example in the case of developmental induction).
@@ -5667,6 +5782,7 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.indirectly activates
indirectly positively regulates
+ https://wiki.geneontology.org/Indirectly_positively_regulates
@@ -5694,6 +5810,7 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.indirectly inhibits
indirectly negatively regulates
+ https://wiki.geneontology.org/Indirectly_negatively_regulates
@@ -5897,6 +6014,7 @@ Each of these 3 primitives can be composed to yield a cross-product of different
enables activity in
is active in
+ https://wiki.geneontology.org/Is_active_in
@@ -5911,8 +6029,8 @@ Each of these 3 primitives can be composed to yield a cross-product of different
c executes activity in d if and only if c enables p and p occurs_in d. Assuming no action at a distance by gene products, if a gene product enables (is capable of) a process that occurs in some structure, it must have at least some part in that structure.
- GOC:cjm
- GOC:dos
+
+
@@ -6423,9 +6541,9 @@ For example, A and B may be gene products and binding of B by A positively regul
-
+
-
+
Forelimb SubClassOf has_skeleton some 'Forelimb skeleton'
A relation between a segment or subdivision of an organism and the maximal subdivision of material entities that provides structural support for that segment or subdivision.
@@ -6441,7 +6559,7 @@ For example, A and B may be gene products and binding of B by A positively regul
-
+
This should be to a more restricted class, but not the Uberon class may be too restricted since it is a composition-based definition of skeleton rather than functional.
@@ -6531,8 +6649,8 @@ For example, A and B may be gene products and binding of B by A positively regul
-
-
+
+
A relation that holds between elements of a musculoskeletal system or its analogs.
Do not use this relation directly. It is ended as a grouping for a diverse set of relations, all involving the biomechanical processes.
@@ -6603,7 +6721,7 @@ For example, A and B may be gene products and binding of B by A positively regul
x lumen_of y iff x is the space or substance that is part of y and does not cross any of the inner membranes or boundaries of y that is maximal with respect to the volume of the convex hull.
- GOC:cjm
+
RO:0002571
uberon
lumen_of
@@ -6635,8 +6753,8 @@ For example, A and B may be gene products and binding of B by A positively regul
-
-
+
+
inverse of has skeleton
RO:0002576
@@ -6821,6 +6939,16 @@ For example, A and B may be gene products and binding of B by A positively regul
+
+
+
+ A relationship that holds between two entities, where the entities exhibit a statistical dependence relationship. The entities may be statistical variables, or they may be other kinds of entities such as diseases, chemical entities or processes.
+ Groups both positive and negative correlation
+ correlated with
+
+
+
+
@@ -6838,6 +6966,7 @@ For example, A and B may be gene products and binding of B by A positively regul
directly_positively_regulates
directly positively regulates
+ https://wiki.geneontology.org/Directly_positively_regulates
@@ -6859,6 +6988,7 @@ For example, A and B may be gene products and binding of B by A positively regul
directly_negatively_regulates
directly negatively regulates
+ https://wiki.geneontology.org/Directly_negatively_regulates
@@ -6947,7 +7077,7 @@ For example, A and B may be gene products and binding of B by A positively regul
p has primary output c if (a) p has output c and (b) the goal of process is to modify, produce, or transform c.
- GOC:cjm
+
GOC:dph
GOC:kva
GOC:pt
@@ -6975,7 +7105,7 @@ For example, A and B may be gene products and binding of B by A positively regul
p has primary input c if (a) p has input c and (b) the goal of process is to modify, consume, or transform c.
- GOC:cjm
+
GOC:dph
GOC:kva
GOC:pt
@@ -7013,7 +7143,7 @@ For example, A and B may be gene products and binding of B by A positively regul
2018-01-26T23:49:30Z
acts upstream of or within, positive effect
-
+ https://wiki.geneontology.org/Acts_upstream_of_or_within,_positive_effect
@@ -7031,6 +7161,7 @@ For example, A and B may be gene products and binding of B by A positively regul
2018-01-26T23:49:51Z
acts upstream of or within, negative effect
+ https://wiki.geneontology.org/Acts_upstream_of_or_within,_negative_effect
@@ -7050,7 +7181,7 @@ For example, A and B may be gene products and binding of B by A positively regul
2018-01-26T23:53:14Z
acts upstream of, positive effect
-
+ https://wiki.geneontology.org/Acts_upstream_of,_positive_effect
@@ -7070,7 +7201,7 @@ For example, A and B may be gene products and binding of B by A positively regul
2018-01-26T23:53:22Z
acts upstream of, negative effect
-
+ https://wiki.geneontology.org/Acts_upstream_of,_negative_effect
@@ -7083,6 +7214,7 @@ For example, A and B may be gene products and binding of B by A positively regul
2018-03-13T23:55:05Z
causally upstream of or within, negative effect
+ https://wiki.geneontology.org/Causally_upstream_of_or_within,_negative_effect
@@ -7095,6 +7227,7 @@ For example, A and B may be gene products and binding of B by A positively regul
2018-03-13T23:55:19Z
causally upstream of or within, positive effect
+
@@ -7117,7 +7250,7 @@ For example, A and B may be gene products and binding of B by A positively regul
p acts on population of c iff c' is a collection, has members of type c, and p has participant c
- pg
+
2020-06-08T17:21:33Z
RO:0012003
external
@@ -7136,7 +7269,7 @@ For example, A and B may be gene products and binding of B by A positively regul
- pg
+
2021-02-26T07:28:29Z
RO:0012008
external
@@ -7156,7 +7289,7 @@ For example, A and B may be gene products and binding of B by A positively regul
p is indirectly causally upstream of q iff p is causally upstream of q and there exists some process r such that p is causally upstream of r and r is causally upstream of q.
- pg
+
2022-09-26T06:07:17Z
indirectly causally upstream of
@@ -7169,7 +7302,7 @@ For example, A and B may be gene products and binding of B by A positively regul
p indirectly regulates q iff p is indirectly causally upstream of q and p regulates q.
- pg
+
2022-09-26T06:08:01Z
indirectly regulates
@@ -7185,7 +7318,7 @@ For example, A and B may be gene products and binding of B by A positively regul
A relationship between a neuron and a region, where the neuron has a functionally relevant number of input and/or output synapses in that region.
-
+
2020-07-17T09:26:52Z
has synaptic input or output in
has synaptic IO in region
@@ -7203,7 +7336,7 @@ For example, A and B may be gene products and binding of B by A positively regul
Relation between a sensory neuron and some structure in which it receives sensory input via a sensory dendrite.
-
+
2020-07-20T12:10:09Z
has sensory dendrite location
has sensory terminal in
@@ -7299,8 +7432,8 @@ For example, A and B may be gene products and binding of B by A positively regul
'Ly-76 high positive erythrocyte' equivalent to 'enucleate erythrocyte' and (has_high_plasma_membrane_amount some 'lymphocyte antigen 76 (mouse)')
A relation between a cell and molecule or complex such that every instance of the cell has a high number of instances of that molecule expressed on the cell surface.
-
-
+
+
has high plasma membrane amount
@@ -7319,8 +7452,8 @@ For example, A and B may be gene products and binding of B by A positively regul
'DN2b thymocyte' equivalent to 'DN2 thymocyte' and (has_low_plasma_membrane_amount some 'mast/stem cell growth factor receptor')
A relation between a cell and molecule or complex such that every instance of the cell has a low number of instances of that molecule expressed on the cell surface.
-
-
+
+
has low plasma membrane amount
@@ -7352,6 +7485,20 @@ For example, A and B may be gene products and binding of B by A positively regul
+
+
+
+
+
+
+ A relation between entities in which one increases or decreases as the other does the same.
+ directly correlated with
+
+ positively correlated with
+
+
+
+
@@ -7823,7 +7970,8 @@ For example, A and B may be gene products and binding of B by A positively regul
- A continuant that is a bearer of quality and realizable entity entities, in which other entities inhere and which itself cannot inhere in anything.
+ b is an independent continuant = Def. b is a continuant which is such that there is no c and no t such that b s-depends_on c at t. (axiom label in BFO2 Reference: [017-002])
+ A continuant that is a bearer of quality and realizable entity entities, in which other entities inhere and which itself cannot inhere in anything.
independent continuant
@@ -7833,7 +7981,8 @@ For example, A and B may be gene products and binding of B by A positively regul
- An occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t.
+ p is a process = Def. p is an occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t. (axiom label in BFO2 Reference: [083-003])
+ An occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t.
process
@@ -7849,7 +7998,8 @@ For example, A and B may be gene products and binding of B by A positively regul
- A continuant that inheres in or is borne by other entities. Every instance of A requires some specific instance of B which must always be the same.
+ b is a specifically dependent continuant = Def. b is a continuant & there is some independent continuant c which is not a spatial region and which is such that b s-depends_on c at every time t during the course of b’s existence. (axiom label in BFO2 Reference: [050-003])
+ A continuant that inheres in or is borne by other entities. Every instance of A requires some specific instance of B which must always be the same.
specifically dependent continuant
@@ -7988,104 +8138,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
-
-
-
-
-
-
-
- An anatomical structure that has as its parts a maximally connected cell compartment surrounded by a plasma membrane.
- CL:0000000
- GO:0005623
- CARO:0000013
- deprecate and replace with CL or GO term?
- cell
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
- Anatomical structure that is part of a cell and that has a granularity level equal to that of a protein complex or higher.
- cell component
- CARO:0000014
- This is declared equivalent with GO:0044464. The definition should be co-ordinated with GO. We could obsolete the CARO class and just use the GO class.
- cell part
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
- 2
-
-
-
-
-
-
- A structure consisting of multiple cell components but which is not itself a cell and does not have (complete) cells as a part.
- multi-cell-component structure
- CARO:0001000
-
- Examples: a bundle of neuron projections in the brain; a region neuropil in an arthropod central nervous system; a region of cortex (preikaryal rind) in an arthropod brain.
- multi-cell-part structure
-
-
-
-
-
-
-
-
-
-
-
-
-
-
- A fasciculated bundle of neuron projections (GO:0043005), largely or completely lacking synapses.
- nerve fiber bundle
- CARO:0001001
- neuron projection bundle
-
-
-
-
- nerve fiber bundle
- EXACT
-
-
-
-
@@ -8121,7 +8173,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
@@ -8137,7 +8189,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
multicellular anatomical structure
-
+
@@ -8149,7 +8201,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
There is a cost to burying this in PATO. We lose that we could relax the cardinality assertion to subClassOf has_part some cell. I'm sure having this axiom inherited would come in handy. DOS
@@ -8170,34 +8222,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
-
-
-
-
- An anatomical structure consisting of one or more cells.
-
- 2018-09-28T14:20:19Z
- cellular anatomical structure
-
-
-
-
-
-
-
-
-
-
-
-
-
-
- With a reflexive part_of relation this might safely be defined as 'anatomical structure' that has_part some cell
-
-
-
-
@@ -8438,7 +8462,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -9002,7 +9025,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -9215,7 +9237,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -9356,7 +9377,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -9435,6 +9455,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
CALOHA:TS-2027
FMA:54538
macrogliocyte
+ macroglia
macroglial cell
@@ -9444,6 +9465,13 @@ MH: sexual subtypes should probably be logically defined based on sexual process
GOC:tfm
ISBN:0721662544
+
+
+
+ macroglia
+ doi:10.1152/physrev.2001.81.2.871
+
+
@@ -9651,7 +9679,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -9761,7 +9788,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -10385,7 +10411,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -10427,7 +10452,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -10784,7 +10808,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -10965,7 +10988,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -11056,7 +11078,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -11559,7 +11580,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -11674,7 +11694,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -11700,6 +11719,8 @@ MH: sexual subtypes should probably be logically defined based on sexual process
BTO:0004044
FMA:67766
amacrine neuron
+ AC
+ ACs
amacrine cell
@@ -11712,6 +11733,21 @@ MH: sexual subtypes should probably be logically defined based on sexual process
MESH:D025042
WikipediaVersioned:Amacrine_cell&oldid=1023572246
+
+
+
+ AC
+ doi:10.1038/s41598-020-66092-9
+
+
+
+
+
+ ACs
+ doi:10.1038/s41598-020-66092-9
+
+
+
@@ -11737,7 +11773,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -11805,6 +11840,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
BTO:0001036
CALOHA:TS-0866
FMA:67748
+ cone
retinal cone cell
@@ -11814,6 +11850,12 @@ MH: sexual subtypes should probably be logically defined based on sexual process
One of the two photoreceptor cell types in the vertebrate retina. In cones the photopigment is in invaginations of the cell membrane of the outer segment. Cones are less sensitive to light than rods, but they provide vision with higher spatial and temporal acuity, and the combination of signals from cones with different pigments allows color vision.
MESH:D017949
+
+
+
+ cone
+ doi:10.1038/s41598-020-66092-9
+
@@ -11879,6 +11921,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
BTO:0001024
CALOHA:TS-0870
FMA:67747
+ rod
retinal rod cell
@@ -11888,6 +11931,12 @@ MH: sexual subtypes should probably be logically defined based on sexual process
One of the two photoreceptor cell types of the vertebrate retina. In rods the photopigment is in stacks of membranous disks separate from the outer cell membrane. Rods are more sensitive to light than cones, but rod mediated vision has less spatial and temporal resolution than cone vision.
MESH:D017948
+
+
+
+ rod
+ doi:10.1038/s41598-020-66092-9
+
@@ -11905,6 +11954,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
Astrocyte-like radial glial cell that extends vertically throughout the retina, with the nucleus are usually in the middle of the inner nuclear layer.
BTO:0003064
+ Muller cell
Muller glia
Müller cell
@@ -11918,6 +11968,13 @@ MH: sexual subtypes should probably be logically defined based on sexual process
GOC:NV
PMID:21911394
+
+
+
+ Muller cell
+ doi:10.21769/BioProtoc.4179
+
+
@@ -11967,7 +12024,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -12115,9 +12171,10 @@ radial glial cells acting as neural progenitors throughout life.
BTO:0001800
FMA:67765
MESH:D012165
- RGC
gangliocyte
ganglion cell of retina
+ RGC
+ RGCs
retinal ganglion cell
@@ -12128,13 +12185,27 @@ radial glial cells acting as neural progenitors throughout life.
The set of neurons that receives neural inputs via bipolar, horizontal and amacrine cells. The axons of these cells make up the optic nerve.
GOC:dph
+
+
+
+ RGC
+ doi:10.1038/s41598-020-66092-9
+
+
+
+
+
+ RGCs
+ doi:10.1038/s41598-020-66092-9
+
+
+
-
@@ -12146,6 +12217,8 @@ radial glial cells acting as neural progenitors throughout life.
BTO:0004120
horizontal cell
+ HC
+ HCs
retina horizontal cell
@@ -12156,6 +12229,21 @@ radial glial cells acting as neural progenitors throughout life.
A neuron that laterally connects other neurons in the inner nuclear layer of the retina.
ISBN:0195088433
+
+
+
+ HC
+ doi:10.1038/s41598-020-66092-9
+
+
+
+
+
+ HCs
+ doi:10.1038/s41598-020-66092-9
+
+
+
@@ -12168,12 +12256,11 @@ radial glial cells acting as neural progenitors throughout life.
-
+
-
@@ -12181,7 +12268,7 @@ radial glial cells acting as neural progenitors throughout life.
-
+
@@ -12202,6 +12289,9 @@ radial glial cells acting as neural progenitors throughout life.
A bipolar neuron found in the retina and having connections with photoreceptors cells and neurons in the inner plexiform layer.
+ BC
+ BCs
+ BPs
retinal bipolar neuron
@@ -12212,6 +12302,29 @@ radial glial cells acting as neural progenitors throughout life.
A bipolar neuron found in the retina and having connections with photoreceptors cells and neurons in the inner plexiform layer.
PMID:14689473
+
+
+
+ BC
+ doi:10.1038/s41598-020-66092-9
+
+
+
+
+
+ BCs
+ doi:10.1038/s41598-020-66092-9
+
+
+
+
+
+
+ BPs
+ GSE137537
+
+
+
@@ -12229,7 +12342,6 @@ radial glial cells acting as neural progenitors throughout life.
-
@@ -12536,7 +12648,6 @@ radial glial cells acting as neural progenitors throughout life.
-
@@ -12743,7 +12854,6 @@ radial glial cells acting as neural progenitors throughout life.
-
@@ -12788,7 +12898,6 @@ radial glial cells acting as neural progenitors throughout life.
-
@@ -12834,7 +12943,6 @@ radial glial cells acting as neural progenitors throughout life.
-
@@ -12873,7 +12981,6 @@ radial glial cells acting as neural progenitors throughout life.
-
@@ -13530,7 +13637,6 @@ radial glial cells acting as neural progenitors throughout life.
-
@@ -13568,7 +13674,6 @@ radial glial cells acting as neural progenitors throughout life.
-
@@ -13598,7 +13703,6 @@ radial glial cells acting as neural progenitors throughout life.
-
@@ -13795,7 +13899,6 @@ radial glial cells acting as neural progenitors throughout life.
-
@@ -13853,7 +13956,6 @@ radial glial cells acting as neural progenitors throughout life.
-
@@ -13878,7 +13980,6 @@ radial glial cells acting as neural progenitors throughout life.
-
@@ -15221,32 +15322,32 @@ plexiform layer.
+
-
A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures.
Wikipedia:Collagen
cellular_component
GO:0005581
collagen trimer
-
+
-
+
-
+
PMID:12382326
-
+
PMID:12382326
@@ -26314,6 +26415,7 @@ plexiform layer.
PR:000001012
Category=gene. Requested by=CL.
integrin alpha-M
+
@@ -26457,6 +26559,7 @@ plexiform layer.
PR:000001024
Category=gene. Requested by=CL.
neural cell adhesion molecule 1
+
@@ -26541,6 +26644,7 @@ plexiform layer.
PR:000001084
Category=gene. Requested by=CL.
T-cell surface glycoprotein CD8 alpha chain
+
@@ -26669,6 +26773,7 @@ plexiform layer.
PR:000001444
Category=gene. Requested by=CL.
cadherin-5
+
@@ -26701,6 +26806,7 @@ plexiform layer.
PR:000001839
Category=gene. Requested by=CL.
T-cell surface glycoprotein CD5
+
@@ -26742,6 +26848,7 @@ plexiform layer.
PR:000001869
Category=gene. Requested by=CL.
interleukin-7 receptor subunit alpha
+
@@ -26806,6 +26913,7 @@ plexiform layer.
PR:000001945
Category=gene. Requested by=CL.
transferrin receptor protein 1
+
@@ -26875,6 +26983,7 @@ plexiform layer.
PR:000002112
Category=gene. Requested by=CL.
vascular endothelial growth factor receptor 2
+
@@ -26997,6 +27106,7 @@ plexiform layer.
PR:000014841
Category=gene.
sonic hedgehog protein
+
@@ -27038,6 +27148,7 @@ plexiform layer.
PR:000016043
Category=gene. Requested by=CL.
T-cell acute lymphocytic leukemia protein 1
+
@@ -27295,7 +27406,7 @@ plexiform layer.
-
+
@@ -27336,14 +27447,14 @@ plexiform layer.
camera-type eye
-
+
-
+
definitional
@@ -28444,7 +28555,7 @@ plexiform layer.
-
+
The surface (external) layer of ectoderm which begins to proliferate shortly after separation from the neuroectoderm.
merge with non-neural. In vertebrates, the ectoderm has three parts: external ectoderm (also known as surface ectoderm), the neurectoderm (neural crest, and neural tube)
@@ -28469,7 +28580,7 @@ plexiform layer.
external ectoderm
http://upload.wikimedia.org/wikipedia/commons/1/1d/Ectoderm.png
-
+
@@ -28482,7 +28593,7 @@ plexiform layer.
-
+
EHDAA2
@@ -28851,7 +28962,7 @@ plexiform layer.
-
+
@@ -28887,14 +28998,14 @@ plexiform layer.
gastrula stage
-
+
-
+
BILS
@@ -28972,6 +29083,8 @@ plexiform layer.
Staged defined by the formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system.
+
+ In zebrafish, the times of neurulation and segmentation overlap so extensively there is no distinct neurula period of development, such as occurs largely before segmentation in amphibian embryos.
BILS:0000110
BilaDO:0000009
HsapDv:0000012
@@ -28980,6 +29093,7 @@ plexiform layer.
uberon
UBERON:0000110
neurula stage
+ https://github.com/obophenotype/developmental-stage-ontologies/issues/84
https://github.com/obophenotype/uberon/issues/343
@@ -29002,12 +29116,6 @@ plexiform layer.
-
-
-
-
-
-
@@ -29032,6 +29140,7 @@ plexiform layer.
segmentation stage
UBERON:0000111
organogenesis stage
+ https://github.com/obophenotype/developmental-stage-ontologies/issues/84
https://github.com/obophenotype/uberon/issues/533
@@ -29149,7 +29258,6 @@ plexiform layer.
-
@@ -29163,7 +29271,7 @@ plexiform layer.
-
+
@@ -29236,7 +29344,7 @@ plexiform layer.
https://github.com/obophenotype/uberon/issues/661
http://upload.wikimedia.org/wikipedia/commons/0/06/Mouth_illustration-Otis_Archives.jpg
-
+
@@ -29249,7 +29357,7 @@ plexiform layer.
-
+
exceptions in some taxa
@@ -29366,7 +29474,6 @@ plexiform layer.
-
@@ -29375,15 +29482,15 @@ plexiform layer.
-
+
-
-
+
+
A fluid that is composed of blood plasma and erythrocytes.
This class excludes blood analogues, such as the insect analog of blood. See UBERON:0000179 haemolymphatic fluid.
@@ -29425,34 +29532,34 @@ plexiform layer.
blood
-
+
-
+
-
+
-
+
CL:tm
-
+
https://github.com/obophenotype/uberon/issues/1330
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Bgee:AN
@@ -29575,7 +29682,6 @@ plexiform layer.
-
@@ -29641,7 +29747,6 @@ plexiform layer.
-
@@ -29758,7 +29863,7 @@ plexiform layer.
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@@ -29800,14 +29905,14 @@ plexiform layer.
organism substance
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+
this relationship may be too strong and may be weakened in future
@@ -30874,7 +30979,6 @@ plexiform layer.
-
@@ -31141,7 +31245,7 @@ plexiform layer.
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+
Primary germ layer that is the outer of the embryo's three germ layers and gives rise to epidermis and neural tissue.
Primary germ layer that is the outer of the embryonic germ layers and gives rise to epidermis and neural tissue.[AAO]
The Bilateria are triploblastic (with true endoderm, mesoderm, and ectoderm) (...).[well established][VHOG]
@@ -31179,14 +31283,14 @@ plexiform layer.
ectoderm
http://upload.wikimedia.org/wikipedia/commons/1/19/Gray32.png
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+
-
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Bgee:AN
@@ -31239,7 +31343,7 @@ plexiform layer.
-
+
Primary germ layer that lies remote from the surface of the embryo and gives rise to internal tissues such as gut.
The Bilateria are triploblastic (with true endoderm, mesoderm, and ectoderm) (...).[well established][VHOG]
endodermal
@@ -31276,14 +31380,14 @@ plexiform layer.
http://upload.wikimedia.org/wikipedia/commons/c/c0/Endoderm2.png
http://upload.wikimedia.org/wikipedia/commons/d/df/Gray10.png
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+
-
+
Bgee:AN
@@ -31328,7 +31432,7 @@ plexiform layer.
-
+
The middle germ layer of the embryo, between the endoderm and ectoderm.
Primary germ layer that is the middle of the embryonic germ layers.[AAO]
@@ -31373,7 +31477,7 @@ plexiform layer.
mesoderm
http://upload.wikimedia.org/wikipedia/commons/e/e8/Mesoderm.png
-
+
@@ -31386,7 +31490,7 @@ plexiform layer.
-
+
Bgee:AN
@@ -31593,7 +31697,6 @@ plexiform layer.
-
@@ -31609,7 +31712,7 @@ plexiform layer.
-
+
@@ -31675,14 +31778,14 @@ plexiform layer.
cranial nerve II
-
+
-
+
EHDAA2
@@ -31826,7 +31929,7 @@ plexiform layer.
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+
@@ -31900,14 +32003,14 @@ plexiform layer.
Taxon notes:" the ascidian tube-like heart lacks chambers....The ascidian heart is formed after metamorphosis as a simple tube-like structure with a single-layered myoepithelium that is continuous with a single-layered pericar- dial wall. It lacks chambers and endocardium.... The innovation of the chambered heart was a key event in vertebrate evolution, because the chambered heart generates one-way blood flow with high pressure, a critical requirement for the efficient blood supply of large-body vertebrates... all extant vertebrates have hearts with two or more chambers (Moorman and Christoffels 2003)" DOI:10.1101/gad.1485706
heart
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+
-
+
MA
@@ -31985,7 +32088,7 @@ plexiform layer.
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+
@@ -32010,7 +32113,7 @@ plexiform layer.
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+
The brain is the center of the nervous system in all vertebrate, and most invertebrate, animals. Some primitive animals such as jellyfish and starfish have a decentralized nervous system without a brain, while sponges lack any nervous system at all. In vertebrates, the brain is located in the head, protected by the skull and close to the primary sensory apparatus of vision, hearing, balance, taste, and smell[WP].
requires review for applicability to invertebrate structures, e.g. synganglion
@@ -32071,11 +32174,11 @@ plexiform layer.
brain
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+
-
+
@@ -32088,13 +32191,13 @@ plexiform layer.
-
+
FMA
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+
Bgee:AN
@@ -32392,13 +32495,12 @@ plexiform layer.
-
-
-
-
+
+
+
@@ -32423,7 +32525,7 @@ plexiform layer.
-
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@@ -32479,44 +32581,44 @@ plexiform layer.
cornea
http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg
-
+
-
+
-
+
-
+
-
+
MA
-
+
MA
-
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FMA-isa
-
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definitional
@@ -32552,7 +32654,6 @@ plexiform layer.
-
@@ -32706,10 +32807,10 @@ plexiform layer.
-
-
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-
+
+
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+
The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates.
@@ -32760,44 +32861,44 @@ plexiform layer.
retina
http://upload.wikimedia.org/wikipedia/commons/e/ed/Human_eye_cross-sectional_view_grayscale.png
-
+
-
+
-
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-
+
-
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FMA
-
+
FMA
-
+
FMA
-
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EHDAA2
@@ -32871,8 +32972,8 @@ plexiform layer.
-
-
+
+
@@ -32908,24 +33009,24 @@ plexiform layer.
eye
-
+
-
+
-
+
PMID:21062451
-
+
PMID:21062451
@@ -33401,7 +33502,6 @@ plexiform layer.
-
@@ -33495,7 +33595,6 @@ plexiform layer.
-
@@ -33527,7 +33626,7 @@ plexiform layer.
-
+
@@ -33580,14 +33679,14 @@ plexiform layer.
http://upload.wikimedia.org/wikipedia/commons/b/b2/TE-Nervous_system_diagram.svg
http://upload.wikimedia.org/wikipedia/commons/b/ba/Nervous_system_diagram.png
-
+
-
+
Bgee:AN
@@ -33675,7 +33774,7 @@ plexiform layer.
-
+
The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the neural tube derivatives: the brain and spinal cord. In invertebrates it includes central ganglia plus nerve cord.
Part of the nervous system which includes the brain and spinal cord.[AAO]
@@ -33722,7 +33821,7 @@ plexiform layer.
central nervous system
-
+
@@ -33736,7 +33835,7 @@ plexiform layer.
-
+
Bgee:AN
@@ -34483,7 +34582,7 @@ plexiform layer.
-
+
Simple squamous epithelium of mesodermal origin which lines serous membranes. Examples: mesothelium of pleura, mesothelium of peritoneum[FMA]. Wikipedia: The mesothelium is a membrane that forms the lining of several body cavities: the pleura (thoracal cavity), peritoneum (abdominal cavity including the mesentery) and pericardium (heart sac). Mesothelial tissue also surrounds the male internal reproductive organs (the tunica vaginalis testis) and covers the internal reproductive organs of women (the tunica serosa uteri).
AEO:0000111
BTO:0002422
@@ -34508,14 +34607,14 @@ plexiform layer.
mesothelium
http://upload.wikimedia.org/wikipedia/commons/2/25/Mesothelium_peritoneal_wash_high_mag.jpg
-
+
-
+
FMA
@@ -34778,7 +34877,6 @@ plexiform layer.
-
@@ -34870,7 +34968,6 @@ plexiform layer.
-
@@ -34890,7 +34987,7 @@ plexiform layer.
-
+
A tube extending from the mouth to the anus.
@@ -34930,14 +35027,14 @@ plexiform layer.
digestive tract
-
+
-
+
NCBIBook:NBK10107
@@ -35017,7 +35114,7 @@ plexiform layer.
-
+
The ciliary muscle is a ring of smooth muscle in the middle layer of the eye that controls the eye's accommodation for viewing objects at varying distances and regulates the flow of aqueous humour through Schlemm's canal. [WP,unvetted].
BTO:0000654
@@ -35040,7 +35137,7 @@ plexiform layer.
ciliary muscle
http://upload.wikimedia.org/wikipedia/commons/2/28/Gray872.png
-
+
@@ -35059,7 +35156,7 @@ plexiform layer.
-
+
FMA
@@ -35200,7 +35297,7 @@ plexiform layer.
-
+
@@ -35252,14 +35349,14 @@ plexiform layer.
eyelid
https://upload.wikimedia.org/wikipedia/commons/8/84/Eye_makeup.jpg
-
+
-
+
multiple
@@ -35413,7 +35510,6 @@ plexiform layer.
-
@@ -35555,7 +35651,7 @@ plexiform layer.
-
+
@@ -35598,14 +35694,14 @@ plexiform layer.
iris
-
+
-
+
XAO
@@ -35670,7 +35766,6 @@ plexiform layer.
-
@@ -35678,7 +35773,7 @@ plexiform layer.
-
+
@@ -35730,14 +35825,14 @@ plexiform layer.
corneal epithelium
http://upload.wikimedia.org/wikipedia/commons/6/66/Gray871.png
-
+
-
+
ISBN:0781772214
@@ -35832,18 +35927,17 @@ plexiform layer.
-
-
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+
-
-
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+
@@ -35885,44 +35979,44 @@ plexiform layer.
sclera
http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg
-
+
-
+
-
+
-
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-
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FMA
-
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ZFA
-
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ISBN:0781772214
-
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cjm
ISBN:0781772214
Wikipedia
@@ -35962,7 +36056,6 @@ plexiform layer.
-
@@ -35983,7 +36076,7 @@ plexiform layer.
-
+
@@ -36022,14 +36115,14 @@ plexiform layer.
ciliary body
http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg
-
+
-
+
ISBN:0781772214
@@ -36077,14 +36170,14 @@ plexiform layer.
-
+
-
+
@@ -36147,24 +36240,24 @@ plexiform layer.
optic choroid
http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg
-
+
-
+
-
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MA
-
+
Wikipedia
@@ -36257,7 +36350,6 @@ plexiform layer.
-
@@ -36265,7 +36357,7 @@ plexiform layer.
-
+
@@ -36314,14 +36406,14 @@ plexiform layer.
substantia propria of cornea
http://upload.wikimedia.org/wikipedia/commons/6/66/Gray871.png
-
+
-
+
cjm
ISBN:0781772214
Wikipedia
@@ -36398,9 +36490,9 @@ plexiform layer.
-
-
-
+
+
+
A double layer covering the ciliary body that produces aqueous humor.
BTO:0001770
@@ -36420,15 +36512,15 @@ plexiform layer.
ciliary epithelium
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-
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@@ -36441,19 +36533,19 @@ plexiform layer.
-
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MA
-
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MP
-
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Wikipedia
@@ -36576,7 +36668,7 @@ plexiform layer.
-
+
@@ -36637,14 +36729,14 @@ plexiform layer.
pigmented layer of retina
http://upload.wikimedia.org/wikipedia/commons/5/55/Gray881.png
-
+
-
+
Wikipedia
@@ -36748,7 +36840,7 @@ plexiform layer.
-
+
@@ -36782,14 +36874,14 @@ plexiform layer.
photoreceptor layer of retina
http://upload.wikimedia.org/wikipedia/commons/5/55/Gray881.png
-
+
-
+
ZFA
@@ -36962,7 +37054,7 @@ plexiform layer.
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+
@@ -37009,14 +37101,14 @@ plexiform layer.
outer nuclear layer of retina
-
+
-
+
soma
ZFA
@@ -37213,7 +37305,6 @@ plexiform layer.
-
@@ -37354,9 +37445,8 @@ plexiform layer.
-
-
+
@@ -37415,7 +37505,7 @@ plexiform layer.
ganglionic layer of retina
http://upload.wikimedia.org/wikipedia/commons/5/55/Gray881.png
-
+
@@ -37428,7 +37518,7 @@ plexiform layer.
-
+
FMA
@@ -37504,7 +37594,7 @@ plexiform layer.
-
+
@@ -37560,14 +37650,14 @@ plexiform layer.
nerve fiber layer of retina
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FMA
@@ -37639,7 +37729,6 @@ plexiform layer.
-
@@ -37946,7 +38035,7 @@ plexiform layer.
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@@ -37982,14 +38071,14 @@ plexiform layer.
aqueous humor of eyeball
http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg
-
+
-
+
FMA def states A and P
located_in in EHDAA2
VHOG
@@ -38171,7 +38260,7 @@ plexiform layer.
-
+
@@ -38195,7 +38284,7 @@ plexiform layer.
vitreous body
http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg
-
+
@@ -38208,7 +38297,7 @@ plexiform layer.
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+
neural ectoderm of optic cup
ISBN:0781772214
@@ -38343,8 +38432,8 @@ plexiform layer.
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-
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+
@@ -38377,24 +38466,24 @@ plexiform layer.
anterior segment of eyeball
http://upload.wikimedia.org/wikipedia/commons/b/ba/Cataract_in_human_eye.png
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-
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FMA
-
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cjm
@@ -38445,8 +38534,8 @@ plexiform layer.
-
-
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+
@@ -38476,24 +38565,24 @@ plexiform layer.
posterior segment of eyeball
http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg
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-
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FMA
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cjm
@@ -38528,11 +38617,10 @@ plexiform layer.
-
-
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@@ -38582,15 +38670,15 @@ plexiform layer.
conjunctiva
http://upload.wikimedia.org/wikipedia/commons/5/55/Gray883.png
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-
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@@ -38603,19 +38691,19 @@ plexiform layer.
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cjm
-
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MA
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ISBN:0781772214
@@ -38679,7 +38767,7 @@ plexiform layer.
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+
The most anterior region of the brain including both the telencephalon and diencephalon.
@@ -38726,14 +38814,14 @@ plexiform layer.
forebrain
http://upload.wikimedia.org/wikipedia/commons/5/54/EmbryonicBrain.svg
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definitional
@@ -38809,14 +38897,14 @@ plexiform layer.
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The midbrain is the middle division of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes a ventral part containing the cerebral peduncles and a dorsal tectum containing the corpora quadrigemina and that surrounds the aqueduct of Sylvius connecting the third and fourth ventricles)[GO].
developmental relationships need revised
@@ -38869,24 +38957,24 @@ plexiform layer.
midbrain
http://upload.wikimedia.org/wikipedia/commons/f/f9/Human_brain_inferior_view_description.JPG
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definitional
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Bgee:AN
@@ -38989,14 +39077,14 @@ plexiform layer.
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The division of the forebrain that develops from the foremost primary cerebral vesicle.
@@ -39059,24 +39147,24 @@ plexiform layer.
diencephalon
http://upload.wikimedia.org/wikipedia/commons/5/54/EmbryonicBrain.svg
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-
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definitional
-
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definitional
@@ -39369,7 +39457,6 @@ plexiform layer.
-
@@ -39513,7 +39600,7 @@ plexiform layer.
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Ventral part of the midbrain, separated from the hindbrain by the isthmus[ISBN:0471888893]. Subdivision of the midbrain lying anterior to the tectum and posterior to the substantia nigra and cerebral peduncle[FMA] The part of the midbrain extending from the substantia nigra to the cerebral aqueduct in a horizontal section of the midbrain. It forms the floor of the midbrain that surrounds the cerebral aqueduct[WP].
Together, our results reveal a shared basic organization in the tegmental domains of the diencephalon and midbrain of developing lamprey, indicating early appearance of the domain in vertebrate phylogeny.[well established][VHOG]
@@ -39553,14 +39640,14 @@ plexiform layer.
midbrain tegmentum
http://upload.wikimedia.org/wikipedia/commons/b/b6/Gray712.png
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ZFA
@@ -39731,7 +39818,6 @@ plexiform layer.
-
@@ -39740,8 +39826,8 @@ plexiform layer.
-
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+
@@ -39754,7 +39840,7 @@ plexiform layer.
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@@ -39813,34 +39899,34 @@ plexiform layer.
blood vessel
http://upload.wikimedia.org/wikipedia/commons/2/29/Circulatory_System_en.svg
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-
+
-
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AEO
-
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EHDAA2
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GO:0072360
@@ -40199,7 +40285,7 @@ plexiform layer.
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@@ -40212,7 +40298,7 @@ plexiform layer.
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The most posterior of the three principal regions of the brain. In mammals and birds the hindbrain is divided into a rostral metencephalon and a caudal myelencephalon. In zebrafish, with the exception of the cerebellum, the ventral remainder of the metencephalon can be separated only arbitrarily from the more caudal myelencephalic portion of the medulla oblongata (From: Neuroanatomy of the Zebrafish Brain)[ZFA]. Organ component of neuraxis that has as its parts the pons, cerebellum and medulla oblongata[FMA].
@@ -40263,25 +40349,25 @@ plexiform layer.
hindbrain
http://upload.wikimedia.org/wikipedia/commons/5/54/EmbryonicBrain.svg
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-
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modified-source-relation
ABA
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Bgee:AN
@@ -40676,7 +40762,6 @@ plexiform layer.
-
@@ -41093,7 +41178,6 @@ plexiform layer.
-
@@ -41102,7 +41186,7 @@ plexiform layer.
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Vasculature that is part of the eye region.
not part of the eye in ZFA. Note this changed to a blood vessel in ZFA
@@ -41123,14 +41207,14 @@ plexiform layer.
vasculature of eye
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ISBN:0781772214
@@ -41170,7 +41254,6 @@ plexiform layer.
-
@@ -41190,7 +41273,7 @@ plexiform layer.
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@@ -41224,14 +41307,14 @@ plexiform layer.
musculoskeletal system
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check ctenophore
@@ -41369,15 +41452,15 @@ plexiform layer.
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-
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Part of the central nervous system located in the vertebral canal continuous with and caudal to the brain; demarcated from brain by plane of foramen magnum. It is composed of an inner core of gray matter in which nerve cells predominate, and an outer layer of white matter in which myelinated nerve fibers predominate, and surrounds the central canal. (CUMBO).
TODO - add superclass to unify with VNC?
@@ -41434,34 +41517,34 @@ plexiform layer.
spinal cord
http://upload.wikimedia.org/wikipedia/commons/5/58/Spinal_cord_direv.svg
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-
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-
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ZFA
-
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definitional
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definitional
@@ -41902,9 +41985,8 @@ plexiform layer.
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-
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@@ -41945,14 +42027,14 @@ plexiform layer.
coelemic cavity lumen
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definitional
@@ -42060,9 +42142,9 @@ plexiform layer.
-
-
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+
+
@@ -42117,15 +42199,15 @@ plexiform layer.
notochord
http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png
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-
+
-
+
@@ -42144,19 +42226,19 @@ plexiform layer.
-
+
http://tolweb.org/Chordata/2499
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ZFA
-
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EHDAA2
@@ -42239,11 +42321,10 @@ plexiform layer.
-
-
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+
Somites are spheres of epithelial cells that form sequentially along the anterior-posterior axis of the embryo through mesenchymal to epithelial transition of the presomitic mesoderm.
currently classified as an epithelial vesicle, consistent with EHDAA2 and https://github.com/obophenotype/uberon/wiki/The-neural-crest. Consider making 'somitic mesoderm' a separate term and correlate with regionalization processes. Consider moving ZFA term to 'trunk somite' as it is part of the trunk
@@ -42289,11 +42370,11 @@ plexiform layer.
somite
http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png
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+
-
+
@@ -42306,13 +42387,13 @@ plexiform layer.
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GOTAX:0000352
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ZFA
@@ -42425,12 +42506,12 @@ plexiform layer.
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A specialized region of ectoderm found between the neural ectoderm (neural plate) and non-neural ectoderm and composed of highly migratory pluripotent cells that delaminate in early embryonic development from the dorsal neural tube and give rise to an astounding variety of differentiated cell types[MP].
consider including subclasses for pre- and post- migratory (e.g. sheets/paths/streams).
@@ -42470,66 +42551,66 @@ plexiform layer.
http://upload.wikimedia.org/wikipedia/commons/5/5f/Gray644.png
https://upload.wikimedia.org/wikipedia/commons/8/8f/Neural_Crest.png
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XAO
https://github.com/obophenotype/uberon/wiki/The-neural-crest
-
+
Hall and others restrict NC to vertebrates but we opt for a less restrictive constraint to avoid inconsistencies when areas such as P1 area of pallium in hagfishes inherit cell lineage from telecephalon-contributing NC cells
ISBN:0073040584
-
+
BTO
-
+
PMID:11523831
-
+
pre migratory https://github.com/obophenotype/uberon/wiki/The-neural-crest
-
+
PMID:11523831
@@ -42910,17 +42991,16 @@ plexiform layer.
-
-
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-
+
Anatomical system that is involved in the production of hematopoietic cells.
Anatomical system that consists of the blood and blood forming tissues.[AAO]
@@ -42963,24 +43043,24 @@ plexiform layer.
hematopoietic system
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-
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FMA
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definitional
@@ -43045,8 +43125,8 @@ plexiform layer.
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+
@@ -43072,11 +43152,11 @@ plexiform layer.
iris epithelium
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@@ -43089,13 +43169,13 @@ plexiform layer.
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MA
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MP
@@ -43245,7 +43325,7 @@ plexiform layer.
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Ectodermal placode that develops in the head into a part of the sensory nervous system. With a few exceptions (lens, adenohypophyseal), cranial placodes are neurogenic.
Do not merge with neurogenic placode
Comparisons of developmental gene expression suggest that the anterior ectoderm in amphioxus may be homologous to the vertebrate olfactory placode, the only vertebrate placode with primary, not secondary, neurons
@@ -43265,7 +43345,7 @@ plexiform layer.
cranial placode
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+
@@ -43278,7 +43358,7 @@ plexiform layer.
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+
PMID:11523831
PMID:22512454
@@ -43380,7 +43460,6 @@ plexiform layer.
-
@@ -43484,7 +43563,7 @@ plexiform layer.
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+
@@ -43497,7 +43576,7 @@ plexiform layer.
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The part of the brain that is the morphological boundary between the midbrain and hindbrain and that is the location of an organizing center which patterns the midbrain and hindbrain primordia of the neural plate.
consider adding class for organizer. Consider adding separate class for isthmus as a structure
Lampreys also have an MHB [midbrain hindbrain boundary], expressing a similar repertoire of regulatory gene cognates as in gnathostomes.[well established][VHOG]
@@ -43527,11 +43606,11 @@ plexiform layer.
midbrain-hindbrain boundary
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+
@@ -43545,13 +43624,13 @@ plexiform layer.
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ZFA
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ZFA
@@ -43716,7 +43795,7 @@ plexiform layer.
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Unsegmented field of paraxial mesoderm present posterior to the most recently formed somite pair, from which somites will form.
Unsegmented field of paraxial mesoderm present posterior to the most recently formed somite pair, from which somites will form. Kimmel et al, 1995.[TAO]
It is reasonable to assume that the proximate invertebrate ancestor of the vertebrates had an amphioxus-like tail bud in its larval stage. This archetypal tail bud would have (...) (3) lacked any component of mesenchyme cells, (4) budded off new mesodermal segments directly, without any intervening zone of presomitic mesoderm (...). Then, early in vertebrate evolution, epithelium-to-mesenchyme interconversions (and the gene networks for effecting them) became prominent features of development. (...) In any case, conspicuous mesenchymal components tended to be added to the vertebrate tail bud itself. In addition, a mesenchymatous presomitic mesoderm (not a part of the tail bud proper) came to intervene between the tail bud and the forming somites.[well established][VHOG]
@@ -43741,14 +43820,14 @@ plexiform layer.
presomitic mesoderm
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Bgee:AN
@@ -43911,7 +43990,6 @@ plexiform layer.
-
@@ -43991,7 +44069,7 @@ plexiform layer.
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@@ -44029,7 +44107,7 @@ plexiform layer.
eye primordium
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@@ -44042,7 +44120,7 @@ plexiform layer.
-
+
PMID:16496288
XAO
@@ -44096,11 +44174,10 @@ plexiform layer.
-
-
-
+
+
@@ -44129,24 +44206,24 @@ plexiform layer.
optic cup
-
+
-
+
-
+
ZFA
-
+
ZFA
@@ -44208,11 +44285,10 @@ plexiform layer.
-
-
+
@@ -44253,7 +44329,7 @@ plexiform layer.
lens placode
http://upload.wikimedia.org/wikipedia/commons/2/2f/Gray864.png
-
+
@@ -44266,7 +44342,7 @@ plexiform layer.
-
+
ZFA
@@ -44327,13 +44403,12 @@ plexiform layer.
-
-
-
-
+
+
+
A region of embryonic ectodermal cells that lie directly above the notochord. During neurulation, they change shape and produce an infolding of the neural plate (the neural fold) that then seals to form the neural tube[XAO]. The earliest recognizable dorsal ectodermal primordium of the central nervous system present near the end of gastrulation before infolding to form the neural keel; consists of a thickened pseudostratified epithelium[ZFA].
The earliest recognizable dorsal ectodermal primordium of the central nervous system present near the end of gastrulation before infolding to form the neural keel; consists of a thickened pseudostratified epithelium. Kimmel et al, 1995.[TAO]
(...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...).[well established][VHOG]
@@ -44365,34 +44440,34 @@ plexiform layer.
neural plate
https://upload.wikimedia.org/wikipedia/commons/8/8f/Neural_Crest.png
-
+
-
+
-
+
-
+
GOTAX:0000352
-
+
Wikipedia
-
+
Bgee:AN
@@ -44442,7 +44517,6 @@ plexiform layer.
-
@@ -44504,7 +44578,7 @@ plexiform layer.
-
+
The paraxial mesoderm is the mesoderm located bilaterally adjacent to the notochord and neural tube[GO].
Mesoderm lateral to the neural tube and notochord that is divided into cranial and post-cranial portions. The trunk portions further segment into somites.[AAO]
Presently, Cephalochordata, Urochordata, and Vertebrata are placed as subphyla of the phylum Chordata, in which the overall organization of embryonic tissues (dorsal hollow nerve cord, ventral digestive tract, axial notochord, and bilateral paraxial mesoderm) is largely conserved. In contrast, the echinoderms and hemichordates are sister groups of the chordates and they lack the notochord and paraxial mesoderm. Thus, the basic mesodermal organization of vertebrates must have appeared first in the common ancestor of the chordates.[well established][VHOG]
@@ -44533,7 +44607,7 @@ plexiform layer.
paraxial mesoderm
http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png
-
+
@@ -44546,7 +44620,7 @@ plexiform layer.
-
+
Bgee:AN
@@ -44614,7 +44688,6 @@ plexiform layer.
-
@@ -44659,7 +44732,7 @@ plexiform layer.
-
+
@@ -44703,7 +44776,7 @@ plexiform layer.
lateral plate mesoderm
http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png
-
+
@@ -44716,7 +44789,7 @@ plexiform layer.
-
+
EHDAA2
VHOG
@@ -44799,17 +44872,16 @@ plexiform layer.
-
-
-
+
+
-
+
Bilateral groups of cells consisting of three rows: one row of endocardial precursors medially and two rows of myocardical precursors laterally. The two populations fuse at the midline to form the heart rudiment or cone.
should probably be merged with heart rudiment.
Bilateral groups of cells consisting of three rows: one row of endocardial precursors medially and two rows of myocardical precursors laterally. The two populations fuse at the midline between 21 and 26 somites to form the heart rudiment or cone. Stainier 2001.[TAO]
@@ -44829,15 +44901,15 @@ plexiform layer.
heart primordium
-
+
-
+
-
+
@@ -44850,19 +44922,19 @@ plexiform layer.
-
+
ZFA
-
+
ZFA
-
+
XAO
@@ -44917,8 +44989,8 @@ plexiform layer.
-
-
+
+
Ventral somitic compartment that is a precursor of the axial skeleton[XAO]. Sclerotomes eventually differentiate into the vertebrae and most of the skull. The caudal (posterior) half of one sclerotome fuses with the rostral (anterior) half of the adjacent one to form each vertebra. From their initial location within the somite, the sclerotome cells migrate medially towards the notochord. These cells meet the sclerotome cells from the other side to form the vertebral body. From this vertebral body, sclerotome cells move dorsally and surround the developing spinal cord, forming the vertebral arch[WP].
Skeletogenic portion of somites.[AAO]
The vertebrate sclerotome has no equivalent in amphioxus and is a novelty linked with the evolution of the axial skeleton.[well established][VHOG]
@@ -44945,11 +45017,11 @@ plexiform layer.
sclerotome
http://upload.wikimedia.org/wikipedia/commons/9/96/Gray65.png
-
+
-
+
@@ -44968,13 +45040,13 @@ plexiform layer.
-
+
VHOG:0000680
-
+
ZFA
@@ -45134,7 +45206,6 @@ plexiform layer.
-
@@ -45386,7 +45457,6 @@ plexiform layer.
-
@@ -45394,7 +45464,7 @@ plexiform layer.
-
+
Mesenchyme that is part of a developing camera-type eye.
TODO - change mesenchyme relationships to precursor_of
EHDAA2:0000485
@@ -45406,14 +45476,14 @@ plexiform layer.
UBERON:0003314
eye mesenchyme
-
+
-
+
EHDAA2
@@ -45586,7 +45656,6 @@ plexiform layer.
-
@@ -45711,7 +45780,6 @@ plexiform layer.
-
@@ -46220,7 +46288,6 @@ plexiform layer.
-
@@ -46267,7 +46334,6 @@ plexiform layer.
-
@@ -46275,7 +46341,7 @@ plexiform layer.
-
+
The part of the coelom in the embryo between the somatopleuric and splanchnopleuric mesoderm; the principal body cavities of the trunk (thoracic, abdominal, and pelvic) arise from this embryonic part of the coelom.
consider merging with coelom. TODO - add spatial relationships to halves of LPM. Note the OG places XAO and ZFA coelem terms here. editor note: TODO check ZFA, which appears to be a structure present in adults
(...) I regard it unlikely that coeloms of all bilaterian animals are comparable and evolved very early. Considering all these questions, few convincing characters concerning the evolution of body cavities remain to be named. (...) A segmental coelom appears to have evolved at least two times, in Annelida and in Myomerata (Acrania and Craniota).[well established][VHOG]
@@ -46291,14 +46357,14 @@ plexiform layer.
intraembryonic coelom
-
+
-
+
Wikipedia
@@ -46389,7 +46455,6 @@ plexiform layer.
-
@@ -46404,7 +46469,7 @@ plexiform layer.
-
+
The part of the retina that contains neurons and photoreceptor cells[GO].
(...) an essentially similar sequence of events occurs during the embryonic development of the vertebrate eye. The eye initially develops as a single median evagination of the diencephalon that soon bifurcates to form the paired optic vesicles. As each optic vesicle grows towards the body surface, its proximal part narrows as the optic stalk, and its distal part invaginates to form a two-layered optic cup. (...) The outer layer of the optic cup becomes the pigment layer of the retina, whereas the inner layer differentiates into the photoreceptive cells and neuronal layers of the retina.[well established][VHOG]
@@ -46436,14 +46501,14 @@ plexiform layer.
retinal neural layer
-
+
-
+
Bgee:AN
@@ -46701,7 +46766,7 @@ plexiform layer.
-
+
The layer of undifferentiated, proliferating cells that line the neural tube lumen that is the immediate transformation of the germinal neuroepithelium.
consider merging with 'ventricular zone'; note that the MA class probably does not belong here, as this is an embryonic structure
The layer of undifferentiated, proliferating cells that line the neural tube lumen
@@ -46719,7 +46784,7 @@ plexiform layer.
neural tube ventricular layer
-
+
@@ -46732,7 +46797,7 @@ plexiform layer.
-
+
NCBIBook:NBK10047
@@ -46784,7 +46849,6 @@ plexiform layer.
-
@@ -46793,7 +46857,7 @@ plexiform layer.
-
+
@@ -46817,7 +46881,7 @@ plexiform layer.
neural tube mantle layer
-
+
@@ -46830,7 +46894,7 @@ plexiform layer.
-
+
by division
NCBIBook:NBK10047
@@ -46860,7 +46924,6 @@ plexiform layer.
-
@@ -46868,7 +46931,7 @@ plexiform layer.
-
+
@@ -46885,14 +46948,14 @@ plexiform layer.
neural tube marginal layer
-
+
-
+
forms from axons
@@ -47088,7 +47151,6 @@ plexiform layer.
-
@@ -47133,7 +47195,6 @@ plexiform layer.
-
@@ -47167,12 +47228,11 @@ plexiform layer.
-
-
-
-
+
+
+
@@ -47205,34 +47265,34 @@ plexiform layer.
optic vesicle
http://upload.wikimedia.org/wikipedia/commons/e/e0/Gray863.png
-
+
-
+
-
+
-
+
ZFA
-
+
GO-def
-
+
ZFA
@@ -47283,7 +47343,6 @@ plexiform layer.
-
@@ -47349,8 +47408,8 @@ plexiform layer.
-
-
+
+
A specific region of the lateral mesoderm that will form the primary beating heart tube. In mammals the primary heart field gives rise to the left ventricle.
this term denotes the primary heart field; GO:0003128 denotes the superclass of primary and secondary: specific region of the lateral mesoderm into the area which will form the primary beating heart tube[GO:0003138]
XAO:0004185
@@ -47363,24 +47422,24 @@ plexiform layer.
UBERON:0004140
primary heart field
-
+
-
+
-
+
GO:0003128
-
+
https://orcid.org/0000-0003-3308-6245
@@ -47439,7 +47498,7 @@ plexiform layer.
-
+
An epithelial tube that will give rise to the mature heart.
the paired, longitudinal, endothelial-lined channels formed from the cardiogenic mesoderm in embryonic development; angiogenic cell clusters (aka angioblastic cords) located in a horse-shoe shape configuration in the cardiogenic plate coalesce to form the right and left endocardial heart tubes which then fuse in cephalo-caudal direction to form a single primitive heart tube.
AAO:0010411
@@ -47459,14 +47518,14 @@ plexiform layer.
heart tube
-
+
-
+
ZFA-modified
@@ -47547,7 +47606,7 @@ plexiform layer.
-
+
@@ -47563,14 +47622,14 @@ plexiform layer.
eye muscle
-
+
-
+
MA
@@ -47774,7 +47833,7 @@ plexiform layer.
-
+
A transparent homogeneous acellular layer found between the substantia propria and the endothelial layer of the cornea[MP].
Acellular anatomical structure composed of collagen, Descemet's membrane is secreted as a basement membrane of the corneal endothelium. Located between the stroma and the corneal endothelium, it is approximately 0.15 micrometer thick at 6 months post-fertilization.[ZFIN]
@@ -47804,14 +47863,14 @@ plexiform layer.
Descemet's membrane
https://github.com/obophenotype/uberon/issues/15
-
+
-
+
Cline et al
@@ -47902,7 +47961,6 @@ plexiform layer.
-
@@ -48092,7 +48150,6 @@ plexiform layer.
-
@@ -48202,7 +48259,6 @@ plexiform layer.
-
@@ -48294,7 +48350,6 @@ plexiform layer.
-
@@ -48467,7 +48522,6 @@ plexiform layer.
-
@@ -48597,7 +48651,7 @@ plexiform layer.
-
+
Organ consisting of skeletal tissue. Encompasses whole bones, fused bones, cartilaginious elements, teeth, dermal denticles.
Organ entity that is typically involved in mechanical support and may have different skeletal tissue compositions at different stages.[VSAO]
Organ entity that may have different tissue compositions at different stages and is typically involved in mechanical support.[TAO]
@@ -48613,14 +48667,14 @@ plexiform layer.
skeletal element
-
+
-
+
VSAO
@@ -48665,7 +48719,7 @@ plexiform layer.
-
+
@@ -48704,14 +48758,14 @@ plexiform layer.
UBERON:0004770
articular system
-
+
-
+
FMA
@@ -49273,7 +49327,6 @@ plexiform layer.
-
@@ -49619,7 +49672,7 @@ plexiform layer.
-
+
Portion of primordial embryonic connective tissue of the developing head, consisting of mesenchymal cells supported in interlaminar jelly, that derive mostly from the mesoderm and contribute to head connective tissue, bone and musculature in conjunction with cranial neural crest cells.
Mesoderm that will give rise, along with cranial neural crest cells, to connective tissue, bone and musculature in the head. (Source: BioGlossary, www.Biology-Text.com)[TAO]
EFO:0003492
@@ -49641,14 +49694,14 @@ plexiform layer.
head mesenchyme
-
+
-
+
EHDAA2
@@ -49715,7 +49768,7 @@ plexiform layer.
-
+
Mesenchyme that is part of a developing trunk.
EFO:0003485
EHDAA2:0002092
@@ -49731,14 +49784,14 @@ plexiform layer.
trunk mesenchyme
-
+
-
+
EHDAA2
@@ -49761,7 +49814,7 @@ plexiform layer.
-
+
The posterior part of the developing vertebrate hindbrain or the corresponding part of the adult brain composed of the medulla oblongata and a portion of the fourth ventricle; as well as the glossopharyngeal nerve (CN IX), vagus nerve (CN X), accessory nerve (CN XI), hypoglossal nerve (CN XII), and a portion of the vestibulocochlear nerve (CN VIII).[BTO,WP].
The posterior of the two brain vesicles formed by specialization of the rhombencephalon in the developing embryo, it comprises the medulla oblongata. [TFD][VHOG]
@@ -49786,14 +49839,14 @@ plexiform layer.
myelencephalon
http://upload.wikimedia.org/wikipedia/commons/5/54/EmbryonicBrain.svg
-
+
-
+
definitional
@@ -50217,7 +50270,6 @@ plexiform layer.
-
@@ -50321,7 +50373,7 @@ plexiform layer.
-
+
Portion of tissue that is part of the eye and gives rise to the mature, fully layered cornea.
TAO:0002188
ZFA:0001688
@@ -50329,7 +50381,7 @@ plexiform layer.
UBERON:0005427
corneal primordium
-
+
@@ -50348,7 +50400,7 @@ plexiform layer.
-
+
ZFA
@@ -50371,7 +50423,7 @@ plexiform layer.
-
+
Multi-tissue structure that arises from the heart rudiment and will become the heart tube.
EHDAA2:0001512
EHDAA:424
@@ -50389,14 +50441,14 @@ plexiform layer.
primitive heart tube
-
+
-
+
ZFA
@@ -50599,7 +50651,7 @@ plexiform layer.
-
+
A delimited region of dense mesenchyme within looser mesenchyme.
AEO:0000148
EHDAA2_RETIRED:0003148
@@ -50609,7 +50661,7 @@ plexiform layer.
UBERON:0005856
developing mesenchymal condensation
-
+
@@ -50628,7 +50680,7 @@ plexiform layer.
-
+
AEO-modified-relation
@@ -50687,9 +50739,9 @@ plexiform layer.
-
-
-
+
+
+
A serous sac which is the aggregate of the conjunctiva plus the conjunctival space.
EMAPA:18233
FMA:20291
@@ -50700,15 +50752,15 @@ plexiform layer.
UBERON:0005908
conjunctival sac
-
+
-
+
-
+
@@ -50721,19 +50773,19 @@ plexiform layer.
-
+
FMA
-
+
HPO:pr
-
+
MA
@@ -50754,7 +50806,6 @@ plexiform layer.
-
@@ -50989,7 +51040,7 @@ plexiform layer.
-
+
@@ -51012,14 +51063,14 @@ plexiform layer.
future diencephalon
-
+
-
+
EHDAA2
@@ -51202,7 +51253,7 @@ plexiform layer.
-
+
@@ -51226,14 +51277,14 @@ plexiform layer.
future spinal cord
-
+
-
+
EHDAA2
@@ -51270,7 +51321,7 @@ plexiform layer.
-
+
The notochordal plate is the dorsal part of the notochordal process when the ventral portion breaks down. It is continuous laterally with the endoderm that composes the roof of the primitive foregut and is in contact dorsally with the neural tube. The folding off of the notochordal plate gives rise to the notochord.
TODO - check ordering; awaiting confirmation from JB
The notochordal plate is the dorsal part of the notochordal process when the ventral portion breaks down. It is continuous laterally with the endoderm that composes the roof of the primitive foregut and is in contact dorsally with the neural tube. The folding off of the notochordal plate gives rise to the notochord. [Carson_JL, Dehart_DB, Developmental_Dynamics_(1994)_201:_260-278, Gesteland_K_and_Schoenwolf_GC, Inagaki_T, Morphogenesis_of_the_murine_node_and_notochordal_plate, The_prechordal_plate, Vrablic_T, see_Mueller_F_and_O'Rahilly_R, the_rostral_end_of_the_notochord_and_nearby_median_features_in_staged_human_embryos._Cells_Tissues_Organs_(2003)_173:_1-20_and_Sulik_K][VHOG]
@@ -51285,7 +51336,7 @@ plexiform layer.
notochordal plate
-
+
@@ -51298,7 +51349,7 @@ plexiform layer.
-
+
EHDAA2
@@ -51328,7 +51379,6 @@ plexiform layer.
-
@@ -51336,7 +51386,7 @@ plexiform layer.
-
+
A midline cellular cord formed from the migration of mesenchymal cells from the primitive knot.
EHDAA2:0001279
EHDAA:224
@@ -51353,14 +51403,14 @@ plexiform layer.
The notochordal process grows cranially until it reaches the prechordal plate, the future site of the mouth. In this area the ectoderm is attached directly to the endoderm without intervening mesoderm. This area is known as the oropharyngeal membrane, and it will break down to become the mouth. At the other end of the primitive streak the ectoderm is also fused directly to the endoderm; this is known as the cloacal membrane (proctodeum), or primordial anus.
notochordal process
-
+
-
+
EHDAA2
@@ -51691,7 +51741,6 @@ plexiform layer.
-
@@ -51954,7 +52003,6 @@ plexiform layer.
-
@@ -52041,7 +52089,6 @@ plexiform layer.
-
@@ -52268,7 +52315,7 @@ plexiform layer.
-
+
A hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood or analogs[GO,modified].
note we reserve the subclass 'heart' from the vertebrate multi-chambered heart. 'The first heart-like organ is believed to have appeared 500my ago in an ancestral bilaterian'. Amniotes: four-chambered heart. Amphibians: two atria, one ventricle, pulmonary; fish: single atrium and ventricle; amphioxus: tubular, non-striated, closed, unidirectional; ascidians: tubular, striated, open, bidirectional; arthropods: tubular, open; C elegans: contractile pharynx; Cnideria: striated muscle cells associated with gastrodermis
SPD:0000130
@@ -52283,14 +52330,14 @@ plexiform layer.
Gene notes: Bmp, Nkx, Gata
primary circulatory organ
-
+
-
+
GO uses blood circulation generically to include the haemolymphatic fluid of arthropods
@@ -52379,7 +52426,6 @@ plexiform layer.
-
@@ -52446,8 +52492,8 @@ plexiform layer.
-
-
+
+
@@ -52474,24 +52520,24 @@ plexiform layer.
presumptive hindbrain
-
+
-
+
-
+
XAO-abduced
-
+
cjm
@@ -52548,7 +52594,7 @@ plexiform layer.
-
+
@@ -52567,14 +52613,14 @@ plexiform layer.
presumptive midbrain hindbrain boundary
-
+
-
+
ZFA
@@ -52613,7 +52659,7 @@ plexiform layer.
-
+
@@ -52630,14 +52676,14 @@ plexiform layer.
presumptive segmental plate
-
+
-
+
https://github.com/obophenotype/uberon/wiki/The-neural-crest
EDHAA2
@@ -52736,7 +52782,7 @@ plexiform layer.
-
+
@@ -52762,7 +52808,7 @@ plexiform layer.
presumptive paraxial mesoderm
-
+
@@ -52778,7 +52824,7 @@ plexiform layer.
-
+
https://github.com/obophenotype/uberon/issues/1277
@@ -52860,7 +52906,7 @@ plexiform layer.
-
+
A neural decussation that is part of a diencephalon.
FMA:62446
diencephalon decussation
@@ -52868,7 +52914,7 @@ plexiform layer.
UBERON:0007425
decussation of diencephalon
-
+
@@ -52881,7 +52927,7 @@ plexiform layer.
-
+
Obol
@@ -52955,9 +53001,8 @@ plexiform layer.
-
-
+
Mesenchyme with little extracellular matrix.
AEO:0000146
EHDAA2:0003146
@@ -52965,7 +53010,7 @@ plexiform layer.
UBERON:0007524
dense mesenchyme tissue
-
+
@@ -52978,7 +53023,7 @@ plexiform layer.
-
+
AEO
@@ -53218,7 +53263,7 @@ plexiform layer.
-
+
An axon tract that is part of a brain.
the NIFSTD class 'nerve tract' is classified under 'regional part of brain', so it may seem like it belongs here, but actually includes spinal cord tracts
FMA:83848
@@ -53228,14 +53273,14 @@ plexiform layer.
UBERON:0007702
tract of brain
-
+
-
+
cjm
@@ -53263,7 +53308,7 @@ plexiform layer.
-
+
Anatomical system that consists of all blood and lymph vessels.
consider merging with vasculature
The cardiovascular and lymphatic systems, collectively[ncithesaurus:Vascular_System].
@@ -53280,14 +53325,14 @@ plexiform layer.
vascular system
-
+
-
+
MA
@@ -53413,7 +53458,6 @@ plexiform layer.
-
@@ -53421,7 +53465,7 @@ plexiform layer.
-
+
@@ -53438,14 +53482,14 @@ plexiform layer.
UBERON:0009142
entire embryonic mesenchyme
-
+
-
+
EHDAA2
@@ -53541,8 +53585,8 @@ plexiform layer.
-
-
+
+
TODO - developmental relationships for lines
TAO:0007044
ZFA:0007044
@@ -53552,24 +53596,24 @@ plexiform layer.
UBERON:0009615
midbrain hindbrain boundary neural plate
-
+
-
+
-
+
ZFA
-
+
https://github.com/obophenotype/uberon/issues/438
Bgee:AN
@@ -53603,14 +53647,14 @@ plexiform layer.
-
+
-
+
@@ -53635,24 +53679,24 @@ plexiform layer.
presumptive midbrain
-
+
-
+
-
+
ZFA
-
+
ZFA
@@ -53698,7 +53742,7 @@ plexiform layer.
-
+
EHDAA2:0002094
trunk and cervical paraxial mesenchyme
uberon
@@ -53706,14 +53750,14 @@ plexiform layer.
UBERON:0009618
trunk paraxial mesoderm
-
+
-
+
EHDAA2
@@ -53735,7 +53779,7 @@ plexiform layer.
-
+
EFO:0003704
TAO:0005041
ZFA:0005041
@@ -53745,14 +53789,14 @@ plexiform layer.
anterior lateral plate mesoderm
-
+
-
+
ZFA
@@ -53808,14 +53852,14 @@ plexiform layer.
-
+
EHDAA2:0001315
EHDAA:1122
uberon
UBERON:0009920
optic neural crest
-
+
@@ -53828,7 +53872,7 @@ plexiform layer.
-
+
EHDAA2
@@ -53962,7 +54006,7 @@ plexiform layer.
-
+
@@ -53987,14 +54031,14 @@ plexiform layer.
eyeball of camera-type eye
-
+
-
+
FMA
@@ -54035,8 +54079,8 @@ plexiform layer.
-
-
+
+
Portion of tissue that is dorsolateral to the floor plate and part of the midbrain.
DHBA:12322
EFO:0003567
@@ -54050,11 +54094,11 @@ plexiform layer.
midbrain basal plate
-
+
-
+
@@ -54067,13 +54111,13 @@ plexiform layer.
-
+
EHDAA2
-
+
ZFA
@@ -54101,7 +54145,7 @@ plexiform layer.
-
+
Portion of neural tube that gives rise to the midbrain.
we follow ZFA in temporally dividing midbrain NT from presumptive midbrain, but in future this may be collapsed
TAO:0007039
@@ -54110,14 +54154,14 @@ plexiform layer.
UBERON:0010286
midbrain neural tube
-
+
-
+
ZFA
@@ -54143,9 +54187,8 @@ plexiform layer.
-
-
+
@@ -54161,14 +54204,14 @@ plexiform layer.
UBERON:0010312
immature eye
-
+
-
+
definitional
@@ -54241,7 +54284,6 @@ plexiform layer.
-
@@ -54268,7 +54310,6 @@ plexiform layer.
-
@@ -54440,8 +54481,8 @@ plexiform layer.
-
-
+
+
Anatomical cluster consisting of the skeletal elements (i.e. bone elements, cartilage elements, cartilage condensations) that are part of an individual subdivision of the organism. Excludes joints.
Anatomical cluster consisting of the skeletal elements that are part of the skeleton.[VSAO]
FMA:23879
@@ -54454,11 +54495,11 @@ plexiform layer.
subdivision of skeleton
-
+
-
+
@@ -54471,13 +54512,13 @@ plexiform layer.
-
+
UBERONREF:0000003
-
+
VSAO
@@ -54515,7 +54556,6 @@ plexiform layer.
-
@@ -54554,9 +54594,8 @@ plexiform layer.
-
-
+
Subdivision of the skeletal system which consists of the postcranial axial skeleton plus associated joints.
axial skeletal system
FMA:302077
@@ -54566,7 +54605,7 @@ plexiform layer.
postcranial axial skeletal system
http://purl.obolibrary.org/obo/uberon/docs/The-axial-skeleton
-
+
@@ -54579,7 +54618,7 @@ plexiform layer.
-
+
cjm
@@ -54691,7 +54730,7 @@ plexiform layer.
-
+
Muscles within the eye (bulbus oculi).[AAO]
AAO:0010038
EMAPA:18808
@@ -54702,14 +54741,14 @@ plexiform layer.
UBERON:0011222
intra-ocular muscle
-
+
-
+
EMAPA
@@ -54978,9 +55017,8 @@ plexiform layer.
-
-
+
@@ -55022,7 +55060,7 @@ plexiform layer.
anterior uvea
-
+
@@ -55035,7 +55073,7 @@ plexiform layer.
-
+
MP
@@ -55167,7 +55205,6 @@ plexiform layer.
-
@@ -55498,7 +55535,6 @@ plexiform layer.
-
@@ -55813,7 +55849,7 @@ plexiform layer.
-
+
@@ -55836,7 +55872,7 @@ plexiform layer.
UBERON:0016887
entire extraembryonic component
-
+
@@ -55849,7 +55885,7 @@ plexiform layer.
-
+
AEO
@@ -55871,7 +55907,6 @@ plexiform layer.
-
@@ -56464,7 +56499,6 @@ plexiform layer.
-
@@ -56603,6 +56637,196 @@ plexiform layer.
+
+
+
+
+
+
+
+
+ example to be eventually removed
+ example to be eventually removed
+
+
+
+
+
+
+
+ failed exploratory term
+ The term was used in an attempt to structure part of the ontology but in retrospect failed to do a good job
+ Person:Alan Ruttenberg
+ failed exploratory term
+
+
+
+
+
+
+
+ metadata complete
+ Class has all its metadata, but is either not guaranteed to be in its final location in the asserted IS_A hierarchy or refers to another class that is not complete.
+ metadata complete
+
+
+
+
+
+
+
+ organizational term
+ Term created to ease viewing/sort terms for development purpose, and will not be included in a release
+ organizational term
+
+
+
+
+
+
+
+ ready for release
+ Class has undergone final review, is ready for use, and will be included in the next release. Any class lacking "ready_for_release" should be considered likely to change place in hierarchy, have its definition refined, or be obsoleted in the next release. Those classes deemed "ready_for_release" will also derived from a chain of ancestor classes that are also "ready_for_release."
+ ready for release
+
+
+
+
+
+
+
+ metadata incomplete
+ Class is being worked on; however, the metadata (including definition) are not complete or sufficiently clear to the branch editors.
+ metadata incomplete
+
+
+
+
+
+
+
+ uncurated
+ Nothing done yet beyond assigning a unique class ID and proposing a preferred term.
+ uncurated
+
+
+
+
+
+
+
+ pending final vetting
+ All definitions, placement in the asserted IS_A hierarchy and required minimal metadata are complete. The class is awaiting a final review by someone other than the term editor.
+ pending final vetting
+
+
+
+
+
+
+
+ placeholder removed
+ placeholder removed
+
+
+
+
+
+
+
+ terms merged
+ An editor note should explain what were the merged terms and the reason for the merge.
+ terms merged
+
+
+
+
+
+
+
+ term imported
+ This is to be used when the original term has been replaced by a term imported from an other ontology. An editor note should indicate what is the URI of the new term to use.
+ term imported
+
+
+
+
+
+
+
+ term split
+ This is to be used when a term has been split in two or more new terms. An editor note should indicate the reason for the split and indicate the URIs of the new terms created.
+ term split
+
+
+
+
+
+
+
+ universal
+ Hard to give a definition for. Intuitively a "natural kind" rather than a collection of any old things, which a class is able to be, formally. At the meta level, universals are defined as positives, are disjoint with their siblings, have single asserted parents.
+ Alan Ruttenberg
+ A Formal Theory of Substances, Qualities, and Universals, http://ontology.buffalo.edu/bfo/SQU.pdf
+ universal
+
+
+
+
+
+
+
+ defined class
+ A defined class is a class that is defined by a set of logically necessary and sufficient conditions but is not a universal
+ "definitions", in some readings, always are given by necessary and sufficient conditions. So one must be careful (and this is difficult sometimes) to distinguish between defined classes and universal.
+ Alan Ruttenberg
+ defined class
+
+
+
+
+
+
+
+ named class expression
+ A named class expression is a logical expression that is given a name. The name can be used in place of the expression.
+ named class expressions are used in order to have more concise logical definition but their extensions may not be interesting classes on their own. In languages such as OWL, with no provisions for macros, these show up as actuall classes. Tools may with to not show them as such, and to replace uses of the macros with their expansions
+ Alan Ruttenberg
+ named class expression
+
+
+
+
+
+
+
+ to be replaced with external ontology term
+ Terms with this status should eventually replaced with a term from another ontology.
+ Alan Ruttenberg
+ group:OBI
+ to be replaced with external ontology term
+
+
+
+
+
+
+
+ requires discussion
+ A term that is metadata complete, has been reviewed, and problems have been identified that require discussion before release. Such a term requires editor note(s) to identify the outstanding issues.
+ Alan Ruttenberg
+ group:OBI
+ requires discussion
+
+
+
+
+
+
+
+
+
@@ -68,7 +75,34 @@
+ definition
+
+ The official definition, explaining the meaning of a class or property. Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions.
+ 2012-04-05:
+Barry Smith
+
+The official OBI definition, explaining the meaning of a class or property: 'Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions' is terrible.
+
+Can you fix to something like:
+
+A statement of necessary and sufficient conditions explaining the meaning of an expression referring to a class or property.
+
+Alan Ruttenberg
+
+Your proposed definition is a reasonable candidate, except that it is very common that necessary and sufficient conditions are not given. Mostly they are necessary, occasionally they are necessary and sufficient or just sufficient. Often they use terms that are not themselves defined and so they effectively can't be evaluated by those criteria.
+
+On the specifics of the proposed definition:
+
+We don't have definitions of 'meaning' or 'expression' or 'property'. For 'reference' in the intended sense I think we use the term 'denotation'. For 'expression', I think we you mean symbol, or identifier. For 'meaning' it differs for class and property. For class we want documentation that let's the intended reader determine whether an entity is instance of the class, or not. For property we want documentation that let's the intended reader determine, given a pair of potential relata, whether the assertion that the relation holds is true. The 'intended reader' part suggests that we also specify who, we expect, would be able to understand the definition, and also generalizes over human and computer reader to include textual and logical definition.
+
+Personally, I am more comfortable weakening definition to documentation, with instructions as to what is desirable.
+
+We also have the outstanding issue of how to aim different definitions to different audiences. A clinical audience reading chebi wants a different sort of definition documentation/definition from a chemistry trained audience, and similarly there is a need for a definition that is adequate for an ontologist to work with.
+ PERSON:Daniel Schober
+ GROUP:OBI:<http://purl.obolibrary.org/obo/obi>
+
definition
+ definition
@@ -76,12 +110,19 @@
+ editor note
+
+ An administrative note intended for its editor. It may not be included in the publication version of the ontology, so it should contain nothing necessary for end users to understand the ontology.
+ PERSON:Daniel Schober
+ GROUP:OBI:<http://purl.obofoundry.org/obo/obi>
IAO:0000116
uberon
editor_note
true
editor_note
+
editor note
+ editor note
@@ -106,7 +147,13 @@
-
+
+ has obsolescence reason
+ Relates an annotation property to an obsolescence reason. The values of obsolescence reasons come from a list of predefined terms, instances of the class obsolescence reason specification.
+ PERSON:Alan Ruttenberg
+ PERSON:Melanie Courtot
+ has obsolescence reason
+
@@ -119,6 +166,12 @@
+ term tracker item
+ the URI for an OBI Terms ticket at sourceforge, such as https://sourceforge.net/p/obi/obi-terms/772/
+
+ An IRI or similar locator for a request or discussion of an ontology term.
+ Person: Jie Zheng, Chris Stoeckert, Alan Ruttenberg
+ Person: Jie Zheng, Chris Stoeckert, Alan Ruttenberg
IAO:0000233
external
uberon
@@ -126,7 +179,9 @@
true
true
term_tracker_item
+ The 'tracker item' can associate a tracker with a specific ontology term.
term tracker item
+ term tracker item
@@ -134,7 +189,15 @@
+ expand expression to
+ ObjectProperty: RO_0002104
+Label: has plasma membrane part
+Annotations: IAO_0000424 "http://purl.obolibrary.org/obo/BFO_0000051 some (http://purl.org/obo/owl/GO#GO_0005886 and http://purl.obolibrary.org/obo/BFO_0000051 some ?Y)"
+
+ A macro expansion tag applied to an object property (or possibly a data property) which can be used by a macro-expansion engine to generate more complex expressions from simpler ones
+ Chris Mungall
expand expression to
+ expand expression to
@@ -166,12 +229,16 @@
+ has ontology root term
+ Ontology annotation property. Relates an ontology to a term that is a designated root term of the ontology. Display tools like OLS can use terms annotated with this property as the starting point for rendering the ontology class hierarchy. There can be more than one root.
+ Nicolas Matentzoglu
IAO:0000700
uberon
has_ontology_root_term
true
has_ontology_root_term
has ontology root term
+ has ontology root term
preferred_root
@@ -186,7 +253,14 @@
+ term replaced by
+
+ Use on obsolete terms, relating the term to another term that can be used as a substitute
+ Person:Alan Ruttenberg
+ Person:Alan Ruttenberg
+ Add as annotation triples in the granting ontology
term replaced by
+ term replaced by
@@ -512,6 +586,12 @@ WHERE {
+
+
+
+
+
+
@@ -1060,6 +1140,7 @@ WHERE {
+ a mis-spelling that is in common use and thus recorded
@@ -1876,6 +1957,12 @@ WHERE {
+
+
+
+
+
+
+
+
+ This document is about information artifacts and their representations
+
+ A (currently) primitive relation that relates an information artifact to an entity.
+ 7/6/2009 Alan Ruttenberg. Following discussion with Jonathan Rees, and introduction of "mentions" relation. Weaken the is_about relationship to be primitive.
+
+We will try to build it back up by elaborating the various subproperties that are more precisely defined.
+
+Some currently missing phenomena that should be considered "about" are predications - "The only person who knows the answer is sitting beside me" , Allegory, Satire, and other literary forms that can be topical without explicitly mentioning the topic.
+ person:Alan Ruttenberg
+ Smith, Ceusters, Ruttenberg, 2000 years of philosophy
+ is about
+
+
+
+
@@ -2743,6 +2850,7 @@ range: spatial region or site (immaterial continuant)
located_in
located in
located in
+ https://wiki.geneontology.org/Located_in
@@ -2810,7 +2918,7 @@ range: spatial region or site (immaterial continuant)
-
+
@@ -2873,7 +2981,7 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
A 'has regulatory component activity' B if A and B are GO molecular functions (GO_0003674), A has_component B and A is regulated by B.
- dos
+
2017-05-24T09:30:46Z
RO:0002013
external
@@ -2890,7 +2998,7 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
A relationship that holds between a GO molecular function and a component of that molecular function that negatively regulates the activity of the whole. More formally, A 'has regulatory component activity' B iff :A and B are GO molecular functions (GO_0003674), A has_component B and A is negatively regulated by B.
- dos
+
2017-05-24T09:31:01Z
RO:0002014
external
@@ -2908,7 +3016,7 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
A relationship that holds between a GO molecular function and a component of that molecular function that positively regulates the activity of the whole. More formally, A 'has regulatory component activity' B iff :A and B are GO molecular functions (GO_0003674), A has_component B and A is positively regulated by B.
- dos
+
2017-05-24T09:31:17Z
By convention GO molecular functions are classified by their effector function and internal regulatory functions are treated as components. So, for example calmodulin has a protein binding activity that has positive regulatory component activity calcium binding activity. Receptor tyrosine kinase activity is a tyrosine kinase activity that has positive regulatory component 'ligand binding'.
has positive regulatory component activity
@@ -2920,7 +3028,7 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
- dos
+
2017-05-24T09:44:33Z
A 'has component activity' B if A is A and B are molecular functions (GO_0003674) and A has_component B.
has component activity
@@ -2935,7 +3043,7 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
w 'has process component' p if p and w are processes, w 'has part' p and w is such that it can be directly disassembled into into n parts p, p2, p3, ..., pn, where these parts are of similar type.
- dos
+
2017-05-24T09:49:21Z
has component process
@@ -2947,7 +3055,7 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
A relationship between a process and a barrier, where the process occurs in a region spanning the barrier. For cellular processes the barrier is typically a membrane. Examples include transport across a membrane and membrane depolarization.
- dos
+
2017-07-20T17:19:37Z
occurs across
@@ -2959,7 +3067,7 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
- dos
+
2017-09-17T13:52:24Z
Process(P2) is directly regulated by process(P1) iff: P1 regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding regulates the kinase activity (P2) of protein B then P1 directly regulates P2.
directly regulated by
@@ -2968,7 +3076,7 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
Process(P2) is directly regulated by process(P1) iff: P1 regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding regulates the kinase activity (P2) of protein B then P1 directly regulates P2.
- GOC:dos
+
@@ -2979,7 +3087,7 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
Process(P2) is directly negatively regulated by process(P1) iff: P1 negatively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding negatively regulates the kinase activity (P2) of protein B then P2 directly negatively regulated by P1.
- dos
+
2017-09-17T13:52:38Z
directly negatively regulated by
@@ -2987,7 +3095,7 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
Process(P2) is directly negatively regulated by process(P1) iff: P1 negatively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding negatively regulates the kinase activity (P2) of protein B then P2 directly negatively regulated by P1.
- GOC:dos
+
@@ -2998,7 +3106,7 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
Process(P2) is directly postively regulated by process(P1) iff: P1 positively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding positively regulates the kinase activity (P2) of protein B then P2 is directly postively regulated by P1.
- dos
+
2017-09-17T13:52:47Z
directly positively regulated by
@@ -3006,7 +3114,7 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
Process(P2) is directly postively regulated by process(P1) iff: P1 positively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding positively regulates the kinase activity (P2) of protein B then P2 is directly postively regulated by P1.
- GOC:dos
+
@@ -3017,7 +3125,7 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
A 'has effector activity' B if A and B are GO molecular functions (GO_0003674), A 'has component activity' B and B is the effector (output function) of B. Each compound function has only one effector activity.
- dos
+
2017-09-22T14:14:36Z
This relation is designed for constructing compound molecular functions, typically in combination with one or more regulatory component activity relations.
has effector activity
@@ -3026,7 +3134,7 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
A 'has effector activity' B if A and B are GO molecular functions (GO_0003674), A 'has component activity' B and B is the effector (output function) of B. Each compound function has only one effector activity.
- GOC:dos
+
@@ -3048,7 +3156,9 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
+
+ x simultaneous with y iff ω(x) = ω(y) and ω(α ) = ω(α), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point and '=' indicates the same instance in time.
David Osumi-Sutherland
RO:0002082
@@ -3129,14 +3239,14 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
-
+
+ Relation between a neuron and a material anatomical entity that its soma is part of.
Relation between a neuron and an anatomical structure that its soma is part of.
- Relation between a neuron and an anatomical structure that its soma is part of.
<http://purl.obolibrary.org/obo/BFO_0000051> some (
<http://purl.obolibrary.org/obo/GO_0043025> and <http://purl.obolibrary.org/obo/BFO_0000050> some ?Y)
@@ -3274,8 +3384,8 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
-
-
+
+
Every B cell[CL_0000236] has plasma membrane part some immunoglobulin complex[GO_0019814]
Holds between a cell c and a protein complex or protein p if and only if that cell has as part a plasma_membrane[GO:0005886], and that plasma membrane has p as part.
@@ -3624,7 +3734,6 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.
-
@@ -3801,8 +3910,8 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.
-
-
+
+
@@ -3934,7 +4043,7 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.
-
+
@@ -3956,16 +4065,16 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.
-
+
-
+
@@ -4326,7 +4435,7 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.
-
+
@@ -4464,6 +4573,7 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.has_input
has input
has input
+ https://wiki.geneontology.org/Has_input
@@ -4491,6 +4601,7 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.has_output
has output
has output
+ https://wiki.geneontology.org/Has_output
@@ -4500,8 +4611,8 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.
-
-
+
+
@@ -4543,8 +4654,8 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.
-
-
+
+
t1 induced_by t2 if there is a process of developmental induction (GO:0031128) with t1 and t2 as interacting participants. t2 causes t1 to change its fate from a precursor material anatomical entity type T to T', where T' develops_from T
@@ -4626,7 +4737,7 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.affects
acts upstream of or within
-
+ https://wiki.geneontology.org/Acts_upstream_of_or_within
@@ -4683,7 +4794,7 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.
- Inverse of 'expressed in'
+ y expresses x if and only if there is a gene expression process (GO:0010467) that occurs in y, and one of the following holds: (i) x is a gene, and x is transcribed into a transcript as part of the gene expression process (ii) x is a transcript, and x was transcribed from a gene as part of the gene expression process (iii) x is a mature gene product (protein or RNA), and x was translated or otherwise processed from a transcript that was transcribed as part of the gene expression process.
expresses
@@ -4695,7 +4806,7 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.
-
+
p results in the developmental progression of s iff p is a developmental process and s is an anatomical entity and p causes s to undergo a change in state at some point along its natural developmental cycle (this cycle starts with its formation, through the mature structure, and ends with its loss).
This property and its subproperties are being used primarily for the definition of GO developmental processes. The property hierarchy mirrors the core GO hierarchy. In future we may be able to make do with a more minimal set of properties, but due to the way GO is currently structured we require highly specific relations to avoid incorrect entailments. To avoid this, the corresponding genus terms in GO should be declared mutually disjoint.
@@ -4822,6 +4933,7 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.causally_upstream_of,_positive_effect
holds between x and y if and only if x is causally upstream of y and the progression of x increases the frequency, rate or extent of y
causally upstream of, positive effect
+
@@ -4841,6 +4953,7 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.
causally_upstream_of,_negative_effect
causally upstream of, negative effect
+
@@ -4883,7 +4996,7 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.
-
+
an annotation of gene X to cell differentiation with results_in_maturation_of CL:0000057 (fibroblast) means that at the end of the process the input cell that did not have features of a fibroblast, now has the features of a fibroblast.
The relationship that links a specified entity with the process that results in an unspecified entity acquiring the features and characteristics of the specified entity
@@ -4959,6 +5072,7 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.This relation differs from the parent relation 'capable of' in that the parent is weaker and only expresses a capability that may not be actually realized, whereas this relation is always realized.
enables
+ https://wiki.geneontology.org/Enables
@@ -5035,7 +5149,7 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.actively involved in
enables part of
involved in
-
+ https://wiki.geneontology.org/Involved_in
@@ -5070,6 +5184,7 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.
enabled by
+ https://wiki.geneontology.org/Enabled_by
@@ -5374,7 +5489,7 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.
-
+
m has_muscle_origin s iff m is attached_to s, and it is the case that when m contracts, s does not move. The site of the origin tends to be more proximal and have greater mass than what the other end attaches to.
Wikipedia:Insertion_(anatomy)
@@ -5389,7 +5504,7 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.
-
+
We need to import uberon muscle to create a stricter domain constraint
@@ -5400,7 +5515,7 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.
-
+
m has_muscle_insertion s iff m is attaches_to s, and it is the case that when m contracts, s moves. Insertions are usually connections of muscle via tendon to bone.
Wikipedia:Insertion_(anatomy)
@@ -5415,7 +5530,7 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.
-
+
We need to import uberon muscle into RO to use as a stricter domain constraint
@@ -5514,8 +5629,8 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.
-
-
+
+
x has developmental potential involving y iff x is capable of a developmental process with output y. y may be the successor of x, or may be a different structure in the vicinity (as for example in the case of developmental induction).
@@ -5646,6 +5761,7 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.indirectly activates
indirectly positively regulates
+ https://wiki.geneontology.org/Indirectly_positively_regulates
@@ -5673,6 +5789,7 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.indirectly inhibits
indirectly negatively regulates
+ https://wiki.geneontology.org/Indirectly_negatively_regulates
@@ -5876,6 +5993,7 @@ Each of these 3 primitives can be composed to yield a cross-product of different
enables activity in
is active in
+ https://wiki.geneontology.org/Is_active_in
@@ -5890,8 +6008,8 @@ Each of these 3 primitives can be composed to yield a cross-product of different
c executes activity in d if and only if c enables p and p occurs_in d. Assuming no action at a distance by gene products, if a gene product enables (is capable of) a process that occurs in some structure, it must have at least some part in that structure.
- GOC:cjm
- GOC:dos
+
+
@@ -6402,9 +6520,9 @@ For example, A and B may be gene products and binding of B by A positively regul
-
+
-
+
Forelimb SubClassOf has_skeleton some 'Forelimb skeleton'
A relation between a segment or subdivision of an organism and the maximal subdivision of material entities that provides structural support for that segment or subdivision.
@@ -6420,7 +6538,7 @@ For example, A and B may be gene products and binding of B by A positively regul
-
+
This should be to a more restricted class, but not the Uberon class may be too restricted since it is a composition-based definition of skeleton rather than functional.
@@ -6510,8 +6628,8 @@ For example, A and B may be gene products and binding of B by A positively regul
-
-
+
+
A relation that holds between elements of a musculoskeletal system or its analogs.
Do not use this relation directly. It is ended as a grouping for a diverse set of relations, all involving the biomechanical processes.
@@ -6582,7 +6700,7 @@ For example, A and B may be gene products and binding of B by A positively regul
x lumen_of y iff x is the space or substance that is part of y and does not cross any of the inner membranes or boundaries of y that is maximal with respect to the volume of the convex hull.
- GOC:cjm
+
RO:0002571
uberon
lumen_of
@@ -6614,8 +6732,8 @@ For example, A and B may be gene products and binding of B by A positively regul
-
-
+
+
inverse of has skeleton
RO:0002576
@@ -6800,6 +6918,16 @@ For example, A and B may be gene products and binding of B by A positively regul
+
+
+
+ A relationship that holds between two entities, where the entities exhibit a statistical dependence relationship. The entities may be statistical variables, or they may be other kinds of entities such as diseases, chemical entities or processes.
+ Groups both positive and negative correlation
+ correlated with
+
+
+
+
@@ -6817,6 +6945,7 @@ For example, A and B may be gene products and binding of B by A positively regul
directly_positively_regulates
directly positively regulates
+ https://wiki.geneontology.org/Directly_positively_regulates
@@ -6838,6 +6967,7 @@ For example, A and B may be gene products and binding of B by A positively regul
directly_negatively_regulates
directly negatively regulates
+ https://wiki.geneontology.org/Directly_negatively_regulates
@@ -6926,7 +7056,7 @@ For example, A and B may be gene products and binding of B by A positively regul
p has primary output c if (a) p has output c and (b) the goal of process is to modify, produce, or transform c.
- GOC:cjm
+
GOC:dph
GOC:kva
GOC:pt
@@ -6954,7 +7084,7 @@ For example, A and B may be gene products and binding of B by A positively regul
p has primary input c if (a) p has input c and (b) the goal of process is to modify, consume, or transform c.
- GOC:cjm
+
GOC:dph
GOC:kva
GOC:pt
@@ -6992,7 +7122,7 @@ For example, A and B may be gene products and binding of B by A positively regul
2018-01-26T23:49:30Z
acts upstream of or within, positive effect
-
+ https://wiki.geneontology.org/Acts_upstream_of_or_within,_positive_effect
@@ -7010,6 +7140,7 @@ For example, A and B may be gene products and binding of B by A positively regul
2018-01-26T23:49:51Z
acts upstream of or within, negative effect
+ https://wiki.geneontology.org/Acts_upstream_of_or_within,_negative_effect
@@ -7029,7 +7160,7 @@ For example, A and B may be gene products and binding of B by A positively regul
2018-01-26T23:53:14Z
acts upstream of, positive effect
-
+ https://wiki.geneontology.org/Acts_upstream_of,_positive_effect
@@ -7049,7 +7180,7 @@ For example, A and B may be gene products and binding of B by A positively regul
2018-01-26T23:53:22Z
acts upstream of, negative effect
-
+ https://wiki.geneontology.org/Acts_upstream_of,_negative_effect
@@ -7062,6 +7193,7 @@ For example, A and B may be gene products and binding of B by A positively regul
2018-03-13T23:55:05Z
causally upstream of or within, negative effect
+ https://wiki.geneontology.org/Causally_upstream_of_or_within,_negative_effect
@@ -7074,6 +7206,7 @@ For example, A and B may be gene products and binding of B by A positively regul
2018-03-13T23:55:19Z
causally upstream of or within, positive effect
+
@@ -7096,7 +7229,7 @@ For example, A and B may be gene products and binding of B by A positively regul
p acts on population of c iff c' is a collection, has members of type c, and p has participant c
- pg
+
2020-06-08T17:21:33Z
RO:0012003
external
@@ -7115,7 +7248,7 @@ For example, A and B may be gene products and binding of B by A positively regul
- pg
+
2021-02-26T07:28:29Z
RO:0012008
external
@@ -7135,7 +7268,7 @@ For example, A and B may be gene products and binding of B by A positively regul
p is indirectly causally upstream of q iff p is causally upstream of q and there exists some process r such that p is causally upstream of r and r is causally upstream of q.
- pg
+
2022-09-26T06:07:17Z
indirectly causally upstream of
@@ -7148,7 +7281,7 @@ For example, A and B may be gene products and binding of B by A positively regul
p indirectly regulates q iff p is indirectly causally upstream of q and p regulates q.
- pg
+
2022-09-26T06:08:01Z
indirectly regulates
@@ -7164,7 +7297,7 @@ For example, A and B may be gene products and binding of B by A positively regul
A relationship between a neuron and a region, where the neuron has a functionally relevant number of input and/or output synapses in that region.
-
+
2020-07-17T09:26:52Z
has synaptic input or output in
has synaptic IO in region
@@ -7182,7 +7315,7 @@ For example, A and B may be gene products and binding of B by A positively regul
Relation between a sensory neuron and some structure in which it receives sensory input via a sensory dendrite.
-
+
2020-07-20T12:10:09Z
has sensory dendrite location
has sensory terminal in
@@ -7278,8 +7411,8 @@ For example, A and B may be gene products and binding of B by A positively regul
'Ly-76 high positive erythrocyte' equivalent to 'enucleate erythrocyte' and (has_high_plasma_membrane_amount some 'lymphocyte antigen 76 (mouse)')
A relation between a cell and molecule or complex such that every instance of the cell has a high number of instances of that molecule expressed on the cell surface.
-
-
+
+
has high plasma membrane amount
@@ -7298,8 +7431,8 @@ For example, A and B may be gene products and binding of B by A positively regul
'DN2b thymocyte' equivalent to 'DN2 thymocyte' and (has_low_plasma_membrane_amount some 'mast/stem cell growth factor receptor')
A relation between a cell and molecule or complex such that every instance of the cell has a low number of instances of that molecule expressed on the cell surface.
-
-
+
+
has low plasma membrane amount
@@ -7331,6 +7464,20 @@ For example, A and B may be gene products and binding of B by A positively regul
+
+
+
+
+
+
+ A relation between entities in which one increases or decreases as the other does the same.
+ directly correlated with
+
+ positively correlated with
+
+
+
+
@@ -7802,7 +7949,8 @@ For example, A and B may be gene products and binding of B by A positively regul
- A continuant that is a bearer of quality and realizable entity entities, in which other entities inhere and which itself cannot inhere in anything.
+ b is an independent continuant = Def. b is a continuant which is such that there is no c and no t such that b s-depends_on c at t. (axiom label in BFO2 Reference: [017-002])
+ A continuant that is a bearer of quality and realizable entity entities, in which other entities inhere and which itself cannot inhere in anything.
independent continuant
@@ -7812,7 +7960,8 @@ For example, A and B may be gene products and binding of B by A positively regul
- An occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t.
+ p is a process = Def. p is an occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t. (axiom label in BFO2 Reference: [083-003])
+ An occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t.
process
@@ -7828,7 +7977,8 @@ For example, A and B may be gene products and binding of B by A positively regul
- A continuant that inheres in or is borne by other entities. Every instance of A requires some specific instance of B which must always be the same.
+ b is a specifically dependent continuant = Def. b is a continuant & there is some independent continuant c which is not a spatial region and which is such that b s-depends_on c at every time t during the course of b’s existence. (axiom label in BFO2 Reference: [050-003])
+ A continuant that inheres in or is borne by other entities. Every instance of A requires some specific instance of B which must always be the same.
specifically dependent continuant
@@ -8462,7 +8612,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -8769,7 +8918,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -9005,7 +9153,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -9145,7 +9292,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -9230,7 +9376,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -9430,7 +9575,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -9533,7 +9677,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -9744,7 +9887,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -10686,7 +10828,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -11099,7 +11240,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -11240,7 +11380,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -11308,7 +11447,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -11547,7 +11685,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -11683,7 +11820,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -11837,7 +11973,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -12068,7 +12203,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -12380,7 +12514,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -12709,7 +12842,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -13138,7 +13270,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -13183,7 +13314,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -13229,7 +13359,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -13634,7 +13763,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -13908,7 +14036,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -25737,6 +25864,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PR:000001006
Category=gene. Requested by=CL.
receptor-type tyrosine-protein phosphatase C
+
@@ -25786,6 +25914,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PR:000001012
Category=gene. Requested by=CL.
integrin alpha-M
+
@@ -25832,6 +25961,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PR:000001013
Category=gene. Requested by=CL.
integrin alpha-X
+
@@ -25866,6 +25996,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PR:000001015
Category=sequence. Requested by=CL. Note: This isoform includes the region encoded by the variable exon 4(A), and lacks the region encoded by exons 5(B) and 6(C).
receptor-type tyrosine-protein phosphatase C isoform CD45RA
+
@@ -25999,6 +26130,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PR:000001024
Category=gene. Requested by=CL.
neural cell adhesion molecule 1
+
@@ -26083,6 +26215,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PR:000001084
Category=gene. Requested by=CL.
T-cell surface glycoprotein CD8 alpha chain
+
@@ -26212,6 +26345,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PR:000001332
Category=gene. Requested by=CL.
carcinoembryonic antigen-related cell adhesion molecule 8
+
@@ -26274,6 +26408,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PR:000001381
Category=gene. Requested by=CL.
interleukin-2 receptor subunit beta
+
@@ -26317,6 +26452,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PR:000001444
Category=gene. Requested by=CL.
cadherin-5
+
@@ -26438,6 +26574,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PR:000001839
Category=gene. Requested by=CL.
T-cell surface glycoprotein CD5
+
@@ -26477,6 +26614,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PR:000001850
Category=gene. Requested by=CL.
cathepsin K
+
@@ -26573,6 +26711,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PR:000001869
Category=gene. Requested by=CL.
interleukin-7 receptor subunit alpha
+
@@ -26629,6 +26768,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PR:000001879
Category=gene. Requested by=CL.
leukosialin
+
@@ -26705,6 +26845,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PR:000001898
Category=gene. Requested by=CL.
neprilysin
+
@@ -26741,6 +26882,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PR:000001903
Category=gene. Requested by=CL.
paired box protein PAX-5
+
@@ -26781,6 +26923,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PR:000001937
Category=gene. Requested by=CL.
tartrate-resistant acid phosphatase type 5
+
@@ -26824,6 +26967,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PR:000001944
Category=gene. Requested by=CL.
transcription factor PU.1
+
@@ -26870,6 +27014,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PR:000001954
Category=gene. Requested by=CL.
tumor necrosis factor receptor superfamily member 11A
+
@@ -26910,6 +27055,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PR:000001969
Category=gene. Requested by=CL.
urokinase plasminogen activator surface receptor
+
@@ -26979,6 +27125,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PR:000002062
Category=gene. Requested by=CL.
macrophage colony-stimulating factor 1 receptor
+
@@ -27074,6 +27221,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PR:000002112
Category=gene. Requested by=CL.
vascular endothelial growth factor receptor 2
+
@@ -27194,6 +27342,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PR:000005307
Category=gene. Requested by=CL.
CCAAT/enhancer-binding protein alpha
+
@@ -27231,6 +27380,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PR:000006611
Category=gene. Requested by=CL.
DNA nucleotidylexotransferase
+
@@ -27269,6 +27419,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PR:000007597
Category=gene. Requested by=CL.
protein c-Fos
+
@@ -27309,6 +27460,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PR:000007857
Category=gene. Requested by=CL.
erythroid transcription factor
+
@@ -27349,6 +27501,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PR:000007858
Category=gene. Requested by=CL.
endothelial transcription factor GATA-2
+
@@ -27383,6 +27536,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PR:000011178
Category=gene. Requested by=CL.
nuclear factor NF-kappa-B p100 subunit
+
@@ -27420,6 +27574,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PR:000014841
Category=gene.
sonic hedgehog protein
+
@@ -27461,6 +27616,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PR:000016043
Category=gene. Requested by=CL.
T-cell acute lymphocytic leukemia protein 1
+
@@ -29237,6 +29393,8 @@ MH: sexual subtypes should probably be logically defined based on sexual process
Staged defined by the formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system.
+
+ In zebrafish, the times of neurulation and segmentation overlap so extensively there is no distinct neurula period of development, such as occurs largely before segmentation in amphibian embryos.
BILS:0000110
BilaDO:0000009
HsapDv:0000012
@@ -29245,6 +29403,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
uberon
UBERON:0000110
neurula stage
+ https://github.com/obophenotype/developmental-stage-ontologies/issues/84
https://github.com/obophenotype/uberon/issues/343
@@ -29267,12 +29426,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
-
-
-
-
-
@@ -29297,6 +29450,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
segmentation stage
UBERON:0000111
organogenesis stage
+ https://github.com/obophenotype/developmental-stage-ontologies/issues/84
https://github.com/obophenotype/uberon/issues/533
@@ -29369,7 +29523,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -29383,7 +29536,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
@@ -29456,7 +29609,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
https://github.com/obophenotype/uberon/issues/661
http://upload.wikimedia.org/wikipedia/commons/0/06/Mouth_illustration-Otis_Archives.jpg
-
+
@@ -29469,7 +29622,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
exceptions in some taxa
@@ -29597,7 +29750,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -29663,7 +29815,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -29780,7 +29931,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
@@ -29822,14 +29973,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
organism substance
-
+
-
+
this relationship may be too strong and may be weakened in future
@@ -31061,7 +31212,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
Primary germ layer that is the outer of the embryo's three germ layers and gives rise to epidermis and neural tissue.
Primary germ layer that is the outer of the embryonic germ layers and gives rise to epidermis and neural tissue.[AAO]
The Bilateria are triploblastic (with true endoderm, mesoderm, and ectoderm) (...).[well established][VHOG]
@@ -31099,14 +31250,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
ectoderm
http://upload.wikimedia.org/wikipedia/commons/1/19/Gray32.png
-
+
-
+
Bgee:AN
@@ -31159,7 +31310,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
Primary germ layer that lies remote from the surface of the embryo and gives rise to internal tissues such as gut.
The Bilateria are triploblastic (with true endoderm, mesoderm, and ectoderm) (...).[well established][VHOG]
endodermal
@@ -31196,14 +31347,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
http://upload.wikimedia.org/wikipedia/commons/c/c0/Endoderm2.png
http://upload.wikimedia.org/wikipedia/commons/d/df/Gray10.png
-
+
-
+
Bgee:AN
@@ -31248,7 +31399,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
The middle germ layer of the embryo, between the endoderm and ectoderm.
Primary germ layer that is the middle of the embryonic germ layers.[AAO]
@@ -31293,7 +31444,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
mesoderm
http://upload.wikimedia.org/wikipedia/commons/e/e8/Mesoderm.png
-
+
@@ -31306,7 +31457,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
Bgee:AN
@@ -31629,8 +31780,8 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
-
+
+
@@ -31666,24 +31817,24 @@ MH: sexual subtypes should probably be logically defined based on sexual process
eye
-
+
-
+
-
+
PMID:21062451
-
+
PMID:21062451
@@ -32166,7 +32317,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -32260,7 +32410,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -32292,7 +32441,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
@@ -32347,14 +32496,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
http://upload.wikimedia.org/wikipedia/commons/b/b2/TE-Nervous_system_diagram.svg
http://upload.wikimedia.org/wikipedia/commons/b/ba/Nervous_system_diagram.png
-
+
-
+
Bgee:AN
@@ -32442,7 +32591,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the neural tube derivatives: the brain and spinal cord. In invertebrates it includes central ganglia plus nerve cord.
Part of the nervous system which includes the brain and spinal cord.[AAO]
@@ -32489,7 +32638,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
central nervous system
-
+
@@ -32503,7 +32652,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
Bgee:AN
@@ -33370,7 +33519,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
Skeletal element that is composed of bone tissue.
@@ -33420,14 +33569,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
bone element
-
+
-
+
VSAO-modified
@@ -33519,7 +33668,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -33539,7 +33687,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
A tube extending from the mouth to the anus.
@@ -33579,14 +33727,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
digestive tract
-
+
-
+
NCBIBook:NBK10107
@@ -34158,7 +34306,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -34178,7 +34325,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
@@ -34214,14 +34361,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
musculoskeletal system
-
+
-
+
check ctenophore
@@ -34284,9 +34431,9 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
-
-
+
+
+
@@ -34341,15 +34488,15 @@ MH: sexual subtypes should probably be logically defined based on sexual process
notochord
http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png
-
+
-
+
-
+
@@ -34368,19 +34515,19 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
http://tolweb.org/Chordata/2499
-
+
ZFA
-
+
EHDAA2
@@ -34463,11 +34610,10 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
-
-
+
+
Somites are spheres of epithelial cells that form sequentially along the anterior-posterior axis of the embryo through mesenchymal to epithelial transition of the presomitic mesoderm.
currently classified as an epithelial vesicle, consistent with EHDAA2 and https://github.com/obophenotype/uberon/wiki/The-neural-crest. Consider making 'somitic mesoderm' a separate term and correlate with regionalization processes. Consider moving ZFA term to 'trunk somite' as it is part of the trunk
@@ -34513,11 +34659,11 @@ MH: sexual subtypes should probably be logically defined based on sexual process
somite
http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png
-
+
-
+
@@ -34530,13 +34676,13 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
GOTAX:0000352
-
+
ZFA
@@ -34713,12 +34859,12 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
-
-
-
-
-
+
+
+
+
+
+
A specialized region of ectoderm found between the neural ectoderm (neural plate) and non-neural ectoderm and composed of highly migratory pluripotent cells that delaminate in early embryonic development from the dorsal neural tube and give rise to an astounding variety of differentiated cell types[MP].
consider including subclasses for pre- and post- migratory (e.g. sheets/paths/streams).
@@ -34758,66 +34904,66 @@ MH: sexual subtypes should probably be logically defined based on sexual process
http://upload.wikimedia.org/wikipedia/commons/5/5f/Gray644.png
https://upload.wikimedia.org/wikipedia/commons/8/8f/Neural_Crest.png
-
+
-
+
-
+
-
+
-
+
-
+
-
+
XAO
https://github.com/obophenotype/uberon/wiki/The-neural-crest
-
+
Hall and others restrict NC to vertebrates but we opt for a less restrictive constraint to avoid inconsistencies when areas such as P1 area of pallium in hagfishes inherit cell lineage from telecephalon-contributing NC cells
ISBN:0073040584
-
+
BTO
-
+
PMID:11523831
-
+
pre migratory https://github.com/obophenotype/uberon/wiki/The-neural-crest
-
+
PMID:11523831
@@ -35172,7 +35318,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
@@ -35230,14 +35376,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
bone marrow
http://upload.wikimedia.org/wikipedia/commons/7/74/Gray72-en.svg
-
+
-
+
FMA
MA
@@ -35506,17 +35652,16 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
-
+
-
+
Anatomical system that is involved in the production of hematopoietic cells.
@@ -35560,24 +35705,24 @@ MH: sexual subtypes should probably be logically defined based on sexual process
hematopoietic system
-
+
-
+
-
+
FMA
-
+
definitional
@@ -36043,7 +36188,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
Unsegmented field of paraxial mesoderm present posterior to the most recently formed somite pair, from which somites will form.
Unsegmented field of paraxial mesoderm present posterior to the most recently formed somite pair, from which somites will form. Kimmel et al, 1995.[TAO]
It is reasonable to assume that the proximate invertebrate ancestor of the vertebrates had an amphioxus-like tail bud in its larval stage. This archetypal tail bud would have (...) (3) lacked any component of mesenchyme cells, (4) budded off new mesodermal segments directly, without any intervening zone of presomitic mesoderm (...). Then, early in vertebrate evolution, epithelium-to-mesenchyme interconversions (and the gene networks for effecting them) became prominent features of development. (...) In any case, conspicuous mesenchymal components tended to be added to the vertebrate tail bud itself. In addition, a mesenchymatous presomitic mesoderm (not a part of the tail bud proper) came to intervene between the tail bud and the forming somites.[well established][VHOG]
@@ -36068,14 +36213,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
presomitic mesoderm
-
+
-
+
Bgee:AN
@@ -36238,7 +36383,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -36303,13 +36447,12 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
-
-
-
+
+
+
A region of embryonic ectodermal cells that lie directly above the notochord. During neurulation, they change shape and produce an infolding of the neural plate (the neural fold) that then seals to form the neural tube[XAO]. The earliest recognizable dorsal ectodermal primordium of the central nervous system present near the end of gastrulation before infolding to form the neural keel; consists of a thickened pseudostratified epithelium[ZFA].
The earliest recognizable dorsal ectodermal primordium of the central nervous system present near the end of gastrulation before infolding to form the neural keel; consists of a thickened pseudostratified epithelium. Kimmel et al, 1995.[TAO]
(...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...).[well established][VHOG]
@@ -36341,34 +36484,34 @@ MH: sexual subtypes should probably be logically defined based on sexual process
neural plate
https://upload.wikimedia.org/wikipedia/commons/8/8f/Neural_Crest.png
-
+
-
+
-
+
-
+
GOTAX:0000352
-
+
Wikipedia
-
+
Bgee:AN
@@ -36433,7 +36576,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
The paraxial mesoderm is the mesoderm located bilaterally adjacent to the notochord and neural tube[GO].
Mesoderm lateral to the neural tube and notochord that is divided into cranial and post-cranial portions. The trunk portions further segment into somites.[AAO]
Presently, Cephalochordata, Urochordata, and Vertebrata are placed as subphyla of the phylum Chordata, in which the overall organization of embryonic tissues (dorsal hollow nerve cord, ventral digestive tract, axial notochord, and bilateral paraxial mesoderm) is largely conserved. In contrast, the echinoderms and hemichordates are sister groups of the chordates and they lack the notochord and paraxial mesoderm. Thus, the basic mesodermal organization of vertebrates must have appeared first in the common ancestor of the chordates.[well established][VHOG]
@@ -36462,7 +36605,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
paraxial mesoderm
http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png
-
+
@@ -36475,7 +36618,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
Bgee:AN
@@ -36547,7 +36690,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
@@ -36591,7 +36734,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
lateral plate mesoderm
http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png
-
+
@@ -36604,7 +36747,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
EHDAA2
VHOG
@@ -36687,9 +36830,8 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
-
+
@@ -36732,7 +36874,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
myotome
http://upload.wikimedia.org/wikipedia/commons/9/96/Gray65.png
-
+
@@ -36745,7 +36887,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
EHDAA2-abduced
@@ -36801,8 +36943,8 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
-
+
+
Ventral somitic compartment that is a precursor of the axial skeleton[XAO]. Sclerotomes eventually differentiate into the vertebrae and most of the skull. The caudal (posterior) half of one sclerotome fuses with the rostral (anterior) half of the adjacent one to form each vertebra. From their initial location within the somite, the sclerotome cells migrate medially towards the notochord. These cells meet the sclerotome cells from the other side to form the vertebral body. From this vertebral body, sclerotome cells move dorsally and surround the developing spinal cord, forming the vertebral arch[WP].
Skeletogenic portion of somites.[AAO]
The vertebrate sclerotome has no equivalent in amphioxus and is a novelty linked with the evolution of the axial skeleton.[well established][VHOG]
@@ -36829,11 +36971,11 @@ MH: sexual subtypes should probably be logically defined based on sexual process
sclerotome
http://upload.wikimedia.org/wikipedia/commons/9/96/Gray65.png
-
+
-
+
@@ -36852,13 +36994,13 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
VHOG:0000680
-
+
ZFA
@@ -37060,7 +37202,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -37068,7 +37209,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
The part of the coelom in the embryo between the somatopleuric and splanchnopleuric mesoderm; the principal body cavities of the trunk (thoracic, abdominal, and pelvic) arise from this embryonic part of the coelom.
consider merging with coelom. TODO - add spatial relationships to halves of LPM. Note the OG places XAO and ZFA coelem terms here. editor note: TODO check ZFA, which appears to be a structure present in adults
(...) I regard it unlikely that coeloms of all bilaterian animals are comparable and evolved very early. Considering all these questions, few convincing characters concerning the evolution of body cavities remain to be named. (...) A segmental coelom appears to have evolved at least two times, in Annelida and in Myomerata (Acrania and Craniota).[well established][VHOG]
@@ -37084,14 +37225,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
intraembryonic coelom
-
+
-
+
Wikipedia
@@ -37268,7 +37409,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -37313,7 +37453,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -37413,7 +37552,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -37422,7 +37560,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
The bilaminar epithelium formed from the myotome and dermatome.
Epithelial sheet on the external surface of the somite that gives rise to trunk, muscle and dermis. Within the dermomyotome there is also a medio-lateral difference. The central region makes dermis, the mesenchymal connective tissue of the back skin. The medial region (closest to neural tube) makes epaxial muscle, and the lateral region (furthest from neural tube) makes hypaxial muscle[http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=eurekah&part=A66768].
Epithelial sheet on the external surface of the somite that gives rise to trunk, muscle and dermis.[TAO]
@@ -37445,7 +37583,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
UBERON:0004290
dermomyotome
-
+
@@ -37464,7 +37602,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
EHDAA2
ZFA
@@ -37579,7 +37717,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -37656,7 +37793,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -37785,7 +37921,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -37793,7 +37928,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
A specialized form of connective tissue in which the extracellular matrix is firm, providing the tissue with resilience, and/or mineralized and that functions in mechanical and structural support.[VSAO].
A specialized form of connective tissue in which the extracellular matrix is firm, providing the tissue with resilience, and/or mineralized and that functions in mechanical and structural support.[VSAO]
EMAPA:37744
@@ -37807,7 +37942,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
Four classes of mineralized tissues are found in vertebrates: bone, cartilage, dentine, and enamel. We think of cartilage and bone as skeletal tissues and of enamel and dentine as dental tissues, but enamel and dentine arose evolutionarily together with bone as skeletal tissues in the dermal skeleton (exoskeleton) of early vertebrates. Scales and teeth of sharks are examples of dermal skeletal elements that are still composed of the three ancient components-enamel, dentine, and bone. Cartilage, on the other hand, provided the basis for the second vertebrate skeletal system, the endoskeleton (Smith and Hall, 1990; Hall, 1998a,b). some invertebrate skeletal tissues have surprisingly bone-like features. Examples include chondrocytes interconnected by cell processes in cephalopod cartilages (Cole and Hall, 2004a,b), and the calcium phosphate layer in the shells of brachiopods (Rodland et al., 2003). However, neither bone nor mineralized cartilage have been found in invertebrates. Editors notes: TODO - develops_from
skeletal tissue
-
+
@@ -37820,7 +37955,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
2012-08-14
VSAO:0000015
VSAO
@@ -37859,7 +37994,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
Organ consisting of skeletal tissue. Encompasses whole bones, fused bones, cartilaginious elements, teeth, dermal denticles.
Organ entity that is typically involved in mechanical support and may have different skeletal tissue compositions at different stages.[VSAO]
Organ entity that may have different tissue compositions at different stages and is typically involved in mechanical support.[TAO]
@@ -37875,14 +38010,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
skeletal element
-
+
-
+
VSAO
@@ -37927,7 +38062,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
@@ -37966,14 +38101,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
UBERON:0004770
articular system
-
+
-
+
FMA
@@ -38357,7 +38492,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -38441,7 +38575,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
Mesenchyme that is part of a developing trunk.
EFO:0003485
EHDAA2:0002092
@@ -38457,14 +38591,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
trunk mesenchyme
-
+
-
+
EHDAA2
@@ -38761,7 +38895,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
A delimited region of dense mesenchyme within looser mesenchyme.
AEO:0000148
EHDAA2_RETIRED:0003148
@@ -38771,7 +38905,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
UBERON:0005856
developing mesenchymal condensation
-
+
@@ -38790,7 +38924,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
AEO-modified-relation
@@ -38811,7 +38945,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -38896,7 +39029,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
The notochordal plate is the dorsal part of the notochordal process when the ventral portion breaks down. It is continuous laterally with the endoderm that composes the roof of the primitive foregut and is in contact dorsally with the neural tube. The folding off of the notochordal plate gives rise to the notochord.
TODO - check ordering; awaiting confirmation from JB
The notochordal plate is the dorsal part of the notochordal process when the ventral portion breaks down. It is continuous laterally with the endoderm that composes the roof of the primitive foregut and is in contact dorsally with the neural tube. The folding off of the notochordal plate gives rise to the notochord. [Carson_JL, Dehart_DB, Developmental_Dynamics_(1994)_201:_260-278, Gesteland_K_and_Schoenwolf_GC, Inagaki_T, Morphogenesis_of_the_murine_node_and_notochordal_plate, The_prechordal_plate, Vrablic_T, see_Mueller_F_and_O'Rahilly_R, the_rostral_end_of_the_notochord_and_nearby_median_features_in_staged_human_embryos._Cells_Tissues_Organs_(2003)_173:_1-20_and_Sulik_K][VHOG]
@@ -38911,7 +39044,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
notochordal plate
-
+
@@ -38924,7 +39057,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
EHDAA2
@@ -38954,7 +39087,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -38962,7 +39094,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
A midline cellular cord formed from the migration of mesenchymal cells from the primitive knot.
EHDAA2:0001279
EHDAA:224
@@ -38979,14 +39111,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
The notochordal process grows cranially until it reaches the prechordal plate, the future site of the mouth. In this area the ectoderm is attached directly to the endoderm without intervening mesoderm. This area is known as the oropharyngeal membrane, and it will break down to become the mouth. At the other end of the primitive streak the ectoderm is also fused directly to the endoderm; this is known as the cloacal membrane (proctodeum), or primordial anus.
notochordal process
-
+
-
+
EHDAA2
@@ -39114,7 +39246,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -39445,7 +39576,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
A hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood or analogs[GO,modified].
note we reserve the subclass 'heart' from the vertebrate multi-chambered heart. 'The first heart-like organ is believed to have appeared 500my ago in an ancestral bilaterian'. Amniotes: four-chambered heart. Amphibians: two atria, one ventricle, pulmonary; fish: single atrium and ventricle; amphioxus: tubular, non-striated, closed, unidirectional; ascidians: tubular, striated, open, bidirectional; arthropods: tubular, open; C elegans: contractile pharynx; Cnideria: striated muscle cells associated with gastrodermis
SPD:0000130
@@ -39460,14 +39591,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
Gene notes: Bmp, Nkx, Gata
primary circulatory organ
-
+
-
+
GO uses blood circulation generically to include the haemolymphatic fluid of arthropods
@@ -39557,7 +39688,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
@@ -39574,14 +39705,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
presumptive segmental plate
-
+
-
+
https://github.com/obophenotype/uberon/wiki/The-neural-crest
EDHAA2
@@ -39680,7 +39811,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
@@ -39706,7 +39837,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
presumptive paraxial mesoderm
-
+
@@ -39722,7 +39853,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
https://github.com/obophenotype/uberon/issues/1277
@@ -39770,9 +39901,8 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
-
+
Mesenchyme with little extracellular matrix.
AEO:0000146
EHDAA2:0003146
@@ -39780,7 +39910,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
UBERON:0007524
dense mesenchyme tissue
-
+
@@ -39793,7 +39923,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
AEO
@@ -39939,7 +40069,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -40097,7 +40226,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -40105,7 +40233,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
@@ -40122,14 +40250,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
UBERON:0009142
entire embryonic mesenchyme
-
+
-
+
EHDAA2
@@ -40151,7 +40279,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
EHDAA2:0002094
trunk and cervical paraxial mesenchyme
uberon
@@ -40159,14 +40287,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
UBERON:0009618
trunk paraxial mesoderm
-
+
-
+
EHDAA2
@@ -40269,7 +40397,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -40327,8 +40454,8 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
-
+
+
Anatomical cluster consisting of the skeletal elements (i.e. bone elements, cartilage elements, cartilage condensations) that are part of an individual subdivision of the organism. Excludes joints.
Anatomical cluster consisting of the skeletal elements that are part of the skeleton.[VSAO]
FMA:23879
@@ -40341,11 +40468,11 @@ MH: sexual subtypes should probably be logically defined based on sexual process
subdivision of skeleton
-
+
-
+
@@ -40358,13 +40485,13 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
UBERONREF:0000003
-
+
VSAO
@@ -40402,7 +40529,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -40736,7 +40862,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
@@ -40761,7 +40887,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
UBERON:0011899
epimysium
-
+
@@ -40774,7 +40900,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
FMA
@@ -40880,7 +41006,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
@@ -40902,7 +41028,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
UBERON:0012429
hematopoietic tissue
-
+
@@ -40915,7 +41041,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
defitional
@@ -41483,7 +41609,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
@@ -41506,7 +41632,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
UBERON:0016887
entire extraembryonic component
-
+
@@ -41519,7 +41645,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
AEO
@@ -41604,9 +41730,8 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
-
+
@@ -41622,14 +41747,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
skeletal musculature
-
+
-
+
MA
@@ -41809,7 +41934,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -41918,6 +42042,196 @@ MH: sexual subtypes should probably be logically defined based on sexual process
+
+
+
+
+
+
+
+
+ example to be eventually removed
+ example to be eventually removed
+
+
+
+
+
+
+
+ failed exploratory term
+ The term was used in an attempt to structure part of the ontology but in retrospect failed to do a good job
+ Person:Alan Ruttenberg
+ failed exploratory term
+
+
+
+
+
+
+
+ metadata complete
+ Class has all its metadata, but is either not guaranteed to be in its final location in the asserted IS_A hierarchy or refers to another class that is not complete.
+ metadata complete
+
+
+
+
+
+
+
+ organizational term
+ Term created to ease viewing/sort terms for development purpose, and will not be included in a release
+ organizational term
+
+
+
+
+
+
+
+ ready for release
+ Class has undergone final review, is ready for use, and will be included in the next release. Any class lacking "ready_for_release" should be considered likely to change place in hierarchy, have its definition refined, or be obsoleted in the next release. Those classes deemed "ready_for_release" will also derived from a chain of ancestor classes that are also "ready_for_release."
+ ready for release
+
+
+
+
+
+
+
+ metadata incomplete
+ Class is being worked on; however, the metadata (including definition) are not complete or sufficiently clear to the branch editors.
+ metadata incomplete
+
+
+
+
+
+
+
+ uncurated
+ Nothing done yet beyond assigning a unique class ID and proposing a preferred term.
+ uncurated
+
+
+
+
+
+
+
+ pending final vetting
+ All definitions, placement in the asserted IS_A hierarchy and required minimal metadata are complete. The class is awaiting a final review by someone other than the term editor.
+ pending final vetting
+
+
+
+
+
+
+
+ placeholder removed
+ placeholder removed
+
+
+
+
+
+
+
+ terms merged
+ An editor note should explain what were the merged terms and the reason for the merge.
+ terms merged
+
+
+
+
+
+
+
+ term imported
+ This is to be used when the original term has been replaced by a term imported from an other ontology. An editor note should indicate what is the URI of the new term to use.
+ term imported
+
+
+
+
+
+
+
+ term split
+ This is to be used when a term has been split in two or more new terms. An editor note should indicate the reason for the split and indicate the URIs of the new terms created.
+ term split
+
+
+
+
+
+
+
+ universal
+ Hard to give a definition for. Intuitively a "natural kind" rather than a collection of any old things, which a class is able to be, formally. At the meta level, universals are defined as positives, are disjoint with their siblings, have single asserted parents.
+ Alan Ruttenberg
+ A Formal Theory of Substances, Qualities, and Universals, http://ontology.buffalo.edu/bfo/SQU.pdf
+ universal
+
+
+
+
+
+
+
+ defined class
+ A defined class is a class that is defined by a set of logically necessary and sufficient conditions but is not a universal
+ "definitions", in some readings, always are given by necessary and sufficient conditions. So one must be careful (and this is difficult sometimes) to distinguish between defined classes and universal.
+ Alan Ruttenberg
+ defined class
+
+
+
+
+
+
+
+ named class expression
+ A named class expression is a logical expression that is given a name. The name can be used in place of the expression.
+ named class expressions are used in order to have more concise logical definition but their extensions may not be interesting classes on their own. In languages such as OWL, with no provisions for macros, these show up as actuall classes. Tools may with to not show them as such, and to replace uses of the macros with their expansions
+ Alan Ruttenberg
+ named class expression
+
+
+
+
+
+
+
+ to be replaced with external ontology term
+ Terms with this status should eventually replaced with a term from another ontology.
+ Alan Ruttenberg
+ group:OBI
+ to be replaced with external ontology term
+
+
+
+
+
+
+
+ requires discussion
+ A term that is metadata complete, has been reviewed, and problems have been identified that require discussion before release. Such a term requires editor note(s) to identify the outstanding issues.
+ Alan Ruttenberg
+ group:OBI
+ requires discussion
+
+
+
+
+
+
+
+
+
@@ -68,7 +75,34 @@
+ definition
+
+ The official definition, explaining the meaning of a class or property. Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions.
+ 2012-04-05:
+Barry Smith
+
+The official OBI definition, explaining the meaning of a class or property: 'Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions' is terrible.
+
+Can you fix to something like:
+
+A statement of necessary and sufficient conditions explaining the meaning of an expression referring to a class or property.
+
+Alan Ruttenberg
+
+Your proposed definition is a reasonable candidate, except that it is very common that necessary and sufficient conditions are not given. Mostly they are necessary, occasionally they are necessary and sufficient or just sufficient. Often they use terms that are not themselves defined and so they effectively can't be evaluated by those criteria.
+
+On the specifics of the proposed definition:
+
+We don't have definitions of 'meaning' or 'expression' or 'property'. For 'reference' in the intended sense I think we use the term 'denotation'. For 'expression', I think we you mean symbol, or identifier. For 'meaning' it differs for class and property. For class we want documentation that let's the intended reader determine whether an entity is instance of the class, or not. For property we want documentation that let's the intended reader determine, given a pair of potential relata, whether the assertion that the relation holds is true. The 'intended reader' part suggests that we also specify who, we expect, would be able to understand the definition, and also generalizes over human and computer reader to include textual and logical definition.
+
+Personally, I am more comfortable weakening definition to documentation, with instructions as to what is desirable.
+
+We also have the outstanding issue of how to aim different definitions to different audiences. A clinical audience reading chebi wants a different sort of definition documentation/definition from a chemistry trained audience, and similarly there is a need for a definition that is adequate for an ontologist to work with.
+ PERSON:Daniel Schober
+ GROUP:OBI:<http://purl.obolibrary.org/obo/obi>
+
definition
+ definition
@@ -76,12 +110,19 @@
+ editor note
+
+ An administrative note intended for its editor. It may not be included in the publication version of the ontology, so it should contain nothing necessary for end users to understand the ontology.
+ PERSON:Daniel Schober
+ GROUP:OBI:<http://purl.obofoundry.org/obo/obi>
IAO:0000116
uberon
editor_note
true
editor_note
+
editor note
+ editor note
@@ -106,7 +147,13 @@
-
+
+ has obsolescence reason
+ Relates an annotation property to an obsolescence reason. The values of obsolescence reasons come from a list of predefined terms, instances of the class obsolescence reason specification.
+ PERSON:Alan Ruttenberg
+ PERSON:Melanie Courtot
+ has obsolescence reason
+
@@ -119,6 +166,12 @@
+ term tracker item
+ the URI for an OBI Terms ticket at sourceforge, such as https://sourceforge.net/p/obi/obi-terms/772/
+
+ An IRI or similar locator for a request or discussion of an ontology term.
+ Person: Jie Zheng, Chris Stoeckert, Alan Ruttenberg
+ Person: Jie Zheng, Chris Stoeckert, Alan Ruttenberg
IAO:0000233
external
uberon
@@ -126,7 +179,9 @@
true
true
term_tracker_item
+ The 'tracker item' can associate a tracker with a specific ontology term.
term tracker item
+ term tracker item
@@ -134,7 +189,15 @@
+ expand expression to
+ ObjectProperty: RO_0002104
+Label: has plasma membrane part
+Annotations: IAO_0000424 "http://purl.obolibrary.org/obo/BFO_0000051 some (http://purl.org/obo/owl/GO#GO_0005886 and http://purl.obolibrary.org/obo/BFO_0000051 some ?Y)"
+
+ A macro expansion tag applied to an object property (or possibly a data property) which can be used by a macro-expansion engine to generate more complex expressions from simpler ones
+ Chris Mungall
expand expression to
+ expand expression to
@@ -166,12 +229,16 @@
+ has ontology root term
+ Ontology annotation property. Relates an ontology to a term that is a designated root term of the ontology. Display tools like OLS can use terms annotated with this property as the starting point for rendering the ontology class hierarchy. There can be more than one root.
+ Nicolas Matentzoglu
IAO:0000700
uberon
has_ontology_root_term
true
has_ontology_root_term
has ontology root term
+ has ontology root term
preferred_root
@@ -186,7 +253,14 @@
+ term replaced by
+
+ Use on obsolete terms, relating the term to another term that can be used as a substitute
+ Person:Alan Ruttenberg
+ Person:Alan Ruttenberg
+ Add as annotation triples in the granting ontology
term replaced by
+ term replaced by
@@ -512,6 +586,12 @@ WHERE {
+
+
+
+
+
+
@@ -1060,6 +1140,7 @@ WHERE {
+ a mis-spelling that is in common use and thus recorded
@@ -1876,6 +1957,12 @@ WHERE {
+
+
+
+
+
+
+
+
+ This document is about information artifacts and their representations
+
+ A (currently) primitive relation that relates an information artifact to an entity.
+ 7/6/2009 Alan Ruttenberg. Following discussion with Jonathan Rees, and introduction of "mentions" relation. Weaken the is_about relationship to be primitive.
+
+We will try to build it back up by elaborating the various subproperties that are more precisely defined.
+
+Some currently missing phenomena that should be considered "about" are predications - "The only person who knows the answer is sitting beside me" , Allegory, Satire, and other literary forms that can be topical without explicitly mentioning the topic.
+ person:Alan Ruttenberg
+ Smith, Ceusters, Ruttenberg, 2000 years of philosophy
+ is about
+
+
+
+
@@ -2743,6 +2850,7 @@ range: spatial region or site (immaterial continuant)
located_in
located in
located in
+ https://wiki.geneontology.org/Located_in
@@ -2810,7 +2918,7 @@ range: spatial region or site (immaterial continuant)
-
+
@@ -2873,7 +2981,7 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
A 'has regulatory component activity' B if A and B are GO molecular functions (GO_0003674), A has_component B and A is regulated by B.
- dos
+
2017-05-24T09:30:46Z
RO:0002013
external
@@ -2890,7 +2998,7 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
A relationship that holds between a GO molecular function and a component of that molecular function that negatively regulates the activity of the whole. More formally, A 'has regulatory component activity' B iff :A and B are GO molecular functions (GO_0003674), A has_component B and A is negatively regulated by B.
- dos
+
2017-05-24T09:31:01Z
RO:0002014
external
@@ -2908,7 +3016,7 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
A relationship that holds between a GO molecular function and a component of that molecular function that positively regulates the activity of the whole. More formally, A 'has regulatory component activity' B iff :A and B are GO molecular functions (GO_0003674), A has_component B and A is positively regulated by B.
- dos
+
2017-05-24T09:31:17Z
By convention GO molecular functions are classified by their effector function and internal regulatory functions are treated as components. So, for example calmodulin has a protein binding activity that has positive regulatory component activity calcium binding activity. Receptor tyrosine kinase activity is a tyrosine kinase activity that has positive regulatory component 'ligand binding'.
has positive regulatory component activity
@@ -2920,7 +3028,7 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
- dos
+
2017-05-24T09:44:33Z
A 'has component activity' B if A is A and B are molecular functions (GO_0003674) and A has_component B.
has component activity
@@ -2935,7 +3043,7 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
w 'has process component' p if p and w are processes, w 'has part' p and w is such that it can be directly disassembled into into n parts p, p2, p3, ..., pn, where these parts are of similar type.
- dos
+
2017-05-24T09:49:21Z
has component process
@@ -2947,7 +3055,7 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
A relationship between a process and a barrier, where the process occurs in a region spanning the barrier. For cellular processes the barrier is typically a membrane. Examples include transport across a membrane and membrane depolarization.
- dos
+
2017-07-20T17:19:37Z
occurs across
@@ -2959,7 +3067,7 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
- dos
+
2017-09-17T13:52:24Z
Process(P2) is directly regulated by process(P1) iff: P1 regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding regulates the kinase activity (P2) of protein B then P1 directly regulates P2.
directly regulated by
@@ -2968,7 +3076,7 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
Process(P2) is directly regulated by process(P1) iff: P1 regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding regulates the kinase activity (P2) of protein B then P1 directly regulates P2.
- GOC:dos
+
@@ -2979,7 +3087,7 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
Process(P2) is directly negatively regulated by process(P1) iff: P1 negatively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding negatively regulates the kinase activity (P2) of protein B then P2 directly negatively regulated by P1.
- dos
+
2017-09-17T13:52:38Z
directly negatively regulated by
@@ -2987,7 +3095,7 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
Process(P2) is directly negatively regulated by process(P1) iff: P1 negatively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding negatively regulates the kinase activity (P2) of protein B then P2 directly negatively regulated by P1.
- GOC:dos
+
@@ -2998,7 +3106,7 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
Process(P2) is directly postively regulated by process(P1) iff: P1 positively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding positively regulates the kinase activity (P2) of protein B then P2 is directly postively regulated by P1.
- dos
+
2017-09-17T13:52:47Z
directly positively regulated by
@@ -3006,7 +3114,7 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
Process(P2) is directly postively regulated by process(P1) iff: P1 positively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding positively regulates the kinase activity (P2) of protein B then P2 is directly postively regulated by P1.
- GOC:dos
+
@@ -3017,7 +3125,7 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
A 'has effector activity' B if A and B are GO molecular functions (GO_0003674), A 'has component activity' B and B is the effector (output function) of B. Each compound function has only one effector activity.
- dos
+
2017-09-22T14:14:36Z
This relation is designed for constructing compound molecular functions, typically in combination with one or more regulatory component activity relations.
has effector activity
@@ -3026,7 +3134,7 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
A 'has effector activity' B if A and B are GO molecular functions (GO_0003674), A 'has component activity' B and B is the effector (output function) of B. Each compound function has only one effector activity.
- GOC:dos
+
@@ -3048,7 +3156,9 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
+
+ x simultaneous with y iff ω(x) = ω(y) and ω(α ) = ω(α), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point and '=' indicates the same instance in time.
David Osumi-Sutherland
RO:0002082
@@ -3129,14 +3239,14 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
-
+
+ Relation between a neuron and a material anatomical entity that its soma is part of.
Relation between a neuron and an anatomical structure that its soma is part of.
- Relation between a neuron and an anatomical structure that its soma is part of.
<http://purl.obolibrary.org/obo/BFO_0000051> some (
<http://purl.obolibrary.org/obo/GO_0043025> and <http://purl.obolibrary.org/obo/BFO_0000050> some ?Y)
@@ -3274,8 +3384,8 @@ boundary_of: http://purl.obolibrary.org/obo/RO_0002000
-
-
+
+
Every B cell[CL_0000236] has plasma membrane part some immunoglobulin complex[GO_0019814]
Holds between a cell c and a protein complex or protein p if and only if that cell has as part a plasma_membrane[GO:0005886], and that plasma membrane has p as part.
@@ -3624,7 +3734,6 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.
-
@@ -3801,8 +3910,8 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.
-
-
+
+
@@ -3934,7 +4043,7 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.
-
+
@@ -3956,16 +4065,16 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.
-
+
-
+
@@ -4326,7 +4435,7 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.
-
+
@@ -4464,6 +4573,7 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.has_input
has input
has input
+ https://wiki.geneontology.org/Has_input
@@ -4491,6 +4601,7 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.has_output
has output
has output
+ https://wiki.geneontology.org/Has_output
@@ -4500,8 +4611,8 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.
-
-
+
+
@@ -4543,8 +4654,8 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.
-
-
+
+
t1 induced_by t2 if there is a process of developmental induction (GO:0031128) with t1 and t2 as interacting participants. t2 causes t1 to change its fate from a precursor material anatomical entity type T to T', where T' develops_from T
@@ -4626,7 +4737,7 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.affects
acts upstream of or within
-
+ https://wiki.geneontology.org/Acts_upstream_of_or_within
@@ -4683,7 +4794,7 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.
- Inverse of 'expressed in'
+ y expresses x if and only if there is a gene expression process (GO:0010467) that occurs in y, and one of the following holds: (i) x is a gene, and x is transcribed into a transcript as part of the gene expression process (ii) x is a transcript, and x was transcribed from a gene as part of the gene expression process (iii) x is a mature gene product (protein or RNA), and x was translated or otherwise processed from a transcript that was transcribed as part of the gene expression process.
expresses
@@ -4695,7 +4806,7 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.
-
+
p results in the developmental progression of s iff p is a developmental process and s is an anatomical entity and p causes s to undergo a change in state at some point along its natural developmental cycle (this cycle starts with its formation, through the mature structure, and ends with its loss).
This property and its subproperties are being used primarily for the definition of GO developmental processes. The property hierarchy mirrors the core GO hierarchy. In future we may be able to make do with a more minimal set of properties, but due to the way GO is currently structured we require highly specific relations to avoid incorrect entailments. To avoid this, the corresponding genus terms in GO should be declared mutually disjoint.
@@ -4822,6 +4933,7 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.causally_upstream_of,_positive_effect
holds between x and y if and only if x is causally upstream of y and the progression of x increases the frequency, rate or extent of y
causally upstream of, positive effect
+
@@ -4841,6 +4953,7 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.
causally_upstream_of,_negative_effect
causally upstream of, negative effect
+
@@ -4883,7 +4996,7 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.
-
+
an annotation of gene X to cell differentiation with results_in_maturation_of CL:0000057 (fibroblast) means that at the end of the process the input cell that did not have features of a fibroblast, now has the features of a fibroblast.
The relationship that links a specified entity with the process that results in an unspecified entity acquiring the features and characteristics of the specified entity
@@ -4959,6 +5072,7 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.This relation differs from the parent relation 'capable of' in that the parent is weaker and only expresses a capability that may not be actually realized, whereas this relation is always realized.
enables
+ https://wiki.geneontology.org/Enables
@@ -5035,7 +5149,7 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.actively involved in
enables part of
involved in
-
+ https://wiki.geneontology.org/Involved_in
@@ -5070,6 +5184,7 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.
enabled by
+ https://wiki.geneontology.org/Enabled_by
@@ -5374,7 +5489,7 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.
-
+
m has_muscle_origin s iff m is attached_to s, and it is the case that when m contracts, s does not move. The site of the origin tends to be more proximal and have greater mass than what the other end attaches to.
Wikipedia:Insertion_(anatomy)
@@ -5389,7 +5504,7 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.
-
+
We need to import uberon muscle to create a stricter domain constraint
@@ -5400,7 +5515,7 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.
-
+
m has_muscle_insertion s iff m is attaches_to s, and it is the case that when m contracts, s moves. Insertions are usually connections of muscle via tendon to bone.
Wikipedia:Insertion_(anatomy)
@@ -5415,7 +5530,7 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.
-
+
We need to import uberon muscle into RO to use as a stricter domain constraint
@@ -5520,8 +5635,8 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.
-
-
+
+
x has developmental potential involving y iff x is capable of a developmental process with output y. y may be the successor of x, or may be a different structure in the vicinity (as for example in the case of developmental induction).
@@ -5652,6 +5767,7 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.indirectly activates
indirectly positively regulates
+ https://wiki.geneontology.org/Indirectly_positively_regulates
@@ -5679,6 +5795,7 @@ Expands_to: T has_fasciculating_neuron_projection that synapse_in some R.indirectly inhibits
indirectly negatively regulates
+ https://wiki.geneontology.org/Indirectly_negatively_regulates
@@ -5882,6 +5999,7 @@ Each of these 3 primitives can be composed to yield a cross-product of different
enables activity in
is active in
+ https://wiki.geneontology.org/Is_active_in
@@ -5896,8 +6014,8 @@ Each of these 3 primitives can be composed to yield a cross-product of different
c executes activity in d if and only if c enables p and p occurs_in d. Assuming no action at a distance by gene products, if a gene product enables (is capable of) a process that occurs in some structure, it must have at least some part in that structure.
- GOC:cjm
- GOC:dos
+
+
@@ -6408,9 +6526,9 @@ For example, A and B may be gene products and binding of B by A positively regul
-
+
-
+
Forelimb SubClassOf has_skeleton some 'Forelimb skeleton'
A relation between a segment or subdivision of an organism and the maximal subdivision of material entities that provides structural support for that segment or subdivision.
@@ -6426,7 +6544,7 @@ For example, A and B may be gene products and binding of B by A positively regul
-
+
This should be to a more restricted class, but not the Uberon class may be too restricted since it is a composition-based definition of skeleton rather than functional.
@@ -6516,8 +6634,8 @@ For example, A and B may be gene products and binding of B by A positively regul
-
-
+
+
A relation that holds between elements of a musculoskeletal system or its analogs.
Do not use this relation directly. It is ended as a grouping for a diverse set of relations, all involving the biomechanical processes.
@@ -6588,7 +6706,7 @@ For example, A and B may be gene products and binding of B by A positively regul
x lumen_of y iff x is the space or substance that is part of y and does not cross any of the inner membranes or boundaries of y that is maximal with respect to the volume of the convex hull.
- GOC:cjm
+
RO:0002571
uberon
lumen_of
@@ -6620,8 +6738,8 @@ For example, A and B may be gene products and binding of B by A positively regul
-
-
+
+
inverse of has skeleton
RO:0002576
@@ -6806,6 +6924,16 @@ For example, A and B may be gene products and binding of B by A positively regul
+
+
+
+ A relationship that holds between two entities, where the entities exhibit a statistical dependence relationship. The entities may be statistical variables, or they may be other kinds of entities such as diseases, chemical entities or processes.
+ Groups both positive and negative correlation
+ correlated with
+
+
+
+
@@ -6823,6 +6951,7 @@ For example, A and B may be gene products and binding of B by A positively regul
directly_positively_regulates
directly positively regulates
+ https://wiki.geneontology.org/Directly_positively_regulates
@@ -6844,6 +6973,7 @@ For example, A and B may be gene products and binding of B by A positively regul
directly_negatively_regulates
directly negatively regulates
+ https://wiki.geneontology.org/Directly_negatively_regulates
@@ -6932,7 +7062,7 @@ For example, A and B may be gene products and binding of B by A positively regul
p has primary output c if (a) p has output c and (b) the goal of process is to modify, produce, or transform c.
- GOC:cjm
+
GOC:dph
GOC:kva
GOC:pt
@@ -6960,7 +7090,7 @@ For example, A and B may be gene products and binding of B by A positively regul
p has primary input c if (a) p has input c and (b) the goal of process is to modify, consume, or transform c.
- GOC:cjm
+
GOC:dph
GOC:kva
GOC:pt
@@ -6998,7 +7128,7 @@ For example, A and B may be gene products and binding of B by A positively regul
2018-01-26T23:49:30Z
acts upstream of or within, positive effect
-
+ https://wiki.geneontology.org/Acts_upstream_of_or_within,_positive_effect
@@ -7016,6 +7146,7 @@ For example, A and B may be gene products and binding of B by A positively regul
2018-01-26T23:49:51Z
acts upstream of or within, negative effect
+ https://wiki.geneontology.org/Acts_upstream_of_or_within,_negative_effect
@@ -7035,7 +7166,7 @@ For example, A and B may be gene products and binding of B by A positively regul
2018-01-26T23:53:14Z
acts upstream of, positive effect
-
+ https://wiki.geneontology.org/Acts_upstream_of,_positive_effect
@@ -7055,7 +7186,7 @@ For example, A and B may be gene products and binding of B by A positively regul
2018-01-26T23:53:22Z
acts upstream of, negative effect
-
+ https://wiki.geneontology.org/Acts_upstream_of,_negative_effect
@@ -7068,6 +7199,7 @@ For example, A and B may be gene products and binding of B by A positively regul
2018-03-13T23:55:05Z
causally upstream of or within, negative effect
+ https://wiki.geneontology.org/Causally_upstream_of_or_within,_negative_effect
@@ -7080,6 +7212,7 @@ For example, A and B may be gene products and binding of B by A positively regul
2018-03-13T23:55:19Z
causally upstream of or within, positive effect
+
@@ -7102,7 +7235,7 @@ For example, A and B may be gene products and binding of B by A positively regul
p acts on population of c iff c' is a collection, has members of type c, and p has participant c
- pg
+
2020-06-08T17:21:33Z
RO:0012003
external
@@ -7121,7 +7254,7 @@ For example, A and B may be gene products and binding of B by A positively regul
- pg
+
2021-02-26T07:28:29Z
RO:0012008
external
@@ -7141,7 +7274,7 @@ For example, A and B may be gene products and binding of B by A positively regul
p is indirectly causally upstream of q iff p is causally upstream of q and there exists some process r such that p is causally upstream of r and r is causally upstream of q.
- pg
+
2022-09-26T06:07:17Z
indirectly causally upstream of
@@ -7154,7 +7287,7 @@ For example, A and B may be gene products and binding of B by A positively regul
p indirectly regulates q iff p is indirectly causally upstream of q and p regulates q.
- pg
+
2022-09-26T06:08:01Z
indirectly regulates
@@ -7170,7 +7303,7 @@ For example, A and B may be gene products and binding of B by A positively regul
A relationship between a neuron and a region, where the neuron has a functionally relevant number of input and/or output synapses in that region.
-
+
2020-07-17T09:26:52Z
has synaptic input or output in
has synaptic IO in region
@@ -7187,7 +7320,7 @@ For example, A and B may be gene products and binding of B by A positively regul
Relation between a sensory neuron and some structure in which it receives sensory input via a sensory dendrite.
-
+
2020-07-20T12:10:09Z
has sensory dendrite location
has sensory terminal in
@@ -7283,8 +7416,8 @@ For example, A and B may be gene products and binding of B by A positively regul
'Ly-76 high positive erythrocyte' equivalent to 'enucleate erythrocyte' and (has_high_plasma_membrane_amount some 'lymphocyte antigen 76 (mouse)')
A relation between a cell and molecule or complex such that every instance of the cell has a high number of instances of that molecule expressed on the cell surface.
-
-
+
+
has high plasma membrane amount
@@ -7303,8 +7436,8 @@ For example, A and B may be gene products and binding of B by A positively regul
'DN2b thymocyte' equivalent to 'DN2 thymocyte' and (has_low_plasma_membrane_amount some 'mast/stem cell growth factor receptor')
A relation between a cell and molecule or complex such that every instance of the cell has a low number of instances of that molecule expressed on the cell surface.
-
-
+
+
has low plasma membrane amount
@@ -7336,6 +7469,20 @@ For example, A and B may be gene products and binding of B by A positively regul
+
+
+
+
+
+
+ A relation between entities in which one increases or decreases as the other does the same.
+ directly correlated with
+
+ positively correlated with
+
+
+
+
@@ -7807,7 +7954,8 @@ For example, A and B may be gene products and binding of B by A positively regul
- A continuant that is a bearer of quality and realizable entity entities, in which other entities inhere and which itself cannot inhere in anything.
+ b is an independent continuant = Def. b is a continuant which is such that there is no c and no t such that b s-depends_on c at t. (axiom label in BFO2 Reference: [017-002])
+ A continuant that is a bearer of quality and realizable entity entities, in which other entities inhere and which itself cannot inhere in anything.
independent continuant
@@ -7817,7 +7965,8 @@ For example, A and B may be gene products and binding of B by A positively regul
- An occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t.
+ p is a process = Def. p is an occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t. (axiom label in BFO2 Reference: [083-003])
+ An occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t.
process
@@ -7833,7 +7982,8 @@ For example, A and B may be gene products and binding of B by A positively regul
- A continuant that inheres in or is borne by other entities. Every instance of A requires some specific instance of B which must always be the same.
+ b is a specifically dependent continuant = Def. b is a continuant & there is some independent continuant c which is not a spatial region and which is such that b s-depends_on c at every time t during the course of b’s existence. (axiom label in BFO2 Reference: [050-003])
+ A continuant that inheres in or is borne by other entities. Every instance of A requires some specific instance of B which must always be the same.
specifically dependent continuant
@@ -8492,7 +8642,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -8868,7 +9017,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -9176,7 +9324,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -9316,7 +9463,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -9456,7 +9602,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -9816,7 +9961,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -10986,7 +11130,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -11167,7 +11310,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -11258,7 +11400,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -11741,7 +11882,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -11922,7 +12062,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -12056,7 +12195,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -12124,7 +12262,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -12379,7 +12516,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -12467,7 +12603,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -12593,7 +12728,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -13360,7 +13494,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -13458,7 +13591,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -13505,7 +13637,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -14101,7 +14232,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -14354,7 +14484,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -14636,7 +14765,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -15049,7 +15177,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -15386,7 +15513,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -15565,7 +15691,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -15656,7 +15781,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -15701,7 +15825,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -15747,7 +15870,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -15786,7 +15908,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -16375,7 +16496,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -16488,7 +16608,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -16600,7 +16719,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -34616,6 +34734,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PR:000001006
Category=gene. Requested by=CL.
receptor-type tyrosine-protein phosphatase C
+
@@ -34665,6 +34784,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PR:000001012
Category=gene. Requested by=CL.
integrin alpha-M
+
@@ -34711,6 +34831,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PR:000001013
Category=gene. Requested by=CL.
integrin alpha-X
+
@@ -34848,6 +34969,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PR:000001024
Category=gene. Requested by=CL.
neural cell adhesion molecule 1
+
@@ -34932,6 +35054,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PR:000001084
Category=gene. Requested by=CL.
T-cell surface glycoprotein CD8 alpha chain
+
@@ -35082,6 +35205,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PR:000001254
Category=gene. Requested by=CL.
C-C chemokine receptor type 1
+
@@ -35139,6 +35263,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PR:000001255
Category=gene. Requested by=CL.
C-C chemokine receptor type 3
+
@@ -35352,6 +35477,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PR:000001332
Category=gene. Requested by=CL.
carcinoembryonic antigen-related cell adhesion molecule 8
+
@@ -35438,6 +35564,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PR:000001344
Category=gene. Requested by=CL.
ectonucleotide pyrophosphatase/phosphodiesterase family member 3
+
@@ -35523,6 +35650,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PR:000001408
Category=gene. Requested by=CL.
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
+
@@ -35554,6 +35682,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PR:000001444
Category=gene. Requested by=CL.
cadherin-5
+
@@ -35675,6 +35804,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PR:000001839
Category=gene. Requested by=CL.
T-cell surface glycoprotein CD5
+
@@ -35714,6 +35844,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PR:000001850
Category=gene. Requested by=CL.
cathepsin K
+
@@ -35831,6 +35962,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PR:000001867
Category=gene. Requested by=CL.
interleukin-5 receptor subunit alpha
+
@@ -35872,6 +36004,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PR:000001869
Category=gene. Requested by=CL.
interleukin-7 receptor subunit alpha
+
@@ -35928,6 +36061,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PR:000001879
Category=gene. Requested by=CL.
leukosialin
+
@@ -36004,6 +36138,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PR:000001898
Category=gene. Requested by=CL.
neprilysin
+
@@ -36040,6 +36175,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PR:000001903
Category=gene. Requested by=CL.
paired box protein PAX-5
+
@@ -36082,6 +36218,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PR:000001932
Category=gene. The mouse ortholog is Cd24a. Mouse protein Cd24b likely also orthologous. Currently it is not in UniProt. Requested by=CL.
signal transducer CD24
+
@@ -36120,6 +36257,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PR:000001935
Category=gene. Requested by=CL.
syndecan-1
+
@@ -36166,6 +36304,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PR:000001937
Category=gene. Requested by=CL.
tartrate-resistant acid phosphatase type 5
+
@@ -36209,6 +36348,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PR:000001944
Category=gene. Requested by=CL.
transcription factor PU.1
+
@@ -36255,6 +36395,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PR:000001945
Category=gene. Requested by=CL.
transferrin receptor protein 1
+
@@ -36355,6 +36496,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PR:000001954
Category=gene. Requested by=CL.
tumor necrosis factor receptor superfamily member 11A
+
@@ -36435,6 +36577,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PR:000001969
Category=gene. Requested by=CL.
urokinase plasminogen activator surface receptor
+
@@ -36504,6 +36647,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PR:000002062
Category=gene. Requested by=CL.
macrophage colony-stimulating factor 1 receptor
+
@@ -36599,6 +36743,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PR:000002112
Category=gene. Requested by=CL.
vascular endothelial growth factor receptor 2
+
@@ -36794,6 +36939,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PR:000003457
Category=gene. Requested by=CL.
V(D)J recombination-activating protein 1
+
@@ -36828,6 +36974,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PR:000003460
Category=gene. Requested by=CL.
V(D)J recombination-activating protein 2
+
@@ -36920,6 +37067,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PR:000005307
Category=gene. Requested by=CL.
CCAAT/enhancer-binding protein alpha
+
@@ -36989,6 +37137,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PR:000006611
Category=gene. Requested by=CL.
DNA nucleotidylexotransferase
+
@@ -37027,6 +37176,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PR:000007431
Category=gene. Requested by=CL.
high affinity immunoglobulin epsilon receptor subunit alpha
+
@@ -37065,6 +37215,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PR:000007597
Category=gene. Requested by=CL.
protein c-Fos
+
@@ -37105,6 +37256,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PR:000007857
Category=gene. Requested by=CL.
erythroid transcription factor
+
@@ -37145,6 +37297,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PR:000007858
Category=gene. Requested by=CL.
endothelial transcription factor GATA-2
+
@@ -37176,6 +37329,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PR:000009143
Category=gene. Requested by=CL.
integrin beta-7
+
@@ -37210,6 +37364,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PR:000011178
Category=gene. Requested by=CL.
nuclear factor NF-kappa-B p100 subunit
+
@@ -37247,6 +37402,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PR:000014841
Category=gene.
sonic hedgehog protein
+
@@ -37288,6 +37444,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PR:000016043
Category=gene. Requested by=CL.
T-cell acute lymphocytic leukemia protein 1
+
@@ -37339,6 +37496,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
PR:000016401
Category=gene. Requested by=CL.
transmembrane emp24 domain-containing protein 1
+
@@ -38772,6 +38930,8 @@ MH: sexual subtypes should probably be logically defined based on sexual process
Staged defined by the formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system.
+
+ In zebrafish, the times of neurulation and segmentation overlap so extensively there is no distinct neurula period of development, such as occurs largely before segmentation in amphibian embryos.
BILS:0000110
BilaDO:0000009
HsapDv:0000012
@@ -38780,6 +38940,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
uberon
UBERON:0000110
neurula stage
+ https://github.com/obophenotype/developmental-stage-ontologies/issues/84
https://github.com/obophenotype/uberon/issues/343
@@ -38802,12 +38963,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
-
-
-
-
-
@@ -38832,6 +38987,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
segmentation stage
UBERON:0000111
organogenesis stage
+ https://github.com/obophenotype/developmental-stage-ontologies/issues/84
https://github.com/obophenotype/uberon/issues/533
@@ -38904,7 +39060,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -38918,7 +39073,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
@@ -38991,7 +39146,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
https://github.com/obophenotype/uberon/issues/661
http://upload.wikimedia.org/wikipedia/commons/0/06/Mouth_illustration-Otis_Archives.jpg
-
+
@@ -39004,7 +39159,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
exceptions in some taxa
@@ -39121,7 +39276,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -39130,15 +39284,15 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
-
-
+
+
A fluid that is composed of blood plasma and erythrocytes.
This class excludes blood analogues, such as the insect analog of blood. See UBERON:0000179 haemolymphatic fluid.
@@ -39180,34 +39334,34 @@ MH: sexual subtypes should probably be logically defined based on sexual process
blood
-
+
-
+
-
+
-
+
CL:tm
-
+
https://github.com/obophenotype/uberon/issues/1330
-
+
Bgee:AN
@@ -39330,7 +39484,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -39396,7 +39549,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -39513,7 +39665,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
@@ -39555,14 +39707,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
organism substance
-
+
-
+
this relationship may be too strong and may be weakened in future
@@ -40526,7 +40678,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -40793,7 +40944,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
Primary germ layer that is the outer of the embryo's three germ layers and gives rise to epidermis and neural tissue.
Primary germ layer that is the outer of the embryonic germ layers and gives rise to epidermis and neural tissue.[AAO]
The Bilateria are triploblastic (with true endoderm, mesoderm, and ectoderm) (...).[well established][VHOG]
@@ -40831,14 +40982,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
ectoderm
http://upload.wikimedia.org/wikipedia/commons/1/19/Gray32.png
-
+
-
+
Bgee:AN
@@ -40891,7 +41042,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
Primary germ layer that lies remote from the surface of the embryo and gives rise to internal tissues such as gut.
The Bilateria are triploblastic (with true endoderm, mesoderm, and ectoderm) (...).[well established][VHOG]
endodermal
@@ -40928,14 +41079,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
http://upload.wikimedia.org/wikipedia/commons/c/c0/Endoderm2.png
http://upload.wikimedia.org/wikipedia/commons/d/df/Gray10.png
-
+
-
+
Bgee:AN
@@ -40980,7 +41131,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
The middle germ layer of the embryo, between the endoderm and ectoderm.
Primary germ layer that is the middle of the embryonic germ layers.[AAO]
@@ -41025,7 +41176,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
mesoderm
http://upload.wikimedia.org/wikipedia/commons/e/e8/Mesoderm.png
-
+
@@ -41038,7 +41189,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
Bgee:AN
@@ -41245,7 +41396,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
@@ -41319,14 +41470,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
Taxon notes:" the ascidian tube-like heart lacks chambers....The ascidian heart is formed after metamorphosis as a simple tube-like structure with a single-layered myoepithelium that is continuous with a single-layered pericar- dial wall. It lacks chambers and endocardium.... The innovation of the chambered heart was a key event in vertebrate evolution, because the chambered heart generates one-way blood flow with high pressure, a critical requirement for the efficient blood supply of large-body vertebrates... all extant vertebrates have hearts with two or more chambers (Moorman and Christoffels 2003)" DOI:10.1101/gad.1485706
heart
-
+
-
+
MA
@@ -41858,7 +42009,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -41952,7 +42102,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -41984,7 +42133,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
@@ -42037,14 +42186,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
http://upload.wikimedia.org/wikipedia/commons/b/b2/TE-Nervous_system_diagram.svg
http://upload.wikimedia.org/wikipedia/commons/b/ba/Nervous_system_diagram.png
-
+
-
+
Bgee:AN
@@ -42132,7 +42281,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the neural tube derivatives: the brain and spinal cord. In invertebrates it includes central ganglia plus nerve cord.
Part of the nervous system which includes the brain and spinal cord.[AAO]
@@ -42179,7 +42328,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
central nervous system
-
+
@@ -42193,7 +42342,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
Bgee:AN
@@ -42687,7 +42836,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
Skeletal element that is composed of bone tissue.
@@ -42737,14 +42886,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
bone element
-
+
-
+
VSAO-modified
@@ -42836,7 +42985,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -42856,7 +43004,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
A tube extending from the mouth to the anus.
@@ -42896,14 +43044,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
digestive tract
-
+
-
+
NCBIBook:NBK10107
@@ -43172,7 +43320,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -43181,8 +43328,8 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
-
+
+
@@ -43195,7 +43342,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
@@ -43254,34 +43401,34 @@ MH: sexual subtypes should probably be logically defined based on sexual process
blood vessel
http://upload.wikimedia.org/wikipedia/commons/2/29/Circulatory_System_en.svg
-
+
-
+
-
+
-
+
AEO
-
+
EHDAA2
-
+
GO:0072360
@@ -43731,7 +43878,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -43986,7 +44132,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -44006,7 +44151,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
@@ -44040,14 +44185,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
musculoskeletal system
-
+
-
+
check ctenophore
@@ -44175,9 +44320,8 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
-
+
@@ -44218,14 +44362,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
coelemic cavity lumen
-
+
-
+
definitional
@@ -44333,9 +44477,9 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
-
-
+
+
+
@@ -44390,15 +44534,15 @@ MH: sexual subtypes should probably be logically defined based on sexual process
notochord
http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png
-
+
-
+
-
+
@@ -44417,19 +44561,19 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
http://tolweb.org/Chordata/2499
-
+
ZFA
-
+
EHDAA2
@@ -44512,11 +44656,10 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
-
-
+
+
Somites are spheres of epithelial cells that form sequentially along the anterior-posterior axis of the embryo through mesenchymal to epithelial transition of the presomitic mesoderm.
currently classified as an epithelial vesicle, consistent with EHDAA2 and https://github.com/obophenotype/uberon/wiki/The-neural-crest. Consider making 'somitic mesoderm' a separate term and correlate with regionalization processes. Consider moving ZFA term to 'trunk somite' as it is part of the trunk
@@ -44562,11 +44705,11 @@ MH: sexual subtypes should probably be logically defined based on sexual process
somite
http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png
-
+
-
+
@@ -44579,13 +44722,13 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
GOTAX:0000352
-
+
ZFA
@@ -44698,12 +44841,12 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
-
-
-
-
-
+
+
+
+
+
+
A specialized region of ectoderm found between the neural ectoderm (neural plate) and non-neural ectoderm and composed of highly migratory pluripotent cells that delaminate in early embryonic development from the dorsal neural tube and give rise to an astounding variety of differentiated cell types[MP].
consider including subclasses for pre- and post- migratory (e.g. sheets/paths/streams).
@@ -44743,66 +44886,66 @@ MH: sexual subtypes should probably be logically defined based on sexual process
http://upload.wikimedia.org/wikipedia/commons/5/5f/Gray644.png
https://upload.wikimedia.org/wikipedia/commons/8/8f/Neural_Crest.png
-
+
-
+
-
+
-
+
-
+
-
+
-
+
XAO
https://github.com/obophenotype/uberon/wiki/The-neural-crest
-
+
Hall and others restrict NC to vertebrates but we opt for a less restrictive constraint to avoid inconsistencies when areas such as P1 area of pallium in hagfishes inherit cell lineage from telecephalon-contributing NC cells
ISBN:0073040584
-
+
BTO
-
+
PMID:11523831
-
+
pre migratory https://github.com/obophenotype/uberon/wiki/The-neural-crest
-
+
PMID:11523831
@@ -44990,7 +45133,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
@@ -45048,14 +45191,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
bone marrow
http://upload.wikimedia.org/wikipedia/commons/7/74/Gray72-en.svg
-
+
-
+
FMA
MA
@@ -45324,17 +45467,16 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
-
+
-
+
Anatomical system that is involved in the production of hematopoietic cells.
Anatomical system that consists of the blood and blood forming tissues.[AAO]
@@ -45377,24 +45519,24 @@ MH: sexual subtypes should probably be logically defined based on sexual process
hematopoietic system
-
+
-
+
-
+
FMA
-
+
definitional
@@ -45765,7 +45907,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
Unsegmented field of paraxial mesoderm present posterior to the most recently formed somite pair, from which somites will form.
Unsegmented field of paraxial mesoderm present posterior to the most recently formed somite pair, from which somites will form. Kimmel et al, 1995.[TAO]
It is reasonable to assume that the proximate invertebrate ancestor of the vertebrates had an amphioxus-like tail bud in its larval stage. This archetypal tail bud would have (...) (3) lacked any component of mesenchyme cells, (4) budded off new mesodermal segments directly, without any intervening zone of presomitic mesoderm (...). Then, early in vertebrate evolution, epithelium-to-mesenchyme interconversions (and the gene networks for effecting them) became prominent features of development. (...) In any case, conspicuous mesenchymal components tended to be added to the vertebrate tail bud itself. In addition, a mesenchymatous presomitic mesoderm (not a part of the tail bud proper) came to intervene between the tail bud and the forming somites.[well established][VHOG]
@@ -45790,14 +45932,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process
presomitic mesoderm
-
+
-
+
Bgee:AN
@@ -45960,7 +46102,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
@@ -46025,13 +46166,12 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
-
-
-
+
+
+
A region of embryonic ectodermal cells that lie directly above the notochord. During neurulation, they change shape and produce an infolding of the neural plate (the neural fold) that then seals to form the neural tube[XAO]. The earliest recognizable dorsal ectodermal primordium of the central nervous system present near the end of gastrulation before infolding to form the neural keel; consists of a thickened pseudostratified epithelium[ZFA].
The earliest recognizable dorsal ectodermal primordium of the central nervous system present near the end of gastrulation before infolding to form the neural keel; consists of a thickened pseudostratified epithelium. Kimmel et al, 1995.[TAO]
(...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...).[well established][VHOG]
@@ -46063,34 +46203,34 @@ MH: sexual subtypes should probably be logically defined based on sexual process
neural plate
https://upload.wikimedia.org/wikipedia/commons/8/8f/Neural_Crest.png
-
+
-
+
-
+
-
+
GOTAX:0000352
-
+
Wikipedia
-
+
Bgee:AN
@@ -46155,7 +46295,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process
-
+
The paraxial mesoderm is the mesoderm located bilaterally adjacent to the notochord and neural tube[GO].
Mesoderm lateral to the neural tube and notochord that is divided into cranial and post-cranial portions. The trunk portions further segment into somites.[AAO]
Presently, Cephalochordata, Urochordata, and Vertebrata are placed as subphyla of the phylum Chordata, in which the overall organization of embryonic tissues (dorsal hollow nerve cord, ventral digestive tract, axial notochord, and bilateral paraxial mesoderm) is largely conserved. In contrast, the echinoderms and hemichordates are sister groups of the chordates and they lack the notochord and paraxial mesoderm. Thus, the basic mesodermal organization of vertebrates must have appeared first in the common ancestor of the chordates.[well established][VHOG]
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paraxial mesoderm
http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png
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Bgee:AN
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lateral plate mesoderm
http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png
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EHDAA2
VHOG
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Bilateral groups of cells consisting of three rows: one row of endocardial precursors medially and two rows of myocardical precursors laterally. The two populations fuse at the midline to form the heart rudiment or cone.
should probably be merged with heart rudiment.
Bilateral groups of cells consisting of three rows: one row of endocardial precursors medially and two rows of myocardical precursors laterally. The two populations fuse at the midline between 21 and 26 somites to form the heart rudiment or cone. Stainier 2001.[TAO]
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heart primordium
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ZFA
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ZFA
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XAO
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Ventral somitic compartment that is a precursor of the axial skeleton[XAO]. Sclerotomes eventually differentiate into the vertebrae and most of the skull. The caudal (posterior) half of one sclerotome fuses with the rostral (anterior) half of the adjacent one to form each vertebra. From their initial location within the somite, the sclerotome cells migrate medially towards the notochord. These cells meet the sclerotome cells from the other side to form the vertebral body. From this vertebral body, sclerotome cells move dorsally and surround the developing spinal cord, forming the vertebral arch[WP].
Skeletogenic portion of somites.[AAO]
The vertebrate sclerotome has no equivalent in amphioxus and is a novelty linked with the evolution of the axial skeleton.[well established][VHOG]
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sclerotome
http://upload.wikimedia.org/wikipedia/commons/9/96/Gray65.png
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VHOG:0000680
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ZFA
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The part of the coelom in the embryo between the somatopleuric and splanchnopleuric mesoderm; the principal body cavities of the trunk (thoracic, abdominal, and pelvic) arise from this embryonic part of the coelom.
consider merging with coelom. TODO - add spatial relationships to halves of LPM. Note the OG places XAO and ZFA coelem terms here. editor note: TODO check ZFA, which appears to be a structure present in adults
(...) I regard it unlikely that coeloms of all bilaterian animals are comparable and evolved very early. Considering all these questions, few convincing characters concerning the evolution of body cavities remain to be named. (...) A segmental coelom appears to have evolved at least two times, in Annelida and in Myomerata (Acrania and Craniota).[well established][VHOG]
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intraembryonic coelom
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Wikipedia
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A specific region of the lateral mesoderm that will form the primary beating heart tube. In mammals the primary heart field gives rise to the left ventricle.
this term denotes the primary heart field; GO:0003128 denotes the superclass of primary and secondary: specific region of the lateral mesoderm into the area which will form the primary beating heart tube[GO:0003138]
XAO:0004185
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UBERON:0004140
primary heart field
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GO:0003128
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https://orcid.org/0000-0003-3308-6245
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An epithelial tube that will give rise to the mature heart.
the paired, longitudinal, endothelial-lined channels formed from the cardiogenic mesoderm in embryonic development; angiogenic cell clusters (aka angioblastic cords) located in a horse-shoe shape configuration in the cardiogenic plate coalesce to form the right and left endocardial heart tubes which then fuse in cephalo-caudal direction to form a single primitive heart tube.
AAO:0010411
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heart tube
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ZFA-modified
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A specialized form of connective tissue in which the extracellular matrix is firm, providing the tissue with resilience, and/or mineralized and that functions in mechanical and structural support.[VSAO].
A specialized form of connective tissue in which the extracellular matrix is firm, providing the tissue with resilience, and/or mineralized and that functions in mechanical and structural support.[VSAO]
EMAPA:37744
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Four classes of mineralized tissues are found in vertebrates: bone, cartilage, dentine, and enamel. We think of cartilage and bone as skeletal tissues and of enamel and dentine as dental tissues, but enamel and dentine arose evolutionarily together with bone as skeletal tissues in the dermal skeleton (exoskeleton) of early vertebrates. Scales and teeth of sharks are examples of dermal skeletal elements that are still composed of the three ancient components-enamel, dentine, and bone. Cartilage, on the other hand, provided the basis for the second vertebrate skeletal system, the endoskeleton (Smith and Hall, 1990; Hall, 1998a,b). some invertebrate skeletal tissues have surprisingly bone-like features. Examples include chondrocytes interconnected by cell processes in cephalopod cartilages (Cole and Hall, 2004a,b), and the calcium phosphate layer in the shells of brachiopods (Rodland et al., 2003). However, neither bone nor mineralized cartilage have been found in invertebrates. Editors notes: TODO - develops_from
skeletal tissue
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2012-08-14
VSAO:0000015
VSAO
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Organ consisting of skeletal tissue. Encompasses whole bones, fused bones, cartilaginious elements, teeth, dermal denticles.
Organ entity that is typically involved in mechanical support and may have different skeletal tissue compositions at different stages.[VSAO]
Organ entity that may have different tissue compositions at different stages and is typically involved in mechanical support.[TAO]
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skeletal element
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VSAO
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UBERON:0004770
articular system
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FMA
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Mesenchyme that is part of a developing trunk.
EFO:0003485
EHDAA2:0002092
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trunk mesenchyme
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EHDAA2
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Multi-tissue structure that arises from the heart rudiment and will become the heart tube.
EHDAA2:0001512
EHDAA:424
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primitive heart tube
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ZFA
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A delimited region of dense mesenchyme within looser mesenchyme.
AEO:0000148
EHDAA2_RETIRED:0003148
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UBERON:0005856
developing mesenchymal condensation
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AEO-modified-relation
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The notochordal plate is the dorsal part of the notochordal process when the ventral portion breaks down. It is continuous laterally with the endoderm that composes the roof of the primitive foregut and is in contact dorsally with the neural tube. The folding off of the notochordal plate gives rise to the notochord.
TODO - check ordering; awaiting confirmation from JB
The notochordal plate is the dorsal part of the notochordal process when the ventral portion breaks down. It is continuous laterally with the endoderm that composes the roof of the primitive foregut and is in contact dorsally with the neural tube. The folding off of the notochordal plate gives rise to the notochord. [Carson_JL, Dehart_DB, Developmental_Dynamics_(1994)_201:_260-278, Gesteland_K_and_Schoenwolf_GC, Inagaki_T, Morphogenesis_of_the_murine_node_and_notochordal_plate, The_prechordal_plate, Vrablic_T, see_Mueller_F_and_O'Rahilly_R, the_rostral_end_of_the_notochord_and_nearby_median_features_in_staged_human_embryos._Cells_Tissues_Organs_(2003)_173:_1-20_and_Sulik_K][VHOG]
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notochordal plate
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EHDAA2
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A midline cellular cord formed from the migration of mesenchymal cells from the primitive knot.
EHDAA2:0001279
EHDAA:224
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The notochordal process grows cranially until it reaches the prechordal plate, the future site of the mouth. In this area the ectoderm is attached directly to the endoderm without intervening mesoderm. This area is known as the oropharyngeal membrane, and it will break down to become the mouth. At the other end of the primitive streak the ectoderm is also fused directly to the endoderm; this is known as the cloacal membrane (proctodeum), or primordial anus.
notochordal process
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EHDAA2
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