From 10cdffd8ad91a3f41c0e8494d7ebbf692191bae7 Mon Sep 17 00:00:00 2001 From: bvarner-ebi <95643797+bvarner-ebi@users.noreply.github.com> Date: Thu, 24 Aug 2023 09:28:30 +0100 Subject: [PATCH] release 2023-08-24 --- cl-base.owl | 1013 +- cl.obo | 5435 +++--- patterns/definitions.owl | 4 +- src/ontology/diffs/cl-diff.md | 14082 +++++++++++----- .../reports/cl-edit.owl-obo-report.tsv | 11 +- .../subsets/blood_and_immune_upper_slim.json | 678 +- .../subsets/blood_and_immune_upper_slim.obo | 159 +- .../subsets/blood_and_immune_upper_slim.owl | 995 +- .../subsets/blood_and_immune_upper_slim.tsv | 807 +- src/ontology/subsets/eye_upper_slim.json | 715 +- src/ontology/subsets/eye_upper_slim.obo | 169 +- src/ontology/subsets/eye_upper_slim.owl | 1597 +- src/ontology/subsets/eye_upper_slim.tsv | 662 +- .../general_cell_types_upper_slim.json | 934 +- .../subsets/general_cell_types_upper_slim.obo | 238 +- .../subsets/general_cell_types_upper_slim.owl | 1171 +- .../subsets/general_cell_types_upper_slim.tsv | 578 +- subsets/blood_and_immune_upper_slim.json | 678 +- subsets/blood_and_immune_upper_slim.obo | 159 +- subsets/blood_and_immune_upper_slim.owl | 995 +- subsets/blood_and_immune_upper_slim.tsv | 807 +- subsets/eye_upper_slim.json | 715 +- subsets/eye_upper_slim.obo | 169 +- subsets/eye_upper_slim.owl | 1597 +- subsets/eye_upper_slim.tsv | 662 +- subsets/general_cell_types_upper_slim.json | 934 +- subsets/general_cell_types_upper_slim.obo | 238 +- subsets/general_cell_types_upper_slim.owl | 1171 +- subsets/general_cell_types_upper_slim.tsv | 578 +- 29 files changed, 21636 insertions(+), 16315 deletions(-) diff --git a/cl-base.owl b/cl-base.owl index 4757a968a..cc6c6a1d8 100644 --- a/cl-base.owl +++ b/cl-base.owl @@ -17,7 +17,7 @@ xmlns:ubprop="http://purl.obolibrary.org/obo/ubprop#" xmlns:oboInOwl="http://www.geneontology.org/formats/oboInOwl#"> - + An ontology of cell types. Cell Ontology @@ -33,7 +33,7 @@ See PMID:15693950, PMID:12799354, PMID:20123131, PMID:21208450; Contact Alexander Diehl, addiehl@buffalo.edu, University at Buffalo. - 2023-07-20 + 2023-08-24 @@ -51,7 +51,9 @@ - + + symbol + @@ -664,6 +666,12 @@ + + + + + + @@ -1514,6 +1522,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u mature oocyte ovum egg cell + https://www.swissbiopics.org/api/image/Egg_cell.svg @@ -1914,9 +1923,9 @@ Covers cells actively being cultured or stored in a quiescent state for future u FMA:86475 MESH:D006412 VHOG:0001485 - HSC blood forming stem cell hemopoietic stem cell + HSC colony forming unit hematopoietic @@ -1939,6 +1948,12 @@ Covers cells actively being cultured or stored in a quiescent state for future u PMID:19022770 http://en.wikipedia.org/wiki/Hematopoietic_stem_cell + + + + HSC + + @@ -1977,6 +1992,18 @@ Covers cells actively being cultured or stored in a quiescent state for future u GOC:add ISBN:0721601464 + + + + BFU-E + + + + + + CFU-E + + @@ -2069,6 +2096,12 @@ Covers cells actively being cultured or stored in a quiescent state for future u http://en.wikipedia.org/wiki/Monoblast http://www.copewithcytokines.de + + + + CFU-M + + @@ -2440,10 +2473,10 @@ Covers cells actively being cultured or stored in a quiescent state for future u A progenitor cell committed to myeloid lineage, including the megakaryocyte and erythroid lineages. BTO:0004730 - CMP common myeloid precursor CFU-GEMM CFU-S + CMP colony forming unit granulocyte, erythrocyte, macrophage, and megakaryocyte multipotential myeloid stem cell myeloid stem cell @@ -2468,21 +2501,24 @@ Covers cells actively being cultured or stored in a quiescent state for future u - - CMP + + CFU-GEMM ISBN:0878932437 + - CFU-GEMM + CFU-S ISBN:0878932437 + - CFU-S + CMP ISBN:0878932437 + @@ -2588,10 +2624,10 @@ Covers cells actively being cultured or stored in a quiescent state for future u A oligopotent progenitor cell committed to the lymphoid lineage. - CLP common lymphocyte precursor common lymphocyte progenitor common lymphoid precursor + CLP ELP committed lymphopoietic stem cell early lymphocyte progenitor @@ -2617,6 +2653,18 @@ Covers cells actively being cultured or stored in a quiescent state for future u PMID:10407577 PMID:16551251 + + + + CLP + + + + + + ELP + + @@ -3047,6 +3095,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u epithelial cell + https://www.swissbiopics.org/api/image/Epithelial_cells.svg @@ -5030,7 +5079,6 @@ Covers cells actively being cultured or stored in a quiescent state for future u An hexagonal, flattened, mitochondria-rich endothelial cell that forms a monolayer on the posterior surface of the cornea (the corneal endothelium). Corneal endothelial cells are derived from the neural crest and are responsible for keeping the cornea transparent by maintaining the tissue in a semi-dry state through the action of their ionic pumps and tight junction barrier. GOC:tfm - MESH:A09.371.060.067.31 PMID:21976958 PMID:23284695 PMID:34741068 @@ -5066,10 +5114,10 @@ Covers cells actively being cultured or stored in a quiescent state for future u BTO:0002625 BTO:0003298 FMA:70546 - BMSC bone marrow stromal cells colony-forming unit-fibroblast marrow stromal cells + BMSC CFU-F MSC mesenchymal precursor cell @@ -5108,11 +5156,24 @@ Covers cells actively being cultured or stored in a quiescent state for future u marrow stromal cells PMID:11378515 + + + + BMSC + + + + + + CFU-F + + MSC PMID:11378515 + @@ -5432,7 +5493,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u A cell capable of processing and presenting lipid and protein antigens to T cells in order to initiate an immune response. - APC + APC Note change of name; nearly all somatic cells can present antigens to T cells via MHC Class I complexes leading to effector responses, but professional antigen presenting cells constitutively express MHC Class II as well as costimulatory molecules, and thus can initiate immune responses via T cells. professional antigen presenting cell @@ -5444,6 +5505,12 @@ Covers cells actively being cultured or stored in a quiescent state for future u GOC:add ISBN:0781735149 + + + + APC + + @@ -5812,26 +5879,11 @@ Covers cells actively being cultured or stored in a quiescent state for future u - - - - - - - - - - - - - acid secreting cell + + https://github.com/obophenotype/cell-ontology/issues/427 + obsolete acid secreting cell + true - - - - - true - @@ -5839,8 +5891,14 @@ Covers cells actively being cultured or stored in a quiescent state for future u - + + + + + + + A large, oval stomach epithelial cell with a central nucleus; source of gastric acid. Secretes HCl. BTO:0001780 FMA:62901 @@ -6681,6 +6739,7 @@ The modern definition of neurosecretion has evolved to include the release of an muscle fiber myocyte muscle cell + https://www.swissbiopics.org/api/image/Muscle_cells.svg @@ -6960,6 +7019,18 @@ The modern definition of neurosecretion has evolved to include the release of an The peripheral receptor for pain. Includes receptors which are sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli. All mammalian nociceptors are free nerve endings. MESH:D009619 + + + + nociceptor + https://meshb.nlm.nih.gov/record/ui?ui=D009619 + + + + + nocireceptor + https://www.thefreedictionary.com/nocireceptor + @@ -7226,6 +7297,7 @@ The modern definition of neurosecretion has evolved to include the release of an CALOHA:TS-0868 FMA:86740 photoreceptor cell + https://www.swissbiopics.org/api/image/Photoreceptor_cell.svg @@ -9583,7 +9655,7 @@ The modern definition of neurosecretion has evolved to include the release of an A cell derived from the specialized ectoderm flanking each side of the embryonic neural plate, which after the closure of the neural tube, forms masses of cells that migrate out from the dorsal aspect of the neural tube to spread throughout the body. - MESH:A16.254.600 + doi:10.1016/j.stem.2015.02.017 @@ -10189,6 +10261,7 @@ The modern definition of neurosecretion has evolved to include the release of an + A smooth muscle cell associated with the vasculature. VSMC @@ -11704,20 +11777,20 @@ The modern definition of neurosecretion has evolved to include the release of an - + A stem cell that gives rise to the follicle cells that surround the oocyte in female arthropods. somatic stem cell FBbt:00004903 follicle stem cell (sensu Arthropoda) - + - + https://github.com/obophenotype/cell-ontology/issues/1943 @@ -12590,7 +12663,7 @@ The modern definition of neurosecretion has evolved to include the release of an - + @@ -12603,14 +12676,14 @@ The modern definition of neurosecretion has evolved to include the release of an FBbt:00004904 follicle cell of egg chamber - + - + @@ -13724,11 +13797,13 @@ The modern definition of neurosecretion has evolved to include the release of an A cell from the outer syncytial layer of the trophoblast of an early mammalian embryo, directly associated with the maternal blood supply. It secretes hCG in order to maintain progesterone secretion and sustain a pregnancy. FMA:83043 - plasmidotrophoblast - syncytial trophoblast - syntrophoblast + syncytial trophoblast cell + syncytiotrophoblastic cell + plasmidotrophoblast cell + syntrophoblast cell syncytiotrophoblast cell + https://github.com/obophenotype/cell-ontology/issues/2100 @@ -13737,6 +13812,18 @@ The modern definition of neurosecretion has evolved to include the release of an GOC:tfm ISBN:0323052908 + + + + syncytial trophoblast cell + PMID:11787150 + + + + + syncytiotrophoblastic cell + PMID:21733368 + @@ -13808,18 +13895,18 @@ The modern definition of neurosecretion has evolved to include the release of an - + A neuron that develops during the early segmentation stages in teleosts, before the neural tube is formed. primary neuron (sensu Teleostei) - + - + https://github.com/obophenotype/cell-ontology/pull/1950 @@ -13902,18 +13989,18 @@ The modern definition of neurosecretion has evolved to include the release of an - + A neuron of teleosts that develops later than a primary neuron, typically during the larval stages. secondary neuron (sensu Teleostei) - + - + https://github.com/obophenotype/cell-ontology/pull/1950 @@ -14024,6 +14111,7 @@ The modern definition of neurosecretion has evolved to include the release of an These cells are also reportedly CD4-negative and CD200-positive. They are also capable of producing CD40L and IFN-gamma. neuron + https://www.swissbiopics.org/api/image/Neuron_cells.svg @@ -14411,7 +14499,6 @@ The modern definition of neurosecretion has evolved to include the release of an An immature, nucleated erythrocyte occupying the stage of erythropoeisis that follows formation of erythroid progenitor cells. This cell is CD71-positive, has both a nucleus and a nucleolus, and lacks hematopoeitic lineage markers. ISBN:0721601464 - MESH:A11.118.290.350.200 PMID:1638021 @@ -14448,6 +14535,7 @@ The modern definition of neurosecretion has evolved to include the release of an metazoan cell animal cell + https://www.swissbiopics.org/api/image/Animal_cells.svg @@ -14961,12 +15049,12 @@ The modern definition of neurosecretion has evolved to include the release of an A hematopoietic progenitor cell that is committed to the granulocyte and monocyte lineages. These cells are CD123-positive, and do not express Gata1 or Gata2 but do express C/EBPa, and Pu.1. CFU-C , Colony forming unit in culture - CFU-GM - GMP colony forming unit granulocyte macrophage granulocyte-macrophage progenitor granulocyte/monocyte precursor granulocyte/monocyte progenitor + CFU-GM + GMP Originally described in the dendritic cell ontology (DC_CL:0000042)(PMID:19243617). GMPs are reportedly CD16-positive, CD32-positive, CD34-positive, CD38-positive, CD45RA-positive, CD110-negative, CD117-positive, CD123-positive, and SCA1-negative. granulocyte monocyte progenitor cell @@ -15003,7 +15091,7 @@ The modern definition of neurosecretion has evolved to include the release of an - CFU-GM + colony forming unit granulocyte macrophage ISBN:0721601464 PMCID:PMC2213186 PMCID:PMC548021 @@ -15011,26 +15099,28 @@ The modern definition of neurosecretion has evolved to include the release of an - GMP + granulocyte-macrophage progenitor ISBN:0721601464 PMCID:PMC2213186 PMCID:PMC548021 - - colony forming unit granulocyte macrophage + + CFU-GM ISBN:0721601464 PMCID:PMC2213186 PMCID:PMC548021 + - - granulocyte-macrophage progenitor + + GMP ISBN:0721601464 PMCID:PMC2213186 PMCID:PMC548021 + @@ -15553,6 +15643,7 @@ The modern definition of neurosecretion has evolved to include the release of an A cell that originates in the neural crest, that has certain cytochemical and ultrastructural characteristics and is found scattered throughout the body; types include melanocytes, the cells of the chromaffin system, and cells in the hypothalamus, hypophysis, thyroid, parathyroids, lungs, gastrointestinal tract, and pancreas. This cell type concentrates the amino acid precursors of certain amines and decarboxylate them, forming amines that function as regulators and neurotransmitters. This cell type produces substances such as epinephrine, norepinephrine, dopamine, serotonin, enkephalin, somatostatin, neurotensin, and substance P, the actions of which may affect contiguous cells, nearby groups of cells, or distant cells, thus functioning as local or systemic hormones. The name is an acronym for amine precursor uptake and decarboxylation cell. BTO:0003866 FMA:83114 + MESH:D001078 APUD cell amine precursor uptake and decarboxylation cell @@ -15562,7 +15653,6 @@ The modern definition of neurosecretion has evolved to include the release of an A cell that originates in the neural crest, that has certain cytochemical and ultrastructural characteristics and is found scattered throughout the body; types include melanocytes, the cells of the chromaffin system, and cells in the hypothalamus, hypophysis, thyroid, parathyroids, lungs, gastrointestinal tract, and pancreas. This cell type concentrates the amino acid precursors of certain amines and decarboxylate them, forming amines that function as regulators and neurotransmitters. This cell type produces substances such as epinephrine, norepinephrine, dopamine, serotonin, enkephalin, somatostatin, neurotensin, and substance P, the actions of which may affect contiguous cells, nearby groups of cells, or distant cells, thus functioning as local or systemic hormones. The name is an acronym for amine precursor uptake and decarboxylation cell. GOC:tfm ISBN:0721662544 - MESH:A11.070 @@ -15898,6 +15988,7 @@ The modern definition of neurosecretion has evolved to include the release of an FMA:62934 FMA:83132 + MESH:D004759 Kulchitsky cell argentaffin cell enterochromaffin cell @@ -15908,7 +15999,6 @@ The modern definition of neurosecretion has evolved to include the release of an A subtype of enteroendocrine cells found in the gastrointestinal mucosa, particularly in the glands of pyloric antrum; duodenum; and ileum. These cell type secretes serotonin and some neurotransmitters including enkephalins and substance P. Their secretory granules stain readily with silver (argentaffin stain). - MESH:A03.492.766.440.250 PMID:9505449 @@ -16454,7 +16544,6 @@ The modern definition of neurosecretion has evolved to include the release of an A specialized osteoclast associated with the absorption and removal of cementum. GOC:add - MESH:A11.329.679 @@ -16625,8 +16714,8 @@ The modern definition of neurosecretion has evolved to include the release of an An erythrocyte lacking a nucleus. - RBC red blood cell + RBC enucleate erythrocyte @@ -16642,6 +16731,12 @@ The modern definition of neurosecretion has evolved to include the release of an GOC:add GOC:tfm + + + + RBC + + @@ -17058,8 +17153,8 @@ The modern definition of neurosecretion has evolved to include the release of an - EoP CFU-Eo + EoP colony forming unit eosinophil eosinophil stem cell These cells are CD34-positive, CD45RA-negative, CD71-negative, and lineage-negative (CD2, CD3 epsilon, CD4, CD5, CD8a, CD14, CD19, CD20, integrin alpha-M, NCAM-1, SCA-1, Ly6G, Ly76). @@ -17073,10 +17168,17 @@ The modern definition of neurosecretion has evolved to include the release of an - + + CFU-Eo + + + + + EoP PMCID:PMC2212039 PMCID:PMC2626675 + @@ -17664,20 +17766,65 @@ The modern definition of neurosecretion has evolved to include the release of an - + - - Granule cell that is part of the olfactory bulb. + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A granule cell that has a soma located in an olfactory bulb granule cell layer. An olfactory granule cell is an interneuron that lacks an axon, makes reciprocal dendro-dendritic synapses with mitral cells and tufted cells and is involved in the fine spatio-temporal tuning of the responses of these principal olfactory bulb neurons to odors. + olfactory bulb granule cell + Granule cells are the most abundant neuronal population in the olfactory bulb and are continuously renewed throughout life. olfactory granule cell - Granule cell that is part of the olfactory bulb. + A granule cell that has a soma located in an olfactory bulb granule cell layer. An olfactory granule cell is an interneuron that lacks an axon, makes reciprocal dendro-dendritic synapses with mitral cells and tufted cells and is involved in the fine spatio-temporal tuning of the responses of these principal olfactory bulb neurons to odors. GOC:mah + doi:10.1038/s41598-018-27692-8 + + + + + olfactory bulb granule cell + doi:10.1038/s41598-018-27692-8 + + + + + Granule cells are the most abundant neuronal population in the olfactory bulb and are continuously renewed throughout life. + doi:10.1038/s41598-018-27692-8 @@ -19690,6 +19837,8 @@ radial glial cells acting as neural progenitors throughout life. Specialized ependymal cell that produces the cerebrospinal fluid from the blood and secretes it into the lumen of the brain and spinal chord. + 2023-08-04T08:48:30Z + choroid plexus cell FMA:70549 epithelial cell of choroid plexus choroid plexus epithelial cell @@ -19703,6 +19852,12 @@ radial glial cells acting as neural progenitors throughout life. JB:jb PMID:9550134 + + + + choroid plexus cell + DOI:10.1101/2022.10.12.511898 + @@ -20830,7 +20985,7 @@ radial glial cells acting as neural progenitors throughout life. - + @@ -20848,7 +21003,7 @@ radial glial cells acting as neural progenitors throughout life. FMB cone bipolar cell type 2 cone bipolar cell (sensu Mus) - + @@ -20868,7 +21023,7 @@ radial glial cells acting as neural progenitors throughout life. - + PMID:27565351 @@ -23027,6 +23182,12 @@ radial glial cells acting as neural progenitors throughout life. GOC:tfm ISBN:0781735149 + + + + gd T cell + + @@ -26944,6 +27105,7 @@ radial glial cells acting as neural progenitors throughout life. + A central nervous system macrophage found in small blood vessels in the brain. Markers include CD14+CD16+CD163+. Markers: Human/monkey, mice: CD163. Human: CD14+CD16+CD163+. perivascular macrophage @@ -29829,10 +29991,10 @@ radial glial cells acting as neural progenitors throughout life. A lymphoid progenitor cell that is found in bone marrow, gives rise to B cells, T cells, natural killer cells and dendritic cells, and has the phenotype Lin-negative, Kit-positive, Sca-1-positive, FLT3-positive, CD34-positive, CD150 negative, and GlyA-negative. - ELP - LMPP lymphoid-primed multipotent progenitor + ELP GMLP + LMPP Markers are associated with mouse cells. ELP transcription factors include E2A-positive, Ikaros-positive, EBF-negative, Pax5-negative, PU.1-negative. early lymphoid progenitor @@ -29853,11 +30015,24 @@ radial glial cells acting as neural progenitors throughout life. GO_REF:0000031 PMID:19022770 + + + + ELP + + GMLP PMID:18371378 + + + + + + LMPP + @@ -35744,10 +35919,10 @@ radial glial cells acting as neural progenitors throughout life. A progenitor cell committed to myeloid lineage, including the megakaryocyte and erythroid lineages. These cells are CD34-positive, and express Gata1, Gata2, C/EBPa, and Pu.1. - CMP common myeloid precursor, CD34-positive CFU-GEMM CFU-S + CMP colony forming unit granulocyte, erythrocyte, macrophage, and megakaryocyte multipotential myeloid stem cell myeloid stem cell @@ -35770,21 +35945,24 @@ radial glial cells acting as neural progenitors throughout life. - - CMP + + CFU-GEMM ISBN:0878932437 + - CFU-GEMM + CFU-S ISBN:0878932437 + - CFU-S + CMP ISBN:0878932437 + @@ -36204,6 +36382,18 @@ radial glial cells acting as neural progenitors throughout life. GOC:add ISBN:0721601464 + + + + BFU-E + + + + + + CFU-E + + @@ -40850,11 +41040,11 @@ radial glial cells acting as neural progenitors throughout life. A neuroendocrine cell found in the epithelium of the lungs and respiratory tract. This cell type is rounded or elliptical in shape, situated mainly in the basal part of the epithelium; regulates bronchial secretion, smooth muscle contraction, lobular growth, ciliary activity and chemoreception. Cell has an electron-lucent cytoplasm, contains numerous dense-cored vesicles with a clear halo between the core and the limiting membrane. 2010-06-28T08:24:30Z - P cell FMA:14118 Kultschitzky cell of bronchiole bronchiolar Kulchitsky cell respiratory enterochromaffin cell + P cell Feyrter cell @@ -40865,6 +41055,12 @@ radial glial cells acting as neural progenitors throughout life. ISBN:0412046911 ISBN:0517223651 + + + + P cell + + @@ -45017,7 +45213,7 @@ radial glial cells acting as neural progenitors throughout life. 2010-08-30T02:00:42Z FMA:86577 - HpSC + HpSC hepatic stem cell https://github.com/obophenotype/cell-ontology/issues/800 @@ -45036,7 +45232,7 @@ radial glial cells acting as neural progenitors throughout life. - + HpSC PMID:18442648 @@ -48061,7 +48257,7 @@ radial glial cells acting as neural progenitors throughout life. - + @@ -48076,14 +48272,14 @@ radial glial cells acting as neural progenitors throughout life. Type A cells are usually round and located in the upper part of the synovial intima. type A synovial cell - + - + PMID:10770586 @@ -52672,6 +52868,12 @@ radial glial cells acting as neural progenitors throughout life. GOC:tfm http://www.immgen.org/index_content.html + + + + T.4SP24-.Th + + @@ -53227,11 +53429,11 @@ radial glial cells acting as neural progenitors throughout life. 2010-11-10T02:51:34Z - O-2A/OPC - O2A/OPC oligodendrocyte-type 2 astrocyte (O-2A) progenitor cell oligodendrocyte/type-2 astrocyte progenitor cell MESH:D000073637 + O-2A/OPC + O2A/OPC This cell type can be purified from optic nerves and other regions of the embryonic, postnatal and adult rat CNS and can be differentiated in vitro to oligodendrocytes and type-2 astrocytes. Some references use the terms 'oligodendrocyte precursor cell' and 'oligodendrocyte type-2 astrocyte (O-2A) progenitor' to refer to the same entity (e.g., PMID:10704434), while others describe an oligodendrocyte type-2 astrocyte (O-2A) progenitor cell as the precurosr to oligodendrocyte- and type-2 astrocyte- progenitor cells (e.g, ISBN:9780702028991). oligodendrocyte precursor cell @@ -53251,27 +53453,29 @@ radial glial cells acting as neural progenitors throughout life. - O-2A/OPC - PMID:24133281 + oligodendrocyte-type 2 astrocyte (O-2A) progenitor cell + PMID:2253328 - O2A/OPC - PMID:11756508 + oligodendrocyte/type-2 astrocyte progenitor cell + + PMID:24133281 - - oligodendrocyte-type 2 astrocyte (O-2A) progenitor cell - PMID:2253328 + + O-2A/OPC + PMID:24133281 + - - oligodendrocyte/type-2 astrocyte progenitor cell - - PMID:24133281 + + O2A/OPC + PMID:11756508 + @@ -54215,6 +54419,12 @@ radial glial cells acting as neural progenitors throughout life. GOC:tfm http://www.immgen.org/index_content.html + + + + MF.BM + + @@ -60362,8 +60572,8 @@ radial glial cells acting as neural progenitors throughout life. A stem cell that can give rise to multiple cell types (i.e. smooth muscle, endothelial) in the developing heart. 2011-07-11T03:15:38Z - CPC cardiovascular progenitor cell + CPC Discrepancy in develops from origins prevents me from making the assertion that cardioblasts give rise to all instances of cardiocytes as we state cardiac muscle cells develop from cardiac myoblast, which in turn develop from muscle stem cell. cardioblast @@ -60377,15 +60587,16 @@ radial glial cells acting as neural progenitors throughout life. - CPC + cardiovascular progenitor cell + PMID:17519333 PMID:19745164 - - cardiovascular progenitor cell - PMID:17519333 + + CPC PMID:19745164 + @@ -62618,9 +62829,9 @@ radial glial cells acting as neural progenitors throughout life. https://orcid.org/0000-0002-5260-9315 type I BAMS:1045 - I-2 inner alpha retinal ganglion cell cell + I-2 CL:0004120 retinal ganglion cell A1 @@ -62760,10 +62971,10 @@ radial glial cells acting as neural progenitors throughout life. A retinal ganglion A cell with dense arbor near soma. https://orcid.org/0000-0001-7258-9596 https://orcid.org/0000-0002-5260-9315 - type I - I-1 outer alpha retinal ganglion cell cell + I-1 + type I CL:0004138 retinal ganglion cell A2 @@ -63076,7 +63287,6 @@ radial glial cells acting as neural progenitors throughout life. - An amacrine cell with a small, asymteric dendritic field. https://orcid.org/0000-0001-7258-9596 https://orcid.org/0000-0002-5260-9315 @@ -63166,7 +63376,7 @@ radial glial cells acting as neural progenitors throughout life. - + @@ -63291,7 +63501,6 @@ radial glial cells acting as neural progenitors throughout life. - @@ -63361,7 +63570,7 @@ radial glial cells acting as neural progenitors throughout life. - + @@ -63532,7 +63741,6 @@ radial glial cells acting as neural progenitors throughout life. - @@ -63593,7 +63801,6 @@ radial glial cells acting as neural progenitors throughout life. - @@ -63626,7 +63833,6 @@ radial glial cells acting as neural progenitors throughout life. - @@ -63659,7 +63865,6 @@ radial glial cells acting as neural progenitors throughout life. - @@ -63698,7 +63903,6 @@ radial glial cells acting as neural progenitors throughout life. - @@ -63825,7 +64029,6 @@ radial glial cells acting as neural progenitors throughout life. - @@ -63852,7 +64055,6 @@ radial glial cells acting as neural progenitors throughout life. - @@ -63879,7 +64081,6 @@ radial glial cells acting as neural progenitors throughout life. - @@ -63906,7 +64107,6 @@ radial glial cells acting as neural progenitors throughout life. - @@ -63933,7 +64133,6 @@ radial glial cells acting as neural progenitors throughout life. - @@ -63960,7 +64159,6 @@ radial glial cells acting as neural progenitors throughout life. - @@ -64061,7 +64259,6 @@ radial glial cells acting as neural progenitors throughout life. - An amicrine that stratifies dendrites at two and only two locations. https://orcid.org/0000-0001-7258-9596 https://orcid.org/0000-0002-5260-9315 @@ -64082,7 +64279,6 @@ radial glial cells acting as neural progenitors throughout life. - An amicrine that has a narrow dendritic field. https://orcid.org/0000-0001-7258-9596 https://orcid.org/0000-0002-5260-9315 @@ -64103,7 +64299,6 @@ radial glial cells acting as neural progenitors throughout life. - An amicrine that has a medium dendritic field. https://orcid.org/0000-0001-7258-9596 @@ -64126,7 +64321,6 @@ radial glial cells acting as neural progenitors throughout life. - An amicrine that has a wide dendritic field. https://orcid.org/0000-0001-7258-9596 @@ -64478,10 +64672,10 @@ radial glial cells acting as neural progenitors throughout life. A ciliated epithelial cell with many cilia. - MCC multi-ciliated cell multiciliated cell multiciliated epithelial cell + MCC multi-ciliated epithelial cell @@ -64490,6 +64684,12 @@ radial glial cells acting as neural progenitors throughout life. A ciliated epithelial cell with many cilia. CL:CVS + + + + MCC + + @@ -65905,18 +66105,18 @@ Covers cells actively being cultured or stored in a quiescent state for future u - + A skeletal muscle satellite cell that has become mitotically active - typically following muscle damage. activated skeletal muscle satellite cell - + - + More accurately - transformation_of ? @@ -66352,6 +66552,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u + Mural cells are pericytes and the vascular smooth muscle cells (vSMCs) of the microcirculation. @@ -69854,9 +70055,9 @@ Covers cells actively being cultured or stored in a quiescent state for future u 2022-03-22T09:03:15Z - MedRC lymph node medullary reticular cell medullary reticular cell of lymph node + MedRC Origin and phenotype of medullary reticular cells are less well understood in humans than in mice. medullary reticular cell @@ -69877,7 +70078,7 @@ Covers cells actively being cultured or stored in a quiescent state for future u - + MedRC @@ -72062,16 +72263,12 @@ plexiform layer using GABA. + - - - - - - - - - + + + + A supportive cell with a small, oval-shaped body and one to five telopodes. Telopodes are cytoplasmic protrusions from tens to hundreds of micrometers long and mostly below 0.2 microns of caliber. @@ -72130,16 +72327,12 @@ plexiform layer using GABA. + - - - - - - - - - + + + + A lymphocyte that has gotten larger after being stimulated by an antigen. 2022-08-17T14:20:01Z @@ -73430,10 +73623,53 @@ plexiform layer using GABA. + + + + + + + + + + + + + + + + + + + + A neuroendocrine cell that is part of respiratory epithelium of the lung and is involved in the sensory detection of environmental stimuli, including hypoxia, nicotine and air pressure. Ultrastructurally, this cell type is characterized by the presence of cytoplasmic dense core granules, which are considered the storage sites of amine and peptide hormones. Lung neuroendocrine cells are innervated and appear as solitary cells or as clustered masses, localized at airway bifurcation sites, called neuroepithelial bodies that can release serotonin in response to hypoxia and interact with sensory nerve terminals. Lung neuroendocrine cells also function as reserve stem cells that repair the surrounding epithelium after injury. + pulmonary neuroendocrine cell + PNEC lung neuroendocrine cell + + + + A neuroendocrine cell that is part of respiratory epithelium of the lung and is involved in the sensory detection of environmental stimuli, including hypoxia, nicotine and air pressure. Ultrastructurally, this cell type is characterized by the presence of cytoplasmic dense core granules, which are considered the storage sites of amine and peptide hormones. Lung neuroendocrine cells are innervated and appear as solitary cells or as clustered masses, localized at airway bifurcation sites, called neuroepithelial bodies that can release serotonin in response to hypoxia and interact with sensory nerve terminals. Lung neuroendocrine cells also function as reserve stem cells that repair the surrounding epithelium after injury. + PMID:33355253 + doi:10.3109/01902148209069653 + doi:10.7554/eLife.78216 + + + + + pulmonary neuroendocrine cell + PMID:33355253 + + + + + PNEC + PMID:33355253 + + @@ -90230,12 +90466,12 @@ plexiform layer using GABA. L5 ET glut A glutamatergic neuron, with a soma found in the deeper portion of L5, that has long-range axonal projections including deep subcortical targets outside of the telencephalon and, in some cases, the spinal cord. While the L5 ET neuron projections are not limited to ET targets, they are clearly differentiated from the neuron subclasses whose projections are constrained to intratelencephalic (IT) targets. L5 ET neurons are generally the largest excitatory cortical neurons, typically having a thick apical dendrite with a prominent dendritic tuft in layer 1 and displaying burst-firing physiological characteristics. - L5b neuron subcerebral projection (SCPN) neuron Pyramidal tract-like (PT-l) burst-firing layer 5 neuron thick-tufted layer 5 (TTL5) pyramidal neuron pyramidal tract (PT) neuron + L5b neuron L5 extratelencephalic projecting glutamatergic cortical neuron @@ -90245,12 +90481,6 @@ plexiform layer using GABA. A glutamatergic neuron, with a soma found in the deeper portion of L5, that has long-range axonal projections including deep subcortical targets outside of the telencephalon and, in some cases, the spinal cord. While the L5 ET neuron projections are not limited to ET targets, they are clearly differentiated from the neuron subclasses whose projections are constrained to intratelencephalic (IT) targets. L5 ET neurons are generally the largest excitatory cortical neurons, typically having a thick apical dendrite with a prominent dendritic tuft in layer 1 and displaying burst-firing physiological characteristics. DOI:10.1101/2020.10.19.343129 - - - - L5b neuron - DOI:10.1016/j.neuron.2011.07.029 - @@ -90282,6 +90512,13 @@ plexiform layer using GABA. pyramidal tract (PT) neuron DOI:10.1038/nrn3469 + + + + L5b neuron + DOI:10.1016/j.neuron.2011.07.029 + + @@ -90756,43 +90993,43 @@ plexiform layer using GABA. - - - + + + A type of mouse mesothelial fibroblast that is derived from the neural crest, is localized on blood vessels, and is a key component of the pia and arachnoid membranes surrounding the brain. VLMC (Mus musculus) vascular leptomeningeal cell (Mmus) - + - + - + - + PMID:30096314 - + PMID:30096314 - + PMID:30096314 @@ -91286,27 +91523,19 @@ plexiform layer using GABA. - - - - - - - - - - - - A cell that is part of the choroid plexus. + OBSOLETE. A cell that is part of the choroid plexus. + - choroid plexus cell + https://github.com/obophenotype/cell-ontology/issues/2043 + obsolete choroid plexus cell + true - A cell that is part of the choroid plexus. + OBSOLETE. A cell that is part of the choroid plexus. DOI:10.1101/2022.10.12.511898 @@ -91903,8 +92132,8 @@ plexiform layer using GABA. A mesothelial fibroblast of the arachnoid barrier layer. Arachnoid barrier cells make up the tight-junctioned layer in the leptomeninx that functions as the physiologic barrier between the cerebrospinal fluid in the subarachnoid space and the fenestrated capillaries in the dura. - AB cell - ABC + AB cell + ABC arachnoid barrier cell @@ -91915,15 +92144,17 @@ plexiform layer using GABA. - + AB cell PMID:23298861 + - + ABC PMID:30096314 + @@ -92614,7 +92845,7 @@ plexiform layer using GABA. An interneuron located in the cerebral cortex that expresses the oxytocin receptor. These interneurons also express somatostatin. - OxtrINs + OxtrINs These cells were first identified in mouse. oxytocin receptor sst GABAergic cortical interneuron @@ -92632,9 +92863,10 @@ plexiform layer using GABA. - + OxtrINs PMID:25303526 + @@ -93410,10 +93642,10 @@ Midget bipolar cells (imb, fmb) have larger axon terminals at greater distances 2021-11-23T03:23:53Z - CAP1 capillary 1 cell - gCAP general capillary cell + CAP1 + gCAP alveolar capillary type 1 endothelial cell @@ -93431,14 +93663,21 @@ Midget bipolar cells (imb, fmb) have larger axon terminals at greater distances - gCAP + general capillary cell PMID:33057196 - - general capillary cell + + CAP1 + + + + + + gCAP PMID:33057196 + @@ -93459,10 +93698,10 @@ Midget bipolar cells (imb, fmb) have larger axon terminals at greater distances 2021-11-23T03:23:53Z CD34hi endothelial cells Car4+ capillary endothelial cell - aCAP aerocyte alveolar capillary cell capillary 2 cell + aCAP alveolar capillary type 2 endothelial cell @@ -93482,6 +93721,12 @@ Midget bipolar cells (imb, fmb) have larger axon terminals at greater distances aerocyte PMID:33057196 + + + + aCAP + + @@ -93502,13 +93747,13 @@ Midget bipolar cells (imb, fmb) have larger axon terminals at greater distances 2021-12-09T15:34:13Z - AF1 alveolar fibroblast alveolar fibroblast 1 lipid interstitial cell lipofibroblast matrix fibroblast 1 pulmonary lipofibroblast + AF1 alveolar type 1 fibroblast cell @@ -93525,6 +93770,12 @@ Midget bipolar cells (imb, fmb) have larger axon terminals at greater distances PMID:33707239 PMID:9074756 + + + + AF1 + + @@ -93542,13 +93793,13 @@ Midget bipolar cells (imb, fmb) have larger axon terminals at greater distances 2021-12-09T15:53:21Z - AF2 - MANC adventitial fibroblast alveolar fibroblast matrix fibroblast 2 mesenchymal alveolar niche cell type-2 associated stromal cell + AF2 + MANC alveolar type 2 fibroblast cell @@ -93563,6 +93814,18 @@ Midget bipolar cells (imb, fmb) have larger axon terminals at greater distances PMID:33208946 PMID:33624948 + + + + AF2 + + + + + + MANC + + @@ -95181,34 +95444,34 @@ Midget bipolar cells (imb, fmb) have larger axon terminals at greater distances A DRD1-expressing medium spiny neuron that is part of a matrix compartment of dorsal striatum. - + doi:10.1016/j.cub.2021.10.015 D1-matrix - + doi:10.1016/j.cub.2021.10.015 D1M - + doi:10.1016/j.cub.2021.10.015 matrix D1-MSN - + doi:10.1016/j.cub.2021.10.015 In Rhesus macaques, both matrix D1 and D2 medium spiny neuron cell types have been noted to have enriched gene expression of the following: EPHA4, GDA, STXBP6, and SEMA3E. Broadly understood, matrix MSNs receive neocortical inputs from the associative and sensorimotor cortex and give rise to the direct and indirect pathways. - + doi:10.1016/j.cub.2021.10.015 @@ -95245,34 +95508,34 @@ Midget bipolar cells (imb, fmb) have larger axon terminals at greater distances A DRD2-expressing medium spiny neuron that is part of a matrix compartment of dorsal striatum. - + doi:10.1016/j.cub.2021.10.015 D2-matrix - + doi:10.1016/j.cub.2021.10.015 D2M - + doi:10.1016/j.cub.2021.10.015 matrix D2-MSN - + doi:10.1016/j.cub.2021.10.015 In Rhesus macaques, both matrix D1 and D2 medium spiny neuron cell types have been noted to have enriched gene expression of the following: EPHA4, GDA, STXBP6, and SEMA3E. Broadly understood, matrix MSNs receive neocortical inputs from the associative and sensorimotor cortex and give rise to the direct and indirect pathways. - + doi:10.1016/j.cub.2021.10.015 @@ -95310,13 +95573,13 @@ Midget bipolar cells (imb, fmb) have larger axon terminals at greater distances A DRD1-expressing medium spiny neuron that is part of a striosome of dorsal striatum. - + doi:10.1016/j.cub.2021.10.015 striosome D1 medium spiny neuron - + doi:10.1016/j.cub.2021.10.015 @@ -95329,21 +95592,21 @@ Midget bipolar cells (imb, fmb) have larger axon terminals at greater distances D1S - + doi:10.1016/j.cub.2021.10.015 striosome D1-MSN - + doi:10.1016/j.cub.2021.10.015 In Rhesus macaques, both striosomal D1 and D2 medium spiny neuron (MSN) cell types have been noted to have enriched gene expression of the following: KCNT1, KHDRBS3, FAM163A, BACH2, and KCNIP1. Striosomal MSN activations have been noted to influence cognitive and emotional decision making and value-based learning. In contrast to matrix MSNs, striosomal MSNs receive input from limbic territories, including the anterior cingulate cortex, orbitofrontal cortex, and anterior insular cortex, and project directly to midbrain dopamine neurons. - + doi:10.1016/j.cub.2021.10.015 @@ -95381,40 +95644,40 @@ Midget bipolar cells (imb, fmb) have larger axon terminals at greater distances A DRD2-expressing medium spiny neuron that is part of a striosome of dorsal striatum. - + doi:10.1016/j.cub.2021.10.015 striosome D2 medium spiny neuron - + doi:10.1016/j.cub.2021.10.015 D2-striosome - + doi:10.1016/j.cub.2021.10.015 D2S - + doi:10.1016/j.cub.2021.10.015 striosome D2-MSN - + doi:10.1016/j.cub.2021.10.015 In Rhesus macaques, both striosomal D1 and D2 medium spiny neuron (MSN) cell types have been noted to have enriched gene expression of the following: KCNT1, KHDRBS3, FAM163A, BACH2, and KCNIP1. Striosomal MSN activations have been noted to influence cognitive and emotional decision making and value-based learning. In contrast to matrix MSNs, striosomal MSNs receive input from limbic territories, including the anterior cingulate cortex, orbitofrontal cortex, and anterior insular cortex, and project directly to midbrain dopamine neurons. - + doi:10.1016/j.cub.2021.10.015 @@ -95454,41 +95717,41 @@ Midget bipolar cells (imb, fmb) have larger axon terminals at greater distances A medium spiny neuron that expresses both DRD1 and DRD2 and is part of an extra-striosomal part of dorsal striatum. - + doi:10.1016/j.cub.2021.10.015 D1/2 - + doi:10.1016/j.cub.2021.10.015 D1/D2 hybrid - + doi:10.1016/j.cub.2021.10.015 D1/D2-hybrid MSN - + doi:10.1016/j.cub.2021.10.015 hybrid D1/2 cell type - + doi:10.1016/j.cub.2021.10.015 It has been noted in non-human primate species that the D1/D2-hybrid medium spiny neuron (D1/2) cell type shows the same amount of DRD1 expression as nearby D1 medium spiny neurons but far less DRD2 expression compared to nearby D2 medium spiny neurons. In Rhesus macaques, RXFP1 has been noted as a highly specific marker gene for the D1/2 cell type. The D1/2 cell type has also been described as having characteristics similar to a novel medium spiny neuron described in rodents (D1H or eccentric spiny projection neuron). Although an extrastriosomal cell type, the D1/2 cell type had been noted to express many of the genes associated with striosome, suggesting a possible homology to ‘‘exo-patch’’ cells. - + doi:10.1016/j.cub.2021.10.015 @@ -97585,6 +97848,98 @@ Midget bipolar cells (imb, fmb) have larger axon terminals at greater distances + + + + + + + + + + + + A midget ganglion cell that depolarizes in response to increased light intensity in the center of its receptive field. The majority of input that this cell receives comes from invaginating midget bipolar cells. + + 2023-08-08T09:40:08Z + ON-midget RGC + ON-midget cell + inner stratifying midget cell + ON midget ganglion cell + + + + + A midget ganglion cell that depolarizes in response to increased light intensity in the center of its receptive field. The majority of input that this cell receives comes from invaginating midget bipolar cells. + PMID:32032773 + + + + + ON-midget RGC + PMID:34093409 + + + + + ON-midget cell + PMID:34093409 + + + + + inner stratifying midget cell + PMID:32032773 + + + + + + + + + + + + + + + + A midget ganglion cell that depolarizes in response to decreased light intensity in the center of its receptive field. The majority of input that this cell receives comes from flat midget bipolar cells. + + 2023-08-08T11:05:37Z + OFF-midget RGC + OFF-midget cell + outer stratifying midget cell + OFF midget ganglion cell + + + + + A midget ganglion cell that depolarizes in response to decreased light intensity in the center of its receptive field. The majority of input that this cell receives comes from flat midget bipolar cells. + PMID:32032773 + + + + + OFF-midget RGC + PMID:34093409 + + + + + OFF-midget cell + PMID:34093409 + + + + + outer stratifying midget cell + PMID:32032773 + + + + @@ -97716,6 +98071,188 @@ Midget bipolar cells (imb, fmb) have larger axon terminals at greater distances + + + + + + + + + + + + A parasol ganglion cell that depolarizes in response to decreased light intensity in the center of its receptive field. The majority of input that this cell receives comes from DB3a bipolar cells. + + 2023-08-08T12:34:57Z + OFF-parasol RGC + OFF-parasol retinal ganglion cell + outer parasol cell + OFF parasol ganglion cell + + + + + A parasol ganglion cell that depolarizes in response to decreased light intensity in the center of its receptive field. The majority of input that this cell receives comes from DB3a bipolar cells. + PMID:32032773 + + + + + OFF-parasol RGC + PMID:34093409 + + + + + OFF-parasol retinal ganglion cell + PMID:34093409 + + + + + outer parasol cell + PMID:32032773 + + + + + + + + + + + + + + + + A parasol ganglion cell that depolarizes in response to increased light intensity in the center of its receptive field. The majority of input that this cell receives comes from DB4 bipolar cells. + + 2023-08-08T12:39:35Z + ON-parasol RGC + ON-parasol retinal ganglion cell + inner parasol cell + ON parasol ganglion cell + + + + + A parasol ganglion cell that depolarizes in response to increased light intensity in the center of its receptive field. The majority of input that this cell receives comes from DB4 bipolar cells. + PMID:32032773 + + + + + ON-parasol RGC + PMID:34093409 + + + + + ON-parasol retinal ganglion cell + PMID:34093409 + + + + + inner parasol cell + PMID:32032773 + + + + + + + + + + + + + + + A bistratfied retinal ganglion cell with a small dendritic field that has dendrites in the ON and OFF sublamina of the retinal inner plexiform layer and carries blue-ON/yellow-OFF signals. This cell receives bipolar and amacrine input to both the OFF and ON dendritic tree. + + 2023-08-08T12:43:56Z + small bistratified cell + small bistratified cell, blue-ON/yellow-OFF ganglion cell + Polyak's shrub cell + SBS ganglion cell + sbRGC + small bistratified retinal ganglion cell + + + + + A bistratfied retinal ganglion cell with a small dendritic field that has dendrites in the ON and OFF sublamina of the retinal inner plexiform layer and carries blue-ON/yellow-OFF signals. This cell receives bipolar and amacrine input to both the OFF and ON dendritic tree. + PMID:32032773 + + + + + small bistratified cell + PMID:32032773 + + + + + small bistratified cell, blue-ON/yellow-OFF ganglion cell + doi:10.1002/cne.22183 + + + + + Polyak's shrub cell + PMID:32032773 + + + + + SBS ganglion cell + PMID:32032773 + + + + + + sbRGC + PMID:34093409 + + + + + + + + + + + + + + + + + + + + A cell that is adjacent to a vessel. A perivascular cell plays a crucial role in maintaining vascular function and tissue homeostasis. This cell type regulates vessel integrity and flow dynamics. + + 2023-08-22T13:40:28Z + perivascular cell + + + + + A cell that is adjacent to a vessel. A perivascular cell plays a crucial role in maintaining vascular function and tissue homeostasis. This cell type regulates vessel integrity and flow dynamics. + PMID:24928499 + PMID:27889329 + + + + @@ -98443,6 +98980,12 @@ Midget bipolar cells (imb, fmb) have larger axon terminals at greater distances + + + + + + @@ -98725,6 +99268,12 @@ Midget bipolar cells (imb, fmb) have larger axon terminals at greater distances + + + + + + @@ -99535,6 +100084,12 @@ Midget bipolar cells (imb, fmb) have larger axon terminals at greater distances + + + + + + @@ -102877,6 +103432,12 @@ Midget bipolar cells (imb, fmb) have larger axon terminals at greater distances + + + + + + @@ -104671,6 +105232,12 @@ Midget bipolar cells (imb, fmb) have larger axon terminals at greater distances + + + + + + @@ -105745,14 +106312,14 @@ Midget bipolar cells (imb, fmb) have larger axon terminals at greater distances - + - + - + diff --git a/cl.obo b/cl.obo index 9ef47859d..161458495 100644 --- a/cl.obo +++ b/cl.obo @@ -1,5 +1,5 @@ format-version: 1.2 -data-version: releases/2023-07-20 +data-version: releases/2023-08-24 subsetdef: abnormal_slim "" subsetdef: added_for_HCA "" subsetdef: attribute_slim "" @@ -109,7 +109,7 @@ property_value: dc-description "An ontology of cell types." xsd:string property_value: dc-title "Cell Ontology" xsd:string property_value: dcterms-license http://creativecommons.org/licenses/by/4.0/ property_value: has_ontology_root_term CL:0000000 -property_value: owl:versionInfo "2023-07-20" xsd:string +property_value: owl:versionInfo "2023-08-24" xsd:string [Term] id: BFO:0000002 @@ -902,6 +902,7 @@ is_a: CL:0000548 ! animal cell is_a: CL:0000675 {is_inferred="true"} ! female gamete relationship: develops_from CL:0000023 ! oocyte relationship: participates_in GO:0007143 ! female meiotic nuclear division +property_value: depicted_by "https://www.swissbiopics.org/api/image/Egg_cell.svg" xsd:anyURI [Term] id: CL:0000026 @@ -1023,7 +1024,7 @@ subset: human_reference_atlas synonym: "blood forming stem cell" EXACT [] synonym: "colony forming unit hematopoietic" RELATED [] synonym: "hemopoietic stem cell" EXACT [] -synonym: "HSC" EXACT [] +synonym: "HSC" RELATED abbreviation [] xref: BTO:0000725 xref: CALOHA:TS-0448 xref: FMA:70337 @@ -1069,10 +1070,10 @@ id: CL:0000038 name: erythroid progenitor cell def: "A progenitor cell committed to the erythroid lineage." [GOC:add, ISBN:0721601464] subset: blood_and_immune_upper_slim -synonym: "BFU-E" RELATED [] +synonym: "BFU-E" RELATED abbreviation [] synonym: "blast forming unit erythroid" RELATED [] synonym: "burst forming unit erythroid" RELATED [] -synonym: "CFU-E" RELATED [] +synonym: "CFU-E" RELATED abbreviation [] synonym: "colony forming unit erythroid" RELATED [] synonym: "erythroid stem cell" RELATED [] xref: BTO:0004911 @@ -1096,7 +1097,7 @@ id: CL:0000040 name: monoblast def: "A myeloid progenitor cell committed to the monocyte lineage. This cell is CD11b-positive, has basophilic cytoplasm, euchromatin, and the presence of a nucleolus." [GOC:add, http://en.wikipedia.org/wiki/Monoblast, http://www.copewithcytokines.de, PMID:1104740] comment: Morphology: mononuclear cell, diameter 12-20 _M, non-granular, N/C ratio 3/1 - 4/1; markers: CD11b (shared with many other myeloid cells); location: Adult: bone marrow; fetal: liver, Yolk Sac; role or process: hematopoiesis, monocyte development; lineage: hematopoietic, myeloid. -synonym: "CFU-M" RELATED [] +synonym: "CFU-M" RELATED abbreviation [] synonym: "colony forming unit macrophage" RELATED [] synonym: "colony forming unit monocyte" RELATED [] synonym: "monocyte stem cell" RELATED [] @@ -1236,9 +1237,9 @@ name: common myeloid progenitor def: "A progenitor cell committed to myeloid lineage, including the megakaryocyte and erythroid lineages." [GOC:add, ISBN:0878932437, MESH:D023461] comment: This cell type is intended to be compatible with any vertebrate common myeloid progenitor. For mammalian CMP known to be CD34-positive, please use the term 'common myeloid progenitor, CD34-positive' (CL_0001059). subset: human_reference_atlas -synonym: "CFU-GEMM" RELATED [ISBN:0878932437] -synonym: "CFU-S" RELATED [ISBN:0878932437] -synonym: "CMP" EXACT [ISBN:0878932437] +synonym: "CFU-GEMM" RELATED abbreviation [ISBN:0878932437] +synonym: "CFU-S" RELATED abbreviation [ISBN:0878932437] +synonym: "CMP" RELATED abbreviation [ISBN:0878932437] synonym: "colony forming unit granulocyte, erythrocyte, macrophage, and megakaryocyte" RELATED [ISBN:0878932437] synonym: "common myeloid precursor" EXACT [] synonym: "multipotential myeloid stem cell" RELATED [ISBN:0878932437] @@ -1283,13 +1284,13 @@ alt_id: CL:0000044 def: "A oligopotent progenitor cell committed to the lymphoid lineage." [GOC:add, GOC:dsd, GOC:tfm, PMID:10407577, PMID:16551251] comment: CLP are CD7-positive, CD10-positive, CD19-negative, CD34-positive, CD45RA-positive, CD79a-negative, CD127-positive, AA4.1-positive, RAG-negative, Sca-1-low, sIgM-negative, sIgD-negative, TdT-negative, Vpre-B-negative, and pre-BCR-negative. Expression of transcription factors include E2A-positive, EBF-positive, Ikaros-negative, PU.1-negative, and Pax5-negative. subset: human_reference_atlas -synonym: "CLP" EXACT [] +synonym: "CLP" RELATED abbreviation [] synonym: "committed lymphopoietic stem cell" RELATED [] synonym: "common lymphocyte precursor" EXACT [] synonym: "common lymphocyte progenitor" EXACT [] synonym: "common lymphoid precursor" EXACT [] synonym: "early lymphocyte progenitor" RELATED [] -synonym: "ELP" RELATED [] +synonym: "ELP" RELATED abbreviation [] synonym: "lymphoid stem cell" RELATED [] synonym: "lymphopoietic stem cell" RELATED [] is_a: CL:0002032 {is_inferred="true"} ! hematopoietic oligopotent progenitor cell @@ -1479,6 +1480,7 @@ is_a: CL:0000548 ! animal cell disjoint_from: CL:0000738 ! leukocyte relationship: part_of UBERON:0000483 ! epithelium relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens +property_value: depicted_by "https://www.swissbiopics.org/api/image/Epithelial_cells.svg" xsd:anyURI [Term] id: CL:0000067 @@ -2260,7 +2262,7 @@ relationship: develops_from CL:0000223 ! endodermal cell [Term] id: CL:0000132 name: corneal endothelial cell -def: "An hexagonal, flattened, mitochondria-rich endothelial cell that forms a monolayer on the posterior surface of the cornea (the corneal endothelium). Corneal endothelial cells are derived from the neural crest and are responsible for keeping the cornea transparent by maintaining the tissue in a semi-dry state through the action of their ionic pumps and tight junction barrier." [GOC:tfm, MESH:A09.371.060.067.31, PMID:21976958, PMID:23284695, PMID:34741068, PMID:36769303] +def: "An hexagonal, flattened, mitochondria-rich endothelial cell that forms a monolayer on the posterior surface of the cornea (the corneal endothelium). Corneal endothelial cells are derived from the neural crest and are responsible for keeping the cornea transparent by maintaining the tissue in a semi-dry state through the action of their ionic pumps and tight junction barrier." [GOC:tfm, PMID:21976958, PMID:23284695, PMID:34741068, PMID:36769303] subset: eye_upper_slim subset: human_reference_atlas xref: CALOHA:TS-0172 @@ -2284,9 +2286,9 @@ name: mesenchymal stem cell alt_id: CL:0002452 def: "A connective tissue cell that normally gives rise to other cells that are organized as three-dimensional masses. In humans, this cell type is CD73-positive, CD90-positive, CD105-positive, CD45-negative, CD34-negative, and MHCII-negative. They may further differentiate into osteoblasts, adipocytes, myocytes, neurons, or chondroblasts in vitro. Originally described as residing in the bone marrow, this cell type is now known to reside in many, if not all, adult organs." [FB:ma, GOC:dsd, http://en.wikipedia.org/wiki/Mesenchymal_stem_cell, http://www.copewithcytokines.de/cope.cgi?key=mesenchymal%20stem%20cells, PMCID:PMC2613570, PMID:10102814, PMID:16923606, PMID:17986482, PMID:19960544] comment: Many but not all mesenchymal cells derive from the mesoderm. MSCs are reportedly CD3-negative, CD4-negative, CD5-negative, CD8-negative, CD11a-negative, CD11b-negative, CD14-negative, CD19-negative, CD29-positive, CD31-negative, CD34-negative, CD38-negative, CD40-negative, CD44-positive, CD45-negative, CD49-positive, CD54-positive, CD66b-negative, CD79a-negative, CD80-negative, CD102-positive, CD106-positive, CD117-positive, CD121a-positive, CD121b-positive, CD123-positive, CD124-positive, CD133-negative, CD146-positive, CD166-positive, CD271-positive, B220-negative, Gr1-negative, MHCI-positive, MHCII-negative, SSEA4-negative, sca1-positive, Ter119-negative, and glycophorin A-negative. Cultured MSCs are capable of producing stem cell factor, IL7, IL8, IL11, TGF-beta, cofilin, galectin-1, laminin-receptor 1, cyclophilin A, and MMP-2. -synonym: "BMSC" NARROW [] +synonym: "BMSC" RELATED abbreviation [] synonym: "bone marrow stromal cells" NARROW [] -synonym: "CFU-F" RELATED [] +synonym: "CFU-F" RELATED abbreviation [] synonym: "colony-forming unit-fibroblast" NARROW [] synonym: "marrow stromal cells" NARROW [PMID:11378515] synonym: "mesenchymal precursor cell" RELATED [] @@ -2294,7 +2296,7 @@ synonym: "mesenchymal progenitor cells" RELATED PLURAL [MESH:D044982] synonym: "mesenchymal stem cell" RELATED [] synonym: "mesenchymal stromal cell" RELATED [] synonym: "mesenchymal stromal cells" RELATED PLURAL [] -synonym: "MSC" RELATED [PMID:11378515] +synonym: "MSC" RELATED abbreviation [PMID:11378515] synonym: "stem cells, mesenchymal" RELATED PLURAL [MESH:D044982] xref: BTO:0002625 xref: BTO:0003298 @@ -2410,7 +2412,7 @@ name: professional antigen presenting cell def: "A cell capable of processing and presenting lipid and protein antigens to T cells in order to initiate an immune response." [GOC:add, ISBN:0781735149] comment: Note change of name; nearly all somatic cells can present antigens to T cells via MHC Class I complexes leading to effector responses, but professional antigen presenting cells constitutively express MHC Class II as well as costimulatory molecules, and thus can initiate immune responses via T cells. subset: blood_and_immune_upper_slim -synonym: "APC" BROAD [] +synonym: "APC" RELATED abbreviation [] is_a: CL:0000738 ! leukocyte intersection_of: CL:0000738 ! leukocyte intersection_of: capable_of GO:0002504 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II @@ -2574,11 +2576,10 @@ is_a: CL:0000319 ! mucus secreting cell [Term] id: CL:0000161 -name: acid secreting cell -is_a: CL:0000151 {is_inferred="true"} ! secretory cell -intersection_of: CL:0000151 ! secretory cell -intersection_of: capable_of GO:0046717 ! acid secretion -relationship: capable_of GO:0046717 ! acid secretion +name: obsolete acid secreting cell +comment: https://github.com/obophenotype/cell-ontology/issues/427 +is_obsolete: true +consider: CL:0000162 [Term] id: CL:0000162 @@ -2587,8 +2588,8 @@ def: "A large, oval stomach epithelial cell with a central nucleus; source of ga synonym: "oxyntic cell" EXACT [] xref: BTO:0001780 xref: FMA:62901 -is_a: CL:0000161 ! acid secreting cell is_a: CL:0002659 ! glandular cell of stomach +relationship: capable_of GO:0046717 ! acid secretion [Term] id: CL:0000163 @@ -2894,6 +2895,7 @@ is_a: CL:0000183 ! contractile cell is_a: CL:0000393 ! electrically responsive cell is_a: CL:0002371 ! somatic cell relationship: develops_from CL:0000056 ! myoblast +property_value: depicted_by "https://www.swissbiopics.org/api/image/Muscle_cells.svg" xsd:anyURI [Term] id: CL:0000188 @@ -2993,8 +2995,8 @@ id: CL:0000198 name: pain receptor cell def: "The peripheral receptor for pain. Includes receptors which are sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli. All mammalian nociceptors are free nerve endings." [MESH:D009619] comment: Editor note: request detection of stimulus involved in sensory perception of pain; add develops_from relationship -synonym: "nociceptor" EXACT [] -synonym: "nocireceptor" EXACT [] +synonym: "nociceptor" EXACT [] {http://www.w3.org/2000/01/rdf-schema#seeAlso="https://meshb.nlm.nih.gov/record/ui?ui=D009619"} +synonym: "nocireceptor" EXACT [] {http://www.w3.org/2000/01/rdf-schema#seeAlso="https://www.thefreedictionary.com/nocireceptor"} is_a: CL:0000006 ! neuronal receptor cell [Term] @@ -3107,6 +3109,7 @@ is_a: CL:0000006 {is_inferred="true"} ! neuronal receptor cell intersection_of: CL:0000540 ! neuron intersection_of: capable_of GO:0050962 ! detection of light stimulus involved in sensory perception relationship: capable_of GO:0050962 ! detection of light stimulus involved in sensory perception +property_value: depicted_by "https://www.swissbiopics.org/api/image/Photoreceptor_cell.svg" xsd:anyURI [Term] id: CL:0000211 @@ -4113,7 +4116,7 @@ replaced_by: PO:0020090 [Term] id: CL:0000333 name: migratory neural crest cell -def: "A cell derived from the specialized ectoderm flanking each side of the embryonic neural plate, which after the closure of the neural tube, forms masses of cells that migrate out from the dorsal aspect of the neural tube to spread throughout the body." [MESH:A16.254.600] +def: "A cell derived from the specialized ectoderm flanking each side of the embryonic neural plate, which after the closure of the neural tube, forms masses of cells that migrate out from the dorsal aspect of the neural tube to spread throughout the body." [doi:10.1016/j.stem.2015.02.017] xref: FMA:86667 is_a: CL:0000219 ! motile cell is_a: CL:0011012 ! neural crest cell @@ -4337,6 +4340,7 @@ subset: human_reference_atlas synonym: "vascular smooth muscle cell" EXACT [] synonym: "VSMC" EXACT [] is_a: CL:0000192 {is_inferred="true"} ! smooth muscle cell +is_a: CL:4033054 ! perivascular cell intersection_of: CL:0000192 ! smooth muscle cell intersection_of: part_of UBERON:0002049 ! vasculature relationship: part_of UBERON:0002049 ! vasculature @@ -5726,15 +5730,17 @@ id: CL:0000525 name: syncytiotrophoblast cell def: "A cell from the outer syncytial layer of the trophoblast of an early mammalian embryo, directly associated with the maternal blood supply. It secretes hCG in order to maintain progesterone secretion and sustain a pregnancy." [GOC:tfm, ISBN:0323052908] subset: human_reference_atlas -synonym: "plasmidotrophoblast" EXACT [] -synonym: "syncytial trophoblast" EXACT [] -synonym: "syntrophoblast" EXACT [] +synonym: "plasmidotrophoblast cell" RELATED [] +synonym: "syncytial trophoblast cell" EXACT [PMID:11787150] +synonym: "syncytiotrophoblastic cell" EXACT [PMID:21733368] +synonym: "syntrophoblast cell" RELATED [] xref: FMA:83043 is_a: CL:0000228 ! multinucleate cell is_a: CL:2000060 ! placental villous trophoblast intersection_of: CL:0000351 ! trophoblast cell intersection_of: bearer_of PATO:0001908 ! multinucleate relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens +property_value: seeAlso "https://github.com/obophenotype/cell-ontology/issues/2100" xsd:string [Term] id: CL:0000526 @@ -5856,6 +5862,7 @@ is_a: CL:0002319 ! neural cell relationship: capable_of GO:0019226 ! transmission of nerve impulse relationship: develops_from CL:0000031 {gci_relation="in_taxon", gci_filler="NCBITaxon:7742", xref="https://github.com/obophenotype/cell-ontology/issues/757"} ! neuroblast (sensu Vertebrata) relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens +property_value: depicted_by "https://www.swissbiopics.org/api/image/Neuron_cells.svg" xsd:anyURI [Term] id: CL:0000541 @@ -5967,7 +5974,7 @@ relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: CL:0000547 name: proerythroblast -def: "An immature, nucleated erythrocyte occupying the stage of erythropoeisis that follows formation of erythroid progenitor cells. This cell is CD71-positive, has both a nucleus and a nucleolus, and lacks hematopoeitic lineage markers." [ISBN:0721601464, MESH:A11.118.290.350.200, PMID:1638021] +def: "An immature, nucleated erythrocyte occupying the stage of erythropoeisis that follows formation of erythroid progenitor cells. This cell is CD71-positive, has both a nucleus and a nucleolus, and lacks hematopoeitic lineage markers." [ISBN:0721601464, PMID:1638021] subset: blood_and_immune_upper_slim synonym: "pronormoblast" RELATED [] synonym: "rubriblast" EXACT [ISBN:0721601464] @@ -6019,6 +6026,7 @@ is_a: CL:0000255 ! eukaryotic cell intersection_of: CL:0000003 ! native cell intersection_of: only_in_taxon NCBITaxon:33208 ! Metazoa relationship: only_in_taxon NCBITaxon:33208 ! Metazoa +property_value: depicted_by "https://www.swissbiopics.org/api/image/Animal_cells.svg" xsd:anyURI [Term] id: CL:0000549 @@ -6175,9 +6183,9 @@ def: "A hematopoietic progenitor cell that is committed to the granulocyte and m comment: Originally described in the dendritic cell ontology (DC_CL:0000042)(PMID:19243617). GMPs are reportedly CD16-positive, CD32-positive, CD34-positive, CD38-positive, CD45RA-positive, CD110-negative, CD117-positive, CD123-positive, and SCA1-negative. subset: human_reference_atlas synonym: "CFU-C , Colony forming unit in culture" BROAD [http://www.copewithcytokines.de] -synonym: "CFU-GM" EXACT [ISBN:0721601464, PMCID:PMC2213186, PMCID:PMC548021] +synonym: "CFU-GM" RELATED abbreviation [ISBN:0721601464, PMCID:PMC2213186, PMCID:PMC548021] synonym: "colony forming unit granulocyte macrophage" EXACT [ISBN:0721601464, PMCID:PMC2213186, PMCID:PMC548021] -synonym: "GMP" EXACT [ISBN:0721601464, PMCID:PMC2213186, PMCID:PMC548021] +synonym: "GMP" RELATED abbreviation [ISBN:0721601464, PMCID:PMC2213186, PMCID:PMC548021] synonym: "granulocyte-macrophage progenitor" EXACT [ISBN:0721601464, PMCID:PMC2213186, PMCID:PMC548021] synonym: "granulocyte/monocyte precursor" EXACT [] synonym: "granulocyte/monocyte progenitor" EXACT [] @@ -6396,10 +6404,11 @@ is_a: CL:0000198 ! pain receptor cell [Term] id: CL:0000568 name: amine precursor uptake and decarboxylation cell -def: "A cell that originates in the neural crest, that has certain cytochemical and ultrastructural characteristics and is found scattered throughout the body; types include melanocytes, the cells of the chromaffin system, and cells in the hypothalamus, hypophysis, thyroid, parathyroids, lungs, gastrointestinal tract, and pancreas. This cell type concentrates the amino acid precursors of certain amines and decarboxylate them, forming amines that function as regulators and neurotransmitters. This cell type produces substances such as epinephrine, norepinephrine, dopamine, serotonin, enkephalin, somatostatin, neurotensin, and substance P, the actions of which may affect contiguous cells, nearby groups of cells, or distant cells, thus functioning as local or systemic hormones. The name is an acronym for amine precursor uptake and decarboxylation cell." [GOC:tfm, ISBN:0721662544, MESH:A11.070] +def: "A cell that originates in the neural crest, that has certain cytochemical and ultrastructural characteristics and is found scattered throughout the body; types include melanocytes, the cells of the chromaffin system, and cells in the hypothalamus, hypophysis, thyroid, parathyroids, lungs, gastrointestinal tract, and pancreas. This cell type concentrates the amino acid precursors of certain amines and decarboxylate them, forming amines that function as regulators and neurotransmitters. This cell type produces substances such as epinephrine, norepinephrine, dopamine, serotonin, enkephalin, somatostatin, neurotensin, and substance P, the actions of which may affect contiguous cells, nearby groups of cells, or distant cells, thus functioning as local or systemic hormones. The name is an acronym for amine precursor uptake and decarboxylation cell." [GOC:tfm, ISBN:0721662544] synonym: "APUD cell" EXACT [] xref: BTO:0003866 xref: FMA:83114 +xref: MESH:D001078 is_a: CL:0000165 ! neuroendocrine cell [Term] @@ -6513,13 +6522,14 @@ relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens id: CL:0000577 name: type EC enteroendocrine cell alt_id: CL:0002065 -def: "A subtype of enteroendocrine cells found in the gastrointestinal mucosa, particularly in the glands of pyloric antrum; duodenum; and ileum. These cell type secretes serotonin and some neurotransmitters including enkephalins and substance P. Their secretory granules stain readily with silver (argentaffin stain)." [MESH:A03.492.766.440.250, PMID:9505449] +def: "A subtype of enteroendocrine cells found in the gastrointestinal mucosa, particularly in the glands of pyloric antrum; duodenum; and ileum. These cell type secretes serotonin and some neurotransmitters including enkephalins and substance P. Their secretory granules stain readily with silver (argentaffin stain)." [PMID:9505449] subset: human_reference_atlas synonym: "argentaffin cell" EXACT [] synonym: "enterochromaffin cell" EXACT [] synonym: "Kulchitsky cell" EXACT [] xref: FMA:62934 xref: FMA:83132 +xref: MESH:D004759 is_a: CL:0000164 ! enteroendocrine cell is_a: CL:0000166 ! chromaffin cell is_a: CL:0000458 ! serotonin secreting cell @@ -6737,7 +6747,7 @@ is_a: CL:0000205 ! thermoreceptor cell [Term] id: CL:0000588 name: odontoclast -def: "A specialized osteoclast associated with the absorption and removal of cementum." [GOC:add, MESH:A11.329.679] +def: "A specialized osteoclast associated with the absorption and removal of cementum." [GOC:add] xref: BTO:0002516 xref: FMA:83027 is_a: CL:0000092 {is_inferred="true"} ! osteoclast @@ -6803,7 +6813,7 @@ is_a: CL:0000680 ! muscle precursor cell id: CL:0000595 name: enucleate erythrocyte def: "An erythrocyte lacking a nucleus." [GOC:add, GOC:tfm] -synonym: "RBC" BROAD [] +synonym: "RBC" RELATED abbreviation [] synonym: "red blood cell" BROAD [] is_a: CL:0000225 ! anucleate cell is_a: CL:0000232 {is_inferred="true"} ! erythrocyte @@ -6940,9 +6950,9 @@ consider: PO:0009002 id: CL:0000611 name: eosinophil progenitor cell comment: These cells are CD34-positive, CD45RA-negative, CD71-negative, and lineage-negative (CD2, CD3 epsilon, CD4, CD5, CD8a, CD14, CD19, CD20, integrin alpha-M, NCAM-1, SCA-1, Ly6G, Ly76). -synonym: "CFU-Eo" RELATED [] +synonym: "CFU-Eo" RELATED abbreviation [] synonym: "colony forming unit eosinophil" RELATED [] -synonym: "EoP" EXACT [PMCID:PMC2212039, PMCID:PMC2626675] +synonym: "EoP" RELATED abbreviation [PMCID:PMC2212039, PMCID:PMC2626675] synonym: "eosinophil stem cell" RELATED [] is_a: CL:0000763 ! myeloid cell is_a: CL:0002191 {is_inferred="true"} ! granulocytopoietic cell @@ -7121,7 +7131,7 @@ xref: FBbt:00007228 xref: FMA:84788 xref: MESH:D059330 xref: WBbt:0005190 -is_a: CL:0000161 ! acid secreting cell +is_a: CL:0000151 ! secretory cell is_a: CL:0000540 ! neuron intersection_of: CL:0000540 ! neuron intersection_of: capable_of GO:0061534 ! gamma-aminobutyric acid secretion, neurotransmission @@ -7230,12 +7240,20 @@ relationship: RO:0002104 PR:000025402 ! has plasma membrane part T cell receptor [Term] id: CL:0000626 name: olfactory granule cell -def: "Granule cell that is part of the olfactory bulb." [GOC:mah] +def: "A granule cell that has a soma located in an olfactory bulb granule cell layer. An olfactory granule cell is an interneuron that lacks an axon, makes reciprocal dendro-dendritic synapses with mitral cells and tufted cells and is involved in the fine spatio-temporal tuning of the responses of these principal olfactory bulb neurons to odors." [doi:10.1038/s41598-018-27692-8, GOC:mah] +comment: Granule cells are the most abundant neuronal population in the olfactory bulb and are continuously renewed throughout life. {xref="doi:10.1038/s41598-018-27692-8"} +synonym: "olfactory bulb granule cell" EXACT [doi:10.1038/s41598-018-27692-8] is_a: CL:0000120 ! granule cell is_a: CL:0012001 ! neuron of the forebrain +is_a: CL:1001434 ! olfactory bulb interneuron intersection_of: CL:0000120 ! granule cell -intersection_of: RO:0002100 UBERON:0002264 ! has soma location olfactory bulb -relationship: RO:0002100 UBERON:0002264 ! has soma location olfactory bulb +intersection_of: RO:0002100 UBERON:0005378 ! has soma location olfactory bulb granule cell layer +relationship: RO:0002100 UBERON:0005378 ! has soma location olfactory bulb granule cell layer +relationship: RO:0002120 CL:1001502 ! synapsed to mitral cell +relationship: RO:0002120 CL:1001503 ! synapsed to olfactory bulb tufted cell +relationship: RO:0002428 GO:0007608 ! involved in regulation of sensory perception of smell +relationship: synapsed_by CL:1001502 ! mitral cell +relationship: synapsed_by CL:1001503 ! olfactory bulb tufted cell [Term] id: CL:0000627 @@ -8016,14 +8034,16 @@ id: CL:0000706 name: choroid plexus epithelial cell alt_id: CL:1000430 def: "Specialized ependymal cell that produces the cerebrospinal fluid from the blood and secretes it into the lumen of the brain and spinal chord." [GOC:add, GOC:tfm, JB:jb, PMID:9550134] +synonym: "choroid plexus cell" BROAD [DOI:10.1101/2022.10.12.511898] synonym: "epithelial cell of choroid plexus" EXACT [] xref: FMA:70549 is_a: CL:0000065 ! ependymal cell is_a: CL:0000627 ! transporting cell is_a: CL:0002319 ! neural cell -is_a: CL:4023073 ! choroid plexus cell intersection_of: CL:0000065 ! ependymal cell intersection_of: part_of UBERON:0001886 ! choroid plexus +relationship: part_of UBERON:0001886 ! choroid plexus +property_value: dcterms-date "2023-08-04T08:48:30Z" xsd:dateTime [Term] id: CL:0000707 @@ -8039,7 +8059,6 @@ def: "Stromal cell that forms the internal covering of the vertebrate brain and synonym: "leptomemingeal cell" RELATED [] is_a: CL:0000327 {is_inferred="true"} ! extracellular matrix secreting cell is_a: CL:0002319 ! neural cell -is_a: CL:4023073 ! choroid plexus cell intersection_of: CL:0000327 ! extracellular matrix secreting cell intersection_of: part_of UBERON:0003210 ! blood-cerebrospinal fluid barrier relationship: part_of UBERON:0003210 ! blood-cerebrospinal fluid barrier @@ -9216,7 +9235,7 @@ synonym: "gamma-delta T lymphocyte" EXACT [] synonym: "gamma-delta T-cell" EXACT [] synonym: "gamma-delta T-lymphocyte" EXACT [] synonym: "gammadelta T cell" EXACT [] -synonym: "gd T cell" RELATED [] +synonym: "gd T cell" RELATED abbreviation [] is_a: CL:0000084 {is_inferred="true"} ! T cell intersection_of: CL:0000084 ! T cell intersection_of: RO:0002104 GO:0042106 ! has plasma membrane part gamma-delta T cell receptor complex @@ -10649,6 +10668,7 @@ name: perivascular macrophage def: "A central nervous system macrophage found in small blood vessels in the brain. Markers include CD14+CD16+CD163+." [GO_REF:0000031, GOC:tfm, PMID:16507898] comment: Markers: Human/monkey, mice: CD163. Human: CD14+CD16+CD163+. is_a: CL:0000878 {is_inferred="true"} ! central nervous system macrophage +is_a: CL:4033054 ! perivascular cell is_a: PR:000050567 ! protein-containing material entity intersection_of: CL:0000878 ! central nervous system macrophage intersection_of: part_of UBERON:0001981 ! blood vessel @@ -11641,9 +11661,9 @@ id: CL:0000936 name: early lymphoid progenitor def: "A lymphoid progenitor cell that is found in bone marrow, gives rise to B cells, T cells, natural killer cells and dendritic cells, and has the phenotype Lin-negative, Kit-positive, Sca-1-positive, FLT3-positive, CD34-positive, CD150 negative, and GlyA-negative." [GO_REF:0000031, GOC:add, GOC:dsd, GOC:pam, GOC:tfm, PMID:19022770] comment: Markers are associated with mouse cells. ELP transcription factors include E2A-positive, Ikaros-positive, EBF-negative, Pax5-negative, PU.1-negative. -synonym: "ELP" EXACT [] -synonym: "GMLP" RELATED [PMID:18371378] -synonym: "LMPP" EXACT [] +synonym: "ELP" RELATED abbreviation [] +synonym: "GMLP" RELATED abbreviation [PMID:18371378] +synonym: "LMPP" RELATED abbreviation [] synonym: "lymphoid-primed multipotent progenitor" EXACT [] is_a: CL:0000837 {is_inferred="true"} ! hematopoietic multipotent progenitor cell is_a: CL:0011026 ! progenitor cell @@ -13589,9 +13609,9 @@ id: CL:0001059 name: common myeloid progenitor, CD34-positive def: "A progenitor cell committed to myeloid lineage, including the megakaryocyte and erythroid lineages. These cells are CD34-positive, and express Gata1, Gata2, C/EBPa, and Pu.1." [GOC:add, GOC:dsd, GOC:tfm, ISBN:0878932437, PMCID:PMC2212039, PMID:10724173, PMID:16551251, PMID:16647566] comment: CMP are reportedly CD16-positive, CD32-positive, CD38-positive, CD45RA-negative, CD110-negative, CD117-positive, CD123-positive, and SCA1-negative. -synonym: "CFU-GEMM" RELATED [ISBN:0878932437] -synonym: "CFU-S" RELATED [ISBN:0878932437] -synonym: "CMP" BROAD [ISBN:0878932437] +synonym: "CFU-GEMM" RELATED abbreviation [ISBN:0878932437] +synonym: "CFU-S" RELATED abbreviation [ISBN:0878932437] +synonym: "CMP" RELATED abbreviation [ISBN:0878932437] synonym: "colony forming unit granulocyte, erythrocyte, macrophage, and megakaryocyte" RELATED [ISBN:0878932437] synonym: "common myeloid precursor, CD34-positive" EXACT [] synonym: "multipotential myeloid stem cell" RELATED [ISBN:0878932437] @@ -13739,10 +13759,10 @@ property_value: dcterms-date "2017-01-30T20:20:48Z" xsd:dateTime id: CL:0001066 name: erythroid progenitor cell, mammalian def: "A progenitor cell committed to the erythroid lineage. This cell is ter119-positive but lacks expression of other hematopoietic lineage markers (lin-negative)." [GOC:add, ISBN:0721601464] -synonym: "BFU-E" RELATED [] +synonym: "BFU-E" RELATED abbreviation [] synonym: "blast forming unit erythroid" RELATED [] synonym: "burst forming unit erythroid" RELATED [] -synonym: "CFU-E" RELATED [] +synonym: "CFU-E" RELATED abbreviation [] synonym: "colony forming unit erythroid" RELATED [] synonym: "erythroid stem cell" RELATED [] xref: BTO:0004911 @@ -15424,7 +15444,7 @@ name: Feyrter cell def: "A neuroendocrine cell found in the epithelium of the lungs and respiratory tract. This cell type is rounded or elliptical in shape, situated mainly in the basal part of the epithelium; regulates bronchial secretion, smooth muscle contraction, lobular growth, ciliary activity and chemoreception. Cell has an electron-lucent cytoplasm, contains numerous dense-cored vesicles with a clear halo between the core and the limiting membrane." [GOC:tfm, ISBN:0412046911, ISBN:0517223651] synonym: "bronchiolar Kulchitsky cell" EXACT [] synonym: "Kultschitzky cell of bronchiole" EXACT [] -synonym: "P cell" BROAD [] +synonym: "P cell" RELATED abbreviation [] synonym: "respiratory enterochromaffin cell" EXACT [] xref: FMA:14118 is_a: CL:0000165 ! neuroendocrine cell @@ -17045,7 +17065,7 @@ creation_date: 2010-08-30T01:27:48Z id: CL:0002195 name: hepatic stem cell def: "A stem cell that can give rise to the cells of the liver. The term usually refers to the self-renewing pool of hepatocyte precursors in the adult liver (differently from 'hepatoblast', often used for fetal precursors of hepatocytes)." [GOC:tfm, PMID:26798363] -synonym: "HpSC" EXACT abbreviation [PMID:18442648] +synonym: "HpSC" RELATED abbreviation [PMID:18442648] xref: FMA:86577 is_a: CL:0000048 {is_inferred="true"} ! multi fate stem cell intersection_of: CL:0000048 ! multi fate stem cell @@ -20133,7 +20153,7 @@ id: CL:0002436 name: mature CD4 single-positive thymocyte def: "A mature CD4-positive, CD8-negative alpha-beta T cell found in the thymus that is CD24-low and has high expression of the T cell receptor." [GOC:tfm, http://www.immgen.org/index_content.html] subset: human_reference_atlas -synonym: "T.4SP24-.Th" RELATED [] +synonym: "T.4SP24-.Th" RELATED abbreviation [] is_a: CL:0000624 {is_inferred="true"} ! CD4-positive, alpha-beta T cell intersection_of: CL:0000624 ! CD4-positive, alpha-beta T cell intersection_of: RO:0015015 GO:0042105 ! has high plasma membrane amount alpha-beta T cell receptor complex @@ -20350,8 +20370,8 @@ name: oligodendrocyte precursor cell def: "A progenitor cell of the central nervous system that can differentiate into oligodendrocytes or type-2 astrocytes. This cell originates from multiple structures within the developing brain including the medial ganglion eminence and the lateral ganglionic eminence. These cells migrate throughout the central nervous system and persist into adulthood where they play an important role in remyelination of injured neurons." [GOC:tfm, PMID:10704434, PMID:11756508, PMID:20142420, PMID:2182078, PMID:24133281, PMID:9826671] comment: This cell type can be purified from optic nerves and other regions of the embryonic, postnatal and adult rat CNS and can be differentiated in vitro to oligodendrocytes and type-2 astrocytes. Some references use the terms 'oligodendrocyte precursor cell' and 'oligodendrocyte type-2 astrocyte (O-2A) progenitor' to refer to the same entity (e.g., PMID:10704434), while others describe an oligodendrocyte type-2 astrocyte (O-2A) progenitor cell as the precurosr to oligodendrocyte- and type-2 astrocyte- progenitor cells (e.g, ISBN:9780702028991). {xref="PMID:10704434", xref="ISBN:9780702028991", xref="PMID:2182078"} subset: human_reference_atlas -synonym: "O-2A/OPC" BROAD [PMID:24133281] -synonym: "O2A/OPC" BROAD [PMID:11756508] +synonym: "O-2A/OPC" RELATED abbreviation [PMID:24133281] +synonym: "O2A/OPC" RELATED abbreviation [PMID:11756508] synonym: "oligodendrocyte-type 2 astrocyte (O-2A) progenitor cell" BROAD [PMID:2253328] synonym: "oligodendrocyte/type-2 astrocyte progenitor cell" BROAD [PMID:24133281] {http://purl.org/dc/terms/contributor="https://orcid.org/0000-0002-0819-0473"} xref: MESH:D000073637 @@ -20665,7 +20685,7 @@ creation_date: 2010-11-23T04:09:09Z id: CL:0002476 name: bone marrow macrophage def: "A tissue-resident macrophage located in the bone marrow. This cell type is B220-negative, CD3e-negative, Ly-6C-negative, CD115-positive, F4/80-positive." [GOC:tfm, http://www.immgen.org/index_content.html] -synonym: "MF.BM" RELATED [] +synonym: "MF.BM" RELATED abbreviation [] xref: BTO:0004732 is_a: CL:0000864 {is_inferred="true"} ! tissue-resident macrophage is_a: CL:1001610 ! bone marrow hematopoietic cell @@ -21564,10 +21584,10 @@ name: fibroblast of choroid plexus def: "A fibroblast that is part of the choroid plexus." [GOC:tfm] is_a: CL:0000057 {is_inferred="true"} ! fibroblast is_a: CL:0002319 ! neural cell -is_a: CL:4023073 ! choroid plexus cell intersection_of: CL:0000057 ! fibroblast intersection_of: part_of UBERON:0001886 ! choroid plexus relationship: dc-contributor https://orcid.org/0000-0003-1980-3228 +relationship: part_of UBERON:0001886 ! choroid plexus creation_date: 2011-02-28T05:01:39Z [Term] @@ -22844,7 +22864,7 @@ name: cardioblast def: "A stem cell that can give rise to multiple cell types (i.e. smooth muscle, endothelial) in the developing heart." [GOC:tfm, PMID:19745164] comment: Discrepancy in develops from origins prevents me from making the assertion that cardioblasts give rise to all instances of cardiocytes as we state cardiac muscle cells develop from cardiac myoblast, which in turn develop from muscle stem cell. synonym: "cardiovascular progenitor cell" EXACT [PMID:17519333, PMID:19745164] -synonym: "CPC" EXACT [PMID:19745164] +synonym: "CPC" RELATED abbreviation [PMID:19745164] is_a: CL:0000048 ! multi fate stem cell relationship: dc-contributor https://orcid.org/0000-0003-1980-3228 creation_date: 2011-07-11T03:15:38Z @@ -23662,7 +23682,7 @@ id: CL:0004120 name: retinal ganglion cell A1 namespace: cell def: "A retinal ganglion A cell found in the retina with large somata, often polygonal in shape. The dendritic fields consist of three to seven stout dendrites that are sparce near soma. Dendrites terminate in S4." [PMID:12209831] -synonym: "I-2" EXACT [] +synonym: "I-2" RELATED [] synonym: "inner alpha retinal ganglion cell" EXACT [] synonym: "type I" BROAD [] xref: BAMS:1045 @@ -23731,9 +23751,9 @@ id: CL:0004138 name: retinal ganglion cell A2 namespace: cell def: "A retinal ganglion A cell with dense arbor near soma." [PMID:12209831] -synonym: "I-1" EXACT [] +synonym: "I-1" RELATED [] synonym: "outer alpha retinal ganglion cell" EXACT [] -synonym: "type I" BROAD [] +synonym: "type I" RELATED [] is_a: CL:0004117 ! retinal ganglion cell A property_value: dc-contributor "https://orcid.org/0000-0001-7258-9596" xsd:string property_value: dc-contributor "https://orcid.org/0000-0002-5260-9315" xsd:string @@ -23860,7 +23880,6 @@ name: flag amacrine cell namespace: cell def: "An amacrine cell with a small, asymteric dendritic field." [PMID:9620701] is_a: CL:0000561 ! amacrine cell -is_a: CL:0000745 ! retina horizontal cell property_value: dc-contributor "https://orcid.org/0000-0001-7258-9596" xsd:string property_value: dc-contributor "https://orcid.org/0000-0002-5260-9315" xsd:string @@ -23892,7 +23911,7 @@ id: CL:0004223 name: AB diffuse-1 amacrine cell namespace: cell def: "A amacrine cell with a small dendritic field and post-synaptic terminals in S1, S2, S3, and S4. AB diffuse-1 amacrine cells have a tent-shaped dendritic arbor and undulate dendrites." [PMID:9620701] -is_a: CL:0000745 ! retina horizontal cell +is_a: CL:0000561 ! amacrine cell relationship: RO:0013001 UBERON:0008922 ! has synaptic IO in region sublaminar layer S1 relationship: RO:0013001 UBERON:0008923 ! has synaptic IO in region sublaminar layer S2 relationship: RO:0013001 UBERON:0008924 ! has synaptic IO in region sublaminar layer S3 @@ -23929,7 +23948,6 @@ name: monostratified amacrine cell namespace: cell def: "An amacrine cell with a small dendritic field with post-synaptic terminals in S3 and S4." [PMID:9620701] is_a: CL:0000561 ! amacrine cell -is_a: CL:0000745 ! retina horizontal cell intersection_of: CL:0000561 ! amacrine cell intersection_of: bearer_of PATO:0070063 ! monostratified dendrite cell morphology relationship: bearer_of PATO:0070063 ! monostratified dendrite cell morphology @@ -23954,7 +23972,7 @@ id: CL:0004228 name: broad diffuse amacrine cell namespace: cell def: "An amacrine cell with a small dendritic field that has post-synaptic terminals in S1, S2, S3, and S4." [PMID:9620701] -is_a: CL:0000745 ! retina horizontal cell +is_a: CL:0000561 ! amacrine cell relationship: RO:0013001 UBERON:0008922 ! has synaptic IO in region sublaminar layer S1 relationship: RO:0013001 UBERON:0008923 ! has synaptic IO in region sublaminar layer S2 relationship: RO:0013001 UBERON:0008924 ! has synaptic IO in region sublaminar layer S3 @@ -24005,7 +24023,6 @@ namespace: cell def: "An amacrine cell with a flat dendritic arbor and a medium dendritic field. Starburst amacrine cells have post-synaptic terminals in S2." [PMID:9620701] subset: human_reference_atlas is_a: CL:0000561 ! amacrine cell -is_a: CL:0000745 ! retina horizontal cell relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens relationship: RO:0013001 UBERON:0008923 ! has synaptic IO in region sublaminar layer S2 property_value: dc-contributor "https://orcid.org/0000-0001-7258-9596" xsd:string @@ -24028,7 +24045,6 @@ name: diffuse multistratified amacrine cell namespace: cell def: "An amacrine cell with a medium dendritic field and post-synaptic terminals in S2, and in S3-S4." [PMID:9620701] is_a: CL:0000561 ! amacrine cell -is_a: CL:0000745 ! retina horizontal cell relationship: RO:0013001 UBERON:0008923 ! has synaptic IO in region sublaminar layer S2 relationship: RO:0013001 UBERON:0009731 ! has synaptic IO in region sublaminar layers S3 or S4 property_value: dc-contributor "https://orcid.org/0000-0001-7258-9596" xsd:string @@ -24040,7 +24056,6 @@ name: AB broad diffuse-1 amacrine cell namespace: cell def: "An amacrine cell with a medium dendritic field and post-synaptic terminals in S2 and S3." [PMID:9620701] is_a: CL:0000561 ! amacrine cell -is_a: CL:0000745 ! retina horizontal cell relationship: RO:0013001 UBERON:0008923 ! has synaptic IO in region sublaminar layer S2 relationship: RO:0013001 UBERON:0008924 ! has synaptic IO in region sublaminar layer S3 property_value: dc-contributor "https://orcid.org/0000-0001-7258-9596" xsd:string @@ -24052,7 +24067,6 @@ name: AB broad diffuse-2 amacrine cell namespace: cell def: "An amacrine cell with a medium dendritic field and post-synaptic terminals in S2, S3, and S4." [PMID:9620701] is_a: CL:0000561 ! amacrine cell -is_a: CL:0000745 ! retina horizontal cell relationship: RO:0013001 UBERON:0008923 ! has synaptic IO in region sublaminar layer S2 relationship: RO:0013001 UBERON:0008924 ! has synaptic IO in region sublaminar layer S3 relationship: RO:0013001 UBERON:0008925 ! has synaptic IO in region sublaminar layer S4 @@ -24065,7 +24079,6 @@ name: fountain amacrine cell namespace: cell def: "A retinal amacrine cell with a medium dendritic field and post-synaptic terminals in S1, S2, S3, and S4." [PMID:9620701] is_a: CL:0000561 ! amacrine cell -is_a: CL:0000745 ! retina horizontal cell relationship: RO:0013001 UBERON:0008922 ! has synaptic IO in region sublaminar layer S1 relationship: RO:0013001 UBERON:0008923 ! has synaptic IO in region sublaminar layer S2 relationship: RO:0013001 UBERON:0008924 ! has synaptic IO in region sublaminar layer S3 @@ -24102,7 +24115,6 @@ name: WF1 amacrine cell namespace: cell def: "An amacrine cell with a wide dendritic field, dendrites in S1, and post-synaptic terminals in S1." [PMID:9620701] is_a: CL:0000561 ! amacrine cell -is_a: CL:0000745 ! retina horizontal cell relationship: RO:0013001 UBERON:0008922 ! has synaptic IO in region sublaminar layer S1 property_value: dc-contributor "https://orcid.org/0000-0001-7258-9596" xsd:string property_value: dc-contributor "https://orcid.org/0000-0002-5260-9315" xsd:string @@ -24113,7 +24125,6 @@ name: WF2 amacrine cell namespace: cell def: "An amacrine cell with a wide dendritic field, dendrites in S2, and post-synaptic terminals in S1." [PMID:9620701] is_a: CL:0000561 ! amacrine cell -is_a: CL:0000745 ! retina horizontal cell relationship: RO:0013001 UBERON:0008922 ! has synaptic IO in region sublaminar layer S1 property_value: dc-contributor "https://orcid.org/0000-0001-7258-9596" xsd:string property_value: dc-contributor "https://orcid.org/0000-0002-5260-9315" xsd:string @@ -24124,7 +24135,6 @@ name: WF3-1 amacrine cell namespace: cell def: "An amacrine cell with a wide dendritic field, dendrites in S3, and post-synaptic terminals in S3. Dendrites of this cell type are straight and minimally branched." [PMID:9620701] is_a: CL:0000561 ! amacrine cell -is_a: CL:0000745 ! retina horizontal cell relationship: RO:0013001 UBERON:0008924 ! has synaptic IO in region sublaminar layer S3 property_value: dc-contributor "https://orcid.org/0000-0001-7258-9596" xsd:string property_value: dc-contributor "https://orcid.org/0000-0002-5260-9315" xsd:string @@ -24135,7 +24145,6 @@ name: WF3-2 amacrine cell namespace: cell def: "An amacrine cell with a wild dendritic field, dendrites in S3, and post-synaptic terminals in S3. Dendrites have spikes, cross over each other, and cover a larger volume than dendrties of W3-1 retinal amacrine cells." [PMID:9620701] is_a: CL:0000561 ! amacrine cell -is_a: CL:0000745 ! retina horizontal cell relationship: RO:0013001 UBERON:0008924 ! has synaptic IO in region sublaminar layer S3 property_value: dc-contributor "https://orcid.org/0000-0001-7258-9596" xsd:string property_value: dc-contributor "https://orcid.org/0000-0002-5260-9315" xsd:string @@ -24146,7 +24155,6 @@ name: WF4 amacrine cell namespace: cell def: "An amacrine cell with a wide dendritic field, dendrites in S4, and post-synaptic terminals in S4." [PMID:9620701] is_a: CL:0000561 ! amacrine cell -is_a: CL:0000745 ! retina horizontal cell relationship: RO:0013001 UBERON:0008925 ! has synaptic IO in region sublaminar layer S4 property_value: dc-contributor "https://orcid.org/0000-0001-7258-9596" xsd:string property_value: dc-contributor "https://orcid.org/0000-0002-5260-9315" xsd:string @@ -24157,7 +24165,6 @@ name: indoleamine-accumulating amacrine cell namespace: cell def: "An amacrine cell with a wide dendritic field and post-synaptic terminals in S5." [PMID:9620701] is_a: CL:0000561 ! amacrine cell -is_a: CL:0000745 ! retina horizontal cell relationship: RO:0013001 UBERON:0008926 ! has synaptic IO in region sublaminar layer S5 property_value: dc-contributor "https://orcid.org/0000-0001-7258-9596" xsd:string property_value: dc-contributor "https://orcid.org/0000-0002-5260-9315" xsd:string @@ -24192,7 +24199,6 @@ name: bistratified retinal amacrine cell namespace: cell def: "An amicrine that stratifies dendrites at two and only two locations." [PMID:9620701] is_a: CL:0000561 ! amacrine cell -is_a: CL:0000745 ! retina horizontal cell is_a: CL:0004247 ! bistratified cell intersection_of: CL:0000561 ! amacrine cell intersection_of: bearer_of PATO:0070062 ! bistratified dendrite cell morphology @@ -24205,7 +24211,6 @@ name: narrow field retinal amacrine cell namespace: cell def: "An amicrine that has a narrow dendritic field." [PMID:9620701] is_a: CL:0000561 ! amacrine cell -is_a: CL:0000745 ! retina horizontal cell property_value: dc-contributor "https://orcid.org/0000-0001-7258-9596" xsd:string property_value: dc-contributor "https://orcid.org/0000-0002-5260-9315" xsd:string @@ -24216,7 +24221,6 @@ namespace: cell def: "An amicrine that has a medium dendritic field." [PMID:9620701] subset: human_reference_atlas is_a: CL:0000561 ! amacrine cell -is_a: CL:0000745 ! retina horizontal cell relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens property_value: dc-contributor "https://orcid.org/0000-0001-7258-9596" xsd:string property_value: dc-contributor "https://orcid.org/0000-0002-5260-9315" xsd:string @@ -24228,7 +24232,6 @@ namespace: cell def: "An amicrine that has a wide dendritic field." [PMID:9620701] subset: human_reference_atlas is_a: CL:0000561 ! amacrine cell -is_a: CL:0000745 ! retina horizontal cell relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens property_value: dc-contributor "https://orcid.org/0000-0001-7258-9596" xsd:string property_value: dc-contributor "https://orcid.org/0000-0002-5260-9315" xsd:string @@ -24350,7 +24353,7 @@ relationship: capable_of GO:0046717 ! acid secretion id: CL:0005012 name: multi-ciliated epithelial cell def: "A ciliated epithelial cell with many cilia." [CL:CVS] -synonym: "MCC" BROAD [] +synonym: "MCC" RELATED abbreviation [] synonym: "multi-ciliated cell" BROAD [] synonym: "multiciliated cell" BROAD [] synonym: "multiciliated epithelial cell" EXACT [] @@ -24420,6 +24423,7 @@ name: lymphangioblast def: "Lymphatic progenitor cells." [CL:CVS] comment: Usually express Prox1, or prox1b. is_a: CL:0000048 {is_inferred="true"} ! multi fate stem cell +is_a: CL:4033054 ! perivascular cell intersection_of: CL:0000048 ! multi fate stem cell intersection_of: adjacent_to UBERON:0004536 ! lymph vasculature relationship: adjacent_to UBERON:0004536 ! lymph vasculature @@ -25048,6 +25052,7 @@ def: "Mural cells are pericytes and the vascular smooth muscle cells (vSMCs) of subset: added_for_HCA subset: human_reference_atlas is_a: CL:0002371 ! somatic cell +is_a: CL:4033054 ! perivascular cell relationship: dc-contributor https://orcid.org/0000-0002-7073-9172 relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens creation_date: 2020-02-29T17:33:55Z @@ -26518,7 +26523,7 @@ def: "A specialized fibroblast found in the medulla of lymph node." [https://orc comment: Origin and phenotype of medullary reticular cells are less well understood in humans than in mice. subset: human_reference_atlas synonym: "lymph node medullary reticular cell" EXACT [] -synonym: "MedRC" BROAD abbreviation [] +synonym: "MedRC" RELATED abbreviation [] synonym: "medullary reticular cell of lymph node" EXACT [] is_a: CL:0009102 ! lymph node fibroblastic reticular cell relationship: dc-contributor https://orcid.org/0000-0002-2825-0621 @@ -27400,6 +27405,8 @@ synonym: "ICLC" RELATED [PMID:20367664] synonym: "interstitial Cajal cell-like cell" NARROW [PMID:20367664] synonym: "interstitial Cajal-like cell" NARROW [PMID:20367664] synonym: "interstitial neuron" RELATED [PMID:31311805] +is_a: CL:0002320 ! connective tissue cell +relationship: has_part GO:0120327 ! telopode relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens created_by: http://orcid.org/0000-0003-2473-2313 @@ -27411,6 +27418,8 @@ subset: blood_and_immune_upper_slim xref: BTO:0000772 xref: EFO:0000572 xref: FMA:83030 +is_a: CL:0000542 ! lymphocyte +relationship: output_of GO:0046649 ! lymphocyte activation property_value: http://purl.org/dc/elements/1.1/date "2022-08-17T14:20:01Z" xsd:string created_by: http://orcid.org/0000-0003-2473-2313 @@ -27929,12 +27938,21 @@ intersection_of: part_of UBERON:0000945 ! stomach [Term] id: CL:1000223 name: lung neuroendocrine cell +def: "A neuroendocrine cell that is part of respiratory epithelium of the lung and is involved in the sensory detection of environmental stimuli, including hypoxia, nicotine and air pressure. Ultrastructurally, this cell type is characterized by the presence of cytoplasmic dense core granules, which are considered the storage sites of amine and peptide hormones. Lung neuroendocrine cells are innervated and appear as solitary cells or as clustered masses, localized at airway bifurcation sites, called neuroepithelial bodies that can release serotonin in response to hypoxia and interact with sensory nerve terminals. Lung neuroendocrine cells also function as reserve stem cells that repair the surrounding epithelium after injury." [doi:10.3109/01902148209069653, doi:10.7554/eLife.78216, PMID:33355253] subset: human_reference_atlas +synonym: "PNEC" RELATED abbreviation [PMID:33355253] +synonym: "pulmonary neuroendocrine cell" EXACT [PMID:33355253] +is_a: CL:0000006 ! neuronal receptor cell is_a: CL:0000082 ! epithelial cell of lung +is_a: CL:0000098 ! sensory epithelial cell is_a: CL:0000165 ! neuroendocrine cell +is_a: CL:0000206 ! chemoreceptor cell +is_a: CL:0000458 ! serotonin secreting cell is_a: CL:1000272 ! lung secretory cell intersection_of: CL:0000165 ! neuroendocrine cell intersection_of: part_of UBERON:0002048 ! lung +relationship: capable_of GO:0070483 ! detection of hypoxia +relationship: has_part GO:0031045 ! dense core granule relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] @@ -33277,7 +33295,7 @@ name: L5 extratelencephalic projecting glutamatergic cortical neuron def: "A glutamatergic neuron, with a soma found in the deeper portion of L5, that has long-range axonal projections including deep subcortical targets outside of the telencephalon and, in some cases, the spinal cord. While the L5 ET neuron projections are not limited to ET targets, they are clearly differentiated from the neuron subclasses whose projections are constrained to intratelencephalic (IT) targets. L5 ET neurons are generally the largest excitatory cortical neurons, typically having a thick apical dendrite with a prominent dendritic tuft in layer 1 and displaying burst-firing physiological characteristics." [DOI:10.1101/2020.10.19.343129] subset: BDS_subset synonym: "burst-firing layer 5 neuron" EXACT [DOI:10.3389/fncel.2011.00001] -synonym: "L5b neuron" BROAD [DOI:10.1016/j.neuron.2011.07.029] +synonym: "L5b neuron" RELATED abbreviation [DOI:10.1016/j.neuron.2011.07.029] synonym: "pyramidal tract (PT) neuron" NARROW [DOI:10.1038/nrn3469] synonym: "Pyramidal tract-like (PT-l)" EXACT [DOI:10.1016/j.cell.2019.09.023] {comment="pyramidal tract-like is used because, unlike pyramidal tract neurons in the motor cortex, neurons in the structures like the auditory cortex do not project to the spinal cord."} synonym: "subcerebral projection (SCPN) neuron" BROAD [DOI:10.1016/j.neuron.2005.08.030] @@ -33690,15 +33708,14 @@ relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: CL:4023073 -name: choroid plexus cell -def: "A cell that is part of the choroid plexus." [DOI:10.1101/2022.10.12.511898] +name: obsolete choroid plexus cell +def: "OBSOLETE. A cell that is part of the choroid plexus." [DOI:10.1101/2022.10.12.511898] +comment: https://github.com/obophenotype/cell-ontology/issues/2043 subset: human_reference_atlas -is_a: CL:0000003 ! native cell -intersection_of: CL:0000003 ! native cell -intersection_of: part_of UBERON:0001886 ! choroid plexus relationship: dc-contributor http://orcid.org/0000-0001-7258-9596 -relationship: part_of UBERON:0001886 ! choroid plexus relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens +is_obsolete: true +replaced_by: CL:0000706 [Term] id: CL:4023074 @@ -33929,8 +33946,8 @@ relationship: dc-contributor https://orcid.org/0000-0001-7258-9596 id: CL:4023097 name: arachnoid barrier cell def: "A mesothelial fibroblast of the arachnoid barrier layer. Arachnoid barrier cells make up the tight-junctioned layer in the leptomeninx that functions as the physiologic barrier between the cerebrospinal fluid in the subarachnoid space and the fenestrated capillaries in the dura." [PMID:23298861] -synonym: "AB cell" EXACT [PMID:23298861] -synonym: "ABC" EXACT [PMID:30096314] +synonym: "AB cell" RELATED abbreviation [PMID:23298861] +synonym: "ABC" RELATED abbreviation [PMID:30096314] is_a: CL:4023058 ! mesothelial fibroblast of the leptomeninx relationship: dc-contributor https://orcid.org/0000-0001-7258-9596 relationship: part_of UBERON:0000437 ! arachnoid barrier layer @@ -34195,7 +34212,7 @@ id: CL:4023122 name: oxytocin receptor sst GABAergic cortical interneuron def: "An interneuron located in the cerebral cortex that expresses the oxytocin receptor. These interneurons also express somatostatin." [PMID:25303526] comment: These cells were first identified in mouse. {xref="PMID:25303526"} -synonym: "OxtrINs" BROAD [PMID:25303526] +synonym: "OxtrINs" RELATED abbreviation [PMID:25303526] is_a: CL:4023017 ! sst GABAergic cortical interneuron relationship: dc-contributor https://orcid.org/0000-0001-7258-9596 relationship: present_in_taxon NCBITaxon:10090 {xref="PMID:25303526"} ! Mus musculus @@ -34471,9 +34488,9 @@ id: CL:4028002 name: alveolar capillary type 1 endothelial cell def: "An alveolar capillary endothelial cell that is located distally to alveolar capillary type 2 endothelial cells." [PMID:31233341, PMID:32059772, PMID:32059779, PMID:32091393, PMID:33057196, PMID:33705684] subset: human_reference_atlas -synonym: "CAP1" BROAD [] +synonym: "CAP1" RELATED [] {comment="abbreviation"} synonym: "capillary 1 cell" BROAD [] -synonym: "gCAP" BROAD [PMID:33057196] +synonym: "gCAP" RELATED [PMID:33057196] {comment="abbreviation"} synonym: "general capillary cell" BROAD [PMID:33057196] is_a: CL:0010003 ! epithelial cell of alveolus of lung is_a: CL:4028001 ! pulmonary capillary endothelial cell @@ -34486,7 +34503,7 @@ id: CL:4028003 name: alveolar capillary type 2 endothelial cell def: "An alveolar capillary endothelial cell that is located proximally to alveolar capillary type 1 endothelial cells and in close apposition to alveolar type 1 epithelial cells (also known as type I pneumocytes)." [PMID:31233341, PMID:32059772, PMID:32059779, PMID:32091393, PMID:33057196] subset: human_reference_atlas -synonym: "aCAP" BROAD [] +synonym: "aCAP" RELATED abbreviation [] synonym: "aerocyte" BROAD [PMID:33057196] synonym: "alveolar capillary cell" BROAD [] synonym: "capillary 2 cell" BROAD [] @@ -34503,7 +34520,7 @@ id: CL:4028004 name: alveolar type 1 fibroblast cell def: "A pulmonary interstitial fibroblast that is part of the alveolus and contains lipid droplets." [PMID:22268140, PMID:26706109, PMID:28886382, PMID:29489752, PMID:30675802, PMID:33624948, PMID:33707239, PMID:9074756] subset: human_reference_atlas -synonym: "AF1" BROAD [] +synonym: "AF1" RELATED abbreviation [] synonym: "alveolar fibroblast" BROAD [] synonym: "alveolar fibroblast 1" BROAD [] synonym: "lipid interstitial cell" BROAD [] @@ -34526,9 +34543,9 @@ name: alveolar type 2 fibroblast cell def: "A pulmonary interstitial fibroblast that is part of the alveolus and localizes to vascular adventitia." [PMID:26706109, PMID:28886382, PMID:29752282, PMID:30675802, PMID:33208946, PMID:33624948] subset: human_reference_atlas synonym: "adventitial fibroblast" BROAD [] -synonym: "AF2" BROAD [] +synonym: "AF2" RELATED abbreviation [] synonym: "alveolar fibroblast" BROAD [] -synonym: "MANC" BROAD [] +synonym: "MANC" RELATED abbreviation [] synonym: "matrix fibroblast 2" BROAD [] synonym: "mesenchymal alveolar niche cell" BROAD [] synonym: "type-2 associated stromal cell" BROAD [] @@ -35099,58 +35116,58 @@ property_value: dcterms-date "2023-02-09T11:37:30Z" xsd:dateTime [Term] id: CL:4030043 name: matrix D1 medium spiny neuron -def: "A DRD1-expressing medium spiny neuron that is part of a matrix compartment of dorsal striatum." [DOI:10.1016/j.cub.2021.10.015] -comment: In Rhesus macaques, both matrix D1 and D2 medium spiny neuron cell types have been noted to have enriched gene expression of the following: EPHA4, GDA, STXBP6, and SEMA3E. Broadly understood, matrix MSNs receive neocortical inputs from the associative and sensorimotor cortex and give rise to the direct and indirect pathways. {xref="DOI:10.1016/j.cub.2021.10.015"} -synonym: "D1-matrix" RELATED abbreviation [DOI:10.1016/j.cub.2021.10.015] -synonym: "D1M" RELATED abbreviation [DOI:10.1016/j.cub.2021.10.015] -synonym: "matrix D1-MSN" RELATED abbreviation [DOI:10.1016/j.cub.2021.10.015] +def: "A DRD1-expressing medium spiny neuron that is part of a matrix compartment of dorsal striatum." [doi:10.1016/j.cub.2021.10.015] +comment: In Rhesus macaques, both matrix D1 and D2 medium spiny neuron cell types have been noted to have enriched gene expression of the following: EPHA4, GDA, STXBP6, and SEMA3E. Broadly understood, matrix MSNs receive neocortical inputs from the associative and sensorimotor cortex and give rise to the direct and indirect pathways. {xref="doi:10.1016/j.cub.2021.10.015"} +synonym: "D1-matrix" RELATED abbreviation [doi:10.1016/j.cub.2021.10.015] +synonym: "D1M" RELATED abbreviation [doi:10.1016/j.cub.2021.10.015] +synonym: "matrix D1-MSN" RELATED abbreviation [doi:10.1016/j.cub.2021.10.015] is_a: CL:4023026 ! direct pathway medium spiny neuron property_value: dcterms-date "2023-06-02T14:05:03Z" xsd:dateTime [Term] id: CL:4030047 name: matrix D2 medium spiny neuron -def: "A DRD2-expressing medium spiny neuron that is part of a matrix compartment of dorsal striatum." [DOI:10.1016/j.cub.2021.10.015] -comment: In Rhesus macaques, both matrix D1 and D2 medium spiny neuron cell types have been noted to have enriched gene expression of the following: EPHA4, GDA, STXBP6, and SEMA3E. Broadly understood, matrix MSNs receive neocortical inputs from the associative and sensorimotor cortex and give rise to the direct and indirect pathways. {xref="DOI:10.1016/j.cub.2021.10.015"} -synonym: "D2-matrix" RELATED abbreviation [DOI:10.1016/j.cub.2021.10.015] -synonym: "D2M" RELATED abbreviation [DOI:10.1016/j.cub.2021.10.015] -synonym: "matrix D2-MSN" RELATED abbreviation [DOI:10.1016/j.cub.2021.10.015] +def: "A DRD2-expressing medium spiny neuron that is part of a matrix compartment of dorsal striatum." [doi:10.1016/j.cub.2021.10.015] +comment: In Rhesus macaques, both matrix D1 and D2 medium spiny neuron cell types have been noted to have enriched gene expression of the following: EPHA4, GDA, STXBP6, and SEMA3E. Broadly understood, matrix MSNs receive neocortical inputs from the associative and sensorimotor cortex and give rise to the direct and indirect pathways. {xref="doi:10.1016/j.cub.2021.10.015"} +synonym: "D2-matrix" RELATED abbreviation [doi:10.1016/j.cub.2021.10.015] +synonym: "D2M" RELATED abbreviation [doi:10.1016/j.cub.2021.10.015] +synonym: "matrix D2-MSN" RELATED abbreviation [doi:10.1016/j.cub.2021.10.015] is_a: CL:4023029 ! indirect pathway medium spiny neuron property_value: dcterms-date "2023-06-02T14:40:25Z" xsd:dateTime [Term] id: CL:4030048 name: striosomal D1 medium spiny neuron -def: "A DRD1-expressing medium spiny neuron that is part of a striosome of dorsal striatum." [DOI:10.1016/j.cub.2021.10.015] -comment: In Rhesus macaques, both striosomal D1 and D2 medium spiny neuron (MSN) cell types have been noted to have enriched gene expression of the following: KCNT1, KHDRBS3, FAM163A, BACH2, and KCNIP1. Striosomal MSN activations have been noted to influence cognitive and emotional decision making and value-based learning. In contrast to matrix MSNs, striosomal MSNs receive input from limbic territories, including the anterior cingulate cortex, orbitofrontal cortex, and anterior insular cortex, and project directly to midbrain dopamine neurons. {xref="DOI:10.1016/j.cub.2021.10.015"} +def: "A DRD1-expressing medium spiny neuron that is part of a striosome of dorsal striatum." [doi:10.1016/j.cub.2021.10.015] +comment: In Rhesus macaques, both striosomal D1 and D2 medium spiny neuron (MSN) cell types have been noted to have enriched gene expression of the following: KCNT1, KHDRBS3, FAM163A, BACH2, and KCNIP1. Striosomal MSN activations have been noted to influence cognitive and emotional decision making and value-based learning. In contrast to matrix MSNs, striosomal MSNs receive input from limbic territories, including the anterior cingulate cortex, orbitofrontal cortex, and anterior insular cortex, and project directly to midbrain dopamine neurons. {xref="doi:10.1016/j.cub.2021.10.015"} synonym: "D1-striosome" RELATED abbreviation [DOI:10.1016/j.cub.2021.10.015] -synonym: "D1S" RELATED abbreviation [DOI:10.1016/j.cub.2021.10.015] -synonym: "striosome D1 medium spiny neuron" EXACT [DOI:10.1016/j.cub.2021.10.015] -synonym: "striosome D1-MSN" RELATED abbreviation [DOI:10.1016/j.cub.2021.10.015] +synonym: "D1S" RELATED abbreviation [doi:10.1016/j.cub.2021.10.015] +synonym: "striosome D1 medium spiny neuron" EXACT [doi:10.1016/j.cub.2021.10.015] +synonym: "striosome D1-MSN" RELATED abbreviation [doi:10.1016/j.cub.2021.10.015] is_a: CL:4023026 ! direct pathway medium spiny neuron property_value: dcterms-date "2023-06-02T14:50:43Z" xsd:dateTime [Term] id: CL:4030049 name: striosomal D2 medium spiny neuron -def: "A DRD2-expressing medium spiny neuron that is part of a striosome of dorsal striatum." [DOI:10.1016/j.cub.2021.10.015] -comment: In Rhesus macaques, both striosomal D1 and D2 medium spiny neuron (MSN) cell types have been noted to have enriched gene expression of the following: KCNT1, KHDRBS3, FAM163A, BACH2, and KCNIP1. Striosomal MSN activations have been noted to influence cognitive and emotional decision making and value-based learning. In contrast to matrix MSNs, striosomal MSNs receive input from limbic territories, including the anterior cingulate cortex, orbitofrontal cortex, and anterior insular cortex, and project directly to midbrain dopamine neurons. {xref="DOI:10.1016/j.cub.2021.10.015"} -synonym: "D2-striosome" RELATED abbreviation [DOI:10.1016/j.cub.2021.10.015] -synonym: "D2S" RELATED abbreviation [DOI:10.1016/j.cub.2021.10.015] -synonym: "striosome D2 medium spiny neuron" EXACT [DOI:10.1016/j.cub.2021.10.015] -synonym: "striosome D2-MSN" RELATED abbreviation [DOI:10.1016/j.cub.2021.10.015] +def: "A DRD2-expressing medium spiny neuron that is part of a striosome of dorsal striatum." [doi:10.1016/j.cub.2021.10.015] +comment: In Rhesus macaques, both striosomal D1 and D2 medium spiny neuron (MSN) cell types have been noted to have enriched gene expression of the following: KCNT1, KHDRBS3, FAM163A, BACH2, and KCNIP1. Striosomal MSN activations have been noted to influence cognitive and emotional decision making and value-based learning. In contrast to matrix MSNs, striosomal MSNs receive input from limbic territories, including the anterior cingulate cortex, orbitofrontal cortex, and anterior insular cortex, and project directly to midbrain dopamine neurons. {xref="doi:10.1016/j.cub.2021.10.015"} +synonym: "D2-striosome" RELATED abbreviation [doi:10.1016/j.cub.2021.10.015] +synonym: "D2S" RELATED abbreviation [doi:10.1016/j.cub.2021.10.015] +synonym: "striosome D2 medium spiny neuron" EXACT [doi:10.1016/j.cub.2021.10.015] +synonym: "striosome D2-MSN" RELATED abbreviation [doi:10.1016/j.cub.2021.10.015] is_a: CL:4023029 ! indirect pathway medium spiny neuron property_value: dcterms-date "2023-06-02T15:03:08Z" xsd:dateTime [Term] id: CL:4030050 name: D1/D2-hybrid medium spiny neuron -def: "A medium spiny neuron that expresses both DRD1 and DRD2 and is part of an extra-striosomal part of dorsal striatum." [DOI:10.1016/j.cub.2021.10.015] -comment: It has been noted in non-human primate species that the D1/D2-hybrid medium spiny neuron (D1/2) cell type shows the same amount of DRD1 expression as nearby D1 medium spiny neurons but far less DRD2 expression compared to nearby D2 medium spiny neurons. In Rhesus macaques, RXFP1 has been noted as a highly specific marker gene for the D1/2 cell type. The D1/2 cell type has also been described as having characteristics similar to a novel medium spiny neuron described in rodents (D1H or eccentric spiny projection neuron). Although an extrastriosomal cell type, the D1/2 cell type had been noted to express many of the genes associated with striosome, suggesting a possible homology to ‘‘exo-patch’’ cells. {xref="DOI:10.1016/j.cub.2021.10.015"} -synonym: "D1/2" RELATED abbreviation [DOI:10.1016/j.cub.2021.10.015] -synonym: "D1/D2 hybrid" RELATED abbreviation [DOI:10.1016/j.cub.2021.10.015] -synonym: "D1/D2-hybrid MSN" RELATED abbreviation [DOI:10.1016/j.cub.2021.10.015] -synonym: "hybrid D1/2 cell type" RELATED abbreviation [DOI:10.1016/j.cub.2021.10.015] +def: "A medium spiny neuron that expresses both DRD1 and DRD2 and is part of an extra-striosomal part of dorsal striatum." [doi:10.1016/j.cub.2021.10.015] +comment: It has been noted in non-human primate species that the D1/D2-hybrid medium spiny neuron (D1/2) cell type shows the same amount of DRD1 expression as nearby D1 medium spiny neurons but far less DRD2 expression compared to nearby D2 medium spiny neurons. In Rhesus macaques, RXFP1 has been noted as a highly specific marker gene for the D1/2 cell type. The D1/2 cell type has also been described as having characteristics similar to a novel medium spiny neuron described in rodents (D1H or eccentric spiny projection neuron). Although an extrastriosomal cell type, the D1/2 cell type had been noted to express many of the genes associated with striosome, suggesting a possible homology to ‘‘exo-patch’’ cells. {xref="doi:10.1016/j.cub.2021.10.015"} +synonym: "D1/2" RELATED abbreviation [doi:10.1016/j.cub.2021.10.015] +synonym: "D1/D2 hybrid" RELATED abbreviation [doi:10.1016/j.cub.2021.10.015] +synonym: "D1/D2-hybrid MSN" RELATED abbreviation [doi:10.1016/j.cub.2021.10.015] +synonym: "hybrid D1/2 cell type" RELATED abbreviation [doi:10.1016/j.cub.2021.10.015] is_a: CL:1001474 ! medium spiny neuron relationship: RO:0002100 UBERON:0005382 ! has soma location dorsal striatum relationship: RO:0002292 PR:000001175 ! expresses D(1A) dopamine receptor @@ -35845,6 +35862,34 @@ relationship: dc-contributor https://orcid.org/0000-0001-6677-8489 relationship: dc-contributor https://orcid.org/0000-0002-9185-3994 property_value: dcterms-date "2023-06-21T10:04:46Z" xsd:dateTime +[Term] +id: CL:4033046 +name: ON midget ganglion cell +def: "A midget ganglion cell that depolarizes in response to increased light intensity in the center of its receptive field. The majority of input that this cell receives comes from invaginating midget bipolar cells." [PMID:32032773] +synonym: "inner stratifying midget cell" EXACT [PMID:32032773] +synonym: "ON-midget cell" EXACT [PMID:34093409] +synonym: "ON-midget RGC" EXACT [PMID:34093409] +is_a: CL:4023032 ! ON retinal ganglion cell +is_a: CL:4023188 ! midget ganglion cell of retina +intersection_of: CL:4023032 ! ON retinal ganglion cell +intersection_of: CL:4023188 ! midget ganglion cell of retina +relationship: dc-contributor https://orcid.org/0000-0001-6677-8489 +property_value: dcterms-date "2023-08-08T09:40:08Z" xsd:dateTime + +[Term] +id: CL:4033047 +name: OFF midget ganglion cell +def: "A midget ganglion cell that depolarizes in response to decreased light intensity in the center of its receptive field. The majority of input that this cell receives comes from flat midget bipolar cells." [PMID:32032773] +synonym: "OFF-midget cell" EXACT [PMID:34093409] +synonym: "OFF-midget RGC" EXACT [PMID:34093409] +synonym: "outer stratifying midget cell" EXACT [PMID:32032773] +is_a: CL:4023033 ! OFF retinal ganglion cell +is_a: CL:4023188 ! midget ganglion cell of retina +intersection_of: CL:4023033 ! OFF retinal ganglion cell +intersection_of: CL:4023188 ! midget ganglion cell of retina +relationship: dc-contributor https://orcid.org/0000-0001-6677-8489 +property_value: dcterms-date "2023-08-08T11:05:37Z" xsd:dateTime + [Term] id: CL:4033048 name: respiratory suprabasal cell @@ -35887,6 +35932,59 @@ relationship: capable_of GO:0160043 ! catecholamine secretion, neurotransmission relationship: dc-contributor https://orcid.org/0000-0001-6677-8489 property_value: dcterms-date "2023-05-18T12:07:45Z" xsd:dateTime +[Term] +id: CL:4033051 +name: OFF parasol ganglion cell +def: "A parasol ganglion cell that depolarizes in response to decreased light intensity in the center of its receptive field. The majority of input that this cell receives comes from DB3a bipolar cells." [PMID:32032773] +synonym: "OFF-parasol retinal ganglion cell" EXACT [PMID:34093409] +synonym: "OFF-parasol RGC" EXACT [PMID:34093409] +synonym: "outer parasol cell" EXACT [PMID:32032773] +is_a: CL:4023033 ! OFF retinal ganglion cell +is_a: CL:4023189 ! parasol ganglion cell of retina +intersection_of: CL:4023033 ! OFF retinal ganglion cell +intersection_of: CL:4023189 ! parasol ganglion cell of retina +relationship: dc-contributor https://orcid.org/0000-0001-6677-8489 +property_value: dcterms-date "2023-08-08T12:34:57Z" xsd:dateTime + +[Term] +id: CL:4033052 +name: ON parasol ganglion cell +def: "A parasol ganglion cell that depolarizes in response to increased light intensity in the center of its receptive field. The majority of input that this cell receives comes from DB4 bipolar cells." [PMID:32032773] +synonym: "inner parasol cell" EXACT [PMID:32032773] +synonym: "ON-parasol retinal ganglion cell" EXACT [PMID:34093409] +synonym: "ON-parasol RGC" EXACT [PMID:34093409] +is_a: CL:4023032 ! ON retinal ganglion cell +is_a: CL:4023189 ! parasol ganglion cell of retina +intersection_of: CL:4023032 ! ON retinal ganglion cell +intersection_of: CL:4023189 ! parasol ganglion cell of retina +relationship: dc-contributor https://orcid.org/0000-0001-6677-8489 +property_value: dcterms-date "2023-08-08T12:39:35Z" xsd:dateTime + +[Term] +id: CL:4033053 +name: small bistratified retinal ganglion cell +def: "A bistratfied retinal ganglion cell with a small dendritic field that has dendrites in the ON and OFF sublamina of the retinal inner plexiform layer and carries blue-ON/yellow-OFF signals. This cell receives bipolar and amacrine input to both the OFF and ON dendritic tree." [PMID:32032773] +synonym: "Polyak's shrub cell" RELATED [PMID:32032773] +synonym: "sbRGC" RELATED abbreviation [PMID:34093409] +synonym: "SBS ganglion cell" RELATED abbreviation [PMID:32032773] +synonym: "small bistratified cell" EXACT [PMID:32032773] +synonym: "small bistratified cell, blue-ON/yellow-OFF ganglion cell" EXACT [doi:10.1002/cne.22183] +is_a: CL:0003001 ! bistratified retinal ganglion cell +relationship: dc-contributor https://orcid.org/0000-0001-6677-8489 +relationship: RO:0002100 UBERON:0001792 ! has soma location ganglionic layer of retina +property_value: dcterms-date "2023-08-08T12:43:56Z" xsd:dateTime + +[Term] +id: CL:4033054 +name: perivascular cell +def: "A cell that is adjacent to a vessel. A perivascular cell plays a crucial role in maintaining vascular function and tissue homeostasis. This cell type regulates vessel integrity and flow dynamics." [PMID:24928499, PMID:27889329] +is_a: CL:0000003 ! native cell +intersection_of: CL:0000003 ! native cell +intersection_of: adjacent_to UBERON:0002049 ! vasculature +relationship: adjacent_to UBERON:0002049 ! vasculature +relationship: dc-contributor https://orcid.org/0000-0001-6677-8489 +property_value: dcterms-date "2023-08-22T13:40:28Z" xsd:dateTime + [Term] id: CL:4040000 name: glial restricted tripotential precursor cell @@ -36037,27 +36135,6 @@ intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0006310 ! DNA recombination relationship: regulates GO:0006310 ! DNA recombination -[Term] -id: GO:0000045 -name: autophagosome assembly -namespace: biological_process -def: "The formation of a double membrane-bounded structure, the autophagosome, that occurs when a specialized membrane sac, called the isolation membrane, starts to enclose a portion of the cytoplasm." [GOC:autophagy, PMID:9412464] -synonym: "autophagic vacuole assembly" EXACT [GOC:autophagy] -synonym: "autophagic vacuole formation" RELATED [GOC:mah] -synonym: "autophagosome biosynthesis" EXACT [] -synonym: "autophagosome formation" EXACT [] -synonym: "PAS formation" NARROW [] -is_a: GO:0070925 ! organelle assembly -is_a: GO:1905037 ! autophagosome organization -intersection_of: GO:0022607 ! cellular component assembly -intersection_of: results_in_assembly_of GO:0005776 ! autophagosome -relationship: has_part GO:0019778 ! Atg12 activating enzyme activity -relationship: has_part GO:0019786 ! protein-phosphatidylethanolamide deconjugating activity -relationship: has_part GO:0061651 ! Atg12 conjugating enzyme activity -relationship: has_part GO:0061660 ! Atg12 ligase activity -relationship: results_in_assembly_of GO:0005776 ! autophagosome -relationship: starts_with GO:1904745 ! Atg1/ULK1 kinase complex assembly - [Term] id: GO:0000070 name: mitotic sister chromatid segregation @@ -36205,18 +36282,6 @@ namespace: cellular_component def: "A vacuole that is maintained at an acidic pH and which contains degradative enzymes, including a wide variety of acid hydrolases." [GOC:krc] is_a: GO:0005773 ! vacuole -[Term] -id: GO:0000421 -name: autophagosome membrane -namespace: cellular_component -def: "The lipid bilayer surrounding an autophagosome, a double-membrane-bounded vesicle in which endogenous cellular material is sequestered." [GOC:autophagy, GOC:isa_complete] -synonym: "autophagic vacuole membrane" EXACT [GOC:autophagy] -is_a: GO:0005774 ! vacuolar membrane -intersection_of: GO:0016020 ! membrane -intersection_of: bounding_layer_of GO:0005776 ! autophagosome -relationship: bounding_layer_of GO:0005776 ! autophagosome -relationship: part_of GO:0005776 ! autophagosome - [Term] id: GO:0000578 name: embryonic axis specification @@ -36345,16 +36410,6 @@ intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: results_in_morphogenesis_of CL:0000000 ! cell relationship: results_in_morphogenesis_of CL:0000000 ! cell -[Term] -id: GO:0000904 -name: cell morphogenesis involved in differentiation -namespace: biological_process -def: "The change in form (cell shape and size) that occurs when relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history." [GOC:go_curators] -is_a: GO:0000902 ! cell morphogenesis -intersection_of: GO:0000902 ! cell morphogenesis -intersection_of: part_of GO:0048468 ! cell development -relationship: part_of GO:0048468 ! cell development - [Term] id: GO:0001101 name: response to acid chemical @@ -36393,6 +36448,19 @@ intersection_of: GO:0032501 ! multicellular organismal process intersection_of: results_in_formation_of UBERON:0001474 ! bone element relationship: results_in_formation_of UBERON:0001474 ! bone element +[Term] +id: GO:0001504 +name: neurotransmitter uptake +namespace: biological_process +def: "The directed movement of neurotransmitters into neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters." [ISBN:0123668387] +subset: goslim_synapse +synonym: "neurotransmitter import" EXACT [GOC:dph, GOC:tb] +synonym: "neurotransmitter import into glial cell" NARROW [] +synonym: "neurotransmitter import into neuron" NARROW [] +synonym: "neurotransmitter recycling" BROAD [] +is_a: GO:0001505 ! regulation of neurotransmitter levels +is_a: GO:0006836 ! neurotransmitter transport + [Term] id: GO:0001505 name: regulation of neurotransmitter levels @@ -36717,6 +36785,19 @@ synonym: "G-protein-coupled receptor ligand" NARROW [] xref: Reactome:R-HSA-500717 "Activation of GRIK3 homomer" is_a: GO:0005102 ! signaling receptor binding +[Term] +id: GO:0001666 +name: response to hypoxia +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:hjd] +comment: Note that this term should not be confused with 'response to anoxia ; GO:0034059'. Note that in laboratory studies, hypoxia is typically studied at O2 concentrations ranging from 0.1 - 5%. +synonym: "response to hypoxic stress" EXACT [] +synonym: "response to intermittent hypoxia" NARROW [] +synonym: "response to lowered oxygen tension" EXACT [] +synonym: "response to sustained hypoxia" NARROW [] +is_a: GO:0006950 ! response to stress +is_a: GO:0036293 ! response to decreased oxygen levels + [Term] id: GO:0001667 name: ameboidal-type cell migration @@ -37477,7 +37558,7 @@ namespace: biological_process def: "The morphogenesis of trophectoderm cells." [GOC:dph, ISBN:0124020607, ISBN:0198542771] comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, trophectoderm ; EMAP:19', 'TS5, trophectoderm ; EMAP:28' and 'TS6, trophectoderm ; EMAP:39'. synonym: "trophectoderm cellular morphogenesis" EXACT [] -is_a: GO:0000904 ! cell morphogenesis involved in differentiation +is_a: GO:0000902 ! cell morphogenesis is_a: GO:0048598 ! embryonic morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: results_in_morphogenesis_of CL:1000274 ! trophectodermal cell @@ -37655,18 +37736,6 @@ intersection_of: GO:0050896 ! response to stimulus intersection_of: has_input NCBITaxon:147537 ! Saccharomycotina relationship: has_input NCBITaxon:147537 ! Saccharomycotina -[Term] -id: GO:0001880 -name: Mullerian duct regression -namespace: biological_process -def: "The process in which the Mullerian ducts, primordia of the oviducts, uterus and upper vagina, undergo regression in male embryos." [GOC:dph, PMID:12368913] -is_a: GO:0003006 ! developmental process involved in reproduction -is_a: GO:0060033 ! anatomical structure regression -intersection_of: GO:0060033 ! anatomical structure regression -intersection_of: has_input UBERON:0003890 ! Mullerian duct -relationship: has_input UBERON:0003890 ! Mullerian duct -relationship: part_of GO:0046661 ! male sex differentiation - [Term] id: GO:0001885 name: endothelial cell development @@ -38419,6 +38488,84 @@ synonym: "regulation of heart contraction rate" EXACT [] synonym: "regulation of rate of heart contraction" EXACT [] is_a: GO:0008016 ! regulation of heart contraction +[Term] +id: GO:0002036 +name: regulation of L-glutamate import across plasma membrane +namespace: biological_process +alt_id: GO:1900920 +def: "Any process that modulates the frequency, rate or extent of L-glutamate import into a cell." [GOC:TermGenie] +synonym: "regulation of L-glutamate import" BROAD [] +synonym: "regulation of L-glutamate transport" BROAD [] +synonym: "regulation of L-glutamate uptake" EXACT [GOC:TermGenie] +is_a: GO:0010958 ! regulation of amino acid import across plasma membrane +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:0098712 ! L-glutamate import across plasma membrane +relationship: regulates GO:0098712 ! L-glutamate import across plasma membrane +created_by: al +creation_date: 2012-06-13T07:34:08Z + +[Term] +id: GO:0002037 +name: negative regulation of L-glutamate import across plasma membrane +namespace: biological_process +alt_id: GO:1900921 +def: "Any process that stops, prevents or reduces the frequency, rate or extent of L-glutamate import into a cell." [GOC:TermGenie] +synonym: "down regulation of L-glutamate import" EXACT [GOC:TermGenie] +synonym: "down regulation of L-glutamate transport" BROAD [] +synonym: "down regulation of L-glutamate uptake" RELATED [GOC:TermGenie] +synonym: "down-regulation of L-glutamate import" EXACT [GOC:TermGenie] +synonym: "down-regulation of L-glutamate transport" BROAD [] +synonym: "down-regulation of L-glutamate uptake" RELATED [GOC:TermGenie] +synonym: "downregulation of L-glutamate import" EXACT [GOC:TermGenie] +synonym: "downregulation of L-glutamate transport" BROAD [] +synonym: "downregulation of L-glutamate uptake" RELATED [GOC:TermGenie] +synonym: "inhibition of L-glutamate import" NARROW [GOC:TermGenie] +synonym: "inhibition of L-glutamate transport" NARROW [] +synonym: "inhibition of L-glutamate uptake" NARROW [GOC:TermGenie] +synonym: "negative regulation of L-glutamate import" BROAD [] +synonym: "negative regulation of L-glutamate transport" BROAD [] +synonym: "negative regulation of L-glutamate uptake" RELATED [GOC:TermGenie] +synonym: "regulation of L-glutamate import" BROAD [] +is_a: GO:0002036 ! regulation of L-glutamate import across plasma membrane +is_a: GO:0034763 ! negative regulation of transmembrane transport +is_a: GO:0051956 ! negative regulation of amino acid transport +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:0098712 ! L-glutamate import across plasma membrane +relationship: negatively_regulates GO:0098712 ! L-glutamate import across plasma membrane +created_by: al +creation_date: 2012-06-13T07:34:30Z + +[Term] +id: GO:0002038 +name: positive regulation of L-glutamate import across plasma membrane +namespace: biological_process +alt_id: GO:1900922 +def: "Any process that activates or increases the frequency, rate or extent of L-glutamate import into a cell." [GOC:TermGenie] +synonym: "activation of L-glutamate import" NARROW [GOC:TermGenie] +synonym: "activation of L-glutamate transport" NARROW [] +synonym: "activation of L-glutamate uptake" NARROW [GOC:TermGenie] +synonym: "positive regulation of L-glutamate import" BROAD [] +synonym: "positive regulation of L-glutamate transport" BROAD [] +synonym: "positive regulation of L-glutamate uptake" RELATED [GOC:TermGenie] +synonym: "stimulation of L-glutamate transport" NARROW [] +synonym: "up regulation of L-glutamate import" EXACT [GOC:TermGenie] +synonym: "up regulation of L-glutamate transport" BROAD [] +synonym: "up regulation of L-glutamate uptake" RELATED [GOC:TermGenie] +synonym: "up-regulation of L-glutamate import" EXACT [GOC:TermGenie] +synonym: "up-regulation of L-glutamate transport" EXACT [] +synonym: "up-regulation of L-glutamate uptake" RELATED [GOC:TermGenie] +synonym: "upregulation of L-glutamate import" EXACT [GOC:TermGenie] +synonym: "upregulation of L-glutamate transport" BROAD [] +synonym: "upregulation of L-glutamate uptake" RELATED [GOC:TermGenie] +is_a: GO:0002036 ! regulation of L-glutamate import across plasma membrane +is_a: GO:0034764 ! positive regulation of transmembrane transport +is_a: GO:0051957 ! positive regulation of amino acid transport +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates GO:0098712 ! L-glutamate import across plasma membrane +relationship: positively_regulates GO:0098712 ! L-glutamate import across plasma membrane +created_by: al +creation_date: 2012-06-13T07:34:38Z + [Term] id: GO:0002052 name: positive regulation of neuroblast proliferation @@ -38704,6 +38851,59 @@ relationship: acts_on_population_of CL:0000015 ! male germ cell created_by: hjd creation_date: 2010-11-18T02:35:14Z +[Term] +id: GO:0002181 +name: cytoplasmic translation +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein." [GOC:hjd] +comment: Note that this term applies to translation performed by cytoplasmic ribosomes, which is distinct from translation performed by organellar ribosomes. For mitochondrial translation, consider GO:0032543 'mitochondrial translation' or its child terms. +subset: goslim_generic +subset: goslim_pombe +subset: goslim_yeast +is_a: GO:0006412 ! translation +intersection_of: GO:0006412 ! translation +intersection_of: process_has_causal_agent GO:0022626 ! cytosolic ribosome +relationship: process_has_causal_agent GO:0022626 ! cytosolic ribosome +created_by: hjd +creation_date: 2011-06-09T03:11:53Z + +[Term] +id: GO:0002182 +name: cytoplasmic translational elongation +namespace: biological_process +def: "The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis in the cytoplasm." [GOC:hjd] +is_a: GO:0006414 ! translational elongation +intersection_of: GO:0006414 ! translational elongation +intersection_of: part_of GO:0002181 ! cytoplasmic translation +relationship: part_of GO:0002181 ! cytoplasmic translation +created_by: hjd +creation_date: 2011-06-09T03:14:42Z + +[Term] +id: GO:0002183 +name: cytoplasmic translational initiation +namespace: biological_process +def: "The process preceding formation of the peptide bond between the first two amino acids of a protein in the cytoplasm. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA." [GOC:hjd] +is_a: GO:0006413 ! translational initiation +intersection_of: GO:0006413 ! translational initiation +intersection_of: part_of GO:0002181 ! cytoplasmic translation +relationship: part_of GO:0002181 ! cytoplasmic translation +created_by: hjd +creation_date: 2011-06-09T03:15:48Z + +[Term] +id: GO:0002184 +name: cytoplasmic translational termination +namespace: biological_process +def: "The process resulting in the release of a polypeptide chain from the ribosome in the cytoplasm, usually in response to a termination codon." [GOC:hjd] +is_a: GO:0006415 ! translational termination +intersection_of: GO:0006415 ! translational termination +intersection_of: occurs_in GO:0005829 ! cytosol +relationship: occurs_in GO:0005829 ! cytosol +relationship: part_of GO:0002181 ! cytoplasmic translation +created_by: hjd +creation_date: 2011-06-09T03:17:13Z + [Term] id: GO:0002200 name: somatic diversification of immune receptors @@ -44076,6 +44276,14 @@ def: "A circulatory process that occurs at the level of the vasculature." [GOC:m synonym: "vasculature process" EXACT [] is_a: GO:0003013 ! circulatory system process +[Term] +id: GO:0003032 +name: detection of oxygen +namespace: biological_process +def: "The series of events in which an oxygen stimulus is received by a cell and converted into a molecular signal." [GOC:mtg_cardio] +is_a: GO:0009593 ! detection of chemical stimulus +is_a: GO:0070482 ! response to oxygen levels + [Term] id: GO:0003044 name: regulation of systemic arterial blood pressure mediated by a chemical signal @@ -45813,7 +46021,7 @@ id: GO:0003382 name: epithelial cell morphogenesis namespace: biological_process def: "The change in form that occurs when an epithelial cell progresses from its initial formation to its mature state." [GOC:ascb_2009, GOC:dph, GOC:tb] -is_a: GO:0000904 ! cell morphogenesis involved in differentiation +is_a: GO:0000902 ! cell morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: results_in_maturation_of CL:0000066 ! epithelial cell relationship: part_of GO:0002064 ! epithelial cell development @@ -46228,11 +46436,10 @@ id: GO:0004672 name: protein kinase activity namespace: molecular_function alt_id: GO:0050222 -def: "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN] +def: "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [PMID:25399640] comment: Note that triphosphate is used as a phosphate donor by at least one kinase. subset: goslim_candida synonym: "protamine kinase activity" NARROW [] -xref: MetaCyc:PROTEIN-KINASE-RXN xref: Reactome:R-HSA-156832 "INF-gamma induced phosphorylation of L13a" xref: Reactome:R-HSA-937034 "IRAK1 phosphorylates Pellino" xref: Reactome:R-HSA-9604606 "Unknown kinase phosphorylates NICD4" @@ -46242,511 +46449,6 @@ is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor is_a: GO:0140096 ! catalytic activity, acting on a protein -[Term] -id: GO:0004674 -name: protein serine/threonine kinase activity -namespace: molecular_function -alt_id: GO:0004695 -alt_id: GO:0004696 -alt_id: GO:0004700 -alt_id: GO:0106311 -def: "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf, PMID:2956925] -synonym: "protein serine kinase activity" NARROW [EC:2.7.11.1] -synonym: "protein serine-threonine kinase activity" RELATED [EC:2.7.11.1] -synonym: "protein threonine kinase activity" NARROW [] -synonym: "protein-serine kinase activity" NARROW [EC:2.7.11.1] -synonym: "serine kinase activity" NARROW [EC:2.7.11.1] -synonym: "serine protein kinase activity" NARROW [EC:2.7.11.1] -synonym: "serine(threonine) protein kinase activity" RELATED [EC:2.7.11.1] -synonym: "serine-specific protein kinase activity" NARROW [EC:2.7.11.1] -synonym: "serine/threonine protein kinase activity" RELATED [EC:2.7.11.1] -synonym: "threonine-specific protein kinase activity" NARROW [EC:2.7.11.1] -xref: EC:2.7.11.1 {source="skos:exactMatch"} -xref: Reactome:R-HSA-109702 "PDPK1 phosphorylates AKT2" -xref: Reactome:R-HSA-109822 "MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1" -xref: Reactome:R-HSA-109823 "MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2" -xref: Reactome:R-HSA-109860 "MAP2K1 phosphorylates MAPK3" -xref: Reactome:R-HSA-109862 "MAP2K2 phosphorylates MAPK1" -xref: Reactome:R-HSA-111919 "PKA phosphorylates CREB1" -xref: Reactome:R-HSA-111970 "PKC phosphorylates GRK2" -xref: Reactome:R-HSA-112342 "Inactivation of MAP2K1 by CDK1" -xref: Reactome:R-HSA-112381 "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex" -xref: Reactome:R-HSA-1168635 "PRKCB (PKC-beta) phosphorylates CARMA1" -xref: Reactome:R-HSA-1168638 "Activated IKK phosphorylates I-kappaB" -xref: Reactome:R-HSA-1168641 "TAK1 associated with the CBM complex phosphorylates IKKbeta" -xref: Reactome:R-HSA-1181149 "ACVR2A,B (ActRIIA,B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin" -xref: Reactome:R-HSA-1181156 "Type II Activin Receptor (ActRII/ACVR2) phosphorylates Type I Activin Receptor (ActRIB/ACVR1B) in response to NODAL" -xref: Reactome:R-HSA-1181355 "Phosphorylation of R-SMAD2/3 by NODAL receptor" -xref: Reactome:R-HSA-1225894 "Type II Activin Receptor (ActRIIB/ACVR2B) phosphorylates Type I Activin Receptor (ActRIC/ACVR1C) in response to NODAL" -xref: Reactome:R-HSA-1358791 "Phosphorylation of USP8 by P-AKT" -xref: Reactome:R-HSA-1362270 "Phosphorylation of LIN52 component of MuvB by DYRK1A" -xref: Reactome:R-HSA-139908 "Phosphorylation of DLC2 by MAPK8" -xref: Reactome:R-HSA-139918 "Phosphorylation of BIM by JNK" -xref: Reactome:R-HSA-1445144 "p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4)" -xref: Reactome:R-HSA-1449597 "p-AKT2 phosphorylates Myosin 5A" -xref: Reactome:R-HSA-1454699 "AMPK-alpha2 phosphorylates TBC1D1" -xref: Reactome:R-HSA-1458463 "p-AKT2 phosphorylates RGC2" -xref: Reactome:R-HSA-1549526 "Phosphorylation of SMAD2,3 by Activin:Activin Receptor" -xref: Reactome:R-HSA-156673 "Regulation of KIF23 (MKLP1) by phosphorylation" -xref: Reactome:R-HSA-156678 "Activation of Cdc25C" -xref: Reactome:R-HSA-156682 "PLK1 phosphorylates NUDC" -xref: Reactome:R-HSA-156699 "Inactivation of Wee1 kinase" -xref: Reactome:R-HSA-156723 "Regulation of KIF20A (MKL2) by phosphorylation" -xref: Reactome:R-HSA-1592233 "p38 MAPK phosphorylates PPARGC1A" -xref: Reactome:R-HSA-162363 "p-T309,S474-AKT2:PIP3 phosphorylates PDE3B" -xref: Reactome:R-HSA-162657 "Inactivation of Myt1 kinase" -xref: Reactome:R-HSA-163010 "Down Regulation of Emi1 through Phosphorylation of Emi1" -xref: Reactome:R-HSA-1632857 "ULK1 phosphorylates AMBRA1:BECN1 complex" -xref: Reactome:R-HSA-163416 "hormone-sensitive lipase (HSL) + 2 ATP -> phosphorylated HSL + 2 ADP" -xref: Reactome:R-HSA-163418 "perilipin + 2 ATP -> phosphorylated perilipin + 2 ADP" -xref: Reactome:R-HSA-1638803 "Phosphorylation of cohesin by PLK1 at centromeres" -xref: Reactome:R-HSA-164151 "LKB1 phosphorylates the alpha subunit of AMPK heterotrimer" -xref: Reactome:R-HSA-165162 "Phosphorylation of TSC2 by PKB" -xref: Reactome:R-HSA-165182 "Phosphorylation of complexed TSC2 by PKB" -xref: Reactome:R-HSA-165692 "Phosphorylation of 4E-BP1 by activated mTORC1" -xref: Reactome:R-HSA-165718 "mTORC1 phosphorylation of RPS6KB1 (S6K)" -xref: Reactome:R-HSA-165726 "Phosphorylation of Ribosomal protein S6 by activated S6K1" -xref: Reactome:R-HSA-165758 "Phosphorylation and inactivation of eEF2K by activated S6K1" -xref: Reactome:R-HSA-165766 "Phosphorylation and activation of eIF4G by activated S6K1" -xref: Reactome:R-HSA-165777 "Phosphorylation and activation of eIF4B by activated S6K1" -xref: Reactome:R-HSA-166119 "First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal" -xref: Reactome:R-HSA-166245 "Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex" -xref: Reactome:R-HSA-166284 "Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:TIRAP" -xref: Reactome:R-HSA-166286 "Multiple IRAK1 autophosphorylation steps" -xref: Reactome:R-HSA-167084 "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex" -xref: Reactome:R-HSA-167098 "Phosphorylation (Ser5) of RNA pol II CTD" -xref: Reactome:R-HSA-168053 "Phosphorylated MAPKs phosphorylate ATF-2" -xref: Reactome:R-HSA-168140 "Active IKK Complex phosphorylates NF-kappa-B inhibitor" -xref: Reactome:R-HSA-168184 "Activated TAK1 mediates phosphorylation of the IKK Complex" -xref: Reactome:R-HSA-170055 "Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes" -xref: Reactome:R-HSA-170076 "CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes" -xref: Reactome:R-HSA-170087 "CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes" -xref: Reactome:R-HSA-170116 "Myt-1 mediated phosphorylation of Cyclin A:Cdc2" -xref: Reactome:R-HSA-170126 "Phosphorylation of Cyclin B1 in the CRS domain" -xref: Reactome:R-HSA-170977 "FRS2 is phosphorylated by active TrkA receptor" -xref: Reactome:R-HSA-174119 "Free APC/C phosphorylated by Plk1" -xref: Reactome:R-HSA-174174 "Phosphorylation of the Emi1 DSGxxS degron by Plk1" -xref: Reactome:R-HSA-176116 "Recruitment and activation of Chk1" -xref: Reactome:R-HSA-176298 "Activation of claspin" -xref: Reactome:R-HSA-187688 "p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3" -xref: Reactome:R-HSA-187949 "CAK-mediated phosphorylation of Cyclin A:Cdk2" -xref: Reactome:R-HSA-188350 "CAK-mediated phosphorylation of Cyclin E:Cdk2" -xref: Reactome:R-HSA-193647 "IRAK is activated" -xref: Reactome:R-HSA-193705 "IKKbeta phosphorylates IkB causing NF-kB to dissociate" -xref: Reactome:R-HSA-195275 "Phosphorylation of APC component of the destruction complex" -xref: Reactome:R-HSA-195283 "Phosphorylation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3" -xref: Reactome:R-HSA-195287 "Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3" -xref: Reactome:R-HSA-195300 "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3" -xref: Reactome:R-HSA-195318 "Phosphorylation of beta-catenin at Ser45 by CK1 alpha" -xref: Reactome:R-HSA-198270 "PDPK1 phosphorylates AKT at T308" -xref: Reactome:R-HSA-198347 "AKT phosphorylates BAD" -xref: Reactome:R-HSA-198371 "AKT phosphorylates GSK3" -xref: Reactome:R-HSA-198599 "AKT phosphorylates MDM2" -xref: Reactome:R-HSA-198609 "AKT phosphorylates TSC2, inhibiting it" -xref: Reactome:R-HSA-198611 "AKT phosphorylates IKKalpha" -xref: Reactome:R-HSA-198613 "AKT phosphorylates p21Cip1 and p27Kip1" -xref: Reactome:R-HSA-198621 "AKT phosphorylates caspase-9" -xref: Reactome:R-HSA-198640 "TORC2 (mTOR) phosphorylates AKT at S473" -xref: Reactome:R-HSA-198669 "p38MAPK phosphorylates MSK1" -xref: Reactome:R-HSA-198731 "ERK1/2 activates ELK1" -xref: Reactome:R-HSA-198746 "ERK1/2/5 activate RSK1/2/3" -xref: Reactome:R-HSA-198756 "ERK1/2 phosphorylates MSK1" -xref: Reactome:R-HSA-199298 "AKT phosphorylates CREB1" -xref: Reactome:R-HSA-199299 "AKT phosphorylates FOXO transcription factors" -xref: Reactome:R-HSA-199839 "AKT can phosphorylate RSK" -xref: Reactome:R-HSA-199863 "AKT can phosphorylate NR4A1 (NUR77)" -xref: Reactome:R-HSA-199895 "RSK1/2/3 phosphorylates CREB at Serine 133" -xref: Reactome:R-HSA-199910 "MSK1 activates ATF1" -xref: Reactome:R-HSA-199917 "MAPKAPK2 phosphorylates CREB at Serine 133" -xref: Reactome:R-HSA-199929 "ERK5 activates the transcription factor MEF2" -xref: Reactome:R-HSA-199935 "MSK1 activates CREB" -xref: Reactome:R-HSA-200143 "AKT phosphorylates AKT1S1 (PRAS40)" -xref: Reactome:R-HSA-200421 "Activation of cytosolic AMPK by phosphorylation" -xref: Reactome:R-HSA-201677 "Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta" -xref: Reactome:R-HSA-201691 "Phosphorylation of LRP5/6 cytoplasmic domain by CSNKI" -xref: Reactome:R-HSA-201717 "CSNK2-mediated phosphorylation of DVL" -xref: Reactome:R-HSA-202222 "Phosphorylation of PKC theta" -xref: Reactome:R-HSA-202437 "Phosphorylation of CARMA1" -xref: Reactome:R-HSA-202459 "Phosphorylation of Bcl10" -xref: Reactome:R-HSA-202500 "Activation of IKK complex" -xref: Reactome:R-HSA-202510 "Activation of TAK1-TAB2 complex" -xref: Reactome:R-HSA-202541 "p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB" -xref: Reactome:R-HSA-2028284 "Phosphorylation of STK4 (MST1) and SAV1 by STK4" -xref: Reactome:R-HSA-2028555 "Phosphorylation of LATS1 and 2 by p-STK4 (p-MST1)" -xref: Reactome:R-HSA-2028583 "Phosphorylation of YAP by LATS2" -xref: Reactome:R-HSA-2028589 "Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2)" -xref: Reactome:R-HSA-2028591 "Phosphorylation of STK3 (MST2) and SAV1 by STK3" -xref: Reactome:R-HSA-2028598 "Phosphorylation of YAP by LATS1" -xref: Reactome:R-HSA-2028629 "Phosphorylation of MOB1A and B by p-STK4 (p-MST1)" -xref: Reactome:R-HSA-2028635 "Phosphorylation of MOB1A and B by p-STK3 (p-MST2)" -xref: Reactome:R-HSA-2028661 "Phosphorylation of WWTR1 (TAZ) by LATS2" -xref: Reactome:R-HSA-2028670 "Phosphorylation of MOB1A and B by p-STK4(MST1)/N" -xref: Reactome:R-HSA-2028673 "Phosphorylation of LATS1 and 2 by p-STK3 (MST2)/N" -xref: Reactome:R-HSA-2028675 "Phosphorylation of MOB1A and B by p-STK3(MST2)/N" -xref: Reactome:R-HSA-2028679 "Phosphorylation of LATS1 and 2 by p-STK4(MST1)/N" -xref: Reactome:R-HSA-2029454 "Autophosphorylation of PAK1" -xref: Reactome:R-HSA-2029460 "PAK1 phosphorylates LIMK1" -xref: Reactome:R-HSA-2029469 "p-ERK phosphorylates WAVEs and ABI" -xref: Reactome:R-HSA-2060328 "Phosphorylation of WWTR1 (TAZ) by LATS1" -xref: Reactome:R-HSA-209087 "IKBA is phosphorylated by Phospho IKKB kinase" -xref: Reactome:R-HSA-211164 "AKT phosphorylates FOXO1A" -xref: Reactome:R-HSA-211583 "Partial autophosphorylation of PAK-2 at Ser-19, Ser-20, Ser-55, Ser-192, and Ser-197" -xref: Reactome:R-HSA-211650 "Autophosphorylation of PAK-2p34 in the activation loop" -xref: Reactome:R-HSA-2168079 "MASTL (GWL) phosphorylates ARPP19" -xref: Reactome:R-HSA-2176475 "Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9" -xref: Reactome:R-HSA-2214351 "PLK1 phosphorylates GORASP1" -xref: Reactome:R-HSA-2243938 "AKT1 E17K mutant is phosphorylated by TORC2 complex" -xref: Reactome:R-HSA-2243942 "PDPK1 phosphorylates AKT1 E17K mutant" -xref: Reactome:R-HSA-2294580 "PLK1 hyperphosphorylates Condensin II complex" -xref: Reactome:R-HSA-2396007 "IRF3 is phosphorylated by TBK1" -xref: Reactome:R-HSA-2399941 "AKT1 E17K mutant phosphorylates BAD" -xref: Reactome:R-HSA-2399966 "AKT1 E17K mutant phosphorylates GSK3" -xref: Reactome:R-HSA-2399969 "AKT1 E17K mutant phosphorylates p21Cip1 and p27Kip1" -xref: Reactome:R-HSA-2399977 "AKT1 E17K mutant phosphorylates AKT1S1 (PRAS40)" -xref: Reactome:R-HSA-2399981 "AKT1 E17K mutant phosphorylates MDM2" -xref: Reactome:R-HSA-2399982 "AKT1 E17K mutant phosphorylates TSC2, inhibiting it" -xref: Reactome:R-HSA-2399985 "AKT1 E17K mutant phosphorylates caspase-9" -xref: Reactome:R-HSA-2399988 "AKT1 E17K mutant phosphorylates NR4A1 (NUR77)" -xref: Reactome:R-HSA-2399992 "AKT1 E17K mutant phosphorylates forkhead box transcription factors" -xref: Reactome:R-HSA-2399996 "AKT1 E17K mutant phosphorylates CREB1" -xref: Reactome:R-HSA-2399999 "AKT1 E17K mutant phosphorylates RSK" -xref: Reactome:R-HSA-2400001 "AKT1 E17K mutant phosphorylates CHUK (IKKalpha)" -xref: Reactome:R-HSA-2422927 "MAPK3-3 or MAPK1 phosphorylate GORASP2" -xref: Reactome:R-HSA-2430535 "MASTL phosphorylates ENSA" -xref: Reactome:R-HSA-2466068 "Phosphorylation of cohesin by PLK1 at chromosomal arms" -xref: Reactome:R-HSA-2470508 "ACVR2A,B (ActRIIA,B) phosphorylates ACVR1C (ActRIC, ALK7) in response to Activin" -xref: Reactome:R-HSA-2529020 "CK2 phosphorylates condensin I subunits" -xref: Reactome:R-HSA-2562526 "PLK1 phosphorylates OPTN" -xref: Reactome:R-HSA-2574840 "AJUBA facilitates AURKA autophosphorylation" -xref: Reactome:R-HSA-2730856 "Autophosphorylation of PAK" -xref: Reactome:R-HSA-2730868 "Phosphorylation of MEK7 by MEKK1" -xref: Reactome:R-HSA-2730876 "Phosphorylation of IKK-beta by TAK1" -xref: Reactome:R-HSA-2730896 "Phosphorylation of MEK4 by MEKK1" -xref: Reactome:R-HSA-2730900 "Activation of TAK1 complex bound to pUb-TRAF6" -xref: Reactome:R-HSA-2984226 "PLK1 phosphorylates NEK9" -xref: Reactome:R-HSA-2984258 "NEK9 phosphorylates NEK6/NEK7" -xref: Reactome:R-HSA-2990880 "NEK6/NEK7 phosphorylates NUP98" -xref: Reactome:R-HSA-2993898 "VRK1/VRK2 phosphorylate BANF1" -xref: Reactome:R-HSA-3000310 "AURKA phosphorylates PLK1" -xref: Reactome:R-HSA-3000327 "PLK1 phosphorylates BORA" -xref: Reactome:R-HSA-3132737 "MAPKs phosphorylate ETS1 and ETS2" -xref: Reactome:R-HSA-3209160 "Activated ERKs phosphorylate ERF" -xref: Reactome:R-HSA-3222006 "STK11 (LKB1) phosphorylates NUAK1" -xref: Reactome:R-HSA-3222020 "NUAK1 phosphorylates TP53" -xref: Reactome:R-HSA-3228469 "MAP3K5 phosphorylates MKK3 and MKK6" -xref: Reactome:R-HSA-3229102 "p-MAPKAPK3 phosphorylates BMI1" -xref: Reactome:R-HSA-3229152 "MAP3K5 (ASK1) phosphorylates MAP2K4 (SEK1)" -xref: Reactome:R-HSA-3239014 "MAPKAPK5 phosphorylates TP53" -xref: Reactome:R-HSA-3239019 "Active p38 MAPK phosphorylates MAPKAPK5" -xref: Reactome:R-HSA-3249371 "TBK1 phosphorylates STAT6 at Ser407" -xref: Reactome:R-HSA-3371435 "Constitutive phosphorylation by GSK3" -xref: Reactome:R-HSA-3371531 "Constitutive phosphorylation by pERK1/2" -xref: Reactome:R-HSA-3371567 "DBC1 is phosphorylated by ATM/ART" -xref: Reactome:R-HSA-349426 "Phosphorylation of MDM4 by CHEK2" -xref: Reactome:R-HSA-349444 "Phosphorylation of COP1 at Ser-387 by ATM" -xref: Reactome:R-HSA-349455 "Phosphorylation of MDM4 by ATM" -xref: Reactome:R-HSA-374696 "Phosphorylation of L1 by p90rsk" -xref: Reactome:R-HSA-3769394 "AKT phosphorylates CBY1" -xref: Reactome:R-HSA-377186 "Activated Akt1 phosphorylates AKT1S1 (PRAS40)" -xref: Reactome:R-HSA-3772435 "WNT signaling stimulates CSNK1-dependent phosphorylation of DVL" -xref: Reactome:R-HSA-380272 "Plk1-mediated phosphorylation of Nlp" -xref: Reactome:R-HSA-381091 "IRE1 dimer autophosphorylates" -xref: Reactome:R-HSA-381111 "EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK" -xref: Reactome:R-HSA-3857328 "RPS6KA1/2/3 phosphorylates CEBPB on S321" -xref: Reactome:R-HSA-3857329 "MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB" -xref: Reactome:R-HSA-3858480 "WNT-dependent phosphorylation of DVL" -xref: Reactome:R-HSA-389756 "AKT interacts and phosphorylates Cot" -xref: Reactome:R-HSA-392752 "Phosphorylation of L1 by CK-II" -xref: Reactome:R-HSA-3928577 "ROCK phosphorylates LIMK1,2" -xref: Reactome:R-HSA-3928608 "LIMK phosphorylates CFL1, inactivating it" -xref: Reactome:R-HSA-3928616 "Activated ROCK phosphorylates MRLCs" -xref: Reactome:R-HSA-3928620 "PAK1 autophosphorylates" -xref: Reactome:R-HSA-3928625 "PAKs autophosphorylate" -xref: Reactome:R-HSA-3928640 "PAKs phosphorylate MLC" -xref: Reactome:R-HSA-399939 "Autophosphorylation of PAK" -xref: Reactome:R-HSA-399944 "Phosphorylation of CRMPs by Cdk5" -xref: Reactome:R-HSA-399950 "Phosphorylation of cofilin by LIMK-1" -xref: Reactome:R-HSA-399951 "Phosphorylation of CRMPs by GSK3beta" -xref: Reactome:R-HSA-399952 "Phosphorylation of LIMK-1 by PAK" -xref: Reactome:R-HSA-399978 "Protein kinase C, alpha type phosphorylates MARCKS" -xref: Reactome:R-HSA-400382 "CSNK1E,CSNK1D phosphorylate CRY and PER proteins" -xref: Reactome:R-HSA-4088134 "PLK1 phosphorylates FOXM1" -xref: Reactome:R-HSA-419083 "Myosin phosphatase inactivation by ROCK" -xref: Reactome:R-HSA-419087 "LIM kinase phosphorylation by ROCK" -xref: Reactome:R-HSA-419197 "Myosin regulatory light chain phosphorylation by ROCK" -xref: Reactome:R-HSA-419644 "Transphosphorylation of pLIMK1" -xref: Reactome:R-HSA-428961 "Phosphorylation of cPLA2 by MAPK p38 alpha" -xref: Reactome:R-HSA-429016 "ALOX5 is phosphorylated by MAPKAP2" -xref: Reactome:R-HSA-429714 "monophospho-CERT + 2 ATP => multiphospho-CERT + 2 ADP" -xref: Reactome:R-HSA-432110 "Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding" -xref: Reactome:R-HSA-4332358 "Dissociation of CaM and CAMK2 autophosphorylation" -xref: Reactome:R-HSA-4332363 "Autophosphorylation and activation of CAMK2" -xref: Reactome:R-HSA-4332388 "Activation of MAP3K7 in response to WNT" -xref: Reactome:R-HSA-4411383 "NLK phosphorylates TCF/LEF" -xref: Reactome:R-HSA-4411402 "Activation of NLK" -xref: Reactome:R-HSA-442724 "Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs)" -xref: Reactome:R-HSA-442739 "PDPK1 phosphorylates RSKs" -xref: Reactome:R-HSA-442832 "PAK phosphorylates cortactin" -xref: Reactome:R-HSA-445072 "Interaction of PAK1 with Rac1-GTP" -xref: Reactome:R-HSA-446694 "IRAK4 phosphorylates IRAK1" -xref: Reactome:R-HSA-446701 "IRAK4-activated IRAK1 autophosphorylates" -xref: Reactome:R-HSA-448948 "Phosphorylation of E proteins by p38 MAPK" -xref: Reactome:R-HSA-448955 "Phosphorylation of MEF2 proteins by p38" -xref: Reactome:R-HSA-450222 "Active p38 MAPK phosphorylates MAPKAPK2 or 3" -xref: Reactome:R-HSA-450325 "c-FOS activation by phospho ERK1/2" -xref: Reactome:R-HSA-450337 "Activated TAK1 phosphorylates MKK4/MKK7" -xref: Reactome:R-HSA-450346 "activated human TAK1 phosphorylates MKK3/MKK6" -xref: Reactome:R-HSA-450463 "MK2 phosphorylates ZFP36 (Tristetraproline, TTP)" -xref: Reactome:R-HSA-450474 "MK2 phosphorylates BRF1" -xref: Reactome:R-HSA-450490 "Protein Kinase B/Akt phosphorylates BRF1" -xref: Reactome:R-HSA-450499 "Protein Kinase B (AKT) phosphorylates KSRP" -xref: Reactome:R-HSA-450827 "hp-IRAK1, hp-IRAK4 4 phosphorylate Pellino-1 and 2." -xref: Reactome:R-HSA-451152 "MAP kinase p38 phosphorylates KSRP" -xref: Reactome:R-HSA-451347 "Activation of JNK by DSCAM" -xref: Reactome:R-HSA-4551570 "VANGL2 is phosphorylated in response to WNT5A" -xref: Reactome:R-HSA-4608825 "DVL2 is phosphorylated after WNT5A binding to FZD" -xref: Reactome:R-HSA-4793911 "MAPKAPK2 phosphorylates HSF1" -xref: Reactome:R-HSA-5082387 "Phosphorylation of HSF1 at Ser230 induces transactivation" -xref: Reactome:R-HSA-5082405 "Phosphorylation of HSF1 at Ser326 induces transactivation" -xref: Reactome:R-HSA-5213464 "RIPK1 is phosphorylated" -xref: Reactome:R-HSA-5213466 "RIPK3 is phosphorylated" -xref: Reactome:R-HSA-5218814 "PAK2 autophorylates" -xref: Reactome:R-HSA-5218821 "PDK1 phosphorylates PKC" -xref: Reactome:R-HSA-5218826 "Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732" -xref: Reactome:R-HSA-5218854 "p-Y420-FYN is phosphorylated on S21" -xref: Reactome:R-HSA-5218906 "RIPK3 phosphorylates MLKL" -xref: Reactome:R-HSA-5218916 "p-MAPK2/3 phosphorylates HSP27" -xref: Reactome:R-HSA-5228811 "NFKBIA variant is not phosphorylated within IkBA:NF-kappaB" -xref: Reactome:R-HSA-5229343 "AXIN is phosphorylated in the destruction complex" -xref: Reactome:R-HSA-5260201 "p-AKT2 phosphorylates C2CD5" -xref: Reactome:R-HSA-5357472 "PAK1-3 autophosphorylates" -xref: Reactome:R-HSA-5357477 "PAK1-3 phosphorylates VE-cadherin" -xref: Reactome:R-HSA-5357831 "CHUK, IKBKB phosphorylate CYLD at S418" -xref: Reactome:R-HSA-5578777 "DMPK phosphorylates PLN" -xref: Reactome:R-HSA-5607722 "Active NIK phosphorylates IKKA dimer" -xref: Reactome:R-HSA-5607726 "Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB" -xref: Reactome:R-HSA-5607732 "K63polyUb-TAK1 autophosphorylates" -xref: Reactome:R-HSA-5607742 "K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta" -xref: Reactome:R-HSA-5610718 "CK1 phosphorylates p-GLI2" -xref: Reactome:R-HSA-5610722 "CK1 phosphorylates p-GLI3" -xref: Reactome:R-HSA-5610730 "GSK3 phosphorylates p-GLI2" -xref: Reactome:R-HSA-5610732 "GSK3 phosphorylates p-GLI3" -xref: Reactome:R-HSA-5624473 "Protein kinase A (PKA) and RPS6KA5 (MSK1) phosphorylates p65 (RELA) subunit" -xref: Reactome:R-HSA-5624492 "PAK phosphorylates p21 RAF1 on S338" -xref: Reactome:R-HSA-5627775 "Autophosphorylation of PAK1,2,3" -xref: Reactome:R-HSA-5632670 "CSNK1A1 phosphorylates SMO dimer" -xref: Reactome:R-HSA-5632672 "ADRBK1 phosphorylates SMO dimer" -xref: Reactome:R-HSA-5635841 "GLI proteins are phosphorylated" -xref: Reactome:R-HSA-5635842 "ULK3 phosphorylates GLI" -xref: Reactome:R-HSA-5665868 "AMPK (complex) phosphorylates ULK1 (complex)" -xref: Reactome:R-HSA-5666160 "AURKB phosphorylates DIAPH2-2 at kinetochores" -xref: Reactome:R-HSA-5668545 "NIK autophosphorylates on T559" -xref: Reactome:R-HSA-5668932 "PAK2 phosphorylates myosin regulatory light chain (MRLC)" -xref: Reactome:R-HSA-5668947 "PAK1 phosphorylates myosin phosphatase" -xref: Reactome:R-HSA-5668984 "PAK1 or PAK2 phosphorylates MYLK" -xref: Reactome:R-HSA-5669250 "PAK1 phosphorylates FLNA" -xref: Reactome:R-HSA-5671763 "p-T774-PKN1 phosphorylates PPP1R14A" -xref: Reactome:R-HSA-5671919 "Activated CIT phosphorylates MRLCs" -xref: Reactome:R-HSA-5672008 "Thr-180 of ULK1 is phosphorylated" -xref: Reactome:R-HSA-5672010 "Active MTORC1 phosphorylates ULK1" -xref: Reactome:R-HSA-5672828 "mTORC1 phosphorylates AKT1S1" -xref: Reactome:R-HSA-5672948 "MARK3 phosphorylates KSR1" -xref: Reactome:R-HSA-5672973 "MAP2Ks phosphorylate MAPKs" -xref: Reactome:R-HSA-5672978 "RAF phosphorylates MAP2K dimer" -xref: Reactome:R-HSA-5674496 "Activated MAPKs phosphorylate MAP2K1" -xref: Reactome:R-HSA-5675194 "Activated MAPK phosphorylates RAF1" -xref: Reactome:R-HSA-5675198 "Activated MAPKs phosphorylate BRAF" -xref: Reactome:R-HSA-5675868 "ULK1 phosphorylates ATG13 and RB1CC1" -xref: Reactome:R-HSA-5679205 "ULK1 phosphorylates Beclin-1" -xref: Reactome:R-HSA-5682026 "MRN bound to shortened telomeres activates ATM" -xref: Reactome:R-HSA-5682101 "PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer" -xref: Reactome:R-HSA-5682598 "ATM phosphorylates HERC2" -xref: Reactome:R-HSA-5682983 "ATM phosphorylates WHSC1" -xref: Reactome:R-HSA-5683425 "ATM phosphorylates TP53BP1 at DNA DSBs" -xref: Reactome:R-HSA-5683792 "p-T68-CHEK2 autophosphorylates" -xref: Reactome:R-HSA-5683801 "CHEK2 phosphorylates BRCA1" -xref: Reactome:R-HSA-5683964 "ATM phosphorylates EYA1-4" -xref: Reactome:R-HSA-5684096 "CDK2 phosphorylates RBBP8" -xref: Reactome:R-HSA-5684140 "ATM phosphorylates RBBP8" -xref: Reactome:R-HSA-5684887 "Activation of CHEK1 at resected DNA DSBs" -xref: Reactome:R-HSA-5685156 "ATR phosphorylates RPA2" -xref: Reactome:R-HSA-5685230 "CHEK1 phosphorylates RAD51" -xref: Reactome:R-HSA-5685242 "CHEK1 phosphorylates BRCA2" -xref: Reactome:R-HSA-5686578 "Activated ATM phosphorylates ABL1" -xref: Reactome:R-HSA-5686704 "Activated ATM phosphorylates DCLRE1C" -xref: Reactome:R-HSA-5687086 "PAK1,2,3 phosphorylates MAPK6,4" -xref: Reactome:R-HSA-5687090 "p-S MAPK6 phosphorylates NCOA3" -xref: Reactome:R-HSA-5687094 "p-S MAPK6,4 phosphorylate MAPKAPK5" -xref: Reactome:R-HSA-5687101 "p-T182 MAPKAPK5 phosphorylates FOXO3" -xref: Reactome:R-HSA-5687121 "p-S MAPKAPK5 phosphorylates HSPB1" -xref: Reactome:R-HSA-5687183 "PRKDC phosphorylates DCLRE1C at DNA DSBs" -xref: Reactome:R-HSA-5690250 "p-T182-MAPKAPK5 phoshphorylates DNAJB1" -xref: Reactome:R-HSA-5692768 "MAPKAPK5 phosphorylates KALRN" -xref: Reactome:R-HSA-5692775 "SEPT7:p-S189 MAPK6:p-T182 MAPKAPK5 phosphorylates CDC42EPs" -xref: Reactome:R-HSA-5692779 "p-S182 MAPKAPK5 phosphorylates FOXO1" -xref: Reactome:R-HSA-5693536 "ATM phosphorylates MDC1" -xref: Reactome:R-HSA-5693540 "MRN activates ATM" -xref: Reactome:R-HSA-5693549 "ATM phosphorylates histone H2AFX on S139 at DNA DSBs" -xref: Reactome:R-HSA-5693551 "Phosphorylation of BRCA1-A complex at multiple sites by ATM" -xref: Reactome:R-HSA-5693575 "DNA-PKcs autophosphorylates" -xref: Reactome:R-HSA-5693598 "ATM phosphorylates NBN" -xref: Reactome:R-HSA-5693609 "ATM phosphorylates TP53 at S15" -xref: Reactome:R-HSA-5694441 "CSNK1D phosphorylates SEC23" -xref: Reactome:R-HSA-6788392 "ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA" -xref: Reactome:R-HSA-6795290 "TORC2 complex phosphorylates SGK1" -xref: Reactome:R-HSA-6795460 "SGK1 phosphorylates MDM2" -xref: Reactome:R-HSA-6795473 "PDPK1 phosphorylates SGK1" -xref: Reactome:R-HSA-6798372 "ATM phosphorylates DYRK2" -xref: Reactome:R-HSA-6798374 "DYRK2 phosphorylates TP53" -xref: Reactome:R-HSA-6799097 "ATM phosphorylates ZNF420" -xref: Reactome:R-HSA-6799246 "CHEK1 phosphorylates TP53" -xref: Reactome:R-HSA-6799332 "ATR phosphorylates TP53" -xref: Reactome:R-HSA-6799409 "HIPK2 phosphorylates TP53" -xref: Reactome:R-HSA-6800490 "ATM phosphorylates PIDD1" -xref: Reactome:R-HSA-6801666 "PLK2 phosphorylates CENPJ" -xref: Reactome:R-HSA-6801675 "PLK2 phosphorylates NPM1" -xref: Reactome:R-HSA-6802911 "High kinase activity BRAF complexes phosphorylate MAP2Ks" -xref: Reactome:R-HSA-6802919 "RAS:GTP:moderate kinase activity p-RAF complexes phosphorylate MAP2Ks" -xref: Reactome:R-HSA-6802926 "Mutant RAS:p-RAF complexes phosphorylate MAP2Ks" -xref: Reactome:R-HSA-6802933 "p-BRAF and RAF fusion dimers phosphorylate MAP2Ks" -xref: Reactome:R-HSA-6802935 "MAPKs are phosphorylated downstream of BRAF and RAF fusion dimers" -xref: Reactome:R-HSA-6802943 "RAS:GTP:inactive p-RAF complexes phosphorylate MAP2Ks" -xref: Reactome:R-HSA-6802973 "PLK3 phosphorylates CDC25C" -xref: Reactome:R-HSA-6804266 "CHEK2 phosphorylates TTC5" -xref: Reactome:R-HSA-6804276 "ATM phosphorylates TTC5" -xref: Reactome:R-HSA-6804955 "ATM phosphorylates MDM2" -xref: Reactome:R-HSA-6805059 "CK2:FACT phosphorylates TP53" -xref: Reactome:R-HSA-6805103 "AURKA phosphorylates TP53" -xref: Reactome:R-HSA-6805126 "AURKB phosphorylates TP53" -xref: Reactome:R-HSA-6805276 "CDK5 phosphorylates TP53" -xref: Reactome:R-HSA-6805285 "PLK3 phosphorylates TP53" -xref: Reactome:R-HSA-6805399 "TAF1 phosphorylates TP53" -xref: Reactome:R-HSA-6805479 "TP53RK phosphorylates TP53" -xref: Reactome:R-HSA-6805640 "AKT phosphorylates KAT6A" -xref: Reactome:R-HSA-6805785 "AKT phosphorylates PHF20" -xref: Reactome:R-HSA-6810233 "CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter" -xref: Reactome:R-HSA-6811454 "MAPKs phosphorylate PP2A" -xref: Reactome:R-HSA-6814409 "CK2 phosphorylates PDCL" -xref: Reactome:R-HSA-69604 "Phosphorylation of Cdc25A at Ser-123 by Chk1" -xref: Reactome:R-HSA-69608 "Phosphorylation of Cdc25A at Ser-123 by Chk2" -xref: Reactome:R-HSA-69685 "CHEK2 phosphorylates TP53" -xref: Reactome:R-HSA-69891 "Phosphorylation and activation of CHEK2 by ATM" -xref: Reactome:R-HSA-75010 "Phosphorylation of Cdc25C at Ser 216 by Chk1" -xref: Reactome:R-HSA-75028 "Phosphorylation of Wee1 kinase by Chk1" -xref: Reactome:R-HSA-75809 "Phosphorylation of Cdc25C at Ser216 by CHEK2" -xref: Reactome:R-HSA-75820 "Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta" -xref: Reactome:R-HSA-77071 "Phosphorylation (Ser5) of RNA pol II CTD" -xref: Reactome:R-HSA-8850945 "Casein kinase II phosphorylates PTEN" -xref: Reactome:R-HSA-8852306 "Mitotic phosphorylation-induced dissociation of GTSE1 from microtubule plus ends" -xref: Reactome:R-HSA-8852317 "PLK1 phosphorylates GTSE1" -xref: Reactome:R-HSA-8853419 "TPX2 promotes AURKA autophosphorylation" -xref: Reactome:R-HSA-8853444 "AURKA phosphorylates PHLDA1" -xref: Reactome:R-HSA-8854908 "PKA phosphorylates RET:GDNF:GFRA dimer" -xref: Reactome:R-HSA-8856813 "AAK1 phosphorylates AP-2 mu subunit at T156" -xref: Reactome:R-HSA-8863007 "p25-bound CDK5 phosphorylates CDC25B" -xref: Reactome:R-HSA-8863011 "p25-bound CDK5 phosphorylates CDC25C" -xref: Reactome:R-HSA-8863014 "p25-bound CDK5 phosphorylates CDC25A" -xref: Reactome:R-HSA-8863895 "IKKB phosphorylates SNAP23" -xref: Reactome:R-HSA-8868118 "MAPK12 phosphorylates PTPN3" -xref: Reactome:R-HSA-8868260 "CDK5:p25 phosphorylates GOLGA2" -xref: Reactome:R-HSA-8868340 "CDK5:p25 phosphorylates lamin B1" -xref: Reactome:R-HSA-8868344 "CDK5:p25 phosphorylates lamin A" -xref: Reactome:R-HSA-8868567 "CDK5:p25 phosphorylates PRDX1" -xref: Reactome:R-HSA-8868573 "CDK5:p25 phosphorylates PRDX2" -xref: Reactome:R-HSA-8868666 "CDK5:p25 phosphorylates JUN" -xref: Reactome:R-HSA-8870558 "CDK5:p25 phosphorylates FOXO3" -xref: Reactome:R-HSA-8873929 "Casein kinase II phosphorylates STARD10" -xref: Reactome:R-HSA-8876446 "p-ULK1 phosphorylates DENND3" -xref: Reactome:R-HSA-8877691 "MAP2K6 phosphorylates PIP4K2B" -xref: Reactome:R-HSA-8878050 "HIPK2 phosphorylates RUNX1 and EP300" -xref: Reactome:R-HSA-8878054 "HIPK2 phosphorylates RUNX1" -xref: Reactome:R-HSA-8932322 "CK2 phosphorylates NFE2L2" -xref: Reactome:R-HSA-8933446 "Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling" -xref: Reactome:R-HSA-8939963 "Activated AKT phosphorylates RUNX2" -xref: Reactome:R-HSA-8940100 "CDK1 phosphorylates VCPIP1" -xref: Reactome:R-HSA-8942836 "CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6" -xref: Reactome:R-HSA-8944454 "mTORC1 phosphorylates MAF1" -xref: Reactome:R-HSA-8948039 "FUNDC1 is phosphorylated by CK2" -xref: Reactome:R-HSA-8948146 "FUNDC1 is phosphorylated by ULK1 at Ser17" -xref: Reactome:R-HSA-8948757 "AKT phosphorylates MKRN1" -xref: Reactome:R-HSA-8952289 "FAM20C phosphorylates FAM20C substrates" -xref: Reactome:R-HSA-9007539 "CHEK1 phosphorylates E2F6" -xref: Reactome:R-HSA-9008480 "GSK3B phosphorylates RUNX2" -xref: Reactome:R-HSA-9008822 "PPM1D dephosphorylates RUNX2" -xref: Reactome:R-HSA-9009208 "Activated ERKs phosphorylate RUNX2" -xref: Reactome:R-HSA-9012319 "p-TEFb phosphorylates serine 2 in RNA polymerase II CTD" -xref: Reactome:R-HSA-9013978 "Phosphorylation of IRF-3/IRF7 and their release from the activated TLR3 complex" -xref: Reactome:R-HSA-9022314 "HIPK2 phosphorylates MECP2" -xref: Reactome:R-HSA-9023132 "AURKB phosphorylates MECP2 at S423" -xref: Reactome:R-HSA-9032751 "Estrogen-independent phosphorylation of ESR1 S118 by MAPK1 and MAPK3" -xref: Reactome:R-HSA-9032863 "CDK5 phosphorylates NTRK2" -xref: Reactome:R-HSA-912470 "ATR phosphorylates Histone H2A.X at unsynapsed regions" -xref: Reactome:R-HSA-913996 "PKA/PKG phosphorylate Rap1GAP2" -xref: Reactome:R-HSA-918229 "Phosphorylation and release of IRF3/IRF7" -xref: Reactome:R-HSA-933525 "Phosphorylation and release of IRF7" -xref: Reactome:R-HSA-934559 "SPRY2 is phosphorylated by phosphorylated MNK1" -xref: Reactome:R-HSA-936951 "Activation of TAK1 complex bound to activated TLR4 complex" -xref: Reactome:R-HSA-937022 "IRAK4 autophosphorylation in the complex with activated TLR:MyD88:TIRAP" -xref: Reactome:R-HSA-937059 "Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:TIRAP:activated TLR complex" -xref: Reactome:R-HSA-9604328 "AKT1 phosphorylates NOTCH4" -xref: Reactome:R-HSA-9610153 "Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF" -xref: Reactome:R-HSA-9610156 "MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF" -xref: Reactome:R-HSA-9610163 "BRAF autophosphorylates downstream of RAP1 and NGF" -xref: Reactome:R-HSA-9612501 "SGK phosphorylates CREB1" -xref: Reactome:R-HSA-9612509 "SGK phosphorylates SRF" -xref: Reactome:R-HSA-9612980 "BRAF in Rap1-GTP complex:BRAF complex autophosphorylates" -xref: Reactome:R-HSA-9613530 "PRKAA2 phosphorylates PLINs" -xref: Reactome:R-HSA-9619515 "AMPK phosphorylates MAPT" -xref: Reactome:R-HSA-9619843 "ERKs phosphorylate RSKs" -xref: Reactome:R-HSA-9620004 "RSKs autophosphorylate" -xref: Reactome:R-HSA-9624526 "AKT phosphorylates FOXO3 downstream of ESR1 and EGFR" -xref: Reactome:R-HSA-9626880 "MAPK11 or MAPK14 phosphorylates NCF1 at Ser345" -xref: Reactome:R-HSA-9627089 "CASP9 is phosphorylated at T125" -xref: Reactome:R-HSA-9632868 "CDKN1B is phosphorylated in response to estrogen" -xref: Reactome:R-HSA-9633008 "p-T899-EIF2AK4 (GCN2) phosphorylates EIF2AS1" -xref: Reactome:R-HSA-9633742 "EIF2AK4 (GCN2) dimer autophosphorylates" -xref: Reactome:R-HSA-9634702 "LINC01139 promotes phosphorylation of HIF1A by LRRK2" -xref: Reactome:R-HSA-9645535 "ALPK1 phosphorylates TIFA" -xref: Reactome:R-HSA-9648089 "NEK6 and NEK7 phosphorylate EML4" -xref: Reactome:R-HSA-9648883 "p-T-EIF2AK1:ferriheme dimer autophosphorylates" -xref: Reactome:R-HSA-9648888 "p-T,T486,T488-EIF2AK1 phosphorylates EIF2S1 (eIF2-alpha)" -xref: Reactome:R-HSA-9652165 "MAP2K mutants constitutively phosphorylate MAPKs" -xref: Reactome:R-HSA-9653503 "KRAS4B is phosphorylated on serine 181" -xref: Reactome:R-HSA-9656214 "MAP2Ks phosphorylate MAPKs downstream of RAF1 mutants" -xref: Reactome:R-HSA-9656215 "RAF1 mutant complexes phosphorylate MAP2K dimer" -xref: Reactome:R-HSA-9662823 "PLK2, MAPK14 phosphorylate ADAM17" -xref: Reactome:R-HSA-9673346 "Unknown kinase phosphorylates p-DVL" -xref: Reactome:R-HSA-9683664 "GSK3 phosphorylates Nucleoprotein" -xref: Reactome:R-HSA-9699579 "AKT phosphorylates FOXO3 downstream of FLT3" -xref: Reactome:R-HSA-9705320 "TBK1, IKBKE are autophosphorylated at Ser172" -xref: Reactome:R-HSA-9705323 "Phosphorylation of TBK1/IKBKE" -xref: Reactome:R-HSA-9725030 "MAPK1 phsophorylates ZC3HCF1 in a NPM-ALK-dependent manner" -xref: Reactome:R-HSA-9729260 "GSK3 phosphorylates nucleoprotein" -xref: Reactome:R-HSA-9729300 "Unknown kinase phosphorylates nucleoprotein" -xref: Reactome:R-HSA-9729318 "CSNK1A1 phosphorylates nucleoprotein" -xref: Reactome:R-HSA-9731111 "MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3" -xref: Reactome:R-HSA-975125 "Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9" -xref: Reactome:R-HSA-975134 "Second phosphorylation of IRAK1 by IRAK4 bound to MyD88: activated TLR 7/8 or 9" -xref: Reactome:R-HSA-975160 "Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:activated TLR 7/8 or 9" -xref: Reactome:R-HSA-975170 "IRAK4 autophosphorylation in the complex with MyD88:activated TLR 7/8 or 9" -xref: Reactome:R-HSA-975180 "First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9" -xref: Reactome:R-HSA-9758486 "Unknown kinase phosphorylates 9b" -xref: Reactome:R-HSA-975853 "Multiple IRAK1 autophosphorylation within the complex p-IRAK4:oligo MyD88:activated TLR" -xref: Reactome:R-HSA-975861 "Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomerl:activated TLR5 or 10 complex" -xref: Reactome:R-HSA-975865 "IRAK4 autophosphorylation within the complex activated TLR:MyD88" -xref: Reactome:R-HSA-975874 "Second phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR complex" -xref: Reactome:R-HSA-975878 "First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR" -xref: Reactome:R-HSA-9762094 "GSK3B phosphorylates p-NFE2L2" -xref: Reactome:R-HSA-9766532 "SQSTM1 oligomer is phosphorylated" -xref: Reactome:R-HSA-9769115 "MAPK1,(MAPK3) phosphorylates NPAS4" -xref: Reactome:R-HSA-9773803 "Active IKBKB phosphorylates NF-kappa-B inhibitor" -xref: Reactome:R-HSA-9815501 "MAPKAPK2 phosphorylates RIPK1 at S320" -xref: Reactome:R-HSA-9817397 "TBK1, IKBKE phosphorylate RIPK1 at T189" -xref: Reactome:R-HSA-9818789 "CHUK, IKBKB phosphorylate RIPK1 at S25" -xref: Reactome:R-HSA-9819106 "ULK1 phosphorylates RIPK1 at S357" -is_a: GO:0004672 ! protein kinase activity -property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/20114" xsd:anyURI - [Term] id: GO:0004713 name: protein tyrosine kinase activity @@ -47537,6 +47239,14 @@ intersection_of: GO:0015267 ! channel activity intersection_of: has_primary_input CHEBI:24867 property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/24479" xsd:anyURI +[Term] +id: GO:0005217 +name: intracellular ligand-gated monoatomic ion channel activity +namespace: molecular_function +def: "Enables the transmembrane transfer of an ion by a channel that opens when a specific intracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] +synonym: "intracellular ligand-gated ion channel activity" BROAD [] +is_a: GO:0015276 ! ligand-gated monoatomic ion channel activity + [Term] id: GO:0005227 name: calcium activated cation channel activity @@ -48093,6 +47803,7 @@ xref: NIF_Subcellular:sao1702920020 xref: Wikipedia:Cell_nucleus is_a: GO:0043231 ! intracellular membrane-bounded organelle disjoint_from: GO:0005737 ! cytoplasm +disjoint_from: GO:0005829 ! cytosol relationship: in_taxon NCBITaxon:2759 {all_only="true"} ! Eukaryota relationship: only_in_taxon NCBITaxon:2759 ! Eukaryota @@ -48256,17 +47967,6 @@ intersection_of: GO:0031974 ! membrane-enclosed lumen intersection_of: part_of GO:0005773 ! vacuole relationship: part_of GO:0005773 ! vacuole -[Term] -id: GO:0005776 -name: autophagosome -namespace: cellular_component -def: "A double-membrane-bounded compartment that engulfs endogenous cellular material as well as invading microorganisms to target them to the lytic vacuole/lysosome for degradation as part of macroautophagy." [GOC:autophagy, ISBN:0198547684, PMID:11099404] -synonym: "autophagic vacuole" EXACT [NIF_Subcellular:sao8663416959] -synonym: "initial autophagic vacuole" RELATED [NIF_Subcellular:sao8663416959] -xref: NIF_Subcellular:sao8663416959 -is_a: GO:0005773 ! vacuole -relationship: capable_of_part_of GO:0016236 ! macroautophagy - [Term] id: GO:0005794 name: Golgi apparatus @@ -48304,6 +48004,23 @@ synonym: "vesicular component" RELATED [NIF_Subcellular:sao138219748] xref: NIF_Subcellular:sao819927218 is_a: GO:0031410 ! cytoplasmic vesicle +[Term] +id: GO:0005829 +name: cytosol +namespace: cellular_component +def: "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] +subset: goslim_agr +subset: goslim_chembl +subset: goslim_drosophila +subset: goslim_flybase_ribbon +subset: goslim_generic +subset: goslim_mouse +subset: goslim_plant +xref: NIF_Subcellular:sao101633890 +xref: Wikipedia:Cytosol +is_a: GO:0110165 ! cellular anatomical entity +relationship: part_of GO:0005737 ! cytoplasm + [Term] id: GO:0005840 name: ribosome @@ -49011,6 +48728,39 @@ synonym: "establishment and maintenance of RNA localization" EXACT [] synonym: "RNA localisation" EXACT [GOC:mah] is_a: GO:0033036 ! macromolecule localization +[Term] +id: GO:0006404 +name: RNA import into nucleus +namespace: biological_process +def: "The import of RNA from the cytoplasm to the nucleus." [GOC:ma] +synonym: "RNA import into cell nucleus" EXACT [] +synonym: "RNA transport from cytoplasm to nucleus" EXACT [] +synonym: "RNA-nucleus import" EXACT [] +is_a: GO:0050658 ! RNA transport +is_a: GO:0051170 ! import into nucleus +intersection_of: GO:0006810 ! transport +intersection_of: has_primary_input CHEBI:33697 +intersection_of: has_target_end_location GO:0031981 ! nuclear lumen +intersection_of: has_target_start_location GO:0005829 ! cytosol +intersection_of: results_in_transport_across GO:0005635 ! nuclear envelope + +[Term] +id: GO:0006405 +name: RNA export from nucleus +namespace: biological_process +def: "The directed movement of RNA from the nucleus to the cytoplasm." [GOC:ma] +synonym: "RNA export from cell nucleus" EXACT [] +synonym: "RNA export out of nucleus" EXACT [] +synonym: "RNA transport from nucleus to cytoplasm" EXACT [] +synonym: "RNA-nucleus export" EXACT [] +is_a: GO:0050658 ! RNA transport +is_a: GO:0051168 ! nuclear export +intersection_of: GO:0006810 ! transport +intersection_of: has_primary_input CHEBI:33697 +intersection_of: has_target_end_location GO:0005829 ! cytosol +intersection_of: has_target_start_location GO:0031981 ! nuclear lumen +intersection_of: results_in_transport_across GO:0005635 ! nuclear envelope + [Term] id: GO:0006412 name: translation @@ -49097,7 +48847,6 @@ synonym: "regulation of protein anabolism" EXACT [] synonym: "regulation of protein biosynthesis" EXACT [] synonym: "regulation of protein formation" EXACT [] synonym: "regulation of protein synthesis" EXACT [] -is_a: GO:0010556 ! regulation of macromolecule biosynthetic process is_a: GO:0010608 ! post-transcriptional regulation of gene expression is_a: GO:0051246 ! regulation of protein metabolic process intersection_of: GO:0065007 ! biological regulation @@ -49110,7 +48859,6 @@ name: regulation of translational initiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of translational initiation." [GOC:go_curators] is_a: GO:0006417 ! regulation of translation -is_a: GO:0031323 ! regulation of cellular metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0006413 ! translational initiation relationship: regulates GO:0006413 ! translational initiation @@ -49401,6 +49149,44 @@ def: "The formation of either of the compounds secreted by the thyroid gland, ma comment: Note that this term does not fall under the general GO definition for biosynthetic processes, which is 'The chemical reactions and pathways resulting in the formation of... ', because thyroid hormones can only be formed by the proteolysis of a larger molecule (see term definition). The word 'generation' is therefore used in place of biosynthesis. is_a: GO:0042403 ! thyroid hormone metabolic process +[Term] +id: GO:0006606 +name: protein import into nucleus +namespace: biological_process +def: "The directed movement of a protein from the cytoplasm to the nucleus." [GOC:jl] +synonym: "establishment of protein localization to nucleus" EXACT [GOC:mah] +synonym: "protein import into cell nucleus" EXACT [] +synonym: "protein nucleus import" EXACT [] +synonym: "protein transport from cytoplasm to nucleus" EXACT [] +is_a: GO:0006886 ! intracellular protein transport +is_a: GO:0034504 ! protein localization to nucleus +is_a: GO:0051170 ! import into nucleus +is_a: GO:0072594 ! establishment of protein localization to organelle +intersection_of: GO:0006810 ! transport +intersection_of: has_primary_input PR:000000001 ! protein +intersection_of: has_target_end_location GO:0031981 ! nuclear lumen +intersection_of: has_target_start_location GO:0005829 ! cytosol +intersection_of: results_in_transport_across GO:0005635 ! nuclear envelope + +[Term] +id: GO:0006611 +name: protein export from nucleus +namespace: biological_process +alt_id: GO:0097349 +def: "The directed movement of a protein from the nucleus into the cytoplasm." [GOC:jl] +synonym: "copper-induced protein export from nucleus" RELATED [GOC:al] +synonym: "protein export from cell nucleus" EXACT [] +synonym: "protein export out of nucleus" EXACT [] +synonym: "protein transport from nucleus to cytoplasm" EXACT [] +synonym: "protein-nucleus export" EXACT [] +is_a: GO:0006886 ! intracellular protein transport +is_a: GO:0051168 ! nuclear export +intersection_of: GO:0006810 ! transport +intersection_of: has_primary_input PR:000000001 ! protein +intersection_of: has_target_end_location GO:0005829 ! cytosol +intersection_of: has_target_start_location GO:0031981 ! nuclear lumen +intersection_of: results_in_transport_across GO:0005635 ! nuclear envelope + [Term] id: GO:0006624 name: vacuolar protein processing @@ -50118,22 +49904,25 @@ relationship: never_in_taxon NCBITaxon:4751 ! Fungi property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/24907" xsd:anyURI [Term] -id: GO:0006914 -name: autophagy +id: GO:0006913 +name: nucleocytoplasmic transport namespace: biological_process -alt_id: GO:0016238 -def: "The cellular catabolic process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation." [GOC:autophagy, ISBN:0198547684, PMID:11099404, PMID:9412464] +alt_id: GO:0000063 +def: "The directed movement of molecules between the nucleus and the cytoplasm." [GOC:go_curators] +comment: Note that transport through the nuclear pore complex is not transmembrane because the nuclear membrane is a double membrane, and is not traversed. subset: goslim_chembl subset: goslim_drosophila subset: goslim_generic -subset: goslim_pir subset: goslim_pombe -xref: Wikipedia:Autophagy_(cellular) -is_a: GO:0044248 ! cellular catabolic process -is_a: GO:0061919 ! process utilizing autophagic mechanism -relationship: ends_with GO:0055085 ! transmembrane transport -relationship: in_taxon NCBITaxon:2759 {all_only="true"} ! Eukaryota -relationship: only_in_taxon NCBITaxon:2759 ! Eukaryota +synonym: "nucleocytoplasmic shuttling" NARROW [] +is_a: GO:0051169 ! nuclear transport +intersection_of: GO:0006810 ! transport +intersection_of: results_in_transport_across GO:0005635 ! nuclear envelope +intersection_of: results_in_transport_to_from_or_in GO:0005829 ! cytosol +intersection_of: results_in_transport_to_from_or_in GO:0031981 ! nuclear lumen +relationship: results_in_transport_across GO:0005635 ! nuclear envelope +relationship: results_in_transport_to_from_or_in GO:0005829 ! cytosol +relationship: results_in_transport_to_from_or_in GO:0031981 ! nuclear lumen [Term] id: GO:0006915 @@ -51333,6 +51122,39 @@ intersection_of: GO:0016477 ! cell migration intersection_of: results_in_movement_of CL:0000579 ! border follicle cell relationship: results_in_movement_of CL:0000579 ! border follicle cell +[Term] +id: GO:0007300 +name: ovarian nurse cell to oocyte transport +namespace: biological_process +def: "Transfer of constituents synthesized in the ovarian nurse cells to the oocyte, through the ring canals, as the egg chamber is growing. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] +synonym: "nurse cell to oocyte transport" BROAD [] +is_a: GO:0006810 ! transport +is_a: GO:0022414 ! reproductive process +intersection_of: GO:0006810 ! transport +intersection_of: has_target_end_location CL:0000023 ! oocyte +intersection_of: has_target_start_location CL:0000026 ! invertebrate nurse cell +intersection_of: results_in_transport_along GO:0045172 ! germline ring canal +relationship: has_target_end_location CL:0000023 ! oocyte +relationship: has_target_start_location CL:0000026 ! invertebrate nurse cell +relationship: in_taxon NCBITaxon:50557 {all_only="true"} ! Insecta +relationship: only_in_taxon NCBITaxon:50557 ! Insecta +relationship: part_of GO:0048477 ! oogenesis +relationship: results_in_transport_along GO:0045172 ! germline ring canal + +[Term] +id: GO:0007303 +name: cytoplasmic transport, nurse cell to oocyte +namespace: biological_process +def: "The directed movement of cytoplasmic constituents synthesized in the nurse cells to the oocyte." [ISBN:0879694238] +is_a: GO:0016482 ! cytosolic transport +is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism +intersection_of: GO:0016482 ! cytosolic transport +intersection_of: has_target_end_location CL:0000023 ! oocyte +intersection_of: has_target_start_location CL:0000026 ! invertebrate nurse cell +relationship: has_target_end_location CL:0000023 ! oocyte +relationship: has_target_start_location CL:0000026 ! invertebrate nurse cell +relationship: part_of GO:0007300 ! ovarian nurse cell to oocyte transport + [Term] id: GO:0007308 name: oocyte construction @@ -52350,26 +52172,6 @@ subset: goslim_yeast subset: prokaryote_subset is_a: GO:0005515 ! protein binding -[Term] -id: GO:0008094 -name: ATP-dependent activity, acting on DNA -namespace: molecular_function -alt_id: GO:0004011 -def: "Catalytic activity that acts to modify DNA, driven by ATP hydrolysis." [GOC:pdt] -synonym: "adenosinetriphosphatase (DNA-dependent)" EXACT [] -synonym: "ATPase activity, acting on DNA" EXACT [] -synonym: "ATPase, acting on DNA" EXACT [] -synonym: "DNA dependent ATPase activity" EXACT [] -synonym: "DNA-dependent adenosinetriphosphatase activity" EXACT [] -synonym: "DNA-dependent ATPase activity" EXACT [] -is_a: GO:0140097 ! catalytic activity, acting on DNA -is_a: GO:0140657 ! ATP-dependent activity -intersection_of: GO:0140097 ! catalytic activity, acting on DNA -intersection_of: has_part GO:0016887 ! ATP hydrolysis activity -property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/20876" xsd:anyURI -property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/21612" xsd:anyURI -property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/21775" xsd:anyURI - [Term] id: GO:0008104 name: protein localization @@ -52460,25 +52262,6 @@ disjoint_from: GO:0051179 ! localization created_by: jl creation_date: 2012-10-17T15:46:40Z -[Term] -id: GO:0008186 -name: ATP-dependent activity, acting on RNA -namespace: molecular_function -alt_id: GO:0004010 -def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of RNA, and it drives another reaction." [GOC:jl] -synonym: "ATPase activity, acting on RNA" EXACT [] -synonym: "ATPase, acting on RNA" EXACT [] -synonym: "RNA-dependent adenosinetriphosphatase activity" EXACT [] -synonym: "RNA-dependent ATPase activity" EXACT [] -xref: Reactome:R-HSA-9770847 "Spliceosomal P complex dissociates yielding the intron-containing complex (ILS) and the spliced mRNP (new)" -xref: Reactome:R-HSA-9772351 "Disassembly of the Intron Lariat Spliceosome (new)" -is_a: GO:0140657 ! ATP-dependent activity -intersection_of: GO:0140657 ! ATP-dependent activity -intersection_of: has_input CHEBI:33697 -relationship: has_input CHEBI:33697 -property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/20876" xsd:anyURI -property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/21775" xsd:anyURI - [Term] id: GO:0008188 name: neuropeptide receptor activity @@ -52596,10 +52379,12 @@ id: GO:0008219 name: cell death namespace: biological_process def: "Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538)." [GOC:mah, GOC:mtg_apoptosis, PMID:25236395] -comment: This term should not be used for direct annotation. The only exception should be when experimental data (e.g., staining with trypan blue or propidium iodide) show that cell death has occurred, but fail to provide details on death modality (accidental versus programmed). When information is provided on the cell death mechanism, annotations should be made to the appropriate descendant of 'cell death' (such as, but not limited to, GO:0097300 'programmed necrotic cell death' or GO:0006915 'apoptotic process'). Also, if experimental data suggest that a gene product influences cell death indirectly, rather than being involved in the death process directly, consider annotating to a 'regulation' term. +comment: This term should not be used for direct annotation, it is currently kept in GO as a placeholder for describing cell death phenotypes in uPHENO. When information is provided on a programmed cell death mechanism, annotations should be made to the appropriate descendant of 'cell death' (such as, but not limited to, GO:0097300 'programmed necrotic cell death' or GO:0006915 'apoptotic process'). Unintentional cell death, i.e. cell death caused by injury, ageing, or cell phenotypes observed as a result of a pathological mutation in an essential gene should NOT be annotated using GO terms. +subset: gocheck_do_not_annotate synonym: "accidental cell death" RELATED [] synonym: "necrosis" RELATED [] is_a: GO:0009987 ! cellular process +property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/24680" xsd:anyURI [Term] id: GO:0008227 @@ -53025,19 +52810,6 @@ intersection_of: GO:0009058 ! biosynthetic process intersection_of: has_primary_output CHEBI:18059 relationship: has_primary_output CHEBI:18059 -[Term] -id: GO:0008641 -name: ubiquitin-like modifier activating enzyme activity -namespace: molecular_function -alt_id: GO:0008642 -def: "Catalysis of the activation of small proteins, such as ubiquitin or ubiquitin-like proteins, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:jl, GOC:mah] -subset: goslim_pir -synonym: "small protein activating enzyme activity" NARROW [] -is_a: GO:0016877 ! ligase activity, forming carbon-sulfur bonds -is_a: GO:0140096 ! catalytic activity, acting on a protein -is_a: GO:0140657 ! ATP-dependent activity -property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/14208" xsd:anyURI - [Term] id: GO:0008643 name: carbohydrate transport @@ -53168,11 +52940,13 @@ synonym: "macromolecule biosynthesis" EXACT [] synonym: "macromolecule formation" EXACT [] synonym: "macromolecule synthesis" EXACT [] is_a: GO:0043170 ! macromolecule metabolic process +is_a: GO:0044249 ! cellular biosynthetic process is_a: GO:1901576 ! organic substance biosynthetic process intersection_of: GO:0009058 ! biosynthetic process intersection_of: has_primary_output CHEBI:33694 relationship: has_primary_output CHEBI:33694 -property_value: term_tracker_item "http://amigo.geneontology.org/amigo/term/GO:0070589" xsd:anyURI +property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/15249" xsd:anyURI +property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/25418" xsd:anyURI [Term] id: GO:0009063 @@ -53297,86 +53071,6 @@ intersection_of: GO:0009058 ! biosynthetic process intersection_of: has_primary_output CHEBI:17089 relationship: has_primary_output CHEBI:17089 -[Term] -id: GO:0009132 -name: nucleoside diphosphate metabolic process -namespace: biological_process -def: "The chemical reactions and pathways involving a nucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] -synonym: "nucleoside diphosphate metabolism" EXACT [] -is_a: GO:0008152 ! metabolic process -intersection_of: GO:0008152 ! metabolic process -intersection_of: has_primary_input_or_output CHEBI:57930 -relationship: has_primary_input_or_output CHEBI:57930 - -[Term] -id: GO:0009133 -name: nucleoside diphosphate biosynthetic process -namespace: biological_process -def: "The chemical reactions and pathways resulting in the formation of a nucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] -synonym: "nucleoside diphosphate anabolism" EXACT [] -synonym: "nucleoside diphosphate biosynthesis" EXACT [] -synonym: "nucleoside diphosphate formation" EXACT [] -synonym: "nucleoside diphosphate synthesis" EXACT [] -is_a: GO:0009058 ! biosynthetic process -is_a: GO:0009132 ! nucleoside diphosphate metabolic process -intersection_of: GO:0009058 ! biosynthetic process -intersection_of: has_primary_output CHEBI:57930 -relationship: has_primary_output CHEBI:57930 - -[Term] -id: GO:0009134 -name: nucleoside diphosphate catabolic process -namespace: biological_process -def: "The chemical reactions and pathways resulting in the breakdown of a nucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] -synonym: "nucleoside diphosphate breakdown" EXACT [] -synonym: "nucleoside diphosphate catabolism" EXACT [] -synonym: "nucleoside diphosphate degradation" EXACT [] -is_a: GO:0009056 ! catabolic process -is_a: GO:0009132 ! nucleoside diphosphate metabolic process -intersection_of: GO:0009056 ! catabolic process -intersection_of: has_primary_input CHEBI:57930 -relationship: has_primary_input CHEBI:57930 - -[Term] -id: GO:0009141 -name: nucleoside triphosphate metabolic process -namespace: biological_process -def: "The chemical reactions and pathways involving a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] -synonym: "nucleoside triphosphate metabolism" EXACT [] -is_a: GO:0008152 ! metabolic process -intersection_of: GO:0008152 ! metabolic process -intersection_of: has_primary_input_or_output CHEBI:61557 -relationship: has_primary_input_or_output CHEBI:61557 - -[Term] -id: GO:0009142 -name: nucleoside triphosphate biosynthetic process -namespace: biological_process -def: "The chemical reactions and pathways resulting in the formation of a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] -synonym: "nucleoside triphosphate anabolism" EXACT [] -synonym: "nucleoside triphosphate biosynthesis" EXACT [] -synonym: "nucleoside triphosphate formation" EXACT [] -synonym: "nucleoside triphosphate synthesis" EXACT [] -is_a: GO:0009058 ! biosynthetic process -is_a: GO:0009141 ! nucleoside triphosphate metabolic process -intersection_of: GO:0009058 ! biosynthetic process -intersection_of: has_primary_output CHEBI:61557 -relationship: has_primary_output CHEBI:61557 - -[Term] -id: GO:0009143 -name: nucleoside triphosphate catabolic process -namespace: biological_process -def: "The chemical reactions and pathways resulting in the breakdown of a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] -synonym: "nucleoside triphosphate breakdown" EXACT [] -synonym: "nucleoside triphosphate catabolism" EXACT [] -synonym: "nucleoside triphosphate degradation" EXACT [] -is_a: GO:0009056 ! catabolic process -is_a: GO:0009141 ! nucleoside triphosphate metabolic process -intersection_of: GO:0009056 ! catabolic process -intersection_of: has_primary_input CHEBI:61557 -relationship: has_primary_input CHEBI:61557 - [Term] id: GO:0009250 name: glucan biosynthetic process @@ -54529,11 +54223,12 @@ relationship: regulates GO:0010463 ! mesenchymal cell proliferation id: GO:0010467 name: gene expression namespace: biological_process -def: "The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, translation and maturation for protein-coding genes." [GOC:txnOH-2018, PMID:25934543, PMID:31580950] +def: "The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, as well as translation and maturation for protein-coding genes." [GOC:txnOH-2018, PMID:25934543, PMID:31580950] subset: goslim_flybase_ribbon xref: Wikipedia:Gene_expression -is_a: GO:0043170 ! macromolecule metabolic process +is_a: GO:0009059 ! macromolecule biosynthetic process property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/22557" xsd:anyURI +property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/25419" xsd:anyURI [Term] id: GO:0010468 @@ -54545,7 +54240,7 @@ synonym: "gene regulation" RELATED [GOC:cjm] synonym: "regulation of gene product expression" RELATED [] synonym: "regulation of protein expression" NARROW [] xref: Wikipedia:Regulation_of_gene_expression -is_a: GO:0060255 ! regulation of macromolecule metabolic process +is_a: GO:0010556 ! regulation of macromolecule biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0010467 ! gene expression relationship: regulates GO:0010467 ! gene expression @@ -54618,38 +54313,6 @@ relationship: results_in_transport_across GO:0005615 ! extracellular space created_by: jl creation_date: 2013-12-19T13:24:56Z -[Term] -id: GO:0010506 -name: regulation of autophagy -namespace: biological_process -def: "Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb] -is_a: GO:0031329 ! regulation of cellular catabolic process -intersection_of: GO:0065007 ! biological regulation -intersection_of: regulates GO:0006914 ! autophagy -relationship: regulates GO:0006914 ! autophagy - -[Term] -id: GO:0010507 -name: negative regulation of autophagy -namespace: biological_process -def: "Any process that stops, prevents, or reduces the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb] -is_a: GO:0010506 ! regulation of autophagy -is_a: GO:0031330 ! negative regulation of cellular catabolic process -intersection_of: GO:0065007 ! biological regulation -intersection_of: negatively_regulates GO:0006914 ! autophagy -relationship: negatively_regulates GO:0006914 ! autophagy - -[Term] -id: GO:0010508 -name: positive regulation of autophagy -namespace: biological_process -def: "Any process that activates, maintains or increases the rate of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb] -is_a: GO:0010506 ! regulation of autophagy -is_a: GO:0031331 ! positive regulation of cellular catabolic process -intersection_of: GO:0065007 ! biological regulation -intersection_of: positively_regulates GO:0006914 ! autophagy -relationship: positively_regulates GO:0006914 ! autophagy - [Term] id: GO:0010543 name: regulation of platelet activation @@ -54687,7 +54350,7 @@ id: GO:0010556 name: regulation of macromolecule biosynthetic process namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] -is_a: GO:0009889 ! regulation of biosynthetic process +is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0060255 ! regulation of macromolecule metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0009059 ! macromolecule biosynthetic process @@ -54698,9 +54361,9 @@ id: GO:0010557 name: positive regulation of macromolecule biosynthetic process namespace: biological_process def: "Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] -is_a: GO:0009891 ! positive regulation of biosynthetic process is_a: GO:0010556 ! regulation of macromolecule biosynthetic process is_a: GO:0010604 ! positive regulation of macromolecule metabolic process +is_a: GO:0031328 ! positive regulation of cellular biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0009059 ! macromolecule biosynthetic process relationship: positively_regulates GO:0009059 ! macromolecule biosynthetic process @@ -54710,9 +54373,9 @@ id: GO:0010558 name: negative regulation of macromolecule biosynthetic process namespace: biological_process def: "Any process that decreases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] -is_a: GO:0009890 ! negative regulation of biosynthetic process is_a: GO:0010556 ! regulation of macromolecule biosynthetic process is_a: GO:0010605 ! negative regulation of macromolecule metabolic process +is_a: GO:0031327 ! negative regulation of cellular biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0009059 ! macromolecule biosynthetic process relationship: negatively_regulates GO:0009059 ! macromolecule biosynthetic process @@ -54985,7 +54648,7 @@ name: positive regulation of gene expression namespace: biological_process def: "Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA)." [GOC:txnOH-2018] is_a: GO:0010468 ! regulation of gene expression -is_a: GO:0010604 ! positive regulation of macromolecule metabolic process +is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0010467 ! gene expression relationship: positively_regulates GO:0010467 ! gene expression @@ -54999,7 +54662,7 @@ def: "Any process that decreases the frequency, rate or extent of gene expressio comment: This term covers any process that negatively regulates the rate of production of a mature gene product, and so includes processes that negatively regulate that rate by reducing the level, stability or availability of intermediates in the process of gene expression. For example, it covers any process that reduces the level, stability or availability of mRNA or circRNA for translation and thereby reduces the rate of production of the encoded protein via translation. synonym: "gene silencing" RELATED [] is_a: GO:0010468 ! regulation of gene expression -is_a: GO:0010605 ! negative regulation of macromolecule metabolic process +is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0010467 ! gene expression relationship: negatively_regulates GO:0010467 ! gene expression @@ -55579,37 +55242,29 @@ intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0010761 ! fibroblast migration relationship: negatively_regulates GO:0010761 ! fibroblast migration -[Term] -id: GO:0010769 -name: regulation of cell morphogenesis involved in differentiation -namespace: biological_process -def: "Any process that modulates the frequency, rate or extent of cell morphogenesis contributing to cell differentiation. Cell morphogenesis involved in differentiation is the change in form (cell shape and size) that occurs when relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history." [GOC:dph, GOC:tb] -is_a: GO:0022604 ! regulation of cell morphogenesis -intersection_of: GO:0065007 ! biological regulation -intersection_of: regulates GO:0000904 ! cell morphogenesis involved in differentiation -relationship: regulates GO:0000904 ! cell morphogenesis involved in differentiation - [Term] id: GO:0010770 -name: positive regulation of cell morphogenesis involved in differentiation +name: positive regulation of cell morphogenesis namespace: biological_process def: "Any process that increases the frequency, rate or extent of cell morphogenesis contributing to cell differentiation. Cell morphogenesis involved in differentiation is the change in form (cell shape and size) that occurs when relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history." [GOC:dph, GOC:tb] is_a: GO:0010720 ! positive regulation of cell development -is_a: GO:0010769 ! regulation of cell morphogenesis involved in differentiation +is_a: GO:0022604 ! regulation of cell morphogenesis intersection_of: GO:0065007 ! biological regulation -intersection_of: positively_regulates GO:0000904 ! cell morphogenesis involved in differentiation -relationship: positively_regulates GO:0000904 ! cell morphogenesis involved in differentiation +intersection_of: positively_regulates GO:0000902 ! cell morphogenesis +relationship: positively_regulates GO:0000902 ! cell morphogenesis +property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/24299" xsd:anyURI [Term] id: GO:0010771 -name: negative regulation of cell morphogenesis involved in differentiation +name: negative regulation of cell morphogenesis namespace: biological_process def: "Any process that decreases the frequency, rate or extent of cell morphogenesis contributing to cell differentiation. Cell morphogenesis involved in differentiation is the change in form (cell shape and size) that occurs when relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history." [GOC:dph, GOC:tb] is_a: GO:0010721 ! negative regulation of cell development -is_a: GO:0010769 ! regulation of cell morphogenesis involved in differentiation +is_a: GO:0022604 ! regulation of cell morphogenesis intersection_of: GO:0065007 ! biological regulation -intersection_of: negatively_regulates GO:0000904 ! cell morphogenesis involved in differentiation -relationship: negatively_regulates GO:0000904 ! cell morphogenesis involved in differentiation +intersection_of: negatively_regulates GO:0000902 ! cell morphogenesis +relationship: negatively_regulates GO:0000902 ! cell morphogenesis +property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/24299" xsd:anyURI [Term] id: GO:0010816 @@ -55982,6 +55637,19 @@ relationship: negatively_regulates GO:0016485 ! protein processing created_by: tb creation_date: 2009-04-27T12:10:19Z +[Term] +id: GO:0010958 +name: regulation of amino acid import across plasma membrane +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of amino acid import into a cell." [GOC:dph, GOC:tb] +synonym: "regulation of amino acid import" BROAD [] +is_a: GO:1903789 ! regulation of amino acid transmembrane transport +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:0089718 ! amino acid import across plasma membrane +relationship: regulates GO:0089718 ! amino acid import across plasma membrane +created_by: tb +creation_date: 2009-05-06T11:33:12Z + [Term] id: GO:0010962 name: regulation of glucan biosynthetic process @@ -57740,6 +57408,21 @@ is_a: GO:0022839 ! monoatomic ion gated channel activity intersection_of: GO:0022834 ! ligand-gated channel activity intersection_of: has_primary_input CHEBI:24867 +[Term] +id: GO:0015278 +name: calcium-release channel activity +namespace: molecular_function +alt_id: GO:0005218 +def: "Enables the transmembrane transfer of a calcium ion from intracellular stores by a channel that opens when a specific intracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mah] +synonym: "intracellular ligand-gated calcium channel activity" RELATED [GO:0015278] +xref: Reactome:R-HSA-9717215 "ITPR3 transports Ca2+ from the endoplasmic reticulum to the cytosol" +is_a: GO:0005217 ! intracellular ligand-gated monoatomic ion channel activity +is_a: GO:0099604 ! ligand-gated calcium channel activity +intersection_of: GO:0022834 ! ligand-gated channel activity +intersection_of: has_primary_input CHEBI:29108 +intersection_of: part_of GO:0051209 ! release of sequestered calcium ion into cytosol +relationship: part_of GO:0051209 ! release of sequestered calcium ion into cytosol + [Term] id: GO:0015318 name: inorganic molecular entity transmembrane transporter activity @@ -58348,63 +58031,6 @@ intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0014706 ! striated muscle tissue development relationship: regulates GO:0014706 ! striated muscle tissue development -[Term] -id: GO:0016236 -name: macroautophagy -namespace: biological_process -alt_id: GO:0034262 -def: "The major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane-bounded autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane-bounded structure. Autophagosomes then fuse with a lysosome (or vacuole) releasing single-membrane-bounded autophagic bodies that are then degraded within the lysosome (or vacuole). Some types of macroautophagy, e.g. pexophagy, mitophagy, involve selective targeting of the targets to be degraded." [PMID:11099404, PMID:12914914, PMID:15798367, PMID:16973210, PMID:20159618, PMID:9412464] -comment: Targeted macroautophagy sometimes targets regions of cytoplasm containing non-self, such as virus particles or components (e.g. see PMID:20159618). As this is essentially the same process as macroautophagy that encloses and digests only self, the term autophagy is still used despite the enclosure of some non-self (non-auto) entities. -synonym: "autophagy" BROAD [] -is_a: GO:0006914 ! autophagy -intersection_of: GO:0006914 ! autophagy -intersection_of: starts_with GO:0000045 ! autophagosome assembly -relationship: starts_with GO:0000045 ! autophagosome assembly - -[Term] -id: GO:0016239 -name: positive regulation of macroautophagy -namespace: biological_process -def: "Any process, such as recognition of nutrient depletion, that activates or increases the rate of macroautophagy to bring cytosolic macromolecules to the vacuole/lysosome for degradation." [GOC:go_curators, PMID:9412464] -synonym: "activation of macroautophagy" NARROW [] -synonym: "positive regulation of starvation-induced autophagy" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] -synonym: "stimulation of macroautophagy" NARROW [] -synonym: "up regulation of macroautophagy" EXACT [] -synonym: "up-regulation of macroautophagy" EXACT [] -synonym: "upregulation of macroautophagy" EXACT [] -is_a: GO:0010508 ! positive regulation of autophagy -is_a: GO:0016241 ! regulation of macroautophagy -intersection_of: GO:0065007 ! biological regulation -intersection_of: positively_regulates GO:0016236 ! macroautophagy -relationship: positively_regulates GO:0016236 ! macroautophagy - -[Term] -id: GO:0016241 -name: regulation of macroautophagy -namespace: biological_process -def: "Any process that modulates the frequency, rate or extent of macroautophagy." [GOC:krc] -synonym: "regulation of starvation-induced autophagy" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] -is_a: GO:0010506 ! regulation of autophagy -intersection_of: GO:0065007 ! biological regulation -intersection_of: regulates GO:0016236 ! macroautophagy -relationship: regulates GO:0016236 ! macroautophagy - -[Term] -id: GO:0016242 -name: negative regulation of macroautophagy -namespace: biological_process -def: "Any process that stops, prevents, or reduces the frequency, rate or extent of macroautophagy." [GOC:go_curators] -synonym: "down regulation of macroautophagy" EXACT [] -synonym: "down-regulation of macroautophagy" EXACT [] -synonym: "downregulation of macroautophagy" EXACT [] -synonym: "inhibition of macroautophagy" NARROW [] -synonym: "negative regulation of starvation-induced autophagy" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] -is_a: GO:0010507 ! negative regulation of autophagy -is_a: GO:0016241 ! regulation of macroautophagy -intersection_of: GO:0065007 ! biological regulation -intersection_of: negatively_regulates GO:0016236 ! macroautophagy -relationship: negatively_regulates GO:0016236 ! macroautophagy - [Term] id: GO:0016301 name: kinase activity @@ -58521,14 +58147,6 @@ synonym: "somatic recombination of antibody gene segments" EXACT [] is_a: GO:0002562 ! somatic diversification of immune receptors via germline recombination within a single locus is_a: GO:0016445 ! somatic diversification of immunoglobulins -[Term] -id: GO:0016462 -name: pyrophosphatase activity -namespace: molecular_function -def: "Catalysis of the hydrolysis of a pyrophosphate bond (diphosphate bond) between two phosphate groups." [GOC:curators, https://en.wikipedia.org/wiki/Pyrophosphatase] -xref: Reactome:R-HSA-6810472 "NUDT13 hydrolyses AP6A to AP4 and ADP" -is_a: GO:0016818 ! hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides - [Term] id: GO:0016477 name: cell migration @@ -58539,6 +58157,16 @@ is_a: GO:0048870 ! cell motility relationship: never_in_taxon NCBITaxon:4890 ! Ascomycota property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/24787" xsd:anyURI +[Term] +id: GO:0016482 +name: cytosolic transport +namespace: biological_process +def: "The directed movement of substances or organelles within the cytosol." [GOC:ai] +is_a: GO:0046907 ! intracellular transport +intersection_of: GO:0006810 ! transport +intersection_of: occurs_in GO:0005829 ! cytosol +relationship: occurs_in GO:0005829 ! cytosol + [Term] id: GO:0016485 name: protein processing @@ -58656,33 +58284,6 @@ xref: Reactome:R-HSA-5668414 "TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2 xref: Reactome:R-HSA-8868783 "TSR3 transfers aminocarboxypropyl group from S-adenosylmethionine to N(1)-methylpseudouridine-1248 of 18SE rRNA yielding N(1)-methyl-N(3)-aminocarboxypropylpseudouridine-1248" is_a: GO:0003824 ! catalytic activity -[Term] -id: GO:0016746 -name: acyltransferase activity -namespace: molecular_function -alt_id: GO:0008415 -def: "Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] -subset: goslim_chembl -subset: goslim_drosophila -synonym: "transferase activity, transferring acyl groups" EXACT [] -xref: EC:2.3.-.- -xref: Reactome:R-HSA-159431 "Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine" -xref: Reactome:R-HSA-192312 "Choloyl CoA reacts with glycine or taurine to form glycocholate or taurocholate" -xref: Reactome:R-HSA-193491 "Chenodeoxycholoyl CoA reacts with glycine or taurine to form glycochenodeoxycholate or taurochenodeoxycholate" -xref: Reactome:R-HSA-6792572 "LIPT1 transfers lipoyl group from lipoyl-GCSH to DHs" -xref: Reactome:R-HSA-8858298 "HRASLS transfer acyl group from PC to PE to form NAPE" -is_a: GO:0016740 ! transferase activity -property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/20486" xsd:anyURI - -[Term] -id: GO:0016755 -name: aminoacyltransferase activity -namespace: molecular_function -def: "Catalysis of the transfer of an amino-acyl group from one compound (donor) to another (acceptor)." [GOC:jl] -synonym: "transferase activity, transferring amino-acyl groups" EXACT [] -xref: EC:2.3.2.- -is_a: GO:0016746 ! acyltransferase activity - [Term] id: GO:0016772 name: transferase activity, transferring phosphorus-containing groups @@ -58743,98 +58344,6 @@ xref: Reactome:R-HSA-9023619 "Platelet-activating factor acetylhydrolase (PLA2G7 xref: Reactome:R-HSA-9749609 "BCHE hydrolyzes ASA-" is_a: GO:0016787 ! hydrolase activity -[Term] -id: GO:0016817 -name: hydrolase activity, acting on acid anhydrides -namespace: molecular_function -def: "Catalysis of the hydrolysis of any acid anhydride." [GOC:jl] -synonym: "hydrolase activity, acting on acid anhydrides, involved in cellular and subcellular movement" NARROW [] -xref: EC:3.6.-.- -is_a: GO:0016787 ! hydrolase activity - -[Term] -id: GO:0016818 -name: hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides -namespace: molecular_function -def: "Catalysis of the hydrolysis of any acid anhydride which contains phosphorus." [GOC:jl] -xref: EC:3.6.1.- -xref: Reactome:R-HSA-9731590 "NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP" -xref: Reactome:R-HSA-9731613 "NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP" -xref: Reactome:R-HSA-9731632 "NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP" -is_a: GO:0016817 ! hydrolase activity, acting on acid anhydrides - -[Term] -id: GO:0016874 -name: ligase activity -namespace: molecular_function -def: "Catalysis of the joining of two molecules, or two groups within a single molecule, using the energy from the hydrolysis of ATP, a similar triphosphate, or a pH gradient." [GOC:mah] -subset: goslim_candida -subset: goslim_chembl -subset: goslim_drosophila -subset: goslim_generic -subset: goslim_metagenomics -subset: goslim_mouse -subset: goslim_pir -subset: goslim_yeast -subset: prokaryote_subset -synonym: "synthetase activity" EXACT [GOC:jh2] -xref: EC:6.-.-.- -is_a: GO:0003824 ! catalytic activity -property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/19380" xsd:anyURI - -[Term] -id: GO:0016877 -name: ligase activity, forming carbon-sulfur bonds -namespace: molecular_function -def: "Catalysis of the joining of two molecules via a carbon-sulfur bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6.2.-.-, GOC:mah] -synonym: "ligase activity, forming carbon-sulphur bonds" EXACT [] -xref: EC:6.2.-.- -is_a: GO:0016874 ! ligase activity - -[Term] -id: GO:0016887 -name: ATP hydrolysis activity -namespace: molecular_function -alt_id: GO:0004002 -alt_id: GO:0042623 -def: "Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." [RHEA:13065] -comment: Note that this term is meant to specifically represent the ATPase activity of proteins using ATP as a source of energy to drive a reaction. If possible, gene products should also be annotated to a child of 'ATP-dependent activity ; GO:0140657', to capture their overall function. -synonym: "adenosine 5'-triphosphatase activity" EXACT [] -synonym: "adenosine triphosphatase activity" EXACT [] -synonym: "adenosinetriphosphatase activity" EXACT [] -synonym: "ATP hydrolase activity" EXACT [] -synonym: "ATP monophosphatase activity" RELATED [] -synonym: "ATP phosphohydrolase activity" EXACT [] -xref: Reactome:R-HSA-159101 "NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B)" -xref: Reactome:R-HSA-3371422 "ATP hydrolysis by HSP70" -xref: Reactome:R-HSA-416985 "Trafficking of GluR2-containing AMPA receptors to synapse" -xref: Reactome:R-HSA-5618093 "ATP hydrolysis by HSP90" -xref: Reactome:R-HSA-5654989 "SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA" -xref: Reactome:R-HSA-5694425 "NSF ATPase activity dissociates cis-SNARE" -xref: Reactome:R-HSA-6809015 "NSF ATPase activity dissociates cis-SNARE at cis-Golgi" -xref: Reactome:R-HSA-6811422 "NSF ATPase activity dissociates cis-SNARE at the ER" -xref: Reactome:R-HSA-6814670 "ATP hydrolysis by RHOBTB3 promotes PLIN3 dissociation" -xref: Reactome:R-HSA-6814678 "ATP hydrolysis by NSF disassembles the cis-SNARE at the TGN" -xref: Reactome:R-HSA-6814683 "NSF-dependent ATP hydrolysis disassembles the cis-SNARE at the TGN" -xref: Reactome:R-HSA-8847638 "ATP hydrolysis by NSF disassembles the cis-SNARE at the Golgi membrane" -xref: Reactome:R-HSA-8868658 "HSPA8-mediated ATP hydrolysis promotes vesicle uncoating" -xref: Reactome:R-HSA-8939203 "HSP90-dependent ATP hydrolysis promotes release of ESR:ESTG from chaperone complex" -xref: Reactome:R-HSA-9038161 "Progesterone stimulation promotes PGR:P4 binding to ESR1:ESTG" -xref: Reactome:R-HSA-917693 "ESCRT Disassembly" -xref: Reactome:R-HSA-9609860 "Tail-anchored protein:SGTA:BAG6:GET4:UBL4A:ASNA1:ATP dissociates and ASNA1 hydrolyzes ATP yielding Tail-anchored protein:ASNA1:ADP" -xref: Reactome:R-HSA-9668415 "VPS4 mediates disassembly of ESCRTIII subunits to promote sealing of holes in the nuclear envelope" -xref: Reactome:R-HSA-9706399 "RHOBTB3 hydrolyzes ATP" -xref: Reactome:R-HSA-9749350 "ATP-dependent release of CDT1 from the OCCM complex" -xref: RHEA:13065 -is_a: GO:0017111 ! ribonucleoside triphosphate phosphatase activity -relationship: has_participant CHEBI:30616 -relationship: has_participant CHEBI:456216 -relationship: part_of GO:0140657 ! ATP-dependent activity -property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/19078" xsd:anyURI -property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/20498" xsd:anyURI -property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/21612" xsd:anyURI -property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/22371" xsd:anyURI - [Term] id: GO:0016907 name: G protein-coupled acetylcholine receptor activity @@ -58881,40 +58390,6 @@ intersection_of: GO:0005488 ! binding intersection_of: has_input CHEBI:25905 relationship: has_input CHEBI:25905 -[Term] -id: GO:0017111 -name: ribonucleoside triphosphate phosphatase activity -namespace: molecular_function -def: "Catalysis of the reaction: a ribonucleoside triphosphate + H2O = a ribonucleoside diphosphate + H+ + phosphate." [RHEA:23680] -subset: goslim_chembl -subset: goslim_metagenomics -synonym: "apyrase activity" BROAD [] -synonym: "NTPase activity" EXACT [] -synonym: "nucleoside 5-triphosphatase activity" BROAD [EC:3.6.1.15] -synonym: "nucleoside triphosphatase activity" BROAD [] -synonym: "nucleoside triphosphate hydrolase activity" BROAD [] -synonym: "nucleoside triphosphate phosphatase activity" BROAD [] -synonym: "nucleoside triphosphate phosphohydrolase activity" RELATED [] -synonym: "nucleoside-5-triphosphate phosphohydrolase activity" RELATED [] -synonym: "nucleoside-triphosphatase activity" BROAD [] -xref: EC:3.6.1.15 -xref: MetaCyc:NUCLEOSIDE-TRIPHOSPHATASE-RXN -xref: Reactome:R-HSA-8850846 "NTPDase1 hydrolyzes nucleoside triphosphates" -xref: Reactome:R-HSA-8851089 "NTPDase2 hydrolyzes nucleoside triphosphates" -xref: Reactome:R-HSA-8851110 "NTPDase3 hydrolyzes nucleoside triphosphates" -xref: Reactome:R-HSA-8851234 "NTPDase4 hydrolyzes nucleoside triphosphates" -xref: Reactome:R-HSA-8851494 "NTPDase7 hydrolyzes nucleoside triphosphates" -xref: Reactome:R-HSA-8851538 "NTPDase8 hydrolyzes nucleoside triphosphates" -xref: RHEA:23680 -is_a: GO:0016462 ! pyrophosphatase activity -relationship: has_participant CHEBI:15377 -relationship: has_participant CHEBI:15378 -relationship: has_participant CHEBI:43474 -relationship: has_participant CHEBI:57930 -relationship: has_participant CHEBI:61557 -property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/21232" xsd:anyURI -property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/23401" xsd:anyURI - [Term] id: GO:0017126 name: nucleologenesis @@ -58957,7 +58432,6 @@ synonym: "negative regulation of protein synthesis" EXACT [] synonym: "protein biosynthesis inhibitor activity" RELATED [] synonym: "protein biosynthetic process inhibitor activity" RELATED [] is_a: GO:0006417 ! regulation of translation -is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process is_a: GO:0010629 ! negative regulation of gene expression is_a: GO:0051248 ! negative regulation of protein metabolic process intersection_of: GO:0065007 ! biological regulation @@ -59418,6 +58892,16 @@ synonym: "secondary metabolite metabolism" EXACT [] xref: Wikipedia:Secondary_metabolism is_a: GO:0008152 ! metabolic process +[Term] +id: GO:0019749 +name: cytoskeleton-dependent cytoplasmic transport, nurse cell to oocyte +namespace: biological_process +def: "The directed movement of substances along cytoskeletal elements, such as microfilaments or microtubules, from a nurse cell to an oocyte." [GOC:ai] +is_a: GO:0007303 ! cytoplasmic transport, nurse cell to oocyte +is_a: GO:0030705 ! cytoskeleton-dependent intracellular transport +intersection_of: GO:0007303 ! cytoplasmic transport, nurse cell to oocyte +intersection_of: GO:0030705 ! cytoskeleton-dependent intracellular transport + [Term] id: GO:0019752 name: carboxylic acid metabolic process @@ -59429,63 +58913,6 @@ intersection_of: GO:0008152 ! metabolic process intersection_of: has_primary_input_or_output CHEBI:29067 relationship: has_primary_input_or_output CHEBI:29067 -[Term] -id: GO:0019777 -name: Atg12 transferase activity -namespace: molecular_function -def: "Catalysis of the transfer of ATG12 from one protein to another via the reaction X-ATG12 + Y = Y-ATG12 + X, where both X-ATG12 and Y-ATG12 are covalent linkages." [GOC:mah, PMID:12826404] -synonym: "APG12 conjugating enzyme activity" NARROW [] -synonym: "APG12 ligase activity" NARROW [] -synonym: "Atg12 conjugating enzyme activity" NARROW [] -synonym: "Atg12 ligase activity" NARROW [] -xref: Reactome:R-HSA-5681999 "ATG10 transfers ATG12 from ATG7 to ATG10" -is_a: GO:0019787 ! ubiquitin-like protein transferase activity - -[Term] -id: GO:0019778 -name: Atg12 activating enzyme activity -namespace: molecular_function -def: "Catalysis of the activation of the small ubiquitin-related modifier APG12, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:mah] -synonym: "APG12 activating enzyme activity" RELATED [GOC:vw] -is_a: GO:0008641 ! ubiquitin-like modifier activating enzyme activity - -[Term] -id: GO:0019786 -name: protein-phosphatidylethanolamide deconjugating activity -namespace: molecular_function -def: "Catalysis of the reaction: [protein]-C-terminal L-amino acid-glycyl-phosphatidylethanolamide + H2O = [protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine. An example of this reaction is the removal of ATG8 from membranes to which it is covalently linked to a phosphatidylethanolamid via its terminal glycine residue." [PMID:22240591, PMID:22652539, PMID:28330855, PMID:2882172, PMID:28901328] -synonym: "APG8-PE hydrolase" RELATED [] {source="skos:narrowMatch"} -synonym: "APG8-specific protease activity" NARROW [GOC:vw] -synonym: "ATG8-PE deconjugation activity" NARROW [] {source="skos:narrowMatch"} -synonym: "ATG8-PE hydrolase activity" NARROW [] {source="skos:narrowMatch"} -synonym: "Atg8-specific peptidase activity" NARROW [] {source="skos:narrowMatch"} -synonym: "Atg8-specific protease activity" EXACT [] {source="skos:narrowMatch"} -is_a: GO:0016787 ! hydrolase activity -is_a: GO:0140096 ! catalytic activity, acting on a protein -property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/25472" xsd:anyURI - -[Term] -id: GO:0019787 -name: ubiquitin-like protein transferase activity -namespace: molecular_function -alt_id: GO:0008639 -alt_id: GO:0008640 -def: "Catalysis of the transfer of a ubiquitin-like from one protein to another via the reaction X-ULP + Y = Y-ULP + X, where both X-ULP and Y-ULP are covalent linkages. ULP represents a ubiquitin-like protein." [GOC:mah, GOC:rn, PMID:10806345, PMID:10884686] -subset: goslim_drosophila -subset: goslim_pir -synonym: "E2" BROAD [] -synonym: "E3" RELATED [GOC:dph] -synonym: "small conjugating protein ligase activity" NARROW [GOC:dph] -synonym: "small conjugating protein transferase activity" EXACT [GOC:dph] -synonym: "small protein conjugating enzyme activity" NARROW [] -synonym: "ubiquitin-like conjugating enzyme activity" NARROW [] -synonym: "ubiquitin-like-protein ligase activity" NARROW [] -xref: Reactome:R-HSA-5678490 "ATG16L1 complex transfers LC3 from ATG3 to PE" -xref: Reactome:R-HSA-688137 "RIP2 is K63 polyubiquitinated" -is_a: GO:0016755 ! aminoacyltransferase activity -is_a: GO:0140096 ! catalytic activity, acting on a protein -property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/24697" xsd:anyURI - [Term] id: GO:0019814 name: immunoglobulin complex @@ -62281,6 +61708,23 @@ intersection_of: results_in_assembly_of GO:1990904 ! ribonucleoprotein complex relationship: part_of GO:0022613 ! ribonucleoprotein complex biogenesis relationship: results_in_assembly_of GO:1990904 ! ribonucleoprotein complex +[Term] +id: GO:0022626 +name: cytosolic ribosome +namespace: cellular_component +alt_id: GO:0005830 +alt_id: GO:0009281 +alt_id: GO:0030871 +def: "A ribosome located in the cytosol." [GOC:mtg_sensu] +synonym: "70S ribosome" NARROW [] +synonym: "80S ribosome" NARROW [] +is_a: GO:0005840 ! ribosome +intersection_of: GO:0005840 ! ribosome +intersection_of: part_of GO:0005829 ! cytosol +relationship: in_taxon NCBITaxon:131567 {all_only="true"} ! cellular organisms +relationship: only_in_taxon NCBITaxon:131567 ! cellular organisms +relationship: part_of GO:0005829 ! cytosol + [Term] id: GO:0022803 name: passive transmembrane transporter activity @@ -62620,6 +62064,7 @@ subset: prokaryote_subset synonym: "cell projection organisation" EXACT [] synonym: "cell projection organization and biogenesis" RELATED [GOC:mah] synonym: "cell surface structure organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0008283 ! cell population proliferation is_a: GO:0016043 ! cellular component organization intersection_of: GO:0016043 ! cellular component organization intersection_of: results_in_organization_of GO:0042995 ! cell projection @@ -63708,21 +63153,6 @@ intersection_of: GO:0022411 ! cellular component disassembly intersection_of: results_in_disassembly_of GO:0016020 ! membrane relationship: results_in_disassembly_of GO:0016020 ! membrane -[Term] -id: GO:0030399 -name: autophagosome membrane disassembly -namespace: biological_process -def: "The controlled breakdown of the membranes of autophagosomes." [GOC:autophagy, GOC:mah] -synonym: "autophagic membrane breakdown" EXACT [] -synonym: "autophagic membrane catabolism" NARROW [GOC:autophagy] -synonym: "autophagic membrane degradation" NARROW [GOC:autophagy] -synonym: "autophagic vacuole membrane disassembly" EXACT [GOC:autophagy] -is_a: GO:0030397 ! membrane disassembly -is_a: GO:1905037 ! autophagosome organization -intersection_of: GO:0022411 ! cellular component disassembly -intersection_of: results_in_disassembly_of GO:0000421 ! autophagosome membrane -relationship: results_in_disassembly_of GO:0000421 ! autophagosome membrane - [Term] id: GO:0030421 name: defecation @@ -64546,6 +63976,15 @@ intersection_of: GO:0016043 ! cellular component organization intersection_of: results_in_organization_of GO:0042641 ! actomyosin relationship: results_in_organization_of GO:0042641 ! actomyosin +[Term] +id: GO:0031045 +name: dense core granule +namespace: cellular_component +def: "Electron-dense organelle with a granular internal matrix; contains proteins destined to be secreted." [NIF_Subcellular:sao772007592, PMID:14690495] +synonym: "dense core vesicle" EXACT syngo_official_label [GOC:kmv] +xref: NIF_Subcellular:sao772007592 +is_a: GO:0030141 ! secretory granule + [Term] id: GO:0031069 name: hair follicle morphogenesis @@ -65235,6 +64674,7 @@ namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections." [GOC:mah] synonym: "regulation of cell projection organisation" EXACT [] synonym: "regulation of cell projection organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0042127 ! regulation of cell population proliferation is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0030030 ! cell projection organization @@ -65251,6 +64691,7 @@ synonym: "downregulation of cell projection organization" EXACT [] synonym: "inhibition of cell projection organization" NARROW [] synonym: "negative regulation of cell projection organisation" EXACT [] synonym: "negative regulation of cell projection organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0008285 ! negative regulation of cell population proliferation is_a: GO:0031344 ! regulation of cell projection organization is_a: GO:0051129 ! negative regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation @@ -65269,6 +64710,7 @@ synonym: "stimulation of cell projection organization" NARROW [] synonym: "up regulation of cell projection organization" EXACT [] synonym: "up-regulation of cell projection organization" EXACT [] synonym: "upregulation of cell projection organization" EXACT [] +is_a: GO:0008284 ! positive regulation of cell population proliferation is_a: GO:0031344 ! regulation of cell projection organization is_a: GO:0051130 ! positive regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation @@ -65967,6 +65409,17 @@ intersection_of: GO:0022607 ! cellular component assembly intersection_of: results_in_assembly_of GO:0032059 ! bleb relationship: results_in_assembly_of GO:0032059 ! bleb +[Term] +id: GO:0032065 +name: maintenance of protein location in cell cortex +namespace: biological_process +def: "A process in which a protein or protein complex is maintained in a specific location in the cell cortex." [GOC:vw] +synonym: "cortical protein anchoring" RELATED [] +is_a: GO:0032507 ! maintenance of protein location in cell +intersection_of: GO:0045185 ! maintenance of protein location +intersection_of: occurs_in GO:0005938 ! cell cortex +relationship: occurs_in GO:0005938 ! cell cortex + [Term] id: GO:0032069 name: regulation of nuclease activity @@ -66150,6 +65603,18 @@ intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0009605 ! response to external stimulus relationship: positively_regulates GO:0009605 ! response to external stimulus +[Term] +id: GO:0032127 +name: dense core granule membrane +namespace: cellular_component +def: "The lipid bilayer surrounding a dense core granule." [GOC:mah] +synonym: "dense core vesicle membrane" EXACT [GOC:kmv] +is_a: GO:0030667 ! secretory granule membrane +intersection_of: GO:0016020 ! membrane +intersection_of: bounding_layer_of GO:0031045 ! dense core granule +relationship: bounding_layer_of GO:0031045 ! dense core granule +relationship: part_of GO:0031045 ! dense core granule + [Term] id: GO:0032222 name: regulation of synaptic transmission, cholinergic @@ -66376,6 +65841,19 @@ intersection_of: GO:0051179 ! localization intersection_of: has_primary_input GO:0030141 ! secretory granule relationship: has_primary_input GO:0030141 ! secretory granule +[Term] +id: GO:0032253 +name: dense core granule localization +namespace: biological_process +def: "Any process in which a dense core granule is transported to, and/or maintained in, a specific location within the cell." [GOC:mah] +synonym: "dense core granule clustering" RELATED [] +synonym: "dense core granule localisation" EXACT [GOC:mah] +synonym: "dense core vesicle localization" EXACT [GOC:kmv] +is_a: GO:0032252 ! secretory granule localization +intersection_of: GO:0051179 ! localization +intersection_of: has_primary_input GO:0031045 ! dense core granule +relationship: has_primary_input GO:0031045 ! dense core granule + [Term] id: GO:0032271 name: regulation of protein polymerization @@ -67257,6 +66735,19 @@ namespace: biological_process def: "The biological process in which new individuals are produced by one or two single-celled organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete] is_a: GO:0000003 ! reproduction +[Term] +id: GO:0032507 +name: maintenance of protein location in cell +namespace: biological_process +def: "Any process in which a protein is maintained in a specific location within, or in the membrane of, a cell, and is prevented from moving elsewhere." [GOC:isa_complete, GOC:mah] +synonym: "maintenance of protein localization in cell" RELATED [GOC:dph, GOC:tb] +is_a: GO:0045185 ! maintenance of protein location +is_a: GO:0051651 ! maintenance of location in cell +intersection_of: GO:0045185 ! maintenance of protein location +intersection_of: occurs_in CL:0000000 ! cell +relationship: in_taxon NCBITaxon:131567 {all_only="true"} ! cellular organisms +relationship: only_in_taxon NCBITaxon:131567 ! cellular organisms + [Term] id: GO:0032528 name: microvillus organization @@ -68452,51 +67943,12 @@ synonym: "RNA anabolism" EXACT [] synonym: "RNA biosynthesis" EXACT [] synonym: "RNA formation" EXACT [] synonym: "RNA synthesis" EXACT [] -is_a: GO:0009058 ! biosynthetic process +is_a: GO:0009059 ! macromolecule biosynthetic process is_a: GO:0016070 ! RNA metabolic process -intersection_of: GO:0009058 ! biosynthetic process +intersection_of: GO:0009059 ! macromolecule biosynthetic process intersection_of: has_primary_output CHEBI:33697 relationship: has_primary_output CHEBI:33697 -[Term] -id: GO:0032780 -name: negative regulation of ATP-dependent activity -namespace: biological_process -def: "Any process that stops or reduces the rate of an ATP-dependent activity." [GOC:mah] -subset: gocheck_do_not_annotate -synonym: "down regulation of ATPase activity" EXACT [] -synonym: "down-regulation of ATPase activity" EXACT [] -synonym: "downregulation of ATPase activity" EXACT [] -synonym: "inhibition of ATPase activity" NARROW [] -synonym: "negative regulation of adenosinetriphosphatase activity" EXACT [] -synonym: "negative regulation of ATPase activity" EXACT [] -is_a: GO:0043462 ! regulation of ATP-dependent activity -is_a: GO:0044092 ! negative regulation of molecular function -intersection_of: GO:0065007 ! biological regulation -intersection_of: negatively_regulates GO:0140657 ! ATP-dependent activity -relationship: negatively_regulates GO:0140657 ! ATP-dependent activity -property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/22371" xsd:anyURI - -[Term] -id: GO:0032781 -name: positive regulation of ATP-dependent activity -namespace: biological_process -def: "Any process that activates or increases the rate of an ATP-dependent activity." [GOC:mah] -subset: gocheck_do_not_annotate -synonym: "activation of ATPase activity" NARROW [] -synonym: "positive regulation of adenosinetriphosphatase activity" EXACT [] -synonym: "positive regulation of ATPase activity" EXACT [] -synonym: "stimulation of ATPase activity" NARROW [] -synonym: "up regulation of ATPase activity" EXACT [] -synonym: "up-regulation of ATPase activity" EXACT [] -synonym: "upregulation of ATPase activity" EXACT [] -is_a: GO:0043462 ! regulation of ATP-dependent activity -is_a: GO:0044093 ! positive regulation of molecular function -intersection_of: GO:0065007 ! biological regulation -intersection_of: positively_regulates GO:0140657 ! ATP-dependent activity -relationship: positively_regulates GO:0140657 ! ATP-dependent activity -property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/22371" xsd:anyURI - [Term] id: GO:0032782 name: bile acid secretion @@ -69377,6 +68829,58 @@ intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0030029 ! actin filament-based process relationship: regulates GO:0030029 ! actin filament-based process +[Term] +id: GO:0032973 +name: amino acid export across plasma membrane +namespace: biological_process +alt_id: GO:0044746 +def: "The directed movement of amino acids from inside of a cell, across the plasma membrane and into the extracellular region." [GOC:jl] +synonym: "amino acid efflux" EXACT [] +synonym: "amino acid export" BROAD [] +synonym: "amino acid transmembrane export" BROAD [] +is_a: GO:0003333 ! amino acid transmembrane transport +is_a: GO:0140115 ! export across plasma membrane +intersection_of: GO:0006810 ! transport +intersection_of: has_primary_input CHEBI:33709 +intersection_of: has_target_end_location GO:0005576 ! extracellular region +intersection_of: has_target_start_location GO:0005829 ! cytosol +intersection_of: results_in_transport_across GO:0005886 ! plasma membrane +created_by: jl +creation_date: 2012-11-14T14:27:40Z + +[Term] +id: GO:0032974 +name: amino acid transmembrane export from vacuole +namespace: biological_process +def: "The directed movement of amino acids out of the vacuole, across the vacuolar membrane." [GOC:mah] +synonym: "amino acid efflux from vacuole" EXACT [] +synonym: "vacuolar amino acid export" EXACT [] +is_a: GO:0003333 ! amino acid transmembrane transport +is_a: GO:0034486 ! vacuolar transmembrane transport +intersection_of: GO:0006810 ! transport +intersection_of: has_primary_input CHEBI:33709 +intersection_of: has_target_end_location GO:0005829 ! cytosol +intersection_of: has_target_start_location GO:0005775 ! vacuolar lumen +intersection_of: results_in_transport_across GO:0016020 ! membrane +relationship: has_target_end_location GO:0005829 ! cytosol +relationship: has_target_start_location GO:0005775 ! vacuolar lumen + +[Term] +id: GO:0032975 +name: amino acid transmembrane import into vacuole +namespace: biological_process +def: "The directed movement of amino acids into the vacuole across the vacuolar membrane." [GOC:mah] +synonym: "vacuolar amino acid import" EXACT [] +is_a: GO:0003333 ! amino acid transmembrane transport +is_a: GO:0034486 ! vacuolar transmembrane transport +intersection_of: GO:0006810 ! transport +intersection_of: has_primary_input CHEBI:33709 +intersection_of: has_target_end_location GO:0005775 ! vacuolar lumen +intersection_of: has_target_start_location GO:0005829 ! cytosol +intersection_of: results_in_transport_across GO:0016020 ! membrane +relationship: has_target_end_location GO:0005775 ! vacuolar lumen +relationship: has_target_start_location GO:0005829 ! cytosol + [Term] id: GO:0032980 name: keratinocyte activation @@ -71267,6 +70771,58 @@ intersection_of: has_primary_input CHEBI:33709 intersection_of: results_in_transport_across GO:0005774 ! vacuolar membrane relationship: results_in_transport_across GO:0005774 ! vacuolar membrane +[Term] +id: GO:0034488 +name: basic amino acid transmembrane export from vacuole +namespace: biological_process +def: "The directed movement of basic amino acids out of the vacuole, across the vacuolar membrane." [GOC:mah] +is_a: GO:0032974 ! amino acid transmembrane export from vacuole +is_a: GO:0034487 ! vacuolar amino acid transmembrane transport +is_a: GO:1990822 ! basic amino acid transmembrane transport +intersection_of: GO:0015802 ! basic amino acid transport +intersection_of: has_target_end_location GO:0005829 ! cytosol +intersection_of: has_target_start_location GO:0005775 ! vacuolar lumen +intersection_of: results_in_transport_across GO:0005774 ! vacuolar membrane + +[Term] +id: GO:0034489 +name: neutral amino acid transmembrane export from vacuole +namespace: biological_process +def: "The directed movement of neutral amino acids out of the vacuole, across the vacuolar membrane." [GOC:mah] +is_a: GO:0015804 ! neutral amino acid transport +is_a: GO:0032974 ! amino acid transmembrane export from vacuole +intersection_of: GO:0015804 ! neutral amino acid transport +intersection_of: has_primary_input CHEBI:33709 +intersection_of: has_target_end_location GO:0005829 ! cytosol +intersection_of: has_target_start_location GO:0005775 ! vacuolar lumen +intersection_of: results_in_transport_across GO:0016020 ! membrane + +[Term] +id: GO:0034490 +name: basic amino acid transmembrane import into vacuole +namespace: biological_process +def: "The directed movement of basic amino acids into the vacuole across the vacuolar membrane." [GOC:mah] +is_a: GO:0032975 ! amino acid transmembrane import into vacuole +is_a: GO:1990822 ! basic amino acid transmembrane transport +intersection_of: GO:0015802 ! basic amino acid transport +intersection_of: has_primary_input CHEBI:33709 +intersection_of: has_target_end_location GO:0005775 ! vacuolar lumen +intersection_of: has_target_start_location GO:0005829 ! cytosol +intersection_of: results_in_transport_across GO:0016020 ! membrane + +[Term] +id: GO:0034491 +name: neutral amino acid transmembrane import into vacuole +namespace: biological_process +def: "The directed movement of neutral amino acids into the vacuole across the vacuolar membrane." [GOC:mah] +is_a: GO:0015804 ! neutral amino acid transport +is_a: GO:0032975 ! amino acid transmembrane import into vacuole +intersection_of: GO:0015804 ! neutral amino acid transport +intersection_of: has_primary_input CHEBI:33709 +intersection_of: has_target_end_location GO:0005775 ! vacuolar lumen +intersection_of: has_target_start_location GO:0005829 ! cytosol +intersection_of: results_in_transport_across GO:0016020 ! membrane + [Term] id: GO:0034502 name: protein localization to chromosome @@ -71746,36 +71302,6 @@ intersection_of: results_in_acquisition_of_features_of CL:0002494 ! cardiocyte relationship: part_of GO:0007507 ! heart development relationship: results_in_acquisition_of_features_of CL:0002494 ! cardiocyte -[Term] -id: GO:0035070 -name: salivary gland histolysis -namespace: biological_process -def: "The stage-specific break down of the larval salivary glands during Drosophila metamorphosis, to allow replacement of larval structures by tissues and structures that form the adult fly." [GOC:bf, GOC:dph, GOC:mtg_apoptosis, PMID:9409683] -synonym: "salivary gland regression" EXACT [] -is_a: GO:0007435 ! salivary gland morphogenesis -is_a: GO:0009886 ! post-embryonic animal morphogenesis -is_a: GO:0060033 ! anatomical structure regression -intersection_of: GO:0060033 ! anatomical structure regression -intersection_of: results_in_morphogenesis_of UBERON:0001044 ! saliva-secreting gland -relationship: part_of GO:0007552 ! metamorphosis -relationship: part_of GO:0048707 ! instar larval or pupal morphogenesis - -[Term] -id: GO:0035071 -name: salivary gland cell autophagic cell death -namespace: biological_process -def: "The stage-specific programmed cell death of salivary gland cells during salivary gland histolysis." [GOC:bf, GOC:mtg_apoptosis, PMID:10882130] -synonym: "autophagic cell death of salivary gland cells" EXACT [] -synonym: "programmed cell death of salivary gland cells by autophagy" EXACT [] -synonym: "salivary gland cell death" EXACT [] -synonym: "salivary gland cell programmed cell death by autophagy" EXACT [] -is_a: GO:0010623 ! programmed cell death involved in cell development -is_a: GO:0048102 ! autophagic cell death -intersection_of: GO:0008219 ! cell death -intersection_of: results_in_maturation_of UBERON:0001044 ! saliva-secreting gland -relationship: part_of GO:0035070 ! salivary gland histolysis -relationship: results_in_maturation_of UBERON:0001044 ! saliva-secreting gland - [Term] id: GO:0035082 name: axoneme assembly @@ -72480,6 +72006,37 @@ relationship: part_of GO:0042582 ! azurophil granule created_by: bf creation_date: 2010-10-05T01:29:10Z +[Term] +id: GO:0035584 +name: calcium-mediated signaling using intracellular calcium source +namespace: biological_process +def: "The series of molecular signals in which a cell uses calcium ions released from an intracellular store to convert a signal into a response." [GOC:bf, GOC:BHF, PMID:20192754] +synonym: "calcium signaling using intracellular calcium source" EXACT [] +synonym: "calcium signalling using intracellular calcium source" EXACT [] +synonym: "calcium-mediated signalling using intracellular calcium source" EXACT [] +is_a: GO:0019722 ! calcium-mediated signaling +intersection_of: GO:0019722 ! calcium-mediated signaling +intersection_of: starts_with GO:0051209 ! release of sequestered calcium ion into cytosol +relationship: starts_with GO:0051209 ! release of sequestered calcium ion into cytosol +created_by: bf +creation_date: 2010-10-18T11:01:08Z + +[Term] +id: GO:0035585 +name: calcium-mediated signaling using extracellular calcium source +namespace: biological_process +def: "The series of molecular signals in which a cell uses calcium ions imported from an extracellular source to convert a signal into a response." [GOC:bf, GOC:BHF, PMID:20192754] +synonym: "calcium signaling using extracellular calcium source" EXACT [] +synonym: "calcium signalling using extracellular calcium source" EXACT [] +synonym: "calcium-mediated signalling using extracellular calcium source" EXACT [] +synonym: "extracellular calcium influx" NARROW [GOC:BHF] +is_a: GO:0019722 ! calcium-mediated signaling +intersection_of: GO:0019722 ! calcium-mediated signaling +intersection_of: starts_with GO:0098703 ! calcium ion import across plasma membrane +relationship: starts_with GO:0098703 ! calcium ion import across plasma membrane +created_by: bf +creation_date: 2010-10-18T11:04:27Z + [Term] id: GO:0035592 name: establishment of protein localization to extracellular region @@ -73808,6 +73365,17 @@ relationship: has_input CL:0000094 ! granulocyte created_by: bf creation_date: 2012-05-11T10:57:48Z +[Term] +id: GO:0036293 +name: response to decreased oxygen levels +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting a decline in the level of oxygen." [GOC:al] +comment: This term should be used when a decrease in oxygen levels is not considered a stress response. For a hypoxic stress response, consider instead 'response to hypoxia ; GO:0001666'. +synonym: "response to lowered oxygen levels" EXACT [GOC:bf] +is_a: GO:0070482 ! response to oxygen levels +created_by: bf +creation_date: 2012-07-20T01:05:46Z + [Term] id: GO:0036303 name: lymph vessel morphogenesis @@ -73924,7 +73492,7 @@ id: GO:0036344 name: platelet morphogenesis namespace: biological_process def: "Generation and organization of a platelet, a non-nucleated disk-shaped cell formed by extrusion from megakaryocytes, found in the blood of all mammals, and mainly involved in blood coagulation." [CL:0000233, GOC:BHF, GOC:vk] -is_a: GO:0000904 ! cell morphogenesis involved in differentiation +is_a: GO:0000902 ! cell morphogenesis created_by: bf creation_date: 2012-09-11T15:15:35Z @@ -74906,7 +74474,6 @@ namespace: biological_process def: "The chemical reactions and pathways involving neurotransmitters, any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell." [GOC:jl] subset: goslim_pir synonym: "neurotransmitter metabolism" EXACT [] -is_a: GO:0001505 ! regulation of neurotransmitter levels is_a: GO:0044237 ! cellular metabolic process relationship: never_in_taxon NCBITaxon:4895 ! Schizosaccharomyces @@ -75316,6 +74883,62 @@ subset: goslim_drosophila subset: goslim_pir is_a: GO:0032501 ! multicellular organismal process +[Term] +id: GO:0042306 +name: regulation of protein import into nucleus +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of movement of proteins from the cytoplasm to the nucleus." [GOC:jl] +synonym: "regulation of protein import into cell nucleus" EXACT [] +synonym: "regulation of protein transport from cytoplasm to nucleus" EXACT [] +synonym: "regulation of protein-nucleus import" EXACT [] +is_a: GO:0033157 ! regulation of intracellular protein transport +is_a: GO:0046822 ! regulation of nucleocytoplasmic transport +is_a: GO:1900180 ! regulation of protein localization to nucleus +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:0006606 ! protein import into nucleus +relationship: regulates GO:0006606 ! protein import into nucleus + +[Term] +id: GO:0042307 +name: positive regulation of protein import into nucleus +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of movement of proteins from the cytoplasm into the nucleus." [GOC:jl] +synonym: "activation of protein import into nucleus" NARROW [] +synonym: "positive regulation of protein import into cell nucleus" EXACT [] +synonym: "positive regulation of protein transport from cytoplasm to nucleus" EXACT [] +synonym: "positive regulation of protein-nucleus import" EXACT [] +synonym: "stimulation of protein import into nucleus" NARROW [] +synonym: "up regulation of protein import into nucleus" EXACT [] +synonym: "up-regulation of protein import into nucleus" EXACT [] +synonym: "upregulation of protein import into nucleus" EXACT [] +is_a: GO:0042306 ! regulation of protein import into nucleus +is_a: GO:0046824 ! positive regulation of nucleocytoplasmic transport +is_a: GO:0090316 ! positive regulation of intracellular protein transport +is_a: GO:1900182 ! positive regulation of protein localization to nucleus +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates GO:0006606 ! protein import into nucleus +relationship: positively_regulates GO:0006606 ! protein import into nucleus + +[Term] +id: GO:0042308 +name: negative regulation of protein import into nucleus +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of proteins from the cytoplasm into the nucleus." [GOC:jl] +synonym: "down regulation of protein import into nucleus" EXACT [] +synonym: "down-regulation of protein import into nucleus" EXACT [] +synonym: "downregulation of protein import into nucleus" EXACT [] +synonym: "inhibition of protein import into nucleus" NARROW [] +synonym: "negative regulation of protein import into cell nucleus" EXACT [] +synonym: "negative regulation of protein transport from cytoplasm to nucleus" EXACT [] +synonym: "negative regulation of protein-nucleus import" EXACT [] +is_a: GO:0042306 ! regulation of protein import into nucleus +is_a: GO:0046823 ! negative regulation of nucleocytoplasmic transport +is_a: GO:0090317 ! negative regulation of intracellular protein transport +is_a: GO:1900181 ! negative regulation of protein localization to nucleus +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:0006606 ! protein import into nucleus +relationship: negatively_regulates GO:0006606 ! protein import into nucleus + [Term] id: GO:0042325 name: regulation of phosphorylation @@ -76847,6 +76470,18 @@ intersection_of: GO:0016043 ! cellular component organization intersection_of: results_in_organization_of GO:0005576 ! extracellular region relationship: results_in_organization_of GO:0005576 ! extracellular region +[Term] +id: GO:0043063 +name: intercellular bridge organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the intracellular bridge. An intracellular bridge is a direct link between the cytoplasms of sister cells that allows cells to communicate with one another." [GOC:jid] +synonym: "intercellular bridge organisation" EXACT [] +synonym: "intercellular bridge organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0043062 ! extracellular structure organization +intersection_of: GO:0016043 ! cellular component organization +intersection_of: results_in_organization_of GO:0045171 ! intercellular bridge +relationship: results_in_organization_of GO:0045171 ! intercellular bridge + [Term] id: GO:0043065 name: positive regulation of apoptotic process @@ -78444,20 +78079,6 @@ intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0019748 ! secondary metabolic process relationship: regulates GO:0019748 ! secondary metabolic process -[Term] -id: GO:0043462 -name: regulation of ATP-dependent activity -namespace: biological_process -def: "Any process that modulates the rate of an ATP-dependent activity." [GOC:jl] -subset: gocheck_do_not_annotate -synonym: "regulation of adenosinetriphosphatase activity" EXACT [] -synonym: "regulation of ATPase activity" EXACT [] -is_a: GO:0065009 ! regulation of molecular function -intersection_of: GO:0065007 ! biological regulation -intersection_of: regulates GO:0140657 ! ATP-dependent activity -relationship: regulates GO:0140657 ! ATP-dependent activity -property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/22371" xsd:anyURI - [Term] id: GO:0043467 name: regulation of generation of precursor metabolites and energy @@ -78537,7 +78158,6 @@ synonym: "regulation of neuronal cell programmed cell death" EXACT [] synonym: "regulation of programmed cell death of neuronal cells" EXACT [] synonym: "regulation of programmed cell death, neurons" EXACT [] is_a: GO:0042981 ! regulation of apoptotic process -is_a: GO:1901214 ! regulation of neuron death intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0051402 ! neuron apoptotic process relationship: regulates GO:0051402 ! neuron apoptotic process @@ -78556,7 +78176,6 @@ synonym: "negative regulation of programmed cell death, neurons" EXACT [] synonym: "neuron survival" NARROW [] is_a: GO:0043066 ! negative regulation of apoptotic process is_a: GO:0043523 ! regulation of neuron apoptotic process -is_a: GO:1901215 ! negative regulation of neuron death intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0051402 ! neuron apoptotic process relationship: negatively_regulates GO:0051402 ! neuron apoptotic process @@ -78575,7 +78194,6 @@ synonym: "up-regulation of neuron apoptosis" EXACT [] synonym: "upregulation of neuron apoptosis" EXACT [] is_a: GO:0043065 ! positive regulation of apoptotic process is_a: GO:0043523 ! regulation of neuron apoptotic process -is_a: GO:1901216 ! positive regulation of neuron death intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0051402 ! neuron apoptotic process relationship: positively_regulates GO:0051402 ! neuron apoptotic process @@ -79221,6 +78839,18 @@ subset: goslim_pir synonym: "primary metabolism" EXACT [] is_a: GO:0008152 ! metabolic process +[Term] +id: GO:0044242 +name: cellular lipid catabolic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the breakdown of lipids, as carried out by individual cells." [GOC:jl] +synonym: "cellular lipid breakdown" EXACT [] +synonym: "cellular lipid catabolism" EXACT [] +synonym: "cellular lipid degradation" EXACT [] +is_a: GO:0016042 ! lipid catabolic process +is_a: GO:0044248 ! cellular catabolic process +is_a: GO:0044255 ! cellular lipid metabolic process + [Term] id: GO:0044248 name: cellular catabolic process @@ -79244,6 +78874,16 @@ synonym: "cellular synthesis" EXACT [] is_a: GO:0009058 ! biosynthetic process is_a: GO:0044237 ! cellular metabolic process +[Term] +id: GO:0044255 +name: cellular lipid metabolic process +namespace: biological_process +def: "The chemical reactions and pathways involving lipids, as carried out by individual cells." [GOC:jl] +subset: goslim_pir +synonym: "cellular lipid metabolism" EXACT [] +is_a: GO:0006629 ! lipid metabolic process +is_a: GO:0044237 ! cellular metabolic process + [Term] id: GO:0044258 name: intestinal lipid catabolic process @@ -79339,12 +78979,12 @@ creation_date: 2010-02-05T10:37:16Z id: GO:0044302 name: dentate gyrus mossy fiber namespace: cellular_component -def: "Distinctive, unmyelinated axons produced by granule cells." [NIF_Subcellular:nlx_subcell_20090601, PMID:17765709] +def: "Distinctive, unmyelinated axons produced by dentate gyrus granule cells." [NIF_Subcellular:nlx_subcell_20090601, PMID:17765709] synonym: "dentate gyrus mossy fibre" EXACT [] -synonym: "granule cell axon" EXACT [] +synonym: "granule cell axon" BROAD [] xref: NIF_Subcellular:nlx_subcell_20090601 is_a: GO:0030424 ! axon -relationship: part_of CL:0000120 ! granule cell +relationship: part_of CL:2000089 ! dentate gyrus granule cell created_by: jl creation_date: 2010-02-05T11:23:55Z @@ -79490,6 +79130,24 @@ property_value: term_tracker_item "https://github.com/geneontology/go-ontology/i created_by: jl creation_date: 2012-09-19T16:06:16Z +[Term] +id: GO:0044743 +name: protein transmembrane import into intracellular organelle +namespace: biological_process +def: "The directed movement of proteins into an intracellular organelle, across a membrane." [GOC:jl] +is_a: GO:0071806 ! protein transmembrane transport +is_a: GO:0072594 ! establishment of protein localization to organelle +intersection_of: GO:0006810 ! transport +intersection_of: has_primary_input PR:000000001 ! protein +intersection_of: has_target_end_location GO:0043229 ! intracellular organelle +intersection_of: has_target_start_location GO:0005829 ! cytosol +intersection_of: results_in_transport_across GO:0031090 ! organelle membrane +relationship: has_target_end_location GO:0043229 ! intracellular organelle +relationship: has_target_start_location GO:0005829 ! cytosol +relationship: results_in_transport_across GO:0031090 ! organelle membrane +created_by: jl +creation_date: 2012-11-07T15:37:36Z + [Term] id: GO:0044782 name: cilium organization @@ -79509,20 +79167,6 @@ relationship: results_in_organization_of GO:0005929 ! cilium created_by: jl creation_date: 2013-03-27T15:09:58Z -[Term] -id: GO:0044804 -name: nucleophagy -namespace: biological_process -def: "A form of autophagy, by which damaged or non-essential parts of the nucleus, or even an entire nucleus is degraded." [GOC:autophagy, GOC:jl, PMID:24013549] -synonym: "autophagy of nucleus" EXACT [] -synonym: "nucleus degradation" RELATED [] -is_a: GO:0006914 ! autophagy -intersection_of: GO:0006914 ! autophagy -intersection_of: has_input GO:0005634 ! nucleus -relationship: has_input GO:0005634 ! nucleus -created_by: jl -creation_date: 2013-09-10T15:50:25Z - [Term] id: GO:0044872 name: lipoprotein localization @@ -79890,6 +79534,22 @@ intersection_of: GO:0007267 ! cell-cell signaling intersection_of: part_of GO:0045165 ! cell fate commitment relationship: part_of GO:0045165 ! cell fate commitment +[Term] +id: GO:0045171 +name: intercellular bridge +namespace: cellular_component +def: "A direct connection between the cytoplasm of two cells that is formed following the completion of cleavage furrow ingression during cell division. They are usually present only briefly prior to completion of cytokinesis. However, in some cases, such as the bridges between germ cells during their development, they become stabilised." [PMID:9635420] +is_a: GO:0110165 ! cellular anatomical entity + +[Term] +id: GO:0045172 +name: germline ring canal +namespace: cellular_component +def: "Germline specific intercellular bridge. During cyst formation in insects, ring canals interconnect the cells of the cyst, facilitating the passage of cytoplasmic components between cells." [GOC:mtg_sensu, PMID:9635420, PMID:9655801] +is_a: GO:0045171 ! intercellular bridge +relationship: in_taxon NCBITaxon:6656 {all_only="true"} ! Arthropoda +relationship: only_in_taxon NCBITaxon:6656 ! Arthropoda + [Term] id: GO:0045184 name: establishment of protein localization @@ -79903,6 +79563,18 @@ is_a: GO:0051234 ! establishment of localization intersection_of: GO:0051234 ! establishment of localization intersection_of: has_primary_input CHEBI:36080 +[Term] +id: GO:0045185 +name: maintenance of protein location +namespace: biological_process +def: "Any process in which a protein is maintained in a location and prevented from moving elsewhere. These include sequestration, stabilization to prevent transport elsewhere and the active retrieval of proteins that do move away." [GOC:bf] +synonym: "active protein retrieval" NARROW [] +synonym: "maintenance of protein localization" RELATED [GOC:dph, GOC:tb] +synonym: "protein retention" NARROW [] +synonym: "protein sequestering" NARROW [] +is_a: GO:0051235 ! maintenance of location +relationship: part_of GO:0008104 ! protein localization + [Term] id: GO:0045190 name: isotype switching @@ -82263,7 +81935,6 @@ synonym: "up-regulation of glycogen biosynthetic process" EXACT [] synonym: "upregulation of glycogen biosynthetic process" EXACT [] is_a: GO:0005979 ! regulation of glycogen biosynthetic process is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process -is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0070875 ! positive regulation of glycogen metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0005978 ! glycogen biosynthetic process @@ -82286,7 +81957,6 @@ synonym: "up regulation of protein biosynthetic process" EXACT [] synonym: "up-regulation of protein biosynthetic process" EXACT [] synonym: "upregulation of protein biosynthetic process" EXACT [] is_a: GO:0006417 ! regulation of translation -is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process is_a: GO:0010628 ! positive regulation of gene expression is_a: GO:0051247 ! positive regulation of protein metabolic process intersection_of: GO:0065007 ! biological regulation @@ -83499,7 +83169,6 @@ synonym: "downregulation of translational initiation" EXACT [] synonym: "inhibition of translational initiation" NARROW [] is_a: GO:0006446 ! regulation of translational initiation is_a: GO:0017148 ! negative regulation of translation -is_a: GO:0031324 ! negative regulation of cellular metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0006413 ! translational initiation relationship: negatively_regulates GO:0006413 ! translational initiation @@ -83515,7 +83184,6 @@ synonym: "up regulation of translational initiation" EXACT [] synonym: "up-regulation of translational initiation" EXACT [] synonym: "upregulation of translational initiation" EXACT [] is_a: GO:0006446 ! regulation of translational initiation -is_a: GO:0031325 ! positive regulation of cellular metabolic process is_a: GO:0045727 ! positive regulation of translation intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0006413 ! translational initiation @@ -84889,6 +84557,207 @@ intersection_of: results_in_assembly_of GO:0005874 ! microtubule relationship: results_in_assembly_of GO:0005874 ! microtubule relationship: starts_with GO:0007020 ! microtubule nucleation +[Term] +id: GO:0046822 +name: regulation of nucleocytoplasmic transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of substances between the nucleus and the cytoplasm." [GOC:bf] +is_a: GO:0032386 ! regulation of intracellular transport +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:0006913 ! nucleocytoplasmic transport +relationship: regulates GO:0006913 ! nucleocytoplasmic transport + +[Term] +id: GO:0046823 +name: negative regulation of nucleocytoplasmic transport +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances between the cytoplasm and the nucleus." [GOC:bf] +synonym: "down regulation of nucleocytoplasmic transport" EXACT [] +synonym: "down-regulation of nucleocytoplasmic transport" EXACT [] +synonym: "downregulation of nucleocytoplasmic transport" EXACT [] +synonym: "inhibition of nucleocytoplasmic transport" NARROW [] +is_a: GO:0032387 ! negative regulation of intracellular transport +is_a: GO:0046822 ! regulation of nucleocytoplasmic transport +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:0006913 ! nucleocytoplasmic transport +relationship: negatively_regulates GO:0006913 ! nucleocytoplasmic transport + +[Term] +id: GO:0046824 +name: positive regulation of nucleocytoplasmic transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the directed movement of substances between the nucleus and the cytoplasm." [GOC:bf] +synonym: "activation of nucleocytoplasmic transport" NARROW [] +synonym: "stimulation of nucleocytoplasmic transport" NARROW [] +synonym: "up regulation of nucleocytoplasmic transport" EXACT [] +synonym: "up-regulation of nucleocytoplasmic transport" EXACT [] +synonym: "upregulation of nucleocytoplasmic transport" EXACT [] +is_a: GO:0032388 ! positive regulation of intracellular transport +is_a: GO:0046822 ! regulation of nucleocytoplasmic transport +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates GO:0006913 ! nucleocytoplasmic transport +relationship: positively_regulates GO:0006913 ! nucleocytoplasmic transport + +[Term] +id: GO:0046825 +name: regulation of protein export from nucleus +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of proteins from the nucleus to the cytoplasm." [GOC:bf] +synonym: "regulation of protein export from cell nucleus" EXACT [] +synonym: "regulation of protein export out of nucleus" EXACT [] +synonym: "regulation of protein transport from nucleus to cytoplasm" EXACT [] +synonym: "regulation of protein-nucleus export" EXACT [] +is_a: GO:0033157 ! regulation of intracellular protein transport +is_a: GO:0046822 ! regulation of nucleocytoplasmic transport +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:0006611 ! protein export from nucleus +relationship: regulates GO:0006611 ! protein export from nucleus + +[Term] +id: GO:0046826 +name: negative regulation of protein export from nucleus +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of proteins from the nucleus into the cytoplasm." [GOC:bf] +synonym: "down regulation of protein export from nucleus" EXACT [] +synonym: "down-regulation of protein export from nucleus" EXACT [] +synonym: "downregulation of protein export from nucleus" EXACT [] +synonym: "inhibition of protein export from nucleus" NARROW [] +synonym: "negative regulation of protein export from cell nucleus" EXACT [] +synonym: "negative regulation of protein export out of nucleus" EXACT [] +synonym: "negative regulation of protein transport from nucleus to cytoplasm" EXACT [] +synonym: "negative regulation of protein-nucleus export" EXACT [] +is_a: GO:0046823 ! negative regulation of nucleocytoplasmic transport +is_a: GO:0046825 ! regulation of protein export from nucleus +is_a: GO:0051457 ! maintenance of protein location in nucleus +is_a: GO:0090317 ! negative regulation of intracellular protein transport +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:0006611 ! protein export from nucleus +relationship: negatively_regulates GO:0006611 ! protein export from nucleus + +[Term] +id: GO:0046827 +name: positive regulation of protein export from nucleus +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of directed movement of proteins from the nucleus into the cytoplasm." [GOC:bf] +synonym: "activation of protein export from nucleus" NARROW [] +synonym: "positive regulation of protein export from cell nucleus" EXACT [] +synonym: "positive regulation of protein export out of nucleus" EXACT [] +synonym: "positive regulation of protein transport from nucleus to cytoplasm" EXACT [] +synonym: "positive regulation of protein-nucleus export" EXACT [] +synonym: "stimulation of protein export from nucleus" NARROW [] +synonym: "up regulation of protein export from nucleus" EXACT [] +synonym: "up-regulation of protein export from nucleus" EXACT [] +synonym: "upregulation of protein export from nucleus" EXACT [] +is_a: GO:0046824 ! positive regulation of nucleocytoplasmic transport +is_a: GO:0046825 ! regulation of protein export from nucleus +is_a: GO:0090316 ! positive regulation of intracellular protein transport +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates GO:0006611 ! protein export from nucleus +relationship: positively_regulates GO:0006611 ! protein export from nucleus + +[Term] +id: GO:0046828 +name: regulation of RNA import into nucleus +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of movement of RNA from the cytoplasm to the nucleus." [GOC:bf] +synonym: "regulation of RNA import into cell nucleus" EXACT [] +synonym: "regulation of RNA transport from cytoplasm to nucleus" EXACT [] +synonym: "regulation of RNA-nucleus import" EXACT [] +is_a: GO:0046822 ! regulation of nucleocytoplasmic transport +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:0006404 ! RNA import into nucleus +relationship: regulates GO:0006404 ! RNA import into nucleus + +[Term] +id: GO:0046829 +name: negative regulation of RNA import into nucleus +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of RNA from the cytoplasm into the nucleus." [GOC:bf] +synonym: "down regulation of RNA import into nucleus" EXACT [] +synonym: "down-regulation of RNA import into nucleus" EXACT [] +synonym: "downregulation of RNA import into nucleus" EXACT [] +synonym: "inhibition of RNA import into nucleus" NARROW [] +synonym: "negative regulation of RNA import into cell nucleus" EXACT [] +synonym: "negative regulation of RNA transport from cytoplasm to nucleus" EXACT [] +synonym: "negative regulation of RNA-nucleus import" EXACT [] +is_a: GO:0046823 ! negative regulation of nucleocytoplasmic transport +is_a: GO:0046828 ! regulation of RNA import into nucleus +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:0006404 ! RNA import into nucleus +relationship: negatively_regulates GO:0006404 ! RNA import into nucleus + +[Term] +id: GO:0046830 +name: positive regulation of RNA import into nucleus +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of movement of RNA from the cytoplasm into the nucleus." [GOC:bf] +synonym: "activation of RNA import into nucleus" NARROW [] +synonym: "positive regulation of RNA import into cell nucleus" EXACT [] +synonym: "positive regulation of RNA transport from cytoplasm to nucleus" EXACT [] +synonym: "positive regulation of RNA-nucleus import" EXACT [] +synonym: "stimulation of RNA import into nucleus" NARROW [] +synonym: "up regulation of RNA import into nucleus" EXACT [] +synonym: "up-regulation of RNA import into nucleus" EXACT [] +synonym: "upregulation of RNA import into nucleus" EXACT [] +is_a: GO:0046824 ! positive regulation of nucleocytoplasmic transport +is_a: GO:0046828 ! regulation of RNA import into nucleus +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates GO:0006404 ! RNA import into nucleus +relationship: positively_regulates GO:0006404 ! RNA import into nucleus + +[Term] +id: GO:0046831 +name: regulation of RNA export from nucleus +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of RNA from the nucleus to the cytoplasm." [GOC:bf] +synonym: "regulation of RNA export from cell nucleus" EXACT [] +synonym: "regulation of RNA export out of nucleus" EXACT [] +synonym: "regulation of RNA transport from nucleus to cytoplasm" EXACT [] +synonym: "regulation of RNA-nucleus export" EXACT [] +is_a: GO:0046822 ! regulation of nucleocytoplasmic transport +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:0006405 ! RNA export from nucleus +relationship: regulates GO:0006405 ! RNA export from nucleus + +[Term] +id: GO:0046832 +name: negative regulation of RNA export from nucleus +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of RNA from the nucleus into the cytoplasm." [GOC:bf] +synonym: "down regulation of RNA export from nucleus" EXACT [] +synonym: "down-regulation of RNA export from nucleus" EXACT [] +synonym: "downregulation of RNA export from nucleus" EXACT [] +synonym: "inhibition of RNA export from nucleus" NARROW [] +synonym: "negative regulation of RNA export from cell nucleus" EXACT [] +synonym: "negative regulation of RNA export out of nucleus" EXACT [] +synonym: "negative regulation of RNA transport from nucleus to cytoplasm" EXACT [] +synonym: "negative regulation of RNA-nucleus export" EXACT [] +is_a: GO:0046823 ! negative regulation of nucleocytoplasmic transport +is_a: GO:0046831 ! regulation of RNA export from nucleus +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:0006405 ! RNA export from nucleus +relationship: negatively_regulates GO:0006405 ! RNA export from nucleus + +[Term] +id: GO:0046833 +name: positive regulation of RNA export from nucleus +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of directed movement of RNA from the nucleus into the cytoplasm." [GOC:bf] +synonym: "activation of RNA export from nucleus" NARROW [] +synonym: "positive regulation of RNA export from cell nucleus" EXACT [] +synonym: "positive regulation of RNA export out of nucleus" EXACT [] +synonym: "positive regulation of RNA transport from nucleus to cytoplasm" EXACT [] +synonym: "positive regulation of RNA-nucleus export" EXACT [] +synonym: "stimulation of RNA export from nucleus" NARROW [] +synonym: "up regulation of RNA export from nucleus" EXACT [] +synonym: "up-regulation of RNA export from nucleus" EXACT [] +synonym: "upregulation of RNA export from nucleus" EXACT [] +is_a: GO:0046824 ! positive regulation of nucleocytoplasmic transport +is_a: GO:0046831 ! regulation of RNA export from nucleus +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates GO:0006405 ! RNA export from nucleus +relationship: positively_regulates GO:0006405 ! RNA export from nucleus + [Term] id: GO:0046848 name: hydroxyapatite binding @@ -85274,24 +85143,6 @@ intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0048066 ! developmental pigmentation relationship: positively_regulates GO:0048066 ! developmental pigmentation -[Term] -id: GO:0048102 -name: autophagic cell death -namespace: biological_process -def: "A form of programmed cell death that is accompanied by the formation of autophagosomes. Autophagic cell death is characterized by lack of chromatin condensation and massive vacuolization of the cytoplasm, with little or no uptake by phagocytic cells." [GOC:autophagy, GOC:mah, GOC:mtg_apoptosis, PMID:18846107, PMID:23347517] -comment: The precise nature of autophagic cell death is still being debated, and the link between autophagy and cell death unclear. As autophagy is often induced under conditions of stress that could also lead to cell death, there has been a propagation of the idea that autophagy can act as a cell death mechanism; but others suggest that autophagy may simply be an attempt of dying cells to adapt to lethal stress rather than a mechanism to execute a cell death program. Further studies are required to resolve this controversy (see e.g. PMID:22082964, PMID:22052193, PMID:25236395). In the meantime, curators should carefully examine the experimental evidence presented in papers concerning autophagic cell death, and annotate accordingly. Recently, an instance of autophagic cell death, termed autosis, was discovered that relies on the plasma membrane Na+/K+-ATPase. Autosis was observed in vivo in the brain of rats subjected to an ischemic insult. It's still unclear if all cases of autophagic cell death require the Na+/K+-ATPase or not. -synonym: "autophagic death" BROAD [] -synonym: "autosis" RELATED [PMID:25236395] -synonym: "programmed cell death by autophagy" BROAD [GOC:pr] -synonym: "programmed cell death by macroautophagy" EXACT [GOC:cjm] -synonym: "type II programmed cell death" RELATED [GOC:sl] -is_a: GO:0012501 ! programmed cell death -intersection_of: GO:0012501 ! programmed cell death -intersection_of: has_part GO:0016236 ! macroautophagy -relationship: has_part GO:0016236 ! macroautophagy -relationship: in_taxon NCBITaxon:2759 {all_only="true"} ! Eukaryota -relationship: only_in_taxon NCBITaxon:2759 ! Eukaryota - [Term] id: GO:0048103 name: somatic stem cell division @@ -85912,8 +85763,8 @@ namespace: biological_process def: "The cellular developmental process, independent of morphogenetic (shape) change, that is required for a specific cell to attain its fully functional state." [GOC:go_curators] subset: goslim_pir synonym: "functional differentiation" RELATED [GOC:dph] -is_a: GO:0021700 ! developmental maturation is_a: GO:0048869 ! cellular developmental process +is_a: GO:0071695 ! anatomical structure maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: results_in_maturation_of CL:0000000 ! cell relationship: part_of GO:0048468 ! cell development @@ -86507,7 +86358,7 @@ name: oocyte morphogenesis namespace: biological_process def: "The process in which the structures of an oocyte are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of an oocyte." [GOC:go_curators] synonym: "oocyte morphogenesis during differentiation" EXACT [] -is_a: GO:0000904 ! cell morphogenesis involved in differentiation +is_a: GO:0000902 ! cell morphogenesis is_a: GO:0003006 ! developmental process involved in reproduction intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: results_in_morphogenesis_of CL:0000023 ! oocyte @@ -86854,7 +86705,7 @@ name: cell morphogenesis involved in neuron differentiation namespace: biological_process def: "The process in which the structures of a neuron are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a neuron." [GOC:dph, GOC:tb] synonym: "neuron morphogenesis involved in differentiation" EXACT [GOC:dph, GOC:tb] -is_a: GO:0000904 ! cell morphogenesis involved in differentiation +is_a: GO:0000902 ! cell morphogenesis intersection_of: GO:0000902 ! cell morphogenesis intersection_of: part_of GO:0030182 ! neuron differentiation relationship: part_of GO:0048666 ! neuron development @@ -88277,8 +88128,8 @@ id: GO:0048938 name: lateral line nerve glial cell morphogenesis involved in differentiation namespace: biological_process def: "The process in which the structure of a glial cell in a lateral line nerve is generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a glial cell in a lateral line nerve." [GOC:dgh] -is_a: GO:0000904 ! cell morphogenesis involved in differentiation -intersection_of: GO:0000904 ! cell morphogenesis involved in differentiation +is_a: GO:0000902 ! cell morphogenesis +intersection_of: GO:0000902 ! cell morphogenesis intersection_of: part_of GO:0048937 ! lateral line nerve glial cell development relationship: part_of GO:0048937 ! lateral line nerve glial cell development relationship: results_in_morphogenesis_of CL:1000050 ! lateral line nerve glial cell @@ -88300,7 +88151,7 @@ name: anterior lateral line nerve glial cell morphogenesis involved in different namespace: biological_process def: "The process in which the structures of a glial cell in the anterior lateral line nerve are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a glial cell in the anterior lateral line nerve." [GOC:dgh] is_a: GO:0048938 ! lateral line nerve glial cell morphogenesis involved in differentiation -intersection_of: GO:0000904 ! cell morphogenesis involved in differentiation +intersection_of: GO:0000902 ! cell morphogenesis intersection_of: part_of GO:0048939 ! anterior lateral line nerve glial cell development relationship: part_of GO:0048939 ! anterior lateral line nerve glial cell development @@ -88321,7 +88172,7 @@ name: posterior lateral line nerve glial cell morphogenesis involved in differen namespace: biological_process def: "The process in which the structures of a glial cell in the posterior lateral line nerve are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a glial cell in the posterior lateral line nerve." [GOC:dgh] is_a: GO:0048938 ! lateral line nerve glial cell morphogenesis involved in differentiation -intersection_of: GO:0000904 ! cell morphogenesis involved in differentiation +intersection_of: GO:0000902 ! cell morphogenesis intersection_of: part_of GO:0048941 ! posterior lateral line nerve glial cell development relationship: part_of GO:0048941 ! posterior lateral line nerve glial cell development @@ -88915,7 +88766,7 @@ synonym: "stimulation of dendrite morphogenesis" NARROW [] synonym: "up regulation of dendrite morphogenesis" EXACT [] synonym: "up-regulation of dendrite morphogenesis" EXACT [] synonym: "upregulation of dendrite morphogenesis" EXACT [] -is_a: GO:0010770 ! positive regulation of cell morphogenesis involved in differentiation +is_a: GO:0010770 ! positive regulation of cell morphogenesis is_a: GO:0031346 ! positive regulation of cell projection organization is_a: GO:0048814 ! regulation of dendrite morphogenesis is_a: GO:0050769 ! positive regulation of neurogenesis @@ -91051,6 +90902,22 @@ intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0051146 ! striated muscle cell differentiation relationship: positively_regulates GO:0051146 ! striated muscle cell differentiation +[Term] +id: GO:0051168 +name: nuclear export +namespace: biological_process +def: "The directed movement of substances out of the nucleus." [GOC:ai] +synonym: "export from nucleus" EXACT [] +synonym: "nucleus export" EXACT [] +synonym: "substance nuclear export" EXACT [] +is_a: GO:0006913 ! nucleocytoplasmic transport +intersection_of: GO:0006810 ! transport +intersection_of: has_target_end_location GO:0005829 ! cytosol +intersection_of: has_target_start_location GO:0031981 ! nuclear lumen +intersection_of: results_in_transport_across GO:0005635 ! nuclear envelope +relationship: has_target_end_location GO:0005829 ! cytosol +relationship: has_target_start_location GO:0031981 ! nuclear lumen + [Term] id: GO:0051169 name: nuclear transport @@ -91065,6 +90932,24 @@ intersection_of: occurs_in GO:0005622 ! intracellular anatomical structure intersection_of: results_in_transport_to_from_or_in GO:0005634 ! nucleus relationship: results_in_transport_to_from_or_in GO:0005634 ! nucleus +[Term] +id: GO:0051170 +name: import into nucleus +namespace: biological_process +alt_id: GO:1902593 +def: "The directed movement of substances into the nucleus." [GOC:ai] +synonym: "nuclear import" EXACT [] +synonym: "nuclear translocation" EXACT [] +is_a: GO:0006913 ! nucleocytoplasmic transport +intersection_of: GO:0006810 ! transport +intersection_of: has_target_end_location GO:0031981 ! nuclear lumen +intersection_of: has_target_start_location GO:0005829 ! cytosol +intersection_of: results_in_transport_across GO:0005635 ! nuclear envelope +relationship: has_target_end_location GO:0031981 ! nuclear lumen +relationship: has_target_start_location GO:0005829 ! cytosol +created_by: jl +creation_date: 2013-12-19T15:26:34Z + [Term] id: GO:0051171 name: regulation of nitrogen compound metabolic process @@ -91131,6 +91016,52 @@ is_a: GO:0008150 ! biological_process created_by: jl creation_date: 2013-12-18T13:51:04Z +[Term] +id: GO:0051208 +name: sequestering of calcium ion +namespace: biological_process +def: "The process of binding or confining calcium ions such that they are separated from other components of a biological system." [GOC:ai] +synonym: "calcium ion (Ca2+) retention" EXACT [] +synonym: "calcium ion (Ca2+) sequestering" EXACT [] +synonym: "calcium ion (Ca2+) sequestration" EXACT [] +synonym: "calcium ion (Ca2+) storage" EXACT [] +synonym: "calcium ion storage activity" RELATED [] +synonym: "negative regulation of calcium ion (Ca2+) transport" RELATED [] +synonym: "retention of calcium ion (Ca2+)" EXACT [] +synonym: "sequestering of calcium ion (Ca2+)" EXACT [] +synonym: "sequestration of calcium ion (Ca2+)" EXACT [] +synonym: "storage of calcium ion (Ca2+)" EXACT [] +is_a: GO:0051651 ! maintenance of location in cell +intersection_of: GO:0051235 ! maintenance of location +intersection_of: has_primary_input CHEBI:39124 +relationship: has_primary_input CHEBI:39124 +relationship: part_of GO:0006874 ! intracellular calcium ion homeostasis + +[Term] +id: GO:0051209 +name: release of sequestered calcium ion into cytosol +namespace: biological_process +def: "The process in which calcium ions sequestered in the endoplasmic reticulum, Golgi apparatus or mitochondria are released into the cytosolic compartment." [GOC:dph, GOC:hjd, GOC:mtg_lung, PMID:1814929] +synonym: "calcium ion (Ca2+) mobilization" BROAD [] +synonym: "calcium mobilization" BROAD [] +synonym: "cytoplasmic release of sequestered calcium ion (Ca2+)" BROAD [] +synonym: "cytoplasmic release of stored calcium ion (Ca2+)" BROAD [] +synonym: "cytosolic release of sequestered calcium ion (Ca2+)" EXACT [] +synonym: "cytosolic release of stored calcium ion (Ca2+)" EXACT [] +synonym: "release of sequestered calcium ion (Ca2+)" BROAD [] +synonym: "release of sequestered calcium ion into cytoplasm" BROAD [] +synonym: "release of stored calcium ion (Ca2+)" BROAD [] +synonym: "release of stored calcium ion (Ca2+) into cytoplasm" BROAD [] +synonym: "release of stored calcium ion (Ca2+) into cytosol" EXACT [] +is_a: GO:0051283 ! negative regulation of sequestering of calcium ion +is_a: GO:0097553 ! calcium ion transmembrane import into cytosol +intersection_of: GO:0006810 ! transport +intersection_of: has_primary_input CHEBI:29108 +intersection_of: has_target_end_location GO:0005829 ! cytosol +intersection_of: has_target_start_location GO:0043231 ! intracellular membrane-bounded organelle +intersection_of: results_in_transport_across GO:0016020 ! membrane +relationship: has_target_start_location GO:0043231 ! intracellular membrane-bounded organelle + [Term] id: GO:0051216 name: cartilage development @@ -91206,6 +91137,17 @@ subset: goslim_pir synonym: "establishment of localisation" EXACT [GOC:mah] is_a: GO:0051179 ! localization +[Term] +id: GO:0051235 +name: maintenance of location +namespace: biological_process +def: "Any process in which a cell, substance or cellular entity, such as a protein complex or organelle, is maintained in a location and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb] +synonym: "maintenance of localization" EXACT [] +synonym: "retention" NARROW [] +synonym: "sequestering" NARROW [] +synonym: "storage" NARROW [] +is_a: GO:0051179 ! localization + [Term] id: GO:0051236 name: establishment of RNA localization @@ -91455,6 +91397,145 @@ relationship: results_in_organization_of GO:0005694 ! chromosome property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/22811" xsd:anyURI property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/4585" xsd:anyURI +[Term] +id: GO:0051279 +name: regulation of release of sequestered calcium ion into cytosol +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the release into the cytosolic compartment of calcium ions sequestered in the endoplasmic reticulum or mitochondria." [GOC:ai, GOC:tb] +synonym: "regulation of calcium ion (Ca2+) mobilization" EXACT [] +synonym: "regulation of calcium mobilization" EXACT [] +synonym: "regulation of cytoplasmic release of sequestered calcium ion (Ca2+)" EXACT [] +synonym: "regulation of cytoplasmic release of stored calcium ion (Ca2+)" EXACT [] +synonym: "regulation of release of sequestered calcium ion (Ca2+)" BROAD [] +synonym: "regulation of release of stored calcium ion (Ca2+)" BROAD [] +synonym: "regulation of release of stored calcium ion (Ca2+) into cytoplasm" EXACT [] +synonym: "regulation of release of stored calcium ion (Ca2+) into cytosol" EXACT [] +is_a: GO:0051282 ! regulation of sequestering of calcium ion +is_a: GO:1903169 ! regulation of calcium ion transmembrane transport +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:0051209 ! release of sequestered calcium ion into cytosol +relationship: regulates GO:0051209 ! release of sequestered calcium ion into cytosol + +[Term] +id: GO:0051280 +name: negative regulation of release of sequestered calcium ion into cytosol +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the release into the cytosolic compartment of calcium ions sequestered in the endoplasmic reticulum or mitochondria." [GOC:ai] +synonym: "down regulation of release of sequestered calcium ion into cytosol" EXACT [] +synonym: "down-regulation of release of sequestered calcium ion into cytosol" EXACT [] +synonym: "downregulation of release of sequestered calcium ion into cytosol" EXACT [] +synonym: "inhibition of release of sequestered calcium ion into cytosol" NARROW [] +synonym: "negative regulation of calcium ion (Ca2+) mobilization" BROAD [] +synonym: "negative regulation of calcium mobilization" BROAD [] +synonym: "negative regulation of cytoplasmic release of sequestered calcium ion (Ca2+)" BROAD [] +synonym: "negative regulation of cytoplasmic release of stored calcium ion (Ca2+)" BROAD [] +synonym: "negative regulation of cytosolic release of sequestered calcium ion (Ca2+)" EXACT [] +synonym: "negative regulation of cytosolic release of stored calcium ion (Ca2+)" EXACT [] +synonym: "negative regulation of release of sequestered calcium ion (Ca2+)" BROAD [] +synonym: "negative regulation of release of sequestered calcium ion into cytoplasm" BROAD [] +synonym: "negative regulation of release of stored calcium ion (Ca2+)" BROAD [] +synonym: "negative regulation of release of stored calcium ion (Ca2+) into cytoplasm" BROAD [] +synonym: "negative regulation of release of stored calcium ion (Ca2+) into cytosol" EXACT [] +is_a: GO:0051279 ! regulation of release of sequestered calcium ion into cytosol +is_a: GO:0051284 ! positive regulation of sequestering of calcium ion +is_a: GO:1903170 ! negative regulation of calcium ion transmembrane transport +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:0051209 ! release of sequestered calcium ion into cytosol +relationship: negatively_regulates GO:0051209 ! release of sequestered calcium ion into cytosol + +[Term] +id: GO:0051281 +name: positive regulation of release of sequestered calcium ion into cytosol +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the release into the cytosolic compartment of calcium ions sequestered in the endoplasmic reticulum or mitochondria." [GOC:ai] +synonym: "activation of release of sequestered calcium ion into cytosol" NARROW [] +synonym: "positive regulation of calcium ion (Ca2+) mobilization" BROAD [] +synonym: "positive regulation of calcium mobilization" BROAD [] +synonym: "positive regulation of cytoplasmic release of sequestered calcium ion (Ca2+)" BROAD [] +synonym: "positive regulation of cytoplasmic release of stored calcium ion (Ca2+)" BROAD [] +synonym: "positive regulation of cytosolic release of sequestered calcium ion (Ca2+)" EXACT [] +synonym: "positive regulation of cytosolic release of stored calcium ion (Ca2+)" EXACT [] +synonym: "positive regulation of release of sequestered calcium ion (Ca2+)" BROAD [] +synonym: "positive regulation of release of sequestered calcium ion into cytoplasm" BROAD [] +synonym: "positive regulation of release of stored calcium ion (Ca2+)" BROAD [] +synonym: "positive regulation of release of stored calcium ion (Ca2+) into cytoplasm" BROAD [] +synonym: "positive regulation of release of stored calcium ion (Ca2+) into cytosol" EXACT [] +synonym: "stimulation of release of sequestered calcium ion into cytosol" NARROW [] +synonym: "up regulation of release of sequestered calcium ion into cytosol" EXACT [] +synonym: "up-regulation of release of sequestered calcium ion into cytosol" EXACT [] +synonym: "upregulation of release of sequestered calcium ion into cytosol" EXACT [] +is_a: GO:0051279 ! regulation of release of sequestered calcium ion into cytosol +is_a: GO:1904427 ! positive regulation of calcium ion transmembrane transport +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates GO:0051209 ! release of sequestered calcium ion into cytosol +relationship: positively_regulates GO:0051209 ! release of sequestered calcium ion into cytosol + +[Term] +id: GO:0051282 +name: regulation of sequestering of calcium ion +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the binding or confining calcium ions such that they are separated from other components of a biological system." [GOC:ai] +synonym: "regulation of calcium ion (Ca2+) retention" EXACT [] +synonym: "regulation of calcium ion (Ca2+) sequestering" EXACT [] +synonym: "regulation of calcium ion (Ca2+) sequestration" EXACT [] +synonym: "regulation of calcium ion (Ca2+) storage" EXACT [] +synonym: "regulation of retention of calcium ion (Ca2+)" EXACT [] +synonym: "regulation of sequestering of calcium ion (Ca2+)" EXACT [] +synonym: "regulation of sequestration of calcium ion (Ca2+)" EXACT [] +synonym: "regulation of storage of calcium ion (Ca2+)" EXACT [] +is_a: GO:0032879 ! regulation of localization +is_a: GO:0050794 ! regulation of cellular process +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:0051208 ! sequestering of calcium ion +relationship: regulates GO:0051208 ! sequestering of calcium ion + +[Term] +id: GO:0051283 +name: negative regulation of sequestering of calcium ion +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the binding or confining calcium ions such that they are separated from other components of a biological system." [GOC:ai] +synonym: "down regulation of sequestering of calcium ion" EXACT [] +synonym: "down-regulation of sequestering of calcium ion" EXACT [] +synonym: "downregulation of sequestering of calcium ion" EXACT [] +synonym: "inhibition of sequestering of calcium ion" NARROW [] +synonym: "negative regulation of calcium ion (Ca2+) retention" EXACT [] +synonym: "negative regulation of calcium ion (Ca2+) sequestering" EXACT [] +synonym: "negative regulation of calcium ion (Ca2+) sequestration" EXACT [] +synonym: "negative regulation of calcium ion (Ca2+) storage" EXACT [] +synonym: "negative regulation of retention of calcium ion (Ca2+)" EXACT [] +synonym: "negative regulation of sequestering of calcium ion (Ca2+)" EXACT [] +synonym: "negative regulation of sequestration of calcium ion (Ca2+)" EXACT [] +synonym: "negative regulation of storage of calcium ion (Ca2+)" EXACT [] +is_a: GO:0048523 ! negative regulation of cellular process +is_a: GO:0051282 ! regulation of sequestering of calcium ion +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:0051208 ! sequestering of calcium ion +relationship: negatively_regulates GO:0051208 ! sequestering of calcium ion + +[Term] +id: GO:0051284 +name: positive regulation of sequestering of calcium ion +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the binding or confining calcium ions such that they are separated from other components of a biological system." [GOC:ai] +synonym: "activation of sequestering of calcium ion" NARROW [] +synonym: "positive regulation of calcium ion (Ca2+) retention" EXACT [] +synonym: "positive regulation of calcium ion (Ca2+) sequestering" EXACT [] +synonym: "positive regulation of calcium ion (Ca2+) sequestration" EXACT [] +synonym: "positive regulation of calcium ion (Ca2+) storage" EXACT [] +synonym: "positive regulation of retention of calcium ion (Ca2+)" EXACT [] +synonym: "positive regulation of sequestering of calcium ion (Ca2+)" EXACT [] +synonym: "positive regulation of sequestration of calcium ion (Ca2+)" EXACT [] +synonym: "positive regulation of storage of calcium ion (Ca2+)" EXACT [] +synonym: "stimulation of sequestering of calcium ion" NARROW [] +synonym: "up regulation of sequestering of calcium ion" EXACT [] +synonym: "up-regulation of sequestering of calcium ion" EXACT [] +synonym: "upregulation of sequestering of calcium ion" EXACT [] +is_a: GO:0048522 ! positive regulation of cellular process +is_a: GO:0051282 ! regulation of sequestering of calcium ion +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates GO:0051208 ! sequestering of calcium ion +relationship: positively_regulates GO:0051208 ! sequestering of calcium ion + [Term] id: GO:0051301 name: cell division @@ -91537,18 +91618,6 @@ intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0016740 ! transferase activity relationship: regulates GO:0016740 ! transferase activity -[Term] -id: GO:0051340 -name: regulation of ligase activity -namespace: biological_process -def: "Any process that modulates the frequency, rate or extent of ligase activity, the catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6." [GOC:ai] -subset: gocheck_do_not_annotate -synonym: "ligase regulator" EXACT [] -is_a: GO:0050790 ! regulation of catalytic activity -intersection_of: GO:0065007 ! biological regulation -intersection_of: regulates GO:0016874 ! ligase activity -relationship: regulates GO:0016874 ! ligase activity - [Term] id: GO:0051345 name: positive regulation of hydrolase activity @@ -91623,41 +91692,6 @@ intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0016740 ! transferase activity relationship: negatively_regulates GO:0016740 ! transferase activity -[Term] -id: GO:0051351 -name: positive regulation of ligase activity -namespace: biological_process -def: "Any process that activates or increases the frequency, rate or extent of ligase activity, the catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate." [GOC:ai] -subset: gocheck_do_not_annotate -synonym: "activation of ligase activity" NARROW [] -synonym: "ligase activator" EXACT [] -synonym: "stimulation of ligase activity" NARROW [] -synonym: "up regulation of ligase activity" EXACT [] -synonym: "up-regulation of ligase activity" EXACT [] -synonym: "upregulation of ligase activity" EXACT [] -is_a: GO:0043085 ! positive regulation of catalytic activity -is_a: GO:0051340 ! regulation of ligase activity -intersection_of: GO:0065007 ! biological regulation -intersection_of: positively_regulates GO:0016874 ! ligase activity -relationship: positively_regulates GO:0016874 ! ligase activity - -[Term] -id: GO:0051352 -name: negative regulation of ligase activity -namespace: biological_process -def: "Any process that stops or reduces the rate of ligase activity, the catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate." [GOC:ai] -subset: gocheck_do_not_annotate -synonym: "down regulation of ligase activity" EXACT [] -synonym: "down-regulation of ligase activity" EXACT [] -synonym: "downregulation of ligase activity" EXACT [] -synonym: "inhibition of ligase activity" NARROW [] -synonym: "ligase inhibitor" EXACT [] -is_a: GO:0043086 ! negative regulation of catalytic activity -is_a: GO:0051340 ! regulation of ligase activity -intersection_of: GO:0065007 ! biological regulation -intersection_of: negatively_regulates GO:0016874 ! ligase activity -relationship: negatively_regulates GO:0016874 ! ligase activity - [Term] id: GO:0051355 name: proprioception involved in equilibrioception @@ -91765,9 +91799,9 @@ synonym: "programmed cell death of neurons by apoptosis" EXACT [] synonym: "programmed cell death, neuronal cells" EXACT [] synonym: "programmed cell death, neurons" EXACT [] is_a: GO:0006915 ! apoptotic process -is_a: GO:0070997 ! neuron death intersection_of: GO:0006915 ! apoptotic process intersection_of: occurs_in CL:0000540 ! neuron +relationship: occurs_in CL:0000540 ! neuron [Term] id: GO:0051410 @@ -91856,6 +91890,31 @@ intersection_of: GO:0016477 ! cell migration intersection_of: results_in_movement_of CL:0000056 ! myoblast relationship: results_in_movement_of CL:0000056 ! myoblast +[Term] +id: GO:0051457 +name: maintenance of protein location in nucleus +namespace: biological_process +def: "Any process in which a protein is maintained in the nucleus and prevented from moving elsewhere. These include sequestration within the nucleus, protein stabilization to prevent transport elsewhere and the active retrieval of proteins that escape the nucleus." [GOC:ai] +synonym: "maintenance of nuclear protein localization" EXACT [] +synonym: "maintenance of protein localization in nucleus" RELATED [GOC:dph, GOC:tb] +synonym: "maintenance of protein location in cell nucleus" EXACT [] +synonym: "nuclear protein retention" NARROW [] +synonym: "nuclear protein sequestering" NARROW [] +synonym: "nuclear protein sequestration" NARROW [] +synonym: "protein retention in nucleus" NARROW [] +synonym: "protein sequestration in nucleus" NARROW [] +synonym: "protein storage in nucleus" NARROW [] +synonym: "protein-nuclear retention" NARROW [] +synonym: "sequestration of protein in nucleus" NARROW [] +synonym: "storage of protein in nucleus" NARROW [] +is_a: GO:0072595 ! maintenance of protein localization in organelle +intersection_of: GO:0045185 ! maintenance of protein location +intersection_of: occurs_in GO:0005634 ! nucleus +relationship: in_taxon NCBITaxon:2759 {all_only="true"} ! Eukaryota +relationship: occurs_in GO:0005634 ! nucleus +relationship: only_in_taxon NCBITaxon:2759 ! Eukaryota +relationship: part_of GO:0034504 ! protein localization to nucleus + [Term] id: GO:0051458 name: corticotropin secretion @@ -92049,6 +92108,51 @@ intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0051546 ! keratinocyte migration relationship: positively_regulates GO:0051546 ! keratinocyte migration +[Term] +id: GO:0051580 +name: regulation of neurotransmitter uptake +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of a neurotransmitter into a neuron or glial cell." [GOC:ai] +subset: goslim_synapse +synonym: "regulation of neurotransmitter import" EXACT [GOC:dph, GOC:tb] +synonym: "regulation of neurotransmitter reuptake" EXACT [] +is_a: GO:0051588 ! regulation of neurotransmitter transport +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:0001504 ! neurotransmitter uptake +relationship: regulates GO:0001504 ! neurotransmitter uptake + +[Term] +id: GO:0051581 +name: negative regulation of neurotransmitter uptake +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a neurotransmitter into a neuron or glial cell." [GOC:ai] +synonym: "down regulation of neurotransmitter uptake" EXACT [] +synonym: "down-regulation of neurotransmitter uptake" EXACT [] +synonym: "downregulation of neurotransmitter uptake" EXACT [] +synonym: "negative regulation of neurotransmitter import" EXACT [GOC:dph, GOC:tb] +is_a: GO:0051580 ! regulation of neurotransmitter uptake +is_a: GO:0051589 ! negative regulation of neurotransmitter transport +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:0001504 ! neurotransmitter uptake +relationship: negatively_regulates GO:0001504 ! neurotransmitter uptake + +[Term] +id: GO:0051582 +name: positive regulation of neurotransmitter uptake +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the directed movement of a neurotransmitter into a neuron or glial cell." [GOC:ai] +synonym: "activation of neurotransmitter uptake" NARROW [] +synonym: "positive regulation of neurotransmitter import" EXACT [GOC:dph, GOC:tb] +synonym: "stimulation of neurotransmitter uptake" NARROW [] +synonym: "up regulation of neurotransmitter uptake" EXACT [] +synonym: "up-regulation of neurotransmitter uptake" EXACT [] +synonym: "upregulation of neurotransmitter uptake" EXACT [] +is_a: GO:0051580 ! regulation of neurotransmitter uptake +is_a: GO:0051590 ! positive regulation of neurotransmitter transport +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates GO:0001504 ! neurotransmitter uptake +relationship: positively_regulates GO:0001504 ! neurotransmitter uptake + [Term] id: GO:0051588 name: regulation of neurotransmitter transport @@ -92164,6 +92268,64 @@ intersection_of: GO:0006810 ! transport intersection_of: has_primary_input CHEBI:58432 relationship: has_primary_input CHEBI:58432 +[Term] +id: GO:0051615 +name: histamine uptake +namespace: biological_process +def: "The directed movement of histamine into a cell, typically presynaptic neurons or glial cells. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans." [GOC:ai] +synonym: "histamine import" EXACT [GOC:dph, GOC:tb] +is_a: GO:0001504 ! neurotransmitter uptake +is_a: GO:0051608 ! histamine transport +intersection_of: GO:0006810 ! transport +intersection_of: has_primary_input CHEBI:58432 +intersection_of: has_target_end_location GO:0005829 ! cytosol +intersection_of: has_target_start_location GO:0005576 ! extracellular region +relationship: has_target_end_location GO:0005829 ! cytosol +relationship: has_target_start_location GO:0005576 ! extracellular region + +[Term] +id: GO:0051616 +name: regulation of histamine uptake +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of the directed movement of the neurotransmitter histamine into a cell." [GOC:ai] +synonym: "regulation of histamine import" EXACT [GOC:dph, GOC:tb] +is_a: GO:0051580 ! regulation of neurotransmitter uptake +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:0051615 ! histamine uptake +relationship: regulates GO:0051615 ! histamine uptake + +[Term] +id: GO:0051617 +name: negative regulation of histamine uptake +namespace: biological_process +def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of histamine into a cell." [GOC:ai] +synonym: "down regulation of histamine uptake" EXACT [] +synonym: "down-regulation of histamine uptake" EXACT [] +synonym: "downregulation of histamine uptake" EXACT [] +synonym: "negative regulation of histamine import" EXACT [GOC:dph, GOC:tb] +is_a: GO:0051581 ! negative regulation of neurotransmitter uptake +is_a: GO:0051616 ! regulation of histamine uptake +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:0051615 ! histamine uptake +relationship: negatively_regulates GO:0051615 ! histamine uptake + +[Term] +id: GO:0051618 +name: positive regulation of histamine uptake +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of the directed movement of histamine into a cell." [GOC:ai] +synonym: "activation of histamine uptake" NARROW [] +synonym: "positive regulation of histamine import" EXACT [GOC:dph, GOC:tb] +synonym: "stimulation of histamine uptake" NARROW [] +synonym: "up regulation of histamine uptake" EXACT [] +synonym: "up-regulation of histamine uptake" EXACT [] +synonym: "upregulation of histamine uptake" EXACT [] +is_a: GO:0051582 ! positive regulation of neurotransmitter uptake +is_a: GO:0051616 ! regulation of histamine uptake +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates GO:0051615 ! histamine uptake +relationship: positively_regulates GO:0051615 ! histamine uptake + [Term] id: GO:0051620 name: norepinephrine uptake @@ -92457,6 +92619,53 @@ is_a: GO:0051656 ! establishment of organelle localization intersection_of: GO:0051234 ! establishment of localization intersection_of: has_primary_input GO:0031982 ! vesicle +[Term] +id: GO:0051651 +name: maintenance of location in cell +namespace: biological_process +def: "Any process in which a substance or cellular entity, such as a protein complex or organelle, is maintained in a specific location within, or in the membrane of, a cell, and is prevented from moving elsewhere." [GOC:ai] +synonym: "cellular retention" NARROW [] +synonym: "cellular sequestering" NARROW [] +synonym: "cellular storage" NARROW [] +synonym: "intracellular retention" NARROW [] +synonym: "intracellular sequestering" NARROW [] +synonym: "intracellular storage" NARROW [] +synonym: "maintenance of cellular localization" RELATED [GOC:dph, GOC:tb] +synonym: "maintenance of intracellular localization" NARROW [] +synonym: "maintenance of localization in cell" RELATED [GOC:dph, GOC:tb] +synonym: "maintenance of localization within cell" NARROW [] +synonym: "retention within cell" NARROW [] +synonym: "sequestering within cell" NARROW [] +synonym: "storage within cell" NARROW [] +is_a: GO:0009987 ! cellular process +is_a: GO:0051235 ! maintenance of location +intersection_of: GO:0051235 ! maintenance of location +intersection_of: occurs_in CL:0000000 ! cell +relationship: occurs_in CL:0000000 ! cell +relationship: part_of GO:0051641 ! cellular localization + +[Term] +id: GO:0051652 +name: maintenance of chromosome location +namespace: biological_process +def: "Any process in which a chromosome is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb] +synonym: "maintenance of chromosome localization" RELATED [GOC:dph, GOC:tb] +is_a: GO:0050000 ! chromosome localization +is_a: GO:0051657 ! maintenance of organelle location +intersection_of: GO:0051651 ! maintenance of location in cell +intersection_of: has_primary_input GO:0005694 ! chromosome + +[Term] +id: GO:0051655 +name: maintenance of vesicle location +namespace: biological_process +def: "Any process in which a vesicle is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb] +synonym: "maintenance of vesicle localization" RELATED [GOC:dph, GOC:tb] +is_a: GO:0051648 ! vesicle localization +is_a: GO:0051657 ! maintenance of organelle location +intersection_of: GO:0051651 ! maintenance of location in cell +intersection_of: has_primary_input GO:0031982 ! vesicle + [Term] id: GO:0051656 name: establishment of organelle localization @@ -92468,6 +92677,27 @@ is_a: GO:0051640 ! organelle localization intersection_of: GO:0051234 ! establishment of localization intersection_of: has_primary_input GO:0043226 ! organelle +[Term] +id: GO:0051657 +name: maintenance of organelle location +namespace: biological_process +def: "Any process in which an organelle is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb] +synonym: "maintenance of organelle localization" RELATED [GOC:dph, GOC:tb] +is_a: GO:0051651 ! maintenance of location in cell +relationship: part_of GO:0051640 ! organelle localization + +[Term] +id: GO:0051658 +name: maintenance of nucleus location +namespace: biological_process +def: "Any process in which the nucleus is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb] +synonym: "maintenance of cell nucleus location" EXACT [] +synonym: "maintenance of nucleus localization" RELATED [GOC:dph, GOC:tb] +is_a: GO:0051647 ! nucleus localization +is_a: GO:0051657 ! maintenance of organelle location +intersection_of: GO:0051651 ! maintenance of location in cell +intersection_of: has_primary_input GO:0005634 ! nucleus + [Term] id: GO:0051668 name: localization within membrane @@ -92512,6 +92742,19 @@ is_a: GO:0051656 ! establishment of organelle localization intersection_of: GO:0051234 ! establishment of localization intersection_of: has_primary_input GO:0005794 ! Golgi apparatus +[Term] +id: GO:0051684 +name: maintenance of Golgi location +namespace: biological_process +def: "Any process in which the Golgi is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb] +synonym: "maintenance of Golgi apparatus localization" EXACT [] +synonym: "maintenance of Golgi body localization" EXACT [] +synonym: "maintenance of Golgi localization" RELATED [GOC:dph, GOC:tb] +is_a: GO:0051645 ! Golgi localization +is_a: GO:0051657 ! maintenance of organelle location +intersection_of: GO:0051651 ! maintenance of location in cell +intersection_of: has_primary_input GO:0005794 ! Golgi apparatus + [Term] id: GO:0051707 name: response to other organism @@ -93937,29 +94180,6 @@ intersection_of: GO:0048856 ! anatomical structure development intersection_of: results_in_development_of UBERON:0007375 ! roof of mouth relationship: results_in_development_of UBERON:0007375 ! roof of mouth -[Term] -id: GO:0060032 -name: notochord regression -namespace: biological_process -def: "The developmental process in which the stucture of the notochord is destroyed in an embryo." [GOC:dph] -is_a: GO:0060033 ! anatomical structure regression -intersection_of: GO:0060033 ! anatomical structure regression -intersection_of: has_input UBERON:0002328 ! notochord -relationship: has_input UBERON:0002328 ! notochord -relationship: part_of GO:0048570 ! notochord morphogenesis - -[Term] -id: GO:0060033 -name: anatomical structure regression -namespace: biological_process -def: "The developmental process in which an anatomical stucture is destroyed as a part of its normal progression." [GOC:dph] -synonym: "histolysis" RELATED [GOC:mtg_apoptosis] -synonym: "tissue death" RELATED [GOC:mtg_apoptosis] -is_a: GO:0032502 ! developmental process -relationship: in_taxon NCBITaxon:2759 {all_only="true"} ! Eukaryota -relationship: only_in_taxon NCBITaxon:2759 ! Eukaryota -relationship: part_of GO:0009653 ! anatomical structure morphogenesis - [Term] id: GO:0060034 name: notochord cell differentiation @@ -96762,19 +96982,6 @@ relationship: regulates GO:0007018 ! microtubule-based movement created_by: dph creation_date: 2009-05-18T03:07:02Z -[Term] -id: GO:0060641 -name: mammary gland duct regression in males -namespace: biological_process -def: "The process in which the epithelium of the mammary duct is destroyed in males." [GOC:dph, PMID:12558599] -is_a: GO:0060033 ! anatomical structure regression -intersection_of: GO:0060033 ! anatomical structure regression -intersection_of: has_input UBERON:0001765 ! mammary duct -relationship: has_input UBERON:0001765 ! mammary duct -relationship: part_of GO:0060603 ! mammary gland duct morphogenesis -created_by: dph -creation_date: 2009-05-20T04:50:57Z - [Term] id: GO:0060642 name: white fat cell differentiation involved in mammary gland fat development @@ -99198,6 +99405,19 @@ relationship: results_in_development_of UBERON:0004805 ! seminal vesicle epithel created_by: dph creation_date: 2010-04-30T10:19:54Z +[Term] +id: GO:0061109 +name: dense core granule organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a dense core granule. A dense core granule is a secretory organelle found in endocrine cells." [GOC:dph] +synonym: "dense core granule organisation" EXACT [GOC:mah] +is_a: GO:0033363 ! secretory granule organization +intersection_of: GO:0016043 ! cellular component organization +intersection_of: results_in_organization_of GO:0031045 ! dense core granule +relationship: results_in_organization_of GO:0031045 ! dense core granule +created_by: dph +creation_date: 2010-05-01T09:34:37Z + [Term] id: GO:0061113 name: pancreas morphogenesis @@ -100642,8 +100862,8 @@ id: GO:0061336 name: cell morphogenesis involved in Malpighian tubule morphogenesis namespace: biological_process def: "The shape change of an epithelial cell from a columnar to squamous cell morphology that contributes to the shaping of the Malpighian tubule." [GOC:dph, GOC:mtg_kidney_jan10, PMID:19783135] -is_a: GO:0000904 ! cell morphogenesis involved in differentiation -intersection_of: GO:0000904 ! cell morphogenesis involved in differentiation +is_a: GO:0000902 ! cell morphogenesis +intersection_of: GO:0000902 ! cell morphogenesis intersection_of: part_of GO:0007443 ! Malpighian tubule morphogenesis relationship: part_of GO:0007443 ! Malpighian tubule morphogenesis created_by: dph @@ -100930,6 +101150,23 @@ relationship: results_in_acquisition_of_features_of CL:0002088 ! interstitial ce created_by: dph creation_date: 2012-07-20T08:20:50Z +[Term] +id: GO:0061454 +name: release of sequestered calcium ion into cytosol by Golgi +namespace: biological_process +def: "The directed movement of calcium ions (Ca2+) out of the Golgi apparatus into the cytosol." [GOC:dph, GOC:tb] +synonym: "Golgi calcium ion export" BROAD [] +is_a: GO:0051209 ! release of sequestered calcium ion into cytosol +is_a: GO:0061856 ! Golgi calcium ion transmembrane transport +intersection_of: GO:0006810 ! transport +intersection_of: has_primary_input CHEBI:29108 +intersection_of: has_target_end_location GO:0005829 ! cytosol +intersection_of: has_target_start_location GO:0005794 ! Golgi apparatus +intersection_of: results_in_transport_across GO:0016020 ! membrane +relationship: has_target_start_location GO:0005794 ! Golgi apparatus +created_by: dph +creation_date: 2012-07-27T02:29:43Z + [Term] id: GO:0061458 name: reproductive system development @@ -101538,50 +101775,6 @@ property_value: term_tracker_item "https://github.com/geneontology/go-ontology/i created_by: dph creation_date: 2014-05-15T09:12:24Z -[Term] -id: GO:0061650 -name: ubiquitin-like protein conjugating enzyme activity -namespace: molecular_function -def: "Isoenergetic transfer of a ubiquitin-like protein (ULP) from one protein to another via the reaction X-SCP + Y = Y-SCP + X, where both the X-SCP and Y-SCP linkages are thioester bonds between the C-terminal amino acid of SCP and a sulfhydryl side group of a cysteine residue." [GOC:dph] -synonym: "E2" BROAD [] -synonym: "small conjugating protein conjugating enzyme activity" EXACT [GOC:dph] -is_a: GO:0019787 ! ubiquitin-like protein transferase activity -created_by: dph -creation_date: 2014-11-06T13:15:27Z - -[Term] -id: GO:0061651 -name: Atg12 conjugating enzyme activity -namespace: molecular_function -def: "Isoenergetic transfer of Atg12 from one protein to another via the reaction X-Atg12 + Y = Y-Atg12 + X, where both the X-Atg12 and Y-Atg12 linkages are thioester bonds between the C-terminal amino acid of Atg12 and a sulfhydryl side group of a cysteine residue." [GOC:dph] -synonym: "E2" BROAD [GOC:dph] -is_a: GO:0019777 ! Atg12 transferase activity -is_a: GO:0061650 ! ubiquitin-like protein conjugating enzyme activity -created_by: dph -creation_date: 2014-11-06T13:17:36Z - -[Term] -id: GO:0061659 -name: ubiquitin-like protein ligase activity -namespace: molecular_function -def: "Catalysis of the transfer of a ubiquitin-like protein (ULP) to a substrate protein via the reaction X-ULP + S = X + S-ULP, where X is either an E2 or E3 enzyme, the X-ULP linkage is a thioester bond, and the S-ULP linkage is an isopeptide bond between the C-terminal glycine of ULP and the epsilon-amino group of lysine residues in the substrate." [GOC:dph] -synonym: "E3" RELATED [GOC:dph] -synonym: "small conjugating protein ligase activity" EXACT [GOC:dph] -is_a: GO:0019787 ! ubiquitin-like protein transferase activity -created_by: dph -creation_date: 2014-11-06T13:46:23Z - -[Term] -id: GO:0061660 -name: Atg12 ligase activity -namespace: molecular_function -def: "Catalysis of the transfer of Atg12 to a substrate protein via the reaction X-Atg12 + S = X + S-Atg12, where X is either an E2 or E3 enzyme, the X-Atg12 linkage is a thioester bond, and the S-Atg12 linkage is an isopeptide bond between the C-terminal amino acid of Atg12 and the epsilon-amino group of lysine residues in the substrate." [GOC:dph] -synonym: "E3" BROAD [GOC:dph] -is_a: GO:0019777 ! Atg12 transferase activity -is_a: GO:0061659 ! ubiquitin-like protein ligase activity -created_by: dph -creation_date: 2014-11-06T13:50:42Z - [Term] id: GO:0061682 name: seminal vesicle morphogenesis @@ -101639,24 +101832,25 @@ created_by: dph creation_date: 2015-05-06T11:22:38Z [Term] -id: GO:0061736 -name: engulfment of target by autophagosome +id: GO:0061725 +name: cytosolic lipolysis namespace: biological_process -def: "The membrane invagination process by which an autophagosomal membrane surrounds an object that will be degraded by macroautophagy." [GOC:autophagy, GOC:dph, GOC:pad, GOC:PARL] -is_a: GO:0010324 ! membrane invagination -intersection_of: GO:0010324 ! membrane invagination -intersection_of: part_of GO:0000045 ! autophagosome assembly -relationship: part_of GO:0000045 ! autophagosome assembly +def: "The chemical reactions and pathways resulting in the breakdown of lipid droplets and hydrolysis of stored triglycerides occurring through the orchestrated activation of cytosolic lipases." [GOC:autophagy] +is_a: GO:0044242 ! cellular lipid catabolic process +intersection_of: GO:0009056 ! catabolic process +intersection_of: has_primary_input CHEBI:18059 +intersection_of: occurs_in GO:0005829 ! cytosol +relationship: occurs_in GO:0005829 ! cytosol created_by: dph -creation_date: 2015-09-14T14:10:24Z +creation_date: 2015-07-08T13:42:15Z [Term] id: GO:0061792 name: secretory granule maturation namespace: biological_process def: "Steps required to transform an immature secretory vesicle into a mature secretory vesicle. Typically proceeds through homotypic membrane fusion and membrane remodeling." [GOC:bf, GOC:dph, GOC:PARL, PMID:16618809] -is_a: GO:0021700 ! developmental maturation is_a: GO:0033363 ! secretory granule organization +is_a: GO:0071695 ! anatomical structure maturation intersection_of: GO:0021700 ! developmental maturation intersection_of: results_in_maturation_of GO:0030141 ! secretory granule relationship: results_in_maturation_of GO:0030141 ! secretory granule @@ -101850,28 +102044,6 @@ relationship: part_of GO:0150076 ! neuroinflammatory response created_by: dph creation_date: 2017-06-13T13:06:23Z -[Term] -id: GO:0061906 -name: autophagosome localization -namespace: biological_process -def: "Any process in which an autophagosome is transported to, and/or maintained in, a specific location within the cell." [PMID:26763909] -is_a: GO:1990849 ! vacuolar localization -intersection_of: GO:0051179 ! localization -intersection_of: has_primary_input GO:0005776 ! autophagosome -relationship: has_primary_input GO:0005776 ! autophagosome -created_by: dph -creation_date: 2017-06-28T17:27:57Z - -[Term] -id: GO:0061919 -name: process utilizing autophagic mechanism -namespace: biological_process -def: "A cellular process involving delivery of a portion of the cytoplasm to lysosomes or to the plant or fungal vacuole that does not involve direct transport through the endocytic or vacuolar protein sorting (Vps) pathways. This process typically leads to degradation of the cargo; however, it can also be used to deliver resident proteins, such as in the cytoplasm-to-vacuole targeting (Cvt) pathway." [PMID:21997368, PMID:22966490, PMID:28596378] -subset: gocheck_do_not_annotate -is_a: GO:0009987 ! cellular process -created_by: dph -creation_date: 2017-07-13T19:42:14Z - [Term] id: GO:0061938 name: protein localization to somatodendritic compartment @@ -103186,6 +103358,22 @@ synonym: "thyroid stimulating hormone secretion" EXACT [GOC:mah] synonym: "TSH secretion" EXACT [] is_a: GO:0030072 ! peptide hormone secretion +[Term] +id: GO:0070482 +name: response to oxygen levels +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen." [GOC:BHF, GOC:mah] +is_a: GO:0009628 ! response to abiotic stimulus + +[Term] +id: GO:0070483 +name: detection of hypoxia +namespace: biological_process +def: "The series of events in which a stimulus indicating lowered oxygen tension is received by a cell and converted into a molecular signal. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:BHF, GOC:mah] +synonym: "detection of reduced oxygen levels" EXACT [GOC:vk] +is_a: GO:0001666 ! response to hypoxia +is_a: GO:0003032 ! detection of oxygen + [Term] id: GO:0070507 name: regulation of microtubule cytoskeleton organization @@ -103676,21 +103864,6 @@ relationship: results_in_maturation_of UBERON:0001474 ! bone element created_by: mah creation_date: 2009-10-05T04:35:31Z -[Term] -id: GO:0070997 -name: neuron death -namespace: biological_process -def: "The process of cell death in a neuron." [GOC:BHF, GOC:mah] -comment: This term should not be used for direct annotation. The only exception should be when experimental data (e.g., staining with trypan blue or propidium iodide or use of neuron-specific markers) show that neuron death has occurred, but fail to provide details on death modality (accidental versus programmed). When information is provided on the neuron death mechanism, annotations should be made to the appropriate descendant of 'cell death' (such as, but not limited to, GO:0097300 'programmed necrotic cell death' or GO:0006915 'apoptotic process'), and the cell type captured as an annotation extension; or the term GO:0051402 'neuron apoptotic process' may be considered, if appropriate. -synonym: "neuron cell death" EXACT [GOC:mah, GOC:rl] -synonym: "neuronal cell death" EXACT [GOC:mah] -is_a: GO:0008219 ! cell death -intersection_of: GO:0008219 ! cell death -intersection_of: occurs_in CL:0000540 ! neuron -relationship: occurs_in CL:0000540 ! neuron -created_by: mah -creation_date: 2009-11-03T02:37:17Z - [Term] id: GO:0070998 name: sensory perception of gravity @@ -103789,6 +103962,20 @@ intersection_of: has_input CHEBI:28938 created_by: mah creation_date: 2009-12-03T02:39:40Z +[Term] +id: GO:0071277 +name: cellular response to calcium ion +namespace: biological_process +def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus." [GOC:mah] +synonym: "cellular response to Ca2+ ion" EXACT [GOC:mah] +is_a: GO:0051592 ! response to calcium ion +is_a: GO:0070887 ! cellular response to chemical stimulus +intersection_of: GO:0070887 ! cellular response to chemical stimulus +intersection_of: has_input CHEBI:39124 +relationship: has_input CHEBI:39124 +created_by: mah +creation_date: 2009-12-10T03:55:01Z + [Term] id: GO:0071281 name: cellular response to iron ion @@ -104353,9 +104540,9 @@ namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure to attain its fully functional state." [GOC:mah] is_a: GO:0021700 ! developmental maturation intersection_of: GO:0021700 ! developmental maturation -intersection_of: results_in_maturation_of CARO:0000003 ! connected anatomical structure +intersection_of: results_in_maturation_of UBERON:0000061 ! anatomical structure relationship: part_of GO:0048856 ! anatomical structure development -relationship: results_in_maturation_of CARO:0000003 ! connected anatomical structure +relationship: results_in_maturation_of UBERON:0000061 ! anatomical structure created_by: mah creation_date: 2010-03-02T11:43:38Z @@ -104972,47 +105159,6 @@ relationship: has_primary_output CHEBI:16991 created_by: mah creation_date: 2010-09-15T02:14:33Z -[Term] -id: GO:0071900 -name: regulation of protein serine/threonine kinase activity -namespace: biological_process -def: "Any process that modulates the rate, frequency, or extent of protein serine/threonine kinase activity." [GOC:mah] -subset: gocheck_do_not_annotate -is_a: GO:0045859 ! regulation of protein kinase activity -intersection_of: GO:0065007 ! biological regulation -intersection_of: regulates GO:0004674 ! protein serine/threonine kinase activity -relationship: regulates GO:0004674 ! protein serine/threonine kinase activity -created_by: mah -creation_date: 2010-09-15T03:08:35Z - -[Term] -id: GO:0071901 -name: negative regulation of protein serine/threonine kinase activity -namespace: biological_process -def: "Any process that decreases the rate, frequency, or extent of protein serine/threonine kinase activity." [GOC:BHF, GOC:mah] -subset: gocheck_do_not_annotate -is_a: GO:0006469 ! negative regulation of protein kinase activity -is_a: GO:0071900 ! regulation of protein serine/threonine kinase activity -intersection_of: GO:0065007 ! biological regulation -intersection_of: negatively_regulates GO:0004674 ! protein serine/threonine kinase activity -relationship: negatively_regulates GO:0004674 ! protein serine/threonine kinase activity -created_by: mah -creation_date: 2010-09-15T03:09:43Z - -[Term] -id: GO:0071902 -name: positive regulation of protein serine/threonine kinase activity -namespace: biological_process -def: "Any process that increases the rate, frequency, or extent of protein serine/threonine kinase activity." [GOC:mah] -subset: gocheck_do_not_annotate -is_a: GO:0045860 ! positive regulation of protein kinase activity -is_a: GO:0071900 ! regulation of protein serine/threonine kinase activity -intersection_of: GO:0065007 ! biological regulation -intersection_of: positively_regulates GO:0004674 ! protein serine/threonine kinase activity -relationship: positively_regulates GO:0004674 ! protein serine/threonine kinase activity -created_by: mah -creation_date: 2010-09-15T03:09:57Z - [Term] id: GO:0071941 name: nitrogen cycle metabolic process @@ -108075,6 +108221,21 @@ intersection_of: has_target_end_location GO:0043226 ! organelle created_by: mah creation_date: 2011-02-14T01:56:51Z +[Term] +id: GO:0072595 +name: maintenance of protein localization in organelle +namespace: biological_process +def: "Any process in which a protein is maintained in a specific location a specific location on or in an organelle, and is prevented from moving elsewhere. Encompasses establishment of localization in the membrane or lumen of a membrane-bounded organelle." [GOC:mah] +synonym: "maintenance of protein localisation to organelle" EXACT [GOC:mah] +synonym: "maintenance of protein localization to organelle" EXACT [] +is_a: GO:0032507 ! maintenance of protein location in cell +intersection_of: GO:0045185 ! maintenance of protein location +intersection_of: occurs_in GO:0043226 ! organelle +relationship: occurs_in GO:0043226 ! organelle +relationship: part_of GO:0033365 ! protein localization to organelle +created_by: mah +creation_date: 2011-02-14T02:09:13Z + [Term] id: GO:0072657 name: protein localization to membrane @@ -108139,6 +108300,19 @@ intersection_of: has_target_end_location GO:0005773 ! vacuole created_by: mah creation_date: 2011-02-14T02:56:29Z +[Term] +id: GO:0072667 +name: maintenance of protein location in vacuole +namespace: biological_process +def: "Any process in which a protein is maintained in a specific location in a vacuole, and is prevented from moving elsewhere." [GOC:mah] +is_a: GO:0072595 ! maintenance of protein localization in organelle +intersection_of: GO:0045185 ! maintenance of protein location +intersection_of: occurs_in GO:0005773 ! vacuole +relationship: occurs_in GO:0005773 ! vacuole +relationship: part_of GO:0072665 ! protein localization to vacuole +created_by: mah +creation_date: 2011-02-14T02:56:57Z + [Term] id: GO:0072674 name: multinuclear osteoclast differentiation @@ -108727,6 +108901,34 @@ relationship: part_of GO:0003015 ! heart process created_by: bf creation_date: 2012-03-19T01:28:23Z +[Term] +id: GO:0089704 +name: L-glutamate transmembrane export from vacuole +namespace: biological_process +def: "The directed movement of L-glutamate out of the vacuole, across the vacuolar membrane." [PMID:21307582] +is_a: GO:0015813 ! L-glutamate transmembrane transport +is_a: GO:0032974 ! amino acid transmembrane export from vacuole +intersection_of: GO:0006810 ! transport +intersection_of: has_primary_input CHEBI:29985 +intersection_of: has_target_end_location GO:0005829 ! cytosol +intersection_of: has_target_start_location GO:0005775 ! vacuolar lumen +intersection_of: results_in_transport_across GO:0016020 ! membrane + +[Term] +id: GO:0089708 +name: L-histidine transmembrane export from vacuole +namespace: biological_process +def: "The directed movement of L-histidine out of the vacuole, across the vacuolar membrane." [PMID:21307582] +is_a: GO:0032974 ! amino acid transmembrane export from vacuole +is_a: GO:0089709 ! L-histidine transmembrane transport +is_a: GO:1902024 ! L-histidine transport +is_a: GO:1990822 ! basic amino acid transmembrane transport +intersection_of: GO:0015802 ! basic amino acid transport +intersection_of: has_primary_input CHEBI:57595 +intersection_of: has_target_end_location GO:0005829 ! cytosol +intersection_of: has_target_start_location GO:0005775 ! vacuolar lumen +intersection_of: results_in_transport_across GO:0016020 ! membrane + [Term] id: GO:0089709 name: L-histidine transmembrane transport @@ -108738,6 +108940,28 @@ intersection_of: has_primary_input CHEBI:57595 intersection_of: results_in_transport_across GO:0016020 ! membrane relationship: has_primary_input CHEBI:57595 +[Term] +id: GO:0089718 +name: amino acid import across plasma membrane +namespace: biological_process +alt_id: GO:0043092 +alt_id: GO:0044745 +alt_id: GO:1902837 +def: "The directed movement of an amino acid from outside of a cell, across the plasma membrane and into the cytosol." [GOC:krc, PMID:8195186] +synonym: "amino acid import into cell" EXACT [] +synonym: "amino acid transmembrane import" BROAD [] +synonym: "L-amino acid import" BROAD [] +synonym: "L-amino acid uptake" NARROW [] +is_a: GO:0003333 ! amino acid transmembrane transport +is_a: GO:0098739 ! import across plasma membrane +intersection_of: GO:0006810 ! transport +intersection_of: has_primary_input CHEBI:33709 +intersection_of: has_target_end_location GO:0005829 ! cytosol +intersection_of: has_target_start_location GO:0005576 ! extracellular region +intersection_of: results_in_transport_across GO:0005886 ! plasma membrane +created_by: jl +creation_date: 2012-11-14T14:21:41Z + [Term] id: GO:0090009 name: primitive streak formation @@ -109089,6 +109313,22 @@ intersection_of: has_target_end_location GO:0016020 ! membrane created_by: tb creation_date: 2009-12-08T03:18:51Z +[Term] +id: GO:0090160 +name: Golgi to lysosome transport +namespace: biological_process +def: "The directed movement of substances from the Golgi to lysosomes." [GOC:ascb_2009, GOC:dph, GOC:tb] +is_a: GO:0006896 ! Golgi to vacuole transport +is_a: GO:0007041 ! lysosomal transport +is_a: GO:0016482 ! cytosolic transport +intersection_of: GO:0016192 ! vesicle-mediated transport +intersection_of: has_target_end_location GO:0005764 ! lysosome +intersection_of: has_target_start_location GO:0005794 ! Golgi apparatus +intersection_of: occurs_in GO:0005829 ! cytosol +relationship: has_target_end_location GO:0005764 ! lysosome +created_by: tb +creation_date: 2009-12-08T08:35:13Z + [Term] id: GO:0090162 name: establishment of epithelial cell polarity @@ -109145,7 +109385,7 @@ id: GO:0090171 name: chondrocyte morphogenesis namespace: biological_process def: "The process in which the structures of a chondrocyte are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a chondrocyte." [GOC:ascb_2009, GOC:dph, GOC:tb] -is_a: GO:0000904 ! cell morphogenesis involved in differentiation +is_a: GO:0000902 ! cell morphogenesis intersection_of: GO:0009653 ! anatomical structure morphogenesis intersection_of: results_in_maturation_of CL:0000138 ! chondrocyte relationship: part_of GO:0002063 ! chondrocyte development @@ -109657,6 +109897,23 @@ relationship: has_target_end_location GO:0005635 ! nuclear envelope created_by: tb creation_date: 2012-07-30T01:50:41Z +[Term] +id: GO:0090454 +name: glutamate transmembrane import into vacuole +namespace: biological_process +def: "The directed movement of glutamate into the vacuole across the vacuolar membrane." [GOC:tb] +synonym: "vacuolar glutamate import" RELATED [GOC:tb] +is_a: GO:0015800 ! acidic amino acid transport +is_a: GO:0032975 ! amino acid transmembrane import into vacuole +intersection_of: GO:0015800 ! acidic amino acid transport +intersection_of: has_primary_input CHEBI:14321 +intersection_of: has_target_end_location GO:0005775 ! vacuolar lumen +intersection_of: has_target_start_location GO:0005829 ! cytosol +intersection_of: results_in_transport_across GO:0016020 ! membrane +relationship: has_primary_input CHEBI:14321 +created_by: tb +creation_date: 2012-09-24T14:12:46Z + [Term] id: GO:0090461 name: intracellular glutamate homeostasis @@ -109726,6 +109983,40 @@ relationship: results_in_movement_of CL:0008019 ! mesenchymal cell created_by: tb creation_date: 2012-10-17T12:08:17Z +[Term] +id: GO:0090513 +name: L-histidine transmembrane import into vacuole +namespace: biological_process +alt_id: GO:0090457 +def: "The directed movement of L-histidine into the vacuole across the vacuolar membrane." [GOC:al] +synonym: "histidine transmembrane import into vacuole" BROAD [] +synonym: "vacuolar histidine import" BROAD [GOC:tb] +is_a: GO:0034490 ! basic amino acid transmembrane import into vacuole +is_a: GO:0089709 ! L-histidine transmembrane transport +is_a: GO:1902024 ! L-histidine transport +intersection_of: GO:0015802 ! basic amino acid transport +intersection_of: has_primary_input CHEBI:57595 +intersection_of: has_target_end_location GO:0005775 ! vacuolar lumen +intersection_of: has_target_start_location GO:0005829 ! cytosol +intersection_of: results_in_transport_across GO:0016020 ! membrane +created_by: tb +creation_date: 2012-12-14T11:25:52Z + +[Term] +id: GO:0090515 +name: L-glutamate transmembrane import into vacuole +namespace: biological_process +def: "The directed movement of L-glutamate into the vacuole across the vacuolar membrane." [GOC:al] +is_a: GO:0015813 ! L-glutamate transmembrane transport +is_a: GO:0032975 ! amino acid transmembrane import into vacuole +intersection_of: GO:0015800 ! acidic amino acid transport +intersection_of: has_primary_input CHEBI:29985 +intersection_of: has_target_end_location GO:0005775 ! vacuolar lumen +intersection_of: has_target_start_location GO:0005829 ! cytosol +intersection_of: results_in_transport_across GO:0016020 ! membrane +created_by: tb +creation_date: 2012-12-14T11:25:52Z + [Term] id: GO:0090521 name: podocyte cell migration @@ -110478,7 +110769,6 @@ namespace: cellular_component def: "Axon of dentate gyrus granule cell projecting to hippocampal area CA3, characterized by expansions (mossy fiber expansions) giving the fibers a mossy appearance. These unmyelinated axons were first described by Ramon y Cajal." [NIF_Subcellular:nlx_subcell_100312, PMID:17765709] xref: NIF_Subcellular:nlx_subcell_100312 is_a: GO:0044302 ! dentate gyrus mossy fiber -relationship: part_of CL:0001033 ! hippocampal granule cell created_by: pr creation_date: 2012-12-19T16:51:57Z @@ -110645,6 +110935,24 @@ relationship: results_in_morphogenesis_of UBERON:0003846 ! thymus epithelium created_by: pr creation_date: 2013-11-28T10:51:03Z +[Term] +id: GO:0097553 +name: calcium ion transmembrane import into cytosol +namespace: biological_process +alt_id: GO:0060401 +def: "A process in which a calcium ion is transported from one side of a membrane to the other into the cytosol by means of some agent such as a transporter or pore." [GOC:vw] +synonym: "calcium transmembrane import into cytosol" BROAD [] +synonym: "cytosolic calcium ion transport" BROAD [] +is_a: GO:0070588 ! calcium ion transmembrane transport +intersection_of: GO:0006810 ! transport +intersection_of: has_primary_input CHEBI:29108 +intersection_of: has_target_end_location GO:0005829 ! cytosol +intersection_of: results_in_transport_across GO:0016020 ! membrane +relationship: has_target_end_location GO:0005829 ! cytosol +property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/23015" xsd:anyURI +created_by: pr +creation_date: 2014-01-23T11:05:13Z + [Term] id: GO:0097576 name: vacuole fusion @@ -110911,6 +111219,32 @@ property_value: term_tracker_item "https://github.com/geneontology/go-ontology/i created_by: dos creation_date: 2013-11-11T12:59:11Z +[Term] +id: GO:0098544 +name: maintenance of protein complex location +namespace: biological_process +def: "Any process in which a protein complex is maintained in a location and prevented from moving elsewhere. These include sequestration, stabilization to prevent transport elsewhere and the active retrieval of protein complexes that move away." [GOC:dos] +is_a: GO:0031503 ! protein-containing complex localization +is_a: GO:0051235 ! maintenance of location +intersection_of: GO:0051235 ! maintenance of location +intersection_of: has_primary_input GO:0032991 ! protein-containing complex +created_by: dos +creation_date: 2013-11-15T18:20:16Z + +[Term] +id: GO:0098545 +name: maintenance of protein complex location in cytoplasm +namespace: biological_process +def: "Any process in which a protein complex is maintained in a specific location within the cytoplasm and is prevented from moving elsewhere." [GOC:dos] +is_a: GO:0051651 ! maintenance of location in cell +is_a: GO:0098544 ! maintenance of protein complex location +intersection_of: GO:0098544 ! maintenance of protein complex location +intersection_of: has_primary_input GO:0032991 ! protein-containing complex +intersection_of: occurs_in GO:0005737 ! cytoplasm +relationship: occurs_in GO:0005737 ! cytoplasm +created_by: dos +creation_date: 2013-11-15T20:49:15Z + [Term] id: GO:0098588 name: bounding membrane of organelle @@ -111179,6 +111513,104 @@ relationship: regulates GO:0099504 ! synaptic vesicle cycle created_by: dos creation_date: 2017-03-21T16:06:48Z +[Term] +id: GO:0098703 +name: calcium ion import across plasma membrane +namespace: biological_process +alt_id: GO:1990035 +def: "The directed movement of calcium ions from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos] +synonym: "calcium ion import into cell" EXACT [] +synonym: "calcium ion uptake into cell" EXACT [GOC:vw] +is_a: GO:0097553 ! calcium ion transmembrane import into cytosol +is_a: GO:0098739 ! import across plasma membrane +intersection_of: GO:0006810 ! transport +intersection_of: has_primary_input CHEBI:29108 +intersection_of: has_target_end_location GO:0005829 ! cytosol +intersection_of: has_target_start_location GO:0005576 ! extracellular region +intersection_of: results_in_transport_across GO:0005886 ! plasma membrane +created_by: mah +creation_date: 2013-02-07T13:07:59Z + +[Term] +id: GO:0098704 +name: carbohydrate import across plasma membrane +namespace: biological_process +alt_id: GO:0097319 +def: "The directed movement of a carbohydrate from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos] +synonym: "carbohydrate import into cell" EXACT [] +is_a: GO:0034219 ! carbohydrate transmembrane transport +is_a: GO:0098739 ! import across plasma membrane +intersection_of: GO:0006810 ! transport +intersection_of: has_primary_input CHEBI:16646 +intersection_of: has_target_end_location GO:0005829 ! cytosol +intersection_of: has_target_start_location GO:0005576 ! extracellular region +intersection_of: results_in_transport_across GO:0005886 ! plasma membrane +created_by: pr +creation_date: 2012-05-31T02:45:02Z + +[Term] +id: GO:0098708 +name: glucose import across plasma membrane +namespace: biological_process +alt_id: GO:0061490 +alt_id: GO:1990821 +def: "The directed movement of glucose from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos] +synonym: "glucose import into cell" EXACT [] +synonym: "high affinity glucose import" NARROW [] +is_a: GO:0098739 ! import across plasma membrane +is_a: GO:1904659 ! glucose transmembrane transport +intersection_of: GO:0006810 ! transport +intersection_of: has_primary_input CHEBI:17234 +intersection_of: has_target_end_location GO:0005829 ! cytosol +intersection_of: has_target_start_location GO:0005576 ! extracellular region +intersection_of: results_in_transport_across GO:0005886 ! plasma membrane +created_by: al +creation_date: 2012-12-06T14:54:07Z + +[Term] +id: GO:0098711 +name: iron ion import across plasma membrane +namespace: biological_process +alt_id: GO:0097459 +alt_id: GO:0097460 +alt_id: GO:0098707 +def: "The directed movement of iron ions from outside of a cell, across the plasma membrane and into the cytosol." [GOC:mah, PMID:8321236] +synonym: "ferrous ion import into cell" RELATED [GOC:mah] +synonym: "ferrous iron import across plasma membrane" RELATED [] +synonym: "ferrous iron import into cell" RELATED [] +synonym: "iron import into cell" RELATED [GOC:mah] +synonym: "iron ion import into cell" EXACT [] +is_a: GO:0033212 ! iron import into cell +is_a: GO:0034755 ! iron ion transmembrane transport +is_a: GO:0098739 ! import across plasma membrane +intersection_of: GO:0006810 ! transport +intersection_of: has_primary_input CHEBI:24875 +intersection_of: has_target_end_location GO:0005829 ! cytosol +intersection_of: has_target_start_location GO:0005576 ! extracellular region +intersection_of: results_in_transport_across GO:0005886 ! plasma membrane +created_by: pr +creation_date: 2012-12-20T08:29:00Z + +[Term] +id: GO:0098712 +name: L-glutamate import across plasma membrane +namespace: biological_process +alt_id: GO:1903802 +alt_id: GO:1990123 +def: "The directed movement of L-glutamate from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos] +synonym: "L-glutamate import into cell" EXACT [] +synonym: "L-glutamate(1-) import across plasma membrane" BROAD [] +synonym: "L-glutamate(1-) import into cell" EXACT [] +is_a: GO:0015813 ! L-glutamate transmembrane transport +is_a: GO:0089718 ! amino acid import across plasma membrane +intersection_of: GO:0006810 ! transport +intersection_of: has_primary_input CHEBI:29985 +intersection_of: has_target_end_location GO:0005829 ! cytosol +intersection_of: has_target_start_location GO:0005576 ! extracellular region +intersection_of: results_in_transport_across GO:0005886 ! plasma membrane +created_by: mah +creation_date: 2013-06-12T12:32:47Z + [Term] id: GO:0098722 name: asymmetric stem cell division @@ -111228,6 +111660,21 @@ intersection_of: acts_on_population_of CL:0008011 ! skeletal muscle satellite st intersection_of: part_of GO:0043403 ! skeletal muscle tissue regeneration relationship: acts_on_population_of CL:0008011 ! skeletal muscle satellite stem cell +[Term] +id: GO:0098739 +name: import across plasma membrane +namespace: biological_process +def: "The directed movement of some substance from outside of a cell, across the plasma membrane and into the cytosol." [GOC:dos] +synonym: "uptake" BROAD [] +is_a: GO:0055085 ! transmembrane transport +intersection_of: GO:0006810 ! transport +intersection_of: has_target_end_location GO:0005829 ! cytosol +intersection_of: has_target_start_location GO:0005576 ! extracellular region +intersection_of: results_in_transport_across GO:0005886 ! plasma membrane +relationship: has_target_end_location GO:0005829 ! cytosol +relationship: has_target_start_location GO:0005576 ! extracellular region +relationship: results_in_transport_across GO:0005886 ! plasma membrane + [Term] id: GO:0098749 name: cerebellar neuron development @@ -111939,6 +112386,17 @@ is_a: GO:0008066 ! glutamate receptor activity intersection_of: GO:0004930 ! G protein-coupled receptor activity intersection_of: has_input CHEBI:14321 +[Term] +id: GO:0098992 +name: neuronal dense core vesicle +namespace: cellular_component +def: "A dense core vesicle (granule) that is part of a neuron. These vesicles typically contain neuropeptides. They can be found in all parts of neurons, including the soma, dendrites, axonal swellings (varicosities) and synaptic terminals." [GOC:dos, ISBN:978-0-07-181001-2, Wikipedia:Neuropeptide&oldid=713905176] +subset: goslim_synapse +is_a: GO:0031045 ! dense core granule +intersection_of: GO:0031045 ! dense core granule +intersection_of: part_of CL:0000540 ! neuron +relationship: part_of CL:0000540 ! neuron + [Term] id: GO:0099003 name: vesicle-mediated transport in synapse @@ -111952,6 +112410,28 @@ relationship: in_taxon NCBITaxon:33208 {all_only="true"} ! Metazoa relationship: occurs_in GO:0045202 ! synapse relationship: only_in_taxon NCBITaxon:33208 ! Metazoa +[Term] +id: GO:0099012 +name: neuronal dense core vesicle membrane +namespace: cellular_component +def: "The lipid bilayer surrounding a neuronal dense core vesicle." [GOC:dos] +subset: goslim_synapse +is_a: GO:0032127 ! dense core granule membrane +intersection_of: GO:0016020 ! membrane +intersection_of: bounding_layer_of GO:0098992 ! neuronal dense core vesicle +relationship: bounding_layer_of GO:0098992 ! neuronal dense core vesicle +relationship: part_of GO:0098992 ! neuronal dense core vesicle + +[Term] +id: GO:0099014 +name: neuronal dense core vesicle organization +namespace: biological_process +def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuronal dense core vesicle." [GOC:dos] +is_a: GO:0061109 ! dense core granule organization +intersection_of: GO:0016043 ! cellular component organization +intersection_of: results_in_organization_of GO:0098992 ! neuronal dense core vesicle +relationship: results_in_organization_of GO:0098992 ! neuronal dense core vesicle + [Term] id: GO:0099054 name: presynapse assembly @@ -112182,11 +112662,12 @@ creation_date: 2017-07-05T16:40:45Z [Term] id: GO:0099157 -name: trans-synaptic signalling via exosome +name: trans-synaptic signaling via exosome namespace: biological_process def: "Transynaptic signaling in which the ligand is carried across the synapse by an exosome." [GOC:dos, PMID:19837038] subset: goslim_synapse synonym: "exosome mediated transynaptic signalling" EXACT [] +synonym: "trans-synaptic signalling via exosome" EXACT [] is_a: GO:0099156 ! cell-cell signaling via exosome is_a: GO:0099537 ! trans-synaptic signaling intersection_of: GO:0099537 ! trans-synaptic signaling @@ -112463,6 +112944,56 @@ intersection_of: GO:0046907 ! intracellular transport intersection_of: has_primary_input GO:0031982 ! vesicle intersection_of: results_in_transport_along GO:0099513 ! polymeric cytoskeletal fiber +[Term] +id: GO:0099519 +name: dense core granule cytoskeletal transport +namespace: biological_process +def: "The directed movement of dense core granules along cytoskeletal fibers, such as microtubules or actin filaments." [GOC:kmv, PMID:23358451] +synonym: "dense core vesicle cytoskeletal trafficking" EXACT [] +is_a: GO:0099518 ! vesicle cytoskeletal trafficking +is_a: GO:1901950 ! dense core granule transport +intersection_of: GO:0046907 ! intracellular transport +intersection_of: has_primary_input GO:0031045 ! dense core granule +intersection_of: occurs_in GO:0030424 ! axon +intersection_of: results_in_transport_along GO:0099513 ! polymeric cytoskeletal fiber +relationship: occurs_in GO:0030424 ! axon + +[Term] +id: GO:0099522 +name: cytosolic region +namespace: cellular_component +def: "Any (proper) part of the cytosol of a single cell of sufficient size to still be considered cytosol." [GOC:dos] +subset: gocheck_do_not_annotate +synonym: "region of cytosol" EXACT [] +is_a: GO:0005829 ! cytosol +intersection_of: GO:0005829 ! cytosol +intersection_of: part_of GO:0005829 ! cytosol +relationship: part_of GO:0005829 ! cytosol + +[Term] +id: GO:0099523 +name: presynaptic cytosol +namespace: cellular_component +def: "The region of the cytosol consisting of all cytosol that is part of the presynapse." [GOC:dos] +subset: goslim_synapse +is_a: GO:0099522 ! cytosolic region +intersection_of: GO:0005829 ! cytosol +intersection_of: part_of GO:0005829 ! cytosol +intersection_of: part_of GO:0098793 ! presynapse +relationship: part_of GO:0098793 ! presynapse + +[Term] +id: GO:0099524 +name: postsynaptic cytosol +namespace: cellular_component +def: "The region of the cytosol consisting of all cytosol that is part of the postsynapse." [GOC:dos] +subset: goslim_synapse +is_a: GO:0099522 ! cytosolic region +intersection_of: GO:0005829 ! cytosol +intersection_of: part_of GO:0005829 ! cytosol +intersection_of: part_of GO:0098794 ! postsynapse +relationship: part_of GO:0098794 ! postsynapse + [Term] id: GO:0099528 name: G protein-coupled neurotransmitter receptor activity @@ -112681,9 +113212,9 @@ name: chemical synaptic transmission, postsynaptic namespace: biological_process def: "The part of synaptic transmission occurring in the post-synapse: a signal transduction pathway consisting of neurotransmitter receptor activation and its effects on postsynaptic membrane potential and the ionic composition of the postsynaptic cytosol." [GOC:dos] subset: goslim_synapse -synonym: "postsynaptic process involved in chemical synaptic transmission" RELATED syngo_official_label [] +synonym: "postsynaptic process involved in chemical synaptic transmission" EXACT syngo_official_label [] +is_a: GO:0007166 ! cell surface receptor signaling pathway is_a: GO:0050877 ! nervous system process -is_a: GO:1905114 ! cell surface receptor signaling pathway involved in cell-cell signaling intersection_of: GO:0007166 ! cell surface receptor signaling pathway intersection_of: occurs_in GO:0098794 ! postsynapse intersection_of: part_of GO:0007268 ! chemical synaptic transmission @@ -112808,6 +113339,40 @@ is_a: GO:0099530 ! G protein-coupled receptor activity involved in regulation of intersection_of: GO:0099528 ! G protein-coupled neurotransmitter receptor activity intersection_of: part_of GO:0060078 ! regulation of postsynaptic membrane potential +[Term] +id: GO:0099585 +name: release of sequestered calcium ion into presynaptic cytosol +namespace: biological_process +def: "The process in which calcium ions sequestered in the endoplasmic reticulum, Golgi apparatus or mitochondria are released into the presynaptic cytosol." [GOC:dos] +subset: goslim_synapse +is_a: GO:0051209 ! release of sequestered calcium ion into cytosol +is_a: GO:0051649 ! establishment of localization in cell +intersection_of: GO:0006810 ! transport +intersection_of: has_primary_input CHEBI:29108 +intersection_of: has_target_end_location GO:0099523 ! presynaptic cytosol +intersection_of: has_target_start_location GO:0043231 ! intracellular membrane-bounded organelle +intersection_of: results_in_transport_across GO:0031090 ! organelle membrane +relationship: has_target_end_location GO:0099523 ! presynaptic cytosol +relationship: occurs_in GO:0098793 ! presynapse +relationship: results_in_transport_across GO:0031090 ! organelle membrane + +[Term] +id: GO:0099586 +name: release of sequestered calcium ion into postsynaptic cytosol +namespace: biological_process +def: "The process in which calcium ions sequestered in the endoplasmic reticulum, Golgi apparatus or mitochondria are released into the postsynaptic cytosol." [GOC:dos] +subset: goslim_synapse +is_a: GO:0051209 ! release of sequestered calcium ion into cytosol +is_a: GO:0051649 ! establishment of localization in cell +intersection_of: GO:0006810 ! transport +intersection_of: has_primary_input CHEBI:29108 +intersection_of: has_target_end_location GO:0099524 ! postsynaptic cytosol +intersection_of: has_target_start_location GO:0043231 ! intracellular membrane-bounded organelle +intersection_of: results_in_transport_across GO:0031090 ! organelle membrane +relationship: has_target_end_location GO:0099524 ! postsynaptic cytosol +relationship: occurs_in GO:0098794 ! postsynapse +relationship: results_in_transport_across GO:0031090 ! organelle membrane + [Term] id: GO:0099589 name: serotonin receptor activity @@ -113616,6 +114181,7 @@ def: "A part of a cellular organism that is either an immaterial entity or a mat subset: goslim_pir is_a: CARO:0000000 ! anatomical entity is_a: GO:0005575 ! cellular_component +is_a: UBERON:0000061 ! anatomical structure created_by: kmv creation_date: 2019-08-12T18:01:37Z @@ -114289,6 +114855,23 @@ property_value: term_tracker_item "https://github.com/geneontology/go-ontology/i created_by: pg creation_date: 2017-10-23T11:53:42Z +[Term] +id: GO:0140115 +name: export across plasma membrane +namespace: biological_process +def: "The directed movement of some substance from inside of a cell, across the plasma membrane and into the extracellular region." [GOC:pg] +synonym: "efflux" BROAD [] +is_a: GO:0055085 ! transmembrane transport +is_a: GO:0140352 ! export from cell +intersection_of: GO:0006810 ! transport +intersection_of: has_target_end_location GO:0005576 ! extracellular region +intersection_of: has_target_start_location GO:0005829 ! cytosol +intersection_of: results_in_transport_across GO:0005886 ! plasma membrane +relationship: has_target_start_location GO:0005829 ! cytosol +relationship: results_in_transport_across GO:0005886 ! plasma membrane +created_by: pg +creation_date: 2017-10-24T14:38:16Z + [Term] id: GO:0140131 name: positive regulation of lymphocyte chemotaxis @@ -114303,6 +114886,39 @@ relationship: positively_regulates GO:0048247 ! lymphocyte chemotaxis created_by: pg creation_date: 2017-11-02T10:26:40Z +[Term] +id: GO:0140146 +name: calcium ion import into vacuole +namespace: biological_process +def: "The directed movement of calcium cations into the vacuole across the vacuolar membrane." [GOC:vw, PMID:8628289] +is_a: GO:0034486 ! vacuolar transmembrane transport +is_a: GO:0070588 ! calcium ion transmembrane transport +intersection_of: GO:0006810 ! transport +intersection_of: has_primary_input CHEBI:29108 +intersection_of: has_target_end_location GO:0005775 ! vacuolar lumen +intersection_of: has_target_start_location GO:0005829 ! cytosol +intersection_of: results_in_transport_across GO:0005774 ! vacuolar membrane +relationship: has_target_end_location GO:0005775 ! vacuolar lumen +relationship: has_target_start_location GO:0005829 ! cytosol +relationship: results_in_transport_across GO:0005774 ! vacuolar membrane +created_by: pg +creation_date: 2017-12-13T15:15:29Z + +[Term] +id: GO:0140157 +name: ammonium import across plasma membrane +namespace: biological_process +def: "The directed movement of an ammonium ion from outside of a cell, across the plasma membrane and into the cytosol." [GOC:vw, PMID:16999738] +is_a: GO:0072488 ! ammonium transmembrane transport +is_a: GO:0098739 ! import across plasma membrane +intersection_of: GO:0006810 ! transport +intersection_of: has_primary_input CHEBI:28938 +intersection_of: has_target_end_location GO:0005829 ! cytosol +intersection_of: has_target_start_location GO:0005576 ! extracellular region +intersection_of: results_in_transport_across GO:0005886 ! plasma membrane +created_by: pg +creation_date: 2018-01-26T12:39:56Z + [Term] id: GO:0140227 name: serotonin-gated cation-selective signaling pathway @@ -114603,6 +115219,21 @@ property_value: term_tracker_item "https://github.com/geneontology/go-ontology/i created_by: pg creation_date: 2018-08-13T18:38:18Z +[Term] +id: GO:0140271 +name: hexose import across plasma membrane +namespace: biological_process +def: "The directed movement of hexose from outside of a cell, across the plasma membrane and into the cytosol." [PMID:10735857] +is_a: GO:0008645 ! hexose transmembrane transport +is_a: GO:0098739 ! import across plasma membrane +intersection_of: GO:0006810 ! transport +intersection_of: has_primary_input CHEBI:18133 +intersection_of: has_target_end_location GO:0005829 ! cytosol +intersection_of: has_target_start_location GO:0005576 ! extracellular region +intersection_of: results_in_transport_across GO:0005886 ! plasma membrane +created_by: pg +creation_date: 2018-10-01T08:49:49Z + [Term] id: GO:0140297 name: DNA-binding transcription factor binding @@ -114760,31 +115391,6 @@ property_value: term_tracker_item "https://github.com/geneontology/go-ontology/i created_by: pg creation_date: 2021-05-25T12:48:12Z -[Term] -id: GO:0140657 -name: ATP-dependent activity -namespace: molecular_function -def: "A molecular function characterized by the coupling of ATP hydrolysis to other steps of a reaction mechanism to make the reaction energetically favorable, for example to catalyze a reaction or drive transport against a concentration gradient." [PMID:24878343, PMID:25750732, PMID:32933017, PMID:33818025, PMID:33873056, PMID:33988324] -comment: Note that this term represents a grouping class that includes all proteins that use ATP hydrolysis to drive a reaction; it is not meant to capture the ATP hydrolysis reaction itself. To annotate ATP hydrolysis, please use 'ATP hydrolysis activity ; GO:0016887'. -subset: gocheck_do_not_annotate -subset: goslim_chembl -subset: goslim_drosophila -subset: goslim_generic -subset: goslim_yeast -subset: prokaryote_subset -synonym: "ATP hydrolysis-dependent activity" EXACT [] -synonym: "ATPase activity" EXACT [] -synonym: "ATPase activity, coupled" EXACT [] -synonym: "ATPase-dependent activity" EXACT [] -is_a: GO:0003674 ! molecular_function -intersection_of: GO:0003674 ! molecular_function -intersection_of: has_part GO:0016887 ! ATP hydrolysis activity -relationship: has_part GO:0016887 ! ATP hydrolysis activity -property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/21612" xsd:anyURI -property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/22371" xsd:anyURI -created_by: pg -creation_date: 2021-06-15T07:35:06Z - [Term] id: GO:0140667 name: regulation of oxytocin production @@ -114856,6 +115462,22 @@ property_value: term_tracker_item "https://github.com/geneontology/go-ontology/i created_by: pg creation_date: 2021-11-24T17:55:51Z +[Term] +id: GO:0140820 +name: cytosol to Golgi apparatus transport +namespace: biological_process +def: "The directed movement of substances from the cytosol into the Golgi apparatus of a cell." [PMID:28373556] +is_a: GO:0055085 ! transmembrane transport +intersection_of: GO:0055085 ! transmembrane transport +intersection_of: has_target_end_location GO:0005794 ! Golgi apparatus +intersection_of: has_target_start_location GO:0005829 ! cytosol +intersection_of: results_in_transport_across GO:0016020 ! membrane +relationship: has_target_end_location GO:0005794 ! Golgi apparatus +relationship: has_target_start_location GO:0005829 ! cytosol +property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/21524" xsd:anyURI +created_by: pg +creation_date: 2022-05-16T06:59:22Z + [Term] id: GO:0140962 name: multicellular organismal-level chemical homeostasis @@ -115016,7 +115638,7 @@ creation_date: 2018-07-26T12:38:08Z id: GO:0150098 name: glial cell-neuron signaling namespace: biological_process -def: "Cell-cell signaling that mediates the transfer of information from a glial cell to a neuron. This signaling has been shown to be mediated by various molecules, depending on which glial cells release them, and in which tissues the signalling occurs, e.g. microglial cell-derived nerve growth factor (NGF) in the retina, or microglial cell-derived superoxide ions in the cerebellum." [GOC:aruk, GOC:bc, PMID:14980203, PMID:16144764, PMID:16547515, PMID:18685038, PMID:27788368, PMID:9459440] +def: "Cell-cell signaling that mediates the transfer of information from a glial cell to a neuron. This signaling has been shown to be mediated by various molecules, depending on which glial cells release them, and in which tissues the signaling occurs, e.g. microglial cell-derived nerve growth factor (NGF) in the retina, or microglial cell-derived superoxide ions in the cerebellum." [GOC:aruk, GOC:bc, PMID:14980203, PMID:16144764, PMID:16547515, PMID:18685038, PMID:27788368, PMID:9459440] synonym: "glia-neuron signaling" EXACT [] synonym: "glia-neuron signalling" EXACT [] synonym: "glia-neurone signaling" EXACT [] @@ -115037,7 +115659,7 @@ creation_date: 2018-12-17T12:28:09Z id: GO:0150099 name: neuron-glial cell signaling namespace: biological_process -def: "Cell-cell signaling that mediates the transfer of information from a neuron to a glial cell. This signalling has been shown to be mediated by various molecules released by different types of neurons, e.g. glutamate, gamma-amino butyric acid (GABA), noradrenaline, acetylcholine, dopamine and adenosine." [GOC:aruk, GOC:bc, PMID:10195197, PMID:10196584, PMID:10377338, PMID:10493741, PMID:11356870, PMID:11399439, PMID:15252819, PMID:27788368] +def: "Cell-cell signaling that mediates the transfer of information from a neuron to a glial cell. This signaling has been shown to be mediated by various molecules released by different types of neurons, e.g. glutamate, gamma-amino butyric acid (GABA), noradrenaline, acetylcholine, dopamine and adenosine." [GOC:aruk, GOC:bc, PMID:10195197, PMID:10196584, PMID:10377338, PMID:10493741, PMID:11356870, PMID:11399439, PMID:15252819, PMID:27788368] synonym: "neuron-glia signaling" EXACT [] synonym: "neuron-glia signalling" EXACT [] synonym: "neuron-glial cell signalling" EXACT [] @@ -116638,6 +117260,53 @@ relationship: positively_regulates GO:1900205 ! apoptotic process involved in me created_by: yaf creation_date: 2012-03-22T10:54:09Z +[Term] +id: GO:1900247 +name: regulation of cytoplasmic translational elongation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cytoplasmic translational elongation." [GOC:TermGenie] +is_a: GO:0006448 ! regulation of translational elongation +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:0002182 ! cytoplasmic translational elongation +relationship: regulates GO:0002182 ! cytoplasmic translational elongation +created_by: vw +creation_date: 2012-04-03T05:07:02Z + +[Term] +id: GO:1900248 +name: negative regulation of cytoplasmic translational elongation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cytoplasmic translational elongation." [GOC:TermGenie] +synonym: "down regulation of cytoplasmic translational elongation" EXACT [GOC:TermGenie] +synonym: "down-regulation of cytoplasmic translational elongation" EXACT [GOC:TermGenie] +synonym: "downregulation of cytoplasmic translational elongation" EXACT [GOC:TermGenie] +synonym: "inhibition of cytoplasmic translational elongation" NARROW [GOC:TermGenie] +is_a: GO:0045900 ! negative regulation of translational elongation +is_a: GO:1900247 ! regulation of cytoplasmic translational elongation +is_a: GO:2000766 ! negative regulation of cytoplasmic translation +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:0002182 ! cytoplasmic translational elongation +relationship: negatively_regulates GO:0002182 ! cytoplasmic translational elongation +created_by: vw +creation_date: 2012-04-03T05:07:14Z + +[Term] +id: GO:1900249 +name: positive regulation of cytoplasmic translational elongation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cytoplasmic translational elongation." [GOC:TermGenie] +synonym: "activation of cytoplasmic translational elongation" NARROW [GOC:TermGenie] +synonym: "up regulation of cytoplasmic translational elongation" EXACT [GOC:TermGenie] +synonym: "up-regulation of cytoplasmic translational elongation" EXACT [GOC:TermGenie] +synonym: "upregulation of cytoplasmic translational elongation" EXACT [GOC:TermGenie] +is_a: GO:0045901 ! positive regulation of translational elongation +is_a: GO:1900247 ! regulation of cytoplasmic translational elongation +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates GO:0002182 ! cytoplasmic translational elongation +relationship: positively_regulates GO:0002182 ! cytoplasmic translational elongation +created_by: vw +creation_date: 2012-04-03T05:07:24Z + [Term] id: GO:1900366 name: negative regulation of defense response to insect @@ -116867,6 +117536,57 @@ relationship: positively_regulates GO:0007215 ! glutamate receptor signaling pat created_by: rl creation_date: 2012-04-27T03:46:03Z +[Term] +id: GO:1900923 +name: regulation of glycine import across plasma membrane +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of glycine import into a cell." [GOC:TermGenie] +synonym: "regulation of glycine import" BROAD [] +is_a: GO:0010958 ! regulation of amino acid import across plasma membrane +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:1903804 ! glycine import across plasma membrane +relationship: regulates GO:1903804 ! glycine import across plasma membrane +created_by: al +creation_date: 2012-06-13T07:40:11Z + +[Term] +id: GO:1900924 +name: negative regulation of glycine import across plasma membrane +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of glycine import into a cell." [GOC:TermGenie] +synonym: "down regulation of glycine import" EXACT [GOC:TermGenie] +synonym: "down-regulation of glycine import" EXACT [GOC:TermGenie] +synonym: "downregulation of glycine import" EXACT [GOC:TermGenie] +synonym: "inhibition of glycine import" NARROW [GOC:TermGenie] +synonym: "negative regulation of glycine import" BROAD [] +is_a: GO:0034763 ! negative regulation of transmembrane transport +is_a: GO:0051956 ! negative regulation of amino acid transport +is_a: GO:1900923 ! regulation of glycine import across plasma membrane +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:1903804 ! glycine import across plasma membrane +relationship: negatively_regulates GO:1903804 ! glycine import across plasma membrane +created_by: al +creation_date: 2012-06-13T07:40:32Z + +[Term] +id: GO:1900925 +name: positive regulation of glycine import across plasma membrane +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of glycine import." [GOC:TermGenie] +synonym: "activation of glycine import" NARROW [GOC:TermGenie] +synonym: "positive regulation of glycine import" BROAD [] +synonym: "up regulation of glycine import" EXACT [GOC:TermGenie] +synonym: "up-regulation of glycine import" EXACT [GOC:TermGenie] +synonym: "upregulation of glycine import" EXACT [GOC:TermGenie] +is_a: GO:0034764 ! positive regulation of transmembrane transport +is_a: GO:0051957 ! positive regulation of amino acid transport +is_a: GO:1900923 ! regulation of glycine import across plasma membrane +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates GO:1903804 ! glycine import across plasma membrane +relationship: positively_regulates GO:1903804 ! glycine import across plasma membrane +created_by: al +creation_date: 2012-06-13T07:40:40Z + [Term] id: GO:1901019 name: regulation of calcium ion transmembrane transporter activity @@ -117219,6 +117939,31 @@ relationship: positively_regulates GO:0001677 ! formation of translation initiat created_by: ss creation_date: 2012-07-25T02:27:29Z +[Term] +id: GO:1901197 +name: positive regulation of calcium-mediated signaling involved in cellular response to calcium ion +namespace: biological_process +def: "Any positive regulation of calcium-mediated signaling that is involved in cellular response to calcium ion." [GOC:TermGenie] +synonym: "activation of calcium-mediated signaling involved in cellular response to Ca2+ ion" NARROW [GOC:TermGenie] +synonym: "activation of calcium-mediated signaling involved in cellular response to calcium ion" NARROW [GOC:TermGenie] +synonym: "positive regulation of calcium-mediated signaling involved in cellular response to Ca2+ ion" EXACT [GOC:TermGenie] +synonym: "positive regulation of calcium-mediated signalling involved in cellular response to Ca2+ ion" EXACT [GOC:TermGenie] +synonym: "positive regulation of calcium-mediated signalling involved in cellular response to calcium ion" EXACT [GOC:TermGenie] +synonym: "stimulation of calcium-mediated signaling involved in cellular response to Ca2+ ion" NARROW [GOC:TermGenie] +synonym: "stimulation of calcium-mediated signaling involved in cellular response to calcium ion" NARROW [GOC:TermGenie] +synonym: "up regulation of calcium-mediated signaling involved in cellular response to Ca2+ ion" EXACT [GOC:TermGenie] +synonym: "up regulation of calcium-mediated signaling involved in cellular response to calcium ion" EXACT [GOC:TermGenie] +synonym: "up-regulation of calcium-mediated signaling involved in cellular response to Ca2+ ion" EXACT [GOC:TermGenie] +synonym: "up-regulation of calcium-mediated signaling involved in response to calcium ion" EXACT [GOC:TermGenie] +synonym: "upregulation of calcium-mediated signaling involved in cellular response to Ca2+ ion" EXACT [GOC:TermGenie] +synonym: "upregulation of calcium-mediated signaling involved in cellular response to calcium ion" EXACT [GOC:TermGenie] +is_a: GO:0050850 ! positive regulation of calcium-mediated signaling +intersection_of: GO:0050850 ! positive regulation of calcium-mediated signaling +intersection_of: part_of GO:0071277 ! cellular response to calcium ion +relationship: part_of GO:0071277 ! cellular response to calcium ion +created_by: al +creation_date: 2012-07-27T10:57:56Z + [Term] id: GO:1901201 name: regulation of extracellular matrix assembly @@ -117324,76 +118069,6 @@ relationship: positively_regulates GO:0003207 ! cardiac chamber formation created_by: rl creation_date: 2012-07-31T07:19:05Z -[Term] -id: GO:1901214 -name: regulation of neuron death -namespace: biological_process -def: "Any process that modulates the frequency, rate or extent of neuron death." [GOC:rph, GOC:TermGenie] -synonym: "regulation of neuron cell death" EXACT [GOC:TermGenie] -synonym: "regulation of neuronal cell death" EXACT [GOC:TermGenie] -is_a: GO:0050794 ! regulation of cellular process -intersection_of: GO:0065007 ! biological regulation -intersection_of: regulates GO:0070997 ! neuron death -relationship: in_taxon NCBITaxon:33208 {all_only="true"} ! Metazoa -relationship: only_in_taxon NCBITaxon:33208 ! Metazoa -relationship: regulates GO:0070997 ! neuron death -created_by: rph -creation_date: 2012-08-02T09:57:41Z - -[Term] -id: GO:1901215 -name: negative regulation of neuron death -namespace: biological_process -def: "Any process that stops, prevents or reduces the frequency, rate or extent of neuron death." [GOC:rph, GOC:TermGenie] -synonym: "down regulation of neuron cell death" EXACT [GOC:TermGenie] -synonym: "down regulation of neuron death" EXACT [GOC:TermGenie] -synonym: "down regulation of neuronal cell death" EXACT [GOC:TermGenie] -synonym: "down-regulation of neuron cell death" EXACT [GOC:TermGenie] -synonym: "down-regulation of neuron death" EXACT [GOC:TermGenie] -synonym: "down-regulation of neuronal cell death" EXACT [GOC:TermGenie] -synonym: "downregulation of neuron cell death" EXACT [GOC:TermGenie] -synonym: "downregulation of neuron death" EXACT [GOC:TermGenie] -synonym: "downregulation of neuronal cell death" EXACT [GOC:TermGenie] -synonym: "inhibition of neuron cell death" NARROW [GOC:TermGenie] -synonym: "inhibition of neuron death" NARROW [GOC:TermGenie] -synonym: "inhibition of neuronal cell death" NARROW [GOC:TermGenie] -synonym: "negative regulation of neuron cell death" EXACT [GOC:TermGenie] -synonym: "negative regulation of neuronal cell death" EXACT [GOC:TermGenie] -is_a: GO:0048523 ! negative regulation of cellular process -is_a: GO:1901214 ! regulation of neuron death -intersection_of: GO:0065007 ! biological regulation -intersection_of: negatively_regulates GO:0070997 ! neuron death -relationship: negatively_regulates GO:0070997 ! neuron death -created_by: rph -creation_date: 2012-08-02T09:58:07Z - -[Term] -id: GO:1901216 -name: positive regulation of neuron death -namespace: biological_process -def: "Any process that activates or increases the frequency, rate or extent of neuron death." [GOC:rph, GOC:TermGenie] -synonym: "activation of neuron cell death" NARROW [GOC:TermGenie] -synonym: "activation of neuron death" NARROW [GOC:TermGenie] -synonym: "activation of neuronal cell death" NARROW [GOC:TermGenie] -synonym: "positive regulation of neuron cell death" EXACT [GOC:TermGenie] -synonym: "positive regulation of neuronal cell death" EXACT [GOC:TermGenie] -synonym: "up regulation of neuron cell death" EXACT [GOC:TermGenie] -synonym: "up regulation of neuron death" EXACT [GOC:TermGenie] -synonym: "up regulation of neuronal cell death" EXACT [GOC:TermGenie] -synonym: "up-regulation of neuron cell death" EXACT [GOC:TermGenie] -synonym: "up-regulation of neuron death" EXACT [GOC:TermGenie] -synonym: "up-regulation of neuronal cell death" EXACT [GOC:TermGenie] -synonym: "upregulation of neuron cell death" EXACT [GOC:TermGenie] -synonym: "upregulation of neuron death" EXACT [GOC:TermGenie] -synonym: "upregulation of neuronal cell death" EXACT [GOC:TermGenie] -is_a: GO:0048522 ! positive regulation of cellular process -is_a: GO:1901214 ! regulation of neuron death -intersection_of: GO:0065007 ! biological regulation -intersection_of: positively_regulates GO:0070997 ! neuron death -relationship: positively_regulates GO:0070997 ! neuron death -created_by: rph -creation_date: 2012-08-02T09:58:15Z - [Term] id: GO:1901219 name: regulation of cardiac chamber morphogenesis @@ -117808,6 +118483,18 @@ relationship: positively_regulates GO:0097360 ! chorionic trophoblast cell proli created_by: vk creation_date: 2012-10-01T10:04:41Z +[Term] +id: GO:1901472 +name: regulation of Golgi calcium ion export +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of Golgi calcium ion export." [GOC:TermGenie] +is_a: GO:0051279 ! regulation of release of sequestered calcium ion into cytosol +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:0061454 ! release of sequestered calcium ion into cytosol by Golgi +relationship: regulates GO:0061454 ! release of sequestered calcium ion into cytosol by Golgi +created_by: al +creation_date: 2012-10-03T07:26:03Z + [Term] id: GO:1901490 name: regulation of lymphangiogenesis @@ -119185,6 +119872,123 @@ relationship: positively_regulates GO:0034329 ! cell junction assembly created_by: tb creation_date: 2013-02-06T19:40:46Z +[Term] +id: GO:1901950 +name: dense core granule transport +namespace: biological_process +def: "The directed movement a dense core granule within a cell." [GOC:kmv, GOC:TermGenie, PMID:23358451] +comment: goslim_synapse +synonym: "dense core vesicle transport" EXACT [GOC:TermGenie] +is_a: GO:0016482 ! cytosolic transport +is_a: GO:0032253 ! dense core granule localization +is_a: GO:0051650 ! establishment of vesicle localization +intersection_of: GO:0006810 ! transport +intersection_of: has_primary_input GO:0031045 ! dense core granule +intersection_of: occurs_in GO:0005829 ! cytosol +created_by: pr +creation_date: 2013-02-19T13:00:52Z + +[Term] +id: GO:1901951 +name: regulation of anterograde dense core granule transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of anterograde dense core granule transport." [GOC:kmv, GOC:TermGenie, PMID:23358451] +is_a: GO:1901608 ! regulation of vesicle transport along microtubule +is_a: GO:1904809 ! regulation of dense core granule transport +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:1990048 ! anterograde neuronal dense core vesicle transport +relationship: regulates GO:1990048 ! anterograde neuronal dense core vesicle transport +created_by: pr +creation_date: 2013-02-19T13:36:21Z + +[Term] +id: GO:1901952 +name: negative regulation of anterograde dense core granule transport +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of anterograde dense core granule transport." [GOC:kmv, GOC:TermGenie, PMID:23358451] +synonym: "down regulation of anterograde dense core granule transport" EXACT [GOC:TermGenie] +synonym: "down-regulation of anterograde dense core granule transport" EXACT [GOC:TermGenie] +synonym: "downregulation of anterograde dense core granule transport" EXACT [GOC:TermGenie] +synonym: "inhibition of anterograde dense core granule transport" NARROW [GOC:TermGenie] +is_a: GO:1901609 ! negative regulation of vesicle transport along microtubule +is_a: GO:1901951 ! regulation of anterograde dense core granule transport +is_a: GO:1904810 ! negative regulation of dense core granule transport +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:1990048 ! anterograde neuronal dense core vesicle transport +relationship: negatively_regulates GO:1990048 ! anterograde neuronal dense core vesicle transport +created_by: pr +creation_date: 2013-02-19T13:36:30Z + +[Term] +id: GO:1901953 +name: positive regulation of anterograde dense core granule transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of anterograde dense core granule transport." [GOC:kmv, GOC:TermGenie, PMID:23358451] +synonym: "activation of anterograde dense core granule transport" NARROW [GOC:TermGenie] +synonym: "up regulation of anterograde dense core granule transport" EXACT [GOC:TermGenie] +synonym: "up-regulation of anterograde dense core granule transport" EXACT [GOC:TermGenie] +synonym: "upregulation of anterograde dense core granule transport" EXACT [GOC:TermGenie] +is_a: GO:1901610 ! positive regulation of vesicle transport along microtubule +is_a: GO:1901951 ! regulation of anterograde dense core granule transport +is_a: GO:1904811 ! positive regulation of dense core granule transport +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates GO:1990048 ! anterograde neuronal dense core vesicle transport +relationship: positively_regulates GO:1990048 ! anterograde neuronal dense core vesicle transport +created_by: pr +creation_date: 2013-02-19T13:36:35Z + +[Term] +id: GO:1901954 +name: regulation of retrograde dense core granule transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of retrograde dense core granule transport." [GOC:kmv, GOC:TermGenie, PMID:23358451] +is_a: GO:1901608 ! regulation of vesicle transport along microtubule +is_a: GO:1904809 ! regulation of dense core granule transport +is_a: GO:2001017 ! regulation of retrograde axon cargo transport +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:1990049 ! retrograde neuronal dense core vesicle transport +relationship: regulates GO:1990049 ! retrograde neuronal dense core vesicle transport +created_by: pr +creation_date: 2013-02-19T13:36:43Z + +[Term] +id: GO:1901955 +name: negative regulation of retrograde dense core granule transport +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of retrograde dense core granule transport." [GOC:kmv, GOC:TermGenie, PMID:23358451] +synonym: "down regulation of retrograde dense core granule transport" EXACT [GOC:TermGenie] +synonym: "down-regulation of retrograde dense core granule transport" EXACT [GOC:TermGenie] +synonym: "downregulation of retrograde dense core granule transport" EXACT [GOC:TermGenie] +synonym: "inhibition of retrograde dense core granule transport" NARROW [GOC:TermGenie] +is_a: GO:1901609 ! negative regulation of vesicle transport along microtubule +is_a: GO:1901954 ! regulation of retrograde dense core granule transport +is_a: GO:1904810 ! negative regulation of dense core granule transport +is_a: GO:2001018 ! negative regulation of retrograde axon cargo transport +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:1990049 ! retrograde neuronal dense core vesicle transport +relationship: negatively_regulates GO:1990049 ! retrograde neuronal dense core vesicle transport +created_by: pr +creation_date: 2013-02-19T13:36:47Z + +[Term] +id: GO:1901956 +name: positive regulation of retrograde dense core granule transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of retrograde dense core granule transport." [GOC:kmv, GOC:TermGenie, PMID:23358451] +synonym: "activation of retrograde dense core granule transport" NARROW [GOC:TermGenie] +synonym: "up regulation of retrograde dense core granule transport" EXACT [GOC:TermGenie] +synonym: "up-regulation of retrograde dense core granule transport" EXACT [GOC:TermGenie] +synonym: "upregulation of retrograde dense core granule transport" EXACT [GOC:TermGenie] +is_a: GO:1901610 ! positive regulation of vesicle transport along microtubule +is_a: GO:1901954 ! regulation of retrograde dense core granule transport +is_a: GO:1904811 ! positive regulation of dense core granule transport +is_a: GO:2001019 ! positive regulation of retrograde axon cargo transport +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates GO:1990049 ! retrograde neuronal dense core vesicle transport +relationship: positively_regulates GO:1990049 ! retrograde neuronal dense core vesicle transport +created_by: pr +creation_date: 2013-02-19T13:36:52Z + [Term] id: GO:1901963 name: regulation of cell proliferation involved in outflow tract morphogenesis @@ -120702,21 +121506,6 @@ relationship: positively_regulates GO:0035556 ! intracellular signal transductio created_by: bf creation_date: 2013-12-02T11:33:10Z -[Term] -id: GO:1902554 -name: serine/threonine protein kinase complex -namespace: cellular_component -def: "A protein complex which is capable of protein serine/threonine kinase activity." [GOC:bhm, GOC:TermGenie, PMID:18191223] -comment: An example is IRE1 in S. cerevisiae (UniProt ID P32361) in PMID:18191223 (inferred from direct assay). -synonym: "PDR16 complex dimer" RELATED [] -synonym: "PDR16 complex homodimer" RELATED [] -is_a: GO:1902911 ! protein kinase complex -intersection_of: GO:0032991 ! protein-containing complex -intersection_of: capable_of GO:0004674 ! protein serine/threonine kinase activity -relationship: capable_of GO:0004674 ! protein serine/threonine kinase activity -created_by: bhm -creation_date: 2013-12-06T16:06:12Z - [Term] id: GO:1902563 name: regulation of neutrophil activation @@ -120960,7 +121749,7 @@ synonym: "negative regulation of RNA anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of RNA biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of RNA formation" EXACT [GOC:TermGenie] synonym: "negative regulation of RNA synthesis" EXACT [GOC:TermGenie] -is_a: GO:0009890 ! negative regulation of biosynthetic process +is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process is_a: GO:0051253 ! negative regulation of RNA metabolic process is_a: GO:2001141 ! regulation of RNA biosynthetic process intersection_of: GO:0065007 ! biological regulation @@ -120998,7 +121787,7 @@ synonym: "upregulation of RNA biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of RNA biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of RNA formation" EXACT [GOC:TermGenie] synonym: "upregulation of RNA synthesis" EXACT [GOC:TermGenie] -is_a: GO:0009891 ! positive regulation of biosynthetic process +is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process is_a: GO:0051254 ! positive regulation of RNA metabolic process is_a: GO:2001141 ! regulation of RNA biosynthetic process intersection_of: GO:0065007 ! biological regulation @@ -121943,45 +122732,6 @@ relationship: positively_regulates GO:0009880 ! embryonic pattern specification created_by: mr creation_date: 2014-04-03T15:25:26Z -[Term] -id: GO:1902902 -name: negative regulation of autophagosome assembly -namespace: biological_process -def: "Any process that stops, prevents or reduces the frequency, rate or extent of autophagosome assembly." [GO_REF:0000058, GOC:als, GOC:autophagy, GOC:TermGenie, PMID:21975012] -synonym: "down regulation of autophagic vacuole assembly" EXACT [GOC:TermGenie] -synonym: "down regulation of autophagic vacuole formation" RELATED [GOC:TermGenie] -synonym: "down regulation of autophagosome biosynthesis" EXACT [GOC:TermGenie] -synonym: "down regulation of autophagosome formation" EXACT [GOC:TermGenie] -synonym: "down regulation of PAS formation" NARROW [GOC:TermGenie] -synonym: "down-regulation of autophagic vacuole assembly" EXACT [GOC:TermGenie] -synonym: "down-regulation of autophagic vacuole formation" RELATED [GOC:TermGenie] -synonym: "down-regulation of autophagosome biosynthesis" EXACT [GOC:TermGenie] -synonym: "down-regulation of autophagosome formation" EXACT [GOC:TermGenie] -synonym: "down-regulation of PAS formation" NARROW [GOC:TermGenie] -synonym: "downregulation of autophagic vacuole assembly" EXACT [GOC:TermGenie] -synonym: "downregulation of autophagic vacuole formation" RELATED [GOC:TermGenie] -synonym: "downregulation of autophagosome biosynthesis" EXACT [GOC:TermGenie] -synonym: "downregulation of autophagosome formation" EXACT [GOC:TermGenie] -synonym: "downregulation of PAS formation" NARROW [GOC:TermGenie] -synonym: "inhibition of autophagic vacuole assembly" NARROW [GOC:TermGenie] -synonym: "inhibition of autophagic vacuole formation" RELATED [GOC:TermGenie] -synonym: "inhibition of autophagosome biosynthesis" NARROW [GOC:TermGenie] -synonym: "inhibition of autophagosome formation" NARROW [GOC:TermGenie] -synonym: "inhibition of PAS formation" NARROW [GOC:TermGenie] -synonym: "negative regulation of autophagic vacuole assembly" EXACT [GOC:autophagy] -synonym: "negative regulation of autophagic vacuole formation" RELATED [GOC:TermGenie] -synonym: "negative regulation of autophagosome biosynthesis" EXACT [GOC:TermGenie] -synonym: "negative regulation of autophagosome formation" EXACT [GOC:TermGenie] -synonym: "negative regulation of PAS formation" NARROW [GOC:TermGenie] -is_a: GO:0016242 ! negative regulation of macroautophagy -is_a: GO:1902116 ! negative regulation of organelle assembly -is_a: GO:2000785 ! regulation of autophagosome assembly -intersection_of: GO:0065007 ! biological regulation -intersection_of: negatively_regulates GO:0000045 ! autophagosome assembly -relationship: negatively_regulates GO:0000045 ! autophagosome assembly -created_by: als -creation_date: 2014-04-15T10:37:40Z - [Term] id: GO:1902903 name: regulation of supramolecular fiber organization @@ -124663,6 +125413,63 @@ relationship: positively_regulates GO:0006308 ! DNA catabolic process created_by: sl creation_date: 2014-11-19T22:36:51Z +[Term] +id: GO:1903649 +name: regulation of cytoplasmic transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cytoplasmic transport." [GO_REF:0000058, GOC:TermGenie, PMID:25049409] +synonym: "regulation of cytoplasmic streaming" NARROW [GOC:TermGenie] +is_a: GO:0032386 ! regulation of intracellular transport +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:0016482 ! cytosolic transport +relationship: regulates GO:0016482 ! cytosolic transport +created_by: jl +creation_date: 2014-11-24T13:38:17Z + +[Term] +id: GO:1903650 +name: negative regulation of cytoplasmic transport +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cytoplasmic transport." [GO_REF:0000058, GOC:TermGenie, PMID:25049409] +synonym: "down regulation of cytoplasmic streaming" NARROW [GOC:TermGenie] +synonym: "down regulation of cytoplasmic transport" EXACT [GOC:TermGenie] +synonym: "down-regulation of cytoplasmic streaming" NARROW [GOC:TermGenie] +synonym: "down-regulation of cytoplasmic transport" EXACT [GOC:TermGenie] +synonym: "downregulation of cytoplasmic streaming" NARROW [GOC:TermGenie] +synonym: "downregulation of cytoplasmic transport" EXACT [GOC:TermGenie] +synonym: "inhibition of cytoplasmic streaming" NARROW [GOC:TermGenie] +synonym: "inhibition of cytoplasmic transport" NARROW [GOC:TermGenie] +synonym: "negative regulation of cytoplasmic streaming" NARROW [GOC:TermGenie] +is_a: GO:0032387 ! negative regulation of intracellular transport +is_a: GO:1903649 ! regulation of cytoplasmic transport +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:0016482 ! cytosolic transport +relationship: negatively_regulates GO:0016482 ! cytosolic transport +created_by: jl +creation_date: 2014-11-24T13:38:26Z + +[Term] +id: GO:1903651 +name: positive regulation of cytoplasmic transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cytoplasmic transport." [GO_REF:0000058, GOC:TermGenie, PMID:25049409] +synonym: "activation of cytoplasmic streaming" NARROW [GOC:TermGenie] +synonym: "activation of cytoplasmic transport" NARROW [GOC:TermGenie] +synonym: "positive regulation of cytoplasmic streaming" NARROW [GOC:TermGenie] +synonym: "up regulation of cytoplasmic streaming" NARROW [GOC:TermGenie] +synonym: "up regulation of cytoplasmic transport" EXACT [GOC:TermGenie] +synonym: "up-regulation of cytoplasmic streaming" NARROW [GOC:TermGenie] +synonym: "up-regulation of cytoplasmic transport" EXACT [GOC:TermGenie] +synonym: "upregulation of cytoplasmic streaming" NARROW [GOC:TermGenie] +synonym: "upregulation of cytoplasmic transport" EXACT [GOC:TermGenie] +is_a: GO:0032388 ! positive regulation of intracellular transport +is_a: GO:1903649 ! regulation of cytoplasmic transport +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates GO:0016482 ! cytosolic transport +relationship: positively_regulates GO:0016482 ! cytosolic transport +created_by: jl +creation_date: 2014-11-24T13:38:34Z + [Term] id: GO:1903680 name: acinar cell of sebaceous gland differentiation @@ -125048,6 +125855,44 @@ relationship: regulates GO:0003333 ! amino acid transmembrane transport created_by: al creation_date: 2015-01-08T17:42:18Z +[Term] +id: GO:1903804 +name: glycine import across plasma membrane +namespace: biological_process +alt_id: GO:0036233 +def: "The directed movement of glycine from outside of a cell, across the plasma membrane and into the cytosol." [GO_REF:0000075, GOC:TermGenie, PMID:23895341] +synonym: "glycine import" BROAD [] +synonym: "glycine import into cell" EXACT [] +is_a: GO:0015816 ! glycine transport +is_a: GO:0089718 ! amino acid import across plasma membrane +intersection_of: GO:0006810 ! transport +intersection_of: has_primary_input CHEBI:57305 +intersection_of: has_target_end_location GO:0005829 ! cytosol +intersection_of: has_target_start_location GO:0005576 ! extracellular region +intersection_of: results_in_transport_across GO:0005886 ! plasma membrane +created_by: bf +creation_date: 2012-05-11T01:16:45Z + +[Term] +id: GO:1903810 +name: L-histidine import across plasma membrane +namespace: biological_process +alt_id: GO:0061460 +alt_id: GO:0090466 +def: "The directed movement of L-histidine from outside of a cell, across the plasma membrane and into the cytosol." [GO_REF:0000075, GOC:TermGenie, PMID:23895341] +synonym: "histidine import" BROAD [] +synonym: "L-histidine import" BROAD [] +synonym: "L-histidine import into cell" EXACT [] +is_a: GO:0089709 ! L-histidine transmembrane transport +is_a: GO:0098739 ! import across plasma membrane +intersection_of: GO:0006810 ! transport +intersection_of: has_primary_input CHEBI:57595 +intersection_of: has_target_end_location GO:0005829 ! cytosol +intersection_of: has_target_start_location GO:0005576 ! extracellular region +intersection_of: results_in_transport_across GO:0005886 ! plasma membrane +created_by: dph +creation_date: 2012-10-05T10:20:50Z + [Term] id: GO:1903825 name: organic acid transmembrane transport @@ -125627,6 +126472,27 @@ relationship: positively_regulates GO:0001774 ! microglial cell activation created_by: nc creation_date: 2015-03-02T15:17:44Z +[Term] +id: GO:1903988 +name: iron ion export across plasma membrane +namespace: biological_process +alt_id: GO:1903414 +def: "The directed movement of iron ions from inside of a cell, across the plasma membrane and into the extracellular region." [GO_REF:0000074, GOC:BHF, GOC:kom, GOC:rl, GOC:TermGenie, PMID:15514116] +comment: An example of this is mouse ferroportin (symbol Slc40a1, UniProtKB identifier: Q9JHI9). +synonym: "ferrous iron export" NARROW [] +synonym: "ferrous iron export across plasma membrane" NARROW [] +synonym: "iron cation export" RELATED [] +synonym: "iron(2+) export" RELATED [] +is_a: GO:0034755 ! iron ion transmembrane transport +is_a: GO:0140115 ! export across plasma membrane +intersection_of: GO:0006810 ! transport +intersection_of: has_primary_input CHEBI:24875 +intersection_of: has_target_end_location GO:0005576 ! extracellular region +intersection_of: has_target_start_location GO:0005829 ! cytosol +intersection_of: results_in_transport_across GO:0005886 ! plasma membrane +created_by: rl +creation_date: 2014-09-03T13:01:37Z + [Term] id: GO:1904002 name: regulation of sebum secreting cell proliferation @@ -125898,6 +126764,66 @@ relationship: positively_regulates GO:1904019 ! epithelial cell apoptotic proces created_by: sl creation_date: 2015-03-13T22:05:53Z +[Term] +id: GO:1904038 +name: regulation of iron export across plasma membrane +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of export of iron ions from inside of a cell, across the plasma membrane and into the extracellular region." [GO_REF:0000058, GOC:BHF, GOC:kom, GOC:TermGenie, PMID:15514116] +synonym: "regulation of ferrous iron export" NARROW [] +synonym: "regulation of iron(2+) export" NARROW [] +is_a: GO:0034759 ! regulation of iron ion transmembrane transport +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:1903988 ! iron ion export across plasma membrane +relationship: regulates GO:1903988 ! iron ion export across plasma membrane +created_by: kom +creation_date: 2015-03-16T15:36:37Z + +[Term] +id: GO:1904039 +name: negative regulation of iron export across plasma membrane +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of export of iron ions from inside of a cell, across the plasma membrane and into the extracellular region." [GO_REF:0000058, GOC:BHF, GOC:kom, GOC:TermGenie, PMID:15514116] +synonym: "down regulation of ferrous iron export" NARROW [GOC:TermGenie] +synonym: "down regulation of iron(2+) export" NARROW [GOC:TermGenie] +synonym: "down-regulation of ferrous iron export" NARROW [GOC:TermGenie] +synonym: "down-regulation of iron(2+) export" NARROW [GOC:TermGenie] +synonym: "downregulation of ferrous iron export" NARROW [GOC:TermGenie] +synonym: "downregulation of iron(2+) export" NARROW [GOC:TermGenie] +synonym: "inhibition of ferrous iron export" NARROW [GOC:TermGenie] +synonym: "inhibition of iron(2+) export" NARROW [GOC:TermGenie] +synonym: "negative regulation of ferrous iron export" NARROW [GOC:TermGenie] +synonym: "negative regulation of iron(2+) export" NARROW [] +is_a: GO:0034760 ! negative regulation of iron ion transmembrane transport +is_a: GO:1904038 ! regulation of iron export across plasma membrane +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:1903988 ! iron ion export across plasma membrane +relationship: negatively_regulates GO:1903988 ! iron ion export across plasma membrane +created_by: kom +creation_date: 2015-03-16T15:36:43Z + +[Term] +id: GO:1904040 +name: positive regulation of iron export across plasma membrane +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of export of iron ions from inside of a cell, across the plasma membrane and into the extracellular region." [GO_REF:0000058, GOC:BHF, GOC:kom, GOC:TermGenie, PMID:15514116] +synonym: "activation of ferrous iron export" NARROW [GOC:TermGenie] +synonym: "activation of iron(2+) export" NARROW [GOC:TermGenie] +synonym: "positive regulation of ferrous iron export" NARROW [GOC:TermGenie] +synonym: "positive regulation of iron(2+) export" NARROW [] +synonym: "up regulation of ferrous iron export" NARROW [GOC:TermGenie] +synonym: "up regulation of iron(2+) export" NARROW [GOC:TermGenie] +synonym: "up-regulation of ferrous iron export" NARROW [GOC:TermGenie] +synonym: "up-regulation of iron(2+) export" NARROW [GOC:TermGenie] +synonym: "upregulation of ferrous iron export" NARROW [GOC:TermGenie] +synonym: "upregulation of iron(2+) export" NARROW [GOC:TermGenie] +is_a: GO:0034761 ! positive regulation of iron ion transmembrane transport +is_a: GO:1904038 ! regulation of iron export across plasma membrane +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates GO:1903988 ! iron ion export across plasma membrane +relationship: positively_regulates GO:1903988 ! iron ion export across plasma membrane +created_by: kom +creation_date: 2015-03-16T15:36:49Z + [Term] id: GO:1904044 name: response to aldosterone @@ -126168,76 +127094,6 @@ relationship: positively_regulates GO:0001834 ! trophectodermal cell proliferati created_by: tb creation_date: 2015-03-20T16:56:08Z -[Term] -id: GO:1904092 -name: regulation of autophagic cell death -namespace: biological_process -def: "Any process that modulates the frequency, rate or extent of autophagic cell death." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:25736836] -synonym: "regulation of autophagic death" BROAD [GOC:TermGenie] -synonym: "regulation of programmed cell death by autophagy" BROAD [GOC:TermGenie] -synonym: "regulation of programmed cell death by macroautophagy" EXACT [GOC:TermGenie] -synonym: "regulation of type II programmed cell death" RELATED [GOC:TermGenie] -is_a: GO:0043067 ! regulation of programmed cell death -intersection_of: GO:0065007 ! biological regulation -intersection_of: regulates GO:0048102 ! autophagic cell death -relationship: regulates GO:0048102 ! autophagic cell death -created_by: bhm -creation_date: 2015-03-26T16:41:32Z - -[Term] -id: GO:1904093 -name: negative regulation of autophagic cell death -namespace: biological_process -def: "Any process that stops, prevents or reduces the frequency, rate or extent of autophagic cell death." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:25736836] -synonym: "down regulation of autophagic cell death" EXACT [GOC:TermGenie] -synonym: "down regulation of programmed cell death by macroautophagy" EXACT [GOC:TermGenie] -synonym: "down regulation of type II programmed cell death" RELATED [GOC:TermGenie] -synonym: "down-regulation of autophagic cell death" EXACT [GOC:TermGenie] -synonym: "down-regulation of programmed cell death by macroautophagy" EXACT [GOC:TermGenie] -synonym: "down-regulation of type II programmed cell death" RELATED [GOC:TermGenie] -synonym: "downregulation of autophagic cell death" EXACT [GOC:TermGenie] -synonym: "downregulation of programmed cell death by macroautophagy" EXACT [GOC:TermGenie] -synonym: "downregulation of type II programmed cell death" RELATED [GOC:TermGenie] -synonym: "inhibition of autophagic cell death" NARROW [GOC:TermGenie] -synonym: "inhibition of programmed cell death by macroautophagy" NARROW [GOC:TermGenie] -synonym: "inhibition of type II programmed cell death" RELATED [GOC:TermGenie] -synonym: "negative regulation of programmed cell death by macroautophagy" EXACT [GOC:TermGenie] -synonym: "negative regulation of type II programmed cell death" RELATED [GOC:TermGenie] -is_a: GO:0043069 ! negative regulation of programmed cell death -is_a: GO:1904092 ! regulation of autophagic cell death -intersection_of: GO:0065007 ! biological regulation -intersection_of: negatively_regulates GO:0048102 ! autophagic cell death -relationship: negatively_regulates GO:0048102 ! autophagic cell death -created_by: bhm -creation_date: 2015-03-26T16:41:39Z - -[Term] -id: GO:1904094 -name: positive regulation of autophagic cell death -namespace: biological_process -def: "Any process that activates or increases the frequency, rate or extent of autophagic cell death." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:25736836] -synonym: "activation of autophagic cell death" NARROW [GOC:TermGenie] -synonym: "activation of programmed cell death by macroautophagy" NARROW [GOC:TermGenie] -synonym: "activation of type II programmed cell death" RELATED [GOC:TermGenie] -synonym: "positive regulation of programmed cell death by macroautophagy" EXACT [GOC:TermGenie] -synonym: "positive regulation of type II programmed cell death" RELATED [GOC:TermGenie] -synonym: "up regulation of autophagic cell death" EXACT [GOC:TermGenie] -synonym: "up regulation of programmed cell death by macroautophagy" EXACT [GOC:TermGenie] -synonym: "up regulation of type II programmed cell death" RELATED [GOC:TermGenie] -synonym: "up-regulation of autophagic cell death" EXACT [GOC:TermGenie] -synonym: "up-regulation of programmed cell death by macroautophagy" EXACT [GOC:TermGenie] -synonym: "up-regulation of type II programmed cell death" RELATED [GOC:TermGenie] -synonym: "upregulation of autophagic cell death" EXACT [GOC:TermGenie] -synonym: "upregulation of programmed cell death by macroautophagy" EXACT [GOC:TermGenie] -synonym: "upregulation of type II programmed cell death" RELATED [GOC:TermGenie] -is_a: GO:0043068 ! positive regulation of programmed cell death -is_a: GO:1904092 ! regulation of autophagic cell death -intersection_of: GO:0065007 ! biological regulation -intersection_of: positively_regulates GO:0048102 ! autophagic cell death -relationship: positively_regulates GO:0048102 ! autophagic cell death -created_by: bhm -creation_date: 2015-03-26T16:41:45Z - [Term] id: GO:1904106 name: protein localization to microvillus @@ -127851,6 +128707,73 @@ relationship: positively_regulates GO:0070588 ! calcium ion transmembrane transp created_by: sl creation_date: 2015-07-02T20:44:25Z +[Term] +id: GO:1904438 +name: regulation of iron ion import across plasma membrane +namespace: biological_process +alt_id: GO:1903989 +def: "Any process that modulates the frequency, rate or extent of iron ions import across plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:kom, GOC:TermGenie, PMID:18353247] +synonym: "regulation of ferrous ion import into cell" RELATED [GOC:TermGenie] +synonym: "regulation of ferrous iron import across plasma membrane" RELATED [] +synonym: "regulation of ferrous iron import into cell" RELATED [] +is_a: GO:0034759 ! regulation of iron ion transmembrane transport +is_a: GO:0060341 ! regulation of cellular localization +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:0098711 ! iron ion import across plasma membrane +relationship: regulates GO:0098711 ! iron ion import across plasma membrane +created_by: rl +creation_date: 2015-03-04T14:37:36Z + +[Term] +id: GO:1904439 +name: negative regulation of iron ion import across plasma membrane +namespace: biological_process +alt_id: GO:1903990 +def: "Any process that stops, prevents or reduces the frequency, rate or extent of iron ions import across plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:kom, GOC:TermGenie, PMID:18353247] +synonym: "down regulation of ferrous ion import into cell" RELATED [GOC:TermGenie] +synonym: "down regulation of ferrous iron import across plasma membrane" RELATED [GOC:TermGenie] +synonym: "down-regulation of ferrous ion import into cell" RELATED [GOC:TermGenie] +synonym: "down-regulation of ferrous iron import across plasma membrane" RELATED [GOC:TermGenie] +synonym: "downregulation of ferrous ion import into cell" RELATED [GOC:TermGenie] +synonym: "downregulation of ferrous iron import across plasma membrane" RELATED [GOC:TermGenie] +synonym: "inhibition of ferrous ion import into cell" NARROW [GOC:TermGenie] +synonym: "inhibition of ferrous iron import across plasma membrane" NARROW [GOC:TermGenie] +synonym: "negative regulation of ferrous ion import into cell" RELATED [GOC:TermGenie] +synonym: "negative regulation of ferrous iron import across plasma membrane" RELATED [] +synonym: "negative regulation of ferrous iron import into cell" RELATED [] +is_a: GO:0034760 ! negative regulation of iron ion transmembrane transport +is_a: GO:1904438 ! regulation of iron ion import across plasma membrane +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:0098711 ! iron ion import across plasma membrane +relationship: negatively_regulates GO:0098711 ! iron ion import across plasma membrane +created_by: rl +creation_date: 2015-07-06T13:49:58Z + +[Term] +id: GO:1904440 +name: positive regulation of iron ion import across plasma membrane +namespace: biological_process +alt_id: GO:1903991 +def: "Any process that activates or increases the frequency, rate or extent of iron ions import across plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:kom, GOC:TermGenie, PMID:18353247] +synonym: "activation of ferrous ion import into cell" NARROW [GOC:TermGenie] +synonym: "activation of ferrous iron import across plasma membrane" NARROW [GOC:TermGenie] +synonym: "positive regulation of ferrous ion import into cell" RELATED [GOC:TermGenie] +synonym: "positive regulation of ferrous iron import across plasma membrane" RELATED [] +synonym: "positive regulation of ferrous iron import into cell" RELATED [] +synonym: "up regulation of ferrous ion import into cell" RELATED [GOC:TermGenie] +synonym: "up regulation of ferrous iron import across plasma membrane" RELATED [GOC:TermGenie] +synonym: "up-regulation of ferrous ion import into cell" RELATED [GOC:TermGenie] +synonym: "up-regulation of ferrous iron import across plasma membrane" RELATED [GOC:TermGenie] +synonym: "upregulation of ferrous ion import into cell" RELATED [GOC:TermGenie] +synonym: "upregulation of ferrous iron import across plasma membrane" RELATED [GOC:TermGenie] +is_a: GO:0034761 ! positive regulation of iron ion transmembrane transport +is_a: GO:1904438 ! regulation of iron ion import across plasma membrane +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates GO:0098711 ! iron ion import across plasma membrane +relationship: positively_regulates GO:0098711 ! iron ion import across plasma membrane +created_by: rl +creation_date: 2015-07-06T13:50:04Z + [Term] id: GO:1904456 name: negative regulation of neuronal action potential @@ -128638,6 +129561,54 @@ relationship: has_primary_input CHEBI:16670 created_by: tb creation_date: 2015-09-22T18:50:41Z +[Term] +id: GO:1904688 +name: regulation of cytoplasmic translational initiation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cytoplasmic translational initiation." [GO_REF:0000058, GOC:TermGenie, PMID:12242291] +is_a: GO:0006446 ! regulation of translational initiation +is_a: GO:2000765 ! regulation of cytoplasmic translation +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:0002183 ! cytoplasmic translational initiation +relationship: regulates GO:0002183 ! cytoplasmic translational initiation +property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/21560" xsd:anyURI +created_by: dos +creation_date: 2015-09-25T14:39:38Z + +[Term] +id: GO:1904689 +name: negative regulation of cytoplasmic translational initiation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cytoplasmic translational initiation." [GO_REF:0000058, GOC:TermGenie, PMID:12242291] +synonym: "down regulation of cytoplasmic translational initiation" EXACT [GOC:TermGenie] +synonym: "down-regulation of cytoplasmic translational initiation" EXACT [GOC:TermGenie] +synonym: "downregulation of cytoplasmic translational initiation" EXACT [GOC:TermGenie] +synonym: "inhibition of cytoplasmic translational initiation" NARROW [GOC:TermGenie] +is_a: GO:0045947 ! negative regulation of translational initiation +is_a: GO:1904688 ! regulation of cytoplasmic translational initiation +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:0002183 ! cytoplasmic translational initiation +relationship: negatively_regulates GO:0002183 ! cytoplasmic translational initiation +created_by: dos +creation_date: 2015-09-25T14:39:44Z + +[Term] +id: GO:1904690 +name: positive regulation of cytoplasmic translational initiation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cytoplasmic translational initiation." [GO_REF:0000058, GOC:TermGenie, PMID:12242291] +synonym: "activation of cytoplasmic translational initiation" NARROW [GOC:TermGenie] +synonym: "up regulation of cytoplasmic translational initiation" EXACT [GOC:TermGenie] +synonym: "up-regulation of cytoplasmic translational initiation" EXACT [GOC:TermGenie] +synonym: "upregulation of cytoplasmic translational initiation" EXACT [GOC:TermGenie] +is_a: GO:0045948 ! positive regulation of translational initiation +is_a: GO:1904688 ! regulation of cytoplasmic translational initiation +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates GO:0002183 ! cytoplasmic translational initiation +relationship: positively_regulates GO:0002183 ! cytoplasmic translational initiation +created_by: dos +creation_date: 2015-09-25T14:39:50Z + [Term] id: GO:1904691 name: negative regulation of type B pancreatic cell proliferation @@ -128959,33 +129930,6 @@ relationship: results_in_movement_of CL:0000359 ! vascular associated smooth mus created_by: rph creation_date: 2015-10-15T09:56:00Z -[Term] -id: GO:1904745 -name: Atg1/ULK1 kinase complex assembly -namespace: biological_process -def: "The aggregation, arrangement and bonding together of a set of components to form an Atg1/UKL1 kinase complex." [GO_REF:0000079, GOC:dph, GOC:TermGenie, PMID:25139988] -synonym: "ATG1 kinase complex assembly" EXACT [GOC:TermGenie] -synonym: "ATG1 kinase complex formation" EXACT [GOC:TermGenie] -synonym: "ATG1-ATG13 complex assembly" EXACT [GOC:TermGenie] -synonym: "ATG1-ATG13 complex formation" EXACT [GOC:TermGenie] -synonym: "ATG1/ULK1 kinase complex formation" EXACT [GOC:TermGenie] -synonym: "ATG1/ULK1 signaling complex assembly" EXACT [GOC:TermGenie] -synonym: "ATG1/ULK1 signaling complex formation" EXACT [GOC:TermGenie] -synonym: "Atg1p signalling complex assembly" EXACT [GOC:TermGenie] -synonym: "Atg1p signalling complex formation" EXACT [GOC:TermGenie] -synonym: "ULK1 signaling complex assembly" EXACT [GOC:TermGenie] -synonym: "ULK1 signaling complex formation" EXACT [GOC:TermGenie] -synonym: "ULK1-ATG13-FIP200 complex assembly" EXACT [GOC:TermGenie] -synonym: "ULK1-ATG13-FIP200 complex formation" EXACT [GOC:TermGenie] -synonym: "ULK1-ATG13-RB1CC1 complex assembly" EXACT [GOC:TermGenie] -synonym: "ULK1-ATG13-RB1CC1 complex formation" EXACT [GOC:TermGenie] -is_a: GO:0065003 ! protein-containing complex assembly -intersection_of: GO:0022607 ! cellular component assembly -intersection_of: results_in_assembly_of GO:1990316 ! Atg1/ULK1 kinase complex -relationship: results_in_assembly_of GO:1990316 ! Atg1/ULK1 kinase complex -created_by: dph -creation_date: 2015-10-19T12:33:08Z - [Term] id: GO:1904746 name: negative regulation of apoptotic process involved in development @@ -129662,6 +130606,66 @@ relationship: positively_regulates GO:1990188 ! euchromatin binding created_by: nc creation_date: 2015-11-09T11:43:19Z +[Term] +id: GO:1904809 +name: regulation of dense core granule transport +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of dense core granule transport." [GO_REF:0000058, GOC:TermGenie, PMID:22699897] +comment: cdk-5 in C.elegans (G5ECH7) in PMID:22699897 (inferred from mutant phenotype). +synonym: "regulation of dense core vesicle transport" EXACT [GOC:TermGenie] +is_a: GO:1903649 ! regulation of cytoplasmic transport +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:1901950 ! dense core granule transport +relationship: regulates GO:1901950 ! dense core granule transport +created_by: es +creation_date: 2015-11-11T10:40:10Z + +[Term] +id: GO:1904810 +name: negative regulation of dense core granule transport +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of dense core granule transport." [GO_REF:0000058, GOC:TermGenie, PMID:22699897] +comment: cdk-5 in C.elegans (G5ECH7) in PMID:22699897 (inferred from mutant phenotype). +synonym: "down regulation of dense core granule transport" EXACT [GOC:TermGenie] +synonym: "down regulation of dense core vesicle transport" EXACT [GOC:TermGenie] +synonym: "down-regulation of dense core granule transport" EXACT [GOC:TermGenie] +synonym: "down-regulation of dense core vesicle transport" EXACT [GOC:TermGenie] +synonym: "downregulation of dense core granule transport" EXACT [GOC:TermGenie] +synonym: "downregulation of dense core vesicle transport" EXACT [GOC:TermGenie] +synonym: "inhibition of dense core granule transport" NARROW [GOC:TermGenie] +synonym: "inhibition of dense core vesicle transport" NARROW [GOC:TermGenie] +synonym: "negative regulation of dense core vesicle transport" EXACT [GOC:TermGenie] +is_a: GO:1903650 ! negative regulation of cytoplasmic transport +is_a: GO:1904809 ! regulation of dense core granule transport +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:1901950 ! dense core granule transport +relationship: negatively_regulates GO:1901950 ! dense core granule transport +created_by: es +creation_date: 2015-11-11T10:40:18Z + +[Term] +id: GO:1904811 +name: positive regulation of dense core granule transport +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of dense core granule transport." [GO_REF:0000058, GOC:TermGenie, PMID:22699897] +comment: cdk-5 in C.elegans (G5ECH7) in PMID:22699897 (inferred from mutant phenotype). +synonym: "activation of dense core granule transport" NARROW [GOC:TermGenie] +synonym: "activation of dense core vesicle transport" NARROW [GOC:TermGenie] +synonym: "positive regulation of dense core vesicle transport" EXACT [GOC:TermGenie] +synonym: "up regulation of dense core granule transport" EXACT [GOC:TermGenie] +synonym: "up regulation of dense core vesicle transport" EXACT [GOC:TermGenie] +synonym: "up-regulation of dense core granule transport" EXACT [GOC:TermGenie] +synonym: "up-regulation of dense core vesicle transport" EXACT [GOC:TermGenie] +synonym: "upregulation of dense core granule transport" EXACT [GOC:TermGenie] +synonym: "upregulation of dense core vesicle transport" EXACT [GOC:TermGenie] +is_a: GO:1903651 ! positive regulation of cytoplasmic transport +is_a: GO:1904809 ! regulation of dense core granule transport +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates GO:1901950 ! dense core granule transport +relationship: positively_regulates GO:1901950 ! dense core granule transport +created_by: es +creation_date: 2015-11-11T10:40:25Z + [Term] id: GO:1904817 name: serous membrane development @@ -130193,20 +131197,6 @@ relationship: results_in_acquisition_of_features_of CL:2000097 ! midbrain dopami created_by: bf creation_date: 2016-02-04T14:38:10Z -[Term] -id: GO:1904949 -name: ATPase complex -namespace: cellular_component -def: "A protein complex which is capable of ATPase activity." [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:9606181] -comment: An example of this is VPS4 in Saccharomyces cerevisiae (UniProt ID P52917) in PMID:9606181 (inferred from direct assay). -synonym: "VPS4 complex" NARROW [] -is_a: GO:1902494 ! catalytic complex -intersection_of: GO:0032991 ! protein-containing complex -intersection_of: capable_of GO:0016887 ! ATP hydrolysis activity -relationship: capable_of GO:0016887 ! ATP hydrolysis activity -created_by: bhm -creation_date: 2016-02-04T22:13:32Z - [Term] id: GO:1904950 name: negative regulation of establishment of protein localization @@ -130434,21 +131424,6 @@ relationship: positively_regulates GO:0042118 ! endothelial cell activation created_by: bc creation_date: 2016-02-29T16:16:25Z -[Term] -id: GO:1905037 -name: autophagosome organization -namespace: biological_process -def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an autophagosome." [GOC:bf, GOC:PARL, GOC:TermGenie, PMID:22186024] -synonym: "autophagic vacuole organization" EXACT [GOC:TermGenie] -synonym: "initial autophagic vacuole organization" RELATED [GOC:TermGenie] -is_a: GO:0007033 ! vacuole organization -intersection_of: GO:0016043 ! cellular component organization -intersection_of: results_in_organization_of GO:0005776 ! autophagosome -relationship: part_of GO:0016236 ! macroautophagy -relationship: results_in_organization_of GO:0005776 ! autophagosome -created_by: bf -creation_date: 2016-03-08T14:18:10Z - [Term] id: GO:1905039 name: carboxylic acid transmembrane transport @@ -130745,25 +131720,6 @@ relationship: positively_regulates GO:0101010 ! pulmonary blood vessel remodelin created_by: bc creation_date: 2016-04-06T13:07:42Z -[Term] -id: GO:1905114 -name: cell surface receptor signaling pathway involved in cell-cell signaling -namespace: biological_process -def: "Any cell surface receptor signaling pathway that is involved in cell-cell signaling." [GO_REF:0000060, GOC:TermGenie, ISBN:0-7167-3051-0] -synonym: "cell surface receptor linked signal transduction involved in cell-cell signaling" EXACT [GOC:TermGenie] -synonym: "cell surface receptor linked signal transduction involved in cell-cell signalling" EXACT [GOC:TermGenie] -synonym: "cell surface receptor linked signaling pathway involved in cell-cell signaling" EXACT [GOC:TermGenie] -synonym: "cell surface receptor linked signaling pathway involved in cell-cell signalling" EXACT [GOC:TermGenie] -synonym: "cell surface receptor linked signalling pathway involved in cell-cell signaling" EXACT [GOC:TermGenie] -synonym: "cell surface receptor linked signalling pathway involved in cell-cell signalling" EXACT [GOC:TermGenie] -synonym: "cell surface receptor signaling pathway involved in cell-cell signalling" EXACT [GOC:TermGenie] -is_a: GO:0007166 ! cell surface receptor signaling pathway -intersection_of: GO:0007166 ! cell surface receptor signaling pathway -intersection_of: part_of GO:0007267 ! cell-cell signaling -relationship: part_of GO:0007267 ! cell-cell signaling -created_by: dos -creation_date: 2016-04-06T16:59:57Z - [Term] id: GO:1905126 name: regulation of axo-dendritic protein transport @@ -131363,7 +132319,7 @@ name: regulation of platelet formation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of platelet formation." [GO_REF:0000058, GOC:TermGenie, PMID:10606160] synonym: "regulation of platelet extrusion" EXACT [GOC:TermGenie] -is_a: GO:0010769 ! regulation of cell morphogenesis involved in differentiation +is_a: GO:0022604 ! regulation of cell morphogenesis is_a: GO:0045637 ! regulation of myeloid cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0030220 ! platelet formation @@ -131407,7 +132363,7 @@ synonym: "up-regulation of platelet extrusion" EXACT [GOC:TermGenie] synonym: "up-regulation of platelet formation" EXACT [GOC:TermGenie] synonym: "upregulation of platelet extrusion" EXACT [GOC:TermGenie] synonym: "upregulation of platelet formation" EXACT [GOC:TermGenie] -is_a: GO:0010770 ! positive regulation of cell morphogenesis involved in differentiation +is_a: GO:0010770 ! positive regulation of cell morphogenesis is_a: GO:0045639 ! positive regulation of myeloid cell differentiation is_a: GO:1905219 ! regulation of platelet formation intersection_of: GO:0065007 ! biological regulation @@ -133633,6 +134589,37 @@ relationship: positively_regulates GO:0048844 ! artery morphogenesis created_by: rph creation_date: 2016-11-09T12:20:01Z +[Term] +id: GO:1905664 +name: regulation of calcium ion import across plasma membrane +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of calcium ion import across plasma membrane." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:17640527] +comment: An example of this is PPP3CA in human (Q08209) in 17640527 (inferred from direct assay). +is_a: GO:1903169 ! regulation of calcium ion transmembrane transport +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:0098703 ! calcium ion import across plasma membrane +relationship: regulates GO:0098703 ! calcium ion import across plasma membrane +created_by: bhm +creation_date: 2016-11-11T09:26:06Z + +[Term] +id: GO:1905665 +name: positive regulation of calcium ion import across plasma membrane +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of calcium ion import across plasma membrane." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:17640527] +comment: An example of this is PPP3CA in human (Q08209) in 17640527 (inferred from direct assay). +synonym: "activation of calcium ion import across plasma membrane" NARROW [GOC:TermGenie] +synonym: "up regulation of calcium ion import across plasma membrane" EXACT [GOC:TermGenie] +synonym: "up-regulation of calcium ion import across plasma membrane" EXACT [GOC:TermGenie] +synonym: "upregulation of calcium ion import across plasma membrane" EXACT [GOC:TermGenie] +is_a: GO:1904427 ! positive regulation of calcium ion transmembrane transport +is_a: GO:1905664 ! regulation of calcium ion import across plasma membrane +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates GO:0098703 ! calcium ion import across plasma membrane +relationship: positively_regulates GO:0098703 ! calcium ion import across plasma membrane +created_by: bhm +creation_date: 2016-11-11T09:26:23Z + [Term] id: GO:1905671 name: regulation of lysosome organization @@ -134130,217 +135117,6 @@ relationship: negatively_regulates GO:0007020 ! microtubule nucleation created_by: hbye creation_date: 2017-01-17T12:00:56Z -[Term] -id: GO:1905864 -name: regulation of Atg1/ULK1 kinase complex assembly -namespace: biological_process -def: "Any process that modulates the frequency, rate or extent of Atg1/ULK1 kinase complex assembly." [GO_REF:0000058, GOC:autophagy, GOC:mf, GOC:TermGenie, PMID:26567215] -synonym: "regulation of ATG1 kinase complex assembly" EXACT [GOC:TermGenie] -synonym: "regulation of ATG1 kinase complex formation" EXACT [GOC:TermGenie] -synonym: "regulation of ATG1-ATG13 complex assembly" EXACT [GOC:TermGenie] -synonym: "regulation of ATG1-ATG13 complex formation" EXACT [GOC:TermGenie] -synonym: "regulation of ATG1/ULK1 kinase complex formation" EXACT [GOC:TermGenie] -synonym: "regulation of ATG1/ULK1 signaling complex assembly" EXACT [GOC:TermGenie] -synonym: "regulation of ATG1/ULK1 signaling complex formation" EXACT [GOC:TermGenie] -synonym: "regulation of Atg1p signalling complex assembly" EXACT [GOC:TermGenie] -synonym: "regulation of Atg1p signalling complex formation" EXACT [GOC:TermGenie] -synonym: "regulation of ULK1 signaling complex assembly" EXACT [GOC:TermGenie] -synonym: "regulation of ULK1 signaling complex formation" EXACT [GOC:TermGenie] -synonym: "regulation of ULK1-ATG13-FIP200 complex assembly" EXACT [GOC:TermGenie] -synonym: "regulation of ULK1-ATG13-FIP200 complex formation" EXACT [GOC:TermGenie] -synonym: "regulation of ULK1-ATG13-RB1CC1 complex assembly" EXACT [GOC:TermGenie] -synonym: "regulation of ULK1-ATG13-RB1CC1 complex formation" EXACT [GOC:TermGenie] -is_a: GO:0043254 ! regulation of protein-containing complex assembly -intersection_of: GO:0065007 ! biological regulation -intersection_of: regulates GO:1904745 ! Atg1/ULK1 kinase complex assembly -relationship: regulates GO:1904745 ! Atg1/ULK1 kinase complex assembly -created_by: pr -creation_date: 2017-01-26T13:23:26Z - -[Term] -id: GO:1905865 -name: negative regulation of Atg1/ULK1 kinase complex assembly -namespace: biological_process -def: "Any process that stops, prevents or reduces the frequency, rate or extent of Atg1/ULK1 kinase complex assembly." [GO_REF:0000058, GOC:autophagy, GOC:mf, GOC:TermGenie, PMID:26567215] -synonym: "down regulation of ATG1 kinase complex assembly" EXACT [GOC:TermGenie] -synonym: "down regulation of ATG1 kinase complex formation" EXACT [GOC:TermGenie] -synonym: "down regulation of ATG1-ATG13 complex assembly" EXACT [GOC:TermGenie] -synonym: "down regulation of ATG1-ATG13 complex formation" EXACT [GOC:TermGenie] -synonym: "down regulation of ATG1/ULK1 kinase complex assembly" EXACT [GOC:TermGenie] -synonym: "down regulation of ATG1/ULK1 kinase complex formation" EXACT [GOC:TermGenie] -synonym: "down regulation of ATG1/ULK1 signaling complex assembly" EXACT [GOC:TermGenie] -synonym: "down regulation of ATG1/ULK1 signaling complex formation" EXACT [GOC:TermGenie] -synonym: "down regulation of Atg1p signalling complex assembly" EXACT [GOC:TermGenie] -synonym: "down regulation of Atg1p signalling complex formation" EXACT [GOC:TermGenie] -synonym: "down regulation of ULK1 signaling complex assembly" EXACT [GOC:TermGenie] -synonym: "down regulation of ULK1 signaling complex formation" EXACT [GOC:TermGenie] -synonym: "down regulation of ULK1-ATG13-FIP200 complex assembly" EXACT [GOC:TermGenie] -synonym: "down regulation of ULK1-ATG13-FIP200 complex formation" EXACT [GOC:TermGenie] -synonym: "down regulation of ULK1-ATG13-RB1CC1 complex assembly" EXACT [GOC:TermGenie] -synonym: "down regulation of ULK1-ATG13-RB1CC1 complex formation" EXACT [GOC:TermGenie] -synonym: "down-regulation of ATG1 kinase complex assembly" EXACT [GOC:TermGenie] -synonym: "down-regulation of ATG1 kinase complex formation" EXACT [GOC:TermGenie] -synonym: "down-regulation of ATG1-ATG13 complex assembly" EXACT [GOC:TermGenie] -synonym: "down-regulation of ATG1-ATG13 complex formation" EXACT [GOC:TermGenie] -synonym: "down-regulation of ATG1/ULK1 kinase complex assembly" EXACT [GOC:TermGenie] -synonym: "down-regulation of ATG1/ULK1 kinase complex formation" EXACT [GOC:TermGenie] -synonym: "down-regulation of ATG1/ULK1 signaling complex assembly" EXACT [GOC:TermGenie] -synonym: "down-regulation of ATG1/ULK1 signaling complex formation" EXACT [GOC:TermGenie] -synonym: "down-regulation of Atg1p signalling complex assembly" EXACT [GOC:TermGenie] -synonym: "down-regulation of Atg1p signalling complex formation" EXACT [GOC:TermGenie] -synonym: "down-regulation of ULK1 signaling complex assembly" EXACT [GOC:TermGenie] -synonym: "down-regulation of ULK1 signaling complex formation" EXACT [GOC:TermGenie] -synonym: "down-regulation of ULK1-ATG13-FIP200 complex assembly" EXACT [GOC:TermGenie] -synonym: "down-regulation of ULK1-ATG13-FIP200 complex formation" EXACT [GOC:TermGenie] -synonym: "down-regulation of ULK1-ATG13-RB1CC1 complex assembly" EXACT [GOC:TermGenie] -synonym: "down-regulation of ULK1-ATG13-RB1CC1 complex formation" EXACT [GOC:TermGenie] -synonym: "downregulation of ATG1 kinase complex assembly" EXACT [GOC:TermGenie] -synonym: "downregulation of ATG1 kinase complex formation" EXACT [GOC:TermGenie] -synonym: "downregulation of ATG1-ATG13 complex assembly" EXACT [GOC:TermGenie] -synonym: "downregulation of ATG1-ATG13 complex formation" EXACT [GOC:TermGenie] -synonym: "downregulation of ATG1/ULK1 kinase complex assembly" EXACT [GOC:TermGenie] -synonym: "downregulation of ATG1/ULK1 kinase complex formation" EXACT [GOC:TermGenie] -synonym: "downregulation of ATG1/ULK1 signaling complex assembly" EXACT [GOC:TermGenie] -synonym: "downregulation of ATG1/ULK1 signaling complex formation" EXACT [GOC:TermGenie] -synonym: "downregulation of Atg1p signalling complex assembly" EXACT [GOC:TermGenie] -synonym: "downregulation of Atg1p signalling complex formation" EXACT [GOC:TermGenie] -synonym: "downregulation of ULK1 signaling complex assembly" EXACT [GOC:TermGenie] -synonym: "downregulation of ULK1 signaling complex formation" EXACT [GOC:TermGenie] -synonym: "downregulation of ULK1-ATG13-FIP200 complex assembly" EXACT [GOC:TermGenie] -synonym: "downregulation of ULK1-ATG13-FIP200 complex formation" EXACT [GOC:TermGenie] -synonym: "downregulation of ULK1-ATG13-RB1CC1 complex assembly" EXACT [GOC:TermGenie] -synonym: "downregulation of ULK1-ATG13-RB1CC1 complex formation" EXACT [GOC:TermGenie] -synonym: "inhibition of ATG1 kinase complex assembly" NARROW [GOC:TermGenie] -synonym: "inhibition of ATG1 kinase complex formation" NARROW [GOC:TermGenie] -synonym: "inhibition of ATG1-ATG13 complex assembly" NARROW [GOC:TermGenie] -synonym: "inhibition of ATG1-ATG13 complex formation" NARROW [GOC:TermGenie] -synonym: "inhibition of ATG1/ULK1 kinase complex assembly" NARROW [GOC:TermGenie] -synonym: "inhibition of ATG1/ULK1 kinase complex formation" NARROW [GOC:TermGenie] -synonym: "inhibition of ATG1/ULK1 signaling complex assembly" NARROW [GOC:TermGenie] -synonym: "inhibition of ATG1/ULK1 signaling complex formation" NARROW [GOC:TermGenie] -synonym: "inhibition of Atg1p signalling complex assembly" NARROW [GOC:TermGenie] -synonym: "inhibition of Atg1p signalling complex formation" NARROW [GOC:TermGenie] -synonym: "inhibition of ULK1 signaling complex assembly" NARROW [GOC:TermGenie] -synonym: "inhibition of ULK1 signaling complex formation" NARROW [GOC:TermGenie] -synonym: "inhibition of ULK1-ATG13-FIP200 complex assembly" NARROW [GOC:TermGenie] -synonym: "inhibition of ULK1-ATG13-FIP200 complex formation" NARROW [GOC:TermGenie] -synonym: "inhibition of ULK1-ATG13-RB1CC1 complex assembly" NARROW [GOC:TermGenie] -synonym: "inhibition of ULK1-ATG13-RB1CC1 complex formation" NARROW [GOC:TermGenie] -synonym: "negative regulation of ATG1 kinase complex assembly" EXACT [GOC:TermGenie] -synonym: "negative regulation of ATG1 kinase complex formation" EXACT [GOC:TermGenie] -synonym: "negative regulation of ATG1-ATG13 complex assembly" EXACT [GOC:TermGenie] -synonym: "negative regulation of ATG1-ATG13 complex formation" EXACT [GOC:TermGenie] -synonym: "negative regulation of ATG1/ULK1 kinase complex formation" EXACT [GOC:TermGenie] -synonym: "negative regulation of ATG1/ULK1 signaling complex assembly" EXACT [GOC:TermGenie] -synonym: "negative regulation of ATG1/ULK1 signaling complex formation" EXACT [GOC:TermGenie] -synonym: "negative regulation of Atg1p signalling complex assembly" EXACT [GOC:TermGenie] -synonym: "negative regulation of Atg1p signalling complex formation" EXACT [GOC:TermGenie] -synonym: "negative regulation of ULK1 signaling complex assembly" EXACT [GOC:TermGenie] -synonym: "negative regulation of ULK1 signaling complex formation" EXACT [GOC:TermGenie] -synonym: "negative regulation of ULK1-ATG13-FIP200 complex assembly" EXACT [GOC:TermGenie] -synonym: "negative regulation of ULK1-ATG13-FIP200 complex formation" EXACT [GOC:TermGenie] -synonym: "negative regulation of ULK1-ATG13-RB1CC1 complex assembly" EXACT [GOC:TermGenie] -synonym: "negative regulation of ULK1-ATG13-RB1CC1 complex formation" EXACT [GOC:TermGenie] -is_a: GO:0031333 ! negative regulation of protein-containing complex assembly -is_a: GO:1905864 ! regulation of Atg1/ULK1 kinase complex assembly -intersection_of: GO:0065007 ! biological regulation -intersection_of: negatively_regulates GO:1904745 ! Atg1/ULK1 kinase complex assembly -relationship: negatively_regulates GO:1904745 ! Atg1/ULK1 kinase complex assembly -created_by: pr -creation_date: 2017-01-26T13:23:35Z - -[Term] -id: GO:1905866 -name: positive regulation of Atg1/ULK1 kinase complex assembly -namespace: biological_process -def: "Any process that activates or increases the frequency, rate or extent of Atg1/ULK1 kinase complex assembly." [GO_REF:0000058, GOC:autophagy, GOC:mf, GOC:TermGenie, PMID:26567215] -synonym: "activation of ATG1 kinase complex assembly" NARROW [GOC:TermGenie] -synonym: "activation of ATG1 kinase complex formation" NARROW [GOC:TermGenie] -synonym: "activation of ATG1-ATG13 complex assembly" NARROW [GOC:TermGenie] -synonym: "activation of ATG1-ATG13 complex formation" NARROW [GOC:TermGenie] -synonym: "activation of ATG1/ULK1 kinase complex assembly" NARROW [GOC:TermGenie] -synonym: "activation of ATG1/ULK1 kinase complex formation" NARROW [GOC:TermGenie] -synonym: "activation of ATG1/ULK1 signaling complex assembly" NARROW [GOC:TermGenie] -synonym: "activation of ATG1/ULK1 signaling complex formation" NARROW [GOC:TermGenie] -synonym: "activation of Atg1p signalling complex assembly" NARROW [GOC:TermGenie] -synonym: "activation of Atg1p signalling complex formation" NARROW [GOC:TermGenie] -synonym: "activation of ULK1 signaling complex assembly" NARROW [GOC:TermGenie] -synonym: "activation of ULK1 signaling complex formation" NARROW [GOC:TermGenie] -synonym: "activation of ULK1-ATG13-FIP200 complex assembly" NARROW [GOC:TermGenie] -synonym: "activation of ULK1-ATG13-FIP200 complex formation" NARROW [GOC:TermGenie] -synonym: "activation of ULK1-ATG13-RB1CC1 complex assembly" NARROW [GOC:TermGenie] -synonym: "activation of ULK1-ATG13-RB1CC1 complex formation" NARROW [GOC:TermGenie] -synonym: "positive regulation of ATG1 kinase complex assembly" EXACT [GOC:TermGenie] -synonym: "positive regulation of ATG1 kinase complex formation" EXACT [GOC:TermGenie] -synonym: "positive regulation of ATG1-ATG13 complex assembly" EXACT [GOC:TermGenie] -synonym: "positive regulation of ATG1-ATG13 complex formation" EXACT [GOC:TermGenie] -synonym: "positive regulation of ATG1/ULK1 kinase complex formation" EXACT [GOC:TermGenie] -synonym: "positive regulation of ATG1/ULK1 signaling complex assembly" EXACT [GOC:TermGenie] -synonym: "positive regulation of ATG1/ULK1 signaling complex formation" EXACT [GOC:TermGenie] -synonym: "positive regulation of Atg1p signalling complex assembly" EXACT [GOC:TermGenie] -synonym: "positive regulation of Atg1p signalling complex formation" EXACT [GOC:TermGenie] -synonym: "positive regulation of ULK1 signaling complex assembly" EXACT [GOC:TermGenie] -synonym: "positive regulation of ULK1 signaling complex formation" EXACT [GOC:TermGenie] -synonym: "positive regulation of ULK1-ATG13-FIP200 complex assembly" EXACT [GOC:TermGenie] -synonym: "positive regulation of ULK1-ATG13-FIP200 complex formation" EXACT [GOC:TermGenie] -synonym: "positive regulation of ULK1-ATG13-RB1CC1 complex assembly" EXACT [GOC:TermGenie] -synonym: "positive regulation of ULK1-ATG13-RB1CC1 complex formation" EXACT [GOC:TermGenie] -synonym: "up regulation of ATG1 kinase complex assembly" EXACT [GOC:TermGenie] -synonym: "up regulation of ATG1 kinase complex formation" EXACT [GOC:TermGenie] -synonym: "up regulation of ATG1-ATG13 complex assembly" EXACT [GOC:TermGenie] -synonym: "up regulation of ATG1-ATG13 complex formation" EXACT [GOC:TermGenie] -synonym: "up regulation of ATG1/ULK1 kinase complex assembly" EXACT [GOC:TermGenie] -synonym: "up regulation of ATG1/ULK1 kinase complex formation" EXACT [GOC:TermGenie] -synonym: "up regulation of ATG1/ULK1 signaling complex assembly" EXACT [GOC:TermGenie] -synonym: "up regulation of ATG1/ULK1 signaling complex formation" EXACT [GOC:TermGenie] -synonym: "up regulation of Atg1p signalling complex assembly" EXACT [GOC:TermGenie] -synonym: "up regulation of Atg1p signalling complex formation" EXACT [GOC:TermGenie] -synonym: "up regulation of ULK1 signaling complex assembly" EXACT [GOC:TermGenie] -synonym: "up regulation of ULK1 signaling complex formation" EXACT [GOC:TermGenie] -synonym: "up regulation of ULK1-ATG13-FIP200 complex assembly" EXACT [GOC:TermGenie] -synonym: "up regulation of ULK1-ATG13-FIP200 complex formation" EXACT [GOC:TermGenie] -synonym: "up regulation of ULK1-ATG13-RB1CC1 complex assembly" EXACT [GOC:TermGenie] -synonym: "up regulation of ULK1-ATG13-RB1CC1 complex formation" EXACT [GOC:TermGenie] -synonym: "up-regulation of ATG1 kinase complex assembly" EXACT [GOC:TermGenie] -synonym: "up-regulation of ATG1 kinase complex formation" EXACT [GOC:TermGenie] -synonym: "up-regulation of ATG1-ATG13 complex assembly" EXACT [GOC:TermGenie] -synonym: "up-regulation of ATG1-ATG13 complex formation" EXACT [GOC:TermGenie] -synonym: "up-regulation of ATG1/ULK1 kinase complex assembly" EXACT [GOC:TermGenie] -synonym: "up-regulation of ATG1/ULK1 kinase complex formation" EXACT [GOC:TermGenie] -synonym: "up-regulation of ATG1/ULK1 signaling complex assembly" EXACT [GOC:TermGenie] -synonym: "up-regulation of ATG1/ULK1 signaling complex formation" EXACT [GOC:TermGenie] -synonym: "up-regulation of Atg1p signalling complex assembly" EXACT [GOC:TermGenie] -synonym: "up-regulation of Atg1p signalling complex formation" EXACT [GOC:TermGenie] -synonym: "up-regulation of ULK1 signaling complex assembly" EXACT [GOC:TermGenie] -synonym: "up-regulation of ULK1 signaling complex formation" EXACT [GOC:TermGenie] -synonym: "up-regulation of ULK1-ATG13-FIP200 complex assembly" EXACT [GOC:TermGenie] -synonym: "up-regulation of ULK1-ATG13-FIP200 complex formation" EXACT [GOC:TermGenie] -synonym: "up-regulation of ULK1-ATG13-RB1CC1 complex assembly" EXACT [GOC:TermGenie] -synonym: "up-regulation of ULK1-ATG13-RB1CC1 complex formation" EXACT [GOC:TermGenie] -synonym: "upregulation of ATG1 kinase complex assembly" EXACT [GOC:TermGenie] -synonym: "upregulation of ATG1 kinase complex formation" EXACT [GOC:TermGenie] -synonym: "upregulation of ATG1-ATG13 complex assembly" EXACT [GOC:TermGenie] -synonym: "upregulation of ATG1-ATG13 complex formation" EXACT [GOC:TermGenie] -synonym: "upregulation of ATG1/ULK1 kinase complex assembly" EXACT [GOC:TermGenie] -synonym: "upregulation of ATG1/ULK1 kinase complex formation" EXACT [GOC:TermGenie] -synonym: "upregulation of ATG1/ULK1 signaling complex assembly" EXACT [GOC:TermGenie] -synonym: "upregulation of ATG1/ULK1 signaling complex formation" EXACT [GOC:TermGenie] -synonym: "upregulation of Atg1p signalling complex assembly" EXACT [GOC:TermGenie] -synonym: "upregulation of Atg1p signalling complex formation" EXACT [GOC:TermGenie] -synonym: "upregulation of ULK1 signaling complex assembly" EXACT [GOC:TermGenie] -synonym: "upregulation of ULK1 signaling complex formation" EXACT [GOC:TermGenie] -synonym: "upregulation of ULK1-ATG13-FIP200 complex assembly" EXACT [GOC:TermGenie] -synonym: "upregulation of ULK1-ATG13-FIP200 complex formation" EXACT [GOC:TermGenie] -synonym: "upregulation of ULK1-ATG13-RB1CC1 complex assembly" EXACT [GOC:TermGenie] -synonym: "upregulation of ULK1-ATG13-RB1CC1 complex formation" EXACT [GOC:TermGenie] -is_a: GO:0031334 ! positive regulation of protein-containing complex assembly -is_a: GO:1905864 ! regulation of Atg1/ULK1 kinase complex assembly -intersection_of: GO:0065007 ! biological regulation -intersection_of: positively_regulates GO:1904745 ! Atg1/ULK1 kinase complex assembly -relationship: positively_regulates GO:1904745 ! Atg1/ULK1 kinase complex assembly -created_by: pr -creation_date: 2017-01-26T13:23:44Z - [Term] id: GO:1905867 name: epididymis development @@ -134602,6 +135378,66 @@ relationship: results_in_morphogenesis_of UBERON:0003295 ! pharyngeal gland created_by: rz creation_date: 2017-02-03T14:39:10Z +[Term] +id: GO:1905912 +name: regulation of calcium ion export across plasma membrane +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of calcium ion export across the plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22362515] +synonym: "regulation of calcium ion efflux from cell" EXACT [GOC:TermGenie] +synonym: "regulation of calcium ion export from cell" EXACT [] +is_a: GO:1903169 ! regulation of calcium ion transmembrane transport +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:1990034 ! calcium ion export across plasma membrane +relationship: regulates GO:1990034 ! calcium ion export across plasma membrane +created_by: rph +creation_date: 2017-02-07T13:20:39Z + +[Term] +id: GO:1905913 +name: negative regulation of calcium ion export across plasma membrane +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of calcium ion export across the plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22362515] +synonym: "down regulation of calcium ion efflux from cell" EXACT [GOC:TermGenie] +synonym: "down regulation of calcium ion export from cell" EXACT [GOC:TermGenie] +synonym: "down-regulation of calcium ion efflux from cell" EXACT [GOC:TermGenie] +synonym: "down-regulation of calcium ion export from cell" EXACT [GOC:TermGenie] +synonym: "downregulation of calcium ion efflux from cell" EXACT [GOC:TermGenie] +synonym: "downregulation of calcium ion export from cell" EXACT [GOC:TermGenie] +synonym: "inhibition of calcium ion efflux from cell" NARROW [GOC:TermGenie] +synonym: "inhibition of calcium ion export from cell" NARROW [GOC:TermGenie] +synonym: "negative regulation of calcium ion efflux from cell" EXACT [GOC:TermGenie] +synonym: "negative regulation of calcium ion export from cell" EXACT [] +is_a: GO:1903170 ! negative regulation of calcium ion transmembrane transport +is_a: GO:1905912 ! regulation of calcium ion export across plasma membrane +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:1990034 ! calcium ion export across plasma membrane +relationship: negatively_regulates GO:1990034 ! calcium ion export across plasma membrane +created_by: rph +creation_date: 2017-02-07T13:20:48Z + +[Term] +id: GO:1905914 +name: positive regulation of calcium ion export across plasma membrane +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of calcium ion export across the plasma membrane." [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:22362515] +synonym: "activation of calcium ion efflux from cell" NARROW [GOC:TermGenie] +synonym: "activation of calcium ion export from cell" NARROW [GOC:TermGenie] +synonym: "positive regulation of calcium ion efflux from cell" EXACT [GOC:TermGenie] +synonym: "positive regulation of calcium ion export from cell" EXACT [] +synonym: "up regulation of calcium ion efflux from cell" EXACT [GOC:TermGenie] +synonym: "up regulation of calcium ion export from cell" EXACT [GOC:TermGenie] +synonym: "up-regulation of calcium ion efflux from cell" EXACT [GOC:TermGenie] +synonym: "up-regulation of calcium ion export from cell" EXACT [GOC:TermGenie] +synonym: "upregulation of calcium ion efflux from cell" EXACT [GOC:TermGenie] +synonym: "upregulation of calcium ion export from cell" EXACT [GOC:TermGenie] +is_a: GO:1904427 ! positive regulation of calcium ion transmembrane transport +is_a: GO:1905912 ! regulation of calcium ion export across plasma membrane +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates GO:1990034 ! calcium ion export across plasma membrane +relationship: positively_regulates GO:1990034 ! calcium ion export across plasma membrane +created_by: rph +creation_date: 2017-02-07T13:20:56Z + [Term] id: GO:1905921 name: regulation of acetylcholine biosynthetic process @@ -134866,6 +135702,24 @@ relationship: positively_regulates GO:0051592 ! response to calcium ion created_by: bc creation_date: 2017-02-13T10:56:49Z +[Term] +id: GO:1905949 +name: negative regulation of calcium ion import across plasma membrane +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of calcium ion import across plasma membrane." [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:17640527] +comment: An example of this is PPP3CA in human (Q08209) in PMID:17640527 (inferred from direct assay). +synonym: "down regulation of calcium ion import across plasma membrane" EXACT [GOC:TermGenie] +synonym: "down-regulation of calcium ion import across plasma membrane" EXACT [GOC:TermGenie] +synonym: "downregulation of calcium ion import across plasma membrane" EXACT [GOC:TermGenie] +synonym: "inhibition of calcium ion import across plasma membrane" NARROW [GOC:TermGenie] +is_a: GO:1903170 ! negative regulation of calcium ion transmembrane transport +is_a: GO:1905664 ! regulation of calcium ion import across plasma membrane +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:0098703 ! calcium ion import across plasma membrane +relationship: negatively_regulates GO:0098703 ! calcium ion import across plasma membrane +created_by: bhm +creation_date: 2017-02-17T09:42:30Z + [Term] id: GO:1905952 name: regulation of lipid localization @@ -134997,6 +135851,61 @@ relationship: occurs_in CL:0009001 ! compound eye retinal cell created_by: pr creation_date: 2012-12-12T10:21:07Z +[Term] +id: GO:1990034 +name: calcium ion export across plasma membrane +namespace: biological_process +def: "The directed movement of calcium ions from inside of a cell, across the plasma membrane and into the extracellular region." [GOC:mah, PMID:2145281] +synonym: "calcium ion efflux from cell" EXACT [GOC:vw, PMID:2145281] +synonym: "calcium ion export from cell" EXACT [] +is_a: GO:0070588 ! calcium ion transmembrane transport +is_a: GO:0140115 ! export across plasma membrane +intersection_of: GO:0006810 ! transport +intersection_of: has_primary_input CHEBI:29108 +intersection_of: has_target_end_location GO:0005576 ! extracellular region +intersection_of: has_target_start_location GO:0005829 ! cytosol +intersection_of: results_in_transport_across GO:0005886 ! plasma membrane +created_by: mah +creation_date: 2013-02-07T13:01:29Z + +[Term] +id: GO:1990048 +name: anterograde neuronal dense core vesicle transport +namespace: biological_process +def: "The directed movement of substances in neuronal dense core vesicles along axonal microtubules towards the presynapse." [GOC:kmv, PMID:23358451] +subset: goslim_synapse +synonym: "anterograde dense core granule trafficking" EXACT [] +synonym: "anterograde dense core granule transport" EXACT [] +is_a: GO:0008089 ! anterograde axonal transport +is_a: GO:0047496 ! vesicle transport along microtubule +is_a: GO:0099519 ! dense core granule cytoskeletal transport +intersection_of: GO:0006810 ! transport +intersection_of: has_primary_input GO:0098992 ! neuronal dense core vesicle +intersection_of: has_target_end_location GO:0098793 ! presynapse +intersection_of: occurs_in GO:1904115 ! axon cytoplasm +intersection_of: results_in_transport_along GO:0005874 ! microtubule +relationship: has_primary_input GO:0098992 ! neuronal dense core vesicle + +[Term] +id: GO:1990049 +name: retrograde neuronal dense core vesicle transport +namespace: biological_process +def: "The directed movement of neuronal dense core vesicles along axonal microtubules towards the cell body." [GOC:kmv, PMID:23358451, PMID:24762653] +subset: goslim_synapse +synonym: "retrograde dense core granule trafficking" EXACT [] +synonym: "retrograde dense core granule transport" EXACT [] +is_a: GO:0008090 ! retrograde axonal transport +is_a: GO:0047496 ! vesicle transport along microtubule +is_a: GO:0099519 ! dense core granule cytoskeletal transport +intersection_of: GO:0006810 ! transport +intersection_of: has_primary_input GO:0098992 ! neuronal dense core vesicle +intersection_of: has_target_start_location GO:0098793 ! presynapse +intersection_of: occurs_in GO:1904115 ! axon cytoplasm +intersection_of: results_in_transport_along GO:0005874 ! microtubule +relationship: has_primary_input GO:0098992 ! neuronal dense core vesicle +created_by: pr +creation_date: 2013-02-19T13:31:44Z + [Term] id: GO:1990086 name: lens fiber cell apoptotic process @@ -135103,29 +136012,6 @@ relationship: has_target_end_location GO:0000785 ! chromatin created_by: mah creation_date: 2014-01-30T15:55:34Z -[Term] -id: GO:1990316 -name: Atg1/ULK1 kinase complex -namespace: cellular_component -alt_id: GO:0034273 -alt_id: GO:0070969 -def: "A protein complex consisting of Atg1 (or Atg1 homologs e.g. ULK1, ULK2 in mammals) and Atg13 along with other proteins that regulate its function (e.g. Atg17 in yeast or RB1CC1(FIP200) in mammals). This complex has serine/threonine protein kinase activity and is involved in autophagosome formation." [GOC:bhm, GOC:DOS, GOC:rb, PMID:15743910, PMID:19211835, PMID:19258318, PMID:19597335, PMID:22885598] -synonym: "ATG1 kinase complex" EXACT [] -synonym: "ATG1-ATG13 complex" EXACT [] -synonym: "ATG1/ULK1 signaling complex" EXACT [] -synonym: "Atg1p signalling complex" EXACT [] -synonym: "autophagy-initiation complex" EXACT [GOC:autophagy, GOC:pad, GOC:PARL, PMID:26754330] -synonym: "ULK complex" EXACT [PMID:28816597] -synonym: "ULK1 complex" EXACT [PMID:26921696] -synonym: "ULK1 signaling complex" EXACT [] -synonym: "ULK1-ATG13-FIP200 complex" EXACT [] -synonym: "ULK1-ATG13-RB1CC1 complex" EXACT [] -is_a: GO:1902554 ! serine/threonine protein kinase complex -relationship: capable_of_part_of GO:0000045 ! autophagosome assembly -relationship: part_of GO:0005737 ! cytoplasm -created_by: bhm -creation_date: 2014-03-14T10:55:11Z - [Term] id: GO:1990351 name: transporter complex @@ -135183,6 +136069,32 @@ relationship: part_of GO:0010039 ! response to iron ion created_by: sart creation_date: 2014-08-19T10:12:46Z +[Term] +id: GO:1990502 +name: dense core granule maturation +namespace: biological_process +def: "Steps required to transform a dense core granule generated at the trans-Golgi network into a fully formed and transmissible dense core granule. Dense core granule maturation proceeds through clathrin-mediated membrane remodeling events and is essential for efficient processing of cargo within dense core granules as well as for removing factors that might otherwise interfere with dense core granule trafficking and exocytosis." [GOC:kmv, PMID:22654674] +synonym: "dense core vesicle maturation" EXACT [] +is_a: GO:0061792 ! secretory granule maturation +intersection_of: GO:0021700 ! developmental maturation +intersection_of: results_in_maturation_of GO:0031045 ! dense core granule +relationship: results_in_maturation_of GO:0031045 ! dense core granule +created_by: kmv +creation_date: 2014-09-30T20:35:11Z + +[Term] +id: GO:1990580 +name: regulation of cytoplasmic translational termination +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cytoplasmic translational termination." [PMID:11570975] +is_a: GO:0006449 ! regulation of translational termination +is_a: GO:2000765 ! regulation of cytoplasmic translation +intersection_of: GO:0050789 ! regulation of biological process +intersection_of: regulates GO:0002184 ! cytoplasmic translational termination +relationship: regulates GO:0002184 ! cytoplasmic translational termination +created_by: vw +creation_date: 2014-12-10T15:48:55Z + [Term] id: GO:1990654 name: sebum secreting cell proliferation @@ -138867,6 +139779,44 @@ relationship: positively_regulates GO:0072497 ! mesenchymal stem cell differenti created_by: yaf creation_date: 2011-06-14T02:31:34Z +[Term] +id: GO:2000765 +name: regulation of cytoplasmic translation +namespace: biological_process +def: "Any process that modulates the frequency, rate or extent of cytoplasmic translation." [GOC:obol] +is_a: GO:0006417 ! regulation of translation +intersection_of: GO:0065007 ! biological regulation +intersection_of: regulates GO:0002181 ! cytoplasmic translation +relationship: regulates GO:0002181 ! cytoplasmic translation +created_by: vw +creation_date: 2011-06-20T10:39:19Z + +[Term] +id: GO:2000766 +name: negative regulation of cytoplasmic translation +namespace: biological_process +def: "Any process that stops, prevents or reduces the frequency, rate or extent of cytoplasmic translation." [GOC:obol] +is_a: GO:0017148 ! negative regulation of translation +is_a: GO:2000765 ! regulation of cytoplasmic translation +intersection_of: GO:0065007 ! biological regulation +intersection_of: negatively_regulates GO:0002181 ! cytoplasmic translation +relationship: negatively_regulates GO:0002181 ! cytoplasmic translation +created_by: vw +creation_date: 2011-06-20T10:39:23Z + +[Term] +id: GO:2000767 +name: positive regulation of cytoplasmic translation +namespace: biological_process +def: "Any process that activates or increases the frequency, rate or extent of cytoplasmic translation." [GOC:obol] +is_a: GO:0045727 ! positive regulation of translation +is_a: GO:2000765 ! regulation of cytoplasmic translation +intersection_of: GO:0065007 ! biological regulation +intersection_of: positively_regulates GO:0002181 ! cytoplasmic translation +relationship: positively_regulates GO:0002181 ! cytoplasmic translation +created_by: vw +creation_date: 2011-06-20T10:39:26Z + [Term] id: GO:2000768 name: positive regulation of nephron tubule epithelial cell differentiation @@ -138880,44 +139830,6 @@ relationship: positively_regulates GO:0072160 ! nephron tubule epithelial cell d created_by: yaf creation_date: 2011-06-22T11:55:06Z -[Term] -id: GO:2000785 -name: regulation of autophagosome assembly -namespace: biological_process -def: "Any process that modulates the frequency, rate or extent of autophagosome assembly." [GOC:autophagy, GOC:BHF] -synonym: "regulation of autophagic vacuole assembly" EXACT [GOC:autophagy] -synonym: "regulation of autophagic vacuole formation" RELATED [GOC:obol] -synonym: "regulation of autophagosome biosynthesis" EXACT [GOC:obol] -synonym: "regulation of autophagosome formation" EXACT [GOC:obol] -synonym: "regulation of PAS formation" RELATED [GOC:obol] -is_a: GO:0044088 ! regulation of vacuole organization -is_a: GO:1902115 ! regulation of organelle assembly -intersection_of: GO:0065007 ! biological regulation -intersection_of: regulates GO:0000045 ! autophagosome assembly -relationship: regulates GO:0000045 ! autophagosome assembly -created_by: rl -creation_date: 2011-06-24T11:19:08Z - -[Term] -id: GO:2000786 -name: positive regulation of autophagosome assembly -namespace: biological_process -def: "Any process that activates or increases the frequency, rate or extent of autophagic vacuole assembly." [GOC:autophagy, GOC:BHF] -synonym: "positive regulation of autophagic vacuole assembly" EXACT [GOC:autophagy] -synonym: "positive regulation of autophagic vacuole formation" RELATED [GOC:obol] -synonym: "positive regulation of autophagosome biosynthesis" EXACT [GOC:obol] -synonym: "positive regulation of autophagosome formation" EXACT [GOC:obol] -synonym: "positive regulation of PAS formation" RELATED [GOC:obol] -is_a: GO:0016239 ! positive regulation of macroautophagy -is_a: GO:0044090 ! positive regulation of vacuole organization -is_a: GO:1902117 ! positive regulation of organelle assembly -is_a: GO:2000785 ! regulation of autophagosome assembly -intersection_of: GO:0065007 ! biological regulation -intersection_of: positively_regulates GO:0000045 ! autophagosome assembly -relationship: positively_regulates GO:0000045 ! autophagosome assembly -created_by: rl -creation_date: 2011-06-24T11:19:12Z - [Term] id: GO:2000790 name: regulation of mesenchymal cell proliferation involved in lung development @@ -139899,7 +140811,7 @@ synonym: "regulation of RNA anabolism" EXACT [GOC:obol] synonym: "regulation of RNA biosynthesis" EXACT [GOC:obol] synonym: "regulation of RNA formation" EXACT [GOC:obol] synonym: "regulation of RNA synthesis" EXACT [GOC:obol] -is_a: GO:0009889 ! regulation of biosynthetic process +is_a: GO:0010556 ! regulation of macromolecule biosynthetic process is_a: GO:0051252 ! regulation of RNA metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0032774 ! RNA biosynthetic process @@ -140396,95 +141308,6 @@ relationship: positively_regulates GO:0005261 ! monoatomic cation channel activi created_by: vk creation_date: 2011-12-07T07:14:57Z -[Term] -id: IAO:0000027 -name: data item -def: "An information content entity that is intended to be a truthful statement about something (modulo, e.g., measurement precision or other systematic errors) and is constructed/acquired by a method which reliably tends to produce (approximately) truthful statements." [] -is_a: IAO:0000030 ! information content entity -property_value: editor_note "2/2/2009 Alan and Bjoern discussing FACS run output data. This is a data item because it is about the cell population. Each element records an event and is typically further composed a set of measurment data items that record the fluorescent intensity stimulated by one of the lasers." xsd:string -property_value: editor_note "2009-03-16: data item deliberatly ambiguous: we merged data set and datum to be one entity, not knowing how to define singular versus plural. So data item is more general than datum." xsd:string -property_value: editor_note "2009-03-16: removed datum as alternative term as datum specifically refers to singular form, and is thus not an exact synonym." xsd:string -property_value: editor_note "2014-03-31: See discussion at http://odontomachus.wordpress.com/2014/03/30/aboutness-objects-propositions/" xsd:string -property_value: editor_note "JAR: datum -- well, this will be very tricky to define, but maybe some \ninformation-like stuff that might be put into a computer and that is \nmeant, by someone, to denote and/or to be interpreted by some \nprocess... I would include lists, tables, sentences... I think I might \ndefer to Barry, or to Brian Cantwell Smith\n\nJAR: A data item is an approximately justified approximately true approximate belief" xsd:string -property_value: IAO:0000111 "data item" xsd:string -property_value: IAO:0000112 "Data items include counts of things, analyte concentrations, and statistical summaries." xsd:string -property_value: IAO:0000114 IAO:0000125 -property_value: IAO:0000117 "PERSON: Alan Ruttenberg" xsd:string -property_value: IAO:0000117 "PERSON: Chris Stoeckert" xsd:string -property_value: IAO:0000117 "PERSON: Jonathan Rees" xsd:string -property_value: IAO:0000118 "data" xsd:string - -[Term] -id: IAO:0000028 -name: symbol -def: "An information content entity that is a mark(s) or character(s) used as a conventional representation of another entity." [] -is_a: IAO:0000030 ! information content entity -property_value: editor_note "20091104, MC: this needs work and will most probably change" xsd:string -property_value: editor_note "2014-03-31: We would like to have a deeper analysis of 'mark' and 'sign' in the future (see https://github.com/information-artifact-ontology/IAO/issues/154)." xsd:string -property_value: IAO:0000111 "symbol" xsd:string -property_value: IAO:0000112 "a serial number such as \"12324X\"" xsd:string -property_value: IAO:0000112 "a stop sign" xsd:string -property_value: IAO:0000112 "a written proper name such as \"OBI\"" xsd:string -property_value: IAO:0000114 IAO:0000125 -property_value: IAO:0000117 "PERSON: James A. Overton" xsd:string -property_value: IAO:0000117 "PERSON: Jonathan Rees" xsd:string -property_value: IAO:0000119 "based on Oxford English Dictionary" xsd:string - -[Term] -id: IAO:0000030 -name: information content entity -def: "A generically dependent continuant that is about some thing." [] -is_a: BFO:0000031 ! generically dependent continuant -relationship: IAO:0000136 BFO:0000001 ! is about -property_value: editor_note "2014-03-10: The use of \"thing\" is intended to be general enough to include universals and configurations (see https://groups.google.com/d/msg/information-ontology/GBxvYZCk1oc/-L6B5fSBBTQJ)." xsd:string -property_value: editor_note "information_content_entity 'is_encoded_in' some digital_entity in obi before split (040907). information_content_entity 'is_encoded_in' some physical_document in obi before split (040907).\n\nPrevious. An information content entity is a non-realizable information entity that 'is encoded in' some digital or physical entity." xsd:string -property_value: IAO:0000111 "information content entity" xsd:string -property_value: IAO:0000112 "Examples of information content entites include journal articles, data, graphical layouts, and graphs." xsd:string -property_value: IAO:0000114 IAO:0000122 -property_value: IAO:0000117 "PERSON: Chris Stoeckert" xsd:string -property_value: IAO:0000119 "OBI_0000142" xsd:string - -[Term] -id: IAO:0000078 -name: curation status specification -def: "The curation status of the term. The allowed values come from an enumerated list of predefined terms. See the specification of these instances for more detailed definitions of each enumerated value." [] -is_a: IAO:0000102 ! data about an ontology part -property_value: editor_note "Better to represent curation as a process with parts and then relate labels to that process (in IAO meeting)" xsd:string -property_value: IAO:0000111 "curation status specification" xsd:string -property_value: IAO:0000114 IAO:0000125 -property_value: IAO:0000117 "PERSON:Bill Bug" xsd:string -property_value: IAO:0000119 "GROUP:OBI:" xsd:string -property_value: IAO:0000119 "OBI_0000266" xsd:string - -[Term] -id: IAO:0000102 -name: data about an ontology part -def: "Data about an ontology part is a data item about a part of an ontology, for example a term" [] -is_a: IAO:0000027 ! data item -property_value: IAO:0000111 "data about an ontology part" xsd:string -property_value: IAO:0000117 "Person:Alan Ruttenberg" xsd:string - -[Term] -id: IAO:0000225 -name: obsolescence reason specification -def: "The reason for which a term has been deprecated. The allowed values come from an enumerated list of predefined terms. See the specification of these instances for more detailed definitions of each enumerated value." [] -is_a: IAO:0000102 ! data about an ontology part -property_value: editor_note "The creation of this class has been inspired in part by Werner Ceusters' paper, Applying evolutionary terminology auditing to the Gene Ontology." xsd:string -property_value: IAO:0000111 "obsolescence reason specification" xsd:string -property_value: IAO:0000114 IAO:0000125 -property_value: IAO:0000117 "PERSON: Alan Ruttenberg" xsd:string -property_value: IAO:0000117 "PERSON: Melanie Courtot" xsd:string - -[Term] -id: IAO:0000409 -name: denotator type -def: "A denotator type indicates how a term should be interpreted from an ontological perspective." [] -is_a: IAO:0000102 ! data about an ontology part -property_value: IAO:0000111 "denotator type" xsd:string -property_value: IAO:0000112 "The Basic Formal Ontology ontology makes a distinction between Universals and defined classes, where the formal are \"natural kinds\" and the latter arbitrary collections of entities." xsd:string -property_value: IAO:0000117 "Alan Ruttenberg" xsd:string -property_value: IAO:0000119 "Barry Smith, Werner Ceusters" xsd:string - [Term] id: NCBITaxon:1 name: root @@ -183423,7 +184246,6 @@ xref: UMLS:C1179179 {source="ncithesaurus:Respiratory_Bronchiole_Epithelium"} is_a: UBERON:0002051 ! epithelium of bronchiole intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0002188 ! respiratory bronchiole -relationship: has_part CL:0000158 {source="FMA"} ! club cell relationship: part_of UBERON:0002188 ! respiratory bronchiole relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens @@ -183454,6 +184276,8 @@ intersection_of: UBERON:0007844 ! cartilage element intersection_of: part_of UBERON:0002185 ! bronchus relationship: composed_primarily_of UBERON:0001994 {source="MP"} ! hyaline cartilage tissue relationship: contributes_to_morphology_of UBERON:0002185 ! bronchus +relationship: dc-contributor https://orcid.org/0000-0001-6677-8489 +relationship: has_part CL:0019002 ! tracheobronchial chondrocyte relationship: part_of UBERON:0002185 ! bronchus relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens @@ -183504,7 +184328,7 @@ xref: UMLS:C1179400 {source="ncithesaurus:Terminal_Bronchiole_Epithelium"} is_a: UBERON:0002051 ! epithelium of bronchiole intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0002187 ! terminal bronchiole -relationship: has_part CL:0000158 {source="FMA"} ! club cell +relationship: dc-contributor https://orcid.org/0000-0001-6677-8489 relationship: part_of UBERON:0002187 ! terminal bronchiole relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens property_value: UBPROP:0000008 "A pseudostratified epithelium, containing basal cells, stem cells of the airway, submucosal glands and cartilage rings, is limited to the trachea and large lobar airways in the mouse (Morrisey and Hogan, 2010). This more complex epithelium extends to terminal bronchioles in the human[DOI:10.1242/dev.115469]" xsd:string @@ -185679,7 +186503,10 @@ is_a: UBERON:0008397 ! tracheobronchial epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0002186 ! bronchiole relationship: contributes_to_morphology_of UBERON:0002186 ! bronchiole +relationship: dc-contributor https://orcid.org/0000-0001-6677-8489 +relationship: has_part CL:0000158 ! club cell relationship: has_part CL:0002145 {source="FMA"} ! ciliated columnar cell of tracheobronchial tree +relationship: has_part CL:1000271 ! lung ciliated cell relationship: part_of UBERON:0005039 ! mucosa of bronchiole relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens @@ -188135,6 +188962,7 @@ relationship: has_part UBERON:0001956 ! cartilage of bronchus relationship: has_part UBERON:0004242 ! bronchus smooth muscle relationship: has_part UBERON:0004883 ! lung mesenchyme relationship: has_part UBERON:8410043 ! bronchus submucosal gland +relationship: overlaps UBERON:8600017 ! bronchopulmonary segment relationship: part_of UBERON:0000101 {source="FMA"} ! lobe of lung relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens relationship: proximally_connected_to UBERON:0002183 ! lobar bronchus @@ -188205,7 +189033,7 @@ xref: VHOG:0000675 xref: Wikipedia:Bronchiole is_a: UBERON:0000117 ! respiratory tube relationship: branching_part_of UBERON:0007196 {source="FMA"} ! tracheobronchial tree -relationship: part_of UBERON:0010368 {source="ncit"} ! pulmonary lobule +relationship: part_of UBERON:0002048 {source="MA"} ! lung property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/d/db/Alveoli_diagram.png" xsd:anyURI property_value: UBPROP:0000007 "bronchiolar" xsd:string property_value: UBPROP:0000010 "lacks submucosa and cartilage plates; they have 3 layers: mucosa, muscular layer and outer layer" xsd:string {source="ISBN:0123813611"} @@ -188215,7 +189043,7 @@ property_value: UBPROP:0000012 "In FMA2 and FMA3, lobular bronchiole is an exact id: UBERON:0002187 name: terminal bronchiole namespace: uberon -def: "The last conducting structure of non-respiratory bronchioles; after this point, the airways have alveoli in their walls." [ISBN:0-397-51047-0, MGI:cwg, MP:0002268] +def: "A bronchiole that is part of a secondary pulmonary lobule and the last conducting structure of a non-respiratory bronchiole; after this point, the airways have alveoli in their walls." [ISBN:0-397-51047-0, MGI:cwg, MP:0002268, PMID:16543587] subset: human_reference_atlas subset: pheno_slim subset: uberon_slim @@ -188231,6 +189059,9 @@ xref: SCTID:278981008 xref: UMLS:C0225666 {source="ncithesaurus:Terminal_Bronchiole"} xref: Wikipedia:Terminal_bronchiole is_a: UBERON:0002186 ! bronchiole +relationship: distally_connected_to UBERON:0002188 ! respiratory bronchiole +relationship: distally_connected_to UBERON:0008874 ! pulmonary acinus +relationship: part_of UBERON:0010369 ! secondary pulmonary lobule relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens property_value: depicted_by "https://upload.wikimedia.org/wikipedia/commons/d/db/Alveoli_diagram.png" xsd:anyURI @@ -190925,6 +191756,10 @@ is_a: UBERON:0000115 ! lung epithelium is_a: UBERON:0002031 ! epithelium of bronchus intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0002183 ! lobar bronchus +relationship: dc-contributor https://orcid.org/0000-0001-6677-8489 +relationship: has_part CL:0002329 ! basal epithelial cell of tracheobronchial tree +relationship: has_part CL:0002332 ! ciliated cell of the bronchus +relationship: has_part CL:0017000 ! pulmonary ionocyte relationship: part_of UBERON:0002183 ! lobar bronchus relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens @@ -190947,8 +191782,17 @@ xref: FMA:86626 xref: MA:0001850 is_a: UBERON:0000115 ! lung epithelium is_a: UBERON:0002031 ! epithelium of bronchus +is_a: UBERON:0006934 ! sensory epithelium intersection_of: UBERON:0000483 ! epithelium intersection_of: part_of UBERON:0002184 ! segmental bronchus +relationship: dc-contributor https://orcid.org/0000-0001-6677-8489 +relationship: has_part CL:0000158 ! club cell +relationship: has_part CL:0002208 ! brush cell of bronchus +relationship: has_part CL:0002329 ! basal epithelial cell of tracheobronchial tree +relationship: has_part CL:0002332 ! ciliated cell of the bronchus +relationship: has_part CL:0017000 ! pulmonary ionocyte +relationship: has_part CL:1000143 ! lung goblet cell +relationship: has_part CL:1000223 ! lung neuroendocrine cell relationship: part_of UBERON:0002184 ! segmental bronchus relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens @@ -209752,6 +210596,8 @@ xref: UMLS:C1707055 {source="ncithesaurus:Bronchus_Smooth_Muscle_Tissue"} is_a: UBERON:0004233 ! lower respiratory tract smooth muscle intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: part_of UBERON:0002185 ! bronchus +relationship: dc-contributor https://orcid.org/0000-0001-6677-8489 +relationship: has_part CL:0002598 ! bronchial smooth muscle cell relationship: part_of UBERON:0002185 ! bronchus relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens @@ -212098,6 +212944,8 @@ xref: FMA:261051 is_a: UBERON:0004515 ! smooth muscle tissue of bronchiole intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: part_of UBERON:0002187 ! terminal bronchiole +relationship: dc-contributor https://orcid.org/0000-0001-6677-8489 +relationship: has_part CL:4033017 ! bronchiolar smooth muscle cell relationship: part_of UBERON:0002187 ! terminal bronchiole relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens @@ -212111,6 +212959,8 @@ xref: FMA:261055 is_a: UBERON:0004515 ! smooth muscle tissue of bronchiole intersection_of: UBERON:0001135 ! smooth muscle tissue intersection_of: part_of UBERON:0002188 ! respiratory bronchiole +relationship: dc-contributor https://orcid.org/0000-0001-6677-8489 +relationship: has_part CL:4033017 ! bronchiolar smooth muscle cell relationship: part_of UBERON:0002188 ! respiratory bronchiole relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens @@ -215892,6 +216742,8 @@ xref: EMAPA:32698 is_a: UBERON:0004883 ! lung mesenchyme intersection_of: UBERON:0003104 ! mesenchyme intersection_of: part_of UBERON:0002183 ! lobar bronchus +relationship: dc-contributor https://orcid.org/0000-0001-6677-8489 +relationship: has_part CL:0019019 ! tracheobronchial smooth muscle cell relationship: part_of UBERON:0002183 ! lobar bronchus relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens @@ -221046,6 +221898,28 @@ xref: TAO:0000357 xref: ZFA:0000357 is_a: UBERON:0004001 ! olfactory bulb layer +[Term] +id: UBERON:0005378 +name: olfactory bulb granule cell layer +namespace: uberon +def: "The granule cell layer contains multiple small round neurons that lack axons. Long dendritic processes of the neurons reach the more superficial layers and inhibit mitral cells and tufted cells. Small distal processes make contacts with the exiting mitral cell axons." [BTO:0001327] +subset: pheno_slim +synonym: "accessory olfactory bulb granule cell layer" RELATED [BAMS:gr] +synonym: "granule cell layer" BROAD [BTO:0001327] +synonym: "granule layer of main olfactory bulb" RELATED [NLXANAT:20090404] +synonym: "main olfactory bulb granule cell layer" RELATED [BAMS:gr, BAMS:MOBgr] +synonym: "main olfactory bulb, granule layer" RELATED [BAMS:MOBgr] +synonym: "olfactory bulb main granule cell layer" EXACT [NLXANAT:20090404] +xref: BAMS:MOBgr +xref: BTO:0001327 +xref: DMBA:15909 +xref: EMAPA:35609 +xref: MA:0000971 +xref: MBA:220 +xref: neuronames:2714 +xref: NLXANAT:20090404 +is_a: UBERON:0004001 ! olfactory bulb layer + [Term] id: UBERON:0005381 name: dentate gyrus granule cell layer @@ -221070,7 +221944,7 @@ xref: neuronames:2122 is_a: UBERON:0002304 ! layer of dentate gyrus intersection_of: UBERON:0002304 ! layer of dentate gyrus intersection_of: immediately_deep_to UBERON:0004679 ! dentate gyrus molecular layer -relationship: composed_primarily_of CL:0000120 ! granule cell +relationship: composed_primarily_of CL:2000089 ! dentate gyrus granule cell relationship: immediately_deep_to UBERON:0004679 ! dentate gyrus molecular layer relationship: overlaps CL:0000118 ! basket cell @@ -233416,6 +234290,10 @@ is_a: UBERON:0008946 ! lung parenchyma intersection_of: UBERON:0000353 ! parenchyma intersection_of: part_of UBERON:0002299 ! alveolus of lung relationship: contributes_to_morphology_of UBERON:0006524 ! alveolar system +relationship: dc-contributor https://orcid.org/0000-0001-6677-8489 +relationship: has_part CL:0002062 ! type I pneumocyte +relationship: has_part CL:0002063 ! type II pneumocyte +relationship: has_part CL:0009089 ! lung pericyte relationship: part_of UBERON:0002299 ! alveolus of lung relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens @@ -233437,7 +234315,9 @@ xref: NCIT:C33426 xref: SCTID:361365004 xref: UMLS:C0225696 {source="ncithesaurus:Pulmonary_Acinus"} xref: Wikipedia:Acinus#The_Lungs -is_a: UBERON:0010368 {source="FMA"} ! pulmonary lobule +is_a: BFO:0000004 ! independent continuant +relationship: connected_to UBERON:0002187 ! terminal bronchiole +relationship: part_of UBERON:0010369 ! secondary pulmonary lobule relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] @@ -239149,12 +240029,23 @@ def: "The smallest anatomical unit of the lung, measuring 0.50 to 2.00 cm in dia synonym: "lobulus pulmonis" EXACT LATIN [FMA:75739, FMA:TA] xref: FMA:75739 xref: NCIT:C33428 -is_a: PR:000050567 ! protein-containing material entity is_a: UBERON:0009911 ! lobule intersection_of: UBERON:0009911 ! lobule intersection_of: part_of UBERON:0002048 ! lung -relationship: has_part UBERON:0002187 ! terminal bronchiole -relationship: part_of UBERON:0002048 ! lung +relationship: part_of UBERON:8600017 ! bronchopulmonary segment + +[Term] +id: UBERON:0010369 +name: secondary pulmonary lobule +namespace: uberon +def: "A unit of lung supplied by three to five terminal bronchioles and contained by fibrous septa." [PMID:3259815] +subset: human_reference_atlas +synonym: "lobulus pulmonis secondarius" EXACT LATIN [FMA:7414, FMA:TA] +xref: FMA:7414 +is_a: UBERON:0010368 {source="FMA"} ! pulmonary lobule +relationship: part_of UBERON:0008946 {source="FMA"} ! lung parenchyma +relationship: present_in_taxon NCBITaxon:9606 ! Homo sapiens +property_value: UBPROP:0000001 "a pyramidal mass of lung tissue with sides that are bounded by the incomplete interlobular connective tissue septa and with a base, which is 1-2 cm in diameter, which usually faces the pleural surface of the lung; lobules that occupy a more central position in the lung are not well defined and are considered to consist of three to five pulmonary acini with proximate terminal bronchioles." xsd:string {source="http://medical-dictionary.thefreedictionary.com/secondary+pulmonary+lobule"} [Term] id: UBERON:0010370 @@ -256473,6 +257364,20 @@ relationship: dc-contributor https://orcid.org/0000-0001-6677-8489 relationship: part_of UBERON:0011148 ! submucosal gland property_value: dcterms-date "2023-05-02T08:57:27Z" xsd:dateTime +[Term] +id: UBERON:8600017 +name: bronchopulmonary segment +namespace: uberon +def: "A discrete anatomical unit of the lung that is composed of a segmental bronchus and the lung tissue supplied by that bronchus. A bronchopulmonary segment exhibits a pyramidal shape, with its apex pointing towards the center of the lung and its base toward the pleural surface." [doi:10.1016/j.mpaic.2008.09.022, FMA:7312, PMID:18271171, PMID:33620799] +comment: A bronchopulmonary segment is surrounded by connective tissue septa, which are continuous with the pleural surface and prevent air collateralization between segments somewhat. In humans, the right lung has ten bronchopulmonary segments and eight or nine bronchopulmonary segments in the left lung. {xref="doi:10.1016/j.mpaic.2008.09.022", xref="PMID:18271171"} +synonym: "lung segment" EXACT [PMID:33620799] +is_a: UBERON:0000063 ! organ subunit +relationship: contributes_to_morphology_of UBERON:0000101 ! lobe of lung +relationship: dc-contributor https://orcid.org/0000-0001-6677-8489 +relationship: dc-contributor https://orcid.org/0000-0002-9185-3994 +relationship: part_of UBERON:0000101 ! lobe of lung +property_value: dcterms-date "2023-07-20T12:43:29Z" xsd:dateTime + [Term] id: http://purl.obolibrary.org/obo/D96882F1-8709-49AB-BCA9-772A67EA6C33 name: obsolete D96882F1-8709-49AB-BCA9-772A67EA6C33 @@ -256494,16 +257399,6 @@ id: CL:4030046 name: lacks_plasma_membrane_part expand_expression_to: "http://purl.obolibrary.org/obo/BFO_0000051 exactly 0 (http://purl.obolibrary.org/obo/GO_0005886 and http://purl.obolibrary.org/obo/BFO_0000051 some ?Y)" [] -[Typedef] -id: IAO:0000136 -name: is about -def: "A (currently) primitive relation that relates an information artifact to an entity." [] -property_value: editor_note "7/6/2009 Alan Ruttenberg. Following discussion with Jonathan Rees, and introduction of \"mentions\" relation. Weaken the is_about relationship to be primitive. \n\nWe will try to build it back up by elaborating the various subproperties that are more precisely defined.\n\nSome currently missing phenomena that should be considered \"about\" are predications - \"The only person who knows the answer is sitting beside me\" , Allegory, Satire, and other literary forms that can be topical without explicitly mentioning the topic." xsd:string -property_value: IAO:0000112 "This document is about information artifacts and their representations" xsd:string -property_value: IAO:0000114 IAO:0000125 -property_value: IAO:0000117 "person:Alan Ruttenberg" xsd:string -property_value: IAO:0000119 "Smith, Ceusters, Ruttenberg, 2000 years of philosophy" xsd:string - [Typedef] id: RO:0000052 name: characteristic of @@ -256618,21 +257513,6 @@ property_value: IAO:0000112 "this parent nucleus derives into this nucleus (nucl property_value: IAO:0000114 IAO:0000125 property_value: IAO:0000118 "derives_into" xsd:string -[Typedef] -id: RO:0001018 -name: contained in -subset: ro-eco -property_value: editor_note "Containment is location not involving parthood, and arises only where some immaterial continuant is involved." xsd:string -property_value: editor_note "Containment obtains in each case between material and immaterial continuants, for instance: lung contained_in thoracic cavity; bladder contained_in pelvic cavity. Hence containment is not a transitive relation. If c part_of c1 at t then we have also, by our definition and by the axioms of mereology applied to spatial regions, c located_in c1 at t. Thus, many examples of instance-level location relations for continuants are in fact cases of instance-level parthood. For material continuants location and parthood coincide. Containment is location not involving parthood, and arises only where some immaterial continuant is involved. To understand this relation, we first define overlap for continuants as follows: c1 overlap c2 at t =def for some c, c part_of c1 at t and c part_of c2 at t. The containment relation on the instance level can then be defined (see definition):" xsd:string -property_value: editor_note "Intended meaning:\ndomain: material entity\nrange: spatial region or site (immaterial continuant)\n " xsd:string -property_value: IAO:0000111 "contained in" xsd:string -property_value: IAO:0000118 "contained_in" xsd:string -property_value: RO:0001900 RO:0001901 -domain: BFO:0000040 ! material entity -range: BFO:0000004 ! independent continuant -holds_over_chain: located_in part_of -inverse_of: contains ! contains - [Typedef] id: RO:0002000 name: 2D boundary of @@ -257575,12 +258455,6 @@ property_value: IAO:0000119 http://purl.obolibrary.org/obo/ro/docs/causal-relati holds_over_chain: capable_of positively_regulates is_a: RO:0002596 ! capable of regulating -[Typedef] -id: RO:0002610 -name: correlated with -def: "A relationship that holds between two entities, where the entities exhibit a statistical dependence relationship. The entities may be statistical variables, or they may be other kinds of entities such as diseases, chemical entities or processes." [] -property_value: IAO:0000232 "Groups both positive and negative correlation" xsd:string - [Typedef] id: RO:0004031 name: enables subfunction @@ -257773,16 +258647,6 @@ property_value: IAO:0000232 "See github ticket https://github.com/oborel/obo-rel holds_over_chain: capable_of has_input creation_date: 2021-11-08T12:00:00Z -[Typedef] -id: RO:0017003 -name: positively correlated with -def: "A relation between entities in which one increases or decreases as the other does the same." [] -property_value: dc-contributor https://orcid.org/0000-0003-1909-9269 -property_value: IAO:0000118 "directly correlated with" xsd:string -is_reflexive: true -is_symmetric: true -is_a: RO:0002610 ! correlated with - [Typedef] id: acts_on_population_of name: acts on population of @@ -258095,11 +258959,12 @@ is_a: RO:0002323 ! mereotopologically related to [Typedef] id: contains name: contains +name: obsolete contains namespace: uberon -subset: ro-eco xref: RO:0001019 property_value: IAO:0000111 "contains" xsd:string -property_value: RO:0001900 RO:0001901 +property_value: seeAlso https://github.com/oborel/obo-relations/issues/693 +is_obsolete: true [Typedef] id: contains_process @@ -258375,13 +259240,7 @@ is_a: connected_to ! connected to id: editor_note name: editor note namespace: uberon -def: "An administrative note intended for its editor. It may not be included in the publication version of the ontology, so it should contain nothing necessary for end users to understand the ontology." [] xref: IAO:0000116 -property_value: IAO:0000111 "editor note" xsd:string -property_value: IAO:0000114 IAO:0000122 -property_value: IAO:0000117 "PERSON:Daniel Schober" xsd:string -property_value: IAO:0000119 "GROUP:OBI:" xsd:string -property_value: isDefinedBy http://purl.obolibrary.org/obo/iao.owl is_metadata_tag: true [Typedef] @@ -258700,12 +259559,11 @@ creation_date: 2017-05-24T09:31:01Z id: has_ontology_root_term name: has ontology root term name: preferred_root +namespace: external namespace: uberon -def: "Ontology annotation property. Relates an ontology to a term that is a designated root term of the ontology. Display tools like OLS can use terms annotated with this property as the starting point for rendering the ontology class hierarchy. There can be more than one root." [] xref: IAO:0000700 -property_value: IAO:0000111 "has ontology root term" xsd:string -property_value: IAO:0000117 "Nicolas Matentzoglu" xsd:string is_metadata_tag: true +is_class_level: true [Typedef] id: has_output @@ -258756,7 +259614,7 @@ namespace: external def: "a relation between a process and a continuant, in which the continuant is somehow involved in the process" [] xref: RO:0000057 property_value: editor_note "Has_participant is a primitive instance-level relation between a process, a continuant, and a time at which the continuant participates in some way in the process. The relation obtains, for example, when this particular process of oxygen exchange across this particular alveolar membrane has_participant this particular sample of hemoglobin at this particular time." xsd:string -property_value: http://purl.org/dc/elements/1.1/source "http://www.obofoundry.org/ro/#OBO_REL:has_participant" xsd:string +property_value: http://purl.org/dc/terms/source "http://www.obofoundry.org/ro/#OBO_REL:has_participant" xsd:string property_value: IAO:0000111 "has participant" xsd:string property_value: IAO:0000112 "this blood coagulation has participant this blood clot" xsd:string property_value: IAO:0000112 "this investigation has participant this investigator" xsd:string @@ -259153,7 +260011,7 @@ subset: http://purl.obolibrary.org/obo/valid_for_go_gp2term xref: RO:0001025 property_value: editor_note "Location as a relation between instances: The primitive instance-level relation c located_in r at t reflects the fact that each continuant is at any given time associated with exactly one spatial region, namely its exact location. Following we can use this relation to define a further instance-level location relation - not between a continuant and the region which it exactly occupies, but rather between one continuant and another. c is located in c1, in this sense, whenever the spatial region occupied by c is part_of the spatial region occupied by c1. Note that this relation comprehends both the relation of exact location between one continuant and another which obtains when r and r1 are identical (for example, when a portion of fluid exactly fills a cavity), as well as those sorts of inexact location relations which obtain, for example, between brain and head or between ovum and uterus" xsd:string property_value: editor_note "Most location relations will only hold at certain times, but this is difficult to specify in OWL. See http://purl.obolibrary.org/obo/ro/docs/temporal-semantics/" xsd:string -property_value: http://purl.org/dc/elements/1.1/source "http://www.obofoundry.org/ro/#OBO_REL:located_in" xsd:string +property_value: http://purl.org/dc/terms/source "http://www.obofoundry.org/ro/#OBO_REL:located_in" xsd:string property_value: IAO:0000111 "located in" xsd:string property_value: IAO:0000112 "my brain is located in my head" xsd:string property_value: IAO:0000112 "this rat is located in this cage" xsd:string @@ -259462,7 +260320,7 @@ def: "x is preceded by y if and only if the time point at which y ends is before subset: ro-eco xref: BFO:0000062 property_value: editor_note "An example is: translation preceded_by transcription; aging preceded_by development (not however death preceded_by aging). Where derives_from links classes of continuants, preceded_by links classes of processes. Clearly, however, these two relations are not independent of each other. Thus if cells of type C1 derive_from cells of type C, then any cell division involving an instance of C1 in a given lineage is preceded_by cellular processes involving an instance of C. The assertion P preceded_by P1 tells us something about Ps in general: that is, it tells us something about what happened earlier, given what we know about what happened later. Thus it does not provide information pointing in the opposite direction, concerning instances of P1 in general; that is, that each is such as to be succeeded by some instance of P. Note that an assertion to the effect that P preceded_by P1 is rather weak; it tells us little about the relations between the underlying instances in virtue of which the preceded_by relation obtains. Typically we will be interested in stronger relations, for example in the relation immediately_preceded_by, or in relations which combine preceded_by with a condition to the effect that the corresponding instances of P and P1 share participants, or that their participants are connected by relations of derivation, or (as a first step along the road to a treatment of causality) that the one process in some way affects (for example, initiates or regulates) the other." xsd:string -property_value: http://purl.org/dc/elements/1.1/source "http://www.obofoundry.org/ro/#OBO_REL:preceded_by" xsd:string +property_value: http://purl.org/dc/terms/source "http://www.obofoundry.org/ro/#OBO_REL:preceded_by" xsd:string property_value: IAO:0000111 "preceded by" xsd:string property_value: IAO:0000118 "is preceded by" xsd:string property_value: IAO:0000118 "preceded_by" xsd:string @@ -259997,14 +260855,7 @@ id: term_tracker_item name: term tracker item namespace: external namespace: uberon -def: "An IRI or similar locator for a request or discussion of an ontology term." [] -comment: The 'tracker item' can associate a tracker with a specific ontology term. xref: IAO:0000233 -property_value: IAO:0000111 "term tracker item" xsd:string -property_value: IAO:0000112 "the URI for an OBI Terms ticket at sourceforge, such as https://sourceforge.net/p/obi/obi-terms/772/" xsd:string -property_value: IAO:0000114 IAO:0000125 -property_value: IAO:0000117 "Person: Jie Zheng, Chris Stoeckert, Alan Ruttenberg" xsd:string -property_value: IAO:0000119 "Person: Jie Zheng, Chris Stoeckert, Alan Ruttenberg" xsd:string is_metadata_tag: true is_class_level: true diff --git a/patterns/definitions.owl b/patterns/definitions.owl index 5c99c468e..c9a38d90b 100644 --- a/patterns/definitions.owl +++ b/patterns/definitions.owl @@ -7,8 +7,8 @@ Prefix(rdfs:=) Ontology( - -Annotation(owl:versionInfo "2023-07-19") + +Annotation(owl:versionInfo "2023-08-23") diff --git a/src/ontology/diffs/cl-diff.md b/src/ontology/diffs/cl-diff.md index e7c0370d5..a7a6c9a52 100644 --- a/src/ontology/diffs/cl-diff.md +++ b/src/ontology/diffs/cl-diff.md @@ -2,12 +2,12 @@ ## Left - Ontology IRI: `http://purl.obolibrary.org/obo/cl.owl` -- Version IRI: `http://purl.obolibrary.org/obo/cl/releases/2023-06-22/cl.owl` +- Version IRI: `http://purl.obolibrary.org/obo/cl/releases/2023-07-20/cl.owl` - Loaded from: `http://purl.obolibrary.org/obo/cl.owl` ## Right - Ontology IRI: `http://purl.obolibrary.org/obo/cl.owl` -- Version IRI: `http://purl.obolibrary.org/obo/cl/releases/2023-07-20/cl.owl` +- Version IRI: `http://purl.obolibrary.org/obo/cl/releases/2023-08-24/cl.owl` - Loaded from: `file:/work/src/ontology/../../cl.owl` ### Ontology imports @@ -16,7734 +16,14132 @@ ### Ontology annotations #### Removed -- [versionInfo](http://www.w3.org/2002/07/owl#versionInfo) "2023-06-22" +- [versionInfo](http://www.w3.org/2002/07/owl#versionInfo) "2023-07-20" #### Added -- [versionInfo](http://www.w3.org/2002/07/owl#versionInfo) "2023-07-20" +- [versionInfo](http://www.w3.org/2002/07/owl#versionInfo) "2023-08-24" -### 1st arch maxillary ectoderm `http://purl.obolibrary.org/obo/UBERON_0012313` +### AB broad diffuse-1 amacrine cell `http://purl.obolibrary.org/obo/CL_0004235` #### Removed -- [1st arch maxillary ectoderm](http://purl.obolibrary.org/obo/UBERON_0012313) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [AB broad diffuse-1 amacrine cell](http://purl.obolibrary.org/obo/CL_0004235) SubClassOf [retina horizontal cell](http://purl.obolibrary.org/obo/CL_0000745) -### ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 `http://purl.obolibrary.org/obo/PR_000001408` +### AB broad diffuse-2 amacrine cell `http://purl.obolibrary.org/obo/CL_0004236` +#### Removed +- [AB broad diffuse-2 amacrine cell](http://purl.obolibrary.org/obo/CL_0004236) SubClassOf [retina horizontal cell](http://purl.obolibrary.org/obo/CL_0000745) -#### Added -- [ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1](http://purl.obolibrary.org/obo/PR_000001408) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (human)](http://purl.obolibrary.org/obo/PR_P28907) -### B-cell lymphoma 6 protein `http://purl.obolibrary.org/obo/PR_000003450` +### AB diffuse-1 amacrine cell `http://purl.obolibrary.org/obo/CL_0004223` +#### Removed +- [AB diffuse-1 amacrine cell](http://purl.obolibrary.org/obo/CL_0004223) SubClassOf [retina horizontal cell](http://purl.obolibrary.org/obo/CL_0000745) #### Added -- [B-cell lymphoma 6 protein](http://purl.obolibrary.org/obo/PR_000003450) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [B-cell lymphoma 6 protein (human)](http://purl.obolibrary.org/obo/PR_P41182) +- [AB diffuse-1 amacrine cell](http://purl.obolibrary.org/obo/CL_0004223) SubClassOf [amacrine cell](http://purl.obolibrary.org/obo/CL_0000561) -### B-cell receptor CD22 `http://purl.obolibrary.org/obo/PR_000001288` +### ATP hydrolysis activity `http://purl.obolibrary.org/obo/GO_0016887` +#### Removed +- [ATP hydrolysis activity](http://purl.obolibrary.org/obo/GO_0016887) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-6811422" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "NSF ATPase activity dissociates cis-SNARE at the ER" -#### Added -- [B-cell receptor CD22](http://purl.obolibrary.org/obo/PR_000001288) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [B-cell receptor CD22 (human)](http://purl.obolibrary.org/obo/PR_P20273) +- [ATP hydrolysis activity](http://purl.obolibrary.org/obo/GO_0016887) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-8939203" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "HSP90-dependent ATP hydrolysis promotes release of ESR:ESTG from chaperone complex" +- [ATP hydrolysis activity](http://purl.obolibrary.org/obo/GO_0016887) [term tracker item](http://purl.obolibrary.org/obo/IAO_0000233) "https://github.com/geneontology/go-ontology/issues/19078"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI) -### BFO_0000001 `http://purl.obolibrary.org/obo/BFO_0000001` +- [ATP hydrolysis activity](http://purl.obolibrary.org/obo/GO_0016887) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-8868658" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "HSPA8-mediated ATP hydrolysis promotes vesicle uncoating" -#### Added -- Class: [BFO_0000001](http://purl.obolibrary.org/obo/BFO_0000001) +- [ATP hydrolysis activity](http://purl.obolibrary.org/obo/GO_0016887) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-9609860" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Tail-anchored protein:SGTA:BAG6:GET4:UBL4A:ASNA1:ATP dissociates and ASNA1 hydrolyzes ATP yielding Tail-anchored protein:ASNA1:ADP" +- [ATP hydrolysis activity](http://purl.obolibrary.org/obo/GO_0016887) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-6809015" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "NSF ATPase activity dissociates cis-SNARE at cis-Golgi" -### C-C chemokine receptor type 1 `http://purl.obolibrary.org/obo/PR_000001254` +- [ATP hydrolysis activity](http://purl.obolibrary.org/obo/GO_0016887) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "adenosinetriphosphatase activity" -#### Added -- [C-C chemokine receptor type 1](http://purl.obolibrary.org/obo/PR_000001254) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [C-C chemokine receptor type 1 (human)](http://purl.obolibrary.org/obo/PR_P32246) +- [ATP hydrolysis activity](http://purl.obolibrary.org/obo/GO_0016887) [has_alternative_id](http://www.geneontology.org/formats/oboInOwl#hasAlternativeId) "GO:0004002" +- [ATP hydrolysis activity](http://purl.obolibrary.org/obo/GO_0016887) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-6814670" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "ATP hydrolysis by RHOBTB3 promotes PLIN3 dissociation" -### C-C chemokine receptor type 2 `http://purl.obolibrary.org/obo/PR_000001199` +- [ATP hydrolysis activity](http://purl.obolibrary.org/obo/GO_0016887) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "molecular_function" -#### Added -- [C-C chemokine receptor type 2](http://purl.obolibrary.org/obo/PR_000001199) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [C-C chemokine receptor type 2 (human)](http://purl.obolibrary.org/obo/PR_P41597) +- [ATP hydrolysis activity](http://purl.obolibrary.org/obo/GO_0016887) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-9706399" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "RHOBTB3 hydrolyzes ATP" +- [ATP hydrolysis activity](http://purl.obolibrary.org/obo/GO_0016887) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-5654989" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA" -### C-C chemokine receptor type 3 `http://purl.obolibrary.org/obo/PR_000001255` +- [ATP hydrolysis activity](http://purl.obolibrary.org/obo/GO_0016887) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "ATP monophosphatase activity" -#### Added -- [C-C chemokine receptor type 3](http://purl.obolibrary.org/obo/PR_000001255) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [C-C chemokine receptor type 3 (human)](http://purl.obolibrary.org/obo/PR_P51677) +- [ATP hydrolysis activity](http://purl.obolibrary.org/obo/GO_0016887) [term tracker item](http://purl.obolibrary.org/obo/IAO_0000233) "https://github.com/geneontology/go-ontology/issues/20498"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI) +- [ATP hydrolysis activity](http://purl.obolibrary.org/obo/GO_0016887) [label](http://www.w3.org/2000/01/rdf-schema#label) "ATP hydrolysis activity" -### C-C chemokine receptor type 4 `http://purl.obolibrary.org/obo/PR_000001200` +- [ATP hydrolysis activity](http://purl.obolibrary.org/obo/GO_0016887) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-3371422" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "ATP hydrolysis by HSP70" -#### Added -- [C-C chemokine receptor type 4](http://purl.obolibrary.org/obo/PR_000001200) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [C-C chemokine receptor type 4 (human)](http://purl.obolibrary.org/obo/PR_P51679) +- [ATP hydrolysis activity](http://purl.obolibrary.org/obo/GO_0016887) [term tracker item](http://purl.obolibrary.org/obo/IAO_0000233) "https://github.com/geneontology/go-ontology/issues/21612"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI) +- [ATP hydrolysis activity](http://purl.obolibrary.org/obo/GO_0016887) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-6814678" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "ATP hydrolysis by NSF disassembles the cis-SNARE at the TGN" -### C-C chemokine receptor type 5 `http://purl.obolibrary.org/obo/PR_000001201` +- [ATP hydrolysis activity](http://purl.obolibrary.org/obo/GO_0016887) [term tracker item](http://purl.obolibrary.org/obo/IAO_0000233) "https://github.com/geneontology/go-ontology/issues/22371"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI) -#### Added -- [C-C chemokine receptor type 5](http://purl.obolibrary.org/obo/PR_000001201) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [C-C chemokine receptor type 5 (human)](http://purl.obolibrary.org/obo/PR_P51681) +- [ATP hydrolysis activity](http://purl.obolibrary.org/obo/GO_0016887) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-8847638" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "ATP hydrolysis by NSF disassembles the cis-SNARE at the Golgi membrane" +- [ATP hydrolysis activity](http://purl.obolibrary.org/obo/GO_0016887) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "Note that this term is meant to specifically represent the ATPase activity of proteins using ATP as a source of energy to drive a reaction. If possible, gene products should also be annotated to a child of 'ATP-dependent activity ; GO:0140657', to capture their overall function." -### C-C chemokine receptor type 6 `http://purl.obolibrary.org/obo/PR_000001202` +- [ATP hydrolysis activity](http://purl.obolibrary.org/obo/GO_0016887) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-9038161" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Progesterone stimulation promotes PGR:P4 binding to ESR1:ESTG" -#### Added -- [C-C chemokine receptor type 6](http://purl.obolibrary.org/obo/PR_000001202) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [C-C chemokine receptor type 6 (human)](http://purl.obolibrary.org/obo/PR_P51684) +- [ATP hydrolysis activity](http://purl.obolibrary.org/obo/GO_0016887) [has_alternative_id](http://www.geneontology.org/formats/oboInOwl#hasAlternativeId) "GO:0042623" +- [ATP hydrolysis activity](http://purl.obolibrary.org/obo/GO_0016887) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-9749350" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "ATP-dependent release of CDT1 from the OCCM complex" -### C-C chemokine receptor type 7 `http://purl.obolibrary.org/obo/PR_000001203` +- [ATP hydrolysis activity](http://purl.obolibrary.org/obo/GO_0016887) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "RHEA:13065" -#### Added -- [C-C chemokine receptor type 7](http://purl.obolibrary.org/obo/PR_000001203) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [C-C chemokine receptor type 7 (human)](http://purl.obolibrary.org/obo/PR_P32248) +- [ATP hydrolysis activity](http://purl.obolibrary.org/obo/GO_0016887) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-5694425" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "NSF ATPase activity dissociates cis-SNARE" +- [ATP hydrolysis activity](http://purl.obolibrary.org/obo/GO_0016887) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-917693" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "ESCRT Disassembly" -### C-C motif chemokine 3 `http://purl.obolibrary.org/obo/PR_000002123` +- [ATP hydrolysis activity](http://purl.obolibrary.org/obo/GO_0016887) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-5618093" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "ATP hydrolysis by HSP90" -#### Added -- [C-C motif chemokine 3](http://purl.obolibrary.org/obo/PR_000002123) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [C-C motif chemokine 3 (human)](http://purl.obolibrary.org/obo/PR_P10147) +- [ATP hydrolysis activity](http://purl.obolibrary.org/obo/GO_0016887) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-6814683" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "NSF-dependent ATP hydrolysis disassembles the cis-SNARE at the TGN" +- [ATP hydrolysis activity](http://purl.obolibrary.org/obo/GO_0016887) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-9668415" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "VPS4 mediates disassembly of ESCRTIII subunits to promote sealing of holes in the nuclear envelope" -### C-X-C chemokine receptor type 1 `http://purl.obolibrary.org/obo/PR_000001256` +- [ATP hydrolysis activity](http://purl.obolibrary.org/obo/GO_0016887) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-159101" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B)" -#### Added -- [C-X-C chemokine receptor type 1](http://purl.obolibrary.org/obo/PR_000001256) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [C-X-C chemokine receptor type 1 (human)](http://purl.obolibrary.org/obo/PR_P25024) +- [ATP hydrolysis activity](http://purl.obolibrary.org/obo/GO_0016887) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "ATP phosphohydrolase activity" +- [ATP hydrolysis activity](http://purl.obolibrary.org/obo/GO_0016887) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "adenosine triphosphatase activity" -### C-X-C chemokine receptor type 2 `http://purl.obolibrary.org/obo/PR_000001257` +- [ATP hydrolysis activity](http://purl.obolibrary.org/obo/GO_0016887) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "adenosine 5'-triphosphatase activity" -#### Added -- [C-X-C chemokine receptor type 2](http://purl.obolibrary.org/obo/PR_000001257) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [C-X-C chemokine receptor type 2 (human)](http://purl.obolibrary.org/obo/PR_P25025) +- [ATP hydrolysis activity](http://purl.obolibrary.org/obo/GO_0016887) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "RHEA:13065" +- [ATP hydrolysis activity](http://purl.obolibrary.org/obo/GO_0016887) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "ATP hydrolase activity" -### C-X-C chemokine receptor type 3 `http://purl.obolibrary.org/obo/PR_000001207` +- [ATP hydrolysis activity](http://purl.obolibrary.org/obo/GO_0016887) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0016887" -#### Added -- [C-X-C chemokine receptor type 3](http://purl.obolibrary.org/obo/PR_000001207) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [C-X-C chemokine receptor type 3 (human)](http://purl.obolibrary.org/obo/PR_P49682) +- [ATP hydrolysis activity](http://purl.obolibrary.org/obo/GO_0016887) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-416985" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Trafficking of GluR2-containing AMPA receptors to synapse" +- Class: [ATP hydrolysis activity](http://purl.obolibrary.org/obo/GO_0016887) -### C-X-C chemokine receptor type 4 `http://purl.obolibrary.org/obo/PR_000001208` +- [ATP hydrolysis activity](http://purl.obolibrary.org/obo/GO_0016887) SubClassOf [has participant](http://purl.obolibrary.org/obo/RO_0000057) some [CHEBI_30616](http://purl.obolibrary.org/obo/CHEBI_30616) -#### Added -- [C-X-C chemokine receptor type 4](http://purl.obolibrary.org/obo/PR_000001208) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [C-X-C chemokine receptor type 4 (human)](http://purl.obolibrary.org/obo/PR_P61073) +- [ATP hydrolysis activity](http://purl.obolibrary.org/obo/GO_0016887) SubClassOf [ribonucleoside triphosphate phosphatase activity](http://purl.obolibrary.org/obo/GO_0017111) +- [ATP hydrolysis activity](http://purl.obolibrary.org/obo/GO_0016887) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [ATP-dependent activity](http://purl.obolibrary.org/obo/GO_0140657) -### C-X-C chemokine receptor type 5 `http://purl.obolibrary.org/obo/PR_000001209` +- [ATP hydrolysis activity](http://purl.obolibrary.org/obo/GO_0016887) SubClassOf [has participant](http://purl.obolibrary.org/obo/RO_0000057) some [CHEBI_456216](http://purl.obolibrary.org/obo/CHEBI_456216) -#### Added -- [C-X-C chemokine receptor type 5](http://purl.obolibrary.org/obo/PR_000001209) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [C-X-C chemokine receptor type 5 (human)](http://purl.obolibrary.org/obo/PR_P32302) -### C-type lectin domain family 4 member C `http://purl.obolibrary.org/obo/PR_000001292` +### ATP-dependent activity `http://purl.obolibrary.org/obo/GO_0140657` +#### Removed +- [ATP-dependent activity](http://purl.obolibrary.org/obo/GO_0140657) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [goslim_yeast](http://purl.obolibrary.org/obo/go#goslim_yeast) -#### Added -- [C-type lectin domain family 4 member C](http://purl.obolibrary.org/obo/PR_000001292) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [C-type lectin domain family 4 member C (human)](http://purl.obolibrary.org/obo/PR_Q8WTT0) +- [ATP-dependent activity](http://purl.obolibrary.org/obo/GO_0140657) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "ATPase activity, coupled" +- [ATP-dependent activity](http://purl.obolibrary.org/obo/GO_0140657) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A molecular function characterized by the coupling of ATP hydrolysis to other steps of a reaction mechanism to make the reaction energetically favorable, for example to catalyze a reaction or drive transport against a concentration gradient." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:24878343" -### C-type lectin domain family 4 member K `http://purl.obolibrary.org/obo/PR_000001293` + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:25750732" -#### Added -- [C-type lectin domain family 4 member K](http://purl.obolibrary.org/obo/PR_000001293) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [C-type lectin domain family 4 member K (human)](http://purl.obolibrary.org/obo/PR_Q9UJ71) + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:33873056" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:32933017" -### C-type lectin domain family 6 member A `http://purl.obolibrary.org/obo/PR_000001806` + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:33988324" -#### Added -- [C-type lectin domain family 6 member A](http://purl.obolibrary.org/obo/PR_000001806) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [C-type lectin domain family 6 member A (human)](http://purl.obolibrary.org/obo/PR_Q6EIG7) + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:33818025" +- [ATP-dependent activity](http://purl.obolibrary.org/obo/GO_0140657) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "ATPase activity" -### C-type lectin domain family 7 member A `http://purl.obolibrary.org/obo/PR_000001807` +- [ATP-dependent activity](http://purl.obolibrary.org/obo/GO_0140657) [term tracker item](http://purl.obolibrary.org/obo/IAO_0000233) "https://github.com/geneontology/go-ontology/issues/22371"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI) -#### Added -- [C-type lectin domain family 7 member A](http://purl.obolibrary.org/obo/PR_000001807) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [C-type lectin domain family 7 member A (human)](http://purl.obolibrary.org/obo/PR_Q9BXN2) +- [ATP-dependent activity](http://purl.obolibrary.org/obo/GO_0140657) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [goslim_generic](http://purl.obolibrary.org/obo/go#goslim_generic) +- [ATP-dependent activity](http://purl.obolibrary.org/obo/GO_0140657) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate) -### CCAAT/enhancer-binding protein alpha `http://purl.obolibrary.org/obo/PR_000005307` +- [ATP-dependent activity](http://purl.obolibrary.org/obo/GO_0140657) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0140657" -#### Added -- [CCAAT/enhancer-binding protein alpha](http://purl.obolibrary.org/obo/PR_000005307) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [CCAAT/enhancer-binding protein alpha (human)](http://purl.obolibrary.org/obo/PR_P49715) +- [ATP-dependent activity](http://purl.obolibrary.org/obo/GO_0140657) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "ATPase-dependent activity" +- [ATP-dependent activity](http://purl.obolibrary.org/obo/GO_0140657) [term tracker item](http://purl.obolibrary.org/obo/IAO_0000233) "https://github.com/geneontology/go-ontology/issues/21612"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI) -### CCAAT/enhancer-binding protein epsilon `http://purl.obolibrary.org/obo/PR_000005310` +- [ATP-dependent activity](http://purl.obolibrary.org/obo/GO_0140657) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "pg" -#### Added -- [CCAAT/enhancer-binding protein epsilon](http://purl.obolibrary.org/obo/PR_000005310) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [CCAAT/enhancer-binding protein epsilon (human)](http://purl.obolibrary.org/obo/PR_Q15744) +- [ATP-dependent activity](http://purl.obolibrary.org/obo/GO_0140657) [label](http://www.w3.org/2000/01/rdf-schema#label) "ATP-dependent activity" +- [ATP-dependent activity](http://purl.obolibrary.org/obo/GO_0140657) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [goslim_drosophila](http://purl.obolibrary.org/obo/go#goslim_drosophila) -### CD115-positive monocyte `http://purl.obolibrary.org/obo/CL_0001022` -#### Removed -- [CD115-positive monocyte](http://purl.obolibrary.org/obo/CL_0001022) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [ATP-dependent activity](http://purl.obolibrary.org/obo/GO_0140657) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "Note that this term represents a grouping class that includes all proteins that use ATP hydrolysis to drive a reaction; it is not meant to capture the ATP hydrolysis reaction itself. To annotate ATP hydrolysis, please use 'ATP hydrolysis activity ; GO:0016887'." +- [ATP-dependent activity](http://purl.obolibrary.org/obo/GO_0140657) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "molecular_function" +- [ATP-dependent activity](http://purl.obolibrary.org/obo/GO_0140657) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "ATP hydrolysis-dependent activity" -### CD11c-low plasmacytoid dendritic cell `http://purl.obolibrary.org/obo/CL_0000989` -#### Removed -- [CD11c-low plasmacytoid dendritic cell](http://purl.obolibrary.org/obo/CL_0000989) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [ATP-dependent activity](http://purl.obolibrary.org/obo/GO_0140657) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [prokaryote_subset](http://purl.obolibrary.org/obo/go#prokaryote_subset) +- [ATP-dependent activity](http://purl.obolibrary.org/obo/GO_0140657) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2021-06-15T07:35:06Z" +- [ATP-dependent activity](http://purl.obolibrary.org/obo/GO_0140657) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [goslim_chembl](http://purl.obolibrary.org/obo/go#goslim_chembl) -### CD11c-negative plasmacytoid dendritic cell `http://purl.obolibrary.org/obo/CL_0000991` -#### Removed -- [CD11c-negative plasmacytoid dendritic cell](http://purl.obolibrary.org/obo/CL_0000991) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- Class: [ATP-dependent activity](http://purl.obolibrary.org/obo/GO_0140657) +- [ATP-dependent activity](http://purl.obolibrary.org/obo/GO_0140657) EquivalentTo [molecular_function](http://purl.obolibrary.org/obo/GO_0003674) and ([has part](http://purl.obolibrary.org/obo/BFO_0000051) some [ATP hydrolysis activity](http://purl.obolibrary.org/obo/GO_0016887)) +- [ATP-dependent activity](http://purl.obolibrary.org/obo/GO_0140657) SubClassOf [molecular_function](http://purl.obolibrary.org/obo/GO_0003674) -### CD14-positive monocyte `http://purl.obolibrary.org/obo/CL_0001054` -#### Removed -- [CD14-positive monocyte](http://purl.obolibrary.org/obo/CL_0001054) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [ATP-dependent activity](http://purl.obolibrary.org/obo/GO_0140657) SubClassOf [has part](http://purl.obolibrary.org/obo/BFO_0000051) some [ATP hydrolysis activity](http://purl.obolibrary.org/obo/GO_0016887) -### CD16-negative, CD56-bright natural killer cell, human `http://purl.obolibrary.org/obo/CL_0000938` +### ATP-dependent activity, acting on DNA `http://purl.obolibrary.org/obo/GO_0008094` #### Removed -- [CD16-negative, CD56-bright natural killer cell, human](http://purl.obolibrary.org/obo/CL_0000938) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [ATP-dependent activity, acting on DNA](http://purl.obolibrary.org/obo/GO_0008094) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0008094" +- [ATP-dependent activity, acting on DNA](http://purl.obolibrary.org/obo/GO_0008094) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "DNA-dependent adenosinetriphosphatase activity" +- [ATP-dependent activity, acting on DNA](http://purl.obolibrary.org/obo/GO_0008094) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "molecular_function" -### CD16-positive, CD56-dim natural killer cell, human `http://purl.obolibrary.org/obo/CL_0000939` -#### Removed -- [CD16-positive, CD56-dim natural killer cell, human](http://purl.obolibrary.org/obo/CL_0000939) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) - +- [ATP-dependent activity, acting on DNA](http://purl.obolibrary.org/obo/GO_0008094) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "adenosinetriphosphatase (DNA-dependent)" +- [ATP-dependent activity, acting on DNA](http://purl.obolibrary.org/obo/GO_0008094) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "DNA dependent ATPase activity" -### CD25+ mast cell `http://purl.obolibrary.org/obo/CL_0011023` -#### Removed -- [CD25+ mast cell](http://purl.obolibrary.org/obo/CL_0011023) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [ATP-dependent activity, acting on DNA](http://purl.obolibrary.org/obo/GO_0008094) [term tracker item](http://purl.obolibrary.org/obo/IAO_0000233) "https://github.com/geneontology/go-ontology/issues/21612"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI) +- [ATP-dependent activity, acting on DNA](http://purl.obolibrary.org/obo/GO_0008094) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Catalytic activity that acts to modify DNA, driven by ATP hydrolysis." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:pdt" +- [ATP-dependent activity, acting on DNA](http://purl.obolibrary.org/obo/GO_0008094) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "DNA-dependent ATPase activity" -### CD27-high, CD11b-high natural killer cell, mouse `http://purl.obolibrary.org/obo/CL_0002347` -#### Removed -- [CD27-high, CD11b-high natural killer cell, mouse](http://purl.obolibrary.org/obo/CL_0002347) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [ATP-dependent activity, acting on DNA](http://purl.obolibrary.org/obo/GO_0008094) [label](http://www.w3.org/2000/01/rdf-schema#label) "ATP-dependent activity, acting on DNA" +- [ATP-dependent activity, acting on DNA](http://purl.obolibrary.org/obo/GO_0008094) [has_alternative_id](http://www.geneontology.org/formats/oboInOwl#hasAlternativeId) "GO:0004011" +- [ATP-dependent activity, acting on DNA](http://purl.obolibrary.org/obo/GO_0008094) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "ATPase, acting on DNA" -### CD27-high, CD11b-low natural killer cell, mouse `http://purl.obolibrary.org/obo/CL_0002349` -#### Removed -- [CD27-high, CD11b-low natural killer cell, mouse](http://purl.obolibrary.org/obo/CL_0002349) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [ATP-dependent activity, acting on DNA](http://purl.obolibrary.org/obo/GO_0008094) [term tracker item](http://purl.obolibrary.org/obo/IAO_0000233) "https://github.com/geneontology/go-ontology/issues/21775"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI) +- [ATP-dependent activity, acting on DNA](http://purl.obolibrary.org/obo/GO_0008094) [term tracker item](http://purl.obolibrary.org/obo/IAO_0000233) "https://github.com/geneontology/go-ontology/issues/20876"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI) +- [ATP-dependent activity, acting on DNA](http://purl.obolibrary.org/obo/GO_0008094) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "ATPase activity, acting on DNA" -### CD27-low, CD11b-high natural killer cell, mouse `http://purl.obolibrary.org/obo/CL_0002348` -#### Removed -- [CD27-low, CD11b-high natural killer cell, mouse](http://purl.obolibrary.org/obo/CL_0002348) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- Class: [ATP-dependent activity, acting on DNA](http://purl.obolibrary.org/obo/GO_0008094) +- [ATP-dependent activity, acting on DNA](http://purl.obolibrary.org/obo/GO_0008094) EquivalentTo [catalytic activity, acting on DNA](http://purl.obolibrary.org/obo/GO_0140097) and ([has part](http://purl.obolibrary.org/obo/BFO_0000051) some [ATP hydrolysis activity](http://purl.obolibrary.org/obo/GO_0016887)) +- [ATP-dependent activity, acting on DNA](http://purl.obolibrary.org/obo/GO_0008094) SubClassOf [ATP-dependent activity](http://purl.obolibrary.org/obo/GO_0140657) -### CD27-low, CD11b-low immature natural killer cell, mouse `http://purl.obolibrary.org/obo/CL_0002345` -#### Removed -- [CD27-low, CD11b-low immature natural killer cell, mouse](http://purl.obolibrary.org/obo/CL_0002345) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [ATP-dependent activity, acting on DNA](http://purl.obolibrary.org/obo/GO_0008094) SubClassOf [catalytic activity, acting on DNA](http://purl.obolibrary.org/obo/GO_0140097) -### CD34-negative, CD117-positive innate lymphoid cell, human `http://purl.obolibrary.org/obo/CL_0001072` +### ATP-dependent activity, acting on RNA `http://purl.obolibrary.org/obo/GO_0008186` #### Removed -- [CD34-negative, CD117-positive innate lymphoid cell, human](http://purl.obolibrary.org/obo/CL_0001072) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) - +- [ATP-dependent activity, acting on RNA](http://purl.obolibrary.org/obo/GO_0008186) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-9772351" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Disassembly of the Intron Lariat Spliceosome (new)" +- [ATP-dependent activity, acting on RNA](http://purl.obolibrary.org/obo/GO_0008186) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "ATPase activity, acting on RNA" -### CD34-negative, CD41-positive, CD42-positive megakaryocyte cell `http://purl.obolibrary.org/obo/CL_0002026` -#### Removed -- [CD34-negative, CD41-positive, CD42-positive megakaryocyte cell](http://purl.obolibrary.org/obo/CL_0002026) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) - +- [ATP-dependent activity, acting on RNA](http://purl.obolibrary.org/obo/GO_0008186) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of RNA, and it drives another reaction." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:jl" +- [ATP-dependent activity, acting on RNA](http://purl.obolibrary.org/obo/GO_0008186) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-9770847" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Spliceosomal P complex dissociates yielding the intron-containing complex (ILS) and the spliced mRNP (new)" -### CD34-positive, CD38-negative hematopoietic stem cell `http://purl.obolibrary.org/obo/CL_0001024` -#### Removed -- [CD34-positive, CD38-negative hematopoietic stem cell](http://purl.obolibrary.org/obo/CL_0001024) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [ATP-dependent activity, acting on RNA](http://purl.obolibrary.org/obo/GO_0008186) [label](http://www.w3.org/2000/01/rdf-schema#label) "ATP-dependent activity, acting on RNA" +- [ATP-dependent activity, acting on RNA](http://purl.obolibrary.org/obo/GO_0008186) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "RNA-dependent ATPase activity" +- [ATP-dependent activity, acting on RNA](http://purl.obolibrary.org/obo/GO_0008186) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "ATPase, acting on RNA" -### CD34-positive, CD38-positive common lymphoid progenitor `http://purl.obolibrary.org/obo/CL_0001021` -#### Removed -- [CD34-positive, CD38-positive common lymphoid progenitor](http://purl.obolibrary.org/obo/CL_0001021) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [ATP-dependent activity, acting on RNA](http://purl.obolibrary.org/obo/GO_0008186) [term tracker item](http://purl.obolibrary.org/obo/IAO_0000233) "https://github.com/geneontology/go-ontology/issues/20876"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI) +- [ATP-dependent activity, acting on RNA](http://purl.obolibrary.org/obo/GO_0008186) [has_alternative_id](http://www.geneontology.org/formats/oboInOwl#hasAlternativeId) "GO:0004010" +- [ATP-dependent activity, acting on RNA](http://purl.obolibrary.org/obo/GO_0008186) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "RNA-dependent adenosinetriphosphatase activity" -### CD34-positive, CD38-positive megakaryocyte erythroid progenitor cell `http://purl.obolibrary.org/obo/CL_0002005` -#### Removed -- [CD34-positive, CD38-positive megakaryocyte erythroid progenitor cell](http://purl.obolibrary.org/obo/CL_0002005) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [ATP-dependent activity, acting on RNA](http://purl.obolibrary.org/obo/GO_0008186) [term tracker item](http://purl.obolibrary.org/obo/IAO_0000233) "https://github.com/geneontology/go-ontology/issues/21775"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI) +- [ATP-dependent activity, acting on RNA](http://purl.obolibrary.org/obo/GO_0008186) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0008186" +- [ATP-dependent activity, acting on RNA](http://purl.obolibrary.org/obo/GO_0008186) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "molecular_function" -### CD34-positive, CD41-positive, CD42-negative megakaryocyte progenitor cell `http://purl.obolibrary.org/obo/CL_0002025` -#### Removed -- [CD34-positive, CD41-positive, CD42-negative megakaryocyte progenitor cell](http://purl.obolibrary.org/obo/CL_0002025) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- Class: [ATP-dependent activity, acting on RNA](http://purl.obolibrary.org/obo/GO_0008186) +- [ATP-dependent activity, acting on RNA](http://purl.obolibrary.org/obo/GO_0008186) EquivalentTo [ATP-dependent activity](http://purl.obolibrary.org/obo/GO_0140657) and ([has input](http://purl.obolibrary.org/obo/RO_0002233) some [CHEBI_33697](http://purl.obolibrary.org/obo/CHEBI_33697)) +- [ATP-dependent activity, acting on RNA](http://purl.obolibrary.org/obo/GO_0008186) SubClassOf [ATP-dependent activity](http://purl.obolibrary.org/obo/GO_0140657) -### CD34-positive, CD41-positive, CD42-positive megakaryocyte progenitor cell `http://purl.obolibrary.org/obo/CL_0002023` -#### Removed -- [CD34-positive, CD41-positive, CD42-positive megakaryocyte progenitor cell](http://purl.obolibrary.org/obo/CL_0002023) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [ATP-dependent activity, acting on RNA](http://purl.obolibrary.org/obo/GO_0008186) SubClassOf [has input](http://purl.obolibrary.org/obo/RO_0002233) some [CHEBI_33697](http://purl.obolibrary.org/obo/CHEBI_33697) -### CD34-positive, CD56-positive, CD117-positive common innate lymphoid precursor, human `http://purl.obolibrary.org/obo/CL_0001074` +### ATPase complex `http://purl.obolibrary.org/obo/GO_1904949` #### Removed -- [CD34-positive, CD56-positive, CD117-positive common innate lymphoid precursor, human](http://purl.obolibrary.org/obo/CL_0001074) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) - +- [ATPase complex](http://purl.obolibrary.org/obo/GO_1904949) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "VPS4 complex" +- [ATPase complex](http://purl.obolibrary.org/obo/GO_1904949) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2016-02-04T22:13:32Z" -### CD56-negative, CD161-positive immature natural killer cell, human `http://purl.obolibrary.org/obo/CL_0002344` -#### Removed -- [CD56-negative, CD161-positive immature natural killer cell, human](http://purl.obolibrary.org/obo/CL_0002344) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [ATPase complex](http://purl.obolibrary.org/obo/GO_1904949) [label](http://www.w3.org/2000/01/rdf-schema#label) "ATPase complex" +- [ATPase complex](http://purl.obolibrary.org/obo/GO_1904949) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:1904949" +- [ATPase complex](http://purl.obolibrary.org/obo/GO_1904949) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "bhm" -### CD56-positive, CD161-positive immature natural killer cell, human `http://purl.obolibrary.org/obo/CL_0002338` -#### Removed -- [CD56-positive, CD161-positive immature natural killer cell, human](http://purl.obolibrary.org/obo/CL_0002338) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [ATPase complex](http://purl.obolibrary.org/obo/GO_1904949) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A protein complex which is capable of ATPase activity." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:9606181" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:bhm" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" -### CD7-negative lymphoid progenitor cell `http://purl.obolibrary.org/obo/CL_0001027` -#### Removed -- [CD7-negative lymphoid progenitor cell](http://purl.obolibrary.org/obo/CL_0001027) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GO_REF:0000088" +- [ATPase complex](http://purl.obolibrary.org/obo/GO_1904949) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "cellular_component" +- [ATPase complex](http://purl.obolibrary.org/obo/GO_1904949) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "An example of this is VPS4 in Saccharomyces cerevisiae (UniProt ID P52917) in PMID:9606181 (inferred from direct assay)." -### CD7-positive lymphoid progenitor cell `http://purl.obolibrary.org/obo/CL_0001028` -#### Removed -- [CD7-positive lymphoid progenitor cell](http://purl.obolibrary.org/obo/CL_0001028) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- Class: [ATPase complex](http://purl.obolibrary.org/obo/GO_1904949) +- [ATPase complex](http://purl.obolibrary.org/obo/GO_1904949) EquivalentTo [protein-containing complex](http://purl.obolibrary.org/obo/GO_0032991) and ([capable of](http://purl.obolibrary.org/obo/RO_0002215) some [ATP hydrolysis activity](http://purl.obolibrary.org/obo/GO_0016887)) +- [ATPase complex](http://purl.obolibrary.org/obo/GO_1904949) SubClassOf [catalytic complex](http://purl.obolibrary.org/obo/GO_1902494) -### CD71-negative, GlyA-positive orthochromatic erythroblast `http://purl.obolibrary.org/obo/CL_0002018` -#### Removed -- [CD71-negative, GlyA-positive orthochromatic erythroblast](http://purl.obolibrary.org/obo/CL_0002018) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [ATPase complex](http://purl.obolibrary.org/obo/GO_1904949) SubClassOf [capable of](http://purl.obolibrary.org/obo/RO_0002215) some [ATP hydrolysis activity](http://purl.obolibrary.org/obo/GO_0016887) -### CD9-positive, CD41-positive megakaryocyte cell `http://purl.obolibrary.org/obo/CL_0002027` +### Atg1/ULK1 kinase complex `http://purl.obolibrary.org/obo/GO_1990316` #### Removed -- [CD9-positive, CD41-positive megakaryocyte cell](http://purl.obolibrary.org/obo/CL_0002027) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [Atg1/ULK1 kinase complex](http://purl.obolibrary.org/obo/GO_1990316) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "ULK1 complex" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:26921696" +- [Atg1/ULK1 kinase complex](http://purl.obolibrary.org/obo/GO_1990316) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "ATG1-ATG13 complex" +- [Atg1/ULK1 kinase complex](http://purl.obolibrary.org/obo/GO_1990316) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "ATG1 kinase complex" -### CNS neuron (sensu Nematoda and Protostomia) `http://purl.obolibrary.org/obo/CL_0000028` -#### Removed -- [CNS neuron (sensu Nematoda and Protostomia)](http://purl.obolibrary.org/obo/CL_0000028) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [Atg1/ULK1 kinase complex](http://purl.obolibrary.org/obo/GO_1990316) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "cellular_component" +- [Atg1/ULK1 kinase complex](http://purl.obolibrary.org/obo/GO_1990316) [label](http://www.w3.org/2000/01/rdf-schema#label) "Atg1/ULK1 kinase complex" +- [Atg1/ULK1 kinase complex](http://purl.obolibrary.org/obo/GO_1990316) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "ULK complex" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:28816597" -### CNS neuron (sensu Vertebrata) `http://purl.obolibrary.org/obo/CL_0000117` -#### Removed -- [CNS neuron (sensu Vertebrata)](http://purl.obolibrary.org/obo/CL_0000117) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [Atg1/ULK1 kinase complex](http://purl.obolibrary.org/obo/GO_1990316) [has_alternative_id](http://www.geneontology.org/formats/oboInOwl#hasAlternativeId) "GO:0070969" +- [Atg1/ULK1 kinase complex](http://purl.obolibrary.org/obo/GO_1990316) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "bhm" +- [Atg1/ULK1 kinase complex](http://purl.obolibrary.org/obo/GO_1990316) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "ATG1/ULK1 signaling complex" -### CX3C chemokine receptor 1 `http://purl.obolibrary.org/obo/PR_000001206` +- [Atg1/ULK1 kinase complex](http://purl.obolibrary.org/obo/GO_1990316) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A protein complex consisting of Atg1 (or Atg1 homologs e.g. ULK1, ULK2 in mammals) and Atg13 along with other proteins that regulate its function (e.g. Atg17 in yeast or RB1CC1(FIP200) in mammals). This complex has serine/threonine protein kinase activity and is involved in autophagosome formation." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:22885598" -#### Added -- [CX3C chemokine receptor 1](http://purl.obolibrary.org/obo/PR_000001206) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [CX3C chemokine receptor 1 (human)](http://purl.obolibrary.org/obo/PR_P49238) + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:19597335" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:bhm" -### D(1A) dopamine receptor `http://purl.obolibrary.org/obo/PR_000001175` + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:DOS" -#### Added -- [D(1A) dopamine receptor](http://purl.obolibrary.org/obo/PR_000001175) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [D(1A) dopamine receptor (human)](http://purl.obolibrary.org/obo/PR_P21728) + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:rb" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:15743910" -### D(2) dopamine receptor `http://purl.obolibrary.org/obo/PR_000001177` + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:19258318" -#### Added -- [D(2) dopamine receptor](http://purl.obolibrary.org/obo/PR_000001177) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [D(2) dopamine receptor (human)](http://purl.obolibrary.org/obo/PR_P14416) + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:19211835" +- [Atg1/ULK1 kinase complex](http://purl.obolibrary.org/obo/GO_1990316) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "ULK1-ATG13-FIP200 complex" -### DN1 thymic pro-T cell `http://purl.obolibrary.org/obo/CL_0000894` -#### Removed -- [DN1 thymic pro-T cell](http://purl.obolibrary.org/obo/CL_0000894) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [Atg1/ULK1 kinase complex](http://purl.obolibrary.org/obo/GO_1990316) [has_alternative_id](http://www.geneontology.org/formats/oboInOwl#hasAlternativeId) "GO:0034273" +- [Atg1/ULK1 kinase complex](http://purl.obolibrary.org/obo/GO_1990316) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "autophagy-initiation complex" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:autophagy" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:PARL" -### DN2 thymocyte `http://purl.obolibrary.org/obo/CL_0000806` -#### Removed -- [DN2 thymocyte](http://purl.obolibrary.org/obo/CL_0000806) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:pad" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:26754330" +- [Atg1/ULK1 kinase complex](http://purl.obolibrary.org/obo/GO_1990316) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:1990316" -### DN3 thymocyte `http://purl.obolibrary.org/obo/CL_0000807` -#### Removed -- [DN3 thymocyte](http://purl.obolibrary.org/obo/CL_0000807) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [Atg1/ULK1 kinase complex](http://purl.obolibrary.org/obo/GO_1990316) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "ULK1-ATG13-RB1CC1 complex" +- [Atg1/ULK1 kinase complex](http://purl.obolibrary.org/obo/GO_1990316) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "Atg1p signalling complex" +- [Atg1/ULK1 kinase complex](http://purl.obolibrary.org/obo/GO_1990316) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2014-03-14T10:55:11Z" -### DN4 thymocyte `http://purl.obolibrary.org/obo/CL_0000808` -#### Removed -- [DN4 thymocyte](http://purl.obolibrary.org/obo/CL_0000808) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [Atg1/ULK1 kinase complex](http://purl.obolibrary.org/obo/GO_1990316) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "ULK1 signaling complex" +- Class: [Atg1/ULK1 kinase complex](http://purl.obolibrary.org/obo/GO_1990316) +- [Atg1/ULK1 kinase complex](http://purl.obolibrary.org/obo/GO_1990316) SubClassOf [serine/threonine protein kinase complex](http://purl.obolibrary.org/obo/GO_1902554) -### DNA nucleotidylexotransferase `http://purl.obolibrary.org/obo/PR_000006611` +- [Atg1/ULK1 kinase complex](http://purl.obolibrary.org/obo/GO_1990316) SubClassOf [capable of part of](http://purl.obolibrary.org/obo/RO_0002216) some [autophagosome assembly](http://purl.obolibrary.org/obo/GO_0000045) -#### Added -- [DNA nucleotidylexotransferase](http://purl.obolibrary.org/obo/PR_000006611) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [DNA nucleotidylexotransferase (human)](http://purl.obolibrary.org/obo/PR_P04053) +- [Atg1/ULK1 kinase complex](http://purl.obolibrary.org/obo/GO_1990316) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [cytoplasm](http://purl.obolibrary.org/obo/GO_0005737) -### Dx5-negative, NK1.1-positive immature natural killer cell, mouse `http://purl.obolibrary.org/obo/CL_0002346` + +### Atg1/ULK1 kinase complex assembly `http://purl.obolibrary.org/obo/GO_1904745` #### Removed -- [Dx5-negative, NK1.1-positive immature natural killer cell, mouse](http://purl.obolibrary.org/obo/CL_0002346) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1904745) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2015-10-19T12:33:08Z" +- [Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1904745) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "Atg1p signalling complex assembly" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" +- [Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1904745) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "ATG1 kinase complex formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" -### GCIs -#### Removed -- [megakaryocyte](http://purl.obolibrary.org/obo/CL_0000556) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [lung connective tissue](http://purl.obolibrary.org/obo/UBERON_0000114)) SubClassOf [lung megakaryocyte](http://purl.obolibrary.org/obo/CL_4033018) +- [Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1904745) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "ULK1 signaling complex assembly" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" -#### Added -- [organogenesis stage](http://purl.obolibrary.org/obo/UBERON_0000111) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [Tetrapoda](http://purl.obolibrary.org/obo/NCBITaxon_32523)) SubClassOf [preceded by](http://purl.obolibrary.org/obo/BFO_0000062) some [neurula stage](http://purl.obolibrary.org/obo/UBERON_0000110) +- [Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1904745) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "ATG1 kinase complex assembly" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" +- [Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1904745) [label](http://www.w3.org/2000/01/rdf-schema#label) "Atg1/ULK1 kinase complex assembly" -### GlyA-positive erythrocyte `http://purl.obolibrary.org/obo/CL_0002021` -#### Removed -- [GlyA-positive erythrocyte](http://purl.obolibrary.org/obo/CL_0002021) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1904745) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "dph" +- [Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1904745) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "ATG1/ULK1 kinase complex formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" +- [Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1904745) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "ULK1 signaling complex formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" -### H1 horizontal cell `http://purl.obolibrary.org/obo/CL_0004217` +- [Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1904745) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "ULK1-ATG13-FIP200 complex assembly" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" -#### Added -- [H1 horizontal cell](http://purl.obolibrary.org/obo/CL_0004217) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "H1" - - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation) +- [Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1904745) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1038/s41598-020-66092-9" +- [Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1904745) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "ATG1/ULK1 signaling complex formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" +- [Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1904745) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "Atg1p signalling complex formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" -### H2 horizontal cell `http://purl.obolibrary.org/obo/CL_0004218` +- [Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1904745) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "ULK1-ATG13-FIP200 complex formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" -#### Added -- [H2 horizontal cell](http://purl.obolibrary.org/obo/CL_0004218) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "H2" - - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation) +- [Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1904745) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "ATG1-ATG13 complex assembly" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1038/s41598-020-66092-9" +- [Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1904745) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The aggregation, arrangement and bonding together of a set of components to form an Atg1/UKL1 kinase complex." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:25139988" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dph" -### ILC1, human `http://purl.obolibrary.org/obo/CL_0001077` -#### Removed -- [ILC1, human](http://purl.obolibrary.org/obo/CL_0001077) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GO_REF:0000079" +- [Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1904745) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "ATG1-ATG13 complex formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" -### Kit and Sca1-positive hematopoietic stem cell `http://purl.obolibrary.org/obo/CL_0001008` -#### Removed -- [Kit and Sca1-positive hematopoietic stem cell](http://purl.obolibrary.org/obo/CL_0001008) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1904745) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "ULK1-ATG13-RB1CC1 complex assembly" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" +- [Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1904745) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:1904745" +- [Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1904745) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "ULK1-ATG13-RB1CC1 complex formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" -### Kit-negative, Ly-76 high orthochromatophilic erythroblasts `http://purl.obolibrary.org/obo/CL_0002017` -#### Removed -- [Kit-negative, Ly-76 high orthochromatophilic erythroblasts](http://purl.obolibrary.org/obo/CL_0002017) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1904745) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "ATG1/ULK1 signaling complex assembly" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" +- Class: [Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1904745) +- [Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1904745) EquivalentTo [cellular component assembly](http://purl.obolibrary.org/obo/GO_0022607) and ([results in assembly of](http://purl.obolibrary.org/obo/RO_0002588) some [Atg1/ULK1 kinase complex](http://purl.obolibrary.org/obo/GO_1990316)) -### Kit-positive macrophage dendritic cell progenitor `http://purl.obolibrary.org/obo/CL_0002011` -#### Removed -- [Kit-positive macrophage dendritic cell progenitor](http://purl.obolibrary.org/obo/CL_0002011) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1904745) SubClassOf [results in assembly of](http://purl.obolibrary.org/obo/RO_0002588) some [Atg1/ULK1 kinase complex](http://purl.obolibrary.org/obo/GO_1990316) +- [Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1904745) SubClassOf [protein-containing complex assembly](http://purl.obolibrary.org/obo/GO_0065003) -### Kit-positive megakaryocyte progenitor cell `http://purl.obolibrary.org/obo/CL_0002024` + +### Atg12 activating enzyme activity `http://purl.obolibrary.org/obo/GO_0019778` #### Removed -- [Kit-positive megakaryocyte progenitor cell](http://purl.obolibrary.org/obo/CL_0002024) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [Atg12 activating enzyme activity](http://purl.obolibrary.org/obo/GO_0019778) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "molecular_function" +- [Atg12 activating enzyme activity](http://purl.obolibrary.org/obo/GO_0019778) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "APG12 activating enzyme activity" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:vw" +- [Atg12 activating enzyme activity](http://purl.obolibrary.org/obo/GO_0019778) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Catalysis of the activation of the small ubiquitin-related modifier APG12, through the formation of an ATP-dependent high-energy thiolester bond." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:mah" -### Kit-positive, CD34-negative megakaryocyte erythroid progenitor cell `http://purl.obolibrary.org/obo/CL_0002006` -#### Removed -- [Kit-positive, CD34-negative megakaryocyte erythroid progenitor cell](http://purl.obolibrary.org/obo/CL_0002006) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [Atg12 activating enzyme activity](http://purl.obolibrary.org/obo/GO_0019778) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0019778" +- [Atg12 activating enzyme activity](http://purl.obolibrary.org/obo/GO_0019778) [label](http://www.w3.org/2000/01/rdf-schema#label) "Atg12 activating enzyme activity" +- Class: [Atg12 activating enzyme activity](http://purl.obolibrary.org/obo/GO_0019778) -### Kit-positive, Sca1-positive common lymphoid progenitor `http://purl.obolibrary.org/obo/CL_0001025` -#### Removed -- [Kit-positive, Sca1-positive common lymphoid progenitor](http://purl.obolibrary.org/obo/CL_0001025) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [Atg12 activating enzyme activity](http://purl.obolibrary.org/obo/GO_0019778) SubClassOf [ubiquitin-like modifier activating enzyme activity](http://purl.obolibrary.org/obo/GO_0008641) -### Kupffer cell `http://purl.obolibrary.org/obo/CL_0000091` +### Atg12 conjugating enzyme activity `http://purl.obolibrary.org/obo/GO_0061651` #### Removed -- [Kupffer cell](http://purl.obolibrary.org/obo/CL_0000091) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) - +- [Atg12 conjugating enzyme activity](http://purl.obolibrary.org/obo/GO_0061651) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0061651" +- [Atg12 conjugating enzyme activity](http://purl.obolibrary.org/obo/GO_0061651) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "E2" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dph" -### L-selectin `http://purl.obolibrary.org/obo/PR_000001318` +- [Atg12 conjugating enzyme activity](http://purl.obolibrary.org/obo/GO_0061651) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "molecular_function" -#### Added -- [L-selectin](http://purl.obolibrary.org/obo/PR_000001318) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [L-selectin (human)](http://purl.obolibrary.org/obo/PR_P14151) +- [Atg12 conjugating enzyme activity](http://purl.obolibrary.org/obo/GO_0061651) [label](http://www.w3.org/2000/01/rdf-schema#label) "Atg12 conjugating enzyme activity" +- [Atg12 conjugating enzyme activity](http://purl.obolibrary.org/obo/GO_0061651) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "dph" -### L2/3 bipolar vip GABAergic cortical interneuron (Mmus) `http://purl.obolibrary.org/obo/CL_4023007` +- [Atg12 conjugating enzyme activity](http://purl.obolibrary.org/obo/GO_0061651) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2014-11-06T13:17:36Z" -#### Added -- [L2/3 bipolar vip GABAergic cortical interneuron (Mmus)](http://purl.obolibrary.org/obo/CL_4023007) [symbol](http://purl.obolibrary.org/obo/IAO_0000028) "L2/3 bipolar vip interneuron (Mus)" +- [Atg12 conjugating enzyme activity](http://purl.obolibrary.org/obo/GO_0061651) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Isoenergetic transfer of Atg12 from one protein to another via the reaction X-Atg12 + Y = Y-Atg12 + X, where both the X-Atg12 and Y-Atg12 linkages are thioester bonds between the C-terminal amino acid of Atg12 and a sulfhydryl side group of a cysteine residue." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dph" +- Class: [Atg12 conjugating enzyme activity](http://purl.obolibrary.org/obo/GO_0061651) -### L2/3 intratelencephalic projecting glutamatergic neuron of the primary motor cortex `http://purl.obolibrary.org/obo/CL_4023047` +- [Atg12 conjugating enzyme activity](http://purl.obolibrary.org/obo/GO_0061651) SubClassOf [ubiquitin-like protein conjugating enzyme activity](http://purl.obolibrary.org/obo/GO_0061650) -#### Added -- [L2/3 intratelencephalic projecting glutamatergic neuron of the primary motor cortex](http://purl.obolibrary.org/obo/CL_4023047) [symbol](http://purl.obolibrary.org/obo/IAO_0000028) "L2/3 IT glut MOp" +- [Atg12 conjugating enzyme activity](http://purl.obolibrary.org/obo/GO_0061651) SubClassOf [Atg12 transferase activity](http://purl.obolibrary.org/obo/GO_0019777) -### L2/3-6 intratelencephalic projecting glutamatergic cortical neuron `http://purl.obolibrary.org/obo/CL_4023040` -#### Added -- [L2/3-6 intratelencephalic projecting glutamatergic cortical neuron](http://purl.obolibrary.org/obo/CL_4023040) [symbol](http://purl.obolibrary.org/obo/IAO_0000028) "L2/3-6 IT glut" +### Atg12 ligase activity `http://purl.obolibrary.org/obo/GO_0061660` +#### Removed +- [Atg12 ligase activity](http://purl.obolibrary.org/obo/GO_0061660) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "dph" +- [Atg12 ligase activity](http://purl.obolibrary.org/obo/GO_0061660) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "molecular_function" -### L2/3/5 fan Martinotti sst GABAergic cortical interneuron (Mmus) `http://purl.obolibrary.org/obo/CL_4023030` +- [Atg12 ligase activity](http://purl.obolibrary.org/obo/GO_0061660) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0061660" -#### Added -- [L2/3/5 fan Martinotti sst GABAergic cortical interneuron (Mmus)](http://purl.obolibrary.org/obo/CL_4023030) [symbol](http://purl.obolibrary.org/obo/IAO_0000028) "L2/3/5 fan Martinotti sst interneuron (Mus)" +- [Atg12 ligase activity](http://purl.obolibrary.org/obo/GO_0061660) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "E3" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dph" +- [Atg12 ligase activity](http://purl.obolibrary.org/obo/GO_0061660) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Catalysis of the transfer of Atg12 to a substrate protein via the reaction X-Atg12 + S = X + S-Atg12, where X is either an E2 or E3 enzyme, the X-Atg12 linkage is a thioester bond, and the S-Atg12 linkage is an isopeptide bond between the C-terminal amino acid of Atg12 and the epsilon-amino group of lysine residues in the substrate." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dph" -### L4 sst GABAergic cortical interneuron (Mmus) `http://purl.obolibrary.org/obo/CL_4023031` +- [Atg12 ligase activity](http://purl.obolibrary.org/obo/GO_0061660) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2014-11-06T13:50:42Z" -#### Added -- [L4 sst GABAergic cortical interneuron (Mmus)](http://purl.obolibrary.org/obo/CL_4023031) [symbol](http://purl.obolibrary.org/obo/IAO_0000028) "L4 sst interneuron (Mus)" +- [Atg12 ligase activity](http://purl.obolibrary.org/obo/GO_0061660) [label](http://www.w3.org/2000/01/rdf-schema#label) "Atg12 ligase activity" +- Class: [Atg12 ligase activity](http://purl.obolibrary.org/obo/GO_0061660) -### L4/5 intratelencephalic projecting glutamatergic neuron of the primary motor cortex `http://purl.obolibrary.org/obo/CL_4023048` +- [Atg12 ligase activity](http://purl.obolibrary.org/obo/GO_0061660) SubClassOf [ubiquitin-like protein ligase activity](http://purl.obolibrary.org/obo/GO_0061659) -#### Added -- [L4/5 intratelencephalic projecting glutamatergic neuron of the primary motor cortex](http://purl.obolibrary.org/obo/CL_4023048) [symbol](http://purl.obolibrary.org/obo/IAO_0000028) "L4/5 IT glut MOp" +- [Atg12 ligase activity](http://purl.obolibrary.org/obo/GO_0061660) SubClassOf [Atg12 transferase activity](http://purl.obolibrary.org/obo/GO_0019777) -### L5 T-Martinotti sst GABAergic cortical interneuron (Mmus) `http://purl.obolibrary.org/obo/CL_4023027` -#### Added -- [L5 T-Martinotti sst GABAergic cortical interneuron (Mmus)](http://purl.obolibrary.org/obo/CL_4023027) [symbol](http://purl.obolibrary.org/obo/IAO_0000028) "L5 T Martinotti sst interneuron (Mus)" +### Atg12 transferase activity `http://purl.obolibrary.org/obo/GO_0019777` +#### Removed +- [Atg12 transferase activity](http://purl.obolibrary.org/obo/GO_0019777) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "APG12 ligase activity" +- [Atg12 transferase activity](http://purl.obolibrary.org/obo/GO_0019777) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "Atg12 conjugating enzyme activity" -### L5 extratelencephalic projecting glutamatergic cortical neuron `http://purl.obolibrary.org/obo/CL_4023041` +- [Atg12 transferase activity](http://purl.obolibrary.org/obo/GO_0019777) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "molecular_function" -#### Added -- [L5 extratelencephalic projecting glutamatergic cortical neuron](http://purl.obolibrary.org/obo/CL_4023041) [symbol](http://purl.obolibrary.org/obo/IAO_0000028) "L5 ET glut" +- [Atg12 transferase activity](http://purl.obolibrary.org/obo/GO_0019777) [label](http://www.w3.org/2000/01/rdf-schema#label) "Atg12 transferase activity" +- [Atg12 transferase activity](http://purl.obolibrary.org/obo/GO_0019777) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "Atg12 ligase activity" -### L5 intratelencephalic projecting glutamatergic neuron of the primary motor cortex `http://purl.obolibrary.org/obo/CL_4023049` +- [Atg12 transferase activity](http://purl.obolibrary.org/obo/GO_0019777) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Catalysis of the transfer of ATG12 from one protein to another via the reaction X-ATG12 + Y = Y-ATG12 + X, where both X-ATG12 and Y-ATG12 are covalent linkages." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:mah" -#### Added -- [L5 intratelencephalic projecting glutamatergic neuron of the primary motor cortex](http://purl.obolibrary.org/obo/CL_4023049) [symbol](http://purl.obolibrary.org/obo/IAO_0000028) "L5 IT glut MOp" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:12826404" +- [Atg12 transferase activity](http://purl.obolibrary.org/obo/GO_0019777) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "APG12 conjugating enzyme activity" -### L5 non-Martinotti sst GABAergic cortical interneuron (Mmus) `http://purl.obolibrary.org/obo/CL_4023028` +- [Atg12 transferase activity](http://purl.obolibrary.org/obo/GO_0019777) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-5681999" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "ATG10 transfers ATG12 from ATG7 to ATG10" -#### Added -- [L5 non-Martinotti sst GABAergic cortical interneuron (Mmus)](http://purl.obolibrary.org/obo/CL_4023028) [symbol](http://purl.obolibrary.org/obo/IAO_0000028) "L5 non-Martinotti sst interneuron (Mus)" +- [Atg12 transferase activity](http://purl.obolibrary.org/obo/GO_0019777) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0019777" +- Class: [Atg12 transferase activity](http://purl.obolibrary.org/obo/GO_0019777) -### L5 vip cortical GABAergic interneuron (Mmus) `http://purl.obolibrary.org/obo/CL_4023014` +- [Atg12 transferase activity](http://purl.obolibrary.org/obo/GO_0019777) SubClassOf [ubiquitin-like protein transferase activity](http://purl.obolibrary.org/obo/GO_0019787) -#### Added -- [L5 vip cortical GABAergic interneuron (Mmus)](http://purl.obolibrary.org/obo/CL_4023014) [symbol](http://purl.obolibrary.org/obo/IAO_0000028) "L5 vip interneuron (Mus)" -### L5,6 neurogliaform lamp5 GABAergic cortical interneuron (Mmus) `http://purl.obolibrary.org/obo/CL_4023023` +### BFO_0000001 `http://purl.obolibrary.org/obo/BFO_0000001` +#### Removed +- Class: [BFO_0000001](http://purl.obolibrary.org/obo/BFO_0000001) -#### Added -- [L5,6 neurogliaform lamp5 GABAergic cortical interneuron (Mmus)](http://purl.obolibrary.org/obo/CL_4023023) [symbol](http://purl.obolibrary.org/obo/IAO_0000028) "L5,6 NGC Lamp5 interneuron (Mus)" -### L5/6 cck cortical GABAergic interneuron (Mmus) `http://purl.obolibrary.org/obo/CL_4023071` +### CHEBI_39124 `http://purl.obolibrary.org/obo/CHEBI_39124` #### Added -- [L5/6 cck cortical GABAergic interneuron (Mmus)](http://purl.obolibrary.org/obo/CL_4023071) [symbol](http://purl.obolibrary.org/obo/IAO_0000028) "L5/6 cck interneuron (Mus)" +- Class: [CHEBI_39124](http://purl.obolibrary.org/obo/CHEBI_39124) -### L5/6 near-projecting glutamatergic neuron of the primary motor cortex `http://purl.obolibrary.org/obo/CL_4023043` +### CHEBI_43474 `http://purl.obolibrary.org/obo/CHEBI_43474` +#### Removed +- Class: [CHEBI_43474](http://purl.obolibrary.org/obo/CHEBI_43474) -#### Added -- [L5/6 near-projecting glutamatergic neuron of the primary motor cortex](http://purl.obolibrary.org/obo/CL_4023043) [symbol](http://purl.obolibrary.org/obo/IAO_0000028) "L5/6 NP glut MOp" -### L5/6 non-Martinotti sst GABAergic cortical interneuron (Mmus) `http://purl.obolibrary.org/obo/CL_4023118` +### CHEBI_57930 `http://purl.obolibrary.org/obo/CHEBI_57930` +#### Removed +- Class: [CHEBI_57930](http://purl.obolibrary.org/obo/CHEBI_57930) -#### Added -- [L5/6 non-Martinotti sst GABAergic cortical interneuron (Mmus)](http://purl.obolibrary.org/obo/CL_4023118) [symbol](http://purl.obolibrary.org/obo/IAO_0000028) "L5/6 non-Martinotti sst interneuron (Mus)" -### L6 corticothalamic-projecting glutamatergic cortical neuron `http://purl.obolibrary.org/obo/CL_4023042` +### CHEBI_61557 `http://purl.obolibrary.org/obo/CHEBI_61557` +#### Removed +- Class: [CHEBI_61557](http://purl.obolibrary.org/obo/CHEBI_61557) -#### Added -- [L6 corticothalamic-projecting glutamatergic cortical neuron](http://purl.obolibrary.org/obo/CL_4023042) [symbol](http://purl.obolibrary.org/obo/IAO_0000028) "L6 CT glut" -### L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex `http://purl.obolibrary.org/obo/CL_4023050` +### D1/D2-hybrid medium spiny neuron `http://purl.obolibrary.org/obo/CL_4030050` +#### Removed +- [D1/D2-hybrid medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030050) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "hybrid D1/2 cell type" + - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation) -#### Added -- [L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex](http://purl.obolibrary.org/obo/CL_4023050) [symbol](http://purl.obolibrary.org/obo/IAO_0000028) "L6 IT glut MOp" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) [j.cub.2021.10.015](DOI:10.1016/j.cub.2021.10.015) +- [D1/D2-hybrid medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030050) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A medium spiny neuron that expresses both DRD1 and DRD2 and is part of an extra-striosomal part of dorsal striatum." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) [j.cub.2021.10.015](DOI:10.1016/j.cub.2021.10.015) -### L6 tyrosine hydroxylase sst GABAergic cortical interneuron (Mmus) `http://purl.obolibrary.org/obo/CL_4023075` +- [D1/D2-hybrid medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030050) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "D1/2" + - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation) -#### Added -- [L6 tyrosine hydroxylase sst GABAergic cortical interneuron (Mmus)](http://purl.obolibrary.org/obo/CL_4023075) [symbol](http://purl.obolibrary.org/obo/IAO_0000028) "L6 th sst interneuron (Mus)" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) [j.cub.2021.10.015](DOI:10.1016/j.cub.2021.10.015) +- [D1/D2-hybrid medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030050) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "D1/D2-hybrid MSN" + - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation) -### L6b glutamatergic cortical neuron `http://purl.obolibrary.org/obo/CL_4023038` + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) [j.cub.2021.10.015](DOI:10.1016/j.cub.2021.10.015) -#### Added -- [L6b glutamatergic cortical neuron](http://purl.obolibrary.org/obo/CL_4023038) [symbol](http://purl.obolibrary.org/obo/IAO_0000028) "L6b glut" +- [D1/D2-hybrid medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030050) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "D1/D2 hybrid" + - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation) + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) [j.cub.2021.10.015](DOI:10.1016/j.cub.2021.10.015) -### L6b subplate glutamatergic neuron of the primary motor cortex `http://purl.obolibrary.org/obo/CL_4023046` +- [D1/D2-hybrid medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030050) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "It has been noted in non-human primate species that the D1/D2-hybrid medium spiny neuron (D1/2) cell type shows the same amount of DRD1 expression as nearby D1 medium spiny neurons but far less DRD2 expression compared to nearby D2 medium spiny neurons. In Rhesus macaques, RXFP1 has been noted as a highly specific marker gene for the D1/2 cell type. The D1/2 cell type has also been described as having characteristics similar to a novel medium spiny neuron described in rodents (D1H or eccentric spiny projection neuron). Although an extrastriosomal cell type, the D1/2 cell type had been noted to express many of the genes associated with striosome, suggesting a possible homology to ‘‘exo-patch’’ cells." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) [j.cub.2021.10.015](DOI:10.1016/j.cub.2021.10.015) #### Added -- [L6b subplate glutamatergic neuron of the primary motor cortex](http://purl.obolibrary.org/obo/CL_4023046) [symbol](http://purl.obolibrary.org/obo/IAO_0000028) "L6b subplate glut" +- [D1/D2-hybrid medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030050) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "hybrid D1/2 cell type" + - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation) + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/j.cub.2021.10.015" -### Leydig cell `http://purl.obolibrary.org/obo/CL_0000178` -#### Removed -- [Leydig cell](http://purl.obolibrary.org/obo/CL_0000178) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [D1/D2-hybrid medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030050) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "D1/D2-hybrid MSN" + - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation) + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/j.cub.2021.10.015" +- [D1/D2-hybrid medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030050) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "D1/D2 hybrid" + - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation) -### Leydig cell region of testis `http://purl.obolibrary.org/obo/UBERON_0005212` -#### Removed -- [Leydig cell region of testis](http://purl.obolibrary.org/obo/UBERON_0005212) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/j.cub.2021.10.015" +- [D1/D2-hybrid medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030050) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A medium spiny neuron that expresses both DRD1 and DRD2 and is part of an extra-striosomal part of dorsal striatum." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/j.cub.2021.10.015" +- [D1/D2-hybrid medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030050) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "D1/2" + - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation) -### Ly-76 high positive erythrocyte `http://purl.obolibrary.org/obo/CL_0002022` -#### Removed -- [Ly-76 high positive erythrocyte](http://purl.obolibrary.org/obo/CL_0002022) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/j.cub.2021.10.015" +- [D1/D2-hybrid medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030050) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "It has been noted in non-human primate species that the D1/D2-hybrid medium spiny neuron (D1/2) cell type shows the same amount of DRD1 expression as nearby D1 medium spiny neurons but far less DRD2 expression compared to nearby D2 medium spiny neurons. In Rhesus macaques, RXFP1 has been noted as a highly specific marker gene for the D1/2 cell type. The D1/2 cell type has also been described as having characteristics similar to a novel medium spiny neuron described in rodents (D1H or eccentric spiny projection neuron). Although an extrastriosomal cell type, the D1/2 cell type had been noted to express many of the genes associated with striosome, suggesting a possible homology to ‘‘exo-patch’’ cells." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/j.cub.2021.10.015" -### Mueller cell `http://purl.obolibrary.org/obo/CL_0000636` +### Feyrter cell `http://purl.obolibrary.org/obo/CL_0002066` +#### Removed +- [Feyrter cell](http://purl.obolibrary.org/obo/CL_0002066) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "P cell" #### Added -- [Mueller cell](http://purl.obolibrary.org/obo/CL_0000636) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "Muller cell" - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.21769/BioProtoc.4179" - - - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [a mis-spelling that is in common use and thus recorded](http://purl.obolibrary.org/obo/uberon/core#MISSPELLING) +- [Feyrter cell](http://purl.obolibrary.org/obo/CL_0002066) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "P cell" + - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation) -### NK1.1-positive natural killer cell, mouse `http://purl.obolibrary.org/obo/CL_0002438` +### GABAergic neuron `http://purl.obolibrary.org/obo/CL_0000617` #### Removed -- [NK1.1-positive natural killer cell, mouse](http://purl.obolibrary.org/obo/CL_0002438) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [GABAergic neuron](http://purl.obolibrary.org/obo/CL_0000617) SubClassOf [acid secreting cell](http://purl.obolibrary.org/obo/CL_0000161) +#### Added +- [GABAergic neuron](http://purl.obolibrary.org/obo/CL_0000617) SubClassOf [secretory cell](http://purl.obolibrary.org/obo/CL_0000151) -### NKG2-A/NKG2-B type II integral membrane protein `http://purl.obolibrary.org/obo/PR_000002023` +### GCIs #### Added -- [NKG2-A/NKG2-B type II integral membrane protein](http://purl.obolibrary.org/obo/PR_000002023) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [NKG2-A/NKG2-B type II integral membrane protein (human)](http://purl.obolibrary.org/obo/PR_P26715) +- [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [nucleus](http://purl.obolibrary.org/obo/GO_0005634) DisjointWith [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [cytosol](http://purl.obolibrary.org/obo/GO_0005829) -### OMO_0001000 `http://purl.obolibrary.org/obo/OMO_0001000` +### Golgi to lysosome transport `http://purl.obolibrary.org/obo/GO_0090160` #### Added -- Individual: [OMO_0001000](http://purl.obolibrary.org/obo/OMO_0001000) +- [Golgi to lysosome transport](http://purl.obolibrary.org/obo/GO_0090160) [label](http://www.w3.org/2000/01/rdf-schema#label) "Golgi to lysosome transport" +- [Golgi to lysosome transport](http://purl.obolibrary.org/obo/GO_0090160) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0090160" -### ON-bipolar cell `http://purl.obolibrary.org/obo/CL_0000749` -#### Removed -- [ON-bipolar cell](http://purl.obolibrary.org/obo/CL_0000749) SubClassOf [has soma location](http://purl.obolibrary.org/obo/RO_0002100) some [inner nuclear layer of retina](http://purl.obolibrary.org/obo/UBERON_0001791) +- [Golgi to lysosome transport](http://purl.obolibrary.org/obo/GO_0090160) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" +- [Golgi to lysosome transport](http://purl.obolibrary.org/obo/GO_0090160) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The directed movement of substances from the Golgi to lysosomes." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dph" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:ascb_2009" -### Purkinje cell layer of cerebellar cortex `http://purl.obolibrary.org/obo/UBERON_0002979` -#### Removed -- [Purkinje cell layer of cerebellar cortex](http://purl.obolibrary.org/obo/UBERON_0002979) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:tb" +- [Golgi to lysosome transport](http://purl.obolibrary.org/obo/GO_0090160) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "tb" +- [Golgi to lysosome transport](http://purl.obolibrary.org/obo/GO_0090160) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2009-12-08T08:35:13Z" -### S-shaped body `http://purl.obolibrary.org/obo/UBERON_0004199` -#### Removed -- [S-shaped body](http://purl.obolibrary.org/obo/UBERON_0004199) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- Class: [Golgi to lysosome transport](http://purl.obolibrary.org/obo/GO_0090160) +- [Golgi to lysosome transport](http://purl.obolibrary.org/obo/GO_0090160) EquivalentTo [vesicle-mediated transport](http://purl.obolibrary.org/obo/GO_0016192) and ([occurs in](http://purl.obolibrary.org/obo/BFO_0000066) some [cytosol](http://purl.obolibrary.org/obo/GO_0005829)) and ([has target start location](http://purl.obolibrary.org/obo/RO_0002338) some [Golgi apparatus](http://purl.obolibrary.org/obo/GO_0005794)) and ([has target end location](http://purl.obolibrary.org/obo/RO_0002339) some [lysosome](http://purl.obolibrary.org/obo/GO_0005764)) +- [Golgi to lysosome transport](http://purl.obolibrary.org/obo/GO_0090160) SubClassOf [cytosolic transport](http://purl.obolibrary.org/obo/GO_0016482) -### SCO-spondin `http://purl.obolibrary.org/obo/PR_000015658` +- [Golgi to lysosome transport](http://purl.obolibrary.org/obo/GO_0090160) SubClassOf [has target end location](http://purl.obolibrary.org/obo/RO_0002339) some [lysosome](http://purl.obolibrary.org/obo/GO_0005764) -#### Added -- [SCO-spondin](http://purl.obolibrary.org/obo/PR_000015658) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [SCO-spondin (human)](http://purl.obolibrary.org/obo/PR_A2VEC9) +- [Golgi to lysosome transport](http://purl.obolibrary.org/obo/GO_0090160) SubClassOf [lysosomal transport](http://purl.obolibrary.org/obo/GO_0007041) +- [Golgi to lysosome transport](http://purl.obolibrary.org/obo/GO_0090160) SubClassOf [Golgi to vacuole transport](http://purl.obolibrary.org/obo/GO_0006896) -### SLAM family member 5 `http://purl.obolibrary.org/obo/PR_000001319` + +### L-glutamate import across plasma membrane `http://purl.obolibrary.org/obo/GO_0098712` #### Added -- [SLAM family member 5](http://purl.obolibrary.org/obo/PR_000001319) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [SLAM family member 5 (human)](http://purl.obolibrary.org/obo/PR_Q9UIB8) +- [L-glutamate import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098712) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" +- [L-glutamate import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098712) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "L-glutamate(1-) import into cell" -### T-box transcription factor TBX21 `http://purl.obolibrary.org/obo/PR_000001835` +- [L-glutamate import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098712) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0098712" -#### Added -- [T-box transcription factor TBX21](http://purl.obolibrary.org/obo/PR_000001835) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [T-box transcription factor TBX21 (human)](http://purl.obolibrary.org/obo/PR_Q9UL17) +- [L-glutamate import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098712) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "L-glutamate import into cell" +- [L-glutamate import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098712) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2013-06-12T12:32:47Z" -### T-cell acute lymphocytic leukemia protein 1 `http://purl.obolibrary.org/obo/PR_000016043` +- [L-glutamate import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098712) [has_alternative_id](http://www.geneontology.org/formats/oboInOwl#hasAlternativeId) "GO:1903802" -#### Added -- [T-cell acute lymphocytic leukemia protein 1](http://purl.obolibrary.org/obo/PR_000016043) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [T-cell acute lymphocytic leukemia protein 1 (human)](http://purl.obolibrary.org/obo/PR_P17542) +- [L-glutamate import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098712) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "L-glutamate(1-) import across plasma membrane" +- [L-glutamate import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098712) [has_alternative_id](http://www.geneontology.org/formats/oboInOwl#hasAlternativeId) "GO:1990123" -### T-cell surface glycoprotein CD1a `http://purl.obolibrary.org/obo/PR_000002025` +- [L-glutamate import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098712) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "mah" -#### Added -- [T-cell surface glycoprotein CD1a](http://purl.obolibrary.org/obo/PR_000002025) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [T-cell surface glycoprotein CD1a (human)](http://purl.obolibrary.org/obo/PR_P06126) +- [L-glutamate import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098712) [label](http://www.w3.org/2000/01/rdf-schema#label) "L-glutamate import across plasma membrane" +- [L-glutamate import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098712) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The directed movement of L-glutamate from outside of a cell, across the plasma membrane and into the cytosol." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dos" -### T-cell surface glycoprotein CD1c `http://purl.obolibrary.org/obo/PR_000002027` +- Class: [L-glutamate import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098712) -#### Added -- [T-cell surface glycoprotein CD1c](http://purl.obolibrary.org/obo/PR_000002027) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [T-cell surface glycoprotein CD1c (human)](http://purl.obolibrary.org/obo/PR_P29017) +- [L-glutamate import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098712) EquivalentTo [transport](http://purl.obolibrary.org/obo/GO_0006810) and ([has target start location](http://purl.obolibrary.org/obo/RO_0002338) some [extracellular region](http://purl.obolibrary.org/obo/GO_0005576)) and ([has target end location](http://purl.obolibrary.org/obo/RO_0002339) some [cytosol](http://purl.obolibrary.org/obo/GO_0005829)) and ([results in transport across](http://purl.obolibrary.org/obo/RO_0002342) some [plasma membrane](http://purl.obolibrary.org/obo/GO_0005886)) and ([has primary input](http://purl.obolibrary.org/obo/RO_0004009) some [CHEBI_29985](http://purl.obolibrary.org/obo/CHEBI_29985)) + +- [L-glutamate import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098712) SubClassOf [L-glutamate transmembrane transport](http://purl.obolibrary.org/obo/GO_0015813) + +- [L-glutamate import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098712) SubClassOf [amino acid import across plasma membrane](http://purl.obolibrary.org/obo/GO_0089718) -### T-cell surface glycoprotein CD5 `http://purl.obolibrary.org/obo/PR_000001839` +### L-glutamate transmembrane export from vacuole `http://purl.obolibrary.org/obo/GO_0089704` #### Added -- [T-cell surface glycoprotein CD5](http://purl.obolibrary.org/obo/PR_000001839) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [T-cell surface glycoprotein CD5 (human)](http://purl.obolibrary.org/obo/PR_P06127) +- [L-glutamate transmembrane export from vacuole](http://purl.obolibrary.org/obo/GO_0089704) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0089704" +- [L-glutamate transmembrane export from vacuole](http://purl.obolibrary.org/obo/GO_0089704) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" -### T-cell surface glycoprotein CD8 alpha chain `http://purl.obolibrary.org/obo/PR_000001084` +- [L-glutamate transmembrane export from vacuole](http://purl.obolibrary.org/obo/GO_0089704) [label](http://www.w3.org/2000/01/rdf-schema#label) "L-glutamate transmembrane export from vacuole" -#### Added -- [T-cell surface glycoprotein CD8 alpha chain](http://purl.obolibrary.org/obo/PR_000001084) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [T-cell surface glycoprotein CD8 alpha chain (human)](http://purl.obolibrary.org/obo/PR_P01732) +- [L-glutamate transmembrane export from vacuole](http://purl.obolibrary.org/obo/GO_0089704) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The directed movement of L-glutamate out of the vacuole, across the vacuolar membrane." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:21307582" +- Class: [L-glutamate transmembrane export from vacuole](http://purl.obolibrary.org/obo/GO_0089704) -### T-cell surface glycoprotein CD8 alpha chain isoform 1 `http://purl.obolibrary.org/obo/PR_000025403` +- [L-glutamate transmembrane export from vacuole](http://purl.obolibrary.org/obo/GO_0089704) EquivalentTo [transport](http://purl.obolibrary.org/obo/GO_0006810) and ([has target start location](http://purl.obolibrary.org/obo/RO_0002338) some [vacuolar lumen](http://purl.obolibrary.org/obo/GO_0005775)) and ([has target end location](http://purl.obolibrary.org/obo/RO_0002339) some [cytosol](http://purl.obolibrary.org/obo/GO_0005829)) and ([results in transport across](http://purl.obolibrary.org/obo/RO_0002342) some [membrane](http://purl.obolibrary.org/obo/GO_0016020)) and ([has primary input](http://purl.obolibrary.org/obo/RO_0004009) some [CHEBI_29985](http://purl.obolibrary.org/obo/CHEBI_29985)) -#### Added -- [T-cell surface glycoprotein CD8 alpha chain isoform 1](http://purl.obolibrary.org/obo/PR_000025403) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [T-cell surface glycoprotein CD8 alpha chain isoform 1 (human)](http://purl.obolibrary.org/obo/PR_P01732-1) +- [L-glutamate transmembrane export from vacuole](http://purl.obolibrary.org/obo/GO_0089704) SubClassOf [L-glutamate transmembrane transport](http://purl.obolibrary.org/obo/GO_0015813) +- [L-glutamate transmembrane export from vacuole](http://purl.obolibrary.org/obo/GO_0089704) SubClassOf [amino acid transmembrane export from vacuole](http://purl.obolibrary.org/obo/GO_0032974) -### T-cell surface glycoprotein CD8 beta chain `http://purl.obolibrary.org/obo/PR_000001085` + +### L-glutamate transmembrane import into vacuole `http://purl.obolibrary.org/obo/GO_0090515` #### Added -- [T-cell surface glycoprotein CD8 beta chain](http://purl.obolibrary.org/obo/PR_000001085) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [T-cell surface glycoprotein CD8 beta chain (human)](http://purl.obolibrary.org/obo/PR_P10966) +- [L-glutamate transmembrane import into vacuole](http://purl.obolibrary.org/obo/GO_0090515) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" +- [L-glutamate transmembrane import into vacuole](http://purl.obolibrary.org/obo/GO_0090515) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0090515" -### T-cell-specific surface glycoprotein CD28 `http://purl.obolibrary.org/obo/PR_000001841` +- [L-glutamate transmembrane import into vacuole](http://purl.obolibrary.org/obo/GO_0090515) [label](http://www.w3.org/2000/01/rdf-schema#label) "L-glutamate transmembrane import into vacuole" -#### Added -- [T-cell-specific surface glycoprotein CD28](http://purl.obolibrary.org/obo/PR_000001841) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [T-cell-specific surface glycoprotein CD28 (human)](http://purl.obolibrary.org/obo/PR_P10747) +- [L-glutamate transmembrane import into vacuole](http://purl.obolibrary.org/obo/GO_0090515) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2012-12-14T11:25:52Z" +- [L-glutamate transmembrane import into vacuole](http://purl.obolibrary.org/obo/GO_0090515) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "tb" -### Thy-1 membrane glycoprotein `http://purl.obolibrary.org/obo/PR_000001843` +- [L-glutamate transmembrane import into vacuole](http://purl.obolibrary.org/obo/GO_0090515) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The directed movement of L-glutamate into the vacuole across the vacuolar membrane." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:al" -#### Added -- [Thy-1 membrane glycoprotein](http://purl.obolibrary.org/obo/PR_000001843) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [Thy-1 membrane glycoprotein (human)](http://purl.obolibrary.org/obo/PR_P04216) +- Class: [L-glutamate transmembrane import into vacuole](http://purl.obolibrary.org/obo/GO_0090515) +- [L-glutamate transmembrane import into vacuole](http://purl.obolibrary.org/obo/GO_0090515) EquivalentTo [acidic amino acid transport](http://purl.obolibrary.org/obo/GO_0015800) and ([has target start location](http://purl.obolibrary.org/obo/RO_0002338) some [cytosol](http://purl.obolibrary.org/obo/GO_0005829)) and ([has target end location](http://purl.obolibrary.org/obo/RO_0002339) some [vacuolar lumen](http://purl.obolibrary.org/obo/GO_0005775)) and ([results in transport across](http://purl.obolibrary.org/obo/RO_0002342) some [membrane](http://purl.obolibrary.org/obo/GO_0016020)) and ([has primary input](http://purl.obolibrary.org/obo/RO_0004009) some [CHEBI_29985](http://purl.obolibrary.org/obo/CHEBI_29985)) -### UBPROP_0000111 `http://purl.obolibrary.org/obo/UBPROP_0000111` +- [L-glutamate transmembrane import into vacuole](http://purl.obolibrary.org/obo/GO_0090515) SubClassOf [L-glutamate transmembrane transport](http://purl.obolibrary.org/obo/GO_0015813) -#### Added -- AnnotationProperty: [UBPROP_0000111](http://purl.obolibrary.org/obo/UBPROP_0000111) +- [L-glutamate transmembrane import into vacuole](http://purl.obolibrary.org/obo/GO_0090515) SubClassOf [amino acid transmembrane import into vacuole](http://purl.obolibrary.org/obo/GO_0032975) -### V(D)J recombination-activating protein 1 `http://purl.obolibrary.org/obo/PR_000003457` +### L-histidine import across plasma membrane `http://purl.obolibrary.org/obo/GO_1903810` #### Added -- [V(D)J recombination-activating protein 1](http://purl.obolibrary.org/obo/PR_000003457) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [V(D)J recombination-activating protein 1 (human)](http://purl.obolibrary.org/obo/PR_P15918) +- [L-histidine import across plasma membrane](http://purl.obolibrary.org/obo/GO_1903810) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "histidine import" +- [L-histidine import across plasma membrane](http://purl.obolibrary.org/obo/GO_1903810) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "dph" -### V(D)J recombination-activating protein 2 `http://purl.obolibrary.org/obo/PR_000003460` +- [L-histidine import across plasma membrane](http://purl.obolibrary.org/obo/GO_1903810) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "L-histidine import into cell" -#### Added -- [V(D)J recombination-activating protein 2](http://purl.obolibrary.org/obo/PR_000003460) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [V(D)J recombination-activating protein 2 (human)](http://purl.obolibrary.org/obo/PR_P55895) +- [L-histidine import across plasma membrane](http://purl.obolibrary.org/obo/GO_1903810) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The directed movement of L-histidine from outside of a cell, across the plasma membrane and into the cytosol." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:23895341" -### VIP peptides `http://purl.obolibrary.org/obo/PR_000017299` + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GO_REF:0000075" -#### Added -- [VIP peptides](http://purl.obolibrary.org/obo/PR_000017299) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [VIP peptides (human)](http://purl.obolibrary.org/obo/PR_P01282) +- [L-histidine import across plasma membrane](http://purl.obolibrary.org/obo/GO_1903810) [has_alternative_id](http://www.geneontology.org/formats/oboInOwl#hasAlternativeId) "GO:0090466" +- [L-histidine import across plasma membrane](http://purl.obolibrary.org/obo/GO_1903810) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:1903810" -### a mis-spelling that is in common use and thus recorded `http://purl.obolibrary.org/obo/uberon/core#MISSPELLING` +- [L-histidine import across plasma membrane](http://purl.obolibrary.org/obo/GO_1903810) [label](http://www.w3.org/2000/01/rdf-schema#label) "L-histidine import across plasma membrane" -#### Added -- [a mis-spelling that is in common use and thus recorded](http://purl.obolibrary.org/obo/uberon/core#MISSPELLING) [label](http://www.w3.org/2000/01/rdf-schema#label) "a mis-spelling that is in common use and thus recorded" +- [L-histidine import across plasma membrane](http://purl.obolibrary.org/obo/GO_1903810) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "L-histidine import" +- [L-histidine import across plasma membrane](http://purl.obolibrary.org/obo/GO_1903810) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" -### acropodial skeleton `http://purl.obolibrary.org/obo/UBERON_0010543` -#### Removed -- [acropodial skeleton](http://purl.obolibrary.org/obo/UBERON_0010543) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000) +- [L-histidine import across plasma membrane](http://purl.obolibrary.org/obo/GO_1903810) [has_alternative_id](http://www.geneontology.org/formats/oboInOwl#hasAlternativeId) "GO:0061460" +- [L-histidine import across plasma membrane](http://purl.obolibrary.org/obo/GO_1903810) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2012-10-05T10:20:50Z" +- Class: [L-histidine import across plasma membrane](http://purl.obolibrary.org/obo/GO_1903810) -### acropodium region `http://purl.obolibrary.org/obo/UBERON_0012354` -#### Removed -- [acropodium region](http://purl.obolibrary.org/obo/UBERON_0012354) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000) +- [L-histidine import across plasma membrane](http://purl.obolibrary.org/obo/GO_1903810) EquivalentTo [transport](http://purl.obolibrary.org/obo/GO_0006810) and ([has target start location](http://purl.obolibrary.org/obo/RO_0002338) some [extracellular region](http://purl.obolibrary.org/obo/GO_0005576)) and ([has target end location](http://purl.obolibrary.org/obo/RO_0002339) some [cytosol](http://purl.obolibrary.org/obo/GO_0005829)) and ([results in transport across](http://purl.obolibrary.org/obo/RO_0002342) some [plasma membrane](http://purl.obolibrary.org/obo/GO_0005886)) and ([has primary input](http://purl.obolibrary.org/obo/RO_0004009) some [CHEBI_57595](http://purl.obolibrary.org/obo/CHEBI_57595)) +- [L-histidine import across plasma membrane](http://purl.obolibrary.org/obo/GO_1903810) SubClassOf [import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098739) +- [L-histidine import across plasma membrane](http://purl.obolibrary.org/obo/GO_1903810) SubClassOf [L-histidine transmembrane transport](http://purl.obolibrary.org/obo/GO_0089709) -### acts on population of `http://purl.obolibrary.org/obo/RO_0012003` -#### Removed -- [acts on population of](http://purl.obolibrary.org/obo/RO_0012003) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "pg" + +### L-histidine transmembrane export from vacuole `http://purl.obolibrary.org/obo/GO_0089708` #### Added -- [acts on population of](http://purl.obolibrary.org/obo/RO_0012003) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) [0000-0003-1813-6857](https://orcid.org/0000-0003-1813-6857) +- [L-histidine transmembrane export from vacuole](http://purl.obolibrary.org/obo/GO_0089708) [label](http://www.w3.org/2000/01/rdf-schema#label) "L-histidine transmembrane export from vacuole" +- [L-histidine transmembrane export from vacuole](http://purl.obolibrary.org/obo/GO_0089708) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" -### acts upstream of or within `http://purl.obolibrary.org/obo/RO_0002264` -#### Removed -- [acts upstream of or within](http://purl.obolibrary.org/obo/RO_0002264) [see also](http://www.w3.org/2000/01/rdf-schema#seeAlso) [Acts_upstream_of_or_within](http://wiki.geneontology.org/index.php/Acts_upstream_of_or_within) +- [L-histidine transmembrane export from vacuole](http://purl.obolibrary.org/obo/GO_0089708) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0089708" -#### Added -- [acts upstream of or within](http://purl.obolibrary.org/obo/RO_0002264) [see also](http://www.w3.org/2000/01/rdf-schema#seeAlso) "https://wiki.geneontology.org/Acts_upstream_of_or_within"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI) +- [L-histidine transmembrane export from vacuole](http://purl.obolibrary.org/obo/GO_0089708) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The directed movement of L-histidine out of the vacuole, across the vacuolar membrane." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:21307582" +- Class: [L-histidine transmembrane export from vacuole](http://purl.obolibrary.org/obo/GO_0089708) -### acts upstream of or within, negative effect `http://purl.obolibrary.org/obo/RO_0004033` +- [L-histidine transmembrane export from vacuole](http://purl.obolibrary.org/obo/GO_0089708) EquivalentTo [basic amino acid transport](http://purl.obolibrary.org/obo/GO_0015802) and ([has target start location](http://purl.obolibrary.org/obo/RO_0002338) some [vacuolar lumen](http://purl.obolibrary.org/obo/GO_0005775)) and ([has target end location](http://purl.obolibrary.org/obo/RO_0002339) some [cytosol](http://purl.obolibrary.org/obo/GO_0005829)) and ([results in transport across](http://purl.obolibrary.org/obo/RO_0002342) some [membrane](http://purl.obolibrary.org/obo/GO_0016020)) and ([has primary input](http://purl.obolibrary.org/obo/RO_0004009) some [CHEBI_57595](http://purl.obolibrary.org/obo/CHEBI_57595)) -#### Added -- [acts upstream of or within, negative effect](http://purl.obolibrary.org/obo/RO_0004033) [see also](http://www.w3.org/2000/01/rdf-schema#seeAlso) "https://wiki.geneontology.org/Acts_upstream_of_or_within,_negative_effect"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI) +- [L-histidine transmembrane export from vacuole](http://purl.obolibrary.org/obo/GO_0089708) SubClassOf [amino acid transmembrane export from vacuole](http://purl.obolibrary.org/obo/GO_0032974) +- [L-histidine transmembrane export from vacuole](http://purl.obolibrary.org/obo/GO_0089708) SubClassOf [L-histidine transmembrane transport](http://purl.obolibrary.org/obo/GO_0089709) -### acts upstream of or within, positive effect `http://purl.obolibrary.org/obo/RO_0004032` -#### Removed -- [acts upstream of or within, positive effect](http://purl.obolibrary.org/obo/RO_0004032) [see also](http://www.w3.org/2000/01/rdf-schema#seeAlso) [_positive_effect](http://wiki.geneontology.org/index.php/Acts_upstream_of_or_within,_positive_effect) +- [L-histidine transmembrane export from vacuole](http://purl.obolibrary.org/obo/GO_0089708) SubClassOf [basic amino acid transmembrane transport](http://purl.obolibrary.org/obo/GO_1990822) -#### Added -- [acts upstream of or within, positive effect](http://purl.obolibrary.org/obo/RO_0004032) [see also](http://www.w3.org/2000/01/rdf-schema#seeAlso) "https://wiki.geneontology.org/Acts_upstream_of_or_within,_positive_effect"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI) +- [L-histidine transmembrane export from vacuole](http://purl.obolibrary.org/obo/GO_0089708) SubClassOf [L-histidine transport](http://purl.obolibrary.org/obo/GO_1902024) -### acts upstream of, negative effect `http://purl.obolibrary.org/obo/RO_0004035` -#### Removed -- [acts upstream of, negative effect](http://purl.obolibrary.org/obo/RO_0004035) [see also](http://www.w3.org/2000/01/rdf-schema#seeAlso) [_negative_effect](http://wiki.geneontology.org/index.php/Acts_upstream_of,_negative_effect) +### L-histidine transmembrane import into vacuole `http://purl.obolibrary.org/obo/GO_0090513` #### Added -- [acts upstream of, negative effect](http://purl.obolibrary.org/obo/RO_0004035) [see also](http://www.w3.org/2000/01/rdf-schema#seeAlso) "https://wiki.geneontology.org/Acts_upstream_of,_negative_effect"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI) +- [L-histidine transmembrane import into vacuole](http://purl.obolibrary.org/obo/GO_0090513) [label](http://www.w3.org/2000/01/rdf-schema#label) "L-histidine transmembrane import into vacuole" +- [L-histidine transmembrane import into vacuole](http://purl.obolibrary.org/obo/GO_0090513) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "vacuolar histidine import" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:tb" -### acts upstream of, positive effect `http://purl.obolibrary.org/obo/RO_0004034` -#### Removed -- [acts upstream of, positive effect](http://purl.obolibrary.org/obo/RO_0004034) [see also](http://www.w3.org/2000/01/rdf-schema#seeAlso) [_positive_effect](http://wiki.geneontology.org/index.php/Acts_upstream_of,_positive_effect) +- [L-histidine transmembrane import into vacuole](http://purl.obolibrary.org/obo/GO_0090513) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2012-12-14T11:25:52Z" -#### Added -- [acts upstream of, positive effect](http://purl.obolibrary.org/obo/RO_0004034) [see also](http://www.w3.org/2000/01/rdf-schema#seeAlso) "https://wiki.geneontology.org/Acts_upstream_of,_positive_effect"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI) +- [L-histidine transmembrane import into vacuole](http://purl.obolibrary.org/obo/GO_0090513) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "histidine transmembrane import into vacuole" +- [L-histidine transmembrane import into vacuole](http://purl.obolibrary.org/obo/GO_0090513) [has_alternative_id](http://www.geneontology.org/formats/oboInOwl#hasAlternativeId) "GO:0090457" -### adenohypophyseal placode `http://purl.obolibrary.org/obo/UBERON_0009122` -#### Removed -- [adenohypophyseal placode](http://purl.obolibrary.org/obo/UBERON_0009122) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [L-histidine transmembrane import into vacuole](http://purl.obolibrary.org/obo/GO_0090513) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The directed movement of L-histidine into the vacuole across the vacuolar membrane." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:al" +- [L-histidine transmembrane import into vacuole](http://purl.obolibrary.org/obo/GO_0090513) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "tb" +- [L-histidine transmembrane import into vacuole](http://purl.obolibrary.org/obo/GO_0090513) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0090513" -### adhesion G protein-coupled receptor E1 `http://purl.obolibrary.org/obo/PR_000001813` +- [L-histidine transmembrane import into vacuole](http://purl.obolibrary.org/obo/GO_0090513) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" -#### Added -- [adhesion G protein-coupled receptor E1](http://purl.obolibrary.org/obo/PR_000001813) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [adhesion G protein-coupled receptor E1 (human)](http://purl.obolibrary.org/obo/PR_Q14246) +- Class: [L-histidine transmembrane import into vacuole](http://purl.obolibrary.org/obo/GO_0090513) +- [L-histidine transmembrane import into vacuole](http://purl.obolibrary.org/obo/GO_0090513) EquivalentTo [basic amino acid transport](http://purl.obolibrary.org/obo/GO_0015802) and ([has target start location](http://purl.obolibrary.org/obo/RO_0002338) some [cytosol](http://purl.obolibrary.org/obo/GO_0005829)) and ([has target end location](http://purl.obolibrary.org/obo/RO_0002339) some [vacuolar lumen](http://purl.obolibrary.org/obo/GO_0005775)) and ([results in transport across](http://purl.obolibrary.org/obo/RO_0002342) some [membrane](http://purl.obolibrary.org/obo/GO_0016020)) and ([has primary input](http://purl.obolibrary.org/obo/RO_0004009) some [CHEBI_57595](http://purl.obolibrary.org/obo/CHEBI_57595)) -### adipose macrophage `http://purl.obolibrary.org/obo/CL_0002477` -#### Removed -- [adipose macrophage](http://purl.obolibrary.org/obo/CL_0002477) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [L-histidine transmembrane import into vacuole](http://purl.obolibrary.org/obo/GO_0090513) SubClassOf [basic amino acid transmembrane import into vacuole](http://purl.obolibrary.org/obo/GO_0034490) + +- [L-histidine transmembrane import into vacuole](http://purl.obolibrary.org/obo/GO_0090513) SubClassOf [L-histidine transport](http://purl.obolibrary.org/obo/GO_1902024) +- [L-histidine transmembrane import into vacuole](http://purl.obolibrary.org/obo/GO_0090513) SubClassOf [L-histidine transmembrane transport](http://purl.obolibrary.org/obo/GO_0089709) -### adipose tissue `http://purl.obolibrary.org/obo/UBERON_0001013` +### L5 extratelencephalic projecting glutamatergic cortical neuron `http://purl.obolibrary.org/obo/CL_4023041` #### Removed -- [adipose tissue](http://purl.obolibrary.org/obo/UBERON_0001013) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [L5 extratelencephalic projecting glutamatergic cortical neuron](http://purl.obolibrary.org/obo/CL_4023041) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "L5b neuron" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "DOI:10.1016/j.neuron.2011.07.029" + +#### Added +- [L5 extratelencephalic projecting glutamatergic cortical neuron](http://purl.obolibrary.org/obo/CL_4023041) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "L5b neuron" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "DOI:10.1016/j.neuron.2011.07.029" + - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation) -### aggregate regional part of brain `http://purl.obolibrary.org/obo/UBERON_0010009` +### Mullerian duct regression `http://purl.obolibrary.org/obo/GO_0001880` #### Removed -- [aggregate regional part of brain](http://purl.obolibrary.org/obo/UBERON_0010009) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [Mullerian duct regression](http://purl.obolibrary.org/obo/GO_0001880) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" +- [Mullerian duct regression](http://purl.obolibrary.org/obo/GO_0001880) [label](http://www.w3.org/2000/01/rdf-schema#label) "Mullerian duct regression" +- [Mullerian duct regression](http://purl.obolibrary.org/obo/GO_0001880) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The process in which the Mullerian ducts, primordia of the oviducts, uterus and upper vagina, undergo regression in male embryos." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dph" -### allantois `http://purl.obolibrary.org/obo/UBERON_0004340` -#### Removed -- [allantois](http://purl.obolibrary.org/obo/UBERON_0004340) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:12368913" +- [Mullerian duct regression](http://purl.obolibrary.org/obo/GO_0001880) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0001880" +- Class: [Mullerian duct regression](http://purl.obolibrary.org/obo/GO_0001880) -### alpha-(1,3)-fucosyltransferase 4 `http://purl.obolibrary.org/obo/PR_000001456` +- [Mullerian duct regression](http://purl.obolibrary.org/obo/GO_0001880) EquivalentTo [anatomical structure regression](http://purl.obolibrary.org/obo/GO_0060033) and ([has input](http://purl.obolibrary.org/obo/RO_0002233) some [Mullerian duct](http://purl.obolibrary.org/obo/UBERON_0003890)) -#### Added -- [alpha-(1,3)-fucosyltransferase 4](http://purl.obolibrary.org/obo/PR_000001456) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [alpha-(1,3)-fucosyltransferase 4 (human)](http://purl.obolibrary.org/obo/PR_P22083) +- [Mullerian duct regression](http://purl.obolibrary.org/obo/GO_0001880) SubClassOf [has input](http://purl.obolibrary.org/obo/RO_0002233) some [Mullerian duct](http://purl.obolibrary.org/obo/UBERON_0003890) +- [Mullerian duct regression](http://purl.obolibrary.org/obo/GO_0001880) SubClassOf [developmental process involved in reproduction](http://purl.obolibrary.org/obo/GO_0003006) -### alpha-beta T cell `http://purl.obolibrary.org/obo/CL_0000789` -#### Removed -- [alpha-beta T cell](http://purl.obolibrary.org/obo/CL_0000789) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [Mullerian duct regression](http://purl.obolibrary.org/obo/GO_0001880) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [male sex differentiation](http://purl.obolibrary.org/obo/GO_0046661) +- [Mullerian duct regression](http://purl.obolibrary.org/obo/GO_0001880) SubClassOf [anatomical structure regression](http://purl.obolibrary.org/obo/GO_0060033) -### alpha7 GABAergic cortical interneuron (Mmus) `http://purl.obolibrary.org/obo/CL_4023010` + +### OFF midget ganglion cell `http://purl.obolibrary.org/obo/CL_4033047` #### Added -- [alpha7 GABAergic cortical interneuron (Mmus)](http://purl.obolibrary.org/obo/CL_4023010) [symbol](http://purl.obolibrary.org/obo/IAO_0000028) "A7 interneuron" +- [OFF midget ganglion cell](http://purl.obolibrary.org/obo/CL_4033047) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "OFF-midget RGC" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:34093409" +- [OFF midget ganglion cell](http://purl.obolibrary.org/obo/CL_4033047) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "outer stratifying midget cell" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:32032773" -### alveolar macrophage `http://purl.obolibrary.org/obo/CL_0000583` -#### Removed -- [alveolar macrophage](http://purl.obolibrary.org/obo/CL_0000583) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [OFF midget ganglion cell](http://purl.obolibrary.org/obo/CL_4033047) [contributor](http://purl.org/dc/terms/contributor) [0000-0001-6677-8489](https://orcid.org/0000-0001-6677-8489) +- [OFF midget ganglion cell](http://purl.obolibrary.org/obo/CL_4033047) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A midget ganglion cell that depolarizes in response to decreased light intensity in the center of its receptive field. The majority of input that this cell receives comes from flat midget bipolar cells." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:32032773" +- [OFF midget ganglion cell](http://purl.obolibrary.org/obo/CL_4033047) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "OFF-midget cell" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:34093409" -### amacrine cell `http://purl.obolibrary.org/obo/CL_0000561` -#### Removed -- [amacrine cell](http://purl.obolibrary.org/obo/CL_0000561) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [OFF midget ganglion cell](http://purl.obolibrary.org/obo/CL_4033047) [label](http://www.w3.org/2000/01/rdf-schema#label) "OFF midget ganglion cell" -#### Added -- [amacrine cell](http://purl.obolibrary.org/obo/CL_0000561) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "AC" - - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation) +- [OFF midget ganglion cell](http://purl.obolibrary.org/obo/CL_4033047) [date](http://purl.org/dc/terms/date) "2023-08-08T11:05:37Z"^^[dateTime](http://www.w3.org/2001/XMLSchema#dateTime) - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1038/s41598-020-66092-9" +- Class: [OFF midget ganglion cell](http://purl.obolibrary.org/obo/CL_4033047) -- [amacrine cell](http://purl.obolibrary.org/obo/CL_0000561) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "ACs" - - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation) +- [OFF midget ganglion cell](http://purl.obolibrary.org/obo/CL_4033047) EquivalentTo [OFF retinal ganglion cell](http://purl.obolibrary.org/obo/CL_4023033) and [midget ganglion cell of retina](http://purl.obolibrary.org/obo/CL_4023188) - - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [plural term](http://purl.obolibrary.org/obo/uberon#PLURAL) +- [OFF midget ganglion cell](http://purl.obolibrary.org/obo/CL_4033047) SubClassOf [OFF retinal ganglion cell](http://purl.obolibrary.org/obo/CL_4023033) - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1038/s41598-020-66092-9" +- [OFF midget ganglion cell](http://purl.obolibrary.org/obo/CL_4033047) SubClassOf [midget ganglion cell of retina](http://purl.obolibrary.org/obo/CL_4023188) -### aminopeptidase N `http://purl.obolibrary.org/obo/PR_000002031` +### OFF parasol ganglion cell `http://purl.obolibrary.org/obo/CL_4033051` #### Added -- [aminopeptidase N](http://purl.obolibrary.org/obo/PR_000002031) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [aminopeptidase N (human)](http://purl.obolibrary.org/obo/PR_P15144) +- [OFF parasol ganglion cell](http://purl.obolibrary.org/obo/CL_4033051) [date](http://purl.org/dc/terms/date) "2023-08-08T12:34:57Z"^^[dateTime](http://www.w3.org/2001/XMLSchema#dateTime) +- [OFF parasol ganglion cell](http://purl.obolibrary.org/obo/CL_4033051) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "outer parasol cell" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:32032773" -### amnion `http://purl.obolibrary.org/obo/UBERON_0000305` -#### Removed -- [amnion](http://purl.obolibrary.org/obo/UBERON_0000305) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [OFF parasol ganglion cell](http://purl.obolibrary.org/obo/CL_4033051) [label](http://www.w3.org/2000/01/rdf-schema#label) "OFF parasol ganglion cell" +- [OFF parasol ganglion cell](http://purl.obolibrary.org/obo/CL_4033051) [contributor](http://purl.org/dc/terms/contributor) [0000-0001-6677-8489](https://orcid.org/0000-0001-6677-8489) +- [OFF parasol ganglion cell](http://purl.obolibrary.org/obo/CL_4033051) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "OFF-parasol RGC" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:34093409" -### amniotic ectoderm `http://purl.obolibrary.org/obo/UBERON_0003254` -#### Removed -- [amniotic ectoderm](http://purl.obolibrary.org/obo/UBERON_0003254) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [OFF parasol ganglion cell](http://purl.obolibrary.org/obo/CL_4033051) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A parasol ganglion cell that depolarizes in response to decreased light intensity in the center of its receptive field. The majority of input that this cell receives comes from DB3a bipolar cells." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:32032773" +- [OFF parasol ganglion cell](http://purl.obolibrary.org/obo/CL_4033051) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "OFF-parasol retinal ganglion cell" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:34093409" +- Class: [OFF parasol ganglion cell](http://purl.obolibrary.org/obo/CL_4033051) -### amniotic fold `http://purl.obolibrary.org/obo/UBERON_0005971` -#### Removed -- [amniotic fold](http://purl.obolibrary.org/obo/UBERON_0005971) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [OFF parasol ganglion cell](http://purl.obolibrary.org/obo/CL_4033051) EquivalentTo [OFF retinal ganglion cell](http://purl.obolibrary.org/obo/CL_4023033) and [parasol ganglion cell of retina](http://purl.obolibrary.org/obo/CL_4023189) + +- [OFF parasol ganglion cell](http://purl.obolibrary.org/obo/CL_4033051) SubClassOf [parasol ganglion cell of retina](http://purl.obolibrary.org/obo/CL_4023189) +- [OFF parasol ganglion cell](http://purl.obolibrary.org/obo/CL_4033051) SubClassOf [OFF retinal ganglion cell](http://purl.obolibrary.org/obo/CL_4023033) -### amygdala excitatory neuron `http://purl.obolibrary.org/obo/CL_4023039` +### OMO_0001000 `http://purl.obolibrary.org/obo/OMO_0001000` #### Removed -- [amygdala excitatory neuron](http://purl.obolibrary.org/obo/CL_4023039) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- Individual: [OMO_0001000](http://purl.obolibrary.org/obo/OMO_0001000) -### amygdala pyramidal neuron `http://purl.obolibrary.org/obo/CL_4023110` -#### Removed -- [amygdala pyramidal neuron](http://purl.obolibrary.org/obo/CL_4023110) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +### ON midget ganglion cell `http://purl.obolibrary.org/obo/CL_4033046` +#### Added +- [ON midget ganglion cell](http://purl.obolibrary.org/obo/CL_4033046) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "ON-midget cell" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:34093409" +- [ON midget ganglion cell](http://purl.obolibrary.org/obo/CL_4033046) [label](http://www.w3.org/2000/01/rdf-schema#label) "ON midget ganglion cell" -### anal canal `http://purl.obolibrary.org/obo/UBERON_0000159` -#### Removed -- [anal canal](http://purl.obolibrary.org/obo/UBERON_0000159) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [ON midget ganglion cell](http://purl.obolibrary.org/obo/CL_4033046) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A midget ganglion cell that depolarizes in response to increased light intensity in the center of its receptive field. The majority of input that this cell receives comes from invaginating midget bipolar cells." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:32032773" +- [ON midget ganglion cell](http://purl.obolibrary.org/obo/CL_4033046) [date](http://purl.org/dc/terms/date) "2023-08-08T09:40:08Z"^^[dateTime](http://www.w3.org/2001/XMLSchema#dateTime) +- [ON midget ganglion cell](http://purl.obolibrary.org/obo/CL_4033046) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "ON-midget RGC" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:34093409" -### anal region `http://purl.obolibrary.org/obo/UBERON_0001353` -#### Removed -- [anal region](http://purl.obolibrary.org/obo/UBERON_0001353) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [ON midget ganglion cell](http://purl.obolibrary.org/obo/CL_4033046) [contributor](http://purl.org/dc/terms/contributor) [0000-0001-6677-8489](https://orcid.org/0000-0001-6677-8489) +- [ON midget ganglion cell](http://purl.obolibrary.org/obo/CL_4033046) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "inner stratifying midget cell" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:32032773" +- Class: [ON midget ganglion cell](http://purl.obolibrary.org/obo/CL_4033046) -### angioblastic mesenchymal cell `http://purl.obolibrary.org/obo/CL_0000566` -#### Removed -- [angioblastic mesenchymal cell](http://purl.obolibrary.org/obo/CL_0000566) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [ON midget ganglion cell](http://purl.obolibrary.org/obo/CL_4033046) EquivalentTo [ON retinal ganglion cell](http://purl.obolibrary.org/obo/CL_4023032) and [midget ganglion cell of retina](http://purl.obolibrary.org/obo/CL_4023188) +- [ON midget ganglion cell](http://purl.obolibrary.org/obo/CL_4033046) SubClassOf [midget ganglion cell of retina](http://purl.obolibrary.org/obo/CL_4023188) +- [ON midget ganglion cell](http://purl.obolibrary.org/obo/CL_4033046) SubClassOf [ON retinal ganglion cell](http://purl.obolibrary.org/obo/CL_4023032) -### anorectum `http://purl.obolibrary.org/obo/UBERON_8410050` -#### Removed -- [anorectum](http://purl.obolibrary.org/obo/UBERON_8410050) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +### ON parasol ganglion cell `http://purl.obolibrary.org/obo/CL_4033052` +#### Added +- [ON parasol ganglion cell](http://purl.obolibrary.org/obo/CL_4033052) [contributor](http://purl.org/dc/terms/contributor) [0000-0001-6677-8489](https://orcid.org/0000-0001-6677-8489) -### anterior limiting lamina of cornea `http://purl.obolibrary.org/obo/UBERON_0004370` -#### Removed -- [anterior limiting lamina of cornea](http://purl.obolibrary.org/obo/UBERON_0004370) SubClassOf [connected anatomical structure](http://purl.obolibrary.org/obo/CARO_0000003) +- [ON parasol ganglion cell](http://purl.obolibrary.org/obo/CL_4033052) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A parasol ganglion cell that depolarizes in response to increased light intensity in the center of its receptive field. The majority of input that this cell receives comes from DB4 bipolar cells." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:32032773" +- [ON parasol ganglion cell](http://purl.obolibrary.org/obo/CL_4033052) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "ON-parasol retinal ganglion cell" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:34093409" +- [ON parasol ganglion cell](http://purl.obolibrary.org/obo/CL_4033052) [label](http://www.w3.org/2000/01/rdf-schema#label) "ON parasol ganglion cell" -### anterior neural tube `http://purl.obolibrary.org/obo/UBERON_0003080` -#### Removed -- [anterior neural tube](http://purl.obolibrary.org/obo/UBERON_0003080) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [ON parasol ganglion cell](http://purl.obolibrary.org/obo/CL_4033052) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "inner parasol cell" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:32032773" +- [ON parasol ganglion cell](http://purl.obolibrary.org/obo/CL_4033052) [date](http://purl.org/dc/terms/date) "2023-08-08T12:39:35Z"^^[dateTime](http://www.w3.org/2001/XMLSchema#dateTime) +- [ON parasol ganglion cell](http://purl.obolibrary.org/obo/CL_4033052) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "ON-parasol RGC" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:34093409" -### anterior part of tongue `http://purl.obolibrary.org/obo/UBERON_0010032` -#### Removed -- [anterior part of tongue](http://purl.obolibrary.org/obo/UBERON_0010032) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- Class: [ON parasol ganglion cell](http://purl.obolibrary.org/obo/CL_4033052) +- [ON parasol ganglion cell](http://purl.obolibrary.org/obo/CL_4033052) EquivalentTo [ON retinal ganglion cell](http://purl.obolibrary.org/obo/CL_4023032) and [parasol ganglion cell of retina](http://purl.obolibrary.org/obo/CL_4023189) +- [ON parasol ganglion cell](http://purl.obolibrary.org/obo/CL_4033052) SubClassOf [parasol ganglion cell of retina](http://purl.obolibrary.org/obo/CL_4023189) -### anterior uvea `http://purl.obolibrary.org/obo/UBERON_0011892` -#### Removed -- [anterior uvea](http://purl.obolibrary.org/obo/UBERON_0011892) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [ON parasol ganglion cell](http://purl.obolibrary.org/obo/CL_4033052) SubClassOf [ON retinal ganglion cell](http://purl.obolibrary.org/obo/CL_4023032) +### RNA biosynthetic process `http://purl.obolibrary.org/obo/GO_0032774` +#### Removed +- [RNA biosynthetic process](http://purl.obolibrary.org/obo/GO_0032774) EquivalentTo [biosynthetic process](http://purl.obolibrary.org/obo/GO_0009058) and ([has primary output](http://purl.obolibrary.org/obo/RO_0004008) some [CHEBI_33697](http://purl.obolibrary.org/obo/CHEBI_33697)) -### antigen-presenting glycoprotein CD1d `http://purl.obolibrary.org/obo/PR_000002028` +- [RNA biosynthetic process](http://purl.obolibrary.org/obo/GO_0032774) SubClassOf [biosynthetic process](http://purl.obolibrary.org/obo/GO_0009058) #### Added -- [antigen-presenting glycoprotein CD1d](http://purl.obolibrary.org/obo/PR_000002028) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [antigen-presenting glycoprotein CD1d (human)](http://purl.obolibrary.org/obo/PR_P15813) +- [RNA biosynthetic process](http://purl.obolibrary.org/obo/GO_0032774) EquivalentTo [macromolecule biosynthetic process](http://purl.obolibrary.org/obo/GO_0009059) and ([has primary output](http://purl.obolibrary.org/obo/RO_0004008) some [CHEBI_33697](http://purl.obolibrary.org/obo/CHEBI_33697)) +- [RNA biosynthetic process](http://purl.obolibrary.org/obo/GO_0032774) SubClassOf [macromolecule biosynthetic process](http://purl.obolibrary.org/obo/GO_0009059) -### aortico-pulmonary spiral septum `http://purl.obolibrary.org/obo/UBERON_0006207` -#### Removed -- [aortico-pulmonary spiral septum](http://purl.obolibrary.org/obo/UBERON_0006207) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +### RNA export from nucleus `http://purl.obolibrary.org/obo/GO_0006405` +#### Added +- [RNA export from nucleus](http://purl.obolibrary.org/obo/GO_0006405) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "RNA-nucleus export" -### apical ectodermal ridge `http://purl.obolibrary.org/obo/UBERON_0004356` -#### Removed -- [apical ectodermal ridge](http://purl.obolibrary.org/obo/UBERON_0004356) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [RNA export from nucleus](http://purl.obolibrary.org/obo/GO_0006405) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" +- [RNA export from nucleus](http://purl.obolibrary.org/obo/GO_0006405) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "RNA export from cell nucleus" +- [RNA export from nucleus](http://purl.obolibrary.org/obo/GO_0006405) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "RNA export out of nucleus" -### aponeurosis `http://purl.obolibrary.org/obo/UBERON_0006614` -#### Removed -- [aponeurosis](http://purl.obolibrary.org/obo/UBERON_0006614) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [RNA export from nucleus](http://purl.obolibrary.org/obo/GO_0006405) [label](http://www.w3.org/2000/01/rdf-schema#label) "RNA export from nucleus" +- [RNA export from nucleus](http://purl.obolibrary.org/obo/GO_0006405) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "RNA transport from nucleus to cytoplasm" +- [RNA export from nucleus](http://purl.obolibrary.org/obo/GO_0006405) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0006405" -### appendage girdle region `http://purl.obolibrary.org/obo/UBERON_0007823` -#### Removed -- [appendage girdle region](http://purl.obolibrary.org/obo/UBERON_0007823) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000) +- [RNA export from nucleus](http://purl.obolibrary.org/obo/GO_0006405) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The directed movement of RNA from the nucleus to the cytoplasm." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:ma" +- Class: [RNA export from nucleus](http://purl.obolibrary.org/obo/GO_0006405) +- [RNA export from nucleus](http://purl.obolibrary.org/obo/GO_0006405) EquivalentTo [transport](http://purl.obolibrary.org/obo/GO_0006810) and ([has target start location](http://purl.obolibrary.org/obo/RO_0002338) some [nuclear lumen](http://purl.obolibrary.org/obo/GO_0031981)) and ([has target end location](http://purl.obolibrary.org/obo/RO_0002339) some [cytosol](http://purl.obolibrary.org/obo/GO_0005829)) and ([results in transport across](http://purl.obolibrary.org/obo/RO_0002342) some [nuclear envelope](http://purl.obolibrary.org/obo/GO_0005635)) and ([has primary input](http://purl.obolibrary.org/obo/RO_0004009) some [CHEBI_33697](http://purl.obolibrary.org/obo/CHEBI_33697)) -### arch of aorta `http://purl.obolibrary.org/obo/UBERON_0001508` -#### Removed -- [arch of aorta](http://purl.obolibrary.org/obo/UBERON_0001508) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [RNA export from nucleus](http://purl.obolibrary.org/obo/GO_0006405) SubClassOf [nuclear export](http://purl.obolibrary.org/obo/GO_0051168) +- [RNA export from nucleus](http://purl.obolibrary.org/obo/GO_0006405) SubClassOf [RNA transport](http://purl.obolibrary.org/obo/GO_0050658) -### areolar connective tissue `http://purl.obolibrary.org/obo/UBERON_0006815` -#### Removed -- [areolar connective tissue](http://purl.obolibrary.org/obo/UBERON_0006815) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +### RNA import into nucleus `http://purl.obolibrary.org/obo/GO_0006404` +#### Added +- [RNA import into nucleus](http://purl.obolibrary.org/obo/GO_0006404) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" +- [RNA import into nucleus](http://purl.obolibrary.org/obo/GO_0006404) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "RNA transport from cytoplasm to nucleus" -### arginase-1 `http://purl.obolibrary.org/obo/PR_000001844` +- [RNA import into nucleus](http://purl.obolibrary.org/obo/GO_0006404) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The import of RNA from the cytoplasm to the nucleus." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:ma" -#### Added -- [arginase-1](http://purl.obolibrary.org/obo/PR_000001844) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [arginase-1 (human)](http://purl.obolibrary.org/obo/PR_P05089) +- [RNA import into nucleus](http://purl.obolibrary.org/obo/GO_0006404) [label](http://www.w3.org/2000/01/rdf-schema#label) "RNA import into nucleus" +- [RNA import into nucleus](http://purl.obolibrary.org/obo/GO_0006404) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "RNA import into cell nucleus" -### arrector muscle of hair `http://purl.obolibrary.org/obo/UBERON_0002033` -#### Removed -- [arrector muscle of hair](http://purl.obolibrary.org/obo/UBERON_0002033) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000) +- [RNA import into nucleus](http://purl.obolibrary.org/obo/GO_0006404) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "RNA-nucleus import" +- [RNA import into nucleus](http://purl.obolibrary.org/obo/GO_0006404) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0006404" +- Class: [RNA import into nucleus](http://purl.obolibrary.org/obo/GO_0006404) -### arterial system `http://purl.obolibrary.org/obo/UBERON_0004572` -#### Removed -- [arterial system](http://purl.obolibrary.org/obo/UBERON_0004572) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [RNA import into nucleus](http://purl.obolibrary.org/obo/GO_0006404) EquivalentTo [transport](http://purl.obolibrary.org/obo/GO_0006810) and ([has target start location](http://purl.obolibrary.org/obo/RO_0002338) some [cytosol](http://purl.obolibrary.org/obo/GO_0005829)) and ([has target end location](http://purl.obolibrary.org/obo/RO_0002339) some [nuclear lumen](http://purl.obolibrary.org/obo/GO_0031981)) and ([results in transport across](http://purl.obolibrary.org/obo/RO_0002342) some [nuclear envelope](http://purl.obolibrary.org/obo/GO_0005635)) and ([has primary input](http://purl.obolibrary.org/obo/RO_0004009) some [CHEBI_33697](http://purl.obolibrary.org/obo/CHEBI_33697)) + +- [RNA import into nucleus](http://purl.obolibrary.org/obo/GO_0006404) SubClassOf [RNA transport](http://purl.obolibrary.org/obo/GO_0050658) +- [RNA import into nucleus](http://purl.obolibrary.org/obo/GO_0006404) SubClassOf [import into nucleus](http://purl.obolibrary.org/obo/GO_0051170) -### ascending aorta `http://purl.obolibrary.org/obo/UBERON_0001496` +### WF1 amacrine cell `http://purl.obolibrary.org/obo/CL_0004240` #### Removed -- [ascending aorta](http://purl.obolibrary.org/obo/UBERON_0001496) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [WF1 amacrine cell](http://purl.obolibrary.org/obo/CL_0004240) SubClassOf [retina horizontal cell](http://purl.obolibrary.org/obo/CL_0000745) -### ascending colon `http://purl.obolibrary.org/obo/UBERON_0001156` +### WF2 amacrine cell `http://purl.obolibrary.org/obo/CL_0004241` #### Removed -- [ascending colon](http://purl.obolibrary.org/obo/UBERON_0001156) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [WF2 amacrine cell](http://purl.obolibrary.org/obo/CL_0004241) SubClassOf [retina horizontal cell](http://purl.obolibrary.org/obo/CL_0000745) -### attached to part of `http://purl.obolibrary.org/obo/RO_0002177` +### WF3-1 amacrine cell `http://purl.obolibrary.org/obo/CL_0004242` #### Removed -- [attached to part of](http://purl.obolibrary.org/obo/RO_0002177) Domain [connected anatomical structure](http://purl.obolibrary.org/obo/CARO_0000003) - -- [attached to part of](http://purl.obolibrary.org/obo/RO_0002177) Range [connected anatomical structure](http://purl.obolibrary.org/obo/CARO_0000003) - -#### Added -- [attached to part of](http://purl.obolibrary.org/obo/RO_0002177) Domain [anatomical structure](http://purl.obolibrary.org/obo/UBERON_0000061) +- [WF3-1 amacrine cell](http://purl.obolibrary.org/obo/CL_0004242) SubClassOf [retina horizontal cell](http://purl.obolibrary.org/obo/CL_0000745) -- [attached to part of](http://purl.obolibrary.org/obo/RO_0002177) Range [anatomical structure](http://purl.obolibrary.org/obo/UBERON_0000061) -### auditory hillocks, pharyngeal arch 1 derived `http://purl.obolibrary.org/obo/UBERON_0016611` +### WF3-2 amacrine cell `http://purl.obolibrary.org/obo/CL_0004243` #### Removed -- [auditory hillocks, pharyngeal arch 1 derived](http://purl.obolibrary.org/obo/UBERON_0016611) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [WF3-2 amacrine cell](http://purl.obolibrary.org/obo/CL_0004243) SubClassOf [retina horizontal cell](http://purl.obolibrary.org/obo/CL_0000745) -### auditory hillocks, pharyngeal arch 2 derived `http://purl.obolibrary.org/obo/UBERON_0016612` +### WF4 amacrine cell `http://purl.obolibrary.org/obo/CL_0004244` #### Removed -- [auditory hillocks, pharyngeal arch 2 derived](http://purl.obolibrary.org/obo/UBERON_0016612) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [WF4 amacrine cell](http://purl.obolibrary.org/obo/CL_0004244) SubClassOf [retina horizontal cell](http://purl.obolibrary.org/obo/CL_0000745) -### auditory meatus epithelium `http://purl.obolibrary.org/obo/UBERON_0010065` +### acid secreting cell `http://purl.obolibrary.org/obo/CL_0000161` #### Removed -- [auditory meatus epithelium](http://purl.obolibrary.org/obo/UBERON_0010065) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [acid secreting cell](http://purl.obolibrary.org/obo/CL_0000161) [label](http://www.w3.org/2000/01/rdf-schema#label) "acid secreting cell" +- [acid secreting cell](http://purl.obolibrary.org/obo/CL_0000161) EquivalentTo [secretory cell](http://purl.obolibrary.org/obo/CL_0000151) and ([capable of](http://purl.obolibrary.org/obo/RO_0002215) some [acid secretion](http://purl.obolibrary.org/obo/GO_0046717)) +- [acid secreting cell](http://purl.obolibrary.org/obo/CL_0000161) SubClassOf [secretory cell](http://purl.obolibrary.org/obo/CL_0000151) + - [is_inferred](http://www.geneontology.org/formats/oboInOwl#is_inferred) "true" -### autonomic neuron `http://purl.obolibrary.org/obo/CL_0000107` -#### Removed -- [autonomic neuron](http://purl.obolibrary.org/obo/CL_0000107) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [acid secreting cell](http://purl.obolibrary.org/obo/CL_0000161) SubClassOf [capable of](http://purl.obolibrary.org/obo/RO_0002215) some [acid secretion](http://purl.obolibrary.org/obo/GO_0046717) +#### Added +- [acid secreting cell](http://purl.obolibrary.org/obo/CL_0000161) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "https://github.com/obophenotype/cell-ontology/issues/427" +- [acid secreting cell](http://purl.obolibrary.org/obo/CL_0000161) [consider](http://www.geneontology.org/formats/oboInOwl#consider) [parietal cell](http://purl.obolibrary.org/obo/CL_0000162) -### autopod region `http://purl.obolibrary.org/obo/UBERON_0002470` -#### Removed -- [autopod region](http://purl.obolibrary.org/obo/UBERON_0002470) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000) +- [acid secreting cell](http://purl.obolibrary.org/obo/CL_0000161) [label](http://www.w3.org/2000/01/rdf-schema#label) "obsolete acid secreting cell" +- [acid secreting cell](http://purl.obolibrary.org/obo/CL_0000161) [deprecated](http://www.w3.org/2002/07/owl#deprecated) true -### autopodial skeleton `http://purl.obolibrary.org/obo/UBERON_0006717` +### acyltransferase activity `http://purl.obolibrary.org/obo/GO_0016746` #### Removed -- [autopodial skeleton](http://purl.obolibrary.org/obo/UBERON_0006717) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000) - +- [acyltransferase activity](http://purl.obolibrary.org/obo/GO_0016746) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "EC:2.3.-.-" +- [acyltransferase activity](http://purl.obolibrary.org/obo/GO_0016746) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [goslim_chembl](http://purl.obolibrary.org/obo/go#goslim_chembl) -### axial mesoderm `http://purl.obolibrary.org/obo/UBERON_0003068` -#### Removed -- [axial mesoderm](http://purl.obolibrary.org/obo/UBERON_0003068) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [acyltransferase activity](http://purl.obolibrary.org/obo/GO_0016746) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-159431" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine" +- [acyltransferase activity](http://purl.obolibrary.org/obo/GO_0016746) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "molecular_function" +- [acyltransferase activity](http://purl.obolibrary.org/obo/GO_0016746) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-8858298" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "HRASLS transfer acyl group from PC to PE to form NAPE" -### axial musculature `http://purl.obolibrary.org/obo/UBERON_0013700` -#### Removed -- [axial musculature](http://purl.obolibrary.org/obo/UBERON_0013700) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000) +- [acyltransferase activity](http://purl.obolibrary.org/obo/GO_0016746) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:jl" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ISBN:0198506732" +- [acyltransferase activity](http://purl.obolibrary.org/obo/GO_0016746) [term tracker item](http://purl.obolibrary.org/obo/IAO_0000233) "https://github.com/geneontology/go-ontology/issues/20486"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI) -### axial skeletal system `http://purl.obolibrary.org/obo/UBERON_0011137` -#### Removed -- [axial skeletal system](http://purl.obolibrary.org/obo/UBERON_0011137) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [acyltransferase activity](http://purl.obolibrary.org/obo/GO_0016746) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0016746" +- [acyltransferase activity](http://purl.obolibrary.org/obo/GO_0016746) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-193491" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Chenodeoxycholoyl CoA reacts with glycine or taurine to form glycochenodeoxycholate or taurochenodeoxycholate" +- [acyltransferase activity](http://purl.obolibrary.org/obo/GO_0016746) [label](http://www.w3.org/2000/01/rdf-schema#label) "acyltransferase activity" -### axial skeleton plus cranial skeleton `http://purl.obolibrary.org/obo/UBERON_0005944` -#### Removed -- [axial skeleton plus cranial skeleton](http://purl.obolibrary.org/obo/UBERON_0005944) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [acyltransferase activity](http://purl.obolibrary.org/obo/GO_0016746) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-192312" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Choloyl CoA reacts with glycine or taurine to form glycocholate or taurocholate" +- [acyltransferase activity](http://purl.obolibrary.org/obo/GO_0016746) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-6792572" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "LIPT1 transfers lipoyl group from lipoyl-GCSH to DHs" +- [acyltransferase activity](http://purl.obolibrary.org/obo/GO_0016746) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "transferase activity, transferring acyl groups" -### axillary nerve `http://purl.obolibrary.org/obo/UBERON_0001493` -#### Removed -- [axillary nerve](http://purl.obolibrary.org/obo/UBERON_0001493) SubClassOf [neuron projection bundle](http://purl.obolibrary.org/obo/CARO_0001001) +- [acyltransferase activity](http://purl.obolibrary.org/obo/GO_0016746) [has_alternative_id](http://www.geneontology.org/formats/oboInOwl#hasAlternativeId) "GO:0008415" +- [acyltransferase activity](http://purl.obolibrary.org/obo/GO_0016746) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [goslim_drosophila](http://purl.obolibrary.org/obo/go#goslim_drosophila) +- Class: [acyltransferase activity](http://purl.obolibrary.org/obo/GO_0016746) -### basophil mast progenitor cell `http://purl.obolibrary.org/obo/CL_0002028` -#### Removed -- [basophil mast progenitor cell](http://purl.obolibrary.org/obo/CL_0002028) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [acyltransferase activity](http://purl.obolibrary.org/obo/GO_0016746) SubClassOf [transferase activity](http://purl.obolibrary.org/obo/GO_0016740) -### basophil progenitor cell `http://purl.obolibrary.org/obo/CL_0000613` +### alveolar capillary type 1 endothelial cell `http://purl.obolibrary.org/obo/CL_4028002` #### Removed -- [basophil progenitor cell](http://purl.obolibrary.org/obo/CL_0000613) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [alveolar capillary type 1 endothelial cell](http://purl.obolibrary.org/obo/CL_4028002) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "gCAP" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:33057196" +- [alveolar capillary type 1 endothelial cell](http://purl.obolibrary.org/obo/CL_4028002) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "CAP1" +#### Added +- [alveolar capillary type 1 endothelial cell](http://purl.obolibrary.org/obo/CL_4028002) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "CAP1" + - [comment](http://www.w3.org/2000/01/rdf-schema#comment) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation) -### basophilic erythroblast `http://purl.obolibrary.org/obo/CL_0000549` -#### Removed -- [basophilic erythroblast](http://purl.obolibrary.org/obo/CL_0000549) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [alveolar capillary type 1 endothelial cell](http://purl.obolibrary.org/obo/CL_4028002) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "gCAP" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:33057196" + - [comment](http://www.w3.org/2000/01/rdf-schema#comment) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation) -### bestrophin-4 `http://purl.obolibrary.org/obo/PR_000004724` +### alveolar capillary type 2 endothelial cell `http://purl.obolibrary.org/obo/CL_4028003` +#### Removed +- [alveolar capillary type 2 endothelial cell](http://purl.obolibrary.org/obo/CL_4028003) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "aCAP" #### Added -- [bestrophin-4](http://purl.obolibrary.org/obo/PR_000004724) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [bestrophin-4 (human)](http://purl.obolibrary.org/obo/PR_Q8NFU0) +- [alveolar capillary type 2 endothelial cell](http://purl.obolibrary.org/obo/CL_4028003) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "aCAP" + - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation) -### bilaminar disc `http://purl.obolibrary.org/obo/UBERON_0000091` +### alveolar type 1 fibroblast cell `http://purl.obolibrary.org/obo/CL_4028004` #### Removed -- [bilaminar disc](http://purl.obolibrary.org/obo/UBERON_0000091) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [alveolar type 1 fibroblast cell](http://purl.obolibrary.org/obo/CL_4028004) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "AF1" +#### Added +- [alveolar type 1 fibroblast cell](http://purl.obolibrary.org/obo/CL_4028004) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "AF1" + - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation) -### bile duct epithelium `http://purl.obolibrary.org/obo/UBERON_0004820` +### alveolar type 2 fibroblast cell `http://purl.obolibrary.org/obo/CL_4028006` #### Removed -- [bile duct epithelium](http://purl.obolibrary.org/obo/UBERON_0004820) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [alveolar type 2 fibroblast cell](http://purl.obolibrary.org/obo/CL_4028006) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "MANC" +- [alveolar type 2 fibroblast cell](http://purl.obolibrary.org/obo/CL_4028006) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "AF2" +#### Added +- [alveolar type 2 fibroblast cell](http://purl.obolibrary.org/obo/CL_4028006) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "AF2" + - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation) -### biliary system `http://purl.obolibrary.org/obo/UBERON_0002294` -#### Removed -- [biliary system](http://purl.obolibrary.org/obo/UBERON_0002294) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) - +- [alveolar type 2 fibroblast cell](http://purl.obolibrary.org/obo/CL_4028006) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "MANC" + - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation) -### biomechanically related to `http://purl.obolibrary.org/obo/RO_0002567` +### amine precursor uptake and decarboxylation cell `http://purl.obolibrary.org/obo/CL_0000568` #### Removed -- [biomechanically related to](http://purl.obolibrary.org/obo/RO_0002567) Domain [connected anatomical structure](http://purl.obolibrary.org/obo/CARO_0000003) +- [amine precursor uptake and decarboxylation cell](http://purl.obolibrary.org/obo/CL_0000568) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A cell that originates in the neural crest, that has certain cytochemical and ultrastructural characteristics and is found scattered throughout the body; types include melanocytes, the cells of the chromaffin system, and cells in the hypothalamus, hypophysis, thyroid, parathyroids, lungs, gastrointestinal tract, and pancreas. This cell type concentrates the amino acid precursors of certain amines and decarboxylate them, forming amines that function as regulators and neurotransmitters. This cell type produces substances such as epinephrine, norepinephrine, dopamine, serotonin, enkephalin, somatostatin, neurotensin, and substance P, the actions of which may affect contiguous cells, nearby groups of cells, or distant cells, thus functioning as local or systemic hormones. The name is an acronym for amine precursor uptake and decarboxylation cell." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:tfm" -- [biomechanically related to](http://purl.obolibrary.org/obo/RO_0002567) Range [connected anatomical structure](http://purl.obolibrary.org/obo/CARO_0000003) + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "MESH:A11.070" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ISBN:0721662544" #### Added -- [biomechanically related to](http://purl.obolibrary.org/obo/RO_0002567) Domain [anatomical structure](http://purl.obolibrary.org/obo/UBERON_0000061) +- [amine precursor uptake and decarboxylation cell](http://purl.obolibrary.org/obo/CL_0000568) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A cell that originates in the neural crest, that has certain cytochemical and ultrastructural characteristics and is found scattered throughout the body; types include melanocytes, the cells of the chromaffin system, and cells in the hypothalamus, hypophysis, thyroid, parathyroids, lungs, gastrointestinal tract, and pancreas. This cell type concentrates the amino acid precursors of certain amines and decarboxylate them, forming amines that function as regulators and neurotransmitters. This cell type produces substances such as epinephrine, norepinephrine, dopamine, serotonin, enkephalin, somatostatin, neurotensin, and substance P, the actions of which may affect contiguous cells, nearby groups of cells, or distant cells, thus functioning as local or systemic hormones. The name is an acronym for amine precursor uptake and decarboxylation cell." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:tfm" -- [biomechanically related to](http://purl.obolibrary.org/obo/RO_0002567) Range [anatomical structure](http://purl.obolibrary.org/obo/UBERON_0000061) + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ISBN:0721662544" +- [amine precursor uptake and decarboxylation cell](http://purl.obolibrary.org/obo/CL_0000568) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "MESH:D001078" -### bladder lumen `http://purl.obolibrary.org/obo/UBERON_0009958` -#### Removed -- [bladder lumen](http://purl.obolibrary.org/obo/UBERON_0009958) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +### amino acid export across plasma membrane `http://purl.obolibrary.org/obo/GO_0032973` +#### Added +- [amino acid export across plasma membrane](http://purl.obolibrary.org/obo/GO_0032973) [has_alternative_id](http://www.geneontology.org/formats/oboInOwl#hasAlternativeId) "GO:0044746" -### blastocyst `http://purl.obolibrary.org/obo/UBERON_0000358` -#### Removed -- [blastocyst](http://purl.obolibrary.org/obo/UBERON_0000358) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [amino acid export across plasma membrane](http://purl.obolibrary.org/obo/GO_0032973) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "amino acid export" +- [amino acid export across plasma membrane](http://purl.obolibrary.org/obo/GO_0032973) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "amino acid transmembrane export" +- [amino acid export across plasma membrane](http://purl.obolibrary.org/obo/GO_0032973) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "jl" -### blastula `http://purl.obolibrary.org/obo/UBERON_0000307` -#### Removed -- [blastula](http://purl.obolibrary.org/obo/UBERON_0000307) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [amino acid export across plasma membrane](http://purl.obolibrary.org/obo/GO_0032973) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0032973" +- [amino acid export across plasma membrane](http://purl.obolibrary.org/obo/GO_0032973) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "amino acid efflux" +- [amino acid export across plasma membrane](http://purl.obolibrary.org/obo/GO_0032973) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" -### blood `http://purl.obolibrary.org/obo/UBERON_0000178` -#### Removed -- [blood](http://purl.obolibrary.org/obo/UBERON_0000178) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [amino acid export across plasma membrane](http://purl.obolibrary.org/obo/GO_0032973) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The directed movement of amino acids from inside of a cell, across the plasma membrane and into the extracellular region." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:jl" +- [amino acid export across plasma membrane](http://purl.obolibrary.org/obo/GO_0032973) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2012-11-14T14:27:40Z" +- [amino acid export across plasma membrane](http://purl.obolibrary.org/obo/GO_0032973) [label](http://www.w3.org/2000/01/rdf-schema#label) "amino acid export across plasma membrane" -### blood clot `http://purl.obolibrary.org/obo/UBERON_0010210` -#### Removed -- [blood clot](http://purl.obolibrary.org/obo/UBERON_0010210) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- Class: [amino acid export across plasma membrane](http://purl.obolibrary.org/obo/GO_0032973) +- [amino acid export across plasma membrane](http://purl.obolibrary.org/obo/GO_0032973) EquivalentTo [transport](http://purl.obolibrary.org/obo/GO_0006810) and ([has target start location](http://purl.obolibrary.org/obo/RO_0002338) some [cytosol](http://purl.obolibrary.org/obo/GO_0005829)) and ([has target end location](http://purl.obolibrary.org/obo/RO_0002339) some [extracellular region](http://purl.obolibrary.org/obo/GO_0005576)) and ([results in transport across](http://purl.obolibrary.org/obo/RO_0002342) some [plasma membrane](http://purl.obolibrary.org/obo/GO_0005886)) and ([has primary input](http://purl.obolibrary.org/obo/RO_0004009) some [CHEBI_33709](http://purl.obolibrary.org/obo/CHEBI_33709)) +- [amino acid export across plasma membrane](http://purl.obolibrary.org/obo/GO_0032973) SubClassOf [export across plasma membrane](http://purl.obolibrary.org/obo/GO_0140115) -### blood vasculature `http://purl.obolibrary.org/obo/UBERON_0004537` -#### Removed -- [blood vasculature](http://purl.obolibrary.org/obo/UBERON_0004537) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [amino acid export across plasma membrane](http://purl.obolibrary.org/obo/GO_0032973) SubClassOf [amino acid transmembrane transport](http://purl.obolibrary.org/obo/GO_0003333) +### amino acid import across plasma membrane `http://purl.obolibrary.org/obo/GO_0089718` -### blood vessel `http://purl.obolibrary.org/obo/UBERON_0001981` -#### Removed -- [blood vessel](http://purl.obolibrary.org/obo/UBERON_0001981) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +#### Added +- [amino acid import across plasma membrane](http://purl.obolibrary.org/obo/GO_0089718) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "amino acid import into cell" +- [amino acid import across plasma membrane](http://purl.obolibrary.org/obo/GO_0089718) [label](http://www.w3.org/2000/01/rdf-schema#label) "amino acid import across plasma membrane" +- [amino acid import across plasma membrane](http://purl.obolibrary.org/obo/GO_0089718) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0089718" -### bone marrow macrophage `http://purl.obolibrary.org/obo/CL_0002476` -#### Removed -- [bone marrow macrophage](http://purl.obolibrary.org/obo/CL_0002476) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [amino acid import across plasma membrane](http://purl.obolibrary.org/obo/GO_0089718) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" +- [amino acid import across plasma membrane](http://purl.obolibrary.org/obo/GO_0089718) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "L-amino acid import" +- [amino acid import across plasma membrane](http://purl.obolibrary.org/obo/GO_0089718) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "amino acid transmembrane import" -### bone marrow proteoglycan `http://purl.obolibrary.org/obo/PR_000013206` +- [amino acid import across plasma membrane](http://purl.obolibrary.org/obo/GO_0089718) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2012-11-14T14:21:41Z" -#### Added -- [bone marrow proteoglycan](http://purl.obolibrary.org/obo/PR_000013206) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [bone marrow proteoglycan (human)](http://purl.obolibrary.org/obo/PR_P13727) +- [amino acid import across plasma membrane](http://purl.obolibrary.org/obo/GO_0089718) [has_alternative_id](http://www.geneontology.org/formats/oboInOwl#hasAlternativeId) "GO:0044745" +- [amino acid import across plasma membrane](http://purl.obolibrary.org/obo/GO_0089718) [has_alternative_id](http://www.geneontology.org/formats/oboInOwl#hasAlternativeId) "GO:0043092" -### bone marrow stromal antigen 2 `http://purl.obolibrary.org/obo/PR_000001326` +- [amino acid import across plasma membrane](http://purl.obolibrary.org/obo/GO_0089718) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The directed movement of an amino acid from outside of a cell, across the plasma membrane and into the cytosol." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:krc" -#### Added -- [bone marrow stromal antigen 2](http://purl.obolibrary.org/obo/PR_000001326) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [bone marrow stromal antigen 2 (human)](http://purl.obolibrary.org/obo/PR_Q10589) + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:8195186" +- [amino acid import across plasma membrane](http://purl.obolibrary.org/obo/GO_0089718) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "L-amino acid uptake" -### bony projection `http://purl.obolibrary.org/obo/UBERON_0004530` -#### Removed -- [bony projection](http://purl.obolibrary.org/obo/UBERON_0004530) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [amino acid import across plasma membrane](http://purl.obolibrary.org/obo/GO_0089718) [has_alternative_id](http://www.geneontology.org/formats/oboInOwl#hasAlternativeId) "GO:1902837" +- [amino acid import across plasma membrane](http://purl.obolibrary.org/obo/GO_0089718) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "jl" +- Class: [amino acid import across plasma membrane](http://purl.obolibrary.org/obo/GO_0089718) -### brachial nerve plexus `http://purl.obolibrary.org/obo/UBERON_0001814` -#### Removed -- [brachial nerve plexus](http://purl.obolibrary.org/obo/UBERON_0001814) SubClassOf [neuron projection bundle](http://purl.obolibrary.org/obo/CARO_0001001) +- [amino acid import across plasma membrane](http://purl.obolibrary.org/obo/GO_0089718) EquivalentTo [transport](http://purl.obolibrary.org/obo/GO_0006810) and ([has target start location](http://purl.obolibrary.org/obo/RO_0002338) some [extracellular region](http://purl.obolibrary.org/obo/GO_0005576)) and ([has target end location](http://purl.obolibrary.org/obo/RO_0002339) some [cytosol](http://purl.obolibrary.org/obo/GO_0005829)) and ([results in transport across](http://purl.obolibrary.org/obo/RO_0002342) some [plasma membrane](http://purl.obolibrary.org/obo/GO_0005886)) and ([has primary input](http://purl.obolibrary.org/obo/RO_0004009) some [CHEBI_33709](http://purl.obolibrary.org/obo/CHEBI_33709)) -#### Added -- [brachial nerve plexus](http://purl.obolibrary.org/obo/UBERON_0001814) SubClassOf [neuron projection bundle](http://purl.obolibrary.org/obo/UBERON_0000122) +- [amino acid import across plasma membrane](http://purl.obolibrary.org/obo/GO_0089718) SubClassOf [import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098739) +- [amino acid import across plasma membrane](http://purl.obolibrary.org/obo/GO_0089718) SubClassOf [amino acid transmembrane transport](http://purl.obolibrary.org/obo/GO_0003333) -### brain marginal zone `http://purl.obolibrary.org/obo/UBERON_0010403` -#### Removed -- [brain marginal zone](http://purl.obolibrary.org/obo/UBERON_0010403) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +### amino acid transmembrane export from vacuole `http://purl.obolibrary.org/obo/GO_0032974` +#### Added +- [amino acid transmembrane export from vacuole](http://purl.obolibrary.org/obo/GO_0032974) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "amino acid efflux from vacuole" -### brainstem motor neuron `http://purl.obolibrary.org/obo/CL_2000047` -#### Removed -- [brainstem motor neuron](http://purl.obolibrary.org/obo/CL_2000047) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [amino acid transmembrane export from vacuole](http://purl.obolibrary.org/obo/GO_0032974) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" +- [amino acid transmembrane export from vacuole](http://purl.obolibrary.org/obo/GO_0032974) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The directed movement of amino acids out of the vacuole, across the vacuolar membrane." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:mah" +- [amino acid transmembrane export from vacuole](http://purl.obolibrary.org/obo/GO_0032974) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "vacuolar amino acid export" -### branchiomotor neuron `http://purl.obolibrary.org/obo/CL_0005023` -#### Removed -- [branchiomotor neuron](http://purl.obolibrary.org/obo/CL_0005023) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [amino acid transmembrane export from vacuole](http://purl.obolibrary.org/obo/GO_0032974) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0032974" +- [amino acid transmembrane export from vacuole](http://purl.obolibrary.org/obo/GO_0032974) [label](http://www.w3.org/2000/01/rdf-schema#label) "amino acid transmembrane export from vacuole" +- Class: [amino acid transmembrane export from vacuole](http://purl.obolibrary.org/obo/GO_0032974) -### bronchial artery `http://purl.obolibrary.org/obo/UBERON_0002040` +- [amino acid transmembrane export from vacuole](http://purl.obolibrary.org/obo/GO_0032974) EquivalentTo [transport](http://purl.obolibrary.org/obo/GO_0006810) and ([has target start location](http://purl.obolibrary.org/obo/RO_0002338) some [vacuolar lumen](http://purl.obolibrary.org/obo/GO_0005775)) and ([has target end location](http://purl.obolibrary.org/obo/RO_0002339) some [cytosol](http://purl.obolibrary.org/obo/GO_0005829)) and ([results in transport across](http://purl.obolibrary.org/obo/RO_0002342) some [membrane](http://purl.obolibrary.org/obo/GO_0016020)) and ([has primary input](http://purl.obolibrary.org/obo/RO_0004009) some [CHEBI_33709](http://purl.obolibrary.org/obo/CHEBI_33709)) -#### Added -- [bronchial artery](http://purl.obolibrary.org/obo/UBERON_0002040) SubClassOf [has part](http://purl.obolibrary.org/obo/BFO_0000051) some [respiratory system arterial endothelium](http://purl.obolibrary.org/obo/UBERON_0004848) +- [amino acid transmembrane export from vacuole](http://purl.obolibrary.org/obo/GO_0032974) SubClassOf [has target start location](http://purl.obolibrary.org/obo/RO_0002338) some [vacuolar lumen](http://purl.obolibrary.org/obo/GO_0005775) -- [bronchial artery](http://purl.obolibrary.org/obo/UBERON_0002040) SubClassOf [has part](http://purl.obolibrary.org/obo/BFO_0000051) some [respiratory system arterial smooth muscle](http://purl.obolibrary.org/obo/UBERON_0012416) +- [amino acid transmembrane export from vacuole](http://purl.obolibrary.org/obo/GO_0032974) SubClassOf [amino acid transmembrane transport](http://purl.obolibrary.org/obo/GO_0003333) +- [amino acid transmembrane export from vacuole](http://purl.obolibrary.org/obo/GO_0032974) SubClassOf [vacuolar transmembrane transport](http://purl.obolibrary.org/obo/GO_0034486) -### bronchiolar smooth muscle cell `http://purl.obolibrary.org/obo/CL_4033017` -#### Removed -- [bronchiolar smooth muscle cell](http://purl.obolibrary.org/obo/CL_4033017) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [bronchiole](http://purl.obolibrary.org/obo/UBERON_0002186) +- [amino acid transmembrane export from vacuole](http://purl.obolibrary.org/obo/GO_0032974) SubClassOf [has target end location](http://purl.obolibrary.org/obo/RO_0002339) some [cytosol](http://purl.obolibrary.org/obo/GO_0005829) -#### Added -- [bronchiolar smooth muscle cell](http://purl.obolibrary.org/obo/CL_4033017) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [smooth muscle tissue of bronchiole](http://purl.obolibrary.org/obo/UBERON_0004515) +### amino acid transmembrane import into vacuole `http://purl.obolibrary.org/obo/GO_0032975` -### buccopharyngeal membrane `http://purl.obolibrary.org/obo/UBERON_0006211` -#### Removed -- [buccopharyngeal membrane](http://purl.obolibrary.org/obo/UBERON_0006211) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +#### Added +- [amino acid transmembrane import into vacuole](http://purl.obolibrary.org/obo/GO_0032975) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" +- [amino acid transmembrane import into vacuole](http://purl.obolibrary.org/obo/GO_0032975) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0032975" +- [amino acid transmembrane import into vacuole](http://purl.obolibrary.org/obo/GO_0032975) [label](http://www.w3.org/2000/01/rdf-schema#label) "amino acid transmembrane import into vacuole" -### bushy cell `http://purl.obolibrary.org/obo/CL_4023162` -#### Removed -- [bushy cell](http://purl.obolibrary.org/obo/CL_4023162) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [amino acid transmembrane import into vacuole](http://purl.obolibrary.org/obo/GO_0032975) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The directed movement of amino acids into the vacuole across the vacuolar membrane." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:mah" +- [amino acid transmembrane import into vacuole](http://purl.obolibrary.org/obo/GO_0032975) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "vacuolar amino acid import" +- Class: [amino acid transmembrane import into vacuole](http://purl.obolibrary.org/obo/GO_0032975) -### cadherin-1 `http://purl.obolibrary.org/obo/PR_000001447` +- [amino acid transmembrane import into vacuole](http://purl.obolibrary.org/obo/GO_0032975) EquivalentTo [transport](http://purl.obolibrary.org/obo/GO_0006810) and ([has target start location](http://purl.obolibrary.org/obo/RO_0002338) some [cytosol](http://purl.obolibrary.org/obo/GO_0005829)) and ([has target end location](http://purl.obolibrary.org/obo/RO_0002339) some [vacuolar lumen](http://purl.obolibrary.org/obo/GO_0005775)) and ([results in transport across](http://purl.obolibrary.org/obo/RO_0002342) some [membrane](http://purl.obolibrary.org/obo/GO_0016020)) and ([has primary input](http://purl.obolibrary.org/obo/RO_0004009) some [CHEBI_33709](http://purl.obolibrary.org/obo/CHEBI_33709)) -#### Added -- [cadherin-1](http://purl.obolibrary.org/obo/PR_000001447) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [cadherin-1 (human)](http://purl.obolibrary.org/obo/PR_P12830) +- [amino acid transmembrane import into vacuole](http://purl.obolibrary.org/obo/GO_0032975) SubClassOf [has target start location](http://purl.obolibrary.org/obo/RO_0002338) some [cytosol](http://purl.obolibrary.org/obo/GO_0005829) +- [amino acid transmembrane import into vacuole](http://purl.obolibrary.org/obo/GO_0032975) SubClassOf [has target end location](http://purl.obolibrary.org/obo/RO_0002339) some [vacuolar lumen](http://purl.obolibrary.org/obo/GO_0005775) -### cadherin-5 `http://purl.obolibrary.org/obo/PR_000001444` +- [amino acid transmembrane import into vacuole](http://purl.obolibrary.org/obo/GO_0032975) SubClassOf [vacuolar transmembrane transport](http://purl.obolibrary.org/obo/GO_0034486) -#### Added -- [cadherin-5](http://purl.obolibrary.org/obo/PR_000001444) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [cadherin-5 (human)](http://purl.obolibrary.org/obo/PR_P33151) +- [amino acid transmembrane import into vacuole](http://purl.obolibrary.org/obo/GO_0032975) SubClassOf [amino acid transmembrane transport](http://purl.obolibrary.org/obo/GO_0003333) -### caecum `http://purl.obolibrary.org/obo/UBERON_0001153` +### aminoacyltransferase activity `http://purl.obolibrary.org/obo/GO_0016755` #### Removed -- [caecum](http://purl.obolibrary.org/obo/UBERON_0001153) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [aminoacyltransferase activity](http://purl.obolibrary.org/obo/GO_0016755) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "transferase activity, transferring amino-acyl groups" +- [aminoacyltransferase activity](http://purl.obolibrary.org/obo/GO_0016755) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Catalysis of the transfer of an amino-acyl group from one compound (donor) to another (acceptor)." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:jl" +- [aminoacyltransferase activity](http://purl.obolibrary.org/obo/GO_0016755) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "molecular_function" -### camera-type eye photoreceptor cell `http://purl.obolibrary.org/obo/CL_0010009` -#### Removed -- [camera-type eye photoreceptor cell](http://purl.obolibrary.org/obo/CL_0010009) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) - +- [aminoacyltransferase activity](http://purl.obolibrary.org/obo/GO_0016755) [label](http://www.w3.org/2000/01/rdf-schema#label) "aminoacyltransferase activity" +- [aminoacyltransferase activity](http://purl.obolibrary.org/obo/GO_0016755) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0016755" -### canopy lamp5 GABAergic cortical interneuron (Mmus) `http://purl.obolibrary.org/obo/CL_4023022` - -#### Added -- [canopy lamp5 GABAergic cortical interneuron (Mmus)](http://purl.obolibrary.org/obo/CL_4023022) [symbol](http://purl.obolibrary.org/obo/IAO_0000028) "canopy lamp5 interneuron" +- [aminoacyltransferase activity](http://purl.obolibrary.org/obo/GO_0016755) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "EC:2.3.2.-" +- Class: [aminoacyltransferase activity](http://purl.obolibrary.org/obo/GO_0016755) -### carcinoembryonic antigen-related cell adhesion molecule 8 `http://purl.obolibrary.org/obo/PR_000001332` +- [aminoacyltransferase activity](http://purl.obolibrary.org/obo/GO_0016755) SubClassOf [acyltransferase activity](http://purl.obolibrary.org/obo/GO_0016746) -#### Added -- [carcinoembryonic antigen-related cell adhesion molecule 8](http://purl.obolibrary.org/obo/PR_000001332) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [carcinoembryonic antigen-related cell adhesion molecule 8 (human)](http://purl.obolibrary.org/obo/PR_P31997) -### cardiac nerve plexus `http://purl.obolibrary.org/obo/UBERON_0002008` -#### Removed -- [cardiac nerve plexus](http://purl.obolibrary.org/obo/UBERON_0002008) SubClassOf [neuron projection bundle](http://purl.obolibrary.org/obo/CARO_0001001) +### ammonium import across plasma membrane `http://purl.obolibrary.org/obo/GO_0140157` #### Added -- [cardiac nerve plexus](http://purl.obolibrary.org/obo/UBERON_0002008) SubClassOf [neuron projection bundle](http://purl.obolibrary.org/obo/UBERON_0000122) +- [ammonium import across plasma membrane](http://purl.obolibrary.org/obo/GO_0140157) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" +- [ammonium import across plasma membrane](http://purl.obolibrary.org/obo/GO_0140157) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2018-01-26T12:39:56Z" -### cardiac neuron `http://purl.obolibrary.org/obo/CL_0010022` -#### Removed -- [cardiac neuron](http://purl.obolibrary.org/obo/CL_0010022) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [ammonium import across plasma membrane](http://purl.obolibrary.org/obo/GO_0140157) [label](http://www.w3.org/2000/01/rdf-schema#label) "ammonium import across plasma membrane" +- [ammonium import across plasma membrane](http://purl.obolibrary.org/obo/GO_0140157) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The directed movement of an ammonium ion from outside of a cell, across the plasma membrane and into the cytosol." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:16999738" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:vw" -### cardiogenic plate `http://purl.obolibrary.org/obo/UBERON_0004139` -#### Removed -- [cardiogenic plate](http://purl.obolibrary.org/obo/UBERON_0004139) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [ammonium import across plasma membrane](http://purl.obolibrary.org/obo/GO_0140157) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0140157" +- [ammonium import across plasma membrane](http://purl.obolibrary.org/obo/GO_0140157) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "pg" +- Class: [ammonium import across plasma membrane](http://purl.obolibrary.org/obo/GO_0140157) -### cardiogenic splanchnic mesoderm `http://purl.obolibrary.org/obo/UBERON_0007005` -#### Removed -- [cardiogenic splanchnic mesoderm](http://purl.obolibrary.org/obo/UBERON_0007005) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [ammonium import across plasma membrane](http://purl.obolibrary.org/obo/GO_0140157) EquivalentTo [transport](http://purl.obolibrary.org/obo/GO_0006810) and ([has target start location](http://purl.obolibrary.org/obo/RO_0002338) some [extracellular region](http://purl.obolibrary.org/obo/GO_0005576)) and ([has target end location](http://purl.obolibrary.org/obo/RO_0002339) some [cytosol](http://purl.obolibrary.org/obo/GO_0005829)) and ([results in transport across](http://purl.obolibrary.org/obo/RO_0002342) some [plasma membrane](http://purl.obolibrary.org/obo/GO_0005886)) and ([has primary input](http://purl.obolibrary.org/obo/RO_0004009) some [CHEBI_28938](http://purl.obolibrary.org/obo/CHEBI_28938)) +- [ammonium import across plasma membrane](http://purl.obolibrary.org/obo/GO_0140157) SubClassOf [import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098739) +- [ammonium import across plasma membrane](http://purl.obolibrary.org/obo/GO_0140157) SubClassOf [ammonium transmembrane transport](http://purl.obolibrary.org/obo/GO_0072488) -### cardiovascular system `http://purl.obolibrary.org/obo/UBERON_0004535` -#### Removed -- [cardiovascular system](http://purl.obolibrary.org/obo/UBERON_0004535) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +### anatomical structure maturation `http://purl.obolibrary.org/obo/GO_0071695` +#### Removed +- [anatomical structure maturation](http://purl.obolibrary.org/obo/GO_0071695) EquivalentTo [developmental maturation](http://purl.obolibrary.org/obo/GO_0021700) and ([results in maturation of](http://purl.obolibrary.org/obo/RO_0002299) some [connected anatomical structure](http://purl.obolibrary.org/obo/CARO_0000003)) +- [anatomical structure maturation](http://purl.obolibrary.org/obo/GO_0071695) SubClassOf [results in maturation of](http://purl.obolibrary.org/obo/RO_0002299) some [connected anatomical structure](http://purl.obolibrary.org/obo/CARO_0000003) -### cartilaginous joint `http://purl.obolibrary.org/obo/UBERON_0002213` -#### Removed -- [cartilaginous joint](http://purl.obolibrary.org/obo/UBERON_0002213) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +#### Added +- [anatomical structure maturation](http://purl.obolibrary.org/obo/GO_0071695) EquivalentTo [developmental maturation](http://purl.obolibrary.org/obo/GO_0021700) and ([results in maturation of](http://purl.obolibrary.org/obo/RO_0002299) some [anatomical structure](http://purl.obolibrary.org/obo/UBERON_0000061)) +- [anatomical structure maturation](http://purl.obolibrary.org/obo/GO_0071695) SubClassOf [results in maturation of](http://purl.obolibrary.org/obo/RO_0002299) some [anatomical structure](http://purl.obolibrary.org/obo/UBERON_0000061) -### cartilaginous neurocranium `http://purl.obolibrary.org/obo/UBERON_0004761` +### anatomical structure regression `http://purl.obolibrary.org/obo/GO_0060033` #### Removed -- [cartilaginous neurocranium](http://purl.obolibrary.org/obo/UBERON_0004761) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [anatomical structure regression](http://purl.obolibrary.org/obo/GO_0060033) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "tissue death" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:mtg_apoptosis" +- [anatomical structure regression](http://purl.obolibrary.org/obo/GO_0060033) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The developmental process in which an anatomical stucture is destroyed as a part of its normal progression." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dph" +- [anatomical structure regression](http://purl.obolibrary.org/obo/GO_0060033) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" -### cartilaginous projection `http://purl.obolibrary.org/obo/UBERON_0011769` -#### Removed -- [cartilaginous projection](http://purl.obolibrary.org/obo/UBERON_0011769) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [anatomical structure regression](http://purl.obolibrary.org/obo/GO_0060033) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0060033" +- [anatomical structure regression](http://purl.obolibrary.org/obo/GO_0060033) [label](http://www.w3.org/2000/01/rdf-schema#label) "anatomical structure regression" +- [anatomical structure regression](http://purl.obolibrary.org/obo/GO_0060033) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "histolysis" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:mtg_apoptosis" -### cartwheel cell `http://purl.obolibrary.org/obo/CL_4023160` -#### Removed -- [cartwheel cell](http://purl.obolibrary.org/obo/CL_4023160) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- Class: [anatomical structure regression](http://purl.obolibrary.org/obo/GO_0060033) -- [cartwheel cell](http://purl.obolibrary.org/obo/CL_4023160) SubClassOf [synapsed_by](http://purl.obolibrary.org/obo/uberon/core#synapsed_by) some [granule cell](http://purl.obolibrary.org/obo/CL_0000120) +- [anatomical structure regression](http://purl.obolibrary.org/obo/GO_0060033) SubClassOf [only in taxon](http://purl.obolibrary.org/obo/RO_0002160) some [Eukaryota](http://purl.obolibrary.org/obo/NCBITaxon_2759) -#### Added -- [cartwheel cell](http://purl.obolibrary.org/obo/CL_4023160) SubClassOf [synapsed by](http://purl.obolibrary.org/obo/RO_0002103) some [granule cell](http://purl.obolibrary.org/obo/CL_0000120) +- [anatomical structure regression](http://purl.obolibrary.org/obo/GO_0060033) SubClassOf [in taxon](http://purl.obolibrary.org/obo/RO_0002162) only [Eukaryota](http://purl.obolibrary.org/obo/NCBITaxon_2759) +- [anatomical structure regression](http://purl.obolibrary.org/obo/GO_0060033) SubClassOf [developmental process](http://purl.obolibrary.org/obo/GO_0032502) -### cathepsin K `http://purl.obolibrary.org/obo/PR_000001850` +- [anatomical structure regression](http://purl.obolibrary.org/obo/GO_0060033) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [anatomical structure morphogenesis](http://purl.obolibrary.org/obo/GO_0009653) -#### Added -- [cathepsin K](http://purl.obolibrary.org/obo/PR_000001850) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [cathepsin K (human)](http://purl.obolibrary.org/obo/PR_P43235) -### caudal ganglionic eminence derived GABAergic cortical interneuron `http://purl.obolibrary.org/obo/CL_4023070` +### animal cell `http://purl.obolibrary.org/obo/CL_0000548` #### Added -- [caudal ganglionic eminence derived GABAergic cortical interneuron](http://purl.obolibrary.org/obo/CL_4023070) [symbol](http://purl.obolibrary.org/obo/IAO_0000028) "CGE gaba cortical interneuron" +- [animal cell](http://purl.obolibrary.org/obo/CL_0000548) [depicted by](http://xmlns.com/foaf/0.1/depicted_by) "https://www.swissbiopics.org/api/image/Animal_cells.svg"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI) -### caudal ganglionic eminence derived interneuron `http://purl.obolibrary.org/obo/CL_4023064` +### anterior lateral line nerve glial cell morphogenesis involved in differentiation `http://purl.obolibrary.org/obo/GO_0048940` #### Removed -- [caudal ganglionic eminence derived interneuron](http://purl.obolibrary.org/obo/CL_4023064) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [anterior lateral line nerve glial cell morphogenesis involved in differentiation](http://purl.obolibrary.org/obo/GO_0048940) EquivalentTo [cell morphogenesis involved in differentiation](http://purl.obolibrary.org/obo/GO_0000904) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [anterior lateral line nerve glial cell development](http://purl.obolibrary.org/obo/GO_0048939)) #### Added -- [caudal ganglionic eminence derived interneuron](http://purl.obolibrary.org/obo/CL_4023064) [symbol](http://purl.obolibrary.org/obo/IAO_0000028) "CGE interneuron" +- [anterior lateral line nerve glial cell morphogenesis involved in differentiation](http://purl.obolibrary.org/obo/GO_0048940) EquivalentTo [cell morphogenesis](http://purl.obolibrary.org/obo/GO_0000902) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [anterior lateral line nerve glial cell development](http://purl.obolibrary.org/obo/GO_0048939)) -### caudal region `http://purl.obolibrary.org/obo/UBERON_0006071` -#### Removed -- [caudal region](http://purl.obolibrary.org/obo/UBERON_0006071) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000) +### anterograde neuronal dense core vesicle transport `http://purl.obolibrary.org/obo/GO_1990048` +#### Added +- [anterograde neuronal dense core vesicle transport](http://purl.obolibrary.org/obo/GO_1990048) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:1990048" +- [anterograde neuronal dense core vesicle transport](http://purl.obolibrary.org/obo/GO_1990048) [label](http://www.w3.org/2000/01/rdf-schema#label) "anterograde neuronal dense core vesicle transport" -### causally upstream of or within, negative effect `http://purl.obolibrary.org/obo/RO_0004046` +- [anterograde neuronal dense core vesicle transport](http://purl.obolibrary.org/obo/GO_1990048) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" -#### Added -- [causally upstream of or within, negative effect](http://purl.obolibrary.org/obo/RO_0004046) [see also](http://www.w3.org/2000/01/rdf-schema#seeAlso) "https://wiki.geneontology.org/Causally_upstream_of_or_within,_negative_effect"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI) +- [anterograde neuronal dense core vesicle transport](http://purl.obolibrary.org/obo/GO_1990048) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "anterograde dense core granule trafficking" +- [anterograde neuronal dense core vesicle transport](http://purl.obolibrary.org/obo/GO_1990048) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The directed movement of substances in neuronal dense core vesicles along axonal microtubules towards the presynapse." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:23358451" -### causally upstream of or within, positive effect `http://purl.obolibrary.org/obo/RO_0004047` + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:kmv" -#### Added -- [causally upstream of or within, positive effect](http://purl.obolibrary.org/obo/RO_0004047) [see also](http://www.w3.org/2000/01/rdf-schema#seeAlso) [_positive_effect](https://wiki.geneontology.org/Causally_upstream_of_or_within,_positive_effect) +- [anterograde neuronal dense core vesicle transport](http://purl.obolibrary.org/obo/GO_1990048) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [goslim_synapse](http://purl.obolibrary.org/obo/go#goslim_synapse) +- [anterograde neuronal dense core vesicle transport](http://purl.obolibrary.org/obo/GO_1990048) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "anterograde dense core granule transport" -### causally upstream of, negative effect `http://purl.obolibrary.org/obo/RO_0002305` +- Class: [anterograde neuronal dense core vesicle transport](http://purl.obolibrary.org/obo/GO_1990048) -#### Added -- [causally upstream of, negative effect](http://purl.obolibrary.org/obo/RO_0002305) [see also](http://www.w3.org/2000/01/rdf-schema#seeAlso) [_negative_effect](https://wiki.geneontology.org/Causally_upstream_of,_negative_effect) +- [anterograde neuronal dense core vesicle transport](http://purl.obolibrary.org/obo/GO_1990048) EquivalentTo [transport](http://purl.obolibrary.org/obo/GO_0006810) and ([occurs in](http://purl.obolibrary.org/obo/BFO_0000066) some [axon cytoplasm](http://purl.obolibrary.org/obo/GO_1904115)) and ([has target end location](http://purl.obolibrary.org/obo/RO_0002339) some [presynapse](http://purl.obolibrary.org/obo/GO_0098793)) and ([results in transport along](http://purl.obolibrary.org/obo/RO_0002341) some [microtubule](http://purl.obolibrary.org/obo/GO_0005874)) and ([has primary input](http://purl.obolibrary.org/obo/RO_0004009) some [neuronal dense core vesicle](http://purl.obolibrary.org/obo/GO_0098992)) +- [anterograde neuronal dense core vesicle transport](http://purl.obolibrary.org/obo/GO_1990048) SubClassOf [anterograde axonal transport](http://purl.obolibrary.org/obo/GO_0008089) -### causally upstream of, positive effect `http://purl.obolibrary.org/obo/RO_0002304` +- [anterograde neuronal dense core vesicle transport](http://purl.obolibrary.org/obo/GO_1990048) SubClassOf [vesicle transport along microtubule](http://purl.obolibrary.org/obo/GO_0047496) -#### Added -- [causally upstream of, positive effect](http://purl.obolibrary.org/obo/RO_0002304) [see also](http://www.w3.org/2000/01/rdf-schema#seeAlso) [_positive_effect](https://wiki.geneontology.org/Causally_upstream_of,_positive_effect) +- [anterograde neuronal dense core vesicle transport](http://purl.obolibrary.org/obo/GO_1990048) SubClassOf [dense core granule cytoskeletal transport](http://purl.obolibrary.org/obo/GO_0099519) +- [anterograde neuronal dense core vesicle transport](http://purl.obolibrary.org/obo/GO_1990048) SubClassOf [has primary input](http://purl.obolibrary.org/obo/RO_0004009) some [neuronal dense core vesicle](http://purl.obolibrary.org/obo/GO_0098992) -### cavity of pharynx `http://purl.obolibrary.org/obo/UBERON_0001731` + +### arachnoid barrier cell `http://purl.obolibrary.org/obo/CL_4023097` #### Removed -- [cavity of pharynx](http://purl.obolibrary.org/obo/UBERON_0001731) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [arachnoid barrier cell](http://purl.obolibrary.org/obo/CL_4023097) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "ABC" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:30096314" +- [arachnoid barrier cell](http://purl.obolibrary.org/obo/CL_4023097) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "AB cell" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:23298861" +#### Added +- [arachnoid barrier cell](http://purl.obolibrary.org/obo/CL_4023097) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "AB cell" + - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation) -### central tendon of diaphragm `http://purl.obolibrary.org/obo/UBERON_0006670` -#### Removed -- [central tendon of diaphragm](http://purl.obolibrary.org/obo/UBERON_0006670) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000) + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:23298861" +- [arachnoid barrier cell](http://purl.obolibrary.org/obo/CL_4023097) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "ABC" + - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation) + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:30096314" -### cerebellar granule cell `http://purl.obolibrary.org/obo/CL_0001031` +### autophagic cell death `http://purl.obolibrary.org/obo/GO_0048102` #### Removed -- [cerebellar granule cell](http://purl.obolibrary.org/obo/CL_0001031) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Granule cell that is part of the cerebellum." +- [autophagic cell death](http://purl.obolibrary.org/obo/GO_0048102) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A form of programmed cell death that is accompanied by the formation of autophagosomes. Autophagic cell death is characterized by lack of chromatin condensation and massive vacuolization of the cytoplasm, with little or no uptake by phagocytic cells." - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:mah" -- [cerebellar granule cell](http://purl.obolibrary.org/obo/CL_0001031) SubClassOf [granule cell](http://purl.obolibrary.org/obo/CL_0000120) - - [is_inferred](http://www.geneontology.org/formats/oboInOwl#is_inferred) "true" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:18846107" -- [cerebellar granule cell](http://purl.obolibrary.org/obo/CL_0001031) SubClassOf [cerebellar neuron](http://purl.obolibrary.org/obo/CL_1001611) + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:23347517" -#### Added -- [cerebellar granule cell](http://purl.obolibrary.org/obo/CL_0001031) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "An excitatory granule cell with a soma located in the granular layer of cerebellar cortex. A mature cerebellar granule cell has short dendrites with a characteristic claw-like appearance and a long axon that ascends to the molecular layer where it bifurcates (except in non-teleost fish, where it does not bifurcate) and extends mediolaterally to form parallel fibers." - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:mah" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:autophagy" - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.3389/fncir.2020.611841" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:mtg_apoptosis" - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.12688/f1000research.15021.1" +- [autophagic cell death](http://purl.obolibrary.org/obo/GO_0048102) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "autosis" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:25236395" -- [cerebellar granule cell](http://purl.obolibrary.org/obo/CL_0001031) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "granule cell of the cerebellum" - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.3389/fncir.2020.611841" +- [autophagic cell death](http://purl.obolibrary.org/obo/GO_0048102) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "programmed cell death by autophagy" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:pr" -- [cerebellar granule cell](http://purl.obolibrary.org/obo/CL_0001031) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "It has been noted in at least some mammalian species that granule cells are the most numerous cell type in the cerebellum and in the brain, with at least 99% of all cerebellar neurons being granule cells." - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.3389/fncir.2020.611841" +- [autophagic cell death](http://purl.obolibrary.org/obo/GO_0048102) [label](http://www.w3.org/2000/01/rdf-schema#label) "autophagic cell death" -- [cerebellar granule cell](http://purl.obolibrary.org/obo/CL_0001031) SubClassOf [cerebellum glutamatergic neuron](http://purl.obolibrary.org/obo/CL_2000028) +- [autophagic cell death](http://purl.obolibrary.org/obo/GO_0048102) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "programmed cell death by macroautophagy" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:cjm" -- [cerebellar granule cell](http://purl.obolibrary.org/obo/CL_0001031) SubClassOf [ectoderm-derived structure](http://purl.obolibrary.org/obo/UBERON_0004121) +- [autophagic cell death](http://purl.obolibrary.org/obo/GO_0048102) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" -- [cerebellar granule cell](http://purl.obolibrary.org/obo/CL_0001031) SubClassOf [granule cell](http://purl.obolibrary.org/obo/CL_0000120) +- [autophagic cell death](http://purl.obolibrary.org/obo/GO_0048102) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "The precise nature of autophagic cell death is still being debated, and the link between autophagy and cell death unclear. As autophagy is often induced under conditions of stress that could also lead to cell death, there has been a propagation of the idea that autophagy can act as a cell death mechanism; but others suggest that autophagy may simply be an attempt of dying cells to adapt to lethal stress rather than a mechanism to execute a cell death program. Further studies are required to resolve this controversy (see e.g. PMID:22082964, PMID:22052193, PMID:25236395). In the meantime, curators should carefully examine the experimental evidence presented in papers concerning autophagic cell death, and annotate accordingly. Recently, an instance of autophagic cell death, termed autosis, was discovered that relies on the plasma membrane Na+/K+-ATPase. Autosis was observed in vivo in the brain of rats subjected to an ischemic insult. It's still unclear if all cases of autophagic cell death require the Na+/K+-ATPase or not." -- [cerebellar granule cell](http://purl.obolibrary.org/obo/CL_0001031) SubClassOf [directly develops from](http://purl.obolibrary.org/obo/RO_0002207) some [granule cell precursor](http://purl.obolibrary.org/obo/CL_0002362) +- [autophagic cell death](http://purl.obolibrary.org/obo/GO_0048102) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "type II programmed cell death" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:sl" +- [autophagic cell death](http://purl.obolibrary.org/obo/GO_0048102) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "autophagic death" -### cerebellar granule cell differentiation `http://purl.obolibrary.org/obo/GO_0021707` +- [autophagic cell death](http://purl.obolibrary.org/obo/GO_0048102) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0048102" -#### Added -- [cerebellar granule cell differentiation](http://purl.obolibrary.org/obo/GO_0021707) SubClassOf [glutamatergic neuron differentiation](http://purl.obolibrary.org/obo/GO_1905962) +- Class: [autophagic cell death](http://purl.obolibrary.org/obo/GO_0048102) +- [autophagic cell death](http://purl.obolibrary.org/obo/GO_0048102) EquivalentTo [programmed cell death](http://purl.obolibrary.org/obo/GO_0012501) and ([has part](http://purl.obolibrary.org/obo/BFO_0000051) some [macroautophagy](http://purl.obolibrary.org/obo/GO_0016236)) -### cerebellar neuron `http://purl.obolibrary.org/obo/CL_1001611` -#### Removed -- [cerebellar neuron](http://purl.obolibrary.org/obo/CL_1001611) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [autophagic cell death](http://purl.obolibrary.org/obo/GO_0048102) SubClassOf [programmed cell death](http://purl.obolibrary.org/obo/GO_0012501) +- [autophagic cell death](http://purl.obolibrary.org/obo/GO_0048102) SubClassOf [has part](http://purl.obolibrary.org/obo/BFO_0000051) some [macroautophagy](http://purl.obolibrary.org/obo/GO_0016236) +- [autophagic cell death](http://purl.obolibrary.org/obo/GO_0048102) SubClassOf [only in taxon](http://purl.obolibrary.org/obo/RO_0002160) some [Eukaryota](http://purl.obolibrary.org/obo/NCBITaxon_2759) -### cerebral cortex `http://purl.obolibrary.org/obo/UBERON_0000956` -#### Removed -- [cerebral cortex](http://purl.obolibrary.org/obo/UBERON_0000956) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [autophagic cell death](http://purl.obolibrary.org/obo/GO_0048102) SubClassOf [in taxon](http://purl.obolibrary.org/obo/RO_0002162) only [Eukaryota](http://purl.obolibrary.org/obo/NCBITaxon_2759) -### cerebral cortex marginal layer `http://purl.obolibrary.org/obo/UBERON_0014935` +### autophagosome `http://purl.obolibrary.org/obo/GO_0005776` #### Removed -- [cerebral cortex marginal layer](http://purl.obolibrary.org/obo/UBERON_0014935) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) - +- [autophagosome](http://purl.obolibrary.org/obo/GO_0005776) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "NIF_Subcellular:sao8663416959" +- [autophagosome](http://purl.obolibrary.org/obo/GO_0005776) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0005776" -### cerebral cortex neuron `http://purl.obolibrary.org/obo/CL_0010012` -#### Removed -- [cerebral cortex neuron](http://purl.obolibrary.org/obo/CL_0010012) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [autophagosome](http://purl.obolibrary.org/obo/GO_0005776) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A double-membrane-bounded compartment that engulfs endogenous cellular material as well as invading microorganisms to target them to the lytic vacuole/lysosome for degradation as part of macroautophagy." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:11099404" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:autophagy" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ISBN:0198547684" -### chandelier pvalb GABAergic cortical interneuron `http://purl.obolibrary.org/obo/CL_4023036` +- [autophagosome](http://purl.obolibrary.org/obo/GO_0005776) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "autophagic vacuole" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "NIF_Subcellular:sao8663416959" -#### Added -- [chandelier pvalb GABAergic cortical interneuron](http://purl.obolibrary.org/obo/CL_4023036) [symbol](http://purl.obolibrary.org/obo/IAO_0000028) "chandelier PV interneuron" +- [autophagosome](http://purl.obolibrary.org/obo/GO_0005776) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "initial autophagic vacuole" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "NIF_Subcellular:sao8663416959" +- [autophagosome](http://purl.obolibrary.org/obo/GO_0005776) [label](http://www.w3.org/2000/01/rdf-schema#label) "autophagosome" -### cholangiocyte `http://purl.obolibrary.org/obo/CL_1000488` -#### Removed -- [cholangiocyte](http://purl.obolibrary.org/obo/CL_1000488) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [autophagosome](http://purl.obolibrary.org/obo/GO_0005776) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "cellular_component" +- Class: [autophagosome](http://purl.obolibrary.org/obo/GO_0005776) +- [autophagosome](http://purl.obolibrary.org/obo/GO_0005776) SubClassOf [vacuole](http://purl.obolibrary.org/obo/GO_0005773) -### cholecystokinin `http://purl.obolibrary.org/obo/PR_000005110` +- [autophagosome](http://purl.obolibrary.org/obo/GO_0005776) SubClassOf [capable of part of](http://purl.obolibrary.org/obo/RO_0002216) some [macroautophagy](http://purl.obolibrary.org/obo/GO_0016236) -#### Added -- [cholecystokinin](http://purl.obolibrary.org/obo/PR_000005110) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [cholecystokinin (human)](http://purl.obolibrary.org/obo/PR_P06307) -### chondroblast `http://purl.obolibrary.org/obo/CL_0000058` +### autophagosome assembly `http://purl.obolibrary.org/obo/GO_0000045` #### Removed -- [chondroblast](http://purl.obolibrary.org/obo/CL_0000058) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) - - +- [autophagosome assembly](http://purl.obolibrary.org/obo/GO_0000045) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "autophagosome biosynthesis" -### chondrolectin `http://purl.obolibrary.org/obo/PR_000005444` +- [autophagosome assembly](http://purl.obolibrary.org/obo/GO_0000045) [label](http://www.w3.org/2000/01/rdf-schema#label) "autophagosome assembly" -#### Added -- [chondrolectin](http://purl.obolibrary.org/obo/PR_000005444) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [chondrolectin (human)](http://purl.obolibrary.org/obo/PR_Q9H9P2) +- [autophagosome assembly](http://purl.obolibrary.org/obo/GO_0000045) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" +- [autophagosome assembly](http://purl.obolibrary.org/obo/GO_0000045) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0000045" -### chordate pharynx `http://purl.obolibrary.org/obo/UBERON_0001042` -#### Removed -- [chordate pharynx](http://purl.obolibrary.org/obo/UBERON_0001042) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [autophagosome assembly](http://purl.obolibrary.org/obo/GO_0000045) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "PAS formation" +- [autophagosome assembly](http://purl.obolibrary.org/obo/GO_0000045) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "autophagic vacuole assembly" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:autophagy" +- [autophagosome assembly](http://purl.obolibrary.org/obo/GO_0000045) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The formation of a double membrane-bounded structure, the autophagosome, that occurs when a specialized membrane sac, called the isolation membrane, starts to enclose a portion of the cytoplasm." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:9412464" -### chorion membrane `http://purl.obolibrary.org/obo/UBERON_0003124` -#### Removed -- [chorion membrane](http://purl.obolibrary.org/obo/UBERON_0003124) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:autophagy" +- [autophagosome assembly](http://purl.obolibrary.org/obo/GO_0000045) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "autophagosome formation" +- [autophagosome assembly](http://purl.obolibrary.org/obo/GO_0000045) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "autophagic vacuole formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:mah" -### chorionic ectoderm `http://purl.obolibrary.org/obo/UBERON_0003374` -#### Removed -- [chorionic ectoderm](http://purl.obolibrary.org/obo/UBERON_0003374) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- Class: [autophagosome assembly](http://purl.obolibrary.org/obo/GO_0000045) +- [autophagosome assembly](http://purl.obolibrary.org/obo/GO_0000045) EquivalentTo [cellular component assembly](http://purl.obolibrary.org/obo/GO_0022607) and ([results in assembly of](http://purl.obolibrary.org/obo/RO_0002588) some [autophagosome](http://purl.obolibrary.org/obo/GO_0005776)) +- [autophagosome assembly](http://purl.obolibrary.org/obo/GO_0000045) SubClassOf [has part](http://purl.obolibrary.org/obo/BFO_0000051) some [Atg12 ligase activity](http://purl.obolibrary.org/obo/GO_0061660) -### chorionic villus `http://purl.obolibrary.org/obo/UBERON_0007106` -#### Removed -- [chorionic villus](http://purl.obolibrary.org/obo/UBERON_0007106) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [autophagosome assembly](http://purl.obolibrary.org/obo/GO_0000045) SubClassOf [organelle assembly](http://purl.obolibrary.org/obo/GO_0070925) +- [autophagosome assembly](http://purl.obolibrary.org/obo/GO_0000045) SubClassOf [results in assembly of](http://purl.obolibrary.org/obo/RO_0002588) some [autophagosome](http://purl.obolibrary.org/obo/GO_0005776) +- [autophagosome assembly](http://purl.obolibrary.org/obo/GO_0000045) SubClassOf [has part](http://purl.obolibrary.org/obo/BFO_0000051) some [protein-phosphatidylethanolamide deconjugating activity](http://purl.obolibrary.org/obo/GO_0019786) -### chorioretinal region `http://purl.obolibrary.org/obo/UBERON_0019207` -#### Removed -- [chorioretinal region](http://purl.obolibrary.org/obo/UBERON_0019207) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [autophagosome assembly](http://purl.obolibrary.org/obo/GO_0000045) SubClassOf [starts with](http://purl.obolibrary.org/obo/RO_0002224) some [Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1904745) +- [autophagosome assembly](http://purl.obolibrary.org/obo/GO_0000045) SubClassOf [has part](http://purl.obolibrary.org/obo/BFO_0000051) some [Atg12 activating enzyme activity](http://purl.obolibrary.org/obo/GO_0019778) +- [autophagosome assembly](http://purl.obolibrary.org/obo/GO_0000045) SubClassOf [autophagosome organization](http://purl.obolibrary.org/obo/GO_1905037) -### choroid plexus stroma `http://purl.obolibrary.org/obo/UBERON_0005206` -#### Removed -- [choroid plexus stroma](http://purl.obolibrary.org/obo/UBERON_0005206) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [autophagosome assembly](http://purl.obolibrary.org/obo/GO_0000045) SubClassOf [has part](http://purl.obolibrary.org/obo/BFO_0000051) some [Atg12 conjugating enzyme activity](http://purl.obolibrary.org/obo/GO_0061651) -### choroidal cell of the eye `http://purl.obolibrary.org/obo/CL_0000348` +### autophagosome localization `http://purl.obolibrary.org/obo/GO_0061906` #### Removed -- [choroidal cell of the eye](http://purl.obolibrary.org/obo/CL_0000348) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [autophagosome localization](http://purl.obolibrary.org/obo/GO_0061906) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2017-06-28T17:27:57Z" +- [autophagosome localization](http://purl.obolibrary.org/obo/GO_0061906) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process in which an autophagosome is transported to, and/or maintained in, a specific location within the cell." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:26763909" +- [autophagosome localization](http://purl.obolibrary.org/obo/GO_0061906) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" -### ciliary body `http://purl.obolibrary.org/obo/UBERON_0001775` -#### Removed -- [ciliary body](http://purl.obolibrary.org/obo/UBERON_0001775) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [autophagosome localization](http://purl.obolibrary.org/obo/GO_0061906) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0061906" +- [autophagosome localization](http://purl.obolibrary.org/obo/GO_0061906) [label](http://www.w3.org/2000/01/rdf-schema#label) "autophagosome localization" +- [autophagosome localization](http://purl.obolibrary.org/obo/GO_0061906) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "dph" -### classical monocyte `http://purl.obolibrary.org/obo/CL_0000860` -#### Removed -- [classical monocyte](http://purl.obolibrary.org/obo/CL_0000860) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- Class: [autophagosome localization](http://purl.obolibrary.org/obo/GO_0061906) +- [autophagosome localization](http://purl.obolibrary.org/obo/GO_0061906) EquivalentTo [localization](http://purl.obolibrary.org/obo/GO_0051179) and ([has primary input](http://purl.obolibrary.org/obo/RO_0004009) some [autophagosome](http://purl.obolibrary.org/obo/GO_0005776)) +- [autophagosome localization](http://purl.obolibrary.org/obo/GO_0061906) SubClassOf [has primary input](http://purl.obolibrary.org/obo/RO_0004009) some [autophagosome](http://purl.obolibrary.org/obo/GO_0005776) -### clavicle bone primordium `http://purl.obolibrary.org/obo/UBERON_0010905` -#### Removed -- [clavicle bone primordium](http://purl.obolibrary.org/obo/UBERON_0010905) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [autophagosome localization](http://purl.obolibrary.org/obo/GO_0061906) SubClassOf [vacuolar localization](http://purl.obolibrary.org/obo/GO_1990849) -### cloacal membrane `http://purl.obolibrary.org/obo/UBERON_0006217` +### autophagosome membrane `http://purl.obolibrary.org/obo/GO_0000421` #### Removed -- [cloacal membrane](http://purl.obolibrary.org/obo/UBERON_0006217) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [autophagosome membrane](http://purl.obolibrary.org/obo/GO_0000421) [label](http://www.w3.org/2000/01/rdf-schema#label) "autophagosome membrane" +- [autophagosome membrane](http://purl.obolibrary.org/obo/GO_0000421) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0000421" +- [autophagosome membrane](http://purl.obolibrary.org/obo/GO_0000421) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The lipid bilayer surrounding an autophagosome, a double-membrane-bounded vesicle in which endogenous cellular material is sequestered." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:isa_complete" -### club cell `http://purl.obolibrary.org/obo/CL_0000158` -#### Removed -- [club cell](http://purl.obolibrary.org/obo/CL_0000158) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:autophagy" +- [autophagosome membrane](http://purl.obolibrary.org/obo/GO_0000421) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "cellular_component" +- [autophagosome membrane](http://purl.obolibrary.org/obo/GO_0000421) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "autophagic vacuole membrane" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:autophagy" -### cochlear nerve `http://purl.obolibrary.org/obo/UBERON_0004727` -#### Removed -- [cochlear nerve](http://purl.obolibrary.org/obo/UBERON_0004727) SubClassOf [neuron projection bundle](http://purl.obolibrary.org/obo/CARO_0001001) +- Class: [autophagosome membrane](http://purl.obolibrary.org/obo/GO_0000421) +- [autophagosome membrane](http://purl.obolibrary.org/obo/GO_0000421) EquivalentTo [membrane](http://purl.obolibrary.org/obo/GO_0016020) and ([bounding layer of](http://purl.obolibrary.org/obo/RO_0002007) some [autophagosome](http://purl.obolibrary.org/obo/GO_0005776)) +- [autophagosome membrane](http://purl.obolibrary.org/obo/GO_0000421) SubClassOf [bounding layer of](http://purl.obolibrary.org/obo/RO_0002007) some [autophagosome](http://purl.obolibrary.org/obo/GO_0005776) -### coelemic cavity lumen `http://purl.obolibrary.org/obo/UBERON_0002323` -#### Removed -- [coelemic cavity lumen](http://purl.obolibrary.org/obo/UBERON_0002323) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [autophagosome membrane](http://purl.obolibrary.org/obo/GO_0000421) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [autophagosome](http://purl.obolibrary.org/obo/GO_0005776) +- [autophagosome membrane](http://purl.obolibrary.org/obo/GO_0000421) SubClassOf [vacuolar membrane](http://purl.obolibrary.org/obo/GO_0005774) -### coelomic epithelium `http://purl.obolibrary.org/obo/UBERON_0005891` + +### autophagosome membrane disassembly `http://purl.obolibrary.org/obo/GO_0030399` #### Removed -- [coelomic epithelium](http://purl.obolibrary.org/obo/UBERON_0005891) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [autophagosome membrane disassembly](http://purl.obolibrary.org/obo/GO_0030399) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The controlled breakdown of the membranes of autophagosomes." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:mah" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:autophagy" +- [autophagosome membrane disassembly](http://purl.obolibrary.org/obo/GO_0030399) [label](http://www.w3.org/2000/01/rdf-schema#label) "autophagosome membrane disassembly" -### collagen alpha-1(I) chain `http://purl.obolibrary.org/obo/PR_000003264` +- [autophagosome membrane disassembly](http://purl.obolibrary.org/obo/GO_0030399) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "autophagic membrane degradation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:autophagy" -#### Added -- [collagen alpha-1(I) chain](http://purl.obolibrary.org/obo/PR_000003264) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [collagen alpha-1(I) chain (human)](http://purl.obolibrary.org/obo/PR_P02452) +- [autophagosome membrane disassembly](http://purl.obolibrary.org/obo/GO_0030399) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "autophagic membrane catabolism" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:autophagy" +- [autophagosome membrane disassembly](http://purl.obolibrary.org/obo/GO_0030399) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" -### collection of hairs `http://purl.obolibrary.org/obo/UBERON_0010164` -#### Removed -- [collection of hairs](http://purl.obolibrary.org/obo/UBERON_0010164) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [autophagosome membrane disassembly](http://purl.obolibrary.org/obo/GO_0030399) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "autophagic membrane breakdown" +- [autophagosome membrane disassembly](http://purl.obolibrary.org/obo/GO_0030399) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0030399" +- [autophagosome membrane disassembly](http://purl.obolibrary.org/obo/GO_0030399) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "autophagic vacuole membrane disassembly" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:autophagy" -### comma-shaped body `http://purl.obolibrary.org/obo/UBERON_0004198` -#### Removed -- [comma-shaped body](http://purl.obolibrary.org/obo/UBERON_0004198) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- Class: [autophagosome membrane disassembly](http://purl.obolibrary.org/obo/GO_0030399) +- [autophagosome membrane disassembly](http://purl.obolibrary.org/obo/GO_0030399) EquivalentTo [cellular component disassembly](http://purl.obolibrary.org/obo/GO_0022411) and ([results in disassembly of](http://purl.obolibrary.org/obo/RO_0002590) some [autophagosome membrane](http://purl.obolibrary.org/obo/GO_0000421)) +- [autophagosome membrane disassembly](http://purl.obolibrary.org/obo/GO_0030399) SubClassOf [membrane disassembly](http://purl.obolibrary.org/obo/GO_0030397) -### common dendritic progenitor `http://purl.obolibrary.org/obo/CL_0001029` -#### Removed -- [common dendritic progenitor](http://purl.obolibrary.org/obo/CL_0001029) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [autophagosome membrane disassembly](http://purl.obolibrary.org/obo/GO_0030399) SubClassOf [results in disassembly of](http://purl.obolibrary.org/obo/RO_0002590) some [autophagosome membrane](http://purl.obolibrary.org/obo/GO_0000421) +- [autophagosome membrane disassembly](http://purl.obolibrary.org/obo/GO_0030399) SubClassOf [autophagosome organization](http://purl.obolibrary.org/obo/GO_1905037) -### common myeloid progenitor, CD34-positive `http://purl.obolibrary.org/obo/CL_0001059` + +### autophagosome organization `http://purl.obolibrary.org/obo/GO_1905037` #### Removed -- [common myeloid progenitor, CD34-positive](http://purl.obolibrary.org/obo/CL_0001059) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [autophagosome organization](http://purl.obolibrary.org/obo/GO_1905037) [label](http://www.w3.org/2000/01/rdf-schema#label) "autophagosome organization" +- [autophagosome organization](http://purl.obolibrary.org/obo/GO_1905037) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:1905037" +- [autophagosome organization](http://purl.obolibrary.org/obo/GO_1905037) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "autophagic vacuole organization" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" -### complement component C1q receptor `http://purl.obolibrary.org/obo/PR_000002037` +- [autophagosome organization](http://purl.obolibrary.org/obo/GO_1905037) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an autophagosome." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:bf" -#### Added -- [complement component C1q receptor](http://purl.obolibrary.org/obo/PR_000002037) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [complement component C1q receptor (human)](http://purl.obolibrary.org/obo/PR_Q9NPY3) + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:PARL" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" -### complement receptor type 1 `http://purl.obolibrary.org/obo/PR_000001337` + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:22186024" -#### Added -- [complement receptor type 1](http://purl.obolibrary.org/obo/PR_000001337) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [complement receptor type 1 (human)](http://purl.obolibrary.org/obo/PR_P17927) +- [autophagosome organization](http://purl.obolibrary.org/obo/GO_1905037) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "initial autophagic vacuole organization" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" +- [autophagosome organization](http://purl.obolibrary.org/obo/GO_1905037) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" -### complement receptor type 2 `http://purl.obolibrary.org/obo/PR_000001338` +- [autophagosome organization](http://purl.obolibrary.org/obo/GO_1905037) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2016-03-08T14:18:10Z" -#### Added -- [complement receptor type 2](http://purl.obolibrary.org/obo/PR_000001338) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [complement receptor type 2 (human)](http://purl.obolibrary.org/obo/PR_P20023) +- [autophagosome organization](http://purl.obolibrary.org/obo/GO_1905037) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "bf" +- Class: [autophagosome organization](http://purl.obolibrary.org/obo/GO_1905037) -### conceptus `http://purl.obolibrary.org/obo/UBERON_0004716` -#### Removed -- [conceptus](http://purl.obolibrary.org/obo/UBERON_0004716) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [autophagosome organization](http://purl.obolibrary.org/obo/GO_1905037) EquivalentTo [cellular component organization](http://purl.obolibrary.org/obo/GO_0016043) and ([results in organization of](http://purl.obolibrary.org/obo/RO_0002592) some [autophagosome](http://purl.obolibrary.org/obo/GO_0005776)) +- [autophagosome organization](http://purl.obolibrary.org/obo/GO_1905037) SubClassOf [results in organization of](http://purl.obolibrary.org/obo/RO_0002592) some [autophagosome](http://purl.obolibrary.org/obo/GO_0005776) +- [autophagosome organization](http://purl.obolibrary.org/obo/GO_1905037) SubClassOf [vacuole organization](http://purl.obolibrary.org/obo/GO_0007033) -### conjunctiva `http://purl.obolibrary.org/obo/UBERON_0001811` -#### Removed -- [conjunctiva](http://purl.obolibrary.org/obo/UBERON_0001811) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [autophagosome organization](http://purl.obolibrary.org/obo/GO_1905037) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [macroautophagy](http://purl.obolibrary.org/obo/GO_0016236) -### connecting stalk `http://purl.obolibrary.org/obo/UBERON_0007806` +### autophagy `http://purl.obolibrary.org/obo/GO_0006914` #### Removed -- [connecting stalk](http://purl.obolibrary.org/obo/UBERON_0007806) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) - - +- [autophagy](http://purl.obolibrary.org/obo/GO_0006914) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [goslim_generic](http://purl.obolibrary.org/obo/go#goslim_generic) -### connecting stalk vasculature `http://purl.obolibrary.org/obo/UBERON_0007807` -#### Removed -- [connecting stalk vasculature](http://purl.obolibrary.org/obo/UBERON_0007807) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [autophagy](http://purl.obolibrary.org/obo/GO_0006914) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [goslim_chembl](http://purl.obolibrary.org/obo/go#goslim_chembl) +- [autophagy](http://purl.obolibrary.org/obo/GO_0006914) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [goslim_drosophila](http://purl.obolibrary.org/obo/go#goslim_drosophila) +- [autophagy](http://purl.obolibrary.org/obo/GO_0006914) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" -### conventional dendritic cell `http://purl.obolibrary.org/obo/CL_0000990` -#### Removed -- [conventional dendritic cell](http://purl.obolibrary.org/obo/CL_0000990) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [autophagy](http://purl.obolibrary.org/obo/GO_0006914) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0006914" +- [autophagy](http://purl.obolibrary.org/obo/GO_0006914) [has_alternative_id](http://www.geneontology.org/formats/oboInOwl#hasAlternativeId) "GO:0016238" +- [autophagy](http://purl.obolibrary.org/obo/GO_0006914) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [goslim_pir](http://purl.obolibrary.org/obo/go#goslim_pir) -### cornea `http://purl.obolibrary.org/obo/UBERON_0000964` -#### Removed -- [cornea](http://purl.obolibrary.org/obo/UBERON_0000964) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [autophagy](http://purl.obolibrary.org/obo/GO_0006914) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [goslim_pombe](http://purl.obolibrary.org/obo/go#goslim_pombe) +- [autophagy](http://purl.obolibrary.org/obo/GO_0006914) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The cellular catabolic process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:11099404" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:9412464" -### corneal epithelium `http://purl.obolibrary.org/obo/UBERON_0001772` -#### Removed -- [corneal epithelium](http://purl.obolibrary.org/obo/UBERON_0001772) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:autophagy" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ISBN:0198547684" +- [autophagy](http://purl.obolibrary.org/obo/GO_0006914) [label](http://www.w3.org/2000/01/rdf-schema#label) "autophagy" -### corneocyte `http://purl.obolibrary.org/obo/CL_0002153` -#### Removed -- [corneocyte](http://purl.obolibrary.org/obo/CL_0002153) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [autophagy](http://purl.obolibrary.org/obo/GO_0006914) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Wikipedia:Autophagy_(cellular)" +- Class: [autophagy](http://purl.obolibrary.org/obo/GO_0006914) +- [autophagy](http://purl.obolibrary.org/obo/GO_0006914) SubClassOf [process utilizing autophagic mechanism](http://purl.obolibrary.org/obo/GO_0061919) -### correlated with `http://purl.obolibrary.org/obo/RO_0002610` +- [autophagy](http://purl.obolibrary.org/obo/GO_0006914) SubClassOf [cellular catabolic process](http://purl.obolibrary.org/obo/GO_0044248) -#### Added -- [correlated with](http://purl.obolibrary.org/obo/RO_0002610) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A relationship that holds between two entities, where the entities exhibit a statistical dependence relationship. The entities may be statistical variables, or they may be other kinds of entities such as diseases, chemical entities or processes." +- [autophagy](http://purl.obolibrary.org/obo/GO_0006914) SubClassOf [only in taxon](http://purl.obolibrary.org/obo/RO_0002160) some [Eukaryota](http://purl.obolibrary.org/obo/NCBITaxon_2759) -- [correlated with](http://purl.obolibrary.org/obo/RO_0002610) [IAO_0000232](http://purl.obolibrary.org/obo/IAO_0000232) "Groups both positive and negative correlation" +- [autophagy](http://purl.obolibrary.org/obo/GO_0006914) SubClassOf [ends with](http://purl.obolibrary.org/obo/RO_0002230) some [transmembrane transport](http://purl.obolibrary.org/obo/GO_0055085) -- [correlated with](http://purl.obolibrary.org/obo/RO_0002610) [label](http://www.w3.org/2000/01/rdf-schema#label) "correlated with" +- [autophagy](http://purl.obolibrary.org/obo/GO_0006914) SubClassOf [in taxon](http://purl.obolibrary.org/obo/RO_0002162) only [Eukaryota](http://purl.obolibrary.org/obo/NCBITaxon_2759) -- ObjectProperty: [correlated with](http://purl.obolibrary.org/obo/RO_0002610) -### cortex of thymus `http://purl.obolibrary.org/obo/UBERON_0002123` -#### Removed -- [cortex of thymus](http://purl.obolibrary.org/obo/UBERON_0002123) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +### basic amino acid transmembrane export from vacuole `http://purl.obolibrary.org/obo/GO_0034488` +#### Added +- [basic amino acid transmembrane export from vacuole](http://purl.obolibrary.org/obo/GO_0034488) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0034488" +- [basic amino acid transmembrane export from vacuole](http://purl.obolibrary.org/obo/GO_0034488) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The directed movement of basic amino acids out of the vacuole, across the vacuolar membrane." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:mah" -### cortical intermediate zone `http://purl.obolibrary.org/obo/UBERON_0004040` -#### Removed -- [cortical intermediate zone](http://purl.obolibrary.org/obo/UBERON_0004040) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [basic amino acid transmembrane export from vacuole](http://purl.obolibrary.org/obo/GO_0034488) [label](http://www.w3.org/2000/01/rdf-schema#label) "basic amino acid transmembrane export from vacuole" +- [basic amino acid transmembrane export from vacuole](http://purl.obolibrary.org/obo/GO_0034488) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" +- Class: [basic amino acid transmembrane export from vacuole](http://purl.obolibrary.org/obo/GO_0034488) -### cortical layer I `http://purl.obolibrary.org/obo/UBERON_0005390` -#### Removed -- [cortical layer I](http://purl.obolibrary.org/obo/UBERON_0005390) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [basic amino acid transmembrane export from vacuole](http://purl.obolibrary.org/obo/GO_0034488) EquivalentTo [basic amino acid transport](http://purl.obolibrary.org/obo/GO_0015802) and ([has target start location](http://purl.obolibrary.org/obo/RO_0002338) some [vacuolar lumen](http://purl.obolibrary.org/obo/GO_0005775)) and ([has target end location](http://purl.obolibrary.org/obo/RO_0002339) some [cytosol](http://purl.obolibrary.org/obo/GO_0005829)) and ([results in transport across](http://purl.obolibrary.org/obo/RO_0002342) some [vacuolar membrane](http://purl.obolibrary.org/obo/GO_0005774)) +- [basic amino acid transmembrane export from vacuole](http://purl.obolibrary.org/obo/GO_0034488) SubClassOf [basic amino acid transmembrane transport](http://purl.obolibrary.org/obo/GO_1990822) +- [basic amino acid transmembrane export from vacuole](http://purl.obolibrary.org/obo/GO_0034488) SubClassOf [amino acid transmembrane export from vacuole](http://purl.obolibrary.org/obo/GO_0032974) -### cortical layer II `http://purl.obolibrary.org/obo/UBERON_0005391` -#### Removed -- [cortical layer II](http://purl.obolibrary.org/obo/UBERON_0005391) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [basic amino acid transmembrane export from vacuole](http://purl.obolibrary.org/obo/GO_0034488) SubClassOf [vacuolar amino acid transmembrane transport](http://purl.obolibrary.org/obo/GO_0034487) +### basic amino acid transmembrane import into vacuole `http://purl.obolibrary.org/obo/GO_0034490` -### cortical layer III `http://purl.obolibrary.org/obo/UBERON_0005392` -#### Removed -- [cortical layer III](http://purl.obolibrary.org/obo/UBERON_0005392) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +#### Added +- [basic amino acid transmembrane import into vacuole](http://purl.obolibrary.org/obo/GO_0034490) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0034490" +- [basic amino acid transmembrane import into vacuole](http://purl.obolibrary.org/obo/GO_0034490) [label](http://www.w3.org/2000/01/rdf-schema#label) "basic amino acid transmembrane import into vacuole" +- [basic amino acid transmembrane import into vacuole](http://purl.obolibrary.org/obo/GO_0034490) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The directed movement of basic amino acids into the vacuole across the vacuolar membrane." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:mah" -### cortical layer IV `http://purl.obolibrary.org/obo/UBERON_0005393` -#### Removed -- [cortical layer IV](http://purl.obolibrary.org/obo/UBERON_0005393) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [basic amino acid transmembrane import into vacuole](http://purl.obolibrary.org/obo/GO_0034490) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" +- Class: [basic amino acid transmembrane import into vacuole](http://purl.obolibrary.org/obo/GO_0034490) +- [basic amino acid transmembrane import into vacuole](http://purl.obolibrary.org/obo/GO_0034490) EquivalentTo [basic amino acid transport](http://purl.obolibrary.org/obo/GO_0015802) and ([has target start location](http://purl.obolibrary.org/obo/RO_0002338) some [cytosol](http://purl.obolibrary.org/obo/GO_0005829)) and ([has target end location](http://purl.obolibrary.org/obo/RO_0002339) some [vacuolar lumen](http://purl.obolibrary.org/obo/GO_0005775)) and ([results in transport across](http://purl.obolibrary.org/obo/RO_0002342) some [membrane](http://purl.obolibrary.org/obo/GO_0016020)) and ([has primary input](http://purl.obolibrary.org/obo/RO_0004009) some [CHEBI_33709](http://purl.obolibrary.org/obo/CHEBI_33709)) -### cortical layer V `http://purl.obolibrary.org/obo/UBERON_0005394` -#### Removed -- [cortical layer V](http://purl.obolibrary.org/obo/UBERON_0005394) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [basic amino acid transmembrane import into vacuole](http://purl.obolibrary.org/obo/GO_0034490) SubClassOf [amino acid transmembrane import into vacuole](http://purl.obolibrary.org/obo/GO_0032975) +- [basic amino acid transmembrane import into vacuole](http://purl.obolibrary.org/obo/GO_0034490) SubClassOf [basic amino acid transmembrane transport](http://purl.obolibrary.org/obo/GO_1990822) -### cortical layer VIb `http://purl.obolibrary.org/obo/UBERON_8440003` +### bistratified retinal amacrine cell `http://purl.obolibrary.org/obo/CL_0004250` #### Removed -- [cortical layer VIb](http://purl.obolibrary.org/obo/UBERON_8440003) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [bistratified retinal amacrine cell](http://purl.obolibrary.org/obo/CL_0004250) SubClassOf [retina horizontal cell](http://purl.obolibrary.org/obo/CL_0000745) -### cortical plate `http://purl.obolibrary.org/obo/UBERON_0005343` +### bone marrow macrophage `http://purl.obolibrary.org/obo/CL_0002476` #### Removed -- [cortical plate](http://purl.obolibrary.org/obo/UBERON_0005343) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [bone marrow macrophage](http://purl.obolibrary.org/obo/CL_0002476) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "MF.BM" +#### Added +- [bone marrow macrophage](http://purl.obolibrary.org/obo/CL_0002476) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "MF.BM" + - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation) -### cortical subplate `http://purl.obolibrary.org/obo/UBERON_0004035` +### broad diffuse amacrine cell `http://purl.obolibrary.org/obo/CL_0004228` #### Removed -- [cortical subplate](http://purl.obolibrary.org/obo/UBERON_0004035) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [broad diffuse amacrine cell](http://purl.obolibrary.org/obo/CL_0004228) SubClassOf [retina horizontal cell](http://purl.obolibrary.org/obo/CL_0000745) +#### Added +- [broad diffuse amacrine cell](http://purl.obolibrary.org/obo/CL_0004228) SubClassOf [amacrine cell](http://purl.obolibrary.org/obo/CL_0000561) -### corticothalamic VAL/VM projecting glutamatergic neuron of the primary motor cortex `http://purl.obolibrary.org/obo/CL_4023055` +### bronchiole `http://purl.obolibrary.org/obo/UBERON_0002186` +#### Removed +- [bronchiole](http://purl.obolibrary.org/obo/UBERON_0002186) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [pulmonary lobule](http://purl.obolibrary.org/obo/UBERON_0010368) + - [source](http://www.geneontology.org/formats/oboInOwl#source) "ncit" #### Added -- [corticothalamic VAL/VM projecting glutamatergic neuron of the primary motor cortex](http://purl.obolibrary.org/obo/CL_4023055) [symbol](http://purl.obolibrary.org/obo/IAO_0000028) "CT VAL/VM glut MOp" +- [bronchiole](http://purl.obolibrary.org/obo/UBERON_0002186) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [lung](http://purl.obolibrary.org/obo/UBERON_0002048) + - [source](http://www.geneontology.org/formats/oboInOwl#source) "MA" -### corticothalamic-projecting glutamatergic cortical neuron `http://purl.obolibrary.org/obo/CL_4023013` +### bronchopulmonary segment `http://purl.obolibrary.org/obo/UBERON_8600017` #### Added -- [corticothalamic-projecting glutamatergic cortical neuron](http://purl.obolibrary.org/obo/CL_4023013) [symbol](http://purl.obolibrary.org/obo/IAO_0000028) "CT glut" +- [bronchopulmonary segment](http://purl.obolibrary.org/obo/UBERON_8600017) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "uberon" +- [bronchopulmonary segment](http://purl.obolibrary.org/obo/UBERON_8600017) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "A bronchopulmonary segment is surrounded by connective tissue septa, which are continuous with the pleural surface and prevent air collateralization between segments somewhat. In humans, the right lung has ten bronchopulmonary segments and eight or nine bronchopulmonary segments in the left lung." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:18271171" -### cranial nerve `http://purl.obolibrary.org/obo/UBERON_0001785` -#### Removed -- [cranial nerve](http://purl.obolibrary.org/obo/UBERON_0001785) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/j.mpaic.2008.09.022" +- [bronchopulmonary segment](http://purl.obolibrary.org/obo/UBERON_8600017) [contributor](http://purl.org/dc/terms/contributor) [0000-0001-6677-8489](https://orcid.org/0000-0001-6677-8489) +- [bronchopulmonary segment](http://purl.obolibrary.org/obo/UBERON_8600017) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A discrete anatomical unit of the lung that is composed of a segmental bronchus and the lung tissue supplied by that bronchus. A bronchopulmonary segment exhibits a pyramidal shape, with its apex pointing towards the center of the lung and its base toward the pleural surface." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:33620799" -### cranial nerve II `http://purl.obolibrary.org/obo/UBERON_0000941` -#### Removed -- [cranial nerve II](http://purl.obolibrary.org/obo/UBERON_0000941) SubClassOf [neuron projection bundle](http://purl.obolibrary.org/obo/CARO_0001001) + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "FMA:7312" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:18271171" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/j.mpaic.2008.09.022" -### cranial neural crest `http://purl.obolibrary.org/obo/UBERON_0003099` -#### Removed -- [cranial neural crest](http://purl.obolibrary.org/obo/UBERON_0003099) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [bronchopulmonary segment](http://purl.obolibrary.org/obo/UBERON_8600017) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "lung segment" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:33620799" +- [bronchopulmonary segment](http://purl.obolibrary.org/obo/UBERON_8600017) [id](http://www.geneontology.org/formats/oboInOwl#id) "UBERON:8600017" +- [bronchopulmonary segment](http://purl.obolibrary.org/obo/UBERON_8600017) [label](http://www.w3.org/2000/01/rdf-schema#label) "bronchopulmonary segment" -### cranial suture `http://purl.obolibrary.org/obo/UBERON_0003685` -#### Removed -- [cranial suture](http://purl.obolibrary.org/obo/UBERON_0003685) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [bronchopulmonary segment](http://purl.obolibrary.org/obo/UBERON_8600017) [date](http://purl.org/dc/terms/date) "2023-07-20T12:43:29Z"^^[dateTime](http://www.w3.org/2001/XMLSchema#dateTime) +- [bronchopulmonary segment](http://purl.obolibrary.org/obo/UBERON_8600017) [contributor](http://purl.org/dc/terms/contributor) [0000-0002-9185-3994](https://orcid.org/0000-0002-9185-3994) +- Class: [bronchopulmonary segment](http://purl.obolibrary.org/obo/UBERON_8600017) -### crista ampullaris neuroepithelium `http://purl.obolibrary.org/obo/UBERON_0006935` -#### Removed -- [crista ampullaris neuroepithelium](http://purl.obolibrary.org/obo/UBERON_0006935) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [bronchopulmonary segment](http://purl.obolibrary.org/obo/UBERON_8600017) SubClassOf [organ subunit](http://purl.obolibrary.org/obo/UBERON_0000063) +- [bronchopulmonary segment](http://purl.obolibrary.org/obo/UBERON_8600017) SubClassOf [contributes to morphology of](http://purl.obolibrary.org/obo/RO_0002433) some [lobe of lung](http://purl.obolibrary.org/obo/UBERON_0000101) +- [bronchopulmonary segment](http://purl.obolibrary.org/obo/UBERON_8600017) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [lobe of lung](http://purl.obolibrary.org/obo/UBERON_0000101) -### crossSpeciesExactMatch `https://w3id.org/semapv/vocab/crossSpeciesExactMatch` + +### bronchus smooth muscle `http://purl.obolibrary.org/obo/UBERON_0004242` #### Added -- AnnotationProperty: [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) +- [bronchus smooth muscle](http://purl.obolibrary.org/obo/UBERON_0004242) [contributor](http://purl.org/dc/terms/contributor) [0000-0001-6677-8489](https://orcid.org/0000-0001-6677-8489) +- [bronchus smooth muscle](http://purl.obolibrary.org/obo/UBERON_0004242) SubClassOf [has part](http://purl.obolibrary.org/obo/BFO_0000051) some [bronchial smooth muscle cell](http://purl.obolibrary.org/obo/CL_0002598) -### curation status specification `http://purl.obolibrary.org/obo/IAO_0000078` + +### calcium ion export across plasma membrane `http://purl.obolibrary.org/obo/GO_1990034` #### Added -- [curation status specification](http://purl.obolibrary.org/obo/IAO_0000078) [IAO_0000117](http://purl.obolibrary.org/obo/IAO_0000117) "PERSON:Bill Bug"@en +- [calcium ion export across plasma membrane](http://purl.obolibrary.org/obo/GO_1990034) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2013-02-07T13:01:29Z" -- [curation status specification](http://purl.obolibrary.org/obo/IAO_0000078) [IAO_0000114](http://purl.obolibrary.org/obo/IAO_0000114) [pending final vetting](http://purl.obolibrary.org/obo/IAO_0000125) +- [calcium ion export across plasma membrane](http://purl.obolibrary.org/obo/GO_1990034) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" -- [curation status specification](http://purl.obolibrary.org/obo/IAO_0000078) [label](http://www.w3.org/2000/01/rdf-schema#label) "curation status specification"@en +- [calcium ion export across plasma membrane](http://purl.obolibrary.org/obo/GO_1990034) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:1990034" -- [curation status specification](http://purl.obolibrary.org/obo/IAO_0000078) [IAO_0000119](http://purl.obolibrary.org/obo/IAO_0000119) "OBI_0000266"@en +- [calcium ion export across plasma membrane](http://purl.obolibrary.org/obo/GO_1990034) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "mah" -- [curation status specification](http://purl.obolibrary.org/obo/IAO_0000078) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The curation status of the term. The allowed values come from an enumerated list of predefined terms. See the specification of these instances for more detailed definitions of each enumerated value."@en +- [calcium ion export across plasma membrane](http://purl.obolibrary.org/obo/GO_1990034) [label](http://www.w3.org/2000/01/rdf-schema#label) "calcium ion export across plasma membrane" -- [curation status specification](http://purl.obolibrary.org/obo/IAO_0000078) [IAO_0000119](http://purl.obolibrary.org/obo/IAO_0000119) "GROUP:OBI:<http://purl.obolibrary.org/obo/obi>"@en +- [calcium ion export across plasma membrane](http://purl.obolibrary.org/obo/GO_1990034) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "calcium ion export from cell" -- [curation status specification](http://purl.obolibrary.org/obo/IAO_0000078) [editor note](http://purl.obolibrary.org/obo/IAO_0000116) "Better to represent curation as a process with parts and then relate labels to that process (in IAO meeting)"@en +- [calcium ion export across plasma membrane](http://purl.obolibrary.org/obo/GO_1990034) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "calcium ion efflux from cell" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:vw" -- [curation status specification](http://purl.obolibrary.org/obo/IAO_0000078) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "curation status specification"@en + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:2145281" -- Class: [curation status specification](http://purl.obolibrary.org/obo/IAO_0000078) +- [calcium ion export across plasma membrane](http://purl.obolibrary.org/obo/GO_1990034) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The directed movement of calcium ions from inside of a cell, across the plasma membrane and into the extracellular region." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:mah" -- [curation status specification](http://purl.obolibrary.org/obo/IAO_0000078) EquivalentTo {[example to be eventually removed](http://purl.obolibrary.org/obo/IAO_0000002) , [metadata complete](http://purl.obolibrary.org/obo/IAO_0000120) , [organizational term](http://purl.obolibrary.org/obo/IAO_0000121) , [ready for release](http://purl.obolibrary.org/obo/IAO_0000122) , [metadata incomplete](http://purl.obolibrary.org/obo/IAO_0000123) , [uncurated](http://purl.obolibrary.org/obo/IAO_0000124) , [pending final vetting](http://purl.obolibrary.org/obo/IAO_0000125) , [to be replaced with external ontology term](http://purl.obolibrary.org/obo/IAO_0000423) , [requires discussion](http://purl.obolibrary.org/obo/IAO_0000428)} + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:2145281" -- [curation status specification](http://purl.obolibrary.org/obo/IAO_0000078) SubClassOf [data about an ontology part](http://purl.obolibrary.org/obo/IAO_0000102) +- Class: [calcium ion export across plasma membrane](http://purl.obolibrary.org/obo/GO_1990034) +- [calcium ion export across plasma membrane](http://purl.obolibrary.org/obo/GO_1990034) EquivalentTo [transport](http://purl.obolibrary.org/obo/GO_0006810) and ([has target start location](http://purl.obolibrary.org/obo/RO_0002338) some [cytosol](http://purl.obolibrary.org/obo/GO_0005829)) and ([has target end location](http://purl.obolibrary.org/obo/RO_0002339) some [extracellular region](http://purl.obolibrary.org/obo/GO_0005576)) and ([results in transport across](http://purl.obolibrary.org/obo/RO_0002342) some [plasma membrane](http://purl.obolibrary.org/obo/GO_0005886)) and ([has primary input](http://purl.obolibrary.org/obo/RO_0004009) some [CHEBI_29108](http://purl.obolibrary.org/obo/CHEBI_29108)) -### cutaneous appendage `http://purl.obolibrary.org/obo/UBERON_0000021` -#### Removed -- [cutaneous appendage](http://purl.obolibrary.org/obo/UBERON_0000021) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000) +- [calcium ion export across plasma membrane](http://purl.obolibrary.org/obo/GO_1990034) SubClassOf [export across plasma membrane](http://purl.obolibrary.org/obo/GO_0140115) +- [calcium ion export across plasma membrane](http://purl.obolibrary.org/obo/GO_1990034) SubClassOf [calcium ion transmembrane transport](http://purl.obolibrary.org/obo/GO_0070588) -### cyanophore `http://purl.obolibrary.org/obo/CL_0000747` -#### Removed -- [cyanophore](http://purl.obolibrary.org/obo/CL_0000747) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +### calcium ion import across plasma membrane `http://purl.obolibrary.org/obo/GO_0098703` +#### Added +- [calcium ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098703) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2013-02-07T13:07:59Z" +- [calcium ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098703) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "calcium ion import into cell" -### cytotoxic T-lymphocyte protein 4 `http://purl.obolibrary.org/obo/PR_000001852` +- [calcium ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098703) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "mah" -#### Added -- [cytotoxic T-lymphocyte protein 4](http://purl.obolibrary.org/obo/PR_000001852) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [cytotoxic T-lymphocyte protein 4 (human)](http://purl.obolibrary.org/obo/PR_P16410) +- [calcium ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098703) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0098703" +- [calcium ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098703) [has_alternative_id](http://www.geneontology.org/formats/oboInOwl#hasAlternativeId) "GO:1990035" -### data about an ontology part `http://purl.obolibrary.org/obo/IAO_0000102` +- [calcium ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098703) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" -#### Added -- [data about an ontology part](http://purl.obolibrary.org/obo/IAO_0000102) [IAO_0000117](http://purl.obolibrary.org/obo/IAO_0000117) "Person:Alan Ruttenberg"@en +- [calcium ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098703) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The directed movement of calcium ions from outside of a cell, across the plasma membrane and into the cytosol." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dos" -- [data about an ontology part](http://purl.obolibrary.org/obo/IAO_0000102) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Data about an ontology part is a data item about a part of an ontology, for example a term"@en +- [calcium ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098703) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "calcium ion uptake into cell" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:vw" -- [data about an ontology part](http://purl.obolibrary.org/obo/IAO_0000102) [label](http://www.w3.org/2000/01/rdf-schema#label) "data about an ontology part"@en +- [calcium ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098703) [label](http://www.w3.org/2000/01/rdf-schema#label) "calcium ion import across plasma membrane" -- [data about an ontology part](http://purl.obolibrary.org/obo/IAO_0000102) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "data about an ontology part"@en +- Class: [calcium ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098703) -- Class: [data about an ontology part](http://purl.obolibrary.org/obo/IAO_0000102) +- [calcium ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098703) EquivalentTo [transport](http://purl.obolibrary.org/obo/GO_0006810) and ([has target start location](http://purl.obolibrary.org/obo/RO_0002338) some [extracellular region](http://purl.obolibrary.org/obo/GO_0005576)) and ([has target end location](http://purl.obolibrary.org/obo/RO_0002339) some [cytosol](http://purl.obolibrary.org/obo/GO_0005829)) and ([results in transport across](http://purl.obolibrary.org/obo/RO_0002342) some [plasma membrane](http://purl.obolibrary.org/obo/GO_0005886)) and ([has primary input](http://purl.obolibrary.org/obo/RO_0004009) some [CHEBI_29108](http://purl.obolibrary.org/obo/CHEBI_29108)) -- [data about an ontology part](http://purl.obolibrary.org/obo/IAO_0000102) SubClassOf [data item](http://purl.obolibrary.org/obo/IAO_0000027) +- [calcium ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098703) SubClassOf [calcium ion transmembrane import into cytosol](http://purl.obolibrary.org/obo/GO_0097553) +- [calcium ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098703) SubClassOf [import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098739) -### data item `http://purl.obolibrary.org/obo/IAO_0000027` -#### Added -- [data item](http://purl.obolibrary.org/obo/IAO_0000027) [IAO_0000117](http://purl.obolibrary.org/obo/IAO_0000117) "PERSON: Alan Ruttenberg"@en +### calcium ion import into vacuole `http://purl.obolibrary.org/obo/GO_0140146` -- [data item](http://purl.obolibrary.org/obo/IAO_0000027) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "An information content entity that is intended to be a truthful statement about something (modulo, e.g., measurement precision or other systematic errors) and is constructed/acquired by a method which reliably tends to produce (approximately) truthful statements."@en +#### Added +- [calcium ion import into vacuole](http://purl.obolibrary.org/obo/GO_0140146) [label](http://www.w3.org/2000/01/rdf-schema#label) "calcium ion import into vacuole" -- [data item](http://purl.obolibrary.org/obo/IAO_0000027) [IAO_0000112](http://purl.obolibrary.org/obo/IAO_0000112) "Data items include counts of things, analyte concentrations, and statistical summaries."@en +- [calcium ion import into vacuole](http://purl.obolibrary.org/obo/GO_0140146) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" -- [data item](http://purl.obolibrary.org/obo/IAO_0000027) [label](http://www.w3.org/2000/01/rdf-schema#label) "data item"@en +- [calcium ion import into vacuole](http://purl.obolibrary.org/obo/GO_0140146) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The directed movement of calcium cations into the vacuole across the vacuolar membrane." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:vw" -- [data item](http://purl.obolibrary.org/obo/IAO_0000027) [IAO_0000117](http://purl.obolibrary.org/obo/IAO_0000117) "PERSON: Jonathan Rees"@en + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:8628289" -- [data item](http://purl.obolibrary.org/obo/IAO_0000027) [IAO_0000118](http://purl.obolibrary.org/obo/IAO_0000118) "data"@en +- [calcium ion import into vacuole](http://purl.obolibrary.org/obo/GO_0140146) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2017-12-13T15:15:29Z" -- [data item](http://purl.obolibrary.org/obo/IAO_0000027) [editor note](http://purl.obolibrary.org/obo/IAO_0000116) "2009-03-16: data item deliberatly ambiguous: we merged data set and datum to be one entity, not knowing how to define singular versus plural. So data item is more general than datum."@en +- [calcium ion import into vacuole](http://purl.obolibrary.org/obo/GO_0140146) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0140146" -- [data item](http://purl.obolibrary.org/obo/IAO_0000027) [editor note](http://purl.obolibrary.org/obo/IAO_0000116) "2009-03-16: removed datum as alternative term as datum specifically refers to singular form, and is thus not an exact synonym."@en +- [calcium ion import into vacuole](http://purl.obolibrary.org/obo/GO_0140146) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "pg" -- [data item](http://purl.obolibrary.org/obo/IAO_0000027) [editor note](http://purl.obolibrary.org/obo/IAO_0000116) "JAR: datum -- well, this will be very tricky to define, but maybe some -information-like stuff that might be put into a computer and that is -meant, by someone, to denote and/or to be interpreted by some -process... I would include lists, tables, sentences... I think I might -defer to Barry, or to Brian Cantwell Smith +- Class: [calcium ion import into vacuole](http://purl.obolibrary.org/obo/GO_0140146) -JAR: A data item is an approximately justified approximately true approximate belief"@en +- [calcium ion import into vacuole](http://purl.obolibrary.org/obo/GO_0140146) EquivalentTo [transport](http://purl.obolibrary.org/obo/GO_0006810) and ([has target start location](http://purl.obolibrary.org/obo/RO_0002338) some [cytosol](http://purl.obolibrary.org/obo/GO_0005829)) and ([has target end location](http://purl.obolibrary.org/obo/RO_0002339) some [vacuolar lumen](http://purl.obolibrary.org/obo/GO_0005775)) and ([results in transport across](http://purl.obolibrary.org/obo/RO_0002342) some [vacuolar membrane](http://purl.obolibrary.org/obo/GO_0005774)) and ([has primary input](http://purl.obolibrary.org/obo/RO_0004009) some [CHEBI_29108](http://purl.obolibrary.org/obo/CHEBI_29108)) -- [data item](http://purl.obolibrary.org/obo/IAO_0000027) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "data item"@en +- [calcium ion import into vacuole](http://purl.obolibrary.org/obo/GO_0140146) SubClassOf [has target start location](http://purl.obolibrary.org/obo/RO_0002338) some [cytosol](http://purl.obolibrary.org/obo/GO_0005829) -- [data item](http://purl.obolibrary.org/obo/IAO_0000027) [editor note](http://purl.obolibrary.org/obo/IAO_0000116) "2/2/2009 Alan and Bjoern discussing FACS run output data. This is a data item because it is about the cell population. Each element records an event and is typically further composed a set of measurment data items that record the fluorescent intensity stimulated by one of the lasers."@en +- [calcium ion import into vacuole](http://purl.obolibrary.org/obo/GO_0140146) SubClassOf [vacuolar transmembrane transport](http://purl.obolibrary.org/obo/GO_0034486) -- [data item](http://purl.obolibrary.org/obo/IAO_0000027) [IAO_0000117](http://purl.obolibrary.org/obo/IAO_0000117) "PERSON: Chris Stoeckert"@en +- [calcium ion import into vacuole](http://purl.obolibrary.org/obo/GO_0140146) SubClassOf [has target end location](http://purl.obolibrary.org/obo/RO_0002339) some [vacuolar lumen](http://purl.obolibrary.org/obo/GO_0005775) -- [data item](http://purl.obolibrary.org/obo/IAO_0000027) [editor note](http://purl.obolibrary.org/obo/IAO_0000116) "2014-03-31: See discussion at http://odontomachus.wordpress.com/2014/03/30/aboutness-objects-propositions/" +- [calcium ion import into vacuole](http://purl.obolibrary.org/obo/GO_0140146) SubClassOf [results in transport across](http://purl.obolibrary.org/obo/RO_0002342) some [vacuolar membrane](http://purl.obolibrary.org/obo/GO_0005774) -- [data item](http://purl.obolibrary.org/obo/IAO_0000027) [IAO_0000114](http://purl.obolibrary.org/obo/IAO_0000114) [pending final vetting](http://purl.obolibrary.org/obo/IAO_0000125) +- [calcium ion import into vacuole](http://purl.obolibrary.org/obo/GO_0140146) SubClassOf [calcium ion transmembrane transport](http://purl.obolibrary.org/obo/GO_0070588) -- Class: [data item](http://purl.obolibrary.org/obo/IAO_0000027) -- [data item](http://purl.obolibrary.org/obo/IAO_0000027) SubClassOf [information content entity](http://purl.obolibrary.org/obo/IAO_0000030) +### calcium ion transmembrane import into cytosol `http://purl.obolibrary.org/obo/GO_0097553` +#### Added +- [calcium ion transmembrane import into cytosol](http://purl.obolibrary.org/obo/GO_0097553) [has_alternative_id](http://www.geneontology.org/formats/oboInOwl#hasAlternativeId) "GO:0060401" -### decidua `http://purl.obolibrary.org/obo/UBERON_0002450` -#### Removed -- [decidua](http://purl.obolibrary.org/obo/UBERON_0002450) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [calcium ion transmembrane import into cytosol](http://purl.obolibrary.org/obo/GO_0097553) [label](http://www.w3.org/2000/01/rdf-schema#label) "calcium ion transmembrane import into cytosol" +- [calcium ion transmembrane import into cytosol](http://purl.obolibrary.org/obo/GO_0097553) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "calcium transmembrane import into cytosol" +- [calcium ion transmembrane import into cytosol](http://purl.obolibrary.org/obo/GO_0097553) [term tracker item](http://purl.obolibrary.org/obo/IAO_0000233) "https://github.com/geneontology/go-ontology/issues/23015"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI) -### decidual natural killer cell, human `http://purl.obolibrary.org/obo/CL_0002343` -#### Removed -- [decidual natural killer cell, human](http://purl.obolibrary.org/obo/CL_0002343) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [calcium ion transmembrane import into cytosol](http://purl.obolibrary.org/obo/GO_0097553) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0097553" +- [calcium ion transmembrane import into cytosol](http://purl.obolibrary.org/obo/GO_0097553) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A process in which a calcium ion is transported from one side of a membrane to the other into the cytosol by means of some agent such as a transporter or pore." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:vw" +- [calcium ion transmembrane import into cytosol](http://purl.obolibrary.org/obo/GO_0097553) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" -### defined class `http://purl.obolibrary.org/obo/IAO_0000420` +- [calcium ion transmembrane import into cytosol](http://purl.obolibrary.org/obo/GO_0097553) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2014-01-23T11:05:13Z" -#### Added -- [defined class](http://purl.obolibrary.org/obo/IAO_0000420) [IAO_0000117](http://purl.obolibrary.org/obo/IAO_0000117) "Alan Ruttenberg"@en +- [calcium ion transmembrane import into cytosol](http://purl.obolibrary.org/obo/GO_0097553) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "cytosolic calcium ion transport" -- [defined class](http://purl.obolibrary.org/obo/IAO_0000420) [editor note](http://purl.obolibrary.org/obo/IAO_0000116) ""definitions", in some readings, always are given by necessary and sufficient conditions. So one must be careful (and this is difficult sometimes) to distinguish between defined classes and universal."@en +- [calcium ion transmembrane import into cytosol](http://purl.obolibrary.org/obo/GO_0097553) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "pr" -- [defined class](http://purl.obolibrary.org/obo/IAO_0000420) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "defined class"@en +- Class: [calcium ion transmembrane import into cytosol](http://purl.obolibrary.org/obo/GO_0097553) -- [defined class](http://purl.obolibrary.org/obo/IAO_0000420) [label](http://www.w3.org/2000/01/rdf-schema#label) "defined class"@en +- [calcium ion transmembrane import into cytosol](http://purl.obolibrary.org/obo/GO_0097553) EquivalentTo [transport](http://purl.obolibrary.org/obo/GO_0006810) and ([has target end location](http://purl.obolibrary.org/obo/RO_0002339) some [cytosol](http://purl.obolibrary.org/obo/GO_0005829)) and ([results in transport across](http://purl.obolibrary.org/obo/RO_0002342) some [membrane](http://purl.obolibrary.org/obo/GO_0016020)) and ([has primary input](http://purl.obolibrary.org/obo/RO_0004009) some [CHEBI_29108](http://purl.obolibrary.org/obo/CHEBI_29108)) -- [defined class](http://purl.obolibrary.org/obo/IAO_0000420) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A defined class is a class that is defined by a set of logically necessary and sufficient conditions but is not a universal"@en +- [calcium ion transmembrane import into cytosol](http://purl.obolibrary.org/obo/GO_0097553) SubClassOf [calcium ion transmembrane transport](http://purl.obolibrary.org/obo/GO_0070588) -- Individual: [defined class](http://purl.obolibrary.org/obo/IAO_0000420) +- [calcium ion transmembrane import into cytosol](http://purl.obolibrary.org/obo/GO_0097553) SubClassOf [has target end location](http://purl.obolibrary.org/obo/RO_0002339) some [cytosol](http://purl.obolibrary.org/obo/GO_0005829) -### definition `http://purl.obolibrary.org/obo/IAO_0000115` +### calcium-mediated signaling using extracellular calcium source `http://purl.obolibrary.org/obo/GO_0035585` #### Added -- [definition](http://purl.obolibrary.org/obo/IAO_0000115) [IAO_0000114](http://purl.obolibrary.org/obo/IAO_0000114) [ready for release](http://purl.obolibrary.org/obo/IAO_0000122) +- [calcium-mediated signaling using extracellular calcium source](http://purl.obolibrary.org/obo/GO_0035585) [label](http://www.w3.org/2000/01/rdf-schema#label) "calcium-mediated signaling using extracellular calcium source" -- [definition](http://purl.obolibrary.org/obo/IAO_0000115) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "definition"@en +- [calcium-mediated signaling using extracellular calcium source](http://purl.obolibrary.org/obo/GO_0035585) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "calcium-mediated signalling using extracellular calcium source" -- [definition](http://purl.obolibrary.org/obo/IAO_0000115) [editor note](http://purl.obolibrary.org/obo/IAO_0000116) "2012-04-05: -Barry Smith +- [calcium-mediated signaling using extracellular calcium source](http://purl.obolibrary.org/obo/GO_0035585) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The series of molecular signals in which a cell uses calcium ions imported from an extracellular source to convert a signal into a response." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:bf" -The official OBI definition, explaining the meaning of a class or property: 'Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions' is terrible. + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:20192754" -Can you fix to something like: + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:BHF" -A statement of necessary and sufficient conditions explaining the meaning of an expression referring to a class or property. +- [calcium-mediated signaling using extracellular calcium source](http://purl.obolibrary.org/obo/GO_0035585) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "extracellular calcium influx" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:BHF" -Alan Ruttenberg +- [calcium-mediated signaling using extracellular calcium source](http://purl.obolibrary.org/obo/GO_0035585) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" -Your proposed definition is a reasonable candidate, except that it is very common that necessary and sufficient conditions are not given. Mostly they are necessary, occasionally they are necessary and sufficient or just sufficient. Often they use terms that are not themselves defined and so they effectively can't be evaluated by those criteria. +- [calcium-mediated signaling using extracellular calcium source](http://purl.obolibrary.org/obo/GO_0035585) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "calcium signalling using extracellular calcium source" -On the specifics of the proposed definition: +- [calcium-mediated signaling using extracellular calcium source](http://purl.obolibrary.org/obo/GO_0035585) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2010-10-18T11:04:27Z" -We don't have definitions of 'meaning' or 'expression' or 'property'. For 'reference' in the intended sense I think we use the term 'denotation'. For 'expression', I think we you mean symbol, or identifier. For 'meaning' it differs for class and property. For class we want documentation that let's the intended reader determine whether an entity is instance of the class, or not. For property we want documentation that let's the intended reader determine, given a pair of potential relata, whether the assertion that the relation holds is true. The 'intended reader' part suggests that we also specify who, we expect, would be able to understand the definition, and also generalizes over human and computer reader to include textual and logical definition. +- [calcium-mediated signaling using extracellular calcium source](http://purl.obolibrary.org/obo/GO_0035585) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "bf" -Personally, I am more comfortable weakening definition to documentation, with instructions as to what is desirable. +- [calcium-mediated signaling using extracellular calcium source](http://purl.obolibrary.org/obo/GO_0035585) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0035585" -We also have the outstanding issue of how to aim different definitions to different audiences. A clinical audience reading chebi wants a different sort of definition documentation/definition from a chemistry trained audience, and similarly there is a need for a definition that is adequate for an ontologist to work with. "@en +- [calcium-mediated signaling using extracellular calcium source](http://purl.obolibrary.org/obo/GO_0035585) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "calcium signaling using extracellular calcium source" -- [definition](http://purl.obolibrary.org/obo/IAO_0000115) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The official definition, explaining the meaning of a class or property. Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions."@en +- Class: [calcium-mediated signaling using extracellular calcium source](http://purl.obolibrary.org/obo/GO_0035585) -- [definition](http://purl.obolibrary.org/obo/IAO_0000115) [label](http://www.w3.org/2000/01/rdf-schema#label) "definition"@en +- [calcium-mediated signaling using extracellular calcium source](http://purl.obolibrary.org/obo/GO_0035585) EquivalentTo [calcium-mediated signaling](http://purl.obolibrary.org/obo/GO_0019722) and ([starts with](http://purl.obolibrary.org/obo/RO_0002224) some [calcium ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098703)) -- [definition](http://purl.obolibrary.org/obo/IAO_0000115) [isDefinedBy](http://www.w3.org/2000/01/rdf-schema#isDefinedBy) [iao.owl](http://purl.obolibrary.org/obo/iao.owl) +- [calcium-mediated signaling using extracellular calcium source](http://purl.obolibrary.org/obo/GO_0035585) SubClassOf [calcium-mediated signaling](http://purl.obolibrary.org/obo/GO_0019722) -- [definition](http://purl.obolibrary.org/obo/IAO_0000115) [IAO_0000119](http://purl.obolibrary.org/obo/IAO_0000119) "GROUP:OBI:<http://purl.obolibrary.org/obo/obi>"@en +- [calcium-mediated signaling using extracellular calcium source](http://purl.obolibrary.org/obo/GO_0035585) SubClassOf [starts with](http://purl.obolibrary.org/obo/RO_0002224) some [calcium ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098703) -- [definition](http://purl.obolibrary.org/obo/IAO_0000115) [IAO_0000117](http://purl.obolibrary.org/obo/IAO_0000117) "PERSON:Daniel Schober"@en +### calcium-mediated signaling using intracellular calcium source `http://purl.obolibrary.org/obo/GO_0035584` -### dendritic cell, human `http://purl.obolibrary.org/obo/CL_0001056` -#### Removed -- [dendritic cell, human](http://purl.obolibrary.org/obo/CL_0001056) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +#### Added +- [calcium-mediated signaling using intracellular calcium source](http://purl.obolibrary.org/obo/GO_0035584) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "calcium signaling using intracellular calcium source" +- [calcium-mediated signaling using intracellular calcium source](http://purl.obolibrary.org/obo/GO_0035584) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "calcium signalling using intracellular calcium source" +- [calcium-mediated signaling using intracellular calcium source](http://purl.obolibrary.org/obo/GO_0035584) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2010-10-18T11:01:08Z" -### denotator type `http://purl.obolibrary.org/obo/IAO_0000409` +- [calcium-mediated signaling using intracellular calcium source](http://purl.obolibrary.org/obo/GO_0035584) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "calcium-mediated signalling using intracellular calcium source" -#### Added -- [denotator type](http://purl.obolibrary.org/obo/IAO_0000409) [IAO_0000112](http://purl.obolibrary.org/obo/IAO_0000112) "The Basic Formal Ontology ontology makes a distinction between Universals and defined classes, where the formal are "natural kinds" and the latter arbitrary collections of entities."@en +- [calcium-mediated signaling using intracellular calcium source](http://purl.obolibrary.org/obo/GO_0035584) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0035584" -- [denotator type](http://purl.obolibrary.org/obo/IAO_0000409) [IAO_0000119](http://purl.obolibrary.org/obo/IAO_0000119) "Barry Smith, Werner Ceusters"@en +- [calcium-mediated signaling using intracellular calcium source](http://purl.obolibrary.org/obo/GO_0035584) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" -- [denotator type](http://purl.obolibrary.org/obo/IAO_0000409) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "denotator type"@en +- [calcium-mediated signaling using intracellular calcium source](http://purl.obolibrary.org/obo/GO_0035584) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The series of molecular signals in which a cell uses calcium ions released from an intracellular store to convert a signal into a response." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:bf" -- [denotator type](http://purl.obolibrary.org/obo/IAO_0000409) [label](http://www.w3.org/2000/01/rdf-schema#label) "denotator type"@en + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:20192754" -- [denotator type](http://purl.obolibrary.org/obo/IAO_0000409) [IAO_0000117](http://purl.obolibrary.org/obo/IAO_0000117) "Alan Ruttenberg"@en + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:BHF" -- [denotator type](http://purl.obolibrary.org/obo/IAO_0000409) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A denotator type indicates how a term should be interpreted from an ontological perspective."@en +- [calcium-mediated signaling using intracellular calcium source](http://purl.obolibrary.org/obo/GO_0035584) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "bf" -- Class: [denotator type](http://purl.obolibrary.org/obo/IAO_0000409) +- [calcium-mediated signaling using intracellular calcium source](http://purl.obolibrary.org/obo/GO_0035584) [label](http://www.w3.org/2000/01/rdf-schema#label) "calcium-mediated signaling using intracellular calcium source" -- [denotator type](http://purl.obolibrary.org/obo/IAO_0000409) EquivalentTo {[universal](http://purl.obolibrary.org/obo/IAO_0000410) , [defined class](http://purl.obolibrary.org/obo/IAO_0000420) , [named class expression](http://purl.obolibrary.org/obo/IAO_0000421)} +- Class: [calcium-mediated signaling using intracellular calcium source](http://purl.obolibrary.org/obo/GO_0035584) -- [denotator type](http://purl.obolibrary.org/obo/IAO_0000409) SubClassOf [data about an ontology part](http://purl.obolibrary.org/obo/IAO_0000102) +- [calcium-mediated signaling using intracellular calcium source](http://purl.obolibrary.org/obo/GO_0035584) EquivalentTo [calcium-mediated signaling](http://purl.obolibrary.org/obo/GO_0019722) and ([starts with](http://purl.obolibrary.org/obo/RO_0002224) some [release of sequestered calcium ion into cytosol](http://purl.obolibrary.org/obo/GO_0051209)) +- [calcium-mediated signaling using intracellular calcium source](http://purl.obolibrary.org/obo/GO_0035584) SubClassOf [calcium-mediated signaling](http://purl.obolibrary.org/obo/GO_0019722) -### dense mesenchyme tissue `http://purl.obolibrary.org/obo/UBERON_0007524` -#### Removed -- [dense mesenchyme tissue](http://purl.obolibrary.org/obo/UBERON_0007524) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [calcium-mediated signaling using intracellular calcium source](http://purl.obolibrary.org/obo/GO_0035584) SubClassOf [starts with](http://purl.obolibrary.org/obo/RO_0002224) some [release of sequestered calcium ion into cytosol](http://purl.obolibrary.org/obo/GO_0051209) +### calcium-release channel activity `http://purl.obolibrary.org/obo/GO_0015278` -### dental epithelium `http://purl.obolibrary.org/obo/UBERON_0003843` -#### Removed -- [dental epithelium](http://purl.obolibrary.org/obo/UBERON_0003843) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +#### Added +- [calcium-release channel activity](http://purl.obolibrary.org/obo/GO_0015278) [has_alternative_id](http://www.geneontology.org/formats/oboInOwl#hasAlternativeId) "GO:0005218" +- [calcium-release channel activity](http://purl.obolibrary.org/obo/GO_0015278) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-9717215" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "ITPR3 transports Ca2+ from the endoplasmic reticulum to the cytosol" +- [calcium-release channel activity](http://purl.obolibrary.org/obo/GO_0015278) [label](http://www.w3.org/2000/01/rdf-schema#label) "calcium-release channel activity" -### dental papilla cell `http://purl.obolibrary.org/obo/CL_0000345` -#### Removed -- [dental papilla cell](http://purl.obolibrary.org/obo/CL_0000345) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [calcium-release channel activity](http://purl.obolibrary.org/obo/GO_0015278) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "intracellular ligand-gated calcium channel activity" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GO:0015278" +- [calcium-release channel activity](http://purl.obolibrary.org/obo/GO_0015278) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Enables the transmembrane transfer of a calcium ion from intracellular stores by a channel that opens when a specific intracellular ligand has been bound by the channel complex or one of its constituent parts." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:mah" +- [calcium-release channel activity](http://purl.obolibrary.org/obo/GO_0015278) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0015278" -### dental pulp `http://purl.obolibrary.org/obo/UBERON_0001754` -#### Removed -- [dental pulp](http://purl.obolibrary.org/obo/UBERON_0001754) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [calcium-release channel activity](http://purl.obolibrary.org/obo/GO_0015278) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "molecular_function" +- Class: [calcium-release channel activity](http://purl.obolibrary.org/obo/GO_0015278) +- [calcium-release channel activity](http://purl.obolibrary.org/obo/GO_0015278) EquivalentTo [ligand-gated channel activity](http://purl.obolibrary.org/obo/GO_0022834) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [release of sequestered calcium ion into cytosol](http://purl.obolibrary.org/obo/GO_0051209)) and ([has primary input](http://purl.obolibrary.org/obo/RO_0004009) some [CHEBI_29108](http://purl.obolibrary.org/obo/CHEBI_29108)) -### dentate gyrus granule cell layer `http://purl.obolibrary.org/obo/UBERON_0005381` -#### Removed -- [dentate gyrus granule cell layer](http://purl.obolibrary.org/obo/UBERON_0005381) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [calcium-release channel activity](http://purl.obolibrary.org/obo/GO_0015278) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [release of sequestered calcium ion into cytosol](http://purl.obolibrary.org/obo/GO_0051209) +- [calcium-release channel activity](http://purl.obolibrary.org/obo/GO_0015278) SubClassOf [intracellular ligand-gated monoatomic ion channel activity](http://purl.obolibrary.org/obo/GO_0005217) +- [calcium-release channel activity](http://purl.obolibrary.org/obo/GO_0015278) SubClassOf [ligand-gated calcium channel activity](http://purl.obolibrary.org/obo/GO_0099604) -### dentate gyrus of hippocampal formation granule cell `http://purl.obolibrary.org/obo/CL_2000089` -#### Removed -- [dentate gyrus of hippocampal formation granule cell](http://purl.obolibrary.org/obo/CL_2000089) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "The granule cell has a characteristic cone-shaped tree of spiny apical dendrites." -- [dentate gyrus of hippocampal formation granule cell](http://purl.obolibrary.org/obo/CL_2000089) [label](http://www.w3.org/2000/01/rdf-schema#label) "dentate gyrus of hippocampal formation granule cell" +### carbohydrate import across plasma membrane `http://purl.obolibrary.org/obo/GO_0098704` -- [dentate gyrus of hippocampal formation granule cell](http://purl.obolibrary.org/obo/CL_2000089) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The principal cell type of the dentate gyrus." - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" +#### Added +- [carbohydrate import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098704) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0098704" -- [dentate gyrus of hippocampal formation granule cell](http://purl.obolibrary.org/obo/CL_2000089) EquivalentTo [granule cell](http://purl.obolibrary.org/obo/CL_0000120) and ([has soma location](http://purl.obolibrary.org/obo/RO_0002100) some [dentate gyrus of hippocampal formation](http://purl.obolibrary.org/obo/UBERON_0001885)) +- [carbohydrate import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098704) [label](http://www.w3.org/2000/01/rdf-schema#label) "carbohydrate import across plasma membrane" -#### Added -- [dentate gyrus of hippocampal formation granule cell](http://purl.obolibrary.org/obo/CL_2000089) [label](http://www.w3.org/2000/01/rdf-schema#label) "dentate gyrus granule cell" +- [carbohydrate import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098704) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The directed movement of a carbohydrate from outside of a cell, across the plasma membrane and into the cytosol." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dos" -- [dentate gyrus of hippocampal formation granule cell](http://purl.obolibrary.org/obo/CL_2000089) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "dentate gyrus of hippocampal formation granule cell" +- [carbohydrate import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098704) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "pr" -- [dentate gyrus of hippocampal formation granule cell](http://purl.obolibrary.org/obo/CL_2000089) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A granule cell that has soma location in the dentate gyrus cell layer of the hippocampal formation and has an elliptical cell body and characteristic cone-shaped tree of spiny apical dendrites. The branches extend throughout the molecular layer and the distal tips of the dendritic tree end just at the hippocampal fissure or at the ventricular surface. The dentate gyrus granule cell is the principal cell type of the dentate gyrus." - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:17765709" - - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" - -- [dentate gyrus of hippocampal formation granule cell](http://purl.obolibrary.org/obo/CL_2000089) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "As far as can be determined, all dentate granule cells appear to project to CA3 and the axon trajectory is partially correlated with the position of the parent cell body." - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:17765709" - -- [dentate gyrus of hippocampal formation granule cell](http://purl.obolibrary.org/obo/CL_2000089) EquivalentTo [hippocampal granule cell](http://purl.obolibrary.org/obo/CL_0001033) and ([has soma location](http://purl.obolibrary.org/obo/RO_0002100) some [dentate gyrus granule cell layer](http://purl.obolibrary.org/obo/UBERON_0005381)) +- [carbohydrate import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098704) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "carbohydrate import into cell" -- [dentate gyrus of hippocampal formation granule cell](http://purl.obolibrary.org/obo/CL_2000089) SubClassOf [has soma location](http://purl.obolibrary.org/obo/RO_0002100) some [dentate gyrus granule cell layer](http://purl.obolibrary.org/obo/UBERON_0005381) +- [carbohydrate import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098704) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2012-05-31T02:45:02Z" +- [carbohydrate import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098704) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" -### dentition `http://purl.obolibrary.org/obo/UBERON_0003672` -#### Removed -- [dentition](http://purl.obolibrary.org/obo/UBERON_0003672) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [carbohydrate import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098704) [has_alternative_id](http://www.geneontology.org/formats/oboInOwl#hasAlternativeId) "GO:0097319" +- Class: [carbohydrate import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098704) +- [carbohydrate import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098704) EquivalentTo [transport](http://purl.obolibrary.org/obo/GO_0006810) and ([has target start location](http://purl.obolibrary.org/obo/RO_0002338) some [extracellular region](http://purl.obolibrary.org/obo/GO_0005576)) and ([has target end location](http://purl.obolibrary.org/obo/RO_0002339) some [cytosol](http://purl.obolibrary.org/obo/GO_0005829)) and ([results in transport across](http://purl.obolibrary.org/obo/RO_0002342) some [plasma membrane](http://purl.obolibrary.org/obo/GO_0005886)) and ([has primary input](http://purl.obolibrary.org/obo/RO_0004009) some [CHEBI_16646](http://purl.obolibrary.org/obo/CHEBI_16646)) -### dermal papilla `http://purl.obolibrary.org/obo/UBERON_0000412` -#### Removed -- [dermal papilla](http://purl.obolibrary.org/obo/UBERON_0000412) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [carbohydrate import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098704) SubClassOf [carbohydrate transmembrane transport](http://purl.obolibrary.org/obo/GO_0034219) +- [carbohydrate import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098704) SubClassOf [import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098739) -### dermatome `http://purl.obolibrary.org/obo/UBERON_0004016` +### cardioblast `http://purl.obolibrary.org/obo/CL_0002664` #### Removed -- [dermatome](http://purl.obolibrary.org/obo/UBERON_0004016) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) - +- [cardioblast](http://purl.obolibrary.org/obo/CL_0002664) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "CPC" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:19745164" +#### Added +- [cardioblast](http://purl.obolibrary.org/obo/CL_0002664) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "CPC" + - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation) -### dermomyotome `http://purl.obolibrary.org/obo/UBERON_0004290` -#### Removed -- [dermomyotome](http://purl.obolibrary.org/obo/UBERON_0004290) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:19745164" +### cartilage of bronchus `http://purl.obolibrary.org/obo/UBERON_0001956` -### descending colon `http://purl.obolibrary.org/obo/UBERON_0001158` -#### Removed -- [descending colon](http://purl.obolibrary.org/obo/UBERON_0001158) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +#### Added +- [cartilage of bronchus](http://purl.obolibrary.org/obo/UBERON_0001956) [contributor](http://purl.org/dc/terms/contributor) [0000-0001-6677-8489](https://orcid.org/0000-0001-6677-8489) +- [cartilage of bronchus](http://purl.obolibrary.org/obo/UBERON_0001956) SubClassOf [has part](http://purl.obolibrary.org/obo/BFO_0000051) some [tracheobronchial chondrocyte](http://purl.obolibrary.org/obo/CL_0019002) -### developmentally induced by `http://purl.obolibrary.org/obo/RO_0002256` +### cell death `http://purl.obolibrary.org/obo/GO_0008219` #### Removed -- [developmentally induced by](http://purl.obolibrary.org/obo/RO_0002256) Domain [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) - -- [developmentally induced by](http://purl.obolibrary.org/obo/RO_0002256) Range [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [cell death](http://purl.obolibrary.org/obo/GO_0008219) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "This term should not be used for direct annotation. The only exception should be when experimental data (e.g., staining with trypan blue or propidium iodide) show that cell death has occurred, but fail to provide details on death modality (accidental versus programmed). When information is provided on the cell death mechanism, annotations should be made to the appropriate descendant of 'cell death' (such as, but not limited to, GO:0097300 'programmed necrotic cell death' or GO:0006915 'apoptotic process'). Also, if experimental data suggest that a gene product influences cell death indirectly, rather than being involved in the death process directly, consider annotating to a 'regulation' term." #### Added -- [developmentally induced by](http://purl.obolibrary.org/obo/RO_0002256) Domain [material anatomical entity](http://purl.obolibrary.org/obo/UBERON_0000465) - -- [developmentally induced by](http://purl.obolibrary.org/obo/RO_0002256) Range [material anatomical entity](http://purl.obolibrary.org/obo/UBERON_0000465) +- [cell death](http://purl.obolibrary.org/obo/GO_0008219) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate) +- [cell death](http://purl.obolibrary.org/obo/GO_0008219) [term tracker item](http://purl.obolibrary.org/obo/IAO_0000233) "https://github.com/geneontology/go-ontology/issues/24680"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI) -### develops in `http://purl.obolibrary.org/obo/RO_0002226` -#### Removed -- [develops in](http://purl.obolibrary.org/obo/RO_0002226) Domain [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) - -#### Added -- [develops in](http://purl.obolibrary.org/obo/RO_0002226) Domain [anatomical entity](http://purl.obolibrary.org/obo/UBERON_0001062) +- [cell death](http://purl.obolibrary.org/obo/GO_0008219) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "This term should not be used for direct annotation, it is currently kept in GO as a placeholder for describing cell death phenotypes in uPHENO. When information is provided on a programmed cell death mechanism, annotations should be made to the appropriate descendant of 'cell death' (such as, but not limited to, GO:0097300 'programmed necrotic cell death' or GO:0006915 'apoptotic process'). Unintentional cell death, i.e. cell death caused by injury, ageing, or cell phenotypes observed as a result of a pathological mutation in an essential gene should NOT be annotated using GO terms." -### differentiated genital tubercle `http://purl.obolibrary.org/obo/UBERON_0011757` +### cell maturation `http://purl.obolibrary.org/obo/GO_0048469` #### Removed -- [differentiated genital tubercle](http://purl.obolibrary.org/obo/UBERON_0011757) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [cell maturation](http://purl.obolibrary.org/obo/GO_0048469) SubClassOf [developmental maturation](http://purl.obolibrary.org/obo/GO_0021700) +#### Added +- [cell maturation](http://purl.obolibrary.org/obo/GO_0048469) SubClassOf [anatomical structure maturation](http://purl.obolibrary.org/obo/GO_0071695) -### digestive tract `http://purl.obolibrary.org/obo/UBERON_0001555` +### cell morphogenesis involved in Malpighian tubule morphogenesis `http://purl.obolibrary.org/obo/GO_0061336` #### Removed -- [digestive tract](http://purl.obolibrary.org/obo/UBERON_0001555) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [cell morphogenesis involved in Malpighian tubule morphogenesis](http://purl.obolibrary.org/obo/GO_0061336) EquivalentTo [cell morphogenesis involved in differentiation](http://purl.obolibrary.org/obo/GO_0000904) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [Malpighian tubule morphogenesis](http://purl.obolibrary.org/obo/GO_0007443)) +- [cell morphogenesis involved in Malpighian tubule morphogenesis](http://purl.obolibrary.org/obo/GO_0061336) SubClassOf [cell morphogenesis involved in differentiation](http://purl.obolibrary.org/obo/GO_0000904) +#### Added +- [cell morphogenesis involved in Malpighian tubule morphogenesis](http://purl.obolibrary.org/obo/GO_0061336) EquivalentTo [cell morphogenesis](http://purl.obolibrary.org/obo/GO_0000902) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [Malpighian tubule morphogenesis](http://purl.obolibrary.org/obo/GO_0007443)) -### digit plus metapodial segment `http://purl.obolibrary.org/obo/UBERON_5002544` -#### Removed -- [digit plus metapodial segment](http://purl.obolibrary.org/obo/UBERON_5002544) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000) - +- [cell morphogenesis involved in Malpighian tubule morphogenesis](http://purl.obolibrary.org/obo/GO_0061336) SubClassOf [cell morphogenesis](http://purl.obolibrary.org/obo/GO_0000902) -### digitopodium region `http://purl.obolibrary.org/obo/UBERON_0012140` +### cell morphogenesis involved in differentiation `http://purl.obolibrary.org/obo/GO_0000904` #### Removed -- [digitopodium region](http://purl.obolibrary.org/obo/UBERON_0012140) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000) - +- [cell morphogenesis involved in differentiation](http://purl.obolibrary.org/obo/GO_0000904) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" +- [cell morphogenesis involved in differentiation](http://purl.obolibrary.org/obo/GO_0000904) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The change in form (cell shape and size) that occurs when relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:go_curators" -### dilatator pupillae `http://purl.obolibrary.org/obo/UBERON_0001608` -#### Removed -- [dilatator pupillae](http://purl.obolibrary.org/obo/UBERON_0001608) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000) +- [cell morphogenesis involved in differentiation](http://purl.obolibrary.org/obo/GO_0000904) [label](http://www.w3.org/2000/01/rdf-schema#label) "cell morphogenesis involved in differentiation" +- [cell morphogenesis involved in differentiation](http://purl.obolibrary.org/obo/GO_0000904) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0000904" +- Class: [cell morphogenesis involved in differentiation](http://purl.obolibrary.org/obo/GO_0000904) -### directly develops from `http://purl.obolibrary.org/obo/RO_0002207` -#### Removed -- [directly develops from](http://purl.obolibrary.org/obo/RO_0002207) Domain [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000) or [cell](http://purl.obolibrary.org/obo/CL_0000000) +- [cell morphogenesis involved in differentiation](http://purl.obolibrary.org/obo/GO_0000904) EquivalentTo [cell morphogenesis](http://purl.obolibrary.org/obo/GO_0000902) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [cell development](http://purl.obolibrary.org/obo/GO_0048468)) -- [directly develops from](http://purl.obolibrary.org/obo/RO_0002207) Range [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000) or [cell](http://purl.obolibrary.org/obo/CL_0000000) +- [cell morphogenesis involved in differentiation](http://purl.obolibrary.org/obo/GO_0000904) SubClassOf [cell morphogenesis](http://purl.obolibrary.org/obo/GO_0000902) -#### Added -- [directly develops from](http://purl.obolibrary.org/obo/RO_0002207) Domain [cell](http://purl.obolibrary.org/obo/CL_0000000) or [multicellular anatomical structure](http://purl.obolibrary.org/obo/UBERON_0010000) +- [cell morphogenesis involved in differentiation](http://purl.obolibrary.org/obo/GO_0000904) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [cell development](http://purl.obolibrary.org/obo/GO_0048468) -- [directly develops from](http://purl.obolibrary.org/obo/RO_0002207) Range [cell](http://purl.obolibrary.org/obo/CL_0000000) or [multicellular anatomical structure](http://purl.obolibrary.org/obo/UBERON_0010000) -### directly negatively regulated by `http://purl.obolibrary.org/obo/RO_0002023` +### cell morphogenesis involved in neuron differentiation `http://purl.obolibrary.org/obo/GO_0048667` #### Removed -- [directly negatively regulated by](http://purl.obolibrary.org/obo/RO_0002023) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "dos" - -- [directly negatively regulated by](http://purl.obolibrary.org/obo/RO_0002023) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Process(P2) is directly negatively regulated by process(P1) iff: P1 negatively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding negatively regulates the kinase activity (P2) of protein B then P2 directly negatively regulated by P1." - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dos" +- [cell morphogenesis involved in neuron differentiation](http://purl.obolibrary.org/obo/GO_0048667) SubClassOf [cell morphogenesis involved in differentiation](http://purl.obolibrary.org/obo/GO_0000904) #### Added -- [directly negatively regulated by](http://purl.obolibrary.org/obo/RO_0002023) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) [0000-0002-7073-9172](https://orcid.org/0000-0002-7073-9172) - -- [directly negatively regulated by](http://purl.obolibrary.org/obo/RO_0002023) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Process(P2) is directly negatively regulated by process(P1) iff: P1 negatively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding negatively regulates the kinase activity (P2) of protein B then P2 directly negatively regulated by P1." - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) [0000-0002-7073-9172](https://orcid.org/0000-0002-7073-9172) +- [cell morphogenesis involved in neuron differentiation](http://purl.obolibrary.org/obo/GO_0048667) SubClassOf [cell morphogenesis](http://purl.obolibrary.org/obo/GO_0000902) -### directly negatively regulates `http://purl.obolibrary.org/obo/RO_0002630` +### cell projection organization `http://purl.obolibrary.org/obo/GO_0030030` #### Added -- [directly negatively regulates](http://purl.obolibrary.org/obo/RO_0002630) [see also](http://www.w3.org/2000/01/rdf-schema#seeAlso) "https://wiki.geneontology.org/Directly_negatively_regulates"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI) +- [cell projection organization](http://purl.obolibrary.org/obo/GO_0030030) SubClassOf [cell population proliferation](http://purl.obolibrary.org/obo/GO_0008283) -### directly positively regulated by `http://purl.obolibrary.org/obo/RO_0002024` +### cell surface receptor signaling pathway involved in cell-cell signaling `http://purl.obolibrary.org/obo/GO_1905114` #### Removed -- [directly positively regulated by](http://purl.obolibrary.org/obo/RO_0002024) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "dos" - -- [directly positively regulated by](http://purl.obolibrary.org/obo/RO_0002024) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Process(P2) is directly postively regulated by process(P1) iff: P1 positively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding positively regulates the kinase activity (P2) of protein B then P2 is directly postively regulated by P1." - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dos" +- [cell surface receptor signaling pathway involved in cell-cell signaling](http://purl.obolibrary.org/obo/GO_1905114) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" -#### Added -- [directly positively regulated by](http://purl.obolibrary.org/obo/RO_0002024) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) [0000-0002-7073-9172](https://orcid.org/0000-0002-7073-9172) +- [cell surface receptor signaling pathway involved in cell-cell signaling](http://purl.obolibrary.org/obo/GO_1905114) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "cell surface receptor linked signal transduction involved in cell-cell signalling" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" -- [directly positively regulated by](http://purl.obolibrary.org/obo/RO_0002024) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Process(P2) is directly postively regulated by process(P1) iff: P1 positively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding positively regulates the kinase activity (P2) of protein B then P2 is directly postively regulated by P1." - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) [0000-0002-7073-9172](https://orcid.org/0000-0002-7073-9172) +- [cell surface receptor signaling pathway involved in cell-cell signaling](http://purl.obolibrary.org/obo/GO_1905114) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any cell surface receptor signaling pathway that is involved in cell-cell signaling." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GO_REF:0000060" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" -### directly positively regulates `http://purl.obolibrary.org/obo/RO_0002629` + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ISBN:0-7167-3051-0" -#### Added -- [directly positively regulates](http://purl.obolibrary.org/obo/RO_0002629) [see also](http://www.w3.org/2000/01/rdf-schema#seeAlso) "https://wiki.geneontology.org/Directly_positively_regulates"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI) +- [cell surface receptor signaling pathway involved in cell-cell signaling](http://purl.obolibrary.org/obo/GO_1905114) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "cell surface receptor linked signaling pathway involved in cell-cell signalling" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" +- [cell surface receptor signaling pathway involved in cell-cell signaling](http://purl.obolibrary.org/obo/GO_1905114) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "cell surface receptor linked signal transduction involved in cell-cell signaling" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" -### directly regulated by `http://purl.obolibrary.org/obo/RO_0002022` -#### Removed -- [directly regulated by](http://purl.obolibrary.org/obo/RO_0002022) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "dos" +- [cell surface receptor signaling pathway involved in cell-cell signaling](http://purl.obolibrary.org/obo/GO_1905114) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "cell surface receptor linked signalling pathway involved in cell-cell signaling" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" -- [directly regulated by](http://purl.obolibrary.org/obo/RO_0002022) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "Process(P2) is directly regulated by process(P1) iff: P1 regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding regulates the kinase activity (P2) of protein B then P1 directly regulates P2." - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dos" +- [cell surface receptor signaling pathway involved in cell-cell signaling](http://purl.obolibrary.org/obo/GO_1905114) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "cell surface receptor linked signalling pathway involved in cell-cell signalling" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" -#### Added -- [directly regulated by](http://purl.obolibrary.org/obo/RO_0002022) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "Process(P2) is directly regulated by process(P1) iff: P1 regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding regulates the kinase activity (P2) of protein B then P1 directly regulates P2." - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) [0000-0002-7073-9172](https://orcid.org/0000-0002-7073-9172) +- [cell surface receptor signaling pathway involved in cell-cell signaling](http://purl.obolibrary.org/obo/GO_1905114) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "dos" -- [directly regulated by](http://purl.obolibrary.org/obo/RO_0002022) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) [0000-0002-7073-9172](https://orcid.org/0000-0002-7073-9172) +- [cell surface receptor signaling pathway involved in cell-cell signaling](http://purl.obolibrary.org/obo/GO_1905114) [label](http://www.w3.org/2000/01/rdf-schema#label) "cell surface receptor signaling pathway involved in cell-cell signaling" +- [cell surface receptor signaling pathway involved in cell-cell signaling](http://purl.obolibrary.org/obo/GO_1905114) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:1905114" -### ductal plate `http://purl.obolibrary.org/obo/UBERON_8410003` -#### Removed -- [ductal plate](http://purl.obolibrary.org/obo/UBERON_8410003) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [cell surface receptor signaling pathway involved in cell-cell signaling](http://purl.obolibrary.org/obo/GO_1905114) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "cell surface receptor signaling pathway involved in cell-cell signalling" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" +- [cell surface receptor signaling pathway involved in cell-cell signaling](http://purl.obolibrary.org/obo/GO_1905114) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "cell surface receptor linked signaling pathway involved in cell-cell signaling" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" +- [cell surface receptor signaling pathway involved in cell-cell signaling](http://purl.obolibrary.org/obo/GO_1905114) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2016-04-06T16:59:57Z" -### ear hair cell `http://purl.obolibrary.org/obo/CL_0002374` -#### Removed -- [ear hair cell](http://purl.obolibrary.org/obo/CL_0002374) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- Class: [cell surface receptor signaling pathway involved in cell-cell signaling](http://purl.obolibrary.org/obo/GO_1905114) +- [cell surface receptor signaling pathway involved in cell-cell signaling](http://purl.obolibrary.org/obo/GO_1905114) EquivalentTo [cell surface receptor signaling pathway](http://purl.obolibrary.org/obo/GO_0007166) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [cell-cell signaling](http://purl.obolibrary.org/obo/GO_0007267)) +- [cell surface receptor signaling pathway involved in cell-cell signaling](http://purl.obolibrary.org/obo/GO_1905114) SubClassOf [cell surface receptor signaling pathway](http://purl.obolibrary.org/obo/GO_0007166) -### early T lineage precursor `http://purl.obolibrary.org/obo/CL_0002425` -#### Removed -- [early T lineage precursor](http://purl.obolibrary.org/obo/CL_0002425) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [cell surface receptor signaling pathway involved in cell-cell signaling](http://purl.obolibrary.org/obo/GO_1905114) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [cell-cell signaling](http://purl.obolibrary.org/obo/GO_0007267) -### early pro-B cell `http://purl.obolibrary.org/obo/CL_0002046` -#### Removed -- [early pro-B cell](http://purl.obolibrary.org/obo/CL_0002046) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +### cellular anatomical entity `http://purl.obolibrary.org/obo/GO_0110165` +#### Added +- [cellular anatomical entity](http://purl.obolibrary.org/obo/GO_0110165) SubClassOf [anatomical structure](http://purl.obolibrary.org/obo/UBERON_0000061) -### early telencephalic vesicle `http://purl.obolibrary.org/obo/UBERON_0009676` -#### Removed -- [early telencephalic vesicle](http://purl.obolibrary.org/obo/UBERON_0009676) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +### cellular lipid catabolic process `http://purl.obolibrary.org/obo/GO_0044242` +#### Added +- [cellular lipid catabolic process](http://purl.obolibrary.org/obo/GO_0044242) [label](http://www.w3.org/2000/01/rdf-schema#label) "cellular lipid catabolic process" +- [cellular lipid catabolic process](http://purl.obolibrary.org/obo/GO_0044242) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The chemical reactions and pathways resulting in the breakdown of lipids, as carried out by individual cells." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:jl" -### eccentric medium spiny neuron `http://purl.obolibrary.org/obo/CL_4030057` +- [cellular lipid catabolic process](http://purl.obolibrary.org/obo/GO_0044242) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "cellular lipid degradation" -#### Added -- [eccentric medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030057) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "eccentric MSN" - - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation) +- [cellular lipid catabolic process](http://purl.obolibrary.org/obo/GO_0044242) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "cellular lipid catabolism" - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1101/2022.10.12.511898" +- [cellular lipid catabolic process](http://purl.obolibrary.org/obo/GO_0044242) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0044242" -- [eccentric medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030057) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "The term “eccentric” is used in the name eccentric medium spiny neuron (MSN) due to the exhibited transcriptional divergence from canonical spiny projection neurons. It has been noted in at least one study that an eccentric MSN differs in expression from direct and indirect MSNs by 110 genes (more than the 68 that distinguished direct and indirect spiny projection neurons from each other) and expresses many genes that have little expression in the rest of the striatum. It also has been noted in at least one human study that most eccentric MSNs expressed only DRD1, but many in the basal ganglia co-expressed DRD1 and DRD2, suggesting regional specialization of a more broadly distributed cell type." - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/j.cell.2018.07.028" +- [cellular lipid catabolic process](http://purl.obolibrary.org/obo/GO_0044242) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "cellular lipid breakdown" - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1101/2022.10.12.511898" +- [cellular lipid catabolic process](http://purl.obolibrary.org/obo/GO_0044242) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" -- [eccentric medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030057) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "eccentric SPN" - - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation) +- Class: [cellular lipid catabolic process](http://purl.obolibrary.org/obo/GO_0044242) - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/j.cell.2018.07.028" +- [cellular lipid catabolic process](http://purl.obolibrary.org/obo/GO_0044242) SubClassOf [cellular catabolic process](http://purl.obolibrary.org/obo/GO_0044248) -- [eccentric medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030057) [date](http://purl.org/dc/terms/date) "2023-06-23T14:59:36Z"^^[dateTime](http://www.w3.org/2001/XMLSchema#dateTime) +- [cellular lipid catabolic process](http://purl.obolibrary.org/obo/GO_0044242) SubClassOf [cellular lipid metabolic process](http://purl.obolibrary.org/obo/GO_0044255) -- [eccentric medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030057) [label](http://www.w3.org/2000/01/rdf-schema#label) "eccentric medium spiny neuron" +- [cellular lipid catabolic process](http://purl.obolibrary.org/obo/GO_0044242) SubClassOf [lipid catabolic process](http://purl.obolibrary.org/obo/GO_0016042) -- [eccentric medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030057) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A medium spiny neuron that exhibits transcriptional divergence from direct and indirect spiny projection neurons, for example, enrichment in Casz1, Otof, Cacng5 and Pcdh8 noted in mice. Whilst in general medium spiny neurons have been found to be differentially distributed across the basal ganglia, the eccentric medium spiny neuron cell type has been found to be more evenly distributed throughout cerebral nuclei." - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/j.cell.2018.07.028" - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1101/2022.10.12.511898" +### cellular lipid metabolic process `http://purl.obolibrary.org/obo/GO_0044255` -- [eccentric medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030057) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "eSPN" - - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation) +#### Added +- [cellular lipid metabolic process](http://purl.obolibrary.org/obo/GO_0044255) [label](http://www.w3.org/2000/01/rdf-schema#label) "cellular lipid metabolic process" - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/j.cell.2018.07.028" +- [cellular lipid metabolic process](http://purl.obolibrary.org/obo/GO_0044255) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The chemical reactions and pathways involving lipids, as carried out by individual cells." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:jl" -- [eccentric medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030057) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "eccentric spiny projection neuron" - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/j.cell.2018.07.028" +- [cellular lipid metabolic process](http://purl.obolibrary.org/obo/GO_0044255) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0044255" -- Class: [eccentric medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030057) +- [cellular lipid metabolic process](http://purl.obolibrary.org/obo/GO_0044255) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "cellular lipid metabolism" -- [eccentric medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030057) SubClassOf [medium spiny neuron](http://purl.obolibrary.org/obo/CL_1001474) +- [cellular lipid metabolic process](http://purl.obolibrary.org/obo/GO_0044255) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" +- [cellular lipid metabolic process](http://purl.obolibrary.org/obo/GO_0044255) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [goslim_pir](http://purl.obolibrary.org/obo/go#goslim_pir) -### ecto-epithelial cell `http://purl.obolibrary.org/obo/CL_0002077` -#### Removed -- [ecto-epithelial cell](http://purl.obolibrary.org/obo/CL_0002077) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- Class: [cellular lipid metabolic process](http://purl.obolibrary.org/obo/GO_0044255) +- [cellular lipid metabolic process](http://purl.obolibrary.org/obo/GO_0044255) SubClassOf [lipid metabolic process](http://purl.obolibrary.org/obo/GO_0006629) +- [cellular lipid metabolic process](http://purl.obolibrary.org/obo/GO_0044255) SubClassOf [cellular metabolic process](http://purl.obolibrary.org/obo/GO_0044237) -### ectoderm-derived structure `http://purl.obolibrary.org/obo/UBERON_0004121` -#### Removed -- [ectoderm-derived structure](http://purl.obolibrary.org/obo/UBERON_0004121) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +### cellular response to calcium ion `http://purl.obolibrary.org/obo/GO_0071277` +#### Added +- [cellular response to calcium ion](http://purl.obolibrary.org/obo/GO_0071277) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" -### ectonucleotide pyrophosphatase/phosphodiesterase family member 3 `http://purl.obolibrary.org/obo/PR_000001344` +- [cellular response to calcium ion](http://purl.obolibrary.org/obo/GO_0071277) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0071277" -#### Added -- [ectonucleotide pyrophosphatase/phosphodiesterase family member 3](http://purl.obolibrary.org/obo/PR_000001344) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [ectonucleotide pyrophosphatase/phosphodiesterase family member 3 (human)](http://purl.obolibrary.org/obo/PR_O14638) +- [cellular response to calcium ion](http://purl.obolibrary.org/obo/GO_0071277) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:mah" +- [cellular response to calcium ion](http://purl.obolibrary.org/obo/GO_0071277) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "cellular response to Ca2+ ion" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:mah" -### editor note `http://purl.obolibrary.org/obo/IAO_0000116` +- [cellular response to calcium ion](http://purl.obolibrary.org/obo/GO_0071277) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2009-12-10T03:55:01Z" -#### Added -- [editor note](http://purl.obolibrary.org/obo/IAO_0000116) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "editor note"@en +- [cellular response to calcium ion](http://purl.obolibrary.org/obo/GO_0071277) [label](http://www.w3.org/2000/01/rdf-schema#label) "cellular response to calcium ion" -- [editor note](http://purl.obolibrary.org/obo/IAO_0000116) [IAO_0000117](http://purl.obolibrary.org/obo/IAO_0000117) "PERSON:Daniel Schober"@en +- [cellular response to calcium ion](http://purl.obolibrary.org/obo/GO_0071277) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "mah" -- [editor note](http://purl.obolibrary.org/obo/IAO_0000116) [IAO_0000119](http://purl.obolibrary.org/obo/IAO_0000119) "GROUP:OBI:<http://purl.obofoundry.org/obo/obi>"@en +- Class: [cellular response to calcium ion](http://purl.obolibrary.org/obo/GO_0071277) -- [editor note](http://purl.obolibrary.org/obo/IAO_0000116) [label](http://www.w3.org/2000/01/rdf-schema#label) "editor note"@en +- [cellular response to calcium ion](http://purl.obolibrary.org/obo/GO_0071277) EquivalentTo [cellular response to chemical stimulus](http://purl.obolibrary.org/obo/GO_0070887) and ([has input](http://purl.obolibrary.org/obo/RO_0002233) some [CHEBI_39124](http://purl.obolibrary.org/obo/CHEBI_39124)) -- [editor note](http://purl.obolibrary.org/obo/IAO_0000116) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "An administrative note intended for its editor. It may not be included in the publication version of the ontology, so it should contain nothing necessary for end users to understand the ontology."@en +- [cellular response to calcium ion](http://purl.obolibrary.org/obo/GO_0071277) SubClassOf [cellular response to chemical stimulus](http://purl.obolibrary.org/obo/GO_0070887) -- [editor note](http://purl.obolibrary.org/obo/IAO_0000116) [IAO_0000114](http://purl.obolibrary.org/obo/IAO_0000114) [ready for release](http://purl.obolibrary.org/obo/IAO_0000122) +- [cellular response to calcium ion](http://purl.obolibrary.org/obo/GO_0071277) SubClassOf [has input](http://purl.obolibrary.org/obo/RO_0002233) some [CHEBI_39124](http://purl.obolibrary.org/obo/CHEBI_39124) -- [editor note](http://purl.obolibrary.org/obo/IAO_0000116) [isDefinedBy](http://www.w3.org/2000/01/rdf-schema#isDefinedBy) [iao.owl](http://purl.obolibrary.org/obo/iao.owl) +- [cellular response to calcium ion](http://purl.obolibrary.org/obo/GO_0071277) SubClassOf [response to calcium ion](http://purl.obolibrary.org/obo/GO_0051592) -### egg cell `http://purl.obolibrary.org/obo/CL_0000025` +### chemical synaptic transmission, postsynaptic `http://purl.obolibrary.org/obo/GO_0099565` #### Removed -- [egg cell](http://purl.obolibrary.org/obo/CL_0000025) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) - +- [chemical synaptic transmission, postsynaptic](http://purl.obolibrary.org/obo/GO_0099565) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "postsynaptic process involved in chemical synaptic transmission" + - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [syngo_official_label](http://purl.obolibrary.org/obo/go#syngo_official_label) +- [chemical synaptic transmission, postsynaptic](http://purl.obolibrary.org/obo/GO_0099565) SubClassOf [cell surface receptor signaling pathway involved in cell-cell signaling](http://purl.obolibrary.org/obo/GO_1905114) -### elbow joint `http://purl.obolibrary.org/obo/UBERON_0001490` -#### Removed -- [elbow joint](http://purl.obolibrary.org/obo/UBERON_0001490) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +#### Added +- [chemical synaptic transmission, postsynaptic](http://purl.obolibrary.org/obo/GO_0099565) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "postsynaptic process involved in chemical synaptic transmission" + - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [syngo_official_label](http://purl.obolibrary.org/obo/go#syngo_official_label) +- [chemical synaptic transmission, postsynaptic](http://purl.obolibrary.org/obo/GO_0099565) SubClassOf [cell surface receptor signaling pathway](http://purl.obolibrary.org/obo/GO_0007166) -### elbow joint primordium `http://purl.obolibrary.org/obo/UBERON_0006224` +### chondrocyte morphogenesis `http://purl.obolibrary.org/obo/GO_0090171` #### Removed -- [elbow joint primordium](http://purl.obolibrary.org/obo/UBERON_0006224) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [chondrocyte morphogenesis](http://purl.obolibrary.org/obo/GO_0090171) SubClassOf [cell morphogenesis involved in differentiation](http://purl.obolibrary.org/obo/GO_0000904) +#### Added +- [chondrocyte morphogenesis](http://purl.obolibrary.org/obo/GO_0090171) SubClassOf [cell morphogenesis](http://purl.obolibrary.org/obo/GO_0000902) -### elicited macrophage `http://purl.obolibrary.org/obo/CL_0000861` +### choroid plexus cell `http://purl.obolibrary.org/obo/CL_4023073` #### Removed -- [elicited macrophage](http://purl.obolibrary.org/obo/CL_0000861) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) - +- [choroid plexus cell](http://purl.obolibrary.org/obo/CL_4023073) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A cell that is part of the choroid plexus." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "DOI:10.1101/2022.10.12.511898" +- [choroid plexus cell](http://purl.obolibrary.org/obo/CL_4023073) [label](http://www.w3.org/2000/01/rdf-schema#label) "choroid plexus cell" -### embryonic cloaca `http://purl.obolibrary.org/obo/UBERON_0000163` -#### Removed -- [embryonic cloaca](http://purl.obolibrary.org/obo/UBERON_0000163) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [choroid plexus cell](http://purl.obolibrary.org/obo/CL_4023073) EquivalentTo [native cell](http://purl.obolibrary.org/obo/CL_0000003) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [choroid plexus](http://purl.obolibrary.org/obo/UBERON_0001886)) +- [choroid plexus cell](http://purl.obolibrary.org/obo/CL_4023073) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [choroid plexus](http://purl.obolibrary.org/obo/UBERON_0001886) +- [choroid plexus cell](http://purl.obolibrary.org/obo/CL_4023073) SubClassOf [native cell](http://purl.obolibrary.org/obo/CL_0000003) -### embryonic post-anal tail `http://purl.obolibrary.org/obo/UBERON_0007144` -#### Removed -- [embryonic post-anal tail](http://purl.obolibrary.org/obo/UBERON_0007144) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +#### Added +- [choroid plexus cell](http://purl.obolibrary.org/obo/CL_4023073) [deprecated](http://www.w3.org/2002/07/owl#deprecated) true +- [choroid plexus cell](http://purl.obolibrary.org/obo/CL_4023073) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "https://github.com/obophenotype/cell-ontology/issues/2043" +- [choroid plexus cell](http://purl.obolibrary.org/obo/CL_4023073) [label](http://www.w3.org/2000/01/rdf-schema#label) "obsolete choroid plexus cell" -### embryonic skin basal layer `http://purl.obolibrary.org/obo/UBERON_0011272` -#### Removed -- [embryonic skin basal layer](http://purl.obolibrary.org/obo/UBERON_0011272) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [choroid plexus cell](http://purl.obolibrary.org/obo/CL_4023073) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "OBSOLETE. A cell that is part of the choroid plexus." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "DOI:10.1101/2022.10.12.511898" +- [choroid plexus cell](http://purl.obolibrary.org/obo/CL_4023073) [term replaced by](http://purl.obolibrary.org/obo/IAO_0100001) [choroid plexus epithelial cell](http://purl.obolibrary.org/obo/CL_0000706) -### embryonic urethral groove `http://purl.obolibrary.org/obo/UBERON_0013241` +### choroid plexus epithelial cell `http://purl.obolibrary.org/obo/CL_0000706` #### Removed -- [embryonic urethral groove](http://purl.obolibrary.org/obo/UBERON_0013241) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [choroid plexus epithelial cell](http://purl.obolibrary.org/obo/CL_0000706) SubClassOf [choroid plexus cell](http://purl.obolibrary.org/obo/CL_4023073) +#### Added +- [choroid plexus epithelial cell](http://purl.obolibrary.org/obo/CL_0000706) [date](http://purl.org/dc/terms/date) "2023-08-04T08:48:30Z"^^[dateTime](http://www.w3.org/2001/XMLSchema#dateTime) +- [choroid plexus epithelial cell](http://purl.obolibrary.org/obo/CL_0000706) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "choroid plexus cell" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "DOI:10.1101/2022.10.12.511898" -### enabled by `http://purl.obolibrary.org/obo/RO_0002333` +- [choroid plexus epithelial cell](http://purl.obolibrary.org/obo/CL_0000706) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [choroid plexus](http://purl.obolibrary.org/obo/UBERON_0001886) -#### Added -- [enabled by](http://purl.obolibrary.org/obo/RO_0002333) [see also](http://www.w3.org/2000/01/rdf-schema#seeAlso) "https://wiki.geneontology.org/Enabled_by"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI) +### common lymphoid progenitor `http://purl.obolibrary.org/obo/CL_0000051` +#### Removed +- [common lymphoid progenitor](http://purl.obolibrary.org/obo/CL_0000051) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "ELP" -### enables `http://purl.obolibrary.org/obo/RO_0002327` +- [common lymphoid progenitor](http://purl.obolibrary.org/obo/CL_0000051) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "CLP" #### Added -- [enables](http://purl.obolibrary.org/obo/RO_0002327) [see also](http://www.w3.org/2000/01/rdf-schema#seeAlso) "https://wiki.geneontology.org/Enables"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI) - - -### endo-epithelial cell `http://purl.obolibrary.org/obo/CL_0002076` -#### Removed -- [endo-epithelial cell](http://purl.obolibrary.org/obo/CL_0002076) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [common lymphoid progenitor](http://purl.obolibrary.org/obo/CL_0000051) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "CLP" + - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation) +- [common lymphoid progenitor](http://purl.obolibrary.org/obo/CL_0000051) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "ELP" + - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation) -### endocardium of left ventricle `http://purl.obolibrary.org/obo/UBERON_0009713` +### common myeloid progenitor `http://purl.obolibrary.org/obo/CL_0000049` #### Removed -- [endocardium of left ventricle](http://purl.obolibrary.org/obo/UBERON_0009713) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000) +- [common myeloid progenitor](http://purl.obolibrary.org/obo/CL_0000049) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "CFU-GEMM" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ISBN:0878932437" +- [common myeloid progenitor](http://purl.obolibrary.org/obo/CL_0000049) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "CMP" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ISBN:0878932437" +- [common myeloid progenitor](http://purl.obolibrary.org/obo/CL_0000049) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "CFU-S" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ISBN:0878932437" -### endocardium of right ventricle `http://purl.obolibrary.org/obo/UBERON_0009712` -#### Removed -- [endocardium of right ventricle](http://purl.obolibrary.org/obo/UBERON_0009712) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000) +#### Added +- [common myeloid progenitor](http://purl.obolibrary.org/obo/CL_0000049) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "CFU-S" + - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation) + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ISBN:0878932437" +- [common myeloid progenitor](http://purl.obolibrary.org/obo/CL_0000049) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "CMP" + - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation) -### endoderm-derived structure `http://purl.obolibrary.org/obo/UBERON_0004119` -#### Removed -- [endoderm-derived structure](http://purl.obolibrary.org/obo/UBERON_0004119) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ISBN:0878932437" +- [common myeloid progenitor](http://purl.obolibrary.org/obo/CL_0000049) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "CFU-GEMM" + - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation) + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ISBN:0878932437" -### endoglin `http://purl.obolibrary.org/obo/PR_000001345` -#### Added -- [endoglin](http://purl.obolibrary.org/obo/PR_000001345) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [endoglin (human)](http://purl.obolibrary.org/obo/PR_P17813) +### common myeloid progenitor, CD34-positive `http://purl.obolibrary.org/obo/CL_0001059` +#### Removed +- [common myeloid progenitor, CD34-positive](http://purl.obolibrary.org/obo/CL_0001059) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "CFU-GEMM" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ISBN:0878932437" +- [common myeloid progenitor, CD34-positive](http://purl.obolibrary.org/obo/CL_0001059) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "CMP" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ISBN:0878932437" -### endothelial cell of respiratory system lymphatic vessel `http://purl.obolibrary.org/obo/CL_0009086` -#### Removed -- [endothelial cell of respiratory system lymphatic vessel](http://purl.obolibrary.org/obo/CL_0009086) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [respiratory system lymphatic vessel](http://purl.obolibrary.org/obo/UBERON_0003456) +- [common myeloid progenitor, CD34-positive](http://purl.obolibrary.org/obo/CL_0001059) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "CFU-S" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ISBN:0878932437" #### Added -- [endothelial cell of respiratory system lymphatic vessel](http://purl.obolibrary.org/obo/CL_0009086) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [respiratory system lymphatic vessel endothelium](http://purl.obolibrary.org/obo/UBERON_0003529) - +- [common myeloid progenitor, CD34-positive](http://purl.obolibrary.org/obo/CL_0001059) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "CMP" + - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation) -### endothelial transcription factor GATA-2 `http://purl.obolibrary.org/obo/PR_000007858` + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ISBN:0878932437" -#### Added -- [endothelial transcription factor GATA-2](http://purl.obolibrary.org/obo/PR_000007858) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [endothelial transcription factor GATA-2 (human)](http://purl.obolibrary.org/obo/PR_P23769) +- [common myeloid progenitor, CD34-positive](http://purl.obolibrary.org/obo/CL_0001059) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "CFU-S" + - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation) + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ISBN:0878932437" -### enteric nervous system `http://purl.obolibrary.org/obo/UBERON_0002005` -#### Removed -- [enteric nervous system](http://purl.obolibrary.org/obo/UBERON_0002005) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [common myeloid progenitor, CD34-positive](http://purl.obolibrary.org/obo/CL_0001059) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "CFU-GEMM" + - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation) + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ISBN:0878932437" -### entire embryonic mesenchyme `http://purl.obolibrary.org/obo/UBERON_0009142` +### contained in `http://purl.obolibrary.org/obo/RO_0001018` #### Removed -- [entire embryonic mesenchyme](http://purl.obolibrary.org/obo/UBERON_0009142) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [contained in](http://purl.obolibrary.org/obo/RO_0001018) [RO_0001900](http://purl.obolibrary.org/obo/RO_0001900) [RO_0001901](http://purl.obolibrary.org/obo/RO_0001901) +- [contained in](http://purl.obolibrary.org/obo/RO_0001018) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [ro-eco](http://purl.obolibrary.org/obo/ro/subsets#ro-eco) +- [contained in](http://purl.obolibrary.org/obo/RO_0001018) [label](http://www.w3.org/2000/01/rdf-schema#label) "contained in"@en -### enveloping layer of ectoderm `http://purl.obolibrary.org/obo/UBERON_0007383` -#### Removed -- [enveloping layer of ectoderm](http://purl.obolibrary.org/obo/UBERON_0007383) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [contained in](http://purl.obolibrary.org/obo/RO_0001018) [editor note](http://purl.obolibrary.org/obo/IAO_0000116) "Containment is location not involving parthood, and arises only where some immaterial continuant is involved." +- [contained in](http://purl.obolibrary.org/obo/RO_0001018) [IAO_0000118](http://purl.obolibrary.org/obo/IAO_0000118) "contained_in"@en +- [contained in](http://purl.obolibrary.org/obo/RO_0001018) [editor note](http://purl.obolibrary.org/obo/IAO_0000116) "Intended meaning: +domain: material entity +range: spatial region or site (immaterial continuant) + "@en -### eosinophil cationic protein `http://purl.obolibrary.org/obo/PR_000014047` +- [contained in](http://purl.obolibrary.org/obo/RO_0001018) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "contained in"@en -#### Added -- [eosinophil cationic protein](http://purl.obolibrary.org/obo/PR_000014047) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [eosinophil cationic protein (human)](http://purl.obolibrary.org/obo/PR_P12724) +- [contained in](http://purl.obolibrary.org/obo/RO_0001018) [editor note](http://purl.obolibrary.org/obo/IAO_0000116) "Containment obtains in each case between material and immaterial continuants, for instance: lung contained_in thoracic cavity; bladder contained_in pelvic cavity. Hence containment is not a transitive relation. If c part_of c1 at t then we have also, by our definition and by the axioms of mereology applied to spatial regions, c located_in c1 at t. Thus, many examples of instance-level location relations for continuants are in fact cases of instance-level parthood. For material continuants location and parthood coincide. Containment is location not involving parthood, and arises only where some immaterial continuant is involved. To understand this relation, we first define overlap for continuants as follows: c1 overlap c2 at t =def for some c, c part_of c1 at t and c part_of c2 at t. The containment relation on the instance level can then be defined (see definition):"@en +- ObjectProperty: [contained in](http://purl.obolibrary.org/obo/RO_0001018) -### eosinophil peroxidase `http://purl.obolibrary.org/obo/PR_000007152` +- [contained in](http://purl.obolibrary.org/obo/RO_0001018) InverseOf [contains](http://purl.obolibrary.org/obo/RO_0001019) -#### Added -- [eosinophil peroxidase](http://purl.obolibrary.org/obo/PR_000007152) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [eosinophil peroxidase (human)](http://purl.obolibrary.org/obo/PR_P11678) +- [contained in](http://purl.obolibrary.org/obo/RO_0001018) Domain [material entity](http://purl.obolibrary.org/obo/BFO_0000040) +- [contained in](http://purl.obolibrary.org/obo/RO_0001018) Range [independent continuant](http://purl.obolibrary.org/obo/BFO_0000004) -### eosinophil progenitor cell `http://purl.obolibrary.org/obo/CL_0000611` -#### Removed -- [eosinophil progenitor cell](http://purl.obolibrary.org/obo/CL_0000611) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [located in](http://purl.obolibrary.org/obo/RO_0001025) o [part_of](http://purl.obolibrary.org/obo/BFO_0000050) SubPropertyOf: [contained in](http://purl.obolibrary.org/obo/RO_0001018) -### epicardium `http://purl.obolibrary.org/obo/UBERON_0002348` +### contains `http://purl.obolibrary.org/obo/RO_0001019` #### Removed -- [epicardium](http://purl.obolibrary.org/obo/UBERON_0002348) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000) +- [contains](http://purl.obolibrary.org/obo/RO_0001019) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [ro-eco](http://purl.obolibrary.org/obo/ro/subsets#ro-eco) +- [contains](http://purl.obolibrary.org/obo/RO_0001019) [label](http://www.w3.org/2000/01/rdf-schema#label) "contains"@en +- [contains](http://purl.obolibrary.org/obo/RO_0001019) [RO_0001900](http://purl.obolibrary.org/obo/RO_0001900) [RO_0001901](http://purl.obolibrary.org/obo/RO_0001901) -### epiphyseal tract `http://purl.obolibrary.org/obo/UBERON_0034714` -#### Removed -- [epiphyseal tract](http://purl.obolibrary.org/obo/UBERON_0034714) SubClassOf [neuron projection bundle](http://purl.obolibrary.org/obo/CARO_0001001) +#### Added +- [contains](http://purl.obolibrary.org/obo/RO_0001019) [deprecated](http://www.w3.org/2002/07/owl#deprecated) true + +- [contains](http://purl.obolibrary.org/obo/RO_0001019) [label](http://www.w3.org/2000/01/rdf-schema#label) "obsolete contains" +- [contains](http://purl.obolibrary.org/obo/RO_0001019) [see also](http://www.w3.org/2000/01/rdf-schema#seeAlso) [693](https://github.com/oborel/obo-relations/issues/693) -### epithelial cell of pancreas `http://purl.obolibrary.org/obo/CL_0000083` +### corneal endothelial cell `http://purl.obolibrary.org/obo/CL_0000132` #### Removed -- [epithelial cell of pancreas](http://purl.obolibrary.org/obo/CL_0000083) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [corneal endothelial cell](http://purl.obolibrary.org/obo/CL_0000132) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "An hexagonal, flattened, mitochondria-rich endothelial cell that forms a monolayer on the posterior surface of the cornea (the corneal endothelium). Corneal endothelial cells are derived from the neural crest and are responsible for keeping the cornea transparent by maintaining the tissue in a semi-dry state through the action of their ionic pumps and tight junction barrier." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:tfm" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:36769303" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "MESH:A09.371.060.067.31" -### epithelium of appendix `http://purl.obolibrary.org/obo/UBERON_0009697` -#### Removed -- [epithelium of appendix](http://purl.obolibrary.org/obo/UBERON_0009697) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:34741068" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:23284695" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:21976958" -### epithelium of bronchus `http://purl.obolibrary.org/obo/UBERON_0002031` -#### Removed -- [epithelium of bronchus](http://purl.obolibrary.org/obo/UBERON_0002031) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +#### Added +- [corneal endothelial cell](http://purl.obolibrary.org/obo/CL_0000132) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "An hexagonal, flattened, mitochondria-rich endothelial cell that forms a monolayer on the posterior surface of the cornea (the corneal endothelium). Corneal endothelial cells are derived from the neural crest and are responsible for keeping the cornea transparent by maintaining the tissue in a semi-dry state through the action of their ionic pumps and tight junction barrier." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:tfm" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:36769303" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:34741068" -### epithelium of carpal region `http://purl.obolibrary.org/obo/UBERON_0003230` -#### Removed -- [epithelium of carpal region](http://purl.obolibrary.org/obo/UBERON_0003230) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:23284695" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:21976958" -### epithelium of elbow `http://purl.obolibrary.org/obo/UBERON_0003229` +### correlated with `http://purl.obolibrary.org/obo/RO_0002610` #### Removed -- [epithelium of elbow](http://purl.obolibrary.org/obo/UBERON_0003229) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [correlated with](http://purl.obolibrary.org/obo/RO_0002610) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A relationship that holds between two entities, where the entities exhibit a statistical dependence relationship. The entities may be statistical variables, or they may be other kinds of entities such as diseases, chemical entities or processes." +- [correlated with](http://purl.obolibrary.org/obo/RO_0002610) [label](http://www.w3.org/2000/01/rdf-schema#label) "correlated with" +- [correlated with](http://purl.obolibrary.org/obo/RO_0002610) [IAO_0000232](http://purl.obolibrary.org/obo/IAO_0000232) "Groups both positive and negative correlation" -### epithelium of footplate `http://purl.obolibrary.org/obo/UBERON_0003248` -#### Removed -- [epithelium of footplate](http://purl.obolibrary.org/obo/UBERON_0003248) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- ObjectProperty: [correlated with](http://purl.obolibrary.org/obo/RO_0002610) -### epithelium of forearm `http://purl.obolibrary.org/obo/UBERON_0003247` +### curation status specification `http://purl.obolibrary.org/obo/IAO_0000078` #### Removed -- [epithelium of forearm](http://purl.obolibrary.org/obo/UBERON_0003247) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) - +- [curation status specification](http://purl.obolibrary.org/obo/IAO_0000078) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "curation status specification"@en +- [curation status specification](http://purl.obolibrary.org/obo/IAO_0000078) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The curation status of the term. The allowed values come from an enumerated list of predefined terms. See the specification of these instances for more detailed definitions of each enumerated value."@en -### epithelium of handplate `http://purl.obolibrary.org/obo/UBERON_0010332` -#### Removed -- [epithelium of handplate](http://purl.obolibrary.org/obo/UBERON_0010332) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [curation status specification](http://purl.obolibrary.org/obo/IAO_0000078) [label](http://www.w3.org/2000/01/rdf-schema#label) "curation status specification"@en +- [curation status specification](http://purl.obolibrary.org/obo/IAO_0000078) [IAO_0000117](http://purl.obolibrary.org/obo/IAO_0000117) "PERSON:Bill Bug"@en +- [curation status specification](http://purl.obolibrary.org/obo/IAO_0000078) [IAO_0000119](http://purl.obolibrary.org/obo/IAO_0000119) "OBI_0000266"@en -### epithelium of hip `http://purl.obolibrary.org/obo/UBERON_0003231` -#### Removed -- [epithelium of hip](http://purl.obolibrary.org/obo/UBERON_0003231) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [curation status specification](http://purl.obolibrary.org/obo/IAO_0000078) [IAO_0000114](http://purl.obolibrary.org/obo/IAO_0000114) [pending final vetting](http://purl.obolibrary.org/obo/IAO_0000125) +- [curation status specification](http://purl.obolibrary.org/obo/IAO_0000078) [IAO_0000119](http://purl.obolibrary.org/obo/IAO_0000119) "GROUP:OBI:<http://purl.obolibrary.org/obo/obi>"@en +- [curation status specification](http://purl.obolibrary.org/obo/IAO_0000078) [editor note](http://purl.obolibrary.org/obo/IAO_0000116) "Better to represent curation as a process with parts and then relate labels to that process (in IAO meeting)"@en -### epithelium of knee `http://purl.obolibrary.org/obo/UBERON_0003232` -#### Removed -- [epithelium of knee](http://purl.obolibrary.org/obo/UBERON_0003232) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- Class: [curation status specification](http://purl.obolibrary.org/obo/IAO_0000078) +- [curation status specification](http://purl.obolibrary.org/obo/IAO_0000078) EquivalentTo {[example to be eventually removed](http://purl.obolibrary.org/obo/IAO_0000002) , [metadata complete](http://purl.obolibrary.org/obo/IAO_0000120) , [organizational term](http://purl.obolibrary.org/obo/IAO_0000121) , [ready for release](http://purl.obolibrary.org/obo/IAO_0000122) , [metadata incomplete](http://purl.obolibrary.org/obo/IAO_0000123) , [uncurated](http://purl.obolibrary.org/obo/IAO_0000124) , [pending final vetting](http://purl.obolibrary.org/obo/IAO_0000125) , [to be replaced with external ontology term](http://purl.obolibrary.org/obo/IAO_0000423) , [requires discussion](http://purl.obolibrary.org/obo/IAO_0000428)} +- [curation status specification](http://purl.obolibrary.org/obo/IAO_0000078) SubClassOf [data about an ontology part](http://purl.obolibrary.org/obo/IAO_0000102) -### epithelium of mammary gland `http://purl.obolibrary.org/obo/UBERON_0003244` -#### Removed -- [epithelium of mammary gland](http://purl.obolibrary.org/obo/UBERON_0003244) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +### cytoplasmic translation `http://purl.obolibrary.org/obo/GO_0002181` -### epithelium of respiratory bronchiole `http://purl.obolibrary.org/obo/UBERON_0001955` -#### Removed -- [epithelium of respiratory bronchiole](http://purl.obolibrary.org/obo/UBERON_0001955) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +#### Added +- [cytoplasmic translation](http://purl.obolibrary.org/obo/GO_0002181) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [goslim_pombe](http://purl.obolibrary.org/obo/go#goslim_pombe) +- [cytoplasmic translation](http://purl.obolibrary.org/obo/GO_0002181) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:hjd" +- [cytoplasmic translation](http://purl.obolibrary.org/obo/GO_0002181) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [goslim_generic](http://purl.obolibrary.org/obo/go#goslim_generic) -### epithelium of saccule `http://purl.obolibrary.org/obo/UBERON_0003242` -#### Removed -- [epithelium of saccule](http://purl.obolibrary.org/obo/UBERON_0003242) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [cytoplasmic translation](http://purl.obolibrary.org/obo/GO_0002181) [label](http://www.w3.org/2000/01/rdf-schema#label) "cytoplasmic translation" +- [cytoplasmic translation](http://purl.obolibrary.org/obo/GO_0002181) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [goslim_yeast](http://purl.obolibrary.org/obo/go#goslim_yeast) +- [cytoplasmic translation](http://purl.obolibrary.org/obo/GO_0002181) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "Note that this term applies to translation performed by cytoplasmic ribosomes, which is distinct from translation performed by organellar ribosomes. For mitochondrial translation, consider GO:0032543 'mitochondrial translation' or its child terms." -### epithelium of shoulder `http://purl.obolibrary.org/obo/UBERON_0003233` -#### Removed -- [epithelium of shoulder](http://purl.obolibrary.org/obo/UBERON_0003233) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [cytoplasmic translation](http://purl.obolibrary.org/obo/GO_0002181) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" +- [cytoplasmic translation](http://purl.obolibrary.org/obo/GO_0002181) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0002181" +- [cytoplasmic translation](http://purl.obolibrary.org/obo/GO_0002181) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "hjd" -### epithelium of utricle `http://purl.obolibrary.org/obo/UBERON_0003241` -#### Removed -- [epithelium of utricle](http://purl.obolibrary.org/obo/UBERON_0003241) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [cytoplasmic translation](http://purl.obolibrary.org/obo/GO_0002181) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2011-06-09T03:11:53Z" +- Class: [cytoplasmic translation](http://purl.obolibrary.org/obo/GO_0002181) +- [cytoplasmic translation](http://purl.obolibrary.org/obo/GO_0002181) EquivalentTo [translation](http://purl.obolibrary.org/obo/GO_0006412) and ([process has causal agent](http://purl.obolibrary.org/obo/RO_0002608) some [cytosolic ribosome](http://purl.obolibrary.org/obo/GO_0022626)) -### erythroid progenitor cell, mammalian `http://purl.obolibrary.org/obo/CL_0001066` -#### Removed -- [erythroid progenitor cell, mammalian](http://purl.obolibrary.org/obo/CL_0001066) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [cytoplasmic translation](http://purl.obolibrary.org/obo/GO_0002181) SubClassOf [process has causal agent](http://purl.obolibrary.org/obo/RO_0002608) some [cytosolic ribosome](http://purl.obolibrary.org/obo/GO_0022626) +- [cytoplasmic translation](http://purl.obolibrary.org/obo/GO_0002181) SubClassOf [translation](http://purl.obolibrary.org/obo/GO_0006412) -### erythroid transcription factor `http://purl.obolibrary.org/obo/PR_000007857` +### cytoplasmic translational elongation `http://purl.obolibrary.org/obo/GO_0002182` #### Added -- [erythroid transcription factor](http://purl.obolibrary.org/obo/PR_000007857) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [erythroid transcription factor (human)](http://purl.obolibrary.org/obo/PR_P15976) +- [cytoplasmic translational elongation](http://purl.obolibrary.org/obo/GO_0002182) [label](http://www.w3.org/2000/01/rdf-schema#label) "cytoplasmic translational elongation" +- [cytoplasmic translational elongation](http://purl.obolibrary.org/obo/GO_0002182) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" -### erythrophore `http://purl.obolibrary.org/obo/CL_0000574` -#### Removed -- [erythrophore](http://purl.obolibrary.org/obo/CL_0000574) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [cytoplasmic translational elongation](http://purl.obolibrary.org/obo/GO_0002182) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2011-06-09T03:14:42Z" +- [cytoplasmic translational elongation](http://purl.obolibrary.org/obo/GO_0002182) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis in the cytoplasm." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:hjd" +- [cytoplasmic translational elongation](http://purl.obolibrary.org/obo/GO_0002182) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "hjd" -### ethmoid bone primordium `http://purl.obolibrary.org/obo/UBERON_0006227` -#### Removed -- [ethmoid bone primordium](http://purl.obolibrary.org/obo/UBERON_0006227) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [cytoplasmic translational elongation](http://purl.obolibrary.org/obo/GO_0002182) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0002182" +- Class: [cytoplasmic translational elongation](http://purl.obolibrary.org/obo/GO_0002182) +- [cytoplasmic translational elongation](http://purl.obolibrary.org/obo/GO_0002182) EquivalentTo [translational elongation](http://purl.obolibrary.org/obo/GO_0006414) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [cytoplasmic translation](http://purl.obolibrary.org/obo/GO_0002181)) -### ethmoid region `http://purl.obolibrary.org/obo/UBERON_0011241` -#### Removed -- [ethmoid region](http://purl.obolibrary.org/obo/UBERON_0011241) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [cytoplasmic translational elongation](http://purl.obolibrary.org/obo/GO_0002182) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [cytoplasmic translation](http://purl.obolibrary.org/obo/GO_0002181) +- [cytoplasmic translational elongation](http://purl.obolibrary.org/obo/GO_0002182) SubClassOf [translational elongation](http://purl.obolibrary.org/obo/GO_0006414) -### example to be eventually removed `http://purl.obolibrary.org/obo/IAO_0000002` +### cytoplasmic translational initiation `http://purl.obolibrary.org/obo/GO_0002183` #### Added -- [example to be eventually removed](http://purl.obolibrary.org/obo/IAO_0000002) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "example to be eventually removed"@en +- [cytoplasmic translational initiation](http://purl.obolibrary.org/obo/GO_0002183) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2011-06-09T03:15:48Z" -- [example to be eventually removed](http://purl.obolibrary.org/obo/IAO_0000002) [label](http://www.w3.org/2000/01/rdf-schema#label) "example to be eventually removed"@en +- [cytoplasmic translational initiation](http://purl.obolibrary.org/obo/GO_0002183) [label](http://www.w3.org/2000/01/rdf-schema#label) "cytoplasmic translational initiation" -- Individual: [example to be eventually removed](http://purl.obolibrary.org/obo/IAO_0000002) +- [cytoplasmic translational initiation](http://purl.obolibrary.org/obo/GO_0002183) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0002183" +- [cytoplasmic translational initiation](http://purl.obolibrary.org/obo/GO_0002183) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "hjd" -### expand expression to `http://purl.obolibrary.org/obo/IAO_0000424` +- [cytoplasmic translational initiation](http://purl.obolibrary.org/obo/GO_0002183) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" -#### Added -- [expand expression to](http://purl.obolibrary.org/obo/IAO_0000424) [IAO_0000112](http://purl.obolibrary.org/obo/IAO_0000112) "ObjectProperty: RO_0002104 -Label: has plasma membrane part -Annotations: IAO_0000424 "http://purl.obolibrary.org/obo/BFO_0000051 some (http://purl.org/obo/owl/GO#GO_0005886 and http://purl.obolibrary.org/obo/BFO_0000051 some ?Y)" -"@en +- [cytoplasmic translational initiation](http://purl.obolibrary.org/obo/GO_0002183) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The process preceding formation of the peptide bond between the first two amino acids of a protein in the cytoplasm. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:hjd" -- [expand expression to](http://purl.obolibrary.org/obo/IAO_0000424) [label](http://www.w3.org/2000/01/rdf-schema#label) "expand expression to"@en +- Class: [cytoplasmic translational initiation](http://purl.obolibrary.org/obo/GO_0002183) -- [expand expression to](http://purl.obolibrary.org/obo/IAO_0000424) [IAO_0000117](http://purl.obolibrary.org/obo/IAO_0000117) "Chris Mungall"@en +- [cytoplasmic translational initiation](http://purl.obolibrary.org/obo/GO_0002183) EquivalentTo [translational initiation](http://purl.obolibrary.org/obo/GO_0006413) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [cytoplasmic translation](http://purl.obolibrary.org/obo/GO_0002181)) -- [expand expression to](http://purl.obolibrary.org/obo/IAO_0000424) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "expand expression to"@en +- [cytoplasmic translational initiation](http://purl.obolibrary.org/obo/GO_0002183) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [cytoplasmic translation](http://purl.obolibrary.org/obo/GO_0002181) -- [expand expression to](http://purl.obolibrary.org/obo/IAO_0000424) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A macro expansion tag applied to an object property (or possibly a data property) which can be used by a macro-expansion engine to generate more complex expressions from simpler ones"@en +- [cytoplasmic translational initiation](http://purl.obolibrary.org/obo/GO_0002183) SubClassOf [translational initiation](http://purl.obolibrary.org/obo/GO_0006413) -### expressed in `http://purl.obolibrary.org/obo/RO_0002206` -#### Removed -- [expressed in](http://purl.obolibrary.org/obo/RO_0002206) Range [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +### cytoplasmic translational termination `http://purl.obolibrary.org/obo/GO_0002184` #### Added -- [expressed in](http://purl.obolibrary.org/obo/RO_0002206) Range [material anatomical entity](http://purl.obolibrary.org/obo/UBERON_0000465) +- [cytoplasmic translational termination](http://purl.obolibrary.org/obo/GO_0002184) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "hjd" +- [cytoplasmic translational termination](http://purl.obolibrary.org/obo/GO_0002184) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2011-06-09T03:17:13Z" -### expresses `http://purl.obolibrary.org/obo/RO_0002292` -#### Removed -- [expresses](http://purl.obolibrary.org/obo/RO_0002292) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Inverse of 'expressed in'" +- [cytoplasmic translational termination](http://purl.obolibrary.org/obo/GO_0002184) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" -#### Added -- [expresses](http://purl.obolibrary.org/obo/RO_0002292) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "y expresses x if and only if there is a gene expression process (GO:0010467) that occurs in y, and one of the following holds: (i) x is a gene, and x is transcribed into a transcript as part of the gene expression process (ii) x is a transcript, and x was transcribed from a gene as part of the gene expression process (iii) x is a mature gene product (protein or RNA), and x was translated or otherwise processed from a transcript that was transcribed as part of the gene expression process." +- [cytoplasmic translational termination](http://purl.obolibrary.org/obo/GO_0002184) [label](http://www.w3.org/2000/01/rdf-schema#label) "cytoplasmic translational termination" +- [cytoplasmic translational termination](http://purl.obolibrary.org/obo/GO_0002184) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The process resulting in the release of a polypeptide chain from the ribosome in the cytoplasm, usually in response to a termination codon." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:hjd" -### external acoustic meatus `http://purl.obolibrary.org/obo/UBERON_0001352` -#### Removed -- [external acoustic meatus](http://purl.obolibrary.org/obo/UBERON_0001352) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [cytoplasmic translational termination](http://purl.obolibrary.org/obo/GO_0002184) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0002184" +- Class: [cytoplasmic translational termination](http://purl.obolibrary.org/obo/GO_0002184) +- [cytoplasmic translational termination](http://purl.obolibrary.org/obo/GO_0002184) EquivalentTo [translational termination](http://purl.obolibrary.org/obo/GO_0006415) and ([occurs in](http://purl.obolibrary.org/obo/BFO_0000066) some [cytosol](http://purl.obolibrary.org/obo/GO_0005829)) -### external soft tissue zone `http://purl.obolibrary.org/obo/UBERON_0034929` -#### Removed -- [external soft tissue zone](http://purl.obolibrary.org/obo/UBERON_0034929) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [cytoplasmic translational termination](http://purl.obolibrary.org/obo/GO_0002184) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [cytoplasmic translation](http://purl.obolibrary.org/obo/GO_0002181) + +- [cytoplasmic translational termination](http://purl.obolibrary.org/obo/GO_0002184) SubClassOf [occurs in](http://purl.obolibrary.org/obo/BFO_0000066) some [cytosol](http://purl.obolibrary.org/obo/GO_0005829) +- [cytoplasmic translational termination](http://purl.obolibrary.org/obo/GO_0002184) SubClassOf [translational termination](http://purl.obolibrary.org/obo/GO_0006415) -### extratelencephalic-projecting glutamatergic cortical neuron `http://purl.obolibrary.org/obo/CL_4023009` +### cytoplasmic transport, nurse cell to oocyte `http://purl.obolibrary.org/obo/GO_0007303` #### Added -- [extratelencephalic-projecting glutamatergic cortical neuron](http://purl.obolibrary.org/obo/CL_4023009) [symbol](http://purl.obolibrary.org/obo/IAO_0000028) "ET glut" +- [cytoplasmic transport, nurse cell to oocyte](http://purl.obolibrary.org/obo/GO_0007303) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0007303" +- [cytoplasmic transport, nurse cell to oocyte](http://purl.obolibrary.org/obo/GO_0007303) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" -### eye mesenchyme `http://purl.obolibrary.org/obo/UBERON_0003314` -#### Removed -- [eye mesenchyme](http://purl.obolibrary.org/obo/UBERON_0003314) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [cytoplasmic transport, nurse cell to oocyte](http://purl.obolibrary.org/obo/GO_0007303) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The directed movement of cytoplasmic constituents synthesized in the nurse cells to the oocyte." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ISBN:0879694238" +- [cytoplasmic transport, nurse cell to oocyte](http://purl.obolibrary.org/obo/GO_0007303) [label](http://www.w3.org/2000/01/rdf-schema#label) "cytoplasmic transport, nurse cell to oocyte" +- Class: [cytoplasmic transport, nurse cell to oocyte](http://purl.obolibrary.org/obo/GO_0007303) -### eye trabecular meshwork `http://purl.obolibrary.org/obo/UBERON_0005969` -#### Removed -- [eye trabecular meshwork](http://purl.obolibrary.org/obo/UBERON_0005969) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [cytoplasmic transport, nurse cell to oocyte](http://purl.obolibrary.org/obo/GO_0007303) EquivalentTo [cytosolic transport](http://purl.obolibrary.org/obo/GO_0016482) and ([has target start location](http://purl.obolibrary.org/obo/RO_0002338) some [invertebrate nurse cell](http://purl.obolibrary.org/obo/CL_0000026)) and ([has target end location](http://purl.obolibrary.org/obo/RO_0002339) some [oocyte](http://purl.obolibrary.org/obo/CL_0000023)) +- [cytoplasmic transport, nurse cell to oocyte](http://purl.obolibrary.org/obo/GO_0007303) SubClassOf [has target start location](http://purl.obolibrary.org/obo/RO_0002338) some [invertebrate nurse cell](http://purl.obolibrary.org/obo/CL_0000026) +- [cytoplasmic transport, nurse cell to oocyte](http://purl.obolibrary.org/obo/GO_0007303) SubClassOf [cellular process involved in reproduction in multicellular organism](http://purl.obolibrary.org/obo/GO_0022412) -### eyelid nerve `http://purl.obolibrary.org/obo/UBERON_0003437` -#### Removed -- [eyelid nerve](http://purl.obolibrary.org/obo/UBERON_0003437) SubClassOf [neuron projection bundle](http://purl.obolibrary.org/obo/CARO_0001001) +- [cytoplasmic transport, nurse cell to oocyte](http://purl.obolibrary.org/obo/GO_0007303) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [ovarian nurse cell to oocyte transport](http://purl.obolibrary.org/obo/GO_0007300) +- [cytoplasmic transport, nurse cell to oocyte](http://purl.obolibrary.org/obo/GO_0007303) SubClassOf [cytosolic transport](http://purl.obolibrary.org/obo/GO_0016482) +- [cytoplasmic transport, nurse cell to oocyte](http://purl.obolibrary.org/obo/GO_0007303) SubClassOf [has target end location](http://purl.obolibrary.org/obo/RO_0002339) some [oocyte](http://purl.obolibrary.org/obo/CL_0000023) -### fMet-Leu-Phe receptor `http://purl.obolibrary.org/obo/PR_000001580` -#### Added -- [fMet-Leu-Phe receptor](http://purl.obolibrary.org/obo/PR_000001580) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [fMet-Leu-Phe receptor (human)](http://purl.obolibrary.org/obo/PR_P21462) +### cytoskeleton-dependent cytoplasmic transport, nurse cell to oocyte `http://purl.obolibrary.org/obo/GO_0019749` +#### Added +- [cytoskeleton-dependent cytoplasmic transport, nurse cell to oocyte](http://purl.obolibrary.org/obo/GO_0019749) [label](http://www.w3.org/2000/01/rdf-schema#label) "cytoskeleton-dependent cytoplasmic transport, nurse cell to oocyte" -### face `http://purl.obolibrary.org/obo/UBERON_0001456` -#### Removed -- [face](http://purl.obolibrary.org/obo/UBERON_0001456) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [cytoskeleton-dependent cytoplasmic transport, nurse cell to oocyte](http://purl.obolibrary.org/obo/GO_0019749) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" +- [cytoskeleton-dependent cytoplasmic transport, nurse cell to oocyte](http://purl.obolibrary.org/obo/GO_0019749) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0019749" +- [cytoskeleton-dependent cytoplasmic transport, nurse cell to oocyte](http://purl.obolibrary.org/obo/GO_0019749) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The directed movement of substances along cytoskeletal elements, such as microfilaments or microtubules, from a nurse cell to an oocyte." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:ai" -### facial nerve `http://purl.obolibrary.org/obo/UBERON_0001647` -#### Removed -- [facial nerve](http://purl.obolibrary.org/obo/UBERON_0001647) SubClassOf [neuron projection bundle](http://purl.obolibrary.org/obo/CARO_0001001) +- Class: [cytoskeleton-dependent cytoplasmic transport, nurse cell to oocyte](http://purl.obolibrary.org/obo/GO_0019749) +- [cytoskeleton-dependent cytoplasmic transport, nurse cell to oocyte](http://purl.obolibrary.org/obo/GO_0019749) EquivalentTo [cytoplasmic transport, nurse cell to oocyte](http://purl.obolibrary.org/obo/GO_0007303) and [cytoskeleton-dependent intracellular transport](http://purl.obolibrary.org/obo/GO_0030705) +- [cytoskeleton-dependent cytoplasmic transport, nurse cell to oocyte](http://purl.obolibrary.org/obo/GO_0019749) SubClassOf [cytoskeleton-dependent intracellular transport](http://purl.obolibrary.org/obo/GO_0030705) -### facial skeleton `http://purl.obolibrary.org/obo/UBERON_0011156` -#### Removed -- [facial skeleton](http://purl.obolibrary.org/obo/UBERON_0011156) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [cytoskeleton-dependent cytoplasmic transport, nurse cell to oocyte](http://purl.obolibrary.org/obo/GO_0019749) SubClassOf [cytoplasmic transport, nurse cell to oocyte](http://purl.obolibrary.org/obo/GO_0007303) +### cytosol `http://purl.obolibrary.org/obo/GO_0005829` -### facio-acoustic VII-VIII preganglion complex `http://purl.obolibrary.org/obo/UBERON_0006232` -#### Removed -- [facio-acoustic VII-VIII preganglion complex](http://purl.obolibrary.org/obo/UBERON_0006232) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +#### Added +- [cytosol](http://purl.obolibrary.org/obo/GO_0005829) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "cellular_component" +- [cytosol](http://purl.obolibrary.org/obo/GO_0005829) [label](http://www.w3.org/2000/01/rdf-schema#label) "cytosol" +- [cytosol](http://purl.obolibrary.org/obo/GO_0005829) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [goslim_agr](http://purl.obolibrary.org/obo/go#goslim_agr) -### failed exploratory term `http://purl.obolibrary.org/obo/IAO_0000103` +- [cytosol](http://purl.obolibrary.org/obo/GO_0005829) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0005829" -#### Added -- [failed exploratory term](http://purl.obolibrary.org/obo/IAO_0000103) [label](http://www.w3.org/2000/01/rdf-schema#label) "failed exploratory term"@en +- [cytosol](http://purl.obolibrary.org/obo/GO_0005829) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [goslim_generic](http://purl.obolibrary.org/obo/go#goslim_generic) -- [failed exploratory term](http://purl.obolibrary.org/obo/IAO_0000103) [IAO_0000117](http://purl.obolibrary.org/obo/IAO_0000117) "Person:Alan Ruttenberg"@en +- [cytosol](http://purl.obolibrary.org/obo/GO_0005829) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [goslim_mouse](http://purl.obolibrary.org/obo/go#goslim_mouse) -- [failed exploratory term](http://purl.obolibrary.org/obo/IAO_0000103) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "failed exploratory term"@en +- [cytosol](http://purl.obolibrary.org/obo/GO_0005829) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [goslim_plant](http://purl.obolibrary.org/obo/go#goslim_plant) -- [failed exploratory term](http://purl.obolibrary.org/obo/IAO_0000103) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The term was used in an attempt to structure part of the ontology but in retrospect failed to do a good job"@en +- [cytosol](http://purl.obolibrary.org/obo/GO_0005829) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:jl" -- Individual: [failed exploratory term](http://purl.obolibrary.org/obo/IAO_0000103) + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:hjd" +- [cytosol](http://purl.obolibrary.org/obo/GO_0005829) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "NIF_Subcellular:sao101633890" -### fasciculates with `http://purl.obolibrary.org/obo/RO_0002101` -#### Removed -- [fasciculates with](http://purl.obolibrary.org/obo/RO_0002101) Range [neuron projection bundle](http://purl.obolibrary.org/obo/CARO_0001001) +- [cytosol](http://purl.obolibrary.org/obo/GO_0005829) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [goslim_drosophila](http://purl.obolibrary.org/obo/go#goslim_drosophila) -#### Added -- [fasciculates with](http://purl.obolibrary.org/obo/RO_0002101) Range [neuron projection bundle](http://purl.obolibrary.org/obo/UBERON_0000122) +- [cytosol](http://purl.obolibrary.org/obo/GO_0005829) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [goslim_chembl](http://purl.obolibrary.org/obo/go#goslim_chembl) +- [cytosol](http://purl.obolibrary.org/obo/GO_0005829) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [goslim_flybase_ribbon](http://purl.obolibrary.org/obo/go#goslim_flybase_ribbon) -### fat cell `http://purl.obolibrary.org/obo/CL_0000136` -#### Removed -- [fat cell](http://purl.obolibrary.org/obo/CL_0000136) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [cytosol](http://purl.obolibrary.org/obo/GO_0005829) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Wikipedia:Cytosol" +- Class: [cytosol](http://purl.obolibrary.org/obo/GO_0005829) +- [cytosol](http://purl.obolibrary.org/obo/GO_0005829) DisjointWith [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [organelle](http://purl.obolibrary.org/obo/GO_0043226) -### fetal liver hematopoietic progenitor cell `http://purl.obolibrary.org/obo/CL_0002353` -#### Removed -- [fetal liver hematopoietic progenitor cell](http://purl.obolibrary.org/obo/CL_0002353) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [cytosol](http://purl.obolibrary.org/obo/GO_0005829) DisjointWith [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [nucleus](http://purl.obolibrary.org/obo/GO_0005634) +- [cytosol](http://purl.obolibrary.org/obo/GO_0005829) SubClassOf [cellular anatomical entity](http://purl.obolibrary.org/obo/GO_0110165) +- [cytosol](http://purl.obolibrary.org/obo/GO_0005829) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [cytoplasm](http://purl.obolibrary.org/obo/GO_0005737) -### fibroblast `http://purl.obolibrary.org/obo/CL_0000057` -#### Removed -- [fibroblast](http://purl.obolibrary.org/obo/CL_0000057) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +### cytosol to Golgi apparatus transport `http://purl.obolibrary.org/obo/GO_0140820` +#### Added +- [cytosol to Golgi apparatus transport](http://purl.obolibrary.org/obo/GO_0140820) [label](http://www.w3.org/2000/01/rdf-schema#label) "cytosol to Golgi apparatus transport" -### fibroblast growth factor 8 `http://purl.obolibrary.org/obo/PR_000007499` +- [cytosol to Golgi apparatus transport](http://purl.obolibrary.org/obo/GO_0140820) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The directed movement of substances from the cytosol into the Golgi apparatus of a cell." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:28373556" -#### Added -- [fibroblast growth factor 8](http://purl.obolibrary.org/obo/PR_000007499) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [fibroblast growth factor 8 (human)](http://purl.obolibrary.org/obo/PR_P55075) +- [cytosol to Golgi apparatus transport](http://purl.obolibrary.org/obo/GO_0140820) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2022-05-16T06:59:22Z" +- [cytosol to Golgi apparatus transport](http://purl.obolibrary.org/obo/GO_0140820) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0140820" -### follicle cell of egg chamber `http://purl.obolibrary.org/obo/CL_0000477` -#### Removed -- [follicle cell of egg chamber](http://purl.obolibrary.org/obo/CL_0000477) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [cytosol to Golgi apparatus transport](http://purl.obolibrary.org/obo/GO_0140820) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "pg" +- [cytosol to Golgi apparatus transport](http://purl.obolibrary.org/obo/GO_0140820) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" +- [cytosol to Golgi apparatus transport](http://purl.obolibrary.org/obo/GO_0140820) [term tracker item](http://purl.obolibrary.org/obo/IAO_0000233) "https://github.com/geneontology/go-ontology/issues/21524"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI) -### follicular fluid `http://purl.obolibrary.org/obo/UBERON_0000038` -#### Removed -- [follicular fluid](http://purl.obolibrary.org/obo/UBERON_0000038) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- Class: [cytosol to Golgi apparatus transport](http://purl.obolibrary.org/obo/GO_0140820) +- [cytosol to Golgi apparatus transport](http://purl.obolibrary.org/obo/GO_0140820) EquivalentTo [transmembrane transport](http://purl.obolibrary.org/obo/GO_0055085) and ([has target start location](http://purl.obolibrary.org/obo/RO_0002338) some [cytosol](http://purl.obolibrary.org/obo/GO_0005829)) and ([has target end location](http://purl.obolibrary.org/obo/RO_0002339) some [Golgi apparatus](http://purl.obolibrary.org/obo/GO_0005794)) and ([results in transport across](http://purl.obolibrary.org/obo/RO_0002342) some [membrane](http://purl.obolibrary.org/obo/GO_0016020)) +- [cytosol to Golgi apparatus transport](http://purl.obolibrary.org/obo/GO_0140820) SubClassOf [has target start location](http://purl.obolibrary.org/obo/RO_0002338) some [cytosol](http://purl.obolibrary.org/obo/GO_0005829) -### folliculostellate cell `http://purl.obolibrary.org/obo/CL_0000642` -#### Removed -- [folliculostellate cell](http://purl.obolibrary.org/obo/CL_0000642) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A supportive cell of the vertebrate pituitary that provides macromolecular transport and secretes hormones." - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "JB:jb" +- [cytosol to Golgi apparatus transport](http://purl.obolibrary.org/obo/GO_0140820) SubClassOf [transmembrane transport](http://purl.obolibrary.org/obo/GO_0055085) -- [folliculostellate cell](http://purl.obolibrary.org/obo/CL_0000642) SubClassOf [endocrine cell](http://purl.obolibrary.org/obo/CL_0000163) +- [cytosol to Golgi apparatus transport](http://purl.obolibrary.org/obo/GO_0140820) SubClassOf [has target end location](http://purl.obolibrary.org/obo/RO_0002339) some [Golgi apparatus](http://purl.obolibrary.org/obo/GO_0005794) -#### Added -- [folliculostellate cell](http://purl.obolibrary.org/obo/CL_0000642) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "folliculo-stellate cell" - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.23937/2572-407X.1510006" -- [folliculostellate cell](http://purl.obolibrary.org/obo/CL_0000642) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "An agranular supporting cell of the anterior pituitary (adenohypophysis) that is characterized by a star-like morphology and ability to form follicles. Folliculostellate cells communicate with each other and with endocrine cells via gap junctions." - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:10495875" +### cytosolic lipolysis `http://purl.obolibrary.org/obo/GO_0061725` - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:15961560" +#### Added +- [cytosolic lipolysis](http://purl.obolibrary.org/obo/GO_0061725) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2015-07-08T13:42:15Z" - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.23937/2572-407X.1510006" +- [cytosolic lipolysis](http://purl.obolibrary.org/obo/GO_0061725) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0061725" - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "JB:jb" +- [cytosolic lipolysis](http://purl.obolibrary.org/obo/GO_0061725) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The chemical reactions and pathways resulting in the breakdown of lipid droplets and hydrolysis of stored triglycerides occurring through the orchestrated activation of cytosolic lipases." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:autophagy" -- [folliculostellate cell](http://purl.obolibrary.org/obo/CL_0000642) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "Folliculostellate cells are a heterogeneous group of cells rather than a single cell type, with different morphology and gene expression profiles. Due to this heterogeneity, it is unclear if different properties that have been attributed to folliculostellate cells (pluripotent, proliferative, phagocytic) are common in all folliculostellate cells or limited to particular subsets." - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:31620083" +- [cytosolic lipolysis](http://purl.obolibrary.org/obo/GO_0061725) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:34734454" +- [cytosolic lipolysis](http://purl.obolibrary.org/obo/GO_0061725) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "dph" - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.23937/2572-407X.1510006" +- [cytosolic lipolysis](http://purl.obolibrary.org/obo/GO_0061725) [label](http://www.w3.org/2000/01/rdf-schema#label) "cytosolic lipolysis" - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:18287078" +- Class: [cytosolic lipolysis](http://purl.obolibrary.org/obo/GO_0061725) -- [folliculostellate cell](http://purl.obolibrary.org/obo/CL_0000642) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "Sox2-positive stem cell" - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:34734454" +- [cytosolic lipolysis](http://purl.obolibrary.org/obo/GO_0061725) EquivalentTo [catabolic process](http://purl.obolibrary.org/obo/GO_0009056) and ([occurs in](http://purl.obolibrary.org/obo/BFO_0000066) some [cytosol](http://purl.obolibrary.org/obo/GO_0005829)) and ([has primary input](http://purl.obolibrary.org/obo/RO_0004009) some [CHEBI_18059](http://purl.obolibrary.org/obo/CHEBI_18059)) -- [folliculostellate cell](http://purl.obolibrary.org/obo/CL_0000642) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "FSC" - - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation) +- [cytosolic lipolysis](http://purl.obolibrary.org/obo/GO_0061725) SubClassOf [cellular lipid catabolic process](http://purl.obolibrary.org/obo/GO_0044242) - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.23937/2572-407X.1510006" +- [cytosolic lipolysis](http://purl.obolibrary.org/obo/GO_0061725) SubClassOf [occurs in](http://purl.obolibrary.org/obo/BFO_0000066) some [cytosol](http://purl.obolibrary.org/obo/GO_0005829) -- [folliculostellate cell](http://purl.obolibrary.org/obo/CL_0000642) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "pituitary folliculostellate cell" - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:34734454" -- [folliculostellate cell](http://purl.obolibrary.org/obo/CL_0000642) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "FS cell" - - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation) +### cytosolic region `http://purl.obolibrary.org/obo/GO_0099522` - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:34734454" +#### Added +- [cytosolic region](http://purl.obolibrary.org/obo/GO_0099522) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "region of cytosol" -- [folliculostellate cell](http://purl.obolibrary.org/obo/CL_0000642) SubClassOf [paracrine cell](http://purl.obolibrary.org/obo/CL_0000512) +- [cytosolic region](http://purl.obolibrary.org/obo/GO_0099522) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any (proper) part of the cytosol of a single cell of sufficient size to still be considered cytosol." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dos" -- [folliculostellate cell](http://purl.obolibrary.org/obo/CL_0000642) SubClassOf [pituitary gland cell](http://purl.obolibrary.org/obo/CL_2000004) +- [cytosolic region](http://purl.obolibrary.org/obo/GO_0099522) [label](http://www.w3.org/2000/01/rdf-schema#label) "cytosolic region" -- [folliculostellate cell](http://purl.obolibrary.org/obo/CL_0000642) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [adenohypophysis](http://purl.obolibrary.org/obo/UBERON_0002196) +- [cytosolic region](http://purl.obolibrary.org/obo/GO_0099522) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0099522" +- [cytosolic region](http://purl.obolibrary.org/obo/GO_0099522) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "cellular_component" -### folliculostellate cell of pars distalis of adenohypophysis `http://purl.obolibrary.org/obo/CL_0002177` -#### Removed -- [folliculostellate cell of pars distalis of adenohypophysis](http://purl.obolibrary.org/obo/CL_0002177) SubClassOf [pituitary gland cell](http://purl.obolibrary.org/obo/CL_2000004) +- [cytosolic region](http://purl.obolibrary.org/obo/GO_0099522) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate) +- Class: [cytosolic region](http://purl.obolibrary.org/obo/GO_0099522) +- [cytosolic region](http://purl.obolibrary.org/obo/GO_0099522) EquivalentTo [cytosol](http://purl.obolibrary.org/obo/GO_0005829) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [cytosol](http://purl.obolibrary.org/obo/GO_0005829)) -### forebrain-midbrain boundary `http://purl.obolibrary.org/obo/UBERON_0005075` -#### Removed -- [forebrain-midbrain boundary](http://purl.obolibrary.org/obo/UBERON_0005075) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [cytosolic region](http://purl.obolibrary.org/obo/GO_0099522) SubClassOf [cytosol](http://purl.obolibrary.org/obo/GO_0005829) +- [cytosolic region](http://purl.obolibrary.org/obo/GO_0099522) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [cytosol](http://purl.obolibrary.org/obo/GO_0005829) -### forkhead box protein N1 `http://purl.obolibrary.org/obo/PR_000007636` +### cytosolic ribosome `http://purl.obolibrary.org/obo/GO_0022626` #### Added -- [forkhead box protein N1](http://purl.obolibrary.org/obo/PR_000007636) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [forkhead box protein N1 (human)](http://purl.obolibrary.org/obo/PR_O15353) +- [cytosolic ribosome](http://purl.obolibrary.org/obo/GO_0022626) [label](http://www.w3.org/2000/01/rdf-schema#label) "cytosolic ribosome" +- [cytosolic ribosome](http://purl.obolibrary.org/obo/GO_0022626) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "cellular_component" -### forkhead box protein P3 `http://purl.obolibrary.org/obo/PR_000001350` +- [cytosolic ribosome](http://purl.obolibrary.org/obo/GO_0022626) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "70S ribosome" -#### Added -- [forkhead box protein P3](http://purl.obolibrary.org/obo/PR_000001350) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [forkhead box protein P3 (human)](http://purl.obolibrary.org/obo/PR_Q9BZS1) +- [cytosolic ribosome](http://purl.obolibrary.org/obo/GO_0022626) [has_alternative_id](http://www.geneontology.org/formats/oboInOwl#hasAlternativeId) "GO:0030871" +- [cytosolic ribosome](http://purl.obolibrary.org/obo/GO_0022626) [has_alternative_id](http://www.geneontology.org/formats/oboInOwl#hasAlternativeId) "GO:0009281" -### fourth ventricle `http://purl.obolibrary.org/obo/UBERON_0002422` -#### Removed -- [fourth ventricle](http://purl.obolibrary.org/obo/UBERON_0002422) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [cytosolic ribosome](http://purl.obolibrary.org/obo/GO_0022626) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "80S ribosome" +- [cytosolic ribosome](http://purl.obolibrary.org/obo/GO_0022626) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0022626" +- [cytosolic ribosome](http://purl.obolibrary.org/obo/GO_0022626) [has_alternative_id](http://www.geneontology.org/formats/oboInOwl#hasAlternativeId) "GO:0005830" -### fovea centralis `http://purl.obolibrary.org/obo/UBERON_0001786` -#### Removed -- [fovea centralis](http://purl.obolibrary.org/obo/UBERON_0001786) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [cytosolic ribosome](http://purl.obolibrary.org/obo/GO_0022626) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A ribosome located in the cytosol." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:mtg_sensu" +- Class: [cytosolic ribosome](http://purl.obolibrary.org/obo/GO_0022626) +- [cytosolic ribosome](http://purl.obolibrary.org/obo/GO_0022626) EquivalentTo [ribosome](http://purl.obolibrary.org/obo/GO_0005840) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [cytosol](http://purl.obolibrary.org/obo/GO_0005829)) -### fraction A pre-pro B cell `http://purl.obolibrary.org/obo/CL_0002045` -#### Removed -- [fraction A pre-pro B cell](http://purl.obolibrary.org/obo/CL_0002045) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [cytosolic ribosome](http://purl.obolibrary.org/obo/GO_0022626) SubClassOf [only in taxon](http://purl.obolibrary.org/obo/RO_0002160) some [cellular organisms](http://purl.obolibrary.org/obo/NCBITaxon_131567) +- [cytosolic ribosome](http://purl.obolibrary.org/obo/GO_0022626) SubClassOf [ribosome](http://purl.obolibrary.org/obo/GO_0005840) +- [cytosolic ribosome](http://purl.obolibrary.org/obo/GO_0022626) SubClassOf [in taxon](http://purl.obolibrary.org/obo/RO_0002162) only [cellular organisms](http://purl.obolibrary.org/obo/NCBITaxon_131567) -### frontonasal process epithelium `http://purl.obolibrary.org/obo/UBERON_0014702` -#### Removed -- [frontonasal process epithelium](http://purl.obolibrary.org/obo/UBERON_0014702) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [cytosolic ribosome](http://purl.obolibrary.org/obo/GO_0022626) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [cytosol](http://purl.obolibrary.org/obo/GO_0005829) +### cytosolic transport `http://purl.obolibrary.org/obo/GO_0016482` -### fundus of stomach `http://purl.obolibrary.org/obo/UBERON_0001160` -#### Removed -- [fundus of stomach](http://purl.obolibrary.org/obo/UBERON_0001160) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +#### Added +- [cytosolic transport](http://purl.obolibrary.org/obo/GO_0016482) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0016482" +- [cytosolic transport](http://purl.obolibrary.org/obo/GO_0016482) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" +- [cytosolic transport](http://purl.obolibrary.org/obo/GO_0016482) [label](http://www.w3.org/2000/01/rdf-schema#label) "cytosolic transport" -### fundus of urinary bladder `http://purl.obolibrary.org/obo/UBERON_0006082` -#### Removed -- [fundus of urinary bladder](http://purl.obolibrary.org/obo/UBERON_0006082) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [cytosolic transport](http://purl.obolibrary.org/obo/GO_0016482) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The directed movement of substances or organelles within the cytosol." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:ai" +- Class: [cytosolic transport](http://purl.obolibrary.org/obo/GO_0016482) +- [cytosolic transport](http://purl.obolibrary.org/obo/GO_0016482) EquivalentTo [transport](http://purl.obolibrary.org/obo/GO_0006810) and ([occurs in](http://purl.obolibrary.org/obo/BFO_0000066) some [cytosol](http://purl.obolibrary.org/obo/GO_0005829)) -### future coelemic cavity lumen `http://purl.obolibrary.org/obo/UBERON_0003886` -#### Removed -- [future coelemic cavity lumen](http://purl.obolibrary.org/obo/UBERON_0003886) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [cytosolic transport](http://purl.obolibrary.org/obo/GO_0016482) SubClassOf [occurs in](http://purl.obolibrary.org/obo/BFO_0000066) some [cytosol](http://purl.obolibrary.org/obo/GO_0005829) +- [cytosolic transport](http://purl.obolibrary.org/obo/GO_0016482) SubClassOf [intracellular transport](http://purl.obolibrary.org/obo/GO_0046907) -### future dermis `http://purl.obolibrary.org/obo/UBERON_0010083` +### data about an ontology part `http://purl.obolibrary.org/obo/IAO_0000102` #### Removed -- [future dermis](http://purl.obolibrary.org/obo/UBERON_0010083) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) - +- [data about an ontology part](http://purl.obolibrary.org/obo/IAO_0000102) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "data about an ontology part"@en +- [data about an ontology part](http://purl.obolibrary.org/obo/IAO_0000102) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Data about an ontology part is a data item about a part of an ontology, for example a term"@en -### future diaphragm `http://purl.obolibrary.org/obo/UBERON_0010084` -#### Removed -- [future diaphragm](http://purl.obolibrary.org/obo/UBERON_0010084) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [data about an ontology part](http://purl.obolibrary.org/obo/IAO_0000102) [label](http://www.w3.org/2000/01/rdf-schema#label) "data about an ontology part"@en +- [data about an ontology part](http://purl.obolibrary.org/obo/IAO_0000102) [IAO_0000117](http://purl.obolibrary.org/obo/IAO_0000117) "Person:Alan Ruttenberg"@en +- Class: [data about an ontology part](http://purl.obolibrary.org/obo/IAO_0000102) -### future facial nucleus `http://purl.obolibrary.org/obo/UBERON_0010123` -#### Removed -- [future facial nucleus](http://purl.obolibrary.org/obo/UBERON_0010123) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [data about an ontology part](http://purl.obolibrary.org/obo/IAO_0000102) SubClassOf [data item](http://purl.obolibrary.org/obo/IAO_0000027) -### future glans `http://purl.obolibrary.org/obo/UBERON_0013238` +### data item `http://purl.obolibrary.org/obo/IAO_0000027` #### Removed -- [future glans](http://purl.obolibrary.org/obo/UBERON_0013238) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [data item](http://purl.obolibrary.org/obo/IAO_0000027) [IAO_0000114](http://purl.obolibrary.org/obo/IAO_0000114) [pending final vetting](http://purl.obolibrary.org/obo/IAO_0000125) +- [data item](http://purl.obolibrary.org/obo/IAO_0000027) [IAO_0000117](http://purl.obolibrary.org/obo/IAO_0000117) "PERSON: Alan Ruttenberg"@en +- [data item](http://purl.obolibrary.org/obo/IAO_0000027) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "data item"@en -### future lower lip `http://purl.obolibrary.org/obo/UBERON_0011596` -#### Removed -- [future lower lip](http://purl.obolibrary.org/obo/UBERON_0011596) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [data item](http://purl.obolibrary.org/obo/IAO_0000027) [IAO_0000118](http://purl.obolibrary.org/obo/IAO_0000118) "data"@en +- [data item](http://purl.obolibrary.org/obo/IAO_0000027) [editor note](http://purl.obolibrary.org/obo/IAO_0000116) "2014-03-31: See discussion at http://odontomachus.wordpress.com/2014/03/30/aboutness-objects-propositions/" +- [data item](http://purl.obolibrary.org/obo/IAO_0000027) [IAO_0000117](http://purl.obolibrary.org/obo/IAO_0000117) "PERSON: Jonathan Rees"@en -### future mouth `http://purl.obolibrary.org/obo/UBERON_0035804` -#### Removed -- [future mouth](http://purl.obolibrary.org/obo/UBERON_0035804) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [data item](http://purl.obolibrary.org/obo/IAO_0000027) [IAO_0000112](http://purl.obolibrary.org/obo/IAO_0000112) "Data items include counts of things, analyte concentrations, and statistical summaries."@en +- [data item](http://purl.obolibrary.org/obo/IAO_0000027) [label](http://www.w3.org/2000/01/rdf-schema#label) "data item"@en +- [data item](http://purl.obolibrary.org/obo/IAO_0000027) [editor note](http://purl.obolibrary.org/obo/IAO_0000116) "2/2/2009 Alan and Bjoern discussing FACS run output data. This is a data item because it is about the cell population. Each element records an event and is typically further composed a set of measurment data items that record the fluorescent intensity stimulated by one of the lasers."@en -### future superior salivatory nucleus `http://purl.obolibrary.org/obo/UBERON_0010125` -#### Removed -- [future superior salivatory nucleus](http://purl.obolibrary.org/obo/UBERON_0010125) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [data item](http://purl.obolibrary.org/obo/IAO_0000027) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "An information content entity that is intended to be a truthful statement about something (modulo, e.g., measurement precision or other systematic errors) and is constructed/acquired by a method which reliably tends to produce (approximately) truthful statements."@en +- [data item](http://purl.obolibrary.org/obo/IAO_0000027) [editor note](http://purl.obolibrary.org/obo/IAO_0000116) "JAR: datum -- well, this will be very tricky to define, but maybe some +information-like stuff that might be put into a computer and that is +meant, by someone, to denote and/or to be interpreted by some +process... I would include lists, tables, sentences... I think I might +defer to Barry, or to Brian Cantwell Smith +JAR: A data item is an approximately justified approximately true approximate belief"@en -### future upper lip `http://purl.obolibrary.org/obo/UBERON_0011592` -#### Removed -- [future upper lip](http://purl.obolibrary.org/obo/UBERON_0011592) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [data item](http://purl.obolibrary.org/obo/IAO_0000027) [editor note](http://purl.obolibrary.org/obo/IAO_0000116) "2009-03-16: data item deliberatly ambiguous: we merged data set and datum to be one entity, not knowing how to define singular versus plural. So data item is more general than datum."@en +- [data item](http://purl.obolibrary.org/obo/IAO_0000027) [editor note](http://purl.obolibrary.org/obo/IAO_0000116) "2009-03-16: removed datum as alternative term as datum specifically refers to singular form, and is thus not an exact synonym."@en +- [data item](http://purl.obolibrary.org/obo/IAO_0000027) [IAO_0000117](http://purl.obolibrary.org/obo/IAO_0000117) "PERSON: Chris Stoeckert"@en -### galectin-1 `http://purl.obolibrary.org/obo/PR_000009766` +- Class: [data item](http://purl.obolibrary.org/obo/IAO_0000027) -#### Added -- [galectin-1](http://purl.obolibrary.org/obo/PR_000009766) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [galectin-1 (human)](http://purl.obolibrary.org/obo/PR_P09382) +- [data item](http://purl.obolibrary.org/obo/IAO_0000027) SubClassOf [information content entity](http://purl.obolibrary.org/obo/IAO_0000030) -### gamma-delta T cell `http://purl.obolibrary.org/obo/CL_0000798` -#### Removed -- [gamma-delta T cell](http://purl.obolibrary.org/obo/CL_0000798) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) - - - -### gamma-synuclein `http://purl.obolibrary.org/obo/PR_000015325` -#### Added -- [gamma-synuclein](http://purl.obolibrary.org/obo/PR_000015325) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [gamma-synuclein (human)](http://purl.obolibrary.org/obo/PR_O76070) +### defined class `http://purl.obolibrary.org/obo/IAO_0000420` +#### Removed +- [defined class](http://purl.obolibrary.org/obo/IAO_0000420) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "defined class"@en +- [defined class](http://purl.obolibrary.org/obo/IAO_0000420) [label](http://www.w3.org/2000/01/rdf-schema#label) "defined class"@en -### ganglion `http://purl.obolibrary.org/obo/UBERON_0000045` -#### Removed -- [ganglion](http://purl.obolibrary.org/obo/UBERON_0000045) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [defined class](http://purl.obolibrary.org/obo/IAO_0000420) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A defined class is a class that is defined by a set of logically necessary and sufficient conditions but is not a universal"@en +- [defined class](http://purl.obolibrary.org/obo/IAO_0000420) [IAO_0000117](http://purl.obolibrary.org/obo/IAO_0000117) "Alan Ruttenberg"@en +- [defined class](http://purl.obolibrary.org/obo/IAO_0000420) [editor note](http://purl.obolibrary.org/obo/IAO_0000116) ""definitions", in some readings, always are given by necessary and sufficient conditions. So one must be careful (and this is difficult sometimes) to distinguish between defined classes and universal."@en -### ganglion mother cell `http://purl.obolibrary.org/obo/CL_0000469` -#### Removed -- [ganglion mother cell](http://purl.obolibrary.org/obo/CL_0000469) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- Individual: [defined class](http://purl.obolibrary.org/obo/IAO_0000420) -### ganglionic layer of retina `http://purl.obolibrary.org/obo/UBERON_0001792` +### definition `http://purl.obolibrary.org/obo/IAO_0000115` #### Removed -- [ganglionic layer of retina](http://purl.obolibrary.org/obo/UBERON_0001792) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [definition](http://purl.obolibrary.org/obo/IAO_0000115) [IAO_0000114](http://purl.obolibrary.org/obo/IAO_0000114) [ready for release](http://purl.obolibrary.org/obo/IAO_0000122) +- [definition](http://purl.obolibrary.org/obo/IAO_0000115) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "definition"@en +- [definition](http://purl.obolibrary.org/obo/IAO_0000115) [isDefinedBy](http://www.w3.org/2000/01/rdf-schema#isDefinedBy) [iao.owl](http://purl.obolibrary.org/obo/iao.owl) -### gastrula `http://purl.obolibrary.org/obo/UBERON_0004734` -#### Removed -- [gastrula](http://purl.obolibrary.org/obo/UBERON_0004734) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [definition](http://purl.obolibrary.org/obo/IAO_0000115) [label](http://www.w3.org/2000/01/rdf-schema#label) "definition"@en +- [definition](http://purl.obolibrary.org/obo/IAO_0000115) [editor note](http://purl.obolibrary.org/obo/IAO_0000116) "2012-04-05: +Barry Smith +The official OBI definition, explaining the meaning of a class or property: 'Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions' is terrible. -### generically dependent continuant `http://purl.obolibrary.org/obo/BFO_0000031` -#### Removed -- [generically dependent continuant](http://purl.obolibrary.org/obo/BFO_0000031) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A continuant that is dependent on one or other independent continuant bearers. For every instance of A requires some instance of (an independent continuant type) B but which instance of B serves can change from time to time."@en +Can you fix to something like: -#### Added -- [generically dependent continuant](http://purl.obolibrary.org/obo/BFO_0000031) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "b is a generically dependent continuant = Def. b is a continuant that g-depends_on one or more other entities. (axiom label in BFO2 Reference: [074-001])"@en +A statement of necessary and sufficient conditions explaining the meaning of an expression referring to a class or property. -- [generically dependent continuant](http://purl.obolibrary.org/obo/BFO_0000031) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "A continuant that is dependent on one or other independent continuant bearers. For every instance of A requires some instance of (an independent continuant type) B but which instance of B serves can change from time to time."@en +Alan Ruttenberg +Your proposed definition is a reasonable candidate, except that it is very common that necessary and sufficient conditions are not given. Mostly they are necessary, occasionally they are necessary and sufficient or just sufficient. Often they use terms that are not themselves defined and so they effectively can't be evaluated by those criteria. -### genitourinary system `http://purl.obolibrary.org/obo/UBERON_0004122` -#### Removed -- [genitourinary system](http://purl.obolibrary.org/obo/UBERON_0004122) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +On the specifics of the proposed definition: +We don't have definitions of 'meaning' or 'expression' or 'property'. For 'reference' in the intended sense I think we use the term 'denotation'. For 'expression', I think we you mean symbol, or identifier. For 'meaning' it differs for class and property. For class we want documentation that let's the intended reader determine whether an entity is instance of the class, or not. For property we want documentation that let's the intended reader determine, given a pair of potential relata, whether the assertion that the relation holds is true. The 'intended reader' part suggests that we also specify who, we expect, would be able to understand the definition, and also generalizes over human and computer reader to include textual and logical definition. +Personally, I am more comfortable weakening definition to documentation, with instructions as to what is desirable. -### germ layer / neural crest `http://purl.obolibrary.org/obo/UBERON_0010316` -#### Removed -- [germ layer / neural crest](http://purl.obolibrary.org/obo/UBERON_0010316) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +We also have the outstanding issue of how to aim different definitions to different audiences. A clinical audience reading chebi wants a different sort of definition documentation/definition from a chemistry trained audience, and similarly there is a need for a definition that is adequate for an ontologist to work with. "@en +- [definition](http://purl.obolibrary.org/obo/IAO_0000115) [IAO_0000119](http://purl.obolibrary.org/obo/IAO_0000119) "GROUP:OBI:<http://purl.obolibrary.org/obo/obi>"@en +- [definition](http://purl.obolibrary.org/obo/IAO_0000115) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The official definition, explaining the meaning of a class or property. Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions."@en -### girdle skeleton `http://purl.obolibrary.org/obo/UBERON_0010719` -#### Removed -- [girdle skeleton](http://purl.obolibrary.org/obo/UBERON_0010719) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000) +- [definition](http://purl.obolibrary.org/obo/IAO_0000115) [IAO_0000117](http://purl.obolibrary.org/obo/IAO_0000117) "PERSON:Daniel Schober"@en -### glans `http://purl.obolibrary.org/obo/UBERON_0035651` +### denotator type `http://purl.obolibrary.org/obo/IAO_0000409` #### Removed -- [glans](http://purl.obolibrary.org/obo/UBERON_0035651) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) - +- [denotator type](http://purl.obolibrary.org/obo/IAO_0000409) [IAO_0000119](http://purl.obolibrary.org/obo/IAO_0000119) "Barry Smith, Werner Ceusters"@en +- [denotator type](http://purl.obolibrary.org/obo/IAO_0000409) [IAO_0000117](http://purl.obolibrary.org/obo/IAO_0000117) "Alan Ruttenberg"@en -### glial blood brain barrier `http://purl.obolibrary.org/obo/UBERON_0000202` -#### Removed -- [glial blood brain barrier](http://purl.obolibrary.org/obo/UBERON_0000202) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [denotator type](http://purl.obolibrary.org/obo/IAO_0000409) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "denotator type"@en +- [denotator type](http://purl.obolibrary.org/obo/IAO_0000409) [label](http://www.w3.org/2000/01/rdf-schema#label) "denotator type"@en +- [denotator type](http://purl.obolibrary.org/obo/IAO_0000409) [IAO_0000112](http://purl.obolibrary.org/obo/IAO_0000112) "The Basic Formal Ontology ontology makes a distinction between Universals and defined classes, where the formal are "natural kinds" and the latter arbitrary collections of entities."@en -### glial fibrillary acidic protein `http://purl.obolibrary.org/obo/PR_000007939` +- [denotator type](http://purl.obolibrary.org/obo/IAO_0000409) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A denotator type indicates how a term should be interpreted from an ontological perspective."@en -#### Added -- [glial fibrillary acidic protein](http://purl.obolibrary.org/obo/PR_000007939) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [glial fibrillary acidic protein (human)](http://purl.obolibrary.org/obo/PR_P14136) +- Class: [denotator type](http://purl.obolibrary.org/obo/IAO_0000409) +- [denotator type](http://purl.obolibrary.org/obo/IAO_0000409) EquivalentTo {[universal](http://purl.obolibrary.org/obo/IAO_0000410) , [defined class](http://purl.obolibrary.org/obo/IAO_0000420) , [named class expression](http://purl.obolibrary.org/obo/IAO_0000421)} -### glioblast `http://purl.obolibrary.org/obo/CL_0000030` -#### Removed -- [glioblast](http://purl.obolibrary.org/obo/CL_0000030) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [denotator type](http://purl.obolibrary.org/obo/IAO_0000409) SubClassOf [data about an ontology part](http://purl.obolibrary.org/obo/IAO_0000102) -### glomeral mesenchyme `http://purl.obolibrary.org/obo/UBERON_0007128` -#### Removed -- [glomeral mesenchyme](http://purl.obolibrary.org/obo/UBERON_0007128) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +### dense core granule `http://purl.obolibrary.org/obo/GO_0031045` +#### Added +- [dense core granule](http://purl.obolibrary.org/obo/GO_0031045) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0031045" +- [dense core granule](http://purl.obolibrary.org/obo/GO_0031045) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "dense core vesicle" + - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [syngo_official_label](http://purl.obolibrary.org/obo/go#syngo_official_label) -### glomerular capsule `http://purl.obolibrary.org/obo/UBERON_0001230` -#### Removed -- [glomerular capsule](http://purl.obolibrary.org/obo/UBERON_0001230) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:kmv" +- [dense core granule](http://purl.obolibrary.org/obo/GO_0031045) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "cellular_component" +- [dense core granule](http://purl.obolibrary.org/obo/GO_0031045) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "NIF_Subcellular:sao772007592" -### glossopharyngeal nerve `http://purl.obolibrary.org/obo/UBERON_0001649` -#### Removed -- [glossopharyngeal nerve](http://purl.obolibrary.org/obo/UBERON_0001649) SubClassOf [neuron projection bundle](http://purl.obolibrary.org/obo/CARO_0001001) +- [dense core granule](http://purl.obolibrary.org/obo/GO_0031045) [label](http://www.w3.org/2000/01/rdf-schema#label) "dense core granule" +- [dense core granule](http://purl.obolibrary.org/obo/GO_0031045) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Electron-dense organelle with a granular internal matrix; contains proteins destined to be secreted." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "NIF_Subcellular:sao772007592" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:14690495" -### glutamate decarboxylase 1 `http://purl.obolibrary.org/obo/PR_000007785` +- Class: [dense core granule](http://purl.obolibrary.org/obo/GO_0031045) -#### Added -- [glutamate decarboxylase 1](http://purl.obolibrary.org/obo/PR_000007785) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [glutamate decarboxylase 1 (human)](http://purl.obolibrary.org/obo/PR_Q99259) +- [dense core granule](http://purl.obolibrary.org/obo/GO_0031045) SubClassOf [secretory granule](http://purl.obolibrary.org/obo/GO_0030141) -### glutamyl aminopeptidase `http://purl.obolibrary.org/obo/PR_000002039` +### dense core granule cytoskeletal transport `http://purl.obolibrary.org/obo/GO_0099519` #### Added -- [glutamyl aminopeptidase](http://purl.obolibrary.org/obo/PR_000002039) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [glutamyl aminopeptidase (human)](http://purl.obolibrary.org/obo/PR_Q07075) +- [dense core granule cytoskeletal transport](http://purl.obolibrary.org/obo/GO_0099519) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "dense core vesicle cytoskeletal trafficking" +- [dense core granule cytoskeletal transport](http://purl.obolibrary.org/obo/GO_0099519) [label](http://www.w3.org/2000/01/rdf-schema#label) "dense core granule cytoskeletal transport" -### glycophorin-A `http://purl.obolibrary.org/obo/PR_000001460` +- [dense core granule cytoskeletal transport](http://purl.obolibrary.org/obo/GO_0099519) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The directed movement of dense core granules along cytoskeletal fibers, such as microtubules or actin filaments." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:23358451" -#### Added -- [glycophorin-A](http://purl.obolibrary.org/obo/PR_000001460) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [glycophorin-A (human)](http://purl.obolibrary.org/obo/PR_P02724) + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:kmv" +- [dense core granule cytoskeletal transport](http://purl.obolibrary.org/obo/GO_0099519) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0099519" -### gonad primordium `http://purl.obolibrary.org/obo/UBERON_0005564` -#### Removed -- [gonad primordium](http://purl.obolibrary.org/obo/UBERON_0005564) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [dense core granule cytoskeletal transport](http://purl.obolibrary.org/obo/GO_0099519) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" +- Class: [dense core granule cytoskeletal transport](http://purl.obolibrary.org/obo/GO_0099519) +- [dense core granule cytoskeletal transport](http://purl.obolibrary.org/obo/GO_0099519) EquivalentTo [intracellular transport](http://purl.obolibrary.org/obo/GO_0046907) and ([occurs in](http://purl.obolibrary.org/obo/BFO_0000066) some [axon](http://purl.obolibrary.org/obo/GO_0030424)) and ([results in transport along](http://purl.obolibrary.org/obo/RO_0002341) some [polymeric cytoskeletal fiber](http://purl.obolibrary.org/obo/GO_0099513)) and ([has primary input](http://purl.obolibrary.org/obo/RO_0004009) some [dense core granule](http://purl.obolibrary.org/obo/GO_0031045)) -### gonadal ridge `http://purl.obolibrary.org/obo/UBERON_0005294` -#### Removed -- [gonadal ridge](http://purl.obolibrary.org/obo/UBERON_0005294) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [dense core granule cytoskeletal transport](http://purl.obolibrary.org/obo/GO_0099519) SubClassOf [vesicle cytoskeletal trafficking](http://purl.obolibrary.org/obo/GO_0099518) +- [dense core granule cytoskeletal transport](http://purl.obolibrary.org/obo/GO_0099519) SubClassOf [occurs in](http://purl.obolibrary.org/obo/BFO_0000066) some [axon](http://purl.obolibrary.org/obo/GO_0030424) +- [dense core granule cytoskeletal transport](http://purl.obolibrary.org/obo/GO_0099519) SubClassOf [dense core granule transport](http://purl.obolibrary.org/obo/GO_1901950) -### gonadal vein `http://purl.obolibrary.org/obo/UBERON_0003848` -#### Removed -- [gonadal vein](http://purl.obolibrary.org/obo/UBERON_0003848) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000) +### dense core granule localization `http://purl.obolibrary.org/obo/GO_0032253` +#### Added +- [dense core granule localization](http://purl.obolibrary.org/obo/GO_0032253) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process in which a dense core granule is transported to, and/or maintained in, a specific location within the cell." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:mah" -### granular layer of cerebellar cortex `http://purl.obolibrary.org/obo/UBERON_0002956` -#### Removed -- [granular layer of cerebellar cortex](http://purl.obolibrary.org/obo/UBERON_0002956) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [dense core granule localization](http://purl.obolibrary.org/obo/GO_0032253) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "dense core vesicle localization" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:kmv" +- [dense core granule localization](http://purl.obolibrary.org/obo/GO_0032253) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "dense core granule clustering" +- [dense core granule localization](http://purl.obolibrary.org/obo/GO_0032253) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "dense core granule localisation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:mah" -### granule cell precursor `http://purl.obolibrary.org/obo/CL_0002362` -#### Removed -- [granule cell precursor](http://purl.obolibrary.org/obo/CL_0002362) [label](http://www.w3.org/2000/01/rdf-schema#label) "granule cell precursor" +- [dense core granule localization](http://purl.obolibrary.org/obo/GO_0032253) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" -- [granule cell precursor](http://purl.obolibrary.org/obo/CL_0002362) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A cell located in the outermost proliferative zone of the external germinal layer that can differentiate into astroglial cells and granule cells. This cell type is glial fibrillary acidic protein-positive and NK1-positive." - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:tfm" +- [dense core granule localization](http://purl.obolibrary.org/obo/GO_0032253) [label](http://www.w3.org/2000/01/rdf-schema#label) "dense core granule localization" - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:14745007" +- [dense core granule localization](http://purl.obolibrary.org/obo/GO_0032253) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0032253" -#### Added -- [granule cell precursor](http://purl.obolibrary.org/obo/CL_0002362) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A cell located in the outermost proliferative zone of the external germinal layer that can differentiate into astroglial cells and granule cells. This cell type is glial fibrillary acidic protein-positive and HNK1-positive." - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:tfm" +- Class: [dense core granule localization](http://purl.obolibrary.org/obo/GO_0032253) - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:14745007" +- [dense core granule localization](http://purl.obolibrary.org/obo/GO_0032253) EquivalentTo [localization](http://purl.obolibrary.org/obo/GO_0051179) and ([has primary input](http://purl.obolibrary.org/obo/RO_0004009) some [dense core granule](http://purl.obolibrary.org/obo/GO_0031045)) -- [granule cell precursor](http://purl.obolibrary.org/obo/CL_0002362) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "GCP" - - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation) +- [dense core granule localization](http://purl.obolibrary.org/obo/GO_0032253) SubClassOf [secretory granule localization](http://purl.obolibrary.org/obo/GO_0032252) - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.3389/fncir.2020.611841" +- [dense core granule localization](http://purl.obolibrary.org/obo/GO_0032253) SubClassOf [has primary input](http://purl.obolibrary.org/obo/RO_0004009) some [dense core granule](http://purl.obolibrary.org/obo/GO_0031045) -- [granule cell precursor](http://purl.obolibrary.org/obo/CL_0002362) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "granule cell precursor" - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.3389/fncir.2020.611841" -- [granule cell precursor](http://purl.obolibrary.org/obo/CL_0002362) [label](http://www.w3.org/2000/01/rdf-schema#label) "cerebellar granule cell precursor" +### dense core granule maturation `http://purl.obolibrary.org/obo/GO_1990502` -- [granule cell precursor](http://purl.obolibrary.org/obo/CL_0002362) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "granule cell progenitor" - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.3389/fncir.2020.611841" +#### Added +- [dense core granule maturation](http://purl.obolibrary.org/obo/GO_1990502) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Steps required to transform a dense core granule generated at the trans-Golgi network into a fully formed and transmissible dense core granule. Dense core granule maturation proceeds through clathrin-mediated membrane remodeling events and is essential for efficient processing of cargo within dense core granules as well as for removing factors that might otherwise interfere with dense core granule trafficking and exocytosis." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:22654674" -- [granule cell precursor](http://purl.obolibrary.org/obo/CL_0002362) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [upper rhombic lip](http://purl.obolibrary.org/obo/UBERON_0009841) + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:kmv" -- [granule cell precursor](http://purl.obolibrary.org/obo/CL_0002362) SubClassOf [neural cell](http://purl.obolibrary.org/obo/CL_0002319) +- [dense core granule maturation](http://purl.obolibrary.org/obo/GO_1990502) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "kmv" +- [dense core granule maturation](http://purl.obolibrary.org/obo/GO_1990502) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:1990502" -### granulocyte `http://purl.obolibrary.org/obo/CL_0000094` -#### Removed -- [granulocyte](http://purl.obolibrary.org/obo/CL_0000094) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [dense core granule maturation](http://purl.obolibrary.org/obo/GO_1990502) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2014-09-30T20:35:11Z" +- [dense core granule maturation](http://purl.obolibrary.org/obo/GO_1990502) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "dense core vesicle maturation" +- [dense core granule maturation](http://purl.obolibrary.org/obo/GO_1990502) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" -### granulocyte monocyte progenitor cell `http://purl.obolibrary.org/obo/CL_0000557` -#### Removed -- [granulocyte monocyte progenitor cell](http://purl.obolibrary.org/obo/CL_0000557) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [dense core granule maturation](http://purl.obolibrary.org/obo/GO_1990502) [label](http://www.w3.org/2000/01/rdf-schema#label) "dense core granule maturation" +- Class: [dense core granule maturation](http://purl.obolibrary.org/obo/GO_1990502) +- [dense core granule maturation](http://purl.obolibrary.org/obo/GO_1990502) EquivalentTo [developmental maturation](http://purl.obolibrary.org/obo/GO_0021700) and ([results in maturation of](http://purl.obolibrary.org/obo/RO_0002299) some [dense core granule](http://purl.obolibrary.org/obo/GO_0031045)) -### granulosa cell layer `http://purl.obolibrary.org/obo/UBERON_0005170` -#### Removed -- [granulosa cell layer](http://purl.obolibrary.org/obo/UBERON_0005170) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [dense core granule maturation](http://purl.obolibrary.org/obo/GO_1990502) SubClassOf [results in maturation of](http://purl.obolibrary.org/obo/RO_0002299) some [dense core granule](http://purl.obolibrary.org/obo/GO_0031045) +- [dense core granule maturation](http://purl.obolibrary.org/obo/GO_1990502) SubClassOf [secretory granule maturation](http://purl.obolibrary.org/obo/GO_0061792) -### granzyme B `http://purl.obolibrary.org/obo/PR_000003499` +### dense core granule membrane `http://purl.obolibrary.org/obo/GO_0032127` #### Added -- [granzyme B](http://purl.obolibrary.org/obo/PR_000003499) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [granzyme B (human)](http://purl.obolibrary.org/obo/PR_P10144) +- [dense core granule membrane](http://purl.obolibrary.org/obo/GO_0032127) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "cellular_component" +- [dense core granule membrane](http://purl.obolibrary.org/obo/GO_0032127) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0032127" -### group 2 innate lymphoid cell, human `http://purl.obolibrary.org/obo/CL_0001081` -#### Removed -- [group 2 innate lymphoid cell, human](http://purl.obolibrary.org/obo/CL_0001081) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [dense core granule membrane](http://purl.obolibrary.org/obo/GO_0032127) [label](http://www.w3.org/2000/01/rdf-schema#label) "dense core granule membrane" +- [dense core granule membrane](http://purl.obolibrary.org/obo/GO_0032127) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "dense core vesicle membrane" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:kmv" +- [dense core granule membrane](http://purl.obolibrary.org/obo/GO_0032127) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The lipid bilayer surrounding a dense core granule." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:mah" -### group 2 innate lymphoid cell, mouse `http://purl.obolibrary.org/obo/CL_0002089` -#### Removed -- [group 2 innate lymphoid cell, mouse](http://purl.obolibrary.org/obo/CL_0002089) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- Class: [dense core granule membrane](http://purl.obolibrary.org/obo/GO_0032127) +- [dense core granule membrane](http://purl.obolibrary.org/obo/GO_0032127) EquivalentTo [membrane](http://purl.obolibrary.org/obo/GO_0016020) and ([bounding layer of](http://purl.obolibrary.org/obo/RO_0002007) some [dense core granule](http://purl.obolibrary.org/obo/GO_0031045)) +- [dense core granule membrane](http://purl.obolibrary.org/obo/GO_0032127) SubClassOf [secretory granule membrane](http://purl.obolibrary.org/obo/GO_0030667) -### group 3 innate lymphoid cell, human `http://purl.obolibrary.org/obo/CL_0001078` -#### Removed -- [group 3 innate lymphoid cell, human](http://purl.obolibrary.org/obo/CL_0001078) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [dense core granule membrane](http://purl.obolibrary.org/obo/GO_0032127) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [dense core granule](http://purl.obolibrary.org/obo/GO_0031045) +- [dense core granule membrane](http://purl.obolibrary.org/obo/GO_0032127) SubClassOf [bounding layer of](http://purl.obolibrary.org/obo/RO_0002007) some [dense core granule](http://purl.obolibrary.org/obo/GO_0031045) -### gustatory papilla of tongue `http://purl.obolibrary.org/obo/UBERON_0014389` -#### Removed -- [gustatory papilla of tongue](http://purl.obolibrary.org/obo/UBERON_0014389) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +### dense core granule organization `http://purl.obolibrary.org/obo/GO_0061109` +#### Added +- [dense core granule organization](http://purl.obolibrary.org/obo/GO_0061109) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "dense core granule organisation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:mah" +- [dense core granule organization](http://purl.obolibrary.org/obo/GO_0061109) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0061109" -### hair follicle matrix region `http://purl.obolibrary.org/obo/UBERON_0006004` -#### Removed -- [hair follicle matrix region](http://purl.obolibrary.org/obo/UBERON_0006004) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [dense core granule organization](http://purl.obolibrary.org/obo/GO_0061109) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2010-05-01T09:34:37Z" +- [dense core granule organization](http://purl.obolibrary.org/obo/GO_0061109) [label](http://www.w3.org/2000/01/rdf-schema#label) "dense core granule organization" +- [dense core granule organization](http://purl.obolibrary.org/obo/GO_0061109) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "dph" -### hair inner root sheath `http://purl.obolibrary.org/obo/UBERON_0005941` -#### Removed -- [hair inner root sheath](http://purl.obolibrary.org/obo/UBERON_0005941) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [dense core granule organization](http://purl.obolibrary.org/obo/GO_0061109) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a dense core granule. A dense core granule is a secretory organelle found in endocrine cells." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dph" +- [dense core granule organization](http://purl.obolibrary.org/obo/GO_0061109) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" +- Class: [dense core granule organization](http://purl.obolibrary.org/obo/GO_0061109) -### has component activity `http://purl.obolibrary.org/obo/RO_0002017` -#### Removed -- [has component activity](http://purl.obolibrary.org/obo/RO_0002017) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "dos" +- [dense core granule organization](http://purl.obolibrary.org/obo/GO_0061109) EquivalentTo [cellular component organization](http://purl.obolibrary.org/obo/GO_0016043) and ([results in organization of](http://purl.obolibrary.org/obo/RO_0002592) some [dense core granule](http://purl.obolibrary.org/obo/GO_0031045)) -#### Added -- [has component activity](http://purl.obolibrary.org/obo/RO_0002017) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) [0000-0002-7073-9172](https://orcid.org/0000-0002-7073-9172) +- [dense core granule organization](http://purl.obolibrary.org/obo/GO_0061109) SubClassOf [results in organization of](http://purl.obolibrary.org/obo/RO_0002592) some [dense core granule](http://purl.obolibrary.org/obo/GO_0031045) +- [dense core granule organization](http://purl.obolibrary.org/obo/GO_0061109) SubClassOf [secretory granule organization](http://purl.obolibrary.org/obo/GO_0033363) -### has component process `http://purl.obolibrary.org/obo/RO_0002018` -#### Removed -- [has component process](http://purl.obolibrary.org/obo/RO_0002018) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "dos" -#### Added -- [has component process](http://purl.obolibrary.org/obo/RO_0002018) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) [0000-0002-7073-9172](https://orcid.org/0000-0002-7073-9172) +### dense core granule transport `http://purl.obolibrary.org/obo/GO_1901950` +#### Added +- [dense core granule transport](http://purl.obolibrary.org/obo/GO_1901950) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The directed movement a dense core granule within a cell." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:23358451" -### has developmental contribution from `http://purl.obolibrary.org/obo/RO_0002254` -#### Removed -- [has developmental contribution from](http://purl.obolibrary.org/obo/RO_0002254) Domain [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" -- [has developmental contribution from](http://purl.obolibrary.org/obo/RO_0002254) Range [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:kmv" -#### Added -- [has developmental contribution from](http://purl.obolibrary.org/obo/RO_0002254) Domain [anatomical entity](http://purl.obolibrary.org/obo/UBERON_0001062) +- [dense core granule transport](http://purl.obolibrary.org/obo/GO_1901950) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" -- [has developmental contribution from](http://purl.obolibrary.org/obo/RO_0002254) Range [anatomical entity](http://purl.obolibrary.org/obo/UBERON_0001062) +- [dense core granule transport](http://purl.obolibrary.org/obo/GO_1901950) [label](http://www.w3.org/2000/01/rdf-schema#label) "dense core granule transport" +- [dense core granule transport](http://purl.obolibrary.org/obo/GO_1901950) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:1901950" -### has developmental potential involving `http://purl.obolibrary.org/obo/RO_0002384` -#### Removed -- [has developmental potential involving](http://purl.obolibrary.org/obo/RO_0002384) Domain [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [dense core granule transport](http://purl.obolibrary.org/obo/GO_1901950) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2013-02-19T13:00:52Z" -- [has developmental potential involving](http://purl.obolibrary.org/obo/RO_0002384) Range [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [dense core granule transport](http://purl.obolibrary.org/obo/GO_1901950) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "goslim_synapse" -#### Added -- [has developmental potential involving](http://purl.obolibrary.org/obo/RO_0002384) Domain [anatomical entity](http://purl.obolibrary.org/obo/UBERON_0001062) +- [dense core granule transport](http://purl.obolibrary.org/obo/GO_1901950) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "dense core vesicle transport" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" -- [has developmental potential involving](http://purl.obolibrary.org/obo/RO_0002384) Range [anatomical entity](http://purl.obolibrary.org/obo/UBERON_0001062) +- [dense core granule transport](http://purl.obolibrary.org/obo/GO_1901950) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "pr" +- Class: [dense core granule transport](http://purl.obolibrary.org/obo/GO_1901950) -### has effector activity `http://purl.obolibrary.org/obo/RO_0002025` -#### Removed -- [has effector activity](http://purl.obolibrary.org/obo/RO_0002025) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A 'has effector activity' B if A and B are GO molecular functions (GO_0003674), A 'has component activity' B and B is the effector (output function) of B. Each compound function has only one effector activity." - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dos" +- [dense core granule transport](http://purl.obolibrary.org/obo/GO_1901950) EquivalentTo [transport](http://purl.obolibrary.org/obo/GO_0006810) and ([occurs in](http://purl.obolibrary.org/obo/BFO_0000066) some [cytosol](http://purl.obolibrary.org/obo/GO_0005829)) and ([has primary input](http://purl.obolibrary.org/obo/RO_0004009) some [dense core granule](http://purl.obolibrary.org/obo/GO_0031045)) -- [has effector activity](http://purl.obolibrary.org/obo/RO_0002025) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "dos" +- [dense core granule transport](http://purl.obolibrary.org/obo/GO_1901950) SubClassOf [dense core granule localization](http://purl.obolibrary.org/obo/GO_0032253) -#### Added -- [has effector activity](http://purl.obolibrary.org/obo/RO_0002025) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) [0000-0002-7073-9172](https://orcid.org/0000-0002-7073-9172) +- [dense core granule transport](http://purl.obolibrary.org/obo/GO_1901950) SubClassOf [establishment of vesicle localization](http://purl.obolibrary.org/obo/GO_0051650) -- [has effector activity](http://purl.obolibrary.org/obo/RO_0002025) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A 'has effector activity' B if A and B are GO molecular functions (GO_0003674), A 'has component activity' B and B is the effector (output function) of B. Each compound function has only one effector activity." - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) [0000-0002-7073-9172](https://orcid.org/0000-0002-7073-9172) +- [dense core granule transport](http://purl.obolibrary.org/obo/GO_1901950) SubClassOf [cytosolic transport](http://purl.obolibrary.org/obo/GO_0016482) -### has fasciculating neuron projection `http://purl.obolibrary.org/obo/RO_0002132` +### dentate gyrus granule cell layer `http://purl.obolibrary.org/obo/UBERON_0005381` #### Removed -- [has fasciculating neuron projection](http://purl.obolibrary.org/obo/RO_0002132) Domain [neuron projection bundle](http://purl.obolibrary.org/obo/CARO_0001001) +- [dentate gyrus granule cell layer](http://purl.obolibrary.org/obo/UBERON_0005381) SubClassOf [composed primarily of](http://purl.obolibrary.org/obo/RO_0002473) some [granule cell](http://purl.obolibrary.org/obo/CL_0000120) #### Added -- [has fasciculating neuron projection](http://purl.obolibrary.org/obo/RO_0002132) Domain [neuron projection bundle](http://purl.obolibrary.org/obo/UBERON_0000122) +- [dentate gyrus granule cell layer](http://purl.obolibrary.org/obo/UBERON_0005381) SubClassOf [composed primarily of](http://purl.obolibrary.org/obo/RO_0002473) some [dentate gyrus granule cell](http://purl.obolibrary.org/obo/CL_2000089) -### has high plasma membrane amount `http://purl.obolibrary.org/obo/RO_0015015` +### dentate gyrus mossy fiber `http://purl.obolibrary.org/obo/GO_0044302` #### Removed -- [has high plasma membrane amount](http://purl.obolibrary.org/obo/RO_0015015) [contributor](http://purl.org/dc/terms/contributor) [0000-0003-1940-6740](http://orcid.org/0000-0003-1940-6740) +- [dentate gyrus mossy fiber](http://purl.obolibrary.org/obo/GO_0044302) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Distinctive, unmyelinated axons produced by granule cells." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:17765709" -- [has high plasma membrane amount](http://purl.obolibrary.org/obo/RO_0015015) [contributor](http://purl.org/dc/terms/contributor) [0000-0003-1617-8244](http://orcid.org/0000-0003-1617-8244) + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "NIF_Subcellular:nlx_subcell_20090601" -#### Added -- [has high plasma membrane amount](http://purl.obolibrary.org/obo/RO_0015015) [contributor](http://purl.org/dc/terms/contributor) [0000-0003-1940-6740](https://orcid.org/0000-0003-1940-6740) +- [dentate gyrus mossy fiber](http://purl.obolibrary.org/obo/GO_0044302) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "granule cell axon" -- [has high plasma membrane amount](http://purl.obolibrary.org/obo/RO_0015015) [contributor](http://purl.org/dc/terms/contributor) [0000-0003-1617-8244](https://orcid.org/0000-0003-1617-8244) +- [dentate gyrus mossy fiber](http://purl.obolibrary.org/obo/GO_0044302) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [granule cell](http://purl.obolibrary.org/obo/CL_0000120) +#### Added +- [dentate gyrus mossy fiber](http://purl.obolibrary.org/obo/GO_0044302) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "granule cell axon" -### has input `http://purl.obolibrary.org/obo/RO_0002233` +- [dentate gyrus mossy fiber](http://purl.obolibrary.org/obo/GO_0044302) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Distinctive, unmyelinated axons produced by dentate gyrus granule cells." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:17765709" -#### Added -- [has input](http://purl.obolibrary.org/obo/RO_0002233) [see also](http://www.w3.org/2000/01/rdf-schema#seeAlso) "https://wiki.geneontology.org/Has_input"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI) + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "NIF_Subcellular:nlx_subcell_20090601" +- [dentate gyrus mossy fiber](http://purl.obolibrary.org/obo/GO_0044302) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [dentate gyrus granule cell](http://purl.obolibrary.org/obo/CL_2000089) -### has low plasma membrane amount `http://purl.obolibrary.org/obo/RO_0015016` -#### Removed -- [has low plasma membrane amount](http://purl.obolibrary.org/obo/RO_0015016) [contributor](http://purl.org/dc/terms/contributor) [0000-0003-1617-8244](http://orcid.org/0000-0003-1617-8244) -- [has low plasma membrane amount](http://purl.obolibrary.org/obo/RO_0015016) [contributor](http://purl.org/dc/terms/contributor) [0000-0003-1940-6740](http://orcid.org/0000-0003-1940-6740) +### detection of hypoxia `http://purl.obolibrary.org/obo/GO_0070483` #### Added -- [has low plasma membrane amount](http://purl.obolibrary.org/obo/RO_0015016) [contributor](http://purl.org/dc/terms/contributor) [0000-0003-1617-8244](https://orcid.org/0000-0003-1617-8244) +- [detection of hypoxia](http://purl.obolibrary.org/obo/GO_0070483) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The series of events in which a stimulus indicating lowered oxygen tension is received by a cell and converted into a molecular signal. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:mah" -- [has low plasma membrane amount](http://purl.obolibrary.org/obo/RO_0015016) [contributor](http://purl.org/dc/terms/contributor) [0000-0003-1940-6740](https://orcid.org/0000-0003-1940-6740) + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:BHF" +- [detection of hypoxia](http://purl.obolibrary.org/obo/GO_0070483) [label](http://www.w3.org/2000/01/rdf-schema#label) "detection of hypoxia" -### has muscle insertion `http://purl.obolibrary.org/obo/RO_0002373` -#### Removed -- [has muscle insertion](http://purl.obolibrary.org/obo/RO_0002373) Domain [connected anatomical structure](http://purl.obolibrary.org/obo/CARO_0000003) - - [editor note](http://purl.obolibrary.org/obo/IAO_0000116) "We need to import uberon muscle into RO to use as a stricter domain constraint" +- [detection of hypoxia](http://purl.obolibrary.org/obo/GO_0070483) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" -#### Added -- [has muscle insertion](http://purl.obolibrary.org/obo/RO_0002373) Domain [anatomical structure](http://purl.obolibrary.org/obo/UBERON_0000061) - - [editor note](http://purl.obolibrary.org/obo/IAO_0000116) "We need to import uberon muscle into RO to use as a stricter domain constraint" +- [detection of hypoxia](http://purl.obolibrary.org/obo/GO_0070483) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "detection of reduced oxygen levels" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:vk" +- [detection of hypoxia](http://purl.obolibrary.org/obo/GO_0070483) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0070483" -### has muscle origin `http://purl.obolibrary.org/obo/RO_0002372` -#### Removed -- [has muscle origin](http://purl.obolibrary.org/obo/RO_0002372) Domain [connected anatomical structure](http://purl.obolibrary.org/obo/CARO_0000003) - - [comment](http://www.w3.org/2000/01/rdf-schema#comment) "We need to import uberon muscle to create a stricter domain constraint" +- Class: [detection of hypoxia](http://purl.obolibrary.org/obo/GO_0070483) -#### Added -- [has muscle origin](http://purl.obolibrary.org/obo/RO_0002372) Domain [anatomical structure](http://purl.obolibrary.org/obo/UBERON_0000061) - - [comment](http://www.w3.org/2000/01/rdf-schema#comment) "We need to import uberon muscle to create a stricter domain constraint" +- [detection of hypoxia](http://purl.obolibrary.org/obo/GO_0070483) SubClassOf [detection of oxygen](http://purl.obolibrary.org/obo/GO_0003032) +- [detection of hypoxia](http://purl.obolibrary.org/obo/GO_0070483) SubClassOf [response to hypoxia](http://purl.obolibrary.org/obo/GO_0001666) -### has negative regulatory component activity `http://purl.obolibrary.org/obo/RO_0002014` -#### Removed -- [has negative regulatory component activity](http://purl.obolibrary.org/obo/RO_0002014) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "dos" -#### Added -- [has negative regulatory component activity](http://purl.obolibrary.org/obo/RO_0002014) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) [0000-0002-7073-9172](https://orcid.org/0000-0002-7073-9172) +### detection of oxygen `http://purl.obolibrary.org/obo/GO_0003032` +#### Added +- [detection of oxygen](http://purl.obolibrary.org/obo/GO_0003032) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" -### has obsolescence reason `http://purl.obolibrary.org/obo/IAO_0000231` +- [detection of oxygen](http://purl.obolibrary.org/obo/GO_0003032) [label](http://www.w3.org/2000/01/rdf-schema#label) "detection of oxygen" -#### Added -- [has obsolescence reason](http://purl.obolibrary.org/obo/IAO_0000231) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "has obsolescence reason"@en +- [detection of oxygen](http://purl.obolibrary.org/obo/GO_0003032) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0003032" -- [has obsolescence reason](http://purl.obolibrary.org/obo/IAO_0000231) [label](http://www.w3.org/2000/01/rdf-schema#label) "has obsolescence reason"@en +- [detection of oxygen](http://purl.obolibrary.org/obo/GO_0003032) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The series of events in which an oxygen stimulus is received by a cell and converted into a molecular signal." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:mtg_cardio" -- [has obsolescence reason](http://purl.obolibrary.org/obo/IAO_0000231) [IAO_0000117](http://purl.obolibrary.org/obo/IAO_0000117) "PERSON:Alan Ruttenberg"@en +- Class: [detection of oxygen](http://purl.obolibrary.org/obo/GO_0003032) -- [has obsolescence reason](http://purl.obolibrary.org/obo/IAO_0000231) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Relates an annotation property to an obsolescence reason. The values of obsolescence reasons come from a list of predefined terms, instances of the class obsolescence reason specification."@en +- [detection of oxygen](http://purl.obolibrary.org/obo/GO_0003032) SubClassOf [detection of chemical stimulus](http://purl.obolibrary.org/obo/GO_0009593) -- [has obsolescence reason](http://purl.obolibrary.org/obo/IAO_0000231) [IAO_0000117](http://purl.obolibrary.org/obo/IAO_0000117) "PERSON:Melanie Courtot"@en +- [detection of oxygen](http://purl.obolibrary.org/obo/GO_0003032) SubClassOf [response to oxygen levels](http://purl.obolibrary.org/obo/GO_0070482) -### has output `http://purl.obolibrary.org/obo/RO_0002234` +### device utilizes material `http://purl.obolibrary.org/obo/RO_0017001` +#### Removed +- [device utilizes material](http://purl.obolibrary.org/obo/RO_0017001) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2021-11-08T12:00:00Z" #### Added -- [has output](http://purl.obolibrary.org/obo/RO_0002234) [see also](http://www.w3.org/2000/01/rdf-schema#seeAlso) "https://wiki.geneontology.org/Has_output"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI) +- [device utilizes material](http://purl.obolibrary.org/obo/RO_0017001) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2021-11-08T12:00:00Z"^^[dateTime](http://www.w3.org/2001/XMLSchema#dateTime) -### has plasma membrane part `http://purl.obolibrary.org/obo/RO_0002104` +### diffuse multistratified amacrine cell `http://purl.obolibrary.org/obo/CL_0004234` #### Removed -- [has plasma membrane part](http://purl.obolibrary.org/obo/RO_0002104) Domain [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [diffuse multistratified amacrine cell](http://purl.obolibrary.org/obo/CL_0004234) SubClassOf [retina horizontal cell](http://purl.obolibrary.org/obo/CL_0000745) -- [has plasma membrane part](http://purl.obolibrary.org/obo/RO_0002104) Range [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) -#### Added -- [has plasma membrane part](http://purl.obolibrary.org/obo/RO_0002104) Domain [material anatomical entity](http://purl.obolibrary.org/obo/UBERON_0000465) -- [has plasma membrane part](http://purl.obolibrary.org/obo/RO_0002104) Range [material anatomical entity](http://purl.obolibrary.org/obo/UBERON_0000465) +### early lymphoid progenitor `http://purl.obolibrary.org/obo/CL_0000936` +#### Removed +- [early lymphoid progenitor](http://purl.obolibrary.org/obo/CL_0000936) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "ELP" +- [early lymphoid progenitor](http://purl.obolibrary.org/obo/CL_0000936) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "GMLP" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:18371378" -### has positive regulatory component activity `http://purl.obolibrary.org/obo/RO_0002015` -#### Removed -- [has positive regulatory component activity](http://purl.obolibrary.org/obo/RO_0002015) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "dos" +- [early lymphoid progenitor](http://purl.obolibrary.org/obo/CL_0000936) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "LMPP" #### Added -- [has positive regulatory component activity](http://purl.obolibrary.org/obo/RO_0002015) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) [0000-0002-7073-9172](https://orcid.org/0000-0002-7073-9172) +- [early lymphoid progenitor](http://purl.obolibrary.org/obo/CL_0000936) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "ELP" + - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation) +- [early lymphoid progenitor](http://purl.obolibrary.org/obo/CL_0000936) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "GMLP" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:18371378" -### has primary input `http://purl.obolibrary.org/obo/RO_0004009` + - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation) + +- [early lymphoid progenitor](http://purl.obolibrary.org/obo/CL_0000936) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "LMPP" + - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation) + + +### editor note `http://purl.obolibrary.org/obo/IAO_0000116` #### Removed -- [has primary input](http://purl.obolibrary.org/obo/RO_0004009) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "p has primary input c if (a) p has input c and (b) the goal of process is to modify, consume, or transform c." - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dph" +- [editor note](http://purl.obolibrary.org/obo/IAO_0000116) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "editor note"@en - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:cjm" +- [editor note](http://purl.obolibrary.org/obo/IAO_0000116) [label](http://www.w3.org/2000/01/rdf-schema#label) "editor note"@en - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:kva" +- [editor note](http://purl.obolibrary.org/obo/IAO_0000116) [IAO_0000119](http://purl.obolibrary.org/obo/IAO_0000119) "GROUP:OBI:<http://purl.obofoundry.org/obo/obi>"@en - - [comment](http://www.w3.org/2000/01/rdf-schema#comment) "PMID:27812932" +- [editor note](http://purl.obolibrary.org/obo/IAO_0000116) [IAO_0000114](http://purl.obolibrary.org/obo/IAO_0000114) [ready for release](http://purl.obolibrary.org/obo/IAO_0000122) - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:pt" +- [editor note](http://purl.obolibrary.org/obo/IAO_0000116) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "An administrative note intended for its editor. It may not be included in the publication version of the ontology, so it should contain nothing necessary for end users to understand the ontology."@en -#### Added -- [has primary input](http://purl.obolibrary.org/obo/RO_0004009) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "p has primary input c if (a) p has input c and (b) the goal of process is to modify, consume, or transform c." - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dph" +- [editor note](http://purl.obolibrary.org/obo/IAO_0000116) [IAO_0000117](http://purl.obolibrary.org/obo/IAO_0000117) "PERSON:Daniel Schober"@en + +- [editor note](http://purl.obolibrary.org/obo/IAO_0000116) [isDefinedBy](http://www.w3.org/2000/01/rdf-schema#isDefinedBy) [iao.owl](http://purl.obolibrary.org/obo/iao.owl) - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) [0000-0002-6601-2165](https://orcid.org/0000-0002-6601-2165) - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:kva" - - [comment](http://www.w3.org/2000/01/rdf-schema#comment) "PMID:27812932" +### egg cell `http://purl.obolibrary.org/obo/CL_0000025` - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:pt" +#### Added +- [egg cell](http://purl.obolibrary.org/obo/CL_0000025) [depicted by](http://xmlns.com/foaf/0.1/depicted_by) "https://www.swissbiopics.org/api/image/Egg_cell.svg"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI) -### has primary output `http://purl.obolibrary.org/obo/RO_0004008` +### engulfment of target by autophagosome `http://purl.obolibrary.org/obo/GO_0061736` #### Removed -- [has primary output](http://purl.obolibrary.org/obo/RO_0004008) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "p has primary output c if (a) p has output c and (b) the goal of process is to modify, produce, or transform c." - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dph" +- [engulfment of target by autophagosome](http://purl.obolibrary.org/obo/GO_0061736) [label](http://www.w3.org/2000/01/rdf-schema#label) "engulfment of target by autophagosome" - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:cjm" +- [engulfment of target by autophagosome](http://purl.obolibrary.org/obo/GO_0061736) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:kva" +- [engulfment of target by autophagosome](http://purl.obolibrary.org/obo/GO_0061736) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2015-09-14T14:10:24Z" - - [comment](http://www.w3.org/2000/01/rdf-schema#comment) "PMID:27812932" +- [engulfment of target by autophagosome](http://purl.obolibrary.org/obo/GO_0061736) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "dph" - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:pt" +- [engulfment of target by autophagosome](http://purl.obolibrary.org/obo/GO_0061736) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0061736" -#### Added -- [has primary output](http://purl.obolibrary.org/obo/RO_0004008) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "p has primary output c if (a) p has output c and (b) the goal of process is to modify, produce, or transform c." +- [engulfment of target by autophagosome](http://purl.obolibrary.org/obo/GO_0061736) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The membrane invagination process by which an autophagosomal membrane surrounds an object that will be degraded by macroautophagy." - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dph" - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) [0000-0002-6601-2165](https://orcid.org/0000-0002-6601-2165) + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:autophagy" - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:kva" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:PARL" - - [comment](http://www.w3.org/2000/01/rdf-schema#comment) "PMID:27812932" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:pad" - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:pt" +- Class: [engulfment of target by autophagosome](http://purl.obolibrary.org/obo/GO_0061736) +- [engulfment of target by autophagosome](http://purl.obolibrary.org/obo/GO_0061736) EquivalentTo [membrane invagination](http://purl.obolibrary.org/obo/GO_0010324) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [autophagosome assembly](http://purl.obolibrary.org/obo/GO_0000045)) -### has regulatory component activity `http://purl.obolibrary.org/obo/RO_0002013` -#### Removed -- [has regulatory component activity](http://purl.obolibrary.org/obo/RO_0002013) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "dos" +- [engulfment of target by autophagosome](http://purl.obolibrary.org/obo/GO_0061736) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [autophagosome assembly](http://purl.obolibrary.org/obo/GO_0000045) + +- [engulfment of target by autophagosome](http://purl.obolibrary.org/obo/GO_0061736) SubClassOf [membrane invagination](http://purl.obolibrary.org/obo/GO_0010324) -#### Added -- [has regulatory component activity](http://purl.obolibrary.org/obo/RO_0002013) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) [0000-0002-7073-9172](https://orcid.org/0000-0002-7073-9172) -### has sensory dendrite in `http://purl.obolibrary.org/obo/RO_0013007` +### enucleate erythrocyte `http://purl.obolibrary.org/obo/CL_0000595` #### Removed -- [has sensory dendrite in](http://purl.obolibrary.org/obo/RO_0013007) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) [0000-0002-1373-1705](http://orcid.org/0000-0002-1373-1705) +- [enucleate erythrocyte](http://purl.obolibrary.org/obo/CL_0000595) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "RBC" #### Added -- [has sensory dendrite in](http://purl.obolibrary.org/obo/RO_0013007) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) [0000-0002-1373-1705](https://orcid.org/0000-0002-1373-1705) +- [enucleate erythrocyte](http://purl.obolibrary.org/obo/CL_0000595) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "RBC" + - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation) -### has skeleton `http://purl.obolibrary.org/obo/RO_0002551` +### eosinophil progenitor cell `http://purl.obolibrary.org/obo/CL_0000611` #### Removed -- [has skeleton](http://purl.obolibrary.org/obo/RO_0002551) Domain [connected anatomical structure](http://purl.obolibrary.org/obo/CARO_0000003) +- [eosinophil progenitor cell](http://purl.obolibrary.org/obo/CL_0000611) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "EoP" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMCID:PMC2212039" -- [has skeleton](http://purl.obolibrary.org/obo/RO_0002551) Range [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) - - [editor note](http://purl.obolibrary.org/obo/IAO_0000116) "This should be to a more restricted class, but not the Uberon class may be too restricted since it is a composition-based definition of skeleton rather than functional." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMCID:PMC2626675" + +- [eosinophil progenitor cell](http://purl.obolibrary.org/obo/CL_0000611) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "CFU-Eo" #### Added -- [has skeleton](http://purl.obolibrary.org/obo/RO_0002551) Domain [anatomical structure](http://purl.obolibrary.org/obo/UBERON_0000061) +- [eosinophil progenitor cell](http://purl.obolibrary.org/obo/CL_0000611) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "EoP" + - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation) -- [has skeleton](http://purl.obolibrary.org/obo/RO_0002551) Range [material anatomical entity](http://purl.obolibrary.org/obo/UBERON_0000465) - - [editor note](http://purl.obolibrary.org/obo/IAO_0000116) "This should be to a more restricted class, but not the Uberon class may be too restricted since it is a composition-based definition of skeleton rather than functional." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMCID:PMC2212039" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMCID:PMC2626675" -### has soma location `http://purl.obolibrary.org/obo/RO_0002100` -#### Removed -- [has soma location](http://purl.obolibrary.org/obo/RO_0002100) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Relation between a neuron and an anatomical structure that its soma is part of."@en +- [eosinophil progenitor cell](http://purl.obolibrary.org/obo/CL_0000611) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "CFU-Eo" + - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation) -- [has soma location](http://purl.obolibrary.org/obo/RO_0002100) Range [connected anatomical structure](http://purl.obolibrary.org/obo/CARO_0000003) -#### Added -- [has soma location](http://purl.obolibrary.org/obo/RO_0002100) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Relation between a neuron and a material anatomical entity that its soma is part of."@en +### epithelial cell `http://purl.obolibrary.org/obo/CL_0000066` -- [has soma location](http://purl.obolibrary.org/obo/RO_0002100) Range [material anatomical entity](http://purl.obolibrary.org/obo/UBERON_0000465) +#### Added +- [epithelial cell](http://purl.obolibrary.org/obo/CL_0000066) [depicted by](http://xmlns.com/foaf/0.1/depicted_by) "https://www.swissbiopics.org/api/image/Epithelial_cells.svg"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI) -### has synaptic IO in region `http://purl.obolibrary.org/obo/RO_0013001` +### epithelial cell morphogenesis `http://purl.obolibrary.org/obo/GO_0003382` #### Removed -- [has synaptic IO in region](http://purl.obolibrary.org/obo/RO_0013001) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) [0000-0002-1373-1705](http://orcid.org/0000-0002-1373-1705) +- [epithelial cell morphogenesis](http://purl.obolibrary.org/obo/GO_0003382) SubClassOf [cell morphogenesis involved in differentiation](http://purl.obolibrary.org/obo/GO_0000904) #### Added -- [has synaptic IO in region](http://purl.obolibrary.org/obo/RO_0013001) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) [0000-0002-1373-1705](https://orcid.org/0000-0002-1373-1705) +- [epithelial cell morphogenesis](http://purl.obolibrary.org/obo/GO_0003382) SubClassOf [cell morphogenesis](http://purl.obolibrary.org/obo/GO_0000902) -### head connective tissue `http://purl.obolibrary.org/obo/UBERON_0003566` -#### Removed -- [head connective tissue](http://purl.obolibrary.org/obo/UBERON_0003566) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +### epithelium of bronchiole `http://purl.obolibrary.org/obo/UBERON_0002051` + +#### Added +- [epithelium of bronchiole](http://purl.obolibrary.org/obo/UBERON_0002051) [contributor](http://purl.org/dc/terms/contributor) [0000-0001-6677-8489](https://orcid.org/0000-0001-6677-8489) +- [epithelium of bronchiole](http://purl.obolibrary.org/obo/UBERON_0002051) SubClassOf [has part](http://purl.obolibrary.org/obo/BFO_0000051) some [club cell](http://purl.obolibrary.org/obo/CL_0000158) +- [epithelium of bronchiole](http://purl.obolibrary.org/obo/UBERON_0002051) SubClassOf [has part](http://purl.obolibrary.org/obo/BFO_0000051) some [lung ciliated cell](http://purl.obolibrary.org/obo/CL_1000271) -### heart primordium `http://purl.obolibrary.org/obo/UBERON_0003084` -#### Removed -- [heart primordium](http://purl.obolibrary.org/obo/UBERON_0003084) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +### epithelium of lobar bronchus `http://purl.obolibrary.org/obo/UBERON_0002339` +#### Added +- [epithelium of lobar bronchus](http://purl.obolibrary.org/obo/UBERON_0002339) [contributor](http://purl.org/dc/terms/contributor) [0000-0001-6677-8489](https://orcid.org/0000-0001-6677-8489) -### hemangioblast `http://purl.obolibrary.org/obo/CL_0002418` -#### Removed -- [hemangioblast](http://purl.obolibrary.org/obo/CL_0002418) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [epithelium of lobar bronchus](http://purl.obolibrary.org/obo/UBERON_0002339) SubClassOf [has part](http://purl.obolibrary.org/obo/BFO_0000051) some [basal epithelial cell of tracheobronchial tree](http://purl.obolibrary.org/obo/CL_0002329) +- [epithelium of lobar bronchus](http://purl.obolibrary.org/obo/UBERON_0002339) SubClassOf [has part](http://purl.obolibrary.org/obo/BFO_0000051) some [pulmonary ionocyte](http://purl.obolibrary.org/obo/CL_0017000) +- [epithelium of lobar bronchus](http://purl.obolibrary.org/obo/UBERON_0002339) SubClassOf [has part](http://purl.obolibrary.org/obo/BFO_0000051) some [ciliated cell of the bronchus](http://purl.obolibrary.org/obo/CL_0002332) -### hematopoietic lineage restricted progenitor cell `http://purl.obolibrary.org/obo/CL_0002031` + +### epithelium of respiratory bronchiole `http://purl.obolibrary.org/obo/UBERON_0001955` #### Removed -- [hematopoietic lineage restricted progenitor cell](http://purl.obolibrary.org/obo/CL_0002031) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [epithelium of respiratory bronchiole](http://purl.obolibrary.org/obo/UBERON_0001955) SubClassOf [has part](http://purl.obolibrary.org/obo/BFO_0000051) some [club cell](http://purl.obolibrary.org/obo/CL_0000158) + - [source](http://www.geneontology.org/formats/oboInOwl#source) "FMA" -### hematopoietic multipotent progenitor cell `http://purl.obolibrary.org/obo/CL_0000837` -#### Removed -- [hematopoietic multipotent progenitor cell](http://purl.obolibrary.org/obo/CL_0000837) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +### epithelium of segmental bronchus `http://purl.obolibrary.org/obo/UBERON_0002341` +#### Added +- [epithelium of segmental bronchus](http://purl.obolibrary.org/obo/UBERON_0002341) [contributor](http://purl.org/dc/terms/contributor) [0000-0001-6677-8489](https://orcid.org/0000-0001-6677-8489) +- [epithelium of segmental bronchus](http://purl.obolibrary.org/obo/UBERON_0002341) SubClassOf [has part](http://purl.obolibrary.org/obo/BFO_0000051) some [club cell](http://purl.obolibrary.org/obo/CL_0000158) -### hematopoietic oligopotent progenitor cell `http://purl.obolibrary.org/obo/CL_0002032` -#### Removed -- [hematopoietic oligopotent progenitor cell](http://purl.obolibrary.org/obo/CL_0002032) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [epithelium of segmental bronchus](http://purl.obolibrary.org/obo/UBERON_0002341) SubClassOf [has part](http://purl.obolibrary.org/obo/BFO_0000051) some [lung neuroendocrine cell](http://purl.obolibrary.org/obo/CL_1000223) +- [epithelium of segmental bronchus](http://purl.obolibrary.org/obo/UBERON_0002341) SubClassOf [has part](http://purl.obolibrary.org/obo/BFO_0000051) some [brush cell of bronchus](http://purl.obolibrary.org/obo/CL_0002208) +- [epithelium of segmental bronchus](http://purl.obolibrary.org/obo/UBERON_0002341) SubClassOf [sensory epithelium](http://purl.obolibrary.org/obo/UBERON_0006934) -### hematopoietic system `http://purl.obolibrary.org/obo/UBERON_0002390` -#### Removed -- [hematopoietic system](http://purl.obolibrary.org/obo/UBERON_0002390) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [epithelium of segmental bronchus](http://purl.obolibrary.org/obo/UBERON_0002341) SubClassOf [has part](http://purl.obolibrary.org/obo/BFO_0000051) some [basal epithelial cell of tracheobronchial tree](http://purl.obolibrary.org/obo/CL_0002329) +- [epithelium of segmental bronchus](http://purl.obolibrary.org/obo/UBERON_0002341) SubClassOf [has part](http://purl.obolibrary.org/obo/BFO_0000051) some [lung goblet cell](http://purl.obolibrary.org/obo/CL_1000143) +- [epithelium of segmental bronchus](http://purl.obolibrary.org/obo/UBERON_0002341) SubClassOf [has part](http://purl.obolibrary.org/obo/BFO_0000051) some [pulmonary ionocyte](http://purl.obolibrary.org/obo/CL_0017000) -### hemocyte (sensu Arthropoda) `http://purl.obolibrary.org/obo/CL_0000387` -#### Removed -- [hemocyte (sensu Arthropoda)](http://purl.obolibrary.org/obo/CL_0000387) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [epithelium of segmental bronchus](http://purl.obolibrary.org/obo/UBERON_0002341) SubClassOf [has part](http://purl.obolibrary.org/obo/BFO_0000051) some [ciliated cell of the bronchus](http://purl.obolibrary.org/obo/CL_0002332) +### erythroid progenitor cell `http://purl.obolibrary.org/obo/CL_0000038` +#### Removed +- [erythroid progenitor cell](http://purl.obolibrary.org/obo/CL_0000038) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "CFU-E" -### hemoglobin subunit zeta `http://purl.obolibrary.org/obo/PR_000008467` +- [erythroid progenitor cell](http://purl.obolibrary.org/obo/CL_0000038) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "BFU-E" #### Added -- [hemoglobin subunit zeta](http://purl.obolibrary.org/obo/PR_000008467) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [hemoglobin subunit zeta (human)](http://purl.obolibrary.org/obo/PR_P02008) +- [erythroid progenitor cell](http://purl.obolibrary.org/obo/CL_0000038) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "CFU-E" + - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation) + +- [erythroid progenitor cell](http://purl.obolibrary.org/obo/CL_0000038) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "BFU-E" + - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation) -### hepatic stellate cell `http://purl.obolibrary.org/obo/CL_0000632` +### erythroid progenitor cell, mammalian `http://purl.obolibrary.org/obo/CL_0001066` #### Removed -- [hepatic stellate cell](http://purl.obolibrary.org/obo/CL_0000632) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [erythroid progenitor cell, mammalian](http://purl.obolibrary.org/obo/CL_0001066) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "CFU-E" + +- [erythroid progenitor cell, mammalian](http://purl.obolibrary.org/obo/CL_0001066) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "BFU-E" + +#### Added +- [erythroid progenitor cell, mammalian](http://purl.obolibrary.org/obo/CL_0001066) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "BFU-E" + - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation) +- [erythroid progenitor cell, mammalian](http://purl.obolibrary.org/obo/CL_0001066) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "CFU-E" + - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation) -### hepatobiliary system `http://purl.obolibrary.org/obo/UBERON_0002423` +### example to be eventually removed `http://purl.obolibrary.org/obo/IAO_0000002` #### Removed -- [hepatobiliary system](http://purl.obolibrary.org/obo/UBERON_0002423) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [example to be eventually removed](http://purl.obolibrary.org/obo/IAO_0000002) [label](http://www.w3.org/2000/01/rdf-schema#label) "example to be eventually removed"@en + +- [example to be eventually removed](http://purl.obolibrary.org/obo/IAO_0000002) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "example to be eventually removed"@en + +- Individual: [example to be eventually removed](http://purl.obolibrary.org/obo/IAO_0000002) -### hepatocyte `http://purl.obolibrary.org/obo/CL_0000182` +### expand expression to `http://purl.obolibrary.org/obo/IAO_0000424` #### Removed -- [hepatocyte](http://purl.obolibrary.org/obo/CL_0000182) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [expand expression to](http://purl.obolibrary.org/obo/IAO_0000424) [IAO_0000112](http://purl.obolibrary.org/obo/IAO_0000112) "ObjectProperty: RO_0002104 +Label: has plasma membrane part +Annotations: IAO_0000424 "http://purl.obolibrary.org/obo/BFO_0000051 some (http://purl.org/obo/owl/GO#GO_0005886 and http://purl.obolibrary.org/obo/BFO_0000051 some ?Y)" +"@en +- [expand expression to](http://purl.obolibrary.org/obo/IAO_0000424) [IAO_0000117](http://purl.obolibrary.org/obo/IAO_0000117) "Chris Mungall"@en +- [expand expression to](http://purl.obolibrary.org/obo/IAO_0000424) [label](http://www.w3.org/2000/01/rdf-schema#label) "expand expression to"@en -### high affinity immunoglobulin epsilon receptor subunit alpha `http://purl.obolibrary.org/obo/PR_000007431` +- [expand expression to](http://purl.obolibrary.org/obo/IAO_0000424) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A macro expansion tag applied to an object property (or possibly a data property) which can be used by a macro-expansion engine to generate more complex expressions from simpler ones"@en + +- [expand expression to](http://purl.obolibrary.org/obo/IAO_0000424) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "expand expression to"@en -#### Added -- [high affinity immunoglobulin epsilon receptor subunit alpha](http://purl.obolibrary.org/obo/PR_000007431) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [high affinity immunoglobulin epsilon receptor subunit alpha (human)](http://purl.obolibrary.org/obo/PR_P12319) -### high affinity immunoglobulin gamma Fc receptor I `http://purl.obolibrary.org/obo/PR_000001465` +### export across plasma membrane `http://purl.obolibrary.org/obo/GO_0140115` #### Added -- [high affinity immunoglobulin gamma Fc receptor I](http://purl.obolibrary.org/obo/PR_000001465) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [high affinity immunoglobulin gamma Fc receptor I (human)](http://purl.obolibrary.org/obo/PR_P12314) +- [export across plasma membrane](http://purl.obolibrary.org/obo/GO_0140115) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" +- [export across plasma membrane](http://purl.obolibrary.org/obo/GO_0140115) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "pg" -### hindgut `http://purl.obolibrary.org/obo/UBERON_0001046` -#### Removed -- [hindgut](http://purl.obolibrary.org/obo/UBERON_0001046) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [export across plasma membrane](http://purl.obolibrary.org/obo/GO_0140115) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2017-10-24T14:38:16Z" +- [export across plasma membrane](http://purl.obolibrary.org/obo/GO_0140115) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "efflux" +- [export across plasma membrane](http://purl.obolibrary.org/obo/GO_0140115) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0140115" -### hip connective tissue `http://purl.obolibrary.org/obo/UBERON_0003576` -#### Removed -- [hip connective tissue](http://purl.obolibrary.org/obo/UBERON_0003576) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [export across plasma membrane](http://purl.obolibrary.org/obo/GO_0140115) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The directed movement of some substance from inside of a cell, across the plasma membrane and into the extracellular region." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:pg" +- [export across plasma membrane](http://purl.obolibrary.org/obo/GO_0140115) [label](http://www.w3.org/2000/01/rdf-schema#label) "export across plasma membrane" +- Class: [export across plasma membrane](http://purl.obolibrary.org/obo/GO_0140115) -### hippocampus granule cell layer `http://purl.obolibrary.org/obo/UBERON_0005367` -#### Removed -- [hippocampus granule cell layer](http://purl.obolibrary.org/obo/UBERON_0005367) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [export across plasma membrane](http://purl.obolibrary.org/obo/GO_0140115) EquivalentTo [transport](http://purl.obolibrary.org/obo/GO_0006810) and ([has target start location](http://purl.obolibrary.org/obo/RO_0002338) some [cytosol](http://purl.obolibrary.org/obo/GO_0005829)) and ([has target end location](http://purl.obolibrary.org/obo/RO_0002339) some [extracellular region](http://purl.obolibrary.org/obo/GO_0005576)) and ([results in transport across](http://purl.obolibrary.org/obo/RO_0002342) some [plasma membrane](http://purl.obolibrary.org/obo/GO_0005886)) +- [export across plasma membrane](http://purl.obolibrary.org/obo/GO_0140115) SubClassOf [has target start location](http://purl.obolibrary.org/obo/RO_0002338) some [cytosol](http://purl.obolibrary.org/obo/GO_0005829) +- [export across plasma membrane](http://purl.obolibrary.org/obo/GO_0140115) SubClassOf [transmembrane transport](http://purl.obolibrary.org/obo/GO_0055085) -### homeobox protein Meis2 `http://purl.obolibrary.org/obo/PR_000010317` +- [export across plasma membrane](http://purl.obolibrary.org/obo/GO_0140115) SubClassOf [results in transport across](http://purl.obolibrary.org/obo/RO_0002342) some [plasma membrane](http://purl.obolibrary.org/obo/GO_0005886) -#### Added -- [homeobox protein Meis2](http://purl.obolibrary.org/obo/PR_000010317) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [homeobox protein Meis2 (human)](http://purl.obolibrary.org/obo/PR_O14770) +- [export across plasma membrane](http://purl.obolibrary.org/obo/GO_0140115) SubClassOf [export from cell](http://purl.obolibrary.org/obo/GO_0140352) -### hyoid arch skeleton `http://purl.obolibrary.org/obo/UBERON_0005884` +### failed exploratory term `http://purl.obolibrary.org/obo/IAO_0000103` #### Removed -- [hyoid arch skeleton](http://purl.obolibrary.org/obo/UBERON_0005884) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [failed exploratory term](http://purl.obolibrary.org/obo/IAO_0000103) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "failed exploratory term"@en +- [failed exploratory term](http://purl.obolibrary.org/obo/IAO_0000103) [IAO_0000117](http://purl.obolibrary.org/obo/IAO_0000117) "Person:Alan Ruttenberg"@en +- [failed exploratory term](http://purl.obolibrary.org/obo/IAO_0000103) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The term was used in an attempt to structure part of the ontology but in retrospect failed to do a good job"@en -### hypoglossal nerve `http://purl.obolibrary.org/obo/UBERON_0001650` -#### Removed -- [hypoglossal nerve](http://purl.obolibrary.org/obo/UBERON_0001650) SubClassOf [neuron projection bundle](http://purl.obolibrary.org/obo/CARO_0001001) +- [failed exploratory term](http://purl.obolibrary.org/obo/IAO_0000103) [label](http://www.w3.org/2000/01/rdf-schema#label) "failed exploratory term"@en + +- Individual: [failed exploratory term](http://purl.obolibrary.org/obo/IAO_0000103) -### hypothalamus kisspeptin neuron `http://purl.obolibrary.org/obo/CL_4023123` +### fibroblast of choroid plexus `http://purl.obolibrary.org/obo/CL_0002549` #### Removed -- [hypothalamus kisspeptin neuron](http://purl.obolibrary.org/obo/CL_4023123) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [fibroblast of choroid plexus](http://purl.obolibrary.org/obo/CL_0002549) SubClassOf [choroid plexus cell](http://purl.obolibrary.org/obo/CL_4023073) +#### Added +- [fibroblast of choroid plexus](http://purl.obolibrary.org/obo/CL_0002549) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [choroid plexus](http://purl.obolibrary.org/obo/UBERON_0001886) -### immature eye `http://purl.obolibrary.org/obo/UBERON_0010312` +### flag amacrine cell `http://purl.obolibrary.org/obo/CL_0004220` #### Removed -- [immature eye](http://purl.obolibrary.org/obo/UBERON_0010312) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [flag amacrine cell](http://purl.obolibrary.org/obo/CL_0004220) SubClassOf [retina horizontal cell](http://purl.obolibrary.org/obo/CL_0000745) -### immature single positive thymocyte `http://purl.obolibrary.org/obo/CL_0000805` +### fountain amacrine cell `http://purl.obolibrary.org/obo/CL_0004237` #### Removed -- [immature single positive thymocyte](http://purl.obolibrary.org/obo/CL_0000805) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [fountain amacrine cell](http://purl.obolibrary.org/obo/CL_0004237) SubClassOf [retina horizontal cell](http://purl.obolibrary.org/obo/CL_0000745) -### immunoglobulin iota chain `http://purl.obolibrary.org/obo/PR_000001858` +### gamma-delta T cell `http://purl.obolibrary.org/obo/CL_0000798` +#### Removed +- [gamma-delta T cell](http://purl.obolibrary.org/obo/CL_0000798) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "gd T cell" #### Added -- [immunoglobulin iota chain](http://purl.obolibrary.org/obo/PR_000001858) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [immunoglobulin iota chain (human)](http://purl.obolibrary.org/obo/PR_P12018) +- [gamma-delta T cell](http://purl.obolibrary.org/obo/CL_0000798) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "gd T cell" + - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation) -### immunoglobulin lambda-like polypeptide 1 `http://purl.obolibrary.org/obo/PR_000001859` +### gene expression `http://purl.obolibrary.org/obo/GO_0010467` +#### Removed +- [gene expression](http://purl.obolibrary.org/obo/GO_0010467) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, translation and maturation for protein-coding genes." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:txnOH-2018" -#### Added -- [immunoglobulin lambda-like polypeptide 1](http://purl.obolibrary.org/obo/PR_000001859) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [immunoglobulin lambda-like polypeptide 1 (human)](http://purl.obolibrary.org/obo/PR_P15814) + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:31580950" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:25934543" -### in taxon `http://purl.obolibrary.org/obo/RO_0002162` -#### Removed -- [in taxon](http://purl.obolibrary.org/obo/RO_0002162) Range [organism](http://purl.obolibrary.org/obo/CARO_0001010) +- [gene expression](http://purl.obolibrary.org/obo/GO_0010467) SubClassOf [macromolecule metabolic process](http://purl.obolibrary.org/obo/GO_0043170) +#### Added +- [gene expression](http://purl.obolibrary.org/obo/GO_0010467) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, as well as translation and maturation for protein-coding genes." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:txnOH-2018" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:31580950" -### independent continuant `http://purl.obolibrary.org/obo/BFO_0000004` -#### Removed -- [independent continuant](http://purl.obolibrary.org/obo/BFO_0000004) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A continuant that is a bearer of quality and realizable entity entities, in which other entities inhere and which itself cannot inhere in anything."@en + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:25934543" -#### Added -- [independent continuant](http://purl.obolibrary.org/obo/BFO_0000004) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "A continuant that is a bearer of quality and realizable entity entities, in which other entities inhere and which itself cannot inhere in anything."@en +- [gene expression](http://purl.obolibrary.org/obo/GO_0010467) [term tracker item](http://purl.obolibrary.org/obo/IAO_0000233) "https://github.com/geneontology/go-ontology/issues/25419"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI) -- [independent continuant](http://purl.obolibrary.org/obo/BFO_0000004) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "b is an independent continuant = Def. b is a continuant which is such that there is no c and no t such that b s-depends_on c at t. (axiom label in BFO2 Reference: [017-002])"@en +- [gene expression](http://purl.obolibrary.org/obo/GO_0010467) SubClassOf [macromolecule biosynthetic process](http://purl.obolibrary.org/obo/GO_0009059) -### indirectly causally upstream of `http://purl.obolibrary.org/obo/RO_0012011` -#### Removed -- [indirectly causally upstream of](http://purl.obolibrary.org/obo/RO_0012011) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "pg" +### germline ring canal `http://purl.obolibrary.org/obo/GO_0045172` #### Added -- [indirectly causally upstream of](http://purl.obolibrary.org/obo/RO_0012011) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) [0000-0003-1813-6857](https://orcid.org/0000-0003-1813-6857) +- [germline ring canal](http://purl.obolibrary.org/obo/GO_0045172) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0045172" +- [germline ring canal](http://purl.obolibrary.org/obo/GO_0045172) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Germline specific intercellular bridge. During cyst formation in insects, ring canals interconnect the cells of the cyst, facilitating the passage of cytoplasmic components between cells." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:9635420" -### indirectly negatively regulates `http://purl.obolibrary.org/obo/RO_0002409` + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:mtg_sensu" -#### Added -- [indirectly negatively regulates](http://purl.obolibrary.org/obo/RO_0002409) [see also](http://www.w3.org/2000/01/rdf-schema#seeAlso) "https://wiki.geneontology.org/Indirectly_negatively_regulates"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI) + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:9655801" +- [germline ring canal](http://purl.obolibrary.org/obo/GO_0045172) [label](http://www.w3.org/2000/01/rdf-schema#label) "germline ring canal" -### indirectly positively regulates `http://purl.obolibrary.org/obo/RO_0002407` +- [germline ring canal](http://purl.obolibrary.org/obo/GO_0045172) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "cellular_component" -#### Added -- [indirectly positively regulates](http://purl.obolibrary.org/obo/RO_0002407) [see also](http://www.w3.org/2000/01/rdf-schema#seeAlso) "https://wiki.geneontology.org/Indirectly_positively_regulates"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI) +- Class: [germline ring canal](http://purl.obolibrary.org/obo/GO_0045172) +- [germline ring canal](http://purl.obolibrary.org/obo/GO_0045172) SubClassOf [only in taxon](http://purl.obolibrary.org/obo/RO_0002160) some [Arthropoda](http://purl.obolibrary.org/obo/NCBITaxon_6656) -### indirectly regulates `http://purl.obolibrary.org/obo/RO_0012012` -#### Removed -- [indirectly regulates](http://purl.obolibrary.org/obo/RO_0012012) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "pg" +- [germline ring canal](http://purl.obolibrary.org/obo/GO_0045172) SubClassOf [in taxon](http://purl.obolibrary.org/obo/RO_0002162) only [Arthropoda](http://purl.obolibrary.org/obo/NCBITaxon_6656) -#### Added -- [indirectly regulates](http://purl.obolibrary.org/obo/RO_0012012) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) [0000-0003-1813-6857](https://orcid.org/0000-0003-1813-6857) +- [germline ring canal](http://purl.obolibrary.org/obo/GO_0045172) SubClassOf [intercellular bridge](http://purl.obolibrary.org/obo/GO_0045171) -### individual digit of digitopodial skeleton `http://purl.obolibrary.org/obo/UBERON_5102544` +### glial cell-neuron signaling `http://purl.obolibrary.org/obo/GO_0150098` #### Removed -- [individual digit of digitopodial skeleton](http://purl.obolibrary.org/obo/UBERON_5102544) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000) +- [glial cell-neuron signaling](http://purl.obolibrary.org/obo/GO_0150098) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Cell-cell signaling that mediates the transfer of information from a glial cell to a neuron. This signaling has been shown to be mediated by various molecules, depending on which glial cells release them, and in which tissues the signalling occurs, e.g. microglial cell-derived nerve growth factor (NGF) in the retina, or microglial cell-derived superoxide ions in the cerebellum." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:14980203" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:9459440" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:27788368" -### inducible T-cell costimulator `http://purl.obolibrary.org/obo/PR_000001860` + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:18685038" -#### Added -- [inducible T-cell costimulator](http://purl.obolibrary.org/obo/PR_000001860) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [inducible T-cell costimulator (human)](http://purl.obolibrary.org/obo/PR_Q9Y6W8) + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:16547515" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:bc" -### information content entity `http://purl.obolibrary.org/obo/IAO_0000030` + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:16144764" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:aruk" #### Added -- [information content entity](http://purl.obolibrary.org/obo/IAO_0000030) [IAO_0000112](http://purl.obolibrary.org/obo/IAO_0000112) "Examples of information content entites include journal articles, data, graphical layouts, and graphs."@en +- [glial cell-neuron signaling](http://purl.obolibrary.org/obo/GO_0150098) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Cell-cell signaling that mediates the transfer of information from a glial cell to a neuron. This signaling has been shown to be mediated by various molecules, depending on which glial cells release them, and in which tissues the signaling occurs, e.g. microglial cell-derived nerve growth factor (NGF) in the retina, or microglial cell-derived superoxide ions in the cerebellum." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:14980203" -- [information content entity](http://purl.obolibrary.org/obo/IAO_0000030) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "information content entity"@en + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:9459440" -- [information content entity](http://purl.obolibrary.org/obo/IAO_0000030) [editor note](http://purl.obolibrary.org/obo/IAO_0000116) "2014-03-10: The use of "thing" is intended to be general enough to include universals and configurations (see https://groups.google.com/d/msg/information-ontology/GBxvYZCk1oc/-L6B5fSBBTQJ)."@en + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:27788368" -- [information content entity](http://purl.obolibrary.org/obo/IAO_0000030) [editor note](http://purl.obolibrary.org/obo/IAO_0000116) "information_content_entity 'is_encoded_in' some digital_entity in obi before split (040907). information_content_entity 'is_encoded_in' some physical_document in obi before split (040907). + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:18685038" -Previous. An information content entity is a non-realizable information entity that 'is encoded in' some digital or physical entity."@en + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:16547515" -- [information content entity](http://purl.obolibrary.org/obo/IAO_0000030) [IAO_0000119](http://purl.obolibrary.org/obo/IAO_0000119) "OBI_0000142"@en + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:bc" -- [information content entity](http://purl.obolibrary.org/obo/IAO_0000030) [IAO_0000117](http://purl.obolibrary.org/obo/IAO_0000117) "PERSON: Chris Stoeckert"@en + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:16144764" -- [information content entity](http://purl.obolibrary.org/obo/IAO_0000030) [IAO_0000114](http://purl.obolibrary.org/obo/IAO_0000114) [ready for release](http://purl.obolibrary.org/obo/IAO_0000122) + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:aruk" -- [information content entity](http://purl.obolibrary.org/obo/IAO_0000030) [label](http://www.w3.org/2000/01/rdf-schema#label) "information content entity"@en -- [information content entity](http://purl.obolibrary.org/obo/IAO_0000030) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A generically dependent continuant that is about some thing."@en +### glucose import across plasma membrane `http://purl.obolibrary.org/obo/GO_0098708` -- Class: [information content entity](http://purl.obolibrary.org/obo/IAO_0000030) +#### Added +- [glucose import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098708) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0098708" -- [information content entity](http://purl.obolibrary.org/obo/IAO_0000030) SubClassOf [is about](http://purl.obolibrary.org/obo/IAO_0000136) some [BFO_0000001](http://purl.obolibrary.org/obo/BFO_0000001) +- [glucose import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098708) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "al" -- [information content entity](http://purl.obolibrary.org/obo/IAO_0000030) SubClassOf [generically dependent continuant](http://purl.obolibrary.org/obo/BFO_0000031) +- [glucose import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098708) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2012-12-06T14:54:07Z" +- [glucose import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098708) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "high affinity glucose import" -### inner cell mass `http://purl.obolibrary.org/obo/UBERON_0000087` -#### Removed -- [inner cell mass](http://purl.obolibrary.org/obo/UBERON_0000087) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [glucose import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098708) [has_alternative_id](http://www.geneontology.org/formats/oboInOwl#hasAlternativeId) "GO:1990821" +- [glucose import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098708) [has_alternative_id](http://www.geneontology.org/formats/oboInOwl#hasAlternativeId) "GO:0061490" +- [glucose import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098708) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The directed movement of glucose from outside of a cell, across the plasma membrane and into the cytosol." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dos" -### inner cell mass derived epiblast `http://purl.obolibrary.org/obo/UBERON_0008780` -#### Removed -- [inner cell mass derived epiblast](http://purl.obolibrary.org/obo/UBERON_0008780) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [glucose import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098708) [label](http://www.w3.org/2000/01/rdf-schema#label) "glucose import across plasma membrane" +- [glucose import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098708) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" +- [glucose import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098708) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "glucose import into cell" -### inner limiting layer of retina `http://purl.obolibrary.org/obo/UBERON_0001794` -#### Removed -- [inner limiting layer of retina](http://purl.obolibrary.org/obo/UBERON_0001794) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- Class: [glucose import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098708) +- [glucose import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098708) EquivalentTo [transport](http://purl.obolibrary.org/obo/GO_0006810) and ([has target start location](http://purl.obolibrary.org/obo/RO_0002338) some [extracellular region](http://purl.obolibrary.org/obo/GO_0005576)) and ([has target end location](http://purl.obolibrary.org/obo/RO_0002339) some [cytosol](http://purl.obolibrary.org/obo/GO_0005829)) and ([results in transport across](http://purl.obolibrary.org/obo/RO_0002342) some [plasma membrane](http://purl.obolibrary.org/obo/GO_0005886)) and ([has primary input](http://purl.obolibrary.org/obo/RO_0004009) some [CHEBI_17234](http://purl.obolibrary.org/obo/CHEBI_17234)) +- [glucose import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098708) SubClassOf [glucose transmembrane transport](http://purl.obolibrary.org/obo/GO_1904659) -### inner nuclear layer of retina `http://purl.obolibrary.org/obo/UBERON_0001791` -#### Removed -- [inner nuclear layer of retina](http://purl.obolibrary.org/obo/UBERON_0001791) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [glucose import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098708) SubClassOf [import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098739) +### glutamate transmembrane import into vacuole `http://purl.obolibrary.org/obo/GO_0090454` -### innervated_by `http://purl.obolibrary.org/obo/RO_0002005` -#### Removed -- [innervated_by](http://purl.obolibrary.org/obo/RO_0002005) Domain [connected anatomical structure](http://purl.obolibrary.org/obo/CARO_0000003) +#### Added +- [glutamate transmembrane import into vacuole](http://purl.obolibrary.org/obo/GO_0090454) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2012-09-24T14:12:46Z" -- [innervated_by](http://purl.obolibrary.org/obo/RO_0002005) Range [neuron projection bundle](http://purl.obolibrary.org/obo/CARO_0001001) +- [glutamate transmembrane import into vacuole](http://purl.obolibrary.org/obo/GO_0090454) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The directed movement of glutamate into the vacuole across the vacuolar membrane." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:tb" -#### Added -- [innervated_by](http://purl.obolibrary.org/obo/RO_0002005) Domain [anatomical structure](http://purl.obolibrary.org/obo/UBERON_0000061) +- [glutamate transmembrane import into vacuole](http://purl.obolibrary.org/obo/GO_0090454) [label](http://www.w3.org/2000/01/rdf-schema#label) "glutamate transmembrane import into vacuole" -- [innervated_by](http://purl.obolibrary.org/obo/RO_0002005) Range [neuron projection bundle](http://purl.obolibrary.org/obo/UBERON_0000122) +- [glutamate transmembrane import into vacuole](http://purl.obolibrary.org/obo/GO_0090454) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "vacuolar glutamate import" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:tb" +- [glutamate transmembrane import into vacuole](http://purl.obolibrary.org/obo/GO_0090454) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0090454" -### innervates `http://purl.obolibrary.org/obo/RO_0002134` -#### Removed -- [innervates](http://purl.obolibrary.org/obo/RO_0002134) Domain [neuron projection bundle](http://purl.obolibrary.org/obo/CARO_0001001) +- [glutamate transmembrane import into vacuole](http://purl.obolibrary.org/obo/GO_0090454) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" -#### Added -- [innervates](http://purl.obolibrary.org/obo/RO_0002134) Domain [neuron projection bundle](http://purl.obolibrary.org/obo/UBERON_0000122) +- [glutamate transmembrane import into vacuole](http://purl.obolibrary.org/obo/GO_0090454) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "tb" +- Class: [glutamate transmembrane import into vacuole](http://purl.obolibrary.org/obo/GO_0090454) -### insulin gene translation product `http://purl.obolibrary.org/obo/PR_000009054` - -#### Added -- [insulin gene translation product](http://purl.obolibrary.org/obo/PR_000009054) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [insulin gene translation product (human)](http://purl.obolibrary.org/obo/PR_P01308) +- [glutamate transmembrane import into vacuole](http://purl.obolibrary.org/obo/GO_0090454) EquivalentTo [acidic amino acid transport](http://purl.obolibrary.org/obo/GO_0015800) and ([has target start location](http://purl.obolibrary.org/obo/RO_0002338) some [cytosol](http://purl.obolibrary.org/obo/GO_0005829)) and ([has target end location](http://purl.obolibrary.org/obo/RO_0002339) some [vacuolar lumen](http://purl.obolibrary.org/obo/GO_0005775)) and ([results in transport across](http://purl.obolibrary.org/obo/RO_0002342) some [membrane](http://purl.obolibrary.org/obo/GO_0016020)) and ([has primary input](http://purl.obolibrary.org/obo/RO_0004009) some [CHEBI_14321](http://purl.obolibrary.org/obo/CHEBI_14321)) +- [glutamate transmembrane import into vacuole](http://purl.obolibrary.org/obo/GO_0090454) SubClassOf [acidic amino acid transport](http://purl.obolibrary.org/obo/GO_0015800) -### integrin alpha-2 `http://purl.obolibrary.org/obo/PR_000001008` +- [glutamate transmembrane import into vacuole](http://purl.obolibrary.org/obo/GO_0090454) SubClassOf [has primary input](http://purl.obolibrary.org/obo/RO_0004009) some [CHEBI_14321](http://purl.obolibrary.org/obo/CHEBI_14321) -#### Added -- [integrin alpha-2](http://purl.obolibrary.org/obo/PR_000001008) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [integrin alpha-2 (human)](http://purl.obolibrary.org/obo/PR_P17301) +- [glutamate transmembrane import into vacuole](http://purl.obolibrary.org/obo/GO_0090454) SubClassOf [amino acid transmembrane import into vacuole](http://purl.obolibrary.org/obo/GO_0032975) -### integrin alpha-4 `http://purl.obolibrary.org/obo/PR_000009129` +### glycine import across plasma membrane `http://purl.obolibrary.org/obo/GO_1903804` #### Added -- [integrin alpha-4](http://purl.obolibrary.org/obo/PR_000009129) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [integrin alpha-4 (human)](http://purl.obolibrary.org/obo/PR_P13612) - +- [glycine import across plasma membrane](http://purl.obolibrary.org/obo/GO_1903804) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "bf" -### integrin alpha-E `http://purl.obolibrary.org/obo/PR_000001010` +- [glycine import across plasma membrane](http://purl.obolibrary.org/obo/GO_1903804) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "glycine import" -#### Added -- [integrin alpha-E](http://purl.obolibrary.org/obo/PR_000001010) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [integrin alpha-E (human)](http://purl.obolibrary.org/obo/PR_P38570) +- [glycine import across plasma membrane](http://purl.obolibrary.org/obo/GO_1903804) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The directed movement of glycine from outside of a cell, across the plasma membrane and into the cytosol." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:23895341" -### integrin alpha-IIb `http://purl.obolibrary.org/obo/PR_000009127` + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GO_REF:0000075" -#### Added -- [integrin alpha-IIb](http://purl.obolibrary.org/obo/PR_000009127) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [integrin alpha-IIb (human)](http://purl.obolibrary.org/obo/PR_P08514) +- [glycine import across plasma membrane](http://purl.obolibrary.org/obo/GO_1903804) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" +- [glycine import across plasma membrane](http://purl.obolibrary.org/obo/GO_1903804) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2012-05-11T01:16:45Z" -### integrin alpha-M `http://purl.obolibrary.org/obo/PR_000001012` +- [glycine import across plasma membrane](http://purl.obolibrary.org/obo/GO_1903804) [label](http://www.w3.org/2000/01/rdf-schema#label) "glycine import across plasma membrane" -#### Added -- [integrin alpha-M](http://purl.obolibrary.org/obo/PR_000001012) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [integrin alpha-M (human)](http://purl.obolibrary.org/obo/PR_P11215) +- [glycine import across plasma membrane](http://purl.obolibrary.org/obo/GO_1903804) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "glycine import into cell" +- [glycine import across plasma membrane](http://purl.obolibrary.org/obo/GO_1903804) [has_alternative_id](http://www.geneontology.org/formats/oboInOwl#hasAlternativeId) "GO:0036233" -### integrin alpha-X `http://purl.obolibrary.org/obo/PR_000001013` +- [glycine import across plasma membrane](http://purl.obolibrary.org/obo/GO_1903804) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:1903804" -#### Added -- [integrin alpha-X](http://purl.obolibrary.org/obo/PR_000001013) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [integrin alpha-X (human)](http://purl.obolibrary.org/obo/PR_P20702) +- Class: [glycine import across plasma membrane](http://purl.obolibrary.org/obo/GO_1903804) +- [glycine import across plasma membrane](http://purl.obolibrary.org/obo/GO_1903804) EquivalentTo [transport](http://purl.obolibrary.org/obo/GO_0006810) and ([has target start location](http://purl.obolibrary.org/obo/RO_0002338) some [extracellular region](http://purl.obolibrary.org/obo/GO_0005576)) and ([has target end location](http://purl.obolibrary.org/obo/RO_0002339) some [cytosol](http://purl.obolibrary.org/obo/GO_0005829)) and ([results in transport across](http://purl.obolibrary.org/obo/RO_0002342) some [plasma membrane](http://purl.obolibrary.org/obo/GO_0005886)) and ([has primary input](http://purl.obolibrary.org/obo/RO_0004009) some [CHEBI_57305](http://purl.obolibrary.org/obo/CHEBI_57305)) -### integrin beta-7 `http://purl.obolibrary.org/obo/PR_000009143` +- [glycine import across plasma membrane](http://purl.obolibrary.org/obo/GO_1903804) SubClassOf [glycine transport](http://purl.obolibrary.org/obo/GO_0015816) -#### Added -- [integrin beta-7](http://purl.obolibrary.org/obo/PR_000009143) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [integrin beta-7 (human)](http://purl.obolibrary.org/obo/PR_P26010) +- [glycine import across plasma membrane](http://purl.obolibrary.org/obo/GO_1903804) SubClassOf [amino acid import across plasma membrane](http://purl.obolibrary.org/obo/GO_0089718) -### integument `http://purl.obolibrary.org/obo/UBERON_0002199` +### granulocyte monocyte progenitor cell `http://purl.obolibrary.org/obo/CL_0000557` #### Removed -- [integument](http://purl.obolibrary.org/obo/UBERON_0002199) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) - +- [granulocyte monocyte progenitor cell](http://purl.obolibrary.org/obo/CL_0000557) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "GMP" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMCID:PMC548021" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ISBN:0721601464" -### integumental system `http://purl.obolibrary.org/obo/UBERON_0002416` -#### Removed -- [integumental system](http://purl.obolibrary.org/obo/UBERON_0002416) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMCID:PMC2213186" +- [granulocyte monocyte progenitor cell](http://purl.obolibrary.org/obo/CL_0000557) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "CFU-GM" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMCID:PMC548021" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ISBN:0721601464" -### interleukin-1 receptor-like 1 `http://purl.obolibrary.org/obo/PR_000008994` + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMCID:PMC2213186" #### Added -- [interleukin-1 receptor-like 1](http://purl.obolibrary.org/obo/PR_000008994) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [interleukin-1 receptor-like 1 (human)](http://purl.obolibrary.org/obo/PR_Q01638) - +- [granulocyte monocyte progenitor cell](http://purl.obolibrary.org/obo/CL_0000557) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "GMP" + - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation) -### interleukin-17 receptor B `http://purl.obolibrary.org/obo/PR_000008982` + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMCID:PMC548021" -#### Added -- [interleukin-17 receptor B](http://purl.obolibrary.org/obo/PR_000008982) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [interleukin-17 receptor B (human)](http://purl.obolibrary.org/obo/PR_Q9NRM6) + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ISBN:0721601464" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMCID:PMC2213186" -### interleukin-2 receptor subunit alpha `http://purl.obolibrary.org/obo/PR_000001380` +- [granulocyte monocyte progenitor cell](http://purl.obolibrary.org/obo/CL_0000557) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "CFU-GM" + - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation) -#### Added -- [interleukin-2 receptor subunit alpha](http://purl.obolibrary.org/obo/PR_000001380) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [interleukin-2 receptor subunit alpha (human)](http://purl.obolibrary.org/obo/PR_P01589) + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMCID:PMC548021" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ISBN:0721601464" -### interleukin-2 receptor subunit beta `http://purl.obolibrary.org/obo/PR_000001381` + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMCID:PMC2213186" -#### Added -- [interleukin-2 receptor subunit beta](http://purl.obolibrary.org/obo/PR_000001381) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [interleukin-2 receptor subunit beta (human)](http://purl.obolibrary.org/obo/PR_P14784) +### has obsolescence reason `http://purl.obolibrary.org/obo/IAO_0000231` +#### Removed +- [has obsolescence reason](http://purl.obolibrary.org/obo/IAO_0000231) [IAO_0000117](http://purl.obolibrary.org/obo/IAO_0000117) "PERSON:Alan Ruttenberg"@en -### interleukin-5 receptor subunit alpha `http://purl.obolibrary.org/obo/PR_000001867` +- [has obsolescence reason](http://purl.obolibrary.org/obo/IAO_0000231) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Relates an annotation property to an obsolescence reason. The values of obsolescence reasons come from a list of predefined terms, instances of the class obsolescence reason specification."@en -#### Added -- [interleukin-5 receptor subunit alpha](http://purl.obolibrary.org/obo/PR_000001867) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [interleukin-5 receptor subunit alpha (human)](http://purl.obolibrary.org/obo/PR_Q01344) +- [has obsolescence reason](http://purl.obolibrary.org/obo/IAO_0000231) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "has obsolescence reason"@en +- [has obsolescence reason](http://purl.obolibrary.org/obo/IAO_0000231) [IAO_0000117](http://purl.obolibrary.org/obo/IAO_0000117) "PERSON:Melanie Courtot"@en -### interleukin-7 receptor subunit alpha `http://purl.obolibrary.org/obo/PR_000001869` +- [has obsolescence reason](http://purl.obolibrary.org/obo/IAO_0000231) [label](http://www.w3.org/2000/01/rdf-schema#label) "has obsolescence reason"@en -#### Added -- [interleukin-7 receptor subunit alpha](http://purl.obolibrary.org/obo/PR_000001869) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [interleukin-7 receptor subunit alpha (human)](http://purl.obolibrary.org/obo/PR_P16871) -### intermaxillary process `http://purl.obolibrary.org/obo/UBERON_0009714` +### has ontology root term `http://purl.obolibrary.org/obo/IAO_0000700` #### Removed -- [intermaxillary process](http://purl.obolibrary.org/obo/UBERON_0009714) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [has ontology root term](http://purl.obolibrary.org/obo/IAO_0000700) [label](http://www.w3.org/2000/01/rdf-schema#label) "has ontology root term"@en +- [has ontology root term](http://purl.obolibrary.org/obo/IAO_0000700) [IAO_0000117](http://purl.obolibrary.org/obo/IAO_0000117) "Nicolas Matentzoglu"@en +- [has ontology root term](http://purl.obolibrary.org/obo/IAO_0000700) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Ontology annotation property. Relates an ontology to a term that is a designated root term of the ontology. Display tools like OLS can use terms annotated with this property as the starting point for rendering the ontology class hierarchy. There can be more than one root."@en -### intermediate cell of urothelium `http://purl.obolibrary.org/obo/CL_4030055` -#### Removed -- [intermediate cell of urothelium](http://purl.obolibrary.org/obo/CL_4030055) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "urothelial intermediate cell" - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1007/978-3-030-14366-4_8" +- [has ontology root term](http://purl.obolibrary.org/obo/IAO_0000700) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "has ontology root term"@en #### Added -- [intermediate cell of urothelium](http://purl.obolibrary.org/obo/CL_4030055) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "urothelial intermediate cell" - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1007/978-3-030-14366-4_8" +- [has ontology root term](http://purl.obolibrary.org/obo/IAO_0000700) [is_class_level](http://www.geneontology.org/formats/oboInOwl#is_class_level) true + +- [has ontology root term](http://purl.obolibrary.org/obo/IAO_0000700) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "external" -### intermediate mesoderm `http://purl.obolibrary.org/obo/UBERON_0003064` +### has participant `http://purl.obolibrary.org/obo/RO_0000057` #### Removed -- [intermediate mesoderm](http://purl.obolibrary.org/obo/UBERON_0003064) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [has participant](http://purl.obolibrary.org/obo/RO_0000057) [source](http://purl.org/dc/elements/1.1/source) "http://www.obofoundry.org/ro/#OBO_REL:has_participant" +#### Added +- [has participant](http://purl.obolibrary.org/obo/RO_0000057) [source](http://purl.org/dc/terms/source) "http://www.obofoundry.org/ro/#OBO_REL:has_participant" -### internal ear `http://purl.obolibrary.org/obo/UBERON_0001846` +### hematopoietic stem cell `http://purl.obolibrary.org/obo/CL_0000037` #### Removed -- [internal ear](http://purl.obolibrary.org/obo/UBERON_0001846) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [hematopoietic stem cell](http://purl.obolibrary.org/obo/CL_0000037) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "HSC" +#### Added +- [hematopoietic stem cell](http://purl.obolibrary.org/obo/CL_0000037) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "HSC" + - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation) -### interneuromast cell `http://purl.obolibrary.org/obo/CL_0000854` +### hepatic stem cell `http://purl.obolibrary.org/obo/CL_0002195` #### Removed -- [interneuromast cell](http://purl.obolibrary.org/obo/CL_0000854) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) - +- [hepatic stem cell](http://purl.obolibrary.org/obo/CL_0002195) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "HpSC" + - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation) + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:18442648" -### interplexiform cell `http://purl.obolibrary.org/obo/CL_0011104` -#### Removed -- [interplexiform cell](http://purl.obolibrary.org/obo/CL_0011104) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +#### Added +- [hepatic stem cell](http://purl.obolibrary.org/obo/CL_0002195) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "HpSC" + - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation) + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:18442648" -### interventricular septum membranous part `http://purl.obolibrary.org/obo/UBERON_0004666` -#### Removed -- [interventricular septum membranous part](http://purl.obolibrary.org/obo/UBERON_0004666) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +### hexose import across plasma membrane `http://purl.obolibrary.org/obo/GO_0140271` +#### Added +- [hexose import across plasma membrane](http://purl.obolibrary.org/obo/GO_0140271) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" +- [hexose import across plasma membrane](http://purl.obolibrary.org/obo/GO_0140271) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0140271" -### intestinal villus `http://purl.obolibrary.org/obo/UBERON_0001213` -#### Removed -- [intestinal villus](http://purl.obolibrary.org/obo/UBERON_0001213) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [hexose import across plasma membrane](http://purl.obolibrary.org/obo/GO_0140271) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2018-10-01T08:49:49Z" +- [hexose import across plasma membrane](http://purl.obolibrary.org/obo/GO_0140271) [label](http://www.w3.org/2000/01/rdf-schema#label) "hexose import across plasma membrane" +- [hexose import across plasma membrane](http://purl.obolibrary.org/obo/GO_0140271) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The directed movement of hexose from outside of a cell, across the plasma membrane and into the cytosol." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:10735857" -### intraembryonic coelom `http://purl.obolibrary.org/obo/UBERON_0003887` -#### Removed -- [intraembryonic coelom](http://purl.obolibrary.org/obo/UBERON_0003887) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [hexose import across plasma membrane](http://purl.obolibrary.org/obo/GO_0140271) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "pg" +- Class: [hexose import across plasma membrane](http://purl.obolibrary.org/obo/GO_0140271) +- [hexose import across plasma membrane](http://purl.obolibrary.org/obo/GO_0140271) EquivalentTo [transport](http://purl.obolibrary.org/obo/GO_0006810) and ([has target start location](http://purl.obolibrary.org/obo/RO_0002338) some [extracellular region](http://purl.obolibrary.org/obo/GO_0005576)) and ([has target end location](http://purl.obolibrary.org/obo/RO_0002339) some [cytosol](http://purl.obolibrary.org/obo/GO_0005829)) and ([results in transport across](http://purl.obolibrary.org/obo/RO_0002342) some [plasma membrane](http://purl.obolibrary.org/obo/GO_0005886)) and ([has primary input](http://purl.obolibrary.org/obo/RO_0004009) some [CHEBI_18133](http://purl.obolibrary.org/obo/CHEBI_18133)) -### intratelencephalic-projecting glutamatergic cortical neuron `http://purl.obolibrary.org/obo/CL_4023008` +- [hexose import across plasma membrane](http://purl.obolibrary.org/obo/GO_0140271) SubClassOf [import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098739) -#### Added -- [intratelencephalic-projecting glutamatergic cortical neuron](http://purl.obolibrary.org/obo/CL_4023008) [symbol](http://purl.obolibrary.org/obo/IAO_0000028) "IT glut" +- [hexose import across plasma membrane](http://purl.obolibrary.org/obo/GO_0140271) SubClassOf [hexose transmembrane transport](http://purl.obolibrary.org/obo/GO_0008645) -### invertebrate nurse cell `http://purl.obolibrary.org/obo/CL_0000026` +### hippocampal mossy fiber `http://purl.obolibrary.org/obo/GO_0097457` #### Removed -- [invertebrate nurse cell](http://purl.obolibrary.org/obo/CL_0000026) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [hippocampal mossy fiber](http://purl.obolibrary.org/obo/GO_0097457) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [hippocampal granule cell](http://purl.obolibrary.org/obo/CL_0001033) -### inverted L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (Mmus) `http://purl.obolibrary.org/obo/CL_4023081` +### histamine uptake `http://purl.obolibrary.org/obo/GO_0051615` #### Added -- [inverted L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (Mmus)](http://purl.obolibrary.org/obo/CL_4023081) [symbol](http://purl.obolibrary.org/obo/IAO_0000028) "inverted L6 IT glut MOp" +- [histamine uptake](http://purl.obolibrary.org/obo/GO_0051615) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The directed movement of histamine into a cell, typically presynaptic neurons or glial cells. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:ai" +- [histamine uptake](http://purl.obolibrary.org/obo/GO_0051615) [label](http://www.w3.org/2000/01/rdf-schema#label) "histamine uptake" -### involved in `http://purl.obolibrary.org/obo/RO_0002331` -#### Removed -- [involved in](http://purl.obolibrary.org/obo/RO_0002331) [see also](http://www.w3.org/2000/01/rdf-schema#seeAlso) [Involved_in](http://wiki.geneontology.org/index.php/Involved_in) +- [histamine uptake](http://purl.obolibrary.org/obo/GO_0051615) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0051615" -#### Added -- [involved in](http://purl.obolibrary.org/obo/RO_0002331) [see also](http://www.w3.org/2000/01/rdf-schema#seeAlso) "https://wiki.geneontology.org/Involved_in"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI) +- [histamine uptake](http://purl.obolibrary.org/obo/GO_0051615) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "histamine import" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dph" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:tb" -### iridophore `http://purl.obolibrary.org/obo/CL_0000431` -#### Removed -- [iridophore](http://purl.obolibrary.org/obo/CL_0000431) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [histamine uptake](http://purl.obolibrary.org/obo/GO_0051615) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" +- Class: [histamine uptake](http://purl.obolibrary.org/obo/GO_0051615) +- [histamine uptake](http://purl.obolibrary.org/obo/GO_0051615) EquivalentTo [transport](http://purl.obolibrary.org/obo/GO_0006810) and ([has target start location](http://purl.obolibrary.org/obo/RO_0002338) some [extracellular region](http://purl.obolibrary.org/obo/GO_0005576)) and ([has target end location](http://purl.obolibrary.org/obo/RO_0002339) some [cytosol](http://purl.obolibrary.org/obo/GO_0005829)) and ([has primary input](http://purl.obolibrary.org/obo/RO_0004009) some [CHEBI_58432](http://purl.obolibrary.org/obo/CHEBI_58432)) -### iris nerve `http://purl.obolibrary.org/obo/UBERON_0003438` -#### Removed -- [iris nerve](http://purl.obolibrary.org/obo/UBERON_0003438) SubClassOf [neuron projection bundle](http://purl.obolibrary.org/obo/CARO_0001001) +- [histamine uptake](http://purl.obolibrary.org/obo/GO_0051615) SubClassOf [has target end location](http://purl.obolibrary.org/obo/RO_0002339) some [cytosol](http://purl.obolibrary.org/obo/GO_0005829) +- [histamine uptake](http://purl.obolibrary.org/obo/GO_0051615) SubClassOf [histamine transport](http://purl.obolibrary.org/obo/GO_0051608) +- [histamine uptake](http://purl.obolibrary.org/obo/GO_0051615) SubClassOf [neurotransmitter uptake](http://purl.obolibrary.org/obo/GO_0001504) -### is about `http://purl.obolibrary.org/obo/IAO_0000136` +- [histamine uptake](http://purl.obolibrary.org/obo/GO_0051615) SubClassOf [has target start location](http://purl.obolibrary.org/obo/RO_0002338) some [extracellular region](http://purl.obolibrary.org/obo/GO_0005576) -#### Added -- [is about](http://purl.obolibrary.org/obo/IAO_0000136) [IAO_0000117](http://purl.obolibrary.org/obo/IAO_0000117) "person:Alan Ruttenberg"@en -- [is about](http://purl.obolibrary.org/obo/IAO_0000136) [IAO_0000114](http://purl.obolibrary.org/obo/IAO_0000114) [pending final vetting](http://purl.obolibrary.org/obo/IAO_0000125) +### hydrolase activity, acting on acid anhydrides `http://purl.obolibrary.org/obo/GO_0016817` +#### Removed +- [hydrolase activity, acting on acid anhydrides](http://purl.obolibrary.org/obo/GO_0016817) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "molecular_function" -- [is about](http://purl.obolibrary.org/obo/IAO_0000136) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A (currently) primitive relation that relates an information artifact to an entity."@en +- [hydrolase activity, acting on acid anhydrides](http://purl.obolibrary.org/obo/GO_0016817) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Catalysis of the hydrolysis of any acid anhydride." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:jl" -- [is about](http://purl.obolibrary.org/obo/IAO_0000136) [IAO_0000119](http://purl.obolibrary.org/obo/IAO_0000119) "Smith, Ceusters, Ruttenberg, 2000 years of philosophy"@en +- [hydrolase activity, acting on acid anhydrides](http://purl.obolibrary.org/obo/GO_0016817) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0016817" -- [is about](http://purl.obolibrary.org/obo/IAO_0000136) [editor note](http://purl.obolibrary.org/obo/IAO_0000116) "7/6/2009 Alan Ruttenberg. Following discussion with Jonathan Rees, and introduction of "mentions" relation. Weaken the is_about relationship to be primitive. +- [hydrolase activity, acting on acid anhydrides](http://purl.obolibrary.org/obo/GO_0016817) [label](http://www.w3.org/2000/01/rdf-schema#label) "hydrolase activity, acting on acid anhydrides" -We will try to build it back up by elaborating the various subproperties that are more precisely defined. +- [hydrolase activity, acting on acid anhydrides](http://purl.obolibrary.org/obo/GO_0016817) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "EC:3.6.-.-" -Some currently missing phenomena that should be considered "about" are predications - "The only person who knows the answer is sitting beside me" , Allegory, Satire, and other literary forms that can be topical without explicitly mentioning the topic."@en +- [hydrolase activity, acting on acid anhydrides](http://purl.obolibrary.org/obo/GO_0016817) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "hydrolase activity, acting on acid anhydrides, involved in cellular and subcellular movement" -- [is about](http://purl.obolibrary.org/obo/IAO_0000136) [label](http://www.w3.org/2000/01/rdf-schema#label) "is about"@en +- Class: [hydrolase activity, acting on acid anhydrides](http://purl.obolibrary.org/obo/GO_0016817) -- [is about](http://purl.obolibrary.org/obo/IAO_0000136) [IAO_0000112](http://purl.obolibrary.org/obo/IAO_0000112) "This document is about information artifacts and their representations"@en +- [hydrolase activity, acting on acid anhydrides](http://purl.obolibrary.org/obo/GO_0016817) SubClassOf [hydrolase activity](http://purl.obolibrary.org/obo/GO_0016787) -- ObjectProperty: [is about](http://purl.obolibrary.org/obo/IAO_0000136) -### is active in `http://purl.obolibrary.org/obo/RO_0002432` +### hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides `http://purl.obolibrary.org/obo/GO_0016818` #### Removed -- [is active in](http://purl.obolibrary.org/obo/RO_0002432) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "c executes activity in d if and only if c enables p and p occurs_in d. Assuming no action at a distance by gene products, if a gene product enables (is capable of) a process that occurs in some structure, it must have at least some part in that structure." - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dos" - - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:cjm" +- [hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides](http://purl.obolibrary.org/obo/GO_0016818) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "molecular_function" -#### Added -- [is active in](http://purl.obolibrary.org/obo/RO_0002432) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "c executes activity in d if and only if c enables p and p occurs_in d. Assuming no action at a distance by gene products, if a gene product enables (is capable of) a process that occurs in some structure, it must have at least some part in that structure." - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) [0000-0002-7073-9172](https://orcid.org/0000-0002-7073-9172) +- [hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides](http://purl.obolibrary.org/obo/GO_0016818) [label](http://www.w3.org/2000/01/rdf-schema#label) "hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides" - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) [0000-0002-6601-2165](https://orcid.org/0000-0002-6601-2165) +- [hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides](http://purl.obolibrary.org/obo/GO_0016818) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-9731613" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "NUDT1 hydrolyzes N6-methyl-dATP to N6-methyl-dAMP" -- [is active in](http://purl.obolibrary.org/obo/RO_0002432) [see also](http://www.w3.org/2000/01/rdf-schema#seeAlso) "https://wiki.geneontology.org/Is_active_in"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI) +- [hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides](http://purl.obolibrary.org/obo/GO_0016818) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-9731590" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "NUDT1 hydrolyzes O6-methyl-dGTP to O6-methyl-dGMP" +- [hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides](http://purl.obolibrary.org/obo/GO_0016818) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "EC:3.6.1.-" -### jaw region `http://purl.obolibrary.org/obo/UBERON_0011595` -#### Removed -- [jaw region](http://purl.obolibrary.org/obo/UBERON_0011595) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000) +- [hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides](http://purl.obolibrary.org/obo/GO_0016818) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Catalysis of the hydrolysis of any acid anhydride which contains phosphorus." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:jl" +- [hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides](http://purl.obolibrary.org/obo/GO_0016818) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-9731632" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "NUDT1 hydrolyzes N6-methyl-ATP to N6-methyl-AMP" +- [hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides](http://purl.obolibrary.org/obo/GO_0016818) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0016818" -### jaw skeleton `http://purl.obolibrary.org/obo/UBERON_0001708` -#### Removed -- [jaw skeleton](http://purl.obolibrary.org/obo/UBERON_0001708) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000) +- Class: [hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides](http://purl.obolibrary.org/obo/GO_0016818) +- [hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides](http://purl.obolibrary.org/obo/GO_0016818) SubClassOf [hydrolase activity, acting on acid anhydrides](http://purl.obolibrary.org/obo/GO_0016817) -### jejunum `http://purl.obolibrary.org/obo/UBERON_0002115` -#### Removed -- [jejunum](http://purl.obolibrary.org/obo/UBERON_0002115) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +### import across plasma membrane `http://purl.obolibrary.org/obo/GO_0098739` +#### Added +- [import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098739) [label](http://www.w3.org/2000/01/rdf-schema#label) "import across plasma membrane" -### juxtaglomerular apparatus `http://purl.obolibrary.org/obo/UBERON_0002303` -#### Removed -- [juxtaglomerular apparatus](http://purl.obolibrary.org/obo/UBERON_0002303) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098739) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" +- [import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098739) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The directed movement of some substance from outside of a cell, across the plasma membrane and into the cytosol." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dos" +- [import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098739) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0098739" -### kidney arcuate artery `http://purl.obolibrary.org/obo/UBERON_0001552` -#### Removed -- [kidney arcuate artery](http://purl.obolibrary.org/obo/UBERON_0001552) [depicted by](http://xmlns.com/foaf/0.1/depicted_by) "http://upload.wikimedia.org/wikipedia/commons/e/ee/Gray553.png"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI) +- [import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098739) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "uptake" -#### Added -- [kidney arcuate artery](http://purl.obolibrary.org/obo/UBERON_0001552) [depicted by](http://xmlns.com/foaf/0.1/depicted_by) "https://upload.wikimedia.org/wikipedia/commons/8/87/2610_The_Kidney.jpg"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI) +- Class: [import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098739) +- [import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098739) EquivalentTo [transport](http://purl.obolibrary.org/obo/GO_0006810) and ([has target start location](http://purl.obolibrary.org/obo/RO_0002338) some [extracellular region](http://purl.obolibrary.org/obo/GO_0005576)) and ([has target end location](http://purl.obolibrary.org/obo/RO_0002339) some [cytosol](http://purl.obolibrary.org/obo/GO_0005829)) and ([results in transport across](http://purl.obolibrary.org/obo/RO_0002342) some [plasma membrane](http://purl.obolibrary.org/obo/GO_0005886)) -### kidney interstitium `http://purl.obolibrary.org/obo/UBERON_0005215` -#### Removed -- [kidney interstitium](http://purl.obolibrary.org/obo/UBERON_0005215) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098739) SubClassOf [has target start location](http://purl.obolibrary.org/obo/RO_0002338) some [extracellular region](http://purl.obolibrary.org/obo/GO_0005576) +- [import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098739) SubClassOf [transmembrane transport](http://purl.obolibrary.org/obo/GO_0055085) +- [import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098739) SubClassOf [has target end location](http://purl.obolibrary.org/obo/RO_0002339) some [cytosol](http://purl.obolibrary.org/obo/GO_0005829) -### kidney mesenchyme `http://purl.obolibrary.org/obo/UBERON_0003918` -#### Removed -- [kidney mesenchyme](http://purl.obolibrary.org/obo/UBERON_0003918) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098739) SubClassOf [results in transport across](http://purl.obolibrary.org/obo/RO_0002342) some [plasma membrane](http://purl.obolibrary.org/obo/GO_0005886) +### import into nucleus `http://purl.obolibrary.org/obo/GO_0051170` -### kidney nerve cell `http://purl.obolibrary.org/obo/CL_1000606` -#### Removed -- [kidney nerve cell](http://purl.obolibrary.org/obo/CL_1000606) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +#### Added +- [import into nucleus](http://purl.obolibrary.org/obo/GO_0051170) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "jl" +- [import into nucleus](http://purl.obolibrary.org/obo/GO_0051170) [label](http://www.w3.org/2000/01/rdf-schema#label) "import into nucleus" +- [import into nucleus](http://purl.obolibrary.org/obo/GO_0051170) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" -### kidney rudiment `http://purl.obolibrary.org/obo/UBERON_0005095` -#### Removed -- [kidney rudiment](http://purl.obolibrary.org/obo/UBERON_0005095) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [import into nucleus](http://purl.obolibrary.org/obo/GO_0051170) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0051170" +- [import into nucleus](http://purl.obolibrary.org/obo/GO_0051170) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The directed movement of substances into the nucleus." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:ai" +- [import into nucleus](http://purl.obolibrary.org/obo/GO_0051170) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "nuclear translocation" -### killer cell lectin-like receptor subfamily B member 1 `http://purl.obolibrary.org/obo/PR_000025670` +- [import into nucleus](http://purl.obolibrary.org/obo/GO_0051170) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "nuclear import" -#### Added -- [killer cell lectin-like receptor subfamily B member 1](http://purl.obolibrary.org/obo/PR_000025670) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [killer cell lectin-like receptor subfamily B member 1 (human)](http://purl.obolibrary.org/obo/PR_Q12918) +- [import into nucleus](http://purl.obolibrary.org/obo/GO_0051170) [has_alternative_id](http://www.geneontology.org/formats/oboInOwl#hasAlternativeId) "GO:1902593" +- [import into nucleus](http://purl.obolibrary.org/obo/GO_0051170) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2013-12-19T15:26:34Z" -### killer cell lectin-like receptor subfamily G member 1 `http://purl.obolibrary.org/obo/PR_000009426` +- Class: [import into nucleus](http://purl.obolibrary.org/obo/GO_0051170) -#### Added -- [killer cell lectin-like receptor subfamily G member 1](http://purl.obolibrary.org/obo/PR_000009426) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [killer cell lectin-like receptor subfamily G member 1 (human)](http://purl.obolibrary.org/obo/PR_Q96E93) +- [import into nucleus](http://purl.obolibrary.org/obo/GO_0051170) EquivalentTo [transport](http://purl.obolibrary.org/obo/GO_0006810) and ([has target start location](http://purl.obolibrary.org/obo/RO_0002338) some [cytosol](http://purl.obolibrary.org/obo/GO_0005829)) and ([has target end location](http://purl.obolibrary.org/obo/RO_0002339) some [nuclear lumen](http://purl.obolibrary.org/obo/GO_0031981)) and ([results in transport across](http://purl.obolibrary.org/obo/RO_0002342) some [nuclear envelope](http://purl.obolibrary.org/obo/GO_0005635)) +- [import into nucleus](http://purl.obolibrary.org/obo/GO_0051170) SubClassOf [has target end location](http://purl.obolibrary.org/obo/RO_0002339) some [nuclear lumen](http://purl.obolibrary.org/obo/GO_0031981) -### knee joint `http://purl.obolibrary.org/obo/UBERON_0001485` -#### Removed -- [knee joint](http://purl.obolibrary.org/obo/UBERON_0001485) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [import into nucleus](http://purl.obolibrary.org/obo/GO_0051170) SubClassOf [has target start location](http://purl.obolibrary.org/obo/RO_0002338) some [cytosol](http://purl.obolibrary.org/obo/GO_0005829) +- [import into nucleus](http://purl.obolibrary.org/obo/GO_0051170) SubClassOf [nucleocytoplasmic transport](http://purl.obolibrary.org/obo/GO_0006913) -### koniocellular cell `http://purl.obolibrary.org/obo/CL_4023187` +### indoleamine-accumulating amacrine cell `http://purl.obolibrary.org/obo/CL_0004245` #### Removed -- [koniocellular cell](http://purl.obolibrary.org/obo/CL_4023187) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [indoleamine-accumulating amacrine cell](http://purl.obolibrary.org/obo/CL_0004245) SubClassOf [retina horizontal cell](http://purl.obolibrary.org/obo/CL_0000745) -### lacrimal apparatus `http://purl.obolibrary.org/obo/UBERON_0001750` +### information content entity `http://purl.obolibrary.org/obo/IAO_0000030` #### Removed -- [lacrimal apparatus](http://purl.obolibrary.org/obo/UBERON_0001750) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [information content entity](http://purl.obolibrary.org/obo/IAO_0000030) [IAO_0000117](http://purl.obolibrary.org/obo/IAO_0000117) "PERSON: Chris Stoeckert"@en +- [information content entity](http://purl.obolibrary.org/obo/IAO_0000030) [IAO_0000114](http://purl.obolibrary.org/obo/IAO_0000114) [ready for release](http://purl.obolibrary.org/obo/IAO_0000122) +- [information content entity](http://purl.obolibrary.org/obo/IAO_0000030) [label](http://www.w3.org/2000/01/rdf-schema#label) "information content entity"@en -### lacrimal nerve `http://purl.obolibrary.org/obo/UBERON_0011096` -#### Removed -- [lacrimal nerve](http://purl.obolibrary.org/obo/UBERON_0011096) SubClassOf [neuron projection bundle](http://purl.obolibrary.org/obo/CARO_0001001) +- [information content entity](http://purl.obolibrary.org/obo/IAO_0000030) [IAO_0000119](http://purl.obolibrary.org/obo/IAO_0000119) "OBI_0000142"@en +- [information content entity](http://purl.obolibrary.org/obo/IAO_0000030) [editor note](http://purl.obolibrary.org/obo/IAO_0000116) "information_content_entity 'is_encoded_in' some digital_entity in obi before split (040907). information_content_entity 'is_encoded_in' some physical_document in obi before split (040907). +Previous. An information content entity is a non-realizable information entity that 'is encoded in' some digital or physical entity."@en -### lactosylceramide 4-alpha-galactosyltransferase `http://purl.obolibrary.org/obo/PR_000003516` +- [information content entity](http://purl.obolibrary.org/obo/IAO_0000030) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A generically dependent continuant that is about some thing."@en -#### Added -- [lactosylceramide 4-alpha-galactosyltransferase](http://purl.obolibrary.org/obo/PR_000003516) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [lactosylceramide 4-alpha-galactosyltransferase (human)](http://purl.obolibrary.org/obo/PR_Q9NPC4) +- [information content entity](http://purl.obolibrary.org/obo/IAO_0000030) [IAO_0000112](http://purl.obolibrary.org/obo/IAO_0000112) "Examples of information content entites include journal articles, data, graphical layouts, and graphs."@en +- [information content entity](http://purl.obolibrary.org/obo/IAO_0000030) [editor note](http://purl.obolibrary.org/obo/IAO_0000116) "2014-03-10: The use of "thing" is intended to be general enough to include universals and configurations (see https://groups.google.com/d/msg/information-ontology/GBxvYZCk1oc/-L6B5fSBBTQJ)."@en -### lactotransferrin `http://purl.obolibrary.org/obo/PR_000009978` +- [information content entity](http://purl.obolibrary.org/obo/IAO_0000030) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "information content entity"@en -#### Added -- [lactotransferrin](http://purl.obolibrary.org/obo/PR_000009978) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [lactotransferrin (human)](http://purl.obolibrary.org/obo/PR_P02788) +- Class: [information content entity](http://purl.obolibrary.org/obo/IAO_0000030) +- [information content entity](http://purl.obolibrary.org/obo/IAO_0000030) SubClassOf [is about](http://purl.obolibrary.org/obo/IAO_0000136) some [BFO_0000001](http://purl.obolibrary.org/obo/BFO_0000001) -### lamp5 GABAergic cortical interneuron `http://purl.obolibrary.org/obo/CL_4023011` +- [information content entity](http://purl.obolibrary.org/obo/IAO_0000030) SubClassOf [generically dependent continuant](http://purl.obolibrary.org/obo/BFO_0000031) -#### Added -- [lamp5 GABAergic cortical interneuron](http://purl.obolibrary.org/obo/CL_4023011) [symbol](http://purl.obolibrary.org/obo/IAO_0000028) "Lamp5 cortical interneuron" -### laryngeal apparatus `http://purl.obolibrary.org/obo/UBERON_0010212` -#### Removed -- [laryngeal apparatus](http://purl.obolibrary.org/obo/UBERON_0010212) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +### intercellular bridge `http://purl.obolibrary.org/obo/GO_0045171` +#### Added +- [intercellular bridge](http://purl.obolibrary.org/obo/GO_0045171) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0045171" +- [intercellular bridge](http://purl.obolibrary.org/obo/GO_0045171) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A direct connection between the cytoplasm of two cells that is formed following the completion of cleavage furrow ingression during cell division. They are usually present only briefly prior to completion of cytokinesis. However, in some cases, such as the bridges between germ cells during their development, they become stabilised." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:9635420" -### laryngeal nerve `http://purl.obolibrary.org/obo/UBERON_0035642` -#### Removed -- [laryngeal nerve](http://purl.obolibrary.org/obo/UBERON_0035642) SubClassOf [neuron projection bundle](http://purl.obolibrary.org/obo/CARO_0001001) +- [intercellular bridge](http://purl.obolibrary.org/obo/GO_0045171) [label](http://www.w3.org/2000/01/rdf-schema#label) "intercellular bridge" +- [intercellular bridge](http://purl.obolibrary.org/obo/GO_0045171) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "cellular_component" +- Class: [intercellular bridge](http://purl.obolibrary.org/obo/GO_0045171) -### larynx `http://purl.obolibrary.org/obo/UBERON_0001737` -#### Removed -- [larynx](http://purl.obolibrary.org/obo/UBERON_0001737) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000) +- [intercellular bridge](http://purl.obolibrary.org/obo/GO_0045171) SubClassOf [cellular anatomical entity](http://purl.obolibrary.org/obo/GO_0110165) +### intercellular bridge organization `http://purl.obolibrary.org/obo/GO_0043063` -### lateral line ganglion neuron `http://purl.obolibrary.org/obo/CL_2000031` -#### Removed -- [lateral line ganglion neuron](http://purl.obolibrary.org/obo/CL_2000031) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +#### Added +- [intercellular bridge organization](http://purl.obolibrary.org/obo/GO_0043063) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" +- [intercellular bridge organization](http://purl.obolibrary.org/obo/GO_0043063) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the intracellular bridge. An intracellular bridge is a direct link between the cytoplasms of sister cells that allows cells to communicate with one another." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:jid" +- [intercellular bridge organization](http://purl.obolibrary.org/obo/GO_0043063) [label](http://www.w3.org/2000/01/rdf-schema#label) "intercellular bridge organization" -### lateral line system `http://purl.obolibrary.org/obo/UBERON_0002540` -#### Removed -- [lateral line system](http://purl.obolibrary.org/obo/UBERON_0002540) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [intercellular bridge organization](http://purl.obolibrary.org/obo/GO_0043063) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "intercellular bridge organization and biogenesis" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:mah" +- [intercellular bridge organization](http://purl.obolibrary.org/obo/GO_0043063) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "intercellular bridge organisation" +- [intercellular bridge organization](http://purl.obolibrary.org/obo/GO_0043063) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0043063" -### lateral lingual swelling `http://purl.obolibrary.org/obo/UBERON_0006757` -#### Removed -- [lateral lingual swelling](http://purl.obolibrary.org/obo/UBERON_0006757) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- Class: [intercellular bridge organization](http://purl.obolibrary.org/obo/GO_0043063) +- [intercellular bridge organization](http://purl.obolibrary.org/obo/GO_0043063) EquivalentTo [cellular component organization](http://purl.obolibrary.org/obo/GO_0016043) and ([results in organization of](http://purl.obolibrary.org/obo/RO_0002592) some [intercellular bridge](http://purl.obolibrary.org/obo/GO_0045171)) +- [intercellular bridge organization](http://purl.obolibrary.org/obo/GO_0043063) SubClassOf [extracellular structure organization](http://purl.obolibrary.org/obo/GO_0043062) -### lateral nasal prominence `http://purl.obolibrary.org/obo/UBERON_0004067` -#### Removed -- [lateral nasal prominence](http://purl.obolibrary.org/obo/UBERON_0004067) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [intercellular bridge organization](http://purl.obolibrary.org/obo/GO_0043063) SubClassOf [results in organization of](http://purl.obolibrary.org/obo/RO_0002592) some [intercellular bridge](http://purl.obolibrary.org/obo/GO_0045171) +### intracellular ligand-gated monoatomic ion channel activity `http://purl.obolibrary.org/obo/GO_0005217` -### lateral ventricle neuron `http://purl.obolibrary.org/obo/CL_1001582` -#### Removed -- [lateral ventricle neuron](http://purl.obolibrary.org/obo/CL_1001582) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +#### Added +- [intracellular ligand-gated monoatomic ion channel activity](http://purl.obolibrary.org/obo/GO_0005217) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "intracellular ligand-gated ion channel activity" +- [intracellular ligand-gated monoatomic ion channel activity](http://purl.obolibrary.org/obo/GO_0005217) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0005217" +- [intracellular ligand-gated monoatomic ion channel activity](http://purl.obolibrary.org/obo/GO_0005217) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Enables the transmembrane transfer of an ion by a channel that opens when a specific intracellular ligand has been bound by the channel complex or one of its constituent parts." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ISBN:0815340729" -### layer of muscle tissue `http://purl.obolibrary.org/obo/UBERON_0018260` -#### Removed -- [layer of muscle tissue](http://purl.obolibrary.org/obo/UBERON_0018260) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:mtg_transport" +- [intracellular ligand-gated monoatomic ion channel activity](http://purl.obolibrary.org/obo/GO_0005217) [label](http://www.w3.org/2000/01/rdf-schema#label) "intracellular ligand-gated monoatomic ion channel activity" +- [intracellular ligand-gated monoatomic ion channel activity](http://purl.obolibrary.org/obo/GO_0005217) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "molecular_function" -### lens of camera-type eye `http://purl.obolibrary.org/obo/UBERON_0000965` -#### Removed -- [lens of camera-type eye](http://purl.obolibrary.org/obo/UBERON_0000965) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- Class: [intracellular ligand-gated monoatomic ion channel activity](http://purl.obolibrary.org/obo/GO_0005217) +- [intracellular ligand-gated monoatomic ion channel activity](http://purl.obolibrary.org/obo/GO_0005217) SubClassOf [ligand-gated monoatomic ion channel activity](http://purl.obolibrary.org/obo/GO_0015276) -### lens placode `http://purl.obolibrary.org/obo/UBERON_0003073` -#### Removed -- [lens placode](http://purl.obolibrary.org/obo/UBERON_0003073) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +### iron ion export across plasma membrane `http://purl.obolibrary.org/obo/GO_1903988` +#### Added +- [iron ion export across plasma membrane](http://purl.obolibrary.org/obo/GO_1903988) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:1903988" +- [iron ion export across plasma membrane](http://purl.obolibrary.org/obo/GO_1903988) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "ferrous iron export" -### lens vesicle `http://purl.obolibrary.org/obo/UBERON_0005426` -#### Removed -- [lens vesicle](http://purl.obolibrary.org/obo/UBERON_0005426) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [iron ion export across plasma membrane](http://purl.obolibrary.org/obo/GO_1903988) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2014-09-03T13:01:37Z" +- [iron ion export across plasma membrane](http://purl.obolibrary.org/obo/GO_1903988) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" +- [iron ion export across plasma membrane](http://purl.obolibrary.org/obo/GO_1903988) [label](http://www.w3.org/2000/01/rdf-schema#label) "iron ion export across plasma membrane" -### leucophore `http://purl.obolibrary.org/obo/CL_0000571` -#### Removed -- [leucophore](http://purl.obolibrary.org/obo/CL_0000571) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [iron ion export across plasma membrane](http://purl.obolibrary.org/obo/GO_1903988) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "ferrous iron export across plasma membrane" +- [iron ion export across plasma membrane](http://purl.obolibrary.org/obo/GO_1903988) [has_alternative_id](http://www.geneontology.org/formats/oboInOwl#hasAlternativeId) "GO:1903414" +- [iron ion export across plasma membrane](http://purl.obolibrary.org/obo/GO_1903988) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The directed movement of iron ions from inside of a cell, across the plasma membrane and into the extracellular region." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:15514116" -### leukocyte `http://purl.obolibrary.org/obo/CL_0000738` -#### Removed -- [leukocyte](http://purl.obolibrary.org/obo/CL_0000738) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:kom" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:rl" -### leukocyte immunoglobulin-like receptor subfamily A member 4 `http://purl.obolibrary.org/obo/PR_000001398` + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:BHF" -#### Added -- [leukocyte immunoglobulin-like receptor subfamily A member 4](http://purl.obolibrary.org/obo/PR_000001398) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [leukocyte immunoglobulin-like receptor subfamily A member 4 (human)](http://purl.obolibrary.org/obo/PR_P59901) + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GO_REF:0000074" +- [iron ion export across plasma membrane](http://purl.obolibrary.org/obo/GO_1903988) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "iron(2+) export" -### leukosialin `http://purl.obolibrary.org/obo/PR_000001879` +- [iron ion export across plasma membrane](http://purl.obolibrary.org/obo/GO_1903988) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "iron cation export" -#### Added -- [leukosialin](http://purl.obolibrary.org/obo/PR_000001879) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [leukosialin (human)](http://purl.obolibrary.org/obo/PR_P16150) +- [iron ion export across plasma membrane](http://purl.obolibrary.org/obo/GO_1903988) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "rl" +- [iron ion export across plasma membrane](http://purl.obolibrary.org/obo/GO_1903988) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "An example of this is mouse ferroportin (symbol Slc40a1, UniProtKB identifier: Q9JHI9)." -### limb connective tissue `http://purl.obolibrary.org/obo/UBERON_0003587` -#### Removed -- [limb connective tissue](http://purl.obolibrary.org/obo/UBERON_0003587) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- Class: [iron ion export across plasma membrane](http://purl.obolibrary.org/obo/GO_1903988) +- [iron ion export across plasma membrane](http://purl.obolibrary.org/obo/GO_1903988) EquivalentTo [transport](http://purl.obolibrary.org/obo/GO_0006810) and ([has target start location](http://purl.obolibrary.org/obo/RO_0002338) some [cytosol](http://purl.obolibrary.org/obo/GO_0005829)) and ([has target end location](http://purl.obolibrary.org/obo/RO_0002339) some [extracellular region](http://purl.obolibrary.org/obo/GO_0005576)) and ([results in transport across](http://purl.obolibrary.org/obo/RO_0002342) some [plasma membrane](http://purl.obolibrary.org/obo/GO_0005886)) and ([has primary input](http://purl.obolibrary.org/obo/RO_0004009) some [CHEBI_24875](http://purl.obolibrary.org/obo/CHEBI_24875)) +- [iron ion export across plasma membrane](http://purl.obolibrary.org/obo/GO_1903988) SubClassOf [export across plasma membrane](http://purl.obolibrary.org/obo/GO_0140115) -### limb segment `http://purl.obolibrary.org/obo/UBERON_0002529` -#### Removed -- [limb segment](http://purl.obolibrary.org/obo/UBERON_0002529) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [iron ion export across plasma membrane](http://purl.obolibrary.org/obo/GO_1903988) SubClassOf [iron ion transmembrane transport](http://purl.obolibrary.org/obo/GO_0034755) +### iron ion import across plasma membrane `http://purl.obolibrary.org/obo/GO_0098711` -### lingual nerve `http://purl.obolibrary.org/obo/UBERON_0003721` -#### Removed -- [lingual nerve](http://purl.obolibrary.org/obo/UBERON_0003721) SubClassOf [neuron projection bundle](http://purl.obolibrary.org/obo/CARO_0001001) +#### Added +- [iron ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098711) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The directed movement of iron ions from outside of a cell, across the plasma membrane and into the cytosol." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:8321236" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:mah" +- [iron ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098711) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "ferrous iron import across plasma membrane" -### lingual swellings `http://purl.obolibrary.org/obo/UBERON_0006260` -#### Removed -- [lingual swellings](http://purl.obolibrary.org/obo/UBERON_0006260) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [iron ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098711) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "ferrous ion import into cell" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:mah" +- [iron ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098711) [has_alternative_id](http://www.geneontology.org/formats/oboInOwl#hasAlternativeId) "GO:0098707" +- [iron ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098711) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" -### liver lobule `http://purl.obolibrary.org/obo/UBERON_0004647` -#### Removed -- [liver lobule](http://purl.obolibrary.org/obo/UBERON_0004647) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [iron ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098711) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0098711" +- [iron ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098711) [label](http://www.w3.org/2000/01/rdf-schema#label) "iron ion import across plasma membrane" +- [iron ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098711) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2012-12-20T08:29:00Z" -### lobar bronchus `http://purl.obolibrary.org/obo/UBERON_0002183` +- [iron ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098711) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "pr" -#### Added -- [lobar bronchus](http://purl.obolibrary.org/obo/UBERON_0002183) SubClassOf [has part](http://purl.obolibrary.org/obo/BFO_0000051) some [bronchus smooth muscle](http://purl.obolibrary.org/obo/UBERON_0004242) +- [iron ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098711) [has_alternative_id](http://www.geneontology.org/formats/oboInOwl#hasAlternativeId) "GO:0097459" -- [lobar bronchus](http://purl.obolibrary.org/obo/UBERON_0002183) SubClassOf [has part](http://purl.obolibrary.org/obo/BFO_0000051) some [cartilage of bronchus](http://purl.obolibrary.org/obo/UBERON_0001956) +- [iron ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098711) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "ferrous iron import into cell" -- [lobar bronchus](http://purl.obolibrary.org/obo/UBERON_0002183) SubClassOf [has part](http://purl.obolibrary.org/obo/BFO_0000051) some [bronchus submucosal gland](http://purl.obolibrary.org/obo/UBERON_8410043) +- [iron ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098711) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "iron ion import into cell" +- [iron ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098711) [has_alternative_id](http://www.geneontology.org/formats/oboInOwl#hasAlternativeId) "GO:0097460" -### located in `http://purl.obolibrary.org/obo/RO_0001025` +- [iron ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098711) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "iron import into cell" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:mah" -#### Added -- [located in](http://purl.obolibrary.org/obo/RO_0001025) [see also](http://www.w3.org/2000/01/rdf-schema#seeAlso) "https://wiki.geneontology.org/Located_in"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI) +- Class: [iron ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098711) +- [iron ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098711) EquivalentTo [transport](http://purl.obolibrary.org/obo/GO_0006810) and ([has target start location](http://purl.obolibrary.org/obo/RO_0002338) some [extracellular region](http://purl.obolibrary.org/obo/GO_0005576)) and ([has target end location](http://purl.obolibrary.org/obo/RO_0002339) some [cytosol](http://purl.obolibrary.org/obo/GO_0005829)) and ([results in transport across](http://purl.obolibrary.org/obo/RO_0002342) some [plasma membrane](http://purl.obolibrary.org/obo/GO_0005886)) and ([has primary input](http://purl.obolibrary.org/obo/RO_0004009) some [CHEBI_24875](http://purl.obolibrary.org/obo/CHEBI_24875)) -### long-wave-sensitive opsin 1 `http://purl.obolibrary.org/obo/PR_000001244` +- [iron ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098711) SubClassOf [iron ion transmembrane transport](http://purl.obolibrary.org/obo/GO_0034755) -#### Added -- [long-wave-sensitive opsin 1](http://purl.obolibrary.org/obo/PR_000001244) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [long-wave-sensitive opsin 1 (human)](http://purl.obolibrary.org/obo/PR_P04000) +- [iron ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098711) SubClassOf [import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098739) + +- [iron ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098711) SubClassOf [iron import into cell](http://purl.obolibrary.org/obo/GO_0033212) -### loose mesenchyme tissue `http://purl.obolibrary.org/obo/UBERON_0007529` +### is about `http://purl.obolibrary.org/obo/IAO_0000136` #### Removed -- [loose mesenchyme tissue](http://purl.obolibrary.org/obo/UBERON_0007529) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [is about](http://purl.obolibrary.org/obo/IAO_0000136) [IAO_0000112](http://purl.obolibrary.org/obo/IAO_0000112) "This document is about information artifacts and their representations"@en +- [is about](http://purl.obolibrary.org/obo/IAO_0000136) [IAO_0000114](http://purl.obolibrary.org/obo/IAO_0000114) [pending final vetting](http://purl.obolibrary.org/obo/IAO_0000125) +- [is about](http://purl.obolibrary.org/obo/IAO_0000136) [editor note](http://purl.obolibrary.org/obo/IAO_0000116) "7/6/2009 Alan Ruttenberg. Following discussion with Jonathan Rees, and introduction of "mentions" relation. Weaken the is_about relationship to be primitive. -### low affinity immunoglobulin epsilon Fc receptor `http://purl.obolibrary.org/obo/PR_000001880` +We will try to build it back up by elaborating the various subproperties that are more precisely defined. -#### Added -- [low affinity immunoglobulin epsilon Fc receptor](http://purl.obolibrary.org/obo/PR_000001880) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [low affinity immunoglobulin epsilon Fc receptor (human)](http://purl.obolibrary.org/obo/PR_P06734) +Some currently missing phenomena that should be considered "about" are predications - "The only person who knows the answer is sitting beside me" , Allegory, Satire, and other literary forms that can be topical without explicitly mentioning the topic."@en +- [is about](http://purl.obolibrary.org/obo/IAO_0000136) [IAO_0000117](http://purl.obolibrary.org/obo/IAO_0000117) "person:Alan Ruttenberg"@en -### low affinity immunoglobulin gamma Fc region receptor II-b `http://purl.obolibrary.org/obo/PR_000001481` +- [is about](http://purl.obolibrary.org/obo/IAO_0000136) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A (currently) primitive relation that relates an information artifact to an entity."@en -#### Added -- [low affinity immunoglobulin gamma Fc region receptor II-b](http://purl.obolibrary.org/obo/PR_000001481) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [low affinity immunoglobulin gamma Fc region receptor II-b (human)](http://purl.obolibrary.org/obo/PR_P31994) +- [is about](http://purl.obolibrary.org/obo/IAO_0000136) [label](http://www.w3.org/2000/01/rdf-schema#label) "is about"@en +- [is about](http://purl.obolibrary.org/obo/IAO_0000136) [IAO_0000119](http://purl.obolibrary.org/obo/IAO_0000119) "Smith, Ceusters, Ruttenberg, 2000 years of philosophy"@en -### lower digestive tract `http://purl.obolibrary.org/obo/UBERON_0004907` -#### Removed -- [lower digestive tract](http://purl.obolibrary.org/obo/UBERON_0004907) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- ObjectProperty: [is about](http://purl.obolibrary.org/obo/IAO_0000136) -### lower jaw region `http://purl.obolibrary.org/obo/UBERON_0001710` +### lateral line nerve glial cell morphogenesis involved in differentiation `http://purl.obolibrary.org/obo/GO_0048938` #### Removed -- [lower jaw region](http://purl.obolibrary.org/obo/UBERON_0001710) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000) +- [lateral line nerve glial cell morphogenesis involved in differentiation](http://purl.obolibrary.org/obo/GO_0048938) EquivalentTo [cell morphogenesis involved in differentiation](http://purl.obolibrary.org/obo/GO_0000904) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [lateral line nerve glial cell development](http://purl.obolibrary.org/obo/GO_0048937)) + +- [lateral line nerve glial cell morphogenesis involved in differentiation](http://purl.obolibrary.org/obo/GO_0048938) SubClassOf [cell morphogenesis involved in differentiation](http://purl.obolibrary.org/obo/GO_0000904) + +#### Added +- [lateral line nerve glial cell morphogenesis involved in differentiation](http://purl.obolibrary.org/obo/GO_0048938) EquivalentTo [cell morphogenesis](http://purl.obolibrary.org/obo/GO_0000902) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [lateral line nerve glial cell development](http://purl.obolibrary.org/obo/GO_0048937)) +- [lateral line nerve glial cell morphogenesis involved in differentiation](http://purl.obolibrary.org/obo/GO_0048938) SubClassOf [cell morphogenesis](http://purl.obolibrary.org/obo/GO_0000902) -### lower leg epithelium `http://purl.obolibrary.org/obo/UBERON_0005229` +### leptomeningeal cell `http://purl.obolibrary.org/obo/CL_0000708` #### Removed -- [lower leg epithelium](http://purl.obolibrary.org/obo/UBERON_0005229) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [leptomeningeal cell](http://purl.obolibrary.org/obo/CL_0000708) SubClassOf [choroid plexus cell](http://purl.obolibrary.org/obo/CL_4023073) -### lower lip `http://purl.obolibrary.org/obo/UBERON_0001835` +### ligase activity `http://purl.obolibrary.org/obo/GO_0016874` #### Removed -- [lower lip](http://purl.obolibrary.org/obo/UBERON_0001835) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [ligase activity](http://purl.obolibrary.org/obo/GO_0016874) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [goslim_candida](http://purl.obolibrary.org/obo/go#goslim_candida) +- [ligase activity](http://purl.obolibrary.org/obo/GO_0016874) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [goslim_pir](http://purl.obolibrary.org/obo/go#goslim_pir) +- [ligase activity](http://purl.obolibrary.org/obo/GO_0016874) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [goslim_yeast](http://purl.obolibrary.org/obo/go#goslim_yeast) -### lower motor neuron `http://purl.obolibrary.org/obo/CL_0008039` -#### Removed -- [lower motor neuron](http://purl.obolibrary.org/obo/CL_0008039) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [ligase activity](http://purl.obolibrary.org/obo/GO_0016874) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [goslim_drosophila](http://purl.obolibrary.org/obo/go#goslim_drosophila) +- [ligase activity](http://purl.obolibrary.org/obo/GO_0016874) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [goslim_metagenomics](http://purl.obolibrary.org/obo/go#goslim_metagenomics) +- [ligase activity](http://purl.obolibrary.org/obo/GO_0016874) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [goslim_mouse](http://purl.obolibrary.org/obo/go#goslim_mouse) -### lower respiratory tract `http://purl.obolibrary.org/obo/UBERON_0001558` -#### Removed -- [lower respiratory tract](http://purl.obolibrary.org/obo/UBERON_0001558) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [ligase activity](http://purl.obolibrary.org/obo/GO_0016874) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "synthetase activity" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:jh2" +- [ligase activity](http://purl.obolibrary.org/obo/GO_0016874) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "molecular_function" +- [ligase activity](http://purl.obolibrary.org/obo/GO_0016874) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Catalysis of the joining of two molecules, or two groups within a single molecule, using the energy from the hydrolysis of ATP, a similar triphosphate, or a pH gradient." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:mah" -### lower urinary tract `http://purl.obolibrary.org/obo/UBERON_0001556` -#### Removed -- [lower urinary tract](http://purl.obolibrary.org/obo/UBERON_0001556) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [ligase activity](http://purl.obolibrary.org/obo/GO_0016874) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "EC:6.-.-.-" +- [ligase activity](http://purl.obolibrary.org/obo/GO_0016874) [term tracker item](http://purl.obolibrary.org/obo/IAO_0000233) "https://github.com/geneontology/go-ontology/issues/19380"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI) +- [ligase activity](http://purl.obolibrary.org/obo/GO_0016874) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [goslim_generic](http://purl.obolibrary.org/obo/go#goslim_generic) -### lumbosacral nerve plexus `http://purl.obolibrary.org/obo/UBERON_0001815` -#### Removed -- [lumbosacral nerve plexus](http://purl.obolibrary.org/obo/UBERON_0001815) SubClassOf [neuron projection bundle](http://purl.obolibrary.org/obo/CARO_0001001) +- [ligase activity](http://purl.obolibrary.org/obo/GO_0016874) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [prokaryote_subset](http://purl.obolibrary.org/obo/go#prokaryote_subset) -#### Added -- [lumbosacral nerve plexus](http://purl.obolibrary.org/obo/UBERON_0001815) SubClassOf [neuron projection bundle](http://purl.obolibrary.org/obo/UBERON_0000122) +- [ligase activity](http://purl.obolibrary.org/obo/GO_0016874) [label](http://www.w3.org/2000/01/rdf-schema#label) "ligase activity" +- [ligase activity](http://purl.obolibrary.org/obo/GO_0016874) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0016874" -### lumen of `http://purl.obolibrary.org/obo/RO_0002571` -#### Removed -- [lumen of](http://purl.obolibrary.org/obo/RO_0002571) [IAO_0000119](http://purl.obolibrary.org/obo/IAO_0000119) "GOC:cjm" +- [ligase activity](http://purl.obolibrary.org/obo/GO_0016874) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [goslim_chembl](http://purl.obolibrary.org/obo/go#goslim_chembl) -#### Added -- [lumen of](http://purl.obolibrary.org/obo/RO_0002571) [IAO_0000119](http://purl.obolibrary.org/obo/IAO_0000119) [0000-0002-6601-2165](https://orcid.org/0000-0002-6601-2165) +- Class: [ligase activity](http://purl.obolibrary.org/obo/GO_0016874) + +- [ligase activity](http://purl.obolibrary.org/obo/GO_0016874) SubClassOf [catalytic activity](http://purl.obolibrary.org/obo/GO_0003824) -### lumen of central canal of spinal cord `http://purl.obolibrary.org/obo/UBERON_0009572` + +### ligase activity, forming carbon-sulfur bonds `http://purl.obolibrary.org/obo/GO_0016877` #### Removed -- [lumen of central canal of spinal cord](http://purl.obolibrary.org/obo/UBERON_0009572) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [ligase activity, forming carbon-sulfur bonds](http://purl.obolibrary.org/obo/GO_0016877) [label](http://www.w3.org/2000/01/rdf-schema#label) "ligase activity, forming carbon-sulfur bonds" +- [ligase activity, forming carbon-sulfur bonds](http://purl.obolibrary.org/obo/GO_0016877) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "ligase activity, forming carbon-sulphur bonds" +- [ligase activity, forming carbon-sulfur bonds](http://purl.obolibrary.org/obo/GO_0016877) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Catalysis of the joining of two molecules via a carbon-sulfur bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "EC:6.2.-.-" -### lumican `http://purl.obolibrary.org/obo/PR_000009981` + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:mah" -#### Added -- [lumican](http://purl.obolibrary.org/obo/PR_000009981) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [lumican (human)](http://purl.obolibrary.org/obo/PR_P51884) +- [ligase activity, forming carbon-sulfur bonds](http://purl.obolibrary.org/obo/GO_0016877) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "EC:6.2.-.-" +- [ligase activity, forming carbon-sulfur bonds](http://purl.obolibrary.org/obo/GO_0016877) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0016877" -### luminal epithelial cell of mammary gland `http://purl.obolibrary.org/obo/CL_0002326` -#### Removed -- [luminal epithelial cell of mammary gland](http://purl.obolibrary.org/obo/CL_0002326) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [ligase activity, forming carbon-sulfur bonds](http://purl.obolibrary.org/obo/GO_0016877) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "molecular_function" +- Class: [ligase activity, forming carbon-sulfur bonds](http://purl.obolibrary.org/obo/GO_0016877) +- [ligase activity, forming carbon-sulfur bonds](http://purl.obolibrary.org/obo/GO_0016877) SubClassOf [ligase activity](http://purl.obolibrary.org/obo/GO_0016874) -### lung bud `http://purl.obolibrary.org/obo/UBERON_0000118` -#### Removed -- [lung bud](http://purl.obolibrary.org/obo/UBERON_0000118) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +### lobar bronchus mesenchyme `http://purl.obolibrary.org/obo/UBERON_0004884` -### lung epithelium `http://purl.obolibrary.org/obo/UBERON_0000115` -#### Removed -- [lung epithelium](http://purl.obolibrary.org/obo/UBERON_0000115) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +#### Added +- [lobar bronchus mesenchyme](http://purl.obolibrary.org/obo/UBERON_0004884) [contributor](http://purl.org/dc/terms/contributor) [0000-0001-6677-8489](https://orcid.org/0000-0001-6677-8489) +- [lobar bronchus mesenchyme](http://purl.obolibrary.org/obo/UBERON_0004884) SubClassOf [has part](http://purl.obolibrary.org/obo/BFO_0000051) some [tracheobronchial smooth muscle cell](http://purl.obolibrary.org/obo/CL_0019019) -### lung field `http://purl.obolibrary.org/obo/UBERON_0022361` +### located in `http://purl.obolibrary.org/obo/RO_0001025` #### Removed -- [lung field](http://purl.obolibrary.org/obo/UBERON_0022361) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [located in](http://purl.obolibrary.org/obo/RO_0001025) [source](http://purl.org/dc/elements/1.1/source) "http://www.obofoundry.org/ro/#OBO_REL:located_in" +#### Added +- [located in](http://purl.obolibrary.org/obo/RO_0001025) [source](http://purl.org/dc/terms/source) "http://www.obofoundry.org/ro/#OBO_REL:located_in" -### lung megakaryocyte `http://purl.obolibrary.org/obo/CL_4033018` +### lung neuroendocrine cell `http://purl.obolibrary.org/obo/CL_1000223` #### Added -- [lung megakaryocyte](http://purl.obolibrary.org/obo/CL_4033018) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "lung-resident megakaryocyte" - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:36524131" - -- [lung megakaryocyte](http://purl.obolibrary.org/obo/CL_4033018) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "lung resident megakaryocyte" - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:36524131" - -- [lung megakaryocyte](http://purl.obolibrary.org/obo/CL_4033018) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "MKL" +- [lung neuroendocrine cell](http://purl.obolibrary.org/obo/CL_1000223) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "PNEC" - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation) - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:36524131" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:33355253" -- [lung megakaryocyte](http://purl.obolibrary.org/obo/CL_4033018) EquivalentTo [megakaryocyte](http://purl.obolibrary.org/obo/CL_0000556) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [lung connective tissue](http://purl.obolibrary.org/obo/UBERON_0000114)) +- [lung neuroendocrine cell](http://purl.obolibrary.org/obo/CL_1000223) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "pulmonary neuroendocrine cell" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:33355253" -- [lung megakaryocyte](http://purl.obolibrary.org/obo/CL_4033018) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [lung connective tissue](http://purl.obolibrary.org/obo/UBERON_0000114) +- [lung neuroendocrine cell](http://purl.obolibrary.org/obo/CL_1000223) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A neuroendocrine cell that is part of respiratory epithelium of the lung and is involved in the sensory detection of environmental stimuli, including hypoxia, nicotine and air pressure. Ultrastructurally, this cell type is characterized by the presence of cytoplasmic dense core granules, which are considered the storage sites of amine and peptide hormones. Lung neuroendocrine cells are innervated and appear as solitary cells or as clustered masses, localized at airway bifurcation sites, called neuroepithelial bodies that can release serotonin in response to hypoxia and interact with sensory nerve terminals. Lung neuroendocrine cells also function as reserve stem cells that repair the surrounding epithelium after injury." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:33355253" -- [lung megakaryocyte](http://purl.obolibrary.org/obo/CL_4033018) SubClassOf [connective tissue cell](http://purl.obolibrary.org/obo/CL_0002320) + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.3109/01902148209069653" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.7554/eLife.78216" -### lung primordium `http://purl.obolibrary.org/obo/UBERON_0005597` -#### Removed -- [lung primordium](http://purl.obolibrary.org/obo/UBERON_0005597) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [lung neuroendocrine cell](http://purl.obolibrary.org/obo/CL_1000223) SubClassOf [serotonin secreting cell](http://purl.obolibrary.org/obo/CL_0000458) +- [lung neuroendocrine cell](http://purl.obolibrary.org/obo/CL_1000223) SubClassOf [capable of](http://purl.obolibrary.org/obo/RO_0002215) some [detection of hypoxia](http://purl.obolibrary.org/obo/GO_0070483) +- [lung neuroendocrine cell](http://purl.obolibrary.org/obo/CL_1000223) SubClassOf [has part](http://purl.obolibrary.org/obo/BFO_0000051) some [dense core granule](http://purl.obolibrary.org/obo/GO_0031045) -### lymph `http://purl.obolibrary.org/obo/UBERON_0002391` -#### Removed -- [lymph](http://purl.obolibrary.org/obo/UBERON_0002391) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [lung neuroendocrine cell](http://purl.obolibrary.org/obo/CL_1000223) SubClassOf [chemoreceptor cell](http://purl.obolibrary.org/obo/CL_0000206) +- [lung neuroendocrine cell](http://purl.obolibrary.org/obo/CL_1000223) SubClassOf [neuronal receptor cell](http://purl.obolibrary.org/obo/CL_0000006) +- [lung neuroendocrine cell](http://purl.obolibrary.org/obo/CL_1000223) SubClassOf [sensory epithelial cell](http://purl.obolibrary.org/obo/CL_0000098) -### lymph node macrophage `http://purl.obolibrary.org/obo/CL_0000868` -#### Removed -- [lymph node macrophage](http://purl.obolibrary.org/obo/CL_0000868) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +### lymphangioblast `http://purl.obolibrary.org/obo/CL_0005020` + +#### Added +- [lymphangioblast](http://purl.obolibrary.org/obo/CL_0005020) SubClassOf [perivascular cell](http://purl.obolibrary.org/obo/CL_4033054) -### lymph vasculature `http://purl.obolibrary.org/obo/UBERON_0004536` +### lymphoblast `http://purl.obolibrary.org/obo/CL_0017005` #### Removed -- [lymph vasculature](http://purl.obolibrary.org/obo/UBERON_0004536) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [lymphoblast](http://purl.obolibrary.org/obo/CL_0017005) SubClassOf [lymphocyte](http://purl.obolibrary.org/obo/CL_0000542) and ([output of](http://purl.obolibrary.org/obo/RO_0002353) some [lymphocyte activation](http://purl.obolibrary.org/obo/GO_0046649)) + +#### Added +- [lymphoblast](http://purl.obolibrary.org/obo/CL_0017005) SubClassOf [output of](http://purl.obolibrary.org/obo/RO_0002353) some [lymphocyte activation](http://purl.obolibrary.org/obo/GO_0046649) +- [lymphoblast](http://purl.obolibrary.org/obo/CL_0017005) SubClassOf [lymphocyte](http://purl.obolibrary.org/obo/CL_0000542) -### lymphatic vessel `http://purl.obolibrary.org/obo/UBERON_0001473` +### macroautophagy `http://purl.obolibrary.org/obo/GO_0016236` #### Removed -- [lymphatic vessel](http://purl.obolibrary.org/obo/UBERON_0001473) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [macroautophagy](http://purl.obolibrary.org/obo/GO_0016236) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "autophagy" +- [macroautophagy](http://purl.obolibrary.org/obo/GO_0016236) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0016236" +- [macroautophagy](http://purl.obolibrary.org/obo/GO_0016236) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "Targeted macroautophagy sometimes targets regions of cytoplasm containing non-self, such as virus particles or components (e.g. see PMID:20159618). As this is essentially the same process as macroautophagy that encloses and digests only self, the term autophagy is still used despite the enclosure of some non-self (non-auto) entities." -### lymphocyte antigen 75 `http://purl.obolibrary.org/obo/PR_000001026` +- [macroautophagy](http://purl.obolibrary.org/obo/GO_0016236) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" -#### Added -- [lymphocyte antigen 75](http://purl.obolibrary.org/obo/PR_000001026) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [lymphocyte antigen 75 (human)](http://purl.obolibrary.org/obo/PR_000034294) +- [macroautophagy](http://purl.obolibrary.org/obo/GO_0016236) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane-bounded autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane-bounded structure. Autophagosomes then fuse with a lysosome (or vacuole) releasing single-membrane-bounded autophagic bodies that are then degraded within the lysosome (or vacuole). Some types of macroautophagy, e.g. pexophagy, mitophagy, involve selective targeting of the targets to be degraded." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:11099404" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:9412464" -### lymphocyte of B lineage, CD19-positive `http://purl.obolibrary.org/obo/CL_0001200` -#### Removed -- [lymphocyte of B lineage, CD19-positive](http://purl.obolibrary.org/obo/CL_0001200) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:16973210" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:15798367" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:20159618" -### lymphoid tissue `http://purl.obolibrary.org/obo/UBERON_0001744` -#### Removed -- [lymphoid tissue](http://purl.obolibrary.org/obo/UBERON_0001744) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:12914914" +- [macroautophagy](http://purl.obolibrary.org/obo/GO_0016236) [label](http://www.w3.org/2000/01/rdf-schema#label) "macroautophagy" +- [macroautophagy](http://purl.obolibrary.org/obo/GO_0016236) [has_alternative_id](http://www.geneontology.org/formats/oboInOwl#hasAlternativeId) "GO:0034262" -### lymphoid tissue–inducer cell `http://purl.obolibrary.org/obo/CL_0011018` -#### Removed -- [lymphoid tissue–inducer cell](http://purl.obolibrary.org/obo/CL_0011018) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- Class: [macroautophagy](http://purl.obolibrary.org/obo/GO_0016236) +- [macroautophagy](http://purl.obolibrary.org/obo/GO_0016236) EquivalentTo [autophagy](http://purl.obolibrary.org/obo/GO_0006914) and ([starts with](http://purl.obolibrary.org/obo/RO_0002224) some [autophagosome assembly](http://purl.obolibrary.org/obo/GO_0000045)) +- [macroautophagy](http://purl.obolibrary.org/obo/GO_0016236) SubClassOf [autophagy](http://purl.obolibrary.org/obo/GO_0006914) -### lysosome-associated membrane glycoprotein 5 `http://purl.obolibrary.org/obo/PR_000032148` +- [macroautophagy](http://purl.obolibrary.org/obo/GO_0016236) SubClassOf [starts with](http://purl.obolibrary.org/obo/RO_0002224) some [autophagosome assembly](http://purl.obolibrary.org/obo/GO_0000045) -#### Added -- [lysosome-associated membrane glycoprotein 5](http://purl.obolibrary.org/obo/PR_000032148) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [lysosome-associated membrane glycoprotein 5 (human)](http://purl.obolibrary.org/obo/PR_Q9UJQ1) -### macroglial cell `http://purl.obolibrary.org/obo/CL_0000126` +### macromolecule biosynthetic process `http://purl.obolibrary.org/obo/GO_0009059` +#### Removed +- [macromolecule biosynthetic process](http://purl.obolibrary.org/obo/GO_0009059) [term tracker item](http://purl.obolibrary.org/obo/IAO_0000233) "http://amigo.geneontology.org/amigo/term/GO:0070589"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI) #### Added -- [macroglial cell](http://purl.obolibrary.org/obo/CL_0000126) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "macroglia" - - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [plural term](http://purl.obolibrary.org/obo/uberon#PLURAL) +- [macromolecule biosynthetic process](http://purl.obolibrary.org/obo/GO_0009059) [term tracker item](http://purl.obolibrary.org/obo/IAO_0000233) "https://github.com/geneontology/go-ontology/issues/25418"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI) - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1152/physrev.2001.81.2.871" +- [macromolecule biosynthetic process](http://purl.obolibrary.org/obo/GO_0009059) [term tracker item](http://purl.obolibrary.org/obo/IAO_0000233) "https://github.com/geneontology/go-ontology/issues/15249"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI) +- [macromolecule biosynthetic process](http://purl.obolibrary.org/obo/GO_0009059) SubClassOf [cellular biosynthetic process](http://purl.obolibrary.org/obo/GO_0044249) -### macrophage colony-stimulating factor 1 receptor `http://purl.obolibrary.org/obo/PR_000002062` + +### maintenance of Golgi location `http://purl.obolibrary.org/obo/GO_0051684` #### Added -- [macrophage colony-stimulating factor 1 receptor](http://purl.obolibrary.org/obo/PR_000002062) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [macrophage colony-stimulating factor 1 receptor (human)](http://purl.obolibrary.org/obo/PR_P07333) +- [maintenance of Golgi location](http://purl.obolibrary.org/obo/GO_0051684) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "maintenance of Golgi apparatus localization" +- [maintenance of Golgi location](http://purl.obolibrary.org/obo/GO_0051684) [label](http://www.w3.org/2000/01/rdf-schema#label) "maintenance of Golgi location" -### macrophage derived foam cell `http://purl.obolibrary.org/obo/CL_0000517` -#### Removed -- [macrophage derived foam cell](http://purl.obolibrary.org/obo/CL_0000517) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [maintenance of Golgi location](http://purl.obolibrary.org/obo/GO_0051684) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" +- [maintenance of Golgi location](http://purl.obolibrary.org/obo/GO_0051684) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process in which the Golgi is maintained in a specific location within a cell and prevented from moving elsewhere." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dph" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:tb" -### macrophage mannose receptor 1 `http://purl.obolibrary.org/obo/PR_000002972` + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:ai" -#### Added -- [macrophage mannose receptor 1](http://purl.obolibrary.org/obo/PR_000002972) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [macrophage mannose receptor 1 (human)](http://purl.obolibrary.org/obo/PR_P22897) +- [maintenance of Golgi location](http://purl.obolibrary.org/obo/GO_0051684) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0051684" +- [maintenance of Golgi location](http://purl.obolibrary.org/obo/GO_0051684) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "maintenance of Golgi body localization" -### macrophage receptor MARCO `http://purl.obolibrary.org/obo/PR_000001884` +- [maintenance of Golgi location](http://purl.obolibrary.org/obo/GO_0051684) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "maintenance of Golgi localization" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dph" -#### Added -- [macrophage receptor MARCO](http://purl.obolibrary.org/obo/PR_000001884) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [macrophage receptor MARCO (human)](http://purl.obolibrary.org/obo/PR_Q9UEW3) + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:tb" +- Class: [maintenance of Golgi location](http://purl.obolibrary.org/obo/GO_0051684) -### macrophage scavenger receptor types I and II `http://purl.obolibrary.org/obo/PR_000001885` +- [maintenance of Golgi location](http://purl.obolibrary.org/obo/GO_0051684) EquivalentTo [maintenance of location in cell](http://purl.obolibrary.org/obo/GO_0051651) and ([has primary input](http://purl.obolibrary.org/obo/RO_0004009) some [Golgi apparatus](http://purl.obolibrary.org/obo/GO_0005794)) -#### Added -- [macrophage scavenger receptor types I and II](http://purl.obolibrary.org/obo/PR_000001885) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [macrophage scavenger receptor types I and II (human)](http://purl.obolibrary.org/obo/PR_P21757) +- [maintenance of Golgi location](http://purl.obolibrary.org/obo/GO_0051684) SubClassOf [maintenance of organelle location](http://purl.obolibrary.org/obo/GO_0051657) + +- [maintenance of Golgi location](http://purl.obolibrary.org/obo/GO_0051684) SubClassOf [Golgi localization](http://purl.obolibrary.org/obo/GO_0051645) -### macrosialin `http://purl.obolibrary.org/obo/PR_000002064` +### maintenance of chromosome location `http://purl.obolibrary.org/obo/GO_0051652` #### Added -- [macrosialin](http://purl.obolibrary.org/obo/PR_000002064) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [macrosialin (human)](http://purl.obolibrary.org/obo/PR_P34810) +- [maintenance of chromosome location](http://purl.obolibrary.org/obo/GO_0051652) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" +- [maintenance of chromosome location](http://purl.obolibrary.org/obo/GO_0051652) [label](http://www.w3.org/2000/01/rdf-schema#label) "maintenance of chromosome location" -### magnocellular layer of dorsal nucleus of lateral geniculate body `http://purl.obolibrary.org/obo/UBERON_0013606` -#### Removed -- [magnocellular layer of dorsal nucleus of lateral geniculate body](http://purl.obolibrary.org/obo/UBERON_0013606) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [maintenance of chromosome location](http://purl.obolibrary.org/obo/GO_0051652) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0051652" +- [maintenance of chromosome location](http://purl.obolibrary.org/obo/GO_0051652) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process in which a chromosome is maintained in a specific location within a cell and prevented from moving elsewhere." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dph" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:tb" -### mammary gland connective tissue `http://purl.obolibrary.org/obo/UBERON_0003584` -#### Removed -- [mammary gland connective tissue](http://purl.obolibrary.org/obo/UBERON_0003584) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:ai" +- [maintenance of chromosome location](http://purl.obolibrary.org/obo/GO_0051652) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "maintenance of chromosome localization" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dph" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:tb" -### mammary placode `http://purl.obolibrary.org/obo/UBERON_0005311` -#### Removed -- [mammary placode](http://purl.obolibrary.org/obo/UBERON_0005311) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- Class: [maintenance of chromosome location](http://purl.obolibrary.org/obo/GO_0051652) +- [maintenance of chromosome location](http://purl.obolibrary.org/obo/GO_0051652) EquivalentTo [maintenance of location in cell](http://purl.obolibrary.org/obo/GO_0051651) and ([has primary input](http://purl.obolibrary.org/obo/RO_0004009) some [chromosome](http://purl.obolibrary.org/obo/GO_0005694)) +- [maintenance of chromosome location](http://purl.obolibrary.org/obo/GO_0051652) SubClassOf [maintenance of organelle location](http://purl.obolibrary.org/obo/GO_0051657) -### mammillary body neuron `http://purl.obolibrary.org/obo/CL_4023074` -#### Removed -- [mammillary body neuron](http://purl.obolibrary.org/obo/CL_4023074) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [maintenance of chromosome location](http://purl.obolibrary.org/obo/GO_0051652) SubClassOf [chromosome localization](http://purl.obolibrary.org/obo/GO_0050000) +### maintenance of location `http://purl.obolibrary.org/obo/GO_0051235` -### mandibular prominence `http://purl.obolibrary.org/obo/UBERON_0005867` -#### Removed -- [mandibular prominence](http://purl.obolibrary.org/obo/UBERON_0005867) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +#### Added +- [maintenance of location](http://purl.obolibrary.org/obo/GO_0051235) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "retention" +- [maintenance of location](http://purl.obolibrary.org/obo/GO_0051235) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0051235" +- [maintenance of location](http://purl.obolibrary.org/obo/GO_0051235) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "maintenance of localization" -### manual digit epithelium `http://purl.obolibrary.org/obo/UBERON_0005227` -#### Removed -- [manual digit epithelium](http://purl.obolibrary.org/obo/UBERON_0005227) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [maintenance of location](http://purl.obolibrary.org/obo/GO_0051235) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" + +- [maintenance of location](http://purl.obolibrary.org/obo/GO_0051235) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process in which a cell, substance or cellular entity, such as a protein complex or organelle, is maintained in a location and prevented from moving elsewhere." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dph" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:tb" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:ai" -### manual digit mesenchyme `http://purl.obolibrary.org/obo/UBERON_0005257` -#### Removed -- [manual digit mesenchyme](http://purl.obolibrary.org/obo/UBERON_0005257) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [maintenance of location](http://purl.obolibrary.org/obo/GO_0051235) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "sequestering" +- [maintenance of location](http://purl.obolibrary.org/obo/GO_0051235) [label](http://www.w3.org/2000/01/rdf-schema#label) "maintenance of location" +- [maintenance of location](http://purl.obolibrary.org/obo/GO_0051235) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "storage" -### mast cell `http://purl.obolibrary.org/obo/CL_0000097` -#### Removed -- [mast cell](http://purl.obolibrary.org/obo/CL_0000097) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- Class: [maintenance of location](http://purl.obolibrary.org/obo/GO_0051235) +- [maintenance of location](http://purl.obolibrary.org/obo/GO_0051235) SubClassOf [localization](http://purl.obolibrary.org/obo/GO_0051179) -### mast cell progenitor `http://purl.obolibrary.org/obo/CL_0000831` -#### Removed -- [mast cell progenitor](http://purl.obolibrary.org/obo/CL_0000831) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +### maintenance of location in cell `http://purl.obolibrary.org/obo/GO_0051651` +#### Added +- [maintenance of location in cell](http://purl.obolibrary.org/obo/GO_0051651) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "cellular storage" +- [maintenance of location in cell](http://purl.obolibrary.org/obo/GO_0051651) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "intracellular sequestering" -### mature T cell `http://purl.obolibrary.org/obo/CL_0002419` -#### Removed -- [mature T cell](http://purl.obolibrary.org/obo/CL_0002419) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [maintenance of location in cell](http://purl.obolibrary.org/obo/GO_0051651) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "cellular sequestering" +- [maintenance of location in cell](http://purl.obolibrary.org/obo/GO_0051651) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0051651" +- [maintenance of location in cell](http://purl.obolibrary.org/obo/GO_0051651) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" -### maxillary prominence `http://purl.obolibrary.org/obo/UBERON_0005868` -#### Removed -- [maxillary prominence](http://purl.obolibrary.org/obo/UBERON_0005868) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [maintenance of location in cell](http://purl.obolibrary.org/obo/GO_0051651) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "intracellular retention" +- [maintenance of location in cell](http://purl.obolibrary.org/obo/GO_0051651) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "maintenance of localization within cell" +- [maintenance of location in cell](http://purl.obolibrary.org/obo/GO_0051651) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "retention within cell" -### medial border of scapula `http://purl.obolibrary.org/obo/UBERON_0007174` -#### Removed -- [medial border of scapula](http://purl.obolibrary.org/obo/UBERON_0007174) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [maintenance of location in cell](http://purl.obolibrary.org/obo/GO_0051651) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "cellular retention" +- [maintenance of location in cell](http://purl.obolibrary.org/obo/GO_0051651) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "maintenance of cellular localization" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dph" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:tb" -### medial ganglionic eminence derived GABAergic cortical interneuron `http://purl.obolibrary.org/obo/CL_4023069` +- [maintenance of location in cell](http://purl.obolibrary.org/obo/GO_0051651) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process in which a substance or cellular entity, such as a protein complex or organelle, is maintained in a specific location within, or in the membrane of, a cell, and is prevented from moving elsewhere." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:ai" -#### Added -- [medial ganglionic eminence derived GABAergic cortical interneuron](http://purl.obolibrary.org/obo/CL_4023069) [symbol](http://purl.obolibrary.org/obo/IAO_0000028) "MGE cortical gaba interneuron" +- [maintenance of location in cell](http://purl.obolibrary.org/obo/GO_0051651) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "maintenance of localization in cell" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dph" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:tb" -### medial ganglionic eminence derived interneuron `http://purl.obolibrary.org/obo/CL_4023063` -#### Removed -- [medial ganglionic eminence derived interneuron](http://purl.obolibrary.org/obo/CL_4023063) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [maintenance of location in cell](http://purl.obolibrary.org/obo/GO_0051651) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "storage within cell" -#### Added -- [medial ganglionic eminence derived interneuron](http://purl.obolibrary.org/obo/CL_4023063) [symbol](http://purl.obolibrary.org/obo/IAO_0000028) "MGE interneuron" +- [maintenance of location in cell](http://purl.obolibrary.org/obo/GO_0051651) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "intracellular storage" +- [maintenance of location in cell](http://purl.obolibrary.org/obo/GO_0051651) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "maintenance of intracellular localization" -### medial nasal prominence `http://purl.obolibrary.org/obo/UBERON_0004068` -#### Removed -- [medial nasal prominence](http://purl.obolibrary.org/obo/UBERON_0004068) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [maintenance of location in cell](http://purl.obolibrary.org/obo/GO_0051651) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "sequestering within cell" +- [maintenance of location in cell](http://purl.obolibrary.org/obo/GO_0051651) [label](http://www.w3.org/2000/01/rdf-schema#label) "maintenance of location in cell" +- Class: [maintenance of location in cell](http://purl.obolibrary.org/obo/GO_0051651) -### median lingual swelling `http://purl.obolibrary.org/obo/UBERON_0006756` -#### Removed -- [median lingual swelling](http://purl.obolibrary.org/obo/UBERON_0006756) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [maintenance of location in cell](http://purl.obolibrary.org/obo/GO_0051651) EquivalentTo [maintenance of location](http://purl.obolibrary.org/obo/GO_0051235) and ([occurs in](http://purl.obolibrary.org/obo/BFO_0000066) some [cell](http://purl.obolibrary.org/obo/CL_0000000)) +- [maintenance of location in cell](http://purl.obolibrary.org/obo/GO_0051651) SubClassOf [occurs in](http://purl.obolibrary.org/obo/BFO_0000066) some [cell](http://purl.obolibrary.org/obo/CL_0000000) +- [maintenance of location in cell](http://purl.obolibrary.org/obo/GO_0051651) SubClassOf [cellular process](http://purl.obolibrary.org/obo/GO_0009987) -### medium spiny neuron `http://purl.obolibrary.org/obo/CL_1001474` -#### Removed -- [medium spiny neuron](http://purl.obolibrary.org/obo/CL_1001474) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [maintenance of location in cell](http://purl.obolibrary.org/obo/GO_0051651) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [cellular localization](http://purl.obolibrary.org/obo/GO_0051641) +- [maintenance of location in cell](http://purl.obolibrary.org/obo/GO_0051651) SubClassOf [maintenance of location](http://purl.obolibrary.org/obo/GO_0051235) -### medium-wave-sensitive opsin `http://purl.obolibrary.org/obo/PR_000001224` +### maintenance of nucleus location `http://purl.obolibrary.org/obo/GO_0051658` #### Added -- [medium-wave-sensitive opsin](http://purl.obolibrary.org/obo/PR_000001224) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [medium-wave-sensitive opsin (human)](http://purl.obolibrary.org/obo/PR_000050522) +- [maintenance of nucleus location](http://purl.obolibrary.org/obo/GO_0051658) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "maintenance of nucleus localization" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dph" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:tb" -### medulla oblongata sulcus limitans `http://purl.obolibrary.org/obo/UBERON_0009576` -#### Removed -- [medulla oblongata sulcus limitans](http://purl.obolibrary.org/obo/UBERON_0009576) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [maintenance of nucleus location](http://purl.obolibrary.org/obo/GO_0051658) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process in which the nucleus is maintained in a specific location within a cell and prevented from moving elsewhere." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dph" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:tb" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:ai" -### medulla-projecting glutamatergic neuron of the primary motor cortex `http://purl.obolibrary.org/obo/CL_4023045` +- [maintenance of nucleus location](http://purl.obolibrary.org/obo/GO_0051658) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" -#### Added -- [medulla-projecting glutamatergic neuron of the primary motor cortex](http://purl.obolibrary.org/obo/CL_4023045) [symbol](http://purl.obolibrary.org/obo/IAO_0000028) "MY ET glut MOp" +- [maintenance of nucleus location](http://purl.obolibrary.org/obo/GO_0051658) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "maintenance of cell nucleus location" +- [maintenance of nucleus location](http://purl.obolibrary.org/obo/GO_0051658) [label](http://www.w3.org/2000/01/rdf-schema#label) "maintenance of nucleus location" -### meis2 expressing cortical GABAergic cell `http://purl.obolibrary.org/obo/CL_4023065` +- [maintenance of nucleus location](http://purl.obolibrary.org/obo/GO_0051658) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0051658" -#### Added -- [meis2 expressing cortical GABAergic cell](http://purl.obolibrary.org/obo/CL_4023065) [symbol](http://purl.obolibrary.org/obo/IAO_0000028) "meis2 GABA" +- Class: [maintenance of nucleus location](http://purl.obolibrary.org/obo/GO_0051658) +- [maintenance of nucleus location](http://purl.obolibrary.org/obo/GO_0051658) EquivalentTo [maintenance of location in cell](http://purl.obolibrary.org/obo/GO_0051651) and ([has primary input](http://purl.obolibrary.org/obo/RO_0004009) some [nucleus](http://purl.obolibrary.org/obo/GO_0005634)) -### melanocyte `http://purl.obolibrary.org/obo/CL_0000148` -#### Removed -- [melanocyte](http://purl.obolibrary.org/obo/CL_0000148) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [maintenance of nucleus location](http://purl.obolibrary.org/obo/GO_0051658) SubClassOf [nucleus localization](http://purl.obolibrary.org/obo/GO_0051647) +- [maintenance of nucleus location](http://purl.obolibrary.org/obo/GO_0051658) SubClassOf [maintenance of organelle location](http://purl.obolibrary.org/obo/GO_0051657) -### melanopsin `http://purl.obolibrary.org/obo/PR_000001243` +### maintenance of organelle location `http://purl.obolibrary.org/obo/GO_0051657` #### Added -- [melanopsin](http://purl.obolibrary.org/obo/PR_000001243) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [melanopsin (human)](http://purl.obolibrary.org/obo/PR_Q9UHM6) +- [maintenance of organelle location](http://purl.obolibrary.org/obo/GO_0051657) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" +- [maintenance of organelle location](http://purl.obolibrary.org/obo/GO_0051657) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "maintenance of organelle localization" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dph" -### meningeal cluster `http://purl.obolibrary.org/obo/UBERON_0010743` -#### Removed -- [meningeal cluster](http://purl.obolibrary.org/obo/UBERON_0010743) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:tb" +- [maintenance of organelle location](http://purl.obolibrary.org/obo/GO_0051657) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0051657" +- [maintenance of organelle location](http://purl.obolibrary.org/obo/GO_0051657) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process in which an organelle is maintained in a specific location within a cell and prevented from moving elsewhere." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dph" -### mesangial cell `http://purl.obolibrary.org/obo/CL_0000650` -#### Removed -- [mesangial cell](http://purl.obolibrary.org/obo/CL_0000650) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:tb" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:ai" +- [maintenance of organelle location](http://purl.obolibrary.org/obo/GO_0051657) [label](http://www.w3.org/2000/01/rdf-schema#label) "maintenance of organelle location" -### mesangium `http://purl.obolibrary.org/obo/UBERON_0002319` -#### Removed -- [mesangium](http://purl.obolibrary.org/obo/UBERON_0002319) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- Class: [maintenance of organelle location](http://purl.obolibrary.org/obo/GO_0051657) +- [maintenance of organelle location](http://purl.obolibrary.org/obo/GO_0051657) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [organelle localization](http://purl.obolibrary.org/obo/GO_0051640) +- [maintenance of organelle location](http://purl.obolibrary.org/obo/GO_0051657) SubClassOf [maintenance of location in cell](http://purl.obolibrary.org/obo/GO_0051651) -### mesenchyme derived from head neural crest `http://purl.obolibrary.org/obo/UBERON_0007213` -#### Removed -- [mesenchyme derived from head neural crest](http://purl.obolibrary.org/obo/UBERON_0007213) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +### maintenance of protein complex location `http://purl.obolibrary.org/obo/GO_0098544` +#### Added +- [maintenance of protein complex location](http://purl.obolibrary.org/obo/GO_0098544) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "dos" -### mesenchyme derived from trunk neural crest `http://purl.obolibrary.org/obo/UBERON_0007214` -#### Removed -- [mesenchyme derived from trunk neural crest](http://purl.obolibrary.org/obo/UBERON_0007214) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [maintenance of protein complex location](http://purl.obolibrary.org/obo/GO_0098544) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" +- [maintenance of protein complex location](http://purl.obolibrary.org/obo/GO_0098544) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0098544" +- [maintenance of protein complex location](http://purl.obolibrary.org/obo/GO_0098544) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2013-11-15T18:20:16Z" -### mesenchyme of lower jaw `http://purl.obolibrary.org/obo/UBERON_0003324` -#### Removed -- [mesenchyme of lower jaw](http://purl.obolibrary.org/obo/UBERON_0003324) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [maintenance of protein complex location](http://purl.obolibrary.org/obo/GO_0098544) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process in which a protein complex is maintained in a location and prevented from moving elsewhere. These include sequestration, stabilization to prevent transport elsewhere and the active retrieval of protein complexes that move away." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dos" +- [maintenance of protein complex location](http://purl.obolibrary.org/obo/GO_0098544) [label](http://www.w3.org/2000/01/rdf-schema#label) "maintenance of protein complex location" +- Class: [maintenance of protein complex location](http://purl.obolibrary.org/obo/GO_0098544) -### mesenchyme of upper jaw `http://purl.obolibrary.org/obo/UBERON_0003323` -#### Removed -- [mesenchyme of upper jaw](http://purl.obolibrary.org/obo/UBERON_0003323) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [maintenance of protein complex location](http://purl.obolibrary.org/obo/GO_0098544) EquivalentTo [maintenance of location](http://purl.obolibrary.org/obo/GO_0051235) and ([has primary input](http://purl.obolibrary.org/obo/RO_0004009) some [protein-containing complex](http://purl.obolibrary.org/obo/GO_0032991)) +- [maintenance of protein complex location](http://purl.obolibrary.org/obo/GO_0098544) SubClassOf [maintenance of location](http://purl.obolibrary.org/obo/GO_0051235) +- [maintenance of protein complex location](http://purl.obolibrary.org/obo/GO_0098544) SubClassOf [protein-containing complex localization](http://purl.obolibrary.org/obo/GO_0031503) -### meso-epithelial cell `http://purl.obolibrary.org/obo/CL_0002078` -#### Removed -- [meso-epithelial cell](http://purl.obolibrary.org/obo/CL_0002078) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +### maintenance of protein complex location in cytoplasm `http://purl.obolibrary.org/obo/GO_0098545` +#### Added +- [maintenance of protein complex location in cytoplasm](http://purl.obolibrary.org/obo/GO_0098545) [label](http://www.w3.org/2000/01/rdf-schema#label) "maintenance of protein complex location in cytoplasm" -### mesoderm-derived structure `http://purl.obolibrary.org/obo/UBERON_0004120` -#### Removed -- [mesoderm-derived structure](http://purl.obolibrary.org/obo/UBERON_0004120) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [maintenance of protein complex location in cytoplasm](http://purl.obolibrary.org/obo/GO_0098545) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" +- [maintenance of protein complex location in cytoplasm](http://purl.obolibrary.org/obo/GO_0098545) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process in which a protein complex is maintained in a specific location within the cytoplasm and is prevented from moving elsewhere." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dos" +- [maintenance of protein complex location in cytoplasm](http://purl.obolibrary.org/obo/GO_0098545) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "dos" -### mesopodial skeleton `http://purl.obolibrary.org/obo/UBERON_0009878` -#### Removed -- [mesopodial skeleton](http://purl.obolibrary.org/obo/UBERON_0009878) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000) +- [maintenance of protein complex location in cytoplasm](http://purl.obolibrary.org/obo/GO_0098545) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2013-11-15T20:49:15Z" +- [maintenance of protein complex location in cytoplasm](http://purl.obolibrary.org/obo/GO_0098545) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0098545" +- Class: [maintenance of protein complex location in cytoplasm](http://purl.obolibrary.org/obo/GO_0098545) -### mesopodium region `http://purl.obolibrary.org/obo/UBERON_0006716` -#### Removed -- [mesopodium region](http://purl.obolibrary.org/obo/UBERON_0006716) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000) +- [maintenance of protein complex location in cytoplasm](http://purl.obolibrary.org/obo/GO_0098545) EquivalentTo [maintenance of protein complex location](http://purl.obolibrary.org/obo/GO_0098544) and ([occurs in](http://purl.obolibrary.org/obo/BFO_0000066) some [cytoplasm](http://purl.obolibrary.org/obo/GO_0005737)) and ([has primary input](http://purl.obolibrary.org/obo/RO_0004009) some [protein-containing complex](http://purl.obolibrary.org/obo/GO_0032991)) +- [maintenance of protein complex location in cytoplasm](http://purl.obolibrary.org/obo/GO_0098545) SubClassOf [maintenance of location in cell](http://purl.obolibrary.org/obo/GO_0051651) +- [maintenance of protein complex location in cytoplasm](http://purl.obolibrary.org/obo/GO_0098545) SubClassOf [occurs in](http://purl.obolibrary.org/obo/BFO_0000066) some [cytoplasm](http://purl.obolibrary.org/obo/GO_0005737) -### metadata complete `http://purl.obolibrary.org/obo/IAO_0000120` +- [maintenance of protein complex location in cytoplasm](http://purl.obolibrary.org/obo/GO_0098545) SubClassOf [maintenance of protein complex location](http://purl.obolibrary.org/obo/GO_0098544) + + +### maintenance of protein localization in organelle `http://purl.obolibrary.org/obo/GO_0072595` #### Added -- [metadata complete](http://purl.obolibrary.org/obo/IAO_0000120) [label](http://www.w3.org/2000/01/rdf-schema#label) "metadata complete"@en +- [maintenance of protein localization in organelle](http://purl.obolibrary.org/obo/GO_0072595) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "maintenance of protein localization to organelle" -- [metadata complete](http://purl.obolibrary.org/obo/IAO_0000120) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "metadata complete"@en +- [maintenance of protein localization in organelle](http://purl.obolibrary.org/obo/GO_0072595) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process in which a protein is maintained in a specific location a specific location on or in an organelle, and is prevented from moving elsewhere. Encompasses establishment of localization in the membrane or lumen of a membrane-bounded organelle." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:mah" -- [metadata complete](http://purl.obolibrary.org/obo/IAO_0000120) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Class has all its metadata, but is either not guaranteed to be in its final location in the asserted IS_A hierarchy or refers to another class that is not complete."@en +- [maintenance of protein localization in organelle](http://purl.obolibrary.org/obo/GO_0072595) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0072595" -- Individual: [metadata complete](http://purl.obolibrary.org/obo/IAO_0000120) +- [maintenance of protein localization in organelle](http://purl.obolibrary.org/obo/GO_0072595) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "maintenance of protein localisation to organelle" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:mah" +- [maintenance of protein localization in organelle](http://purl.obolibrary.org/obo/GO_0072595) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" -### metadata incomplete `http://purl.obolibrary.org/obo/IAO_0000123` +- [maintenance of protein localization in organelle](http://purl.obolibrary.org/obo/GO_0072595) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "mah" -#### Added -- [metadata incomplete](http://purl.obolibrary.org/obo/IAO_0000123) [label](http://www.w3.org/2000/01/rdf-schema#label) "metadata incomplete"@en +- [maintenance of protein localization in organelle](http://purl.obolibrary.org/obo/GO_0072595) [label](http://www.w3.org/2000/01/rdf-schema#label) "maintenance of protein localization in organelle" -- [metadata incomplete](http://purl.obolibrary.org/obo/IAO_0000123) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "metadata incomplete"@en +- [maintenance of protein localization in organelle](http://purl.obolibrary.org/obo/GO_0072595) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2011-02-14T02:09:13Z" +- Class: [maintenance of protein localization in organelle](http://purl.obolibrary.org/obo/GO_0072595) + +- [maintenance of protein localization in organelle](http://purl.obolibrary.org/obo/GO_0072595) EquivalentTo [maintenance of protein location](http://purl.obolibrary.org/obo/GO_0045185) and ([occurs in](http://purl.obolibrary.org/obo/BFO_0000066) some [organelle](http://purl.obolibrary.org/obo/GO_0043226)) + +- [maintenance of protein localization in organelle](http://purl.obolibrary.org/obo/GO_0072595) SubClassOf [occurs in](http://purl.obolibrary.org/obo/BFO_0000066) some [organelle](http://purl.obolibrary.org/obo/GO_0043226) + +- [maintenance of protein localization in organelle](http://purl.obolibrary.org/obo/GO_0072595) SubClassOf [maintenance of protein location in cell](http://purl.obolibrary.org/obo/GO_0032507) + +- [maintenance of protein localization in organelle](http://purl.obolibrary.org/obo/GO_0072595) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [protein localization to organelle](http://purl.obolibrary.org/obo/GO_0033365) + + +### maintenance of protein location `http://purl.obolibrary.org/obo/GO_0045185` + +#### Added +- [maintenance of protein location](http://purl.obolibrary.org/obo/GO_0045185) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "protein sequestering" + +- [maintenance of protein location](http://purl.obolibrary.org/obo/GO_0045185) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process in which a protein is maintained in a location and prevented from moving elsewhere. These include sequestration, stabilization to prevent transport elsewhere and the active retrieval of proteins that do move away." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:bf" + +- [maintenance of protein location](http://purl.obolibrary.org/obo/GO_0045185) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0045185" + +- [maintenance of protein location](http://purl.obolibrary.org/obo/GO_0045185) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "protein retention" + +- [maintenance of protein location](http://purl.obolibrary.org/obo/GO_0045185) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" + +- [maintenance of protein location](http://purl.obolibrary.org/obo/GO_0045185) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "maintenance of protein localization" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dph" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:tb" + +- [maintenance of protein location](http://purl.obolibrary.org/obo/GO_0045185) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "active protein retrieval" + +- [maintenance of protein location](http://purl.obolibrary.org/obo/GO_0045185) [label](http://www.w3.org/2000/01/rdf-schema#label) "maintenance of protein location" + +- Class: [maintenance of protein location](http://purl.obolibrary.org/obo/GO_0045185) + +- [maintenance of protein location](http://purl.obolibrary.org/obo/GO_0045185) SubClassOf [maintenance of location](http://purl.obolibrary.org/obo/GO_0051235) + +- [maintenance of protein location](http://purl.obolibrary.org/obo/GO_0045185) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [protein localization](http://purl.obolibrary.org/obo/GO_0008104) + + +### maintenance of protein location in cell `http://purl.obolibrary.org/obo/GO_0032507` + +#### Added +- [maintenance of protein location in cell](http://purl.obolibrary.org/obo/GO_0032507) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0032507" + +- [maintenance of protein location in cell](http://purl.obolibrary.org/obo/GO_0032507) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "maintenance of protein localization in cell" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dph" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:tb" + +- [maintenance of protein location in cell](http://purl.obolibrary.org/obo/GO_0032507) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" + +- [maintenance of protein location in cell](http://purl.obolibrary.org/obo/GO_0032507) [label](http://www.w3.org/2000/01/rdf-schema#label) "maintenance of protein location in cell" + +- [maintenance of protein location in cell](http://purl.obolibrary.org/obo/GO_0032507) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process in which a protein is maintained in a specific location within, or in the membrane of, a cell, and is prevented from moving elsewhere." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:mah" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:isa_complete" + +- Class: [maintenance of protein location in cell](http://purl.obolibrary.org/obo/GO_0032507) + +- [maintenance of protein location in cell](http://purl.obolibrary.org/obo/GO_0032507) EquivalentTo [maintenance of protein location](http://purl.obolibrary.org/obo/GO_0045185) and ([occurs in](http://purl.obolibrary.org/obo/BFO_0000066) some [cell](http://purl.obolibrary.org/obo/CL_0000000)) + +- [maintenance of protein location in cell](http://purl.obolibrary.org/obo/GO_0032507) SubClassOf [maintenance of protein location](http://purl.obolibrary.org/obo/GO_0045185) + +- [maintenance of protein location in cell](http://purl.obolibrary.org/obo/GO_0032507) SubClassOf [maintenance of location in cell](http://purl.obolibrary.org/obo/GO_0051651) + +- [maintenance of protein location in cell](http://purl.obolibrary.org/obo/GO_0032507) SubClassOf [only in taxon](http://purl.obolibrary.org/obo/RO_0002160) some [cellular organisms](http://purl.obolibrary.org/obo/NCBITaxon_131567) + +- [maintenance of protein location in cell](http://purl.obolibrary.org/obo/GO_0032507) SubClassOf [in taxon](http://purl.obolibrary.org/obo/RO_0002162) only [cellular organisms](http://purl.obolibrary.org/obo/NCBITaxon_131567) + + +### maintenance of protein location in cell cortex `http://purl.obolibrary.org/obo/GO_0032065` + +#### Added +- [maintenance of protein location in cell cortex](http://purl.obolibrary.org/obo/GO_0032065) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A process in which a protein or protein complex is maintained in a specific location in the cell cortex." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:vw" + +- [maintenance of protein location in cell cortex](http://purl.obolibrary.org/obo/GO_0032065) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "cortical protein anchoring" + +- [maintenance of protein location in cell cortex](http://purl.obolibrary.org/obo/GO_0032065) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0032065" + +- [maintenance of protein location in cell cortex](http://purl.obolibrary.org/obo/GO_0032065) [label](http://www.w3.org/2000/01/rdf-schema#label) "maintenance of protein location in cell cortex" + +- [maintenance of protein location in cell cortex](http://purl.obolibrary.org/obo/GO_0032065) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" + +- Class: [maintenance of protein location in cell cortex](http://purl.obolibrary.org/obo/GO_0032065) + +- [maintenance of protein location in cell cortex](http://purl.obolibrary.org/obo/GO_0032065) EquivalentTo [maintenance of protein location](http://purl.obolibrary.org/obo/GO_0045185) and ([occurs in](http://purl.obolibrary.org/obo/BFO_0000066) some [cell cortex](http://purl.obolibrary.org/obo/GO_0005938)) + +- [maintenance of protein location in cell cortex](http://purl.obolibrary.org/obo/GO_0032065) SubClassOf [occurs in](http://purl.obolibrary.org/obo/BFO_0000066) some [cell cortex](http://purl.obolibrary.org/obo/GO_0005938) + +- [maintenance of protein location in cell cortex](http://purl.obolibrary.org/obo/GO_0032065) SubClassOf [maintenance of protein location in cell](http://purl.obolibrary.org/obo/GO_0032507) + + +### maintenance of protein location in nucleus `http://purl.obolibrary.org/obo/GO_0051457` + +#### Added +- [maintenance of protein location in nucleus](http://purl.obolibrary.org/obo/GO_0051457) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "sequestration of protein in nucleus" + +- [maintenance of protein location in nucleus](http://purl.obolibrary.org/obo/GO_0051457) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "maintenance of protein localization in nucleus" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dph" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:tb" + +- [maintenance of protein location in nucleus](http://purl.obolibrary.org/obo/GO_0051457) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "maintenance of protein location in cell nucleus" + +- [maintenance of protein location in nucleus](http://purl.obolibrary.org/obo/GO_0051457) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "protein storage in nucleus" + +- [maintenance of protein location in nucleus](http://purl.obolibrary.org/obo/GO_0051457) [label](http://www.w3.org/2000/01/rdf-schema#label) "maintenance of protein location in nucleus" + +- [maintenance of protein location in nucleus](http://purl.obolibrary.org/obo/GO_0051457) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "maintenance of nuclear protein localization" + +- [maintenance of protein location in nucleus](http://purl.obolibrary.org/obo/GO_0051457) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "nuclear protein retention" + +- [maintenance of protein location in nucleus](http://purl.obolibrary.org/obo/GO_0051457) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "storage of protein in nucleus" + +- [maintenance of protein location in nucleus](http://purl.obolibrary.org/obo/GO_0051457) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process in which a protein is maintained in the nucleus and prevented from moving elsewhere. These include sequestration within the nucleus, protein stabilization to prevent transport elsewhere and the active retrieval of proteins that escape the nucleus." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:ai" + +- [maintenance of protein location in nucleus](http://purl.obolibrary.org/obo/GO_0051457) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "nuclear protein sequestration" + +- [maintenance of protein location in nucleus](http://purl.obolibrary.org/obo/GO_0051457) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0051457" + +- [maintenance of protein location in nucleus](http://purl.obolibrary.org/obo/GO_0051457) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "nuclear protein sequestering" + +- [maintenance of protein location in nucleus](http://purl.obolibrary.org/obo/GO_0051457) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "protein retention in nucleus" + +- [maintenance of protein location in nucleus](http://purl.obolibrary.org/obo/GO_0051457) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" + +- [maintenance of protein location in nucleus](http://purl.obolibrary.org/obo/GO_0051457) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "protein sequestration in nucleus" + +- [maintenance of protein location in nucleus](http://purl.obolibrary.org/obo/GO_0051457) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "protein-nuclear retention" + +- Class: [maintenance of protein location in nucleus](http://purl.obolibrary.org/obo/GO_0051457) + +- [maintenance of protein location in nucleus](http://purl.obolibrary.org/obo/GO_0051457) EquivalentTo [maintenance of protein location](http://purl.obolibrary.org/obo/GO_0045185) and ([occurs in](http://purl.obolibrary.org/obo/BFO_0000066) some [nucleus](http://purl.obolibrary.org/obo/GO_0005634)) + +- [maintenance of protein location in nucleus](http://purl.obolibrary.org/obo/GO_0051457) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [protein localization to nucleus](http://purl.obolibrary.org/obo/GO_0034504) + +- [maintenance of protein location in nucleus](http://purl.obolibrary.org/obo/GO_0051457) SubClassOf [maintenance of protein localization in organelle](http://purl.obolibrary.org/obo/GO_0072595) + +- [maintenance of protein location in nucleus](http://purl.obolibrary.org/obo/GO_0051457) SubClassOf [occurs in](http://purl.obolibrary.org/obo/BFO_0000066) some [nucleus](http://purl.obolibrary.org/obo/GO_0005634) + +- [maintenance of protein location in nucleus](http://purl.obolibrary.org/obo/GO_0051457) SubClassOf [in taxon](http://purl.obolibrary.org/obo/RO_0002162) only [Eukaryota](http://purl.obolibrary.org/obo/NCBITaxon_2759) + +- [maintenance of protein location in nucleus](http://purl.obolibrary.org/obo/GO_0051457) SubClassOf [only in taxon](http://purl.obolibrary.org/obo/RO_0002160) some [Eukaryota](http://purl.obolibrary.org/obo/NCBITaxon_2759) + + +### maintenance of protein location in vacuole `http://purl.obolibrary.org/obo/GO_0072667` + +#### Added +- [maintenance of protein location in vacuole](http://purl.obolibrary.org/obo/GO_0072667) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "mah" + +- [maintenance of protein location in vacuole](http://purl.obolibrary.org/obo/GO_0072667) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0072667" + +- [maintenance of protein location in vacuole](http://purl.obolibrary.org/obo/GO_0072667) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process in which a protein is maintained in a specific location in a vacuole, and is prevented from moving elsewhere." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:mah" + +- [maintenance of protein location in vacuole](http://purl.obolibrary.org/obo/GO_0072667) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2011-02-14T02:56:57Z" + +- [maintenance of protein location in vacuole](http://purl.obolibrary.org/obo/GO_0072667) [label](http://www.w3.org/2000/01/rdf-schema#label) "maintenance of protein location in vacuole" + +- [maintenance of protein location in vacuole](http://purl.obolibrary.org/obo/GO_0072667) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" + +- Class: [maintenance of protein location in vacuole](http://purl.obolibrary.org/obo/GO_0072667) + +- [maintenance of protein location in vacuole](http://purl.obolibrary.org/obo/GO_0072667) EquivalentTo [maintenance of protein location](http://purl.obolibrary.org/obo/GO_0045185) and ([occurs in](http://purl.obolibrary.org/obo/BFO_0000066) some [vacuole](http://purl.obolibrary.org/obo/GO_0005773)) + +- [maintenance of protein location in vacuole](http://purl.obolibrary.org/obo/GO_0072667) SubClassOf [maintenance of protein localization in organelle](http://purl.obolibrary.org/obo/GO_0072595) + +- [maintenance of protein location in vacuole](http://purl.obolibrary.org/obo/GO_0072667) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [protein localization to vacuole](http://purl.obolibrary.org/obo/GO_0072665) + +- [maintenance of protein location in vacuole](http://purl.obolibrary.org/obo/GO_0072667) SubClassOf [occurs in](http://purl.obolibrary.org/obo/BFO_0000066) some [vacuole](http://purl.obolibrary.org/obo/GO_0005773) + + +### maintenance of vesicle location `http://purl.obolibrary.org/obo/GO_0051655` + +#### Added +- [maintenance of vesicle location](http://purl.obolibrary.org/obo/GO_0051655) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "maintenance of vesicle localization" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dph" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:tb" + +- [maintenance of vesicle location](http://purl.obolibrary.org/obo/GO_0051655) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0051655" + +- [maintenance of vesicle location](http://purl.obolibrary.org/obo/GO_0051655) [label](http://www.w3.org/2000/01/rdf-schema#label) "maintenance of vesicle location" + +- [maintenance of vesicle location](http://purl.obolibrary.org/obo/GO_0051655) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" + +- [maintenance of vesicle location](http://purl.obolibrary.org/obo/GO_0051655) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process in which a vesicle is maintained in a specific location within a cell and prevented from moving elsewhere." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dph" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:tb" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:ai" + +- Class: [maintenance of vesicle location](http://purl.obolibrary.org/obo/GO_0051655) + +- [maintenance of vesicle location](http://purl.obolibrary.org/obo/GO_0051655) EquivalentTo [maintenance of location in cell](http://purl.obolibrary.org/obo/GO_0051651) and ([has primary input](http://purl.obolibrary.org/obo/RO_0004009) some [vesicle](http://purl.obolibrary.org/obo/GO_0031982)) + +- [maintenance of vesicle location](http://purl.obolibrary.org/obo/GO_0051655) SubClassOf [vesicle localization](http://purl.obolibrary.org/obo/GO_0051648) + +- [maintenance of vesicle location](http://purl.obolibrary.org/obo/GO_0051655) SubClassOf [maintenance of organelle location](http://purl.obolibrary.org/obo/GO_0051657) + + +### mammary gland duct regression in males `http://purl.obolibrary.org/obo/GO_0060641` +#### Removed +- [mammary gland duct regression in males](http://purl.obolibrary.org/obo/GO_0060641) [label](http://www.w3.org/2000/01/rdf-schema#label) "mammary gland duct regression in males" + +- [mammary gland duct regression in males](http://purl.obolibrary.org/obo/GO_0060641) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" + +- [mammary gland duct regression in males](http://purl.obolibrary.org/obo/GO_0060641) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2009-05-20T04:50:57Z" + +- [mammary gland duct regression in males](http://purl.obolibrary.org/obo/GO_0060641) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The process in which the epithelium of the mammary duct is destroyed in males." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dph" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:12558599" + +- [mammary gland duct regression in males](http://purl.obolibrary.org/obo/GO_0060641) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "dph" + +- [mammary gland duct regression in males](http://purl.obolibrary.org/obo/GO_0060641) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0060641" + +- Class: [mammary gland duct regression in males](http://purl.obolibrary.org/obo/GO_0060641) + +- [mammary gland duct regression in males](http://purl.obolibrary.org/obo/GO_0060641) EquivalentTo [anatomical structure regression](http://purl.obolibrary.org/obo/GO_0060033) and ([has input](http://purl.obolibrary.org/obo/RO_0002233) some [mammary duct](http://purl.obolibrary.org/obo/UBERON_0001765)) + +- [mammary gland duct regression in males](http://purl.obolibrary.org/obo/GO_0060641) SubClassOf [anatomical structure regression](http://purl.obolibrary.org/obo/GO_0060033) + +- [mammary gland duct regression in males](http://purl.obolibrary.org/obo/GO_0060641) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [mammary gland duct morphogenesis](http://purl.obolibrary.org/obo/GO_0060603) + +- [mammary gland duct regression in males](http://purl.obolibrary.org/obo/GO_0060641) SubClassOf [has input](http://purl.obolibrary.org/obo/RO_0002233) some [mammary duct](http://purl.obolibrary.org/obo/UBERON_0001765) + + + +### matrix D1 medium spiny neuron `http://purl.obolibrary.org/obo/CL_4030043` +#### Removed +- [matrix D1 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030043) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "matrix D1-MSN" + - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation) + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) [j.cub.2021.10.015](DOI:10.1016/j.cub.2021.10.015) + +- [matrix D1 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030043) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "D1M" + - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation) + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) [j.cub.2021.10.015](DOI:10.1016/j.cub.2021.10.015) + +- [matrix D1 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030043) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A DRD1-expressing medium spiny neuron that is part of a matrix compartment of dorsal striatum." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) [j.cub.2021.10.015](DOI:10.1016/j.cub.2021.10.015) + +- [matrix D1 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030043) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "D1-matrix" + - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation) + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) [j.cub.2021.10.015](DOI:10.1016/j.cub.2021.10.015) + +- [matrix D1 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030043) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "In Rhesus macaques, both matrix D1 and D2 medium spiny neuron cell types have been noted to have enriched gene expression of the following: EPHA4, GDA, STXBP6, and SEMA3E. Broadly understood, matrix MSNs receive neocortical inputs from the associative and sensorimotor cortex and give rise to the direct and indirect pathways." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) [j.cub.2021.10.015](DOI:10.1016/j.cub.2021.10.015) + +#### Added +- [matrix D1 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030043) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "matrix D1-MSN" + - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation) + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/j.cub.2021.10.015" + +- [matrix D1 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030043) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "D1-matrix" + - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation) + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/j.cub.2021.10.015" + +- [matrix D1 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030043) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A DRD1-expressing medium spiny neuron that is part of a matrix compartment of dorsal striatum." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/j.cub.2021.10.015" + +- [matrix D1 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030043) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "D1M" + - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation) + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/j.cub.2021.10.015" + +- [matrix D1 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030043) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "In Rhesus macaques, both matrix D1 and D2 medium spiny neuron cell types have been noted to have enriched gene expression of the following: EPHA4, GDA, STXBP6, and SEMA3E. Broadly understood, matrix MSNs receive neocortical inputs from the associative and sensorimotor cortex and give rise to the direct and indirect pathways." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/j.cub.2021.10.015" + + +### matrix D2 medium spiny neuron `http://purl.obolibrary.org/obo/CL_4030047` +#### Removed +- [matrix D2 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030047) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "matrix D2-MSN" + - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation) + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) [j.cub.2021.10.015](DOI:10.1016/j.cub.2021.10.015) + +- [matrix D2 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030047) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "D2M" + - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation) + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) [j.cub.2021.10.015](DOI:10.1016/j.cub.2021.10.015) + +- [matrix D2 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030047) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A DRD2-expressing medium spiny neuron that is part of a matrix compartment of dorsal striatum." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) [j.cub.2021.10.015](DOI:10.1016/j.cub.2021.10.015) + +- [matrix D2 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030047) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "D2-matrix" + - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation) + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) [j.cub.2021.10.015](DOI:10.1016/j.cub.2021.10.015) + +- [matrix D2 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030047) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "In Rhesus macaques, both matrix D1 and D2 medium spiny neuron cell types have been noted to have enriched gene expression of the following: EPHA4, GDA, STXBP6, and SEMA3E. Broadly understood, matrix MSNs receive neocortical inputs from the associative and sensorimotor cortex and give rise to the direct and indirect pathways." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) [j.cub.2021.10.015](DOI:10.1016/j.cub.2021.10.015) + +#### Added +- [matrix D2 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030047) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A DRD2-expressing medium spiny neuron that is part of a matrix compartment of dorsal striatum." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/j.cub.2021.10.015" + +- [matrix D2 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030047) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "matrix D2-MSN" + - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation) + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/j.cub.2021.10.015" + +- [matrix D2 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030047) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "In Rhesus macaques, both matrix D1 and D2 medium spiny neuron cell types have been noted to have enriched gene expression of the following: EPHA4, GDA, STXBP6, and SEMA3E. Broadly understood, matrix MSNs receive neocortical inputs from the associative and sensorimotor cortex and give rise to the direct and indirect pathways." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/j.cub.2021.10.015" + +- [matrix D2 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030047) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "D2M" + - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation) + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/j.cub.2021.10.015" + +- [matrix D2 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030047) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "D2-matrix" + - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation) + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/j.cub.2021.10.015" + + +### mature CD4 single-positive thymocyte `http://purl.obolibrary.org/obo/CL_0002436` +#### Removed +- [mature CD4 single-positive thymocyte](http://purl.obolibrary.org/obo/CL_0002436) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "T.4SP24-.Th" + +#### Added +- [mature CD4 single-positive thymocyte](http://purl.obolibrary.org/obo/CL_0002436) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "T.4SP24-.Th" + - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation) + + +### medium field retinal amacrine cell `http://purl.obolibrary.org/obo/CL_0004252` +#### Removed +- [medium field retinal amacrine cell](http://purl.obolibrary.org/obo/CL_0004252) SubClassOf [retina horizontal cell](http://purl.obolibrary.org/obo/CL_0000745) + + + +### medullary reticular cell `http://purl.obolibrary.org/obo/CL_0009106` +#### Removed +- [medullary reticular cell](http://purl.obolibrary.org/obo/CL_0009106) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "MedRC" + - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation) + +#### Added +- [medullary reticular cell](http://purl.obolibrary.org/obo/CL_0009106) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "MedRC" + - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation) + + +### mesenchymal stem cell `http://purl.obolibrary.org/obo/CL_0000134` +#### Removed +- [mesenchymal stem cell](http://purl.obolibrary.org/obo/CL_0000134) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "MSC" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:11378515" + +- [mesenchymal stem cell](http://purl.obolibrary.org/obo/CL_0000134) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "BMSC" + +- [mesenchymal stem cell](http://purl.obolibrary.org/obo/CL_0000134) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "CFU-F" + +#### Added +- [mesenchymal stem cell](http://purl.obolibrary.org/obo/CL_0000134) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "MSC" + - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation) + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:11378515" + +- [mesenchymal stem cell](http://purl.obolibrary.org/obo/CL_0000134) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "BMSC" + - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation) + +- [mesenchymal stem cell](http://purl.obolibrary.org/obo/CL_0000134) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "CFU-F" + - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation) + + +### metadata complete `http://purl.obolibrary.org/obo/IAO_0000120` +#### Removed +- [metadata complete](http://purl.obolibrary.org/obo/IAO_0000120) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "metadata complete"@en + +- [metadata complete](http://purl.obolibrary.org/obo/IAO_0000120) [label](http://www.w3.org/2000/01/rdf-schema#label) "metadata complete"@en + +- [metadata complete](http://purl.obolibrary.org/obo/IAO_0000120) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Class has all its metadata, but is either not guaranteed to be in its final location in the asserted IS_A hierarchy or refers to another class that is not complete."@en + +- Individual: [metadata complete](http://purl.obolibrary.org/obo/IAO_0000120) + + + +### metadata incomplete `http://purl.obolibrary.org/obo/IAO_0000123` +#### Removed - [metadata incomplete](http://purl.obolibrary.org/obo/IAO_0000123) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Class is being worked on; however, the metadata (including definition) are not complete or sufficiently clear to the branch editors."@en +- [metadata incomplete](http://purl.obolibrary.org/obo/IAO_0000123) [label](http://www.w3.org/2000/01/rdf-schema#label) "metadata incomplete"@en + +- [metadata incomplete](http://purl.obolibrary.org/obo/IAO_0000123) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "metadata incomplete"@en + - Individual: [metadata incomplete](http://purl.obolibrary.org/obo/IAO_0000123) -### metanephric mesenchyme `http://purl.obolibrary.org/obo/UBERON_0003220` + +### microvillus organization `http://purl.obolibrary.org/obo/GO_0032528` +#### Removed +- [microvillus organization](http://purl.obolibrary.org/obo/GO_0032528) SubClassOf [in taxon](http://purl.obolibrary.org/obo/RO_0002162) some (not ([Fungi](http://purl.obolibrary.org/obo/NCBITaxon_4751))) + +- [microvillus organization](http://purl.obolibrary.org/obo/GO_0032528) SubClassOf not ([in taxon](http://purl.obolibrary.org/obo/RO_0002162) some [Fungi](http://purl.obolibrary.org/obo/NCBITaxon_4751)) + + + +### migratory neural crest cell `http://purl.obolibrary.org/obo/CL_0000333` +#### Removed +- [migratory neural crest cell](http://purl.obolibrary.org/obo/CL_0000333) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A cell derived from the specialized ectoderm flanking each side of the embryonic neural plate, which after the closure of the neural tube, forms masses of cells that migrate out from the dorsal aspect of the neural tube to spread throughout the body." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "MESH:A16.254.600" + +#### Added +- [migratory neural crest cell](http://purl.obolibrary.org/obo/CL_0000333) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A cell derived from the specialized ectoderm flanking each side of the embryonic neural plate, which after the closure of the neural tube, forms masses of cells that migrate out from the dorsal aspect of the neural tube to spread throughout the body." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/j.stem.2015.02.017" + + +### monoblast `http://purl.obolibrary.org/obo/CL_0000040` +#### Removed +- [monoblast](http://purl.obolibrary.org/obo/CL_0000040) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "CFU-M" + +#### Added +- [monoblast](http://purl.obolibrary.org/obo/CL_0000040) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "CFU-M" + - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation) + + +### monostratified amacrine cell `http://purl.obolibrary.org/obo/CL_0004226` +#### Removed +- [monostratified amacrine cell](http://purl.obolibrary.org/obo/CL_0004226) SubClassOf [retina horizontal cell](http://purl.obolibrary.org/obo/CL_0000745) + + + +### multi-ciliated epithelial cell `http://purl.obolibrary.org/obo/CL_0005012` #### Removed -- [metanephric mesenchyme](http://purl.obolibrary.org/obo/UBERON_0003220) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [multi-ciliated epithelial cell](http://purl.obolibrary.org/obo/CL_0005012) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "MCC"@en + +#### Added +- [multi-ciliated epithelial cell](http://purl.obolibrary.org/obo/CL_0005012) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "MCC"@en + - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation) + + +### mural cell `http://purl.obolibrary.org/obo/CL_0008034` + +#### Added +- [mural cell](http://purl.obolibrary.org/obo/CL_0008034) SubClassOf [perivascular cell](http://purl.obolibrary.org/obo/CL_4033054) + + +### muscle cell `http://purl.obolibrary.org/obo/CL_0000187` + +#### Added +- [muscle cell](http://purl.obolibrary.org/obo/CL_0000187) [depicted by](http://xmlns.com/foaf/0.1/depicted_by) "https://www.swissbiopics.org/api/image/Muscle_cells.svg"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI) + + +### named class expression `http://purl.obolibrary.org/obo/IAO_0000421` +#### Removed +- [named class expression](http://purl.obolibrary.org/obo/IAO_0000421) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "named class expression"@en + +- [named class expression](http://purl.obolibrary.org/obo/IAO_0000421) [IAO_0000117](http://purl.obolibrary.org/obo/IAO_0000117) "Alan Ruttenberg"@en + +- [named class expression](http://purl.obolibrary.org/obo/IAO_0000421) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A named class expression is a logical expression that is given a name. The name can be used in place of the expression."@en + +- [named class expression](http://purl.obolibrary.org/obo/IAO_0000421) [editor note](http://purl.obolibrary.org/obo/IAO_0000116) "named class expressions are used in order to have more concise logical definition but their extensions may not be interesting classes on their own. In languages such as OWL, with no provisions for macros, these show up as actuall classes. Tools may with to not show them as such, and to replace uses of the macros with their expansions"@en + +- [named class expression](http://purl.obolibrary.org/obo/IAO_0000421) [label](http://www.w3.org/2000/01/rdf-schema#label) "named class expression"@en + +- Individual: [named class expression](http://purl.obolibrary.org/obo/IAO_0000421) + + + +### narrow field retinal amacrine cell `http://purl.obolibrary.org/obo/CL_0004251` +#### Removed +- [narrow field retinal amacrine cell](http://purl.obolibrary.org/obo/CL_0004251) SubClassOf [retina horizontal cell](http://purl.obolibrary.org/obo/CL_0000745) + + + +### negative regulation of ATP-dependent activity `http://purl.obolibrary.org/obo/GO_0032780` +#### Removed +- [negative regulation of ATP-dependent activity](http://purl.obolibrary.org/obo/GO_0032780) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "down-regulation of ATPase activity" + +- [negative regulation of ATP-dependent activity](http://purl.obolibrary.org/obo/GO_0032780) [label](http://www.w3.org/2000/01/rdf-schema#label) "negative regulation of ATP-dependent activity" + +- [negative regulation of ATP-dependent activity](http://purl.obolibrary.org/obo/GO_0032780) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" + +- [negative regulation of ATP-dependent activity](http://purl.obolibrary.org/obo/GO_0032780) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that stops or reduces the rate of an ATP-dependent activity." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:mah" + +- [negative regulation of ATP-dependent activity](http://purl.obolibrary.org/obo/GO_0032780) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "downregulation of ATPase activity" + +- [negative regulation of ATP-dependent activity](http://purl.obolibrary.org/obo/GO_0032780) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "inhibition of ATPase activity" + +- [negative regulation of ATP-dependent activity](http://purl.obolibrary.org/obo/GO_0032780) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate) + +- [negative regulation of ATP-dependent activity](http://purl.obolibrary.org/obo/GO_0032780) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "negative regulation of adenosinetriphosphatase activity" + +- [negative regulation of ATP-dependent activity](http://purl.obolibrary.org/obo/GO_0032780) [term tracker item](http://purl.obolibrary.org/obo/IAO_0000233) "https://github.com/geneontology/go-ontology/issues/22371"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI) + +- [negative regulation of ATP-dependent activity](http://purl.obolibrary.org/obo/GO_0032780) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "down regulation of ATPase activity" + +- [negative regulation of ATP-dependent activity](http://purl.obolibrary.org/obo/GO_0032780) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "negative regulation of ATPase activity" + +- [negative regulation of ATP-dependent activity](http://purl.obolibrary.org/obo/GO_0032780) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0032780" + +- Class: [negative regulation of ATP-dependent activity](http://purl.obolibrary.org/obo/GO_0032780) + +- [negative regulation of ATP-dependent activity](http://purl.obolibrary.org/obo/GO_0032780) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([negatively regulates](http://purl.obolibrary.org/obo/RO_0002212) some [ATP-dependent activity](http://purl.obolibrary.org/obo/GO_0140657)) + +- [negative regulation of ATP-dependent activity](http://purl.obolibrary.org/obo/GO_0032780) SubClassOf [negative regulation of molecular function](http://purl.obolibrary.org/obo/GO_0044092) + +- [negative regulation of ATP-dependent activity](http://purl.obolibrary.org/obo/GO_0032780) SubClassOf [regulation of ATP-dependent activity](http://purl.obolibrary.org/obo/GO_0043462) + +- [negative regulation of ATP-dependent activity](http://purl.obolibrary.org/obo/GO_0032780) SubClassOf [negatively regulates](http://purl.obolibrary.org/obo/RO_0002212) some [ATP-dependent activity](http://purl.obolibrary.org/obo/GO_0140657) + + + +### negative regulation of Atg1/ULK1 kinase complex assembly `http://purl.obolibrary.org/obo/GO_1905865` +#### Removed +- [negative regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905865) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that stops, prevents or reduces the frequency, rate or extent of Atg1/ULK1 kinase complex assembly." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:mf" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:autophagy" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:26567215" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GO_REF:0000058" + +- [negative regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905865) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "downregulation of Atg1p signalling complex assembly" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905865) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "inhibition of ATG1/ULK1 kinase complex formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905865) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "down-regulation of ULK1-ATG13-RB1CC1 complex formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905865) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "down regulation of ATG1 kinase complex formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905865) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "negative regulation of Atg1p signalling complex assembly" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905865) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "downregulation of ULK1-ATG13-FIP200 complex formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905865) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "down regulation of ATG1/ULK1 signaling complex assembly" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905865) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "negative regulation of ULK1-ATG13-FIP200 complex formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905865) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "inhibition of ATG1/ULK1 signaling complex assembly" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905865) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "down regulation of ATG1-ATG13 complex assembly" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905865) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "down regulation of ULK1-ATG13-FIP200 complex assembly" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905865) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "downregulation of ULK1 signaling complex assembly" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905865) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "negative regulation of ATG1/ULK1 signaling complex assembly" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905865) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "inhibition of ULK1-ATG13-FIP200 complex assembly" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905865) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "inhibition of Atg1p signalling complex assembly" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905865) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "down regulation of ATG1/ULK1 kinase complex formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905865) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "downregulation of ULK1-ATG13-RB1CC1 complex assembly" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905865) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "negative regulation of ATG1-ATG13 complex formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905865) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "inhibition of Atg1p signalling complex formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905865) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "down regulation of ATG1/ULK1 kinase complex assembly" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905865) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "downregulation of ATG1-ATG13 complex formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905865) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "down-regulation of ATG1/ULK1 signaling complex assembly" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905865) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "down-regulation of ATG1 kinase complex assembly" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905865) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "down regulation of ATG1-ATG13 complex formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905865) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "down-regulation of ATG1 kinase complex formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905865) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "down-regulation of ULK1-ATG13-FIP200 complex assembly" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905865) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "down-regulation of ULK1-ATG13-FIP200 complex formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905865) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "inhibition of ATG1/ULK1 signaling complex formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905865) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "inhibition of ATG1-ATG13 complex assembly" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905865) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "downregulation of ATG1/ULK1 kinase complex formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905865) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "downregulation of ULK1-ATG13-FIP200 complex assembly" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905865) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "negative regulation of ATG1 kinase complex assembly" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905865) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "downregulation of ATG1 kinase complex assembly" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905865) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "down-regulation of Atg1p signalling complex assembly" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905865) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "down regulation of Atg1p signalling complex assembly" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905865) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "negative regulation of ULK1 signaling complex assembly" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905865) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "down regulation of ULK1-ATG13-RB1CC1 complex assembly" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905865) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "inhibition of ULK1 signaling complex formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905865) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "negative regulation of ULK1-ATG13-RB1CC1 complex formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905865) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "down-regulation of Atg1p signalling complex formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905865) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "down-regulation of ATG1-ATG13 complex assembly" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905865) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "inhibition of ULK1 signaling complex assembly" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905865) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "down-regulation of ATG1-ATG13 complex formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905865) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "downregulation of ATG1/ULK1 signaling complex assembly" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905865) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "down regulation of ULK1 signaling complex assembly" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905865) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "downregulation of ULK1 signaling complex formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905865) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "downregulation of ATG1-ATG13 complex assembly" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905865) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "negative regulation of ATG1-ATG13 complex assembly" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905865) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "inhibition of ATG1-ATG13 complex formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905865) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "downregulation of ATG1/ULK1 signaling complex formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905865) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "down-regulation of ATG1/ULK1 signaling complex formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905865) [label](http://www.w3.org/2000/01/rdf-schema#label) "negative regulation of Atg1/ULK1 kinase complex assembly" + +- [negative regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905865) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "inhibition of ULK1-ATG13-RB1CC1 complex formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905865) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "negative regulation of ULK1-ATG13-RB1CC1 complex assembly" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905865) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "down-regulation of ULK1 signaling complex formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905865) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "negative regulation of ATG1 kinase complex formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905865) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "down-regulation of ULK1-ATG13-RB1CC1 complex assembly" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905865) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "inhibition of ULK1-ATG13-RB1CC1 complex assembly" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905865) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "inhibition of ATG1 kinase complex assembly" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905865) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2017-01-26T13:23:35Z" + +- [negative regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905865) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "down regulation of ULK1-ATG13-FIP200 complex formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905865) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "downregulation of ATG1/ULK1 kinase complex assembly" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905865) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "negative regulation of ULK1-ATG13-FIP200 complex assembly" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905865) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "down regulation of Atg1p signalling complex formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905865) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "negative regulation of ATG1/ULK1 kinase complex formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905865) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "pr" + +- [negative regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905865) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "downregulation of ATG1 kinase complex formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905865) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "inhibition of ATG1 kinase complex formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905865) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "down regulation of ULK1-ATG13-RB1CC1 complex formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905865) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "downregulation of Atg1p signalling complex formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905865) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "down-regulation of ATG1/ULK1 kinase complex formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905865) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "down regulation of ATG1 kinase complex assembly" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905865) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "down regulation of ATG1/ULK1 signaling complex formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905865) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "inhibition of ULK1-ATG13-FIP200 complex formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905865) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "down regulation of ULK1 signaling complex formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905865) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "negative regulation of Atg1p signalling complex formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905865) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "inhibition of ATG1/ULK1 kinase complex assembly" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905865) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:1905865" + +- [negative regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905865) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "down-regulation of ULK1 signaling complex assembly" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905865) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "downregulation of ULK1-ATG13-RB1CC1 complex formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905865) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" + +- [negative regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905865) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "negative regulation of ATG1/ULK1 signaling complex formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905865) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "negative regulation of ULK1 signaling complex formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905865) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "down-regulation of ATG1/ULK1 kinase complex assembly" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- Class: [negative regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905865) + +- [negative regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905865) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([negatively regulates](http://purl.obolibrary.org/obo/RO_0002212) some [Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1904745)) + +- [negative regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905865) SubClassOf [negative regulation of protein-containing complex assembly](http://purl.obolibrary.org/obo/GO_0031333) + +- [negative regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905865) SubClassOf [regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905864) + +- [negative regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905865) SubClassOf [negatively regulates](http://purl.obolibrary.org/obo/RO_0002212) some [Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1904745) + + + +### negative regulation of L-glutamate import across plasma membrane `http://purl.obolibrary.org/obo/GO_0002037` + +#### Added +- [negative regulation of L-glutamate import across plasma membrane](http://purl.obolibrary.org/obo/GO_0002037) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0002037" + +- [negative regulation of L-glutamate import across plasma membrane](http://purl.obolibrary.org/obo/GO_0002037) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "regulation of L-glutamate import" + +- [negative regulation of L-glutamate import across plasma membrane](http://purl.obolibrary.org/obo/GO_0002037) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "down-regulation of L-glutamate uptake" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of L-glutamate import across plasma membrane](http://purl.obolibrary.org/obo/GO_0002037) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that stops, prevents or reduces the frequency, rate or extent of L-glutamate import into a cell." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of L-glutamate import across plasma membrane](http://purl.obolibrary.org/obo/GO_0002037) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "down regulation of L-glutamate uptake" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of L-glutamate import across plasma membrane](http://purl.obolibrary.org/obo/GO_0002037) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "downregulation of L-glutamate uptake" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of L-glutamate import across plasma membrane](http://purl.obolibrary.org/obo/GO_0002037) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "downregulation of L-glutamate import" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of L-glutamate import across plasma membrane](http://purl.obolibrary.org/obo/GO_0002037) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "down-regulation of L-glutamate import" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of L-glutamate import across plasma membrane](http://purl.obolibrary.org/obo/GO_0002037) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "downregulation of L-glutamate transport" + +- [negative regulation of L-glutamate import across plasma membrane](http://purl.obolibrary.org/obo/GO_0002037) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "negative regulation of L-glutamate import" + +- [negative regulation of L-glutamate import across plasma membrane](http://purl.obolibrary.org/obo/GO_0002037) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "down-regulation of L-glutamate transport" + +- [negative regulation of L-glutamate import across plasma membrane](http://purl.obolibrary.org/obo/GO_0002037) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "negative regulation of L-glutamate uptake" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of L-glutamate import across plasma membrane](http://purl.obolibrary.org/obo/GO_0002037) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "inhibition of L-glutamate transport" + +- [negative regulation of L-glutamate import across plasma membrane](http://purl.obolibrary.org/obo/GO_0002037) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2012-06-13T07:34:30Z" + +- [negative regulation of L-glutamate import across plasma membrane](http://purl.obolibrary.org/obo/GO_0002037) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "down regulation of L-glutamate import" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of L-glutamate import across plasma membrane](http://purl.obolibrary.org/obo/GO_0002037) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" + +- [negative regulation of L-glutamate import across plasma membrane](http://purl.obolibrary.org/obo/GO_0002037) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "al" + +- [negative regulation of L-glutamate import across plasma membrane](http://purl.obolibrary.org/obo/GO_0002037) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "down regulation of L-glutamate transport" + +- [negative regulation of L-glutamate import across plasma membrane](http://purl.obolibrary.org/obo/GO_0002037) [has_alternative_id](http://www.geneontology.org/formats/oboInOwl#hasAlternativeId) "GO:1900921" + +- [negative regulation of L-glutamate import across plasma membrane](http://purl.obolibrary.org/obo/GO_0002037) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "inhibition of L-glutamate import" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of L-glutamate import across plasma membrane](http://purl.obolibrary.org/obo/GO_0002037) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "inhibition of L-glutamate uptake" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of L-glutamate import across plasma membrane](http://purl.obolibrary.org/obo/GO_0002037) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "negative regulation of L-glutamate transport" + +- [negative regulation of L-glutamate import across plasma membrane](http://purl.obolibrary.org/obo/GO_0002037) [label](http://www.w3.org/2000/01/rdf-schema#label) "negative regulation of L-glutamate import across plasma membrane" + +- Class: [negative regulation of L-glutamate import across plasma membrane](http://purl.obolibrary.org/obo/GO_0002037) + +- [negative regulation of L-glutamate import across plasma membrane](http://purl.obolibrary.org/obo/GO_0002037) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([negatively regulates](http://purl.obolibrary.org/obo/RO_0002212) some [L-glutamate import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098712)) + +- [negative regulation of L-glutamate import across plasma membrane](http://purl.obolibrary.org/obo/GO_0002037) SubClassOf [regulation of L-glutamate import across plasma membrane](http://purl.obolibrary.org/obo/GO_0002036) + +- [negative regulation of L-glutamate import across plasma membrane](http://purl.obolibrary.org/obo/GO_0002037) SubClassOf [negative regulation of transmembrane transport](http://purl.obolibrary.org/obo/GO_0034763) + +- [negative regulation of L-glutamate import across plasma membrane](http://purl.obolibrary.org/obo/GO_0002037) SubClassOf [negatively regulates](http://purl.obolibrary.org/obo/RO_0002212) some [L-glutamate import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098712) + +- [negative regulation of L-glutamate import across plasma membrane](http://purl.obolibrary.org/obo/GO_0002037) SubClassOf [negative regulation of amino acid transport](http://purl.obolibrary.org/obo/GO_0051956) + + +### negative regulation of RNA biosynthetic process `http://purl.obolibrary.org/obo/GO_1902679` +#### Removed +- [negative regulation of RNA biosynthetic process](http://purl.obolibrary.org/obo/GO_1902679) SubClassOf [negative regulation of biosynthetic process](http://purl.obolibrary.org/obo/GO_0009890) + +#### Added +- [negative regulation of RNA biosynthetic process](http://purl.obolibrary.org/obo/GO_1902679) SubClassOf [negative regulation of macromolecule biosynthetic process](http://purl.obolibrary.org/obo/GO_0010558) + + +### negative regulation of RNA export from nucleus `http://purl.obolibrary.org/obo/GO_0046832` + +#### Added +- [negative regulation of RNA export from nucleus](http://purl.obolibrary.org/obo/GO_0046832) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "inhibition of RNA export from nucleus" + +- [negative regulation of RNA export from nucleus](http://purl.obolibrary.org/obo/GO_0046832) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "negative regulation of RNA-nucleus export" + +- [negative regulation of RNA export from nucleus](http://purl.obolibrary.org/obo/GO_0046832) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0046832" + +- [negative regulation of RNA export from nucleus](http://purl.obolibrary.org/obo/GO_0046832) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "negative regulation of RNA export from cell nucleus" + +- [negative regulation of RNA export from nucleus](http://purl.obolibrary.org/obo/GO_0046832) [label](http://www.w3.org/2000/01/rdf-schema#label) "negative regulation of RNA export from nucleus" + +- [negative regulation of RNA export from nucleus](http://purl.obolibrary.org/obo/GO_0046832) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" + +- [negative regulation of RNA export from nucleus](http://purl.obolibrary.org/obo/GO_0046832) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "negative regulation of RNA transport from nucleus to cytoplasm" + +- [negative regulation of RNA export from nucleus](http://purl.obolibrary.org/obo/GO_0046832) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "negative regulation of RNA export out of nucleus" + +- [negative regulation of RNA export from nucleus](http://purl.obolibrary.org/obo/GO_0046832) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "down-regulation of RNA export from nucleus" + +- [negative regulation of RNA export from nucleus](http://purl.obolibrary.org/obo/GO_0046832) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "down regulation of RNA export from nucleus" + +- [negative regulation of RNA export from nucleus](http://purl.obolibrary.org/obo/GO_0046832) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "downregulation of RNA export from nucleus" + +- [negative regulation of RNA export from nucleus](http://purl.obolibrary.org/obo/GO_0046832) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of RNA from the nucleus into the cytoplasm." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:bf" + +- Class: [negative regulation of RNA export from nucleus](http://purl.obolibrary.org/obo/GO_0046832) + +- [negative regulation of RNA export from nucleus](http://purl.obolibrary.org/obo/GO_0046832) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([negatively regulates](http://purl.obolibrary.org/obo/RO_0002212) some [RNA export from nucleus](http://purl.obolibrary.org/obo/GO_0006405)) + +- [negative regulation of RNA export from nucleus](http://purl.obolibrary.org/obo/GO_0046832) SubClassOf [negatively regulates](http://purl.obolibrary.org/obo/RO_0002212) some [RNA export from nucleus](http://purl.obolibrary.org/obo/GO_0006405) + +- [negative regulation of RNA export from nucleus](http://purl.obolibrary.org/obo/GO_0046832) SubClassOf [negative regulation of nucleocytoplasmic transport](http://purl.obolibrary.org/obo/GO_0046823) + +- [negative regulation of RNA export from nucleus](http://purl.obolibrary.org/obo/GO_0046832) SubClassOf [regulation of RNA export from nucleus](http://purl.obolibrary.org/obo/GO_0046831) + + +### negative regulation of RNA import into nucleus `http://purl.obolibrary.org/obo/GO_0046829` + +#### Added +- [negative regulation of RNA import into nucleus](http://purl.obolibrary.org/obo/GO_0046829) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" + +- [negative regulation of RNA import into nucleus](http://purl.obolibrary.org/obo/GO_0046829) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "down-regulation of RNA import into nucleus" + +- [negative regulation of RNA import into nucleus](http://purl.obolibrary.org/obo/GO_0046829) [label](http://www.w3.org/2000/01/rdf-schema#label) "negative regulation of RNA import into nucleus" + +- [negative regulation of RNA import into nucleus](http://purl.obolibrary.org/obo/GO_0046829) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "negative regulation of RNA-nucleus import" + +- [negative regulation of RNA import into nucleus](http://purl.obolibrary.org/obo/GO_0046829) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "down regulation of RNA import into nucleus" + +- [negative regulation of RNA import into nucleus](http://purl.obolibrary.org/obo/GO_0046829) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of RNA from the cytoplasm into the nucleus." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:bf" + +- [negative regulation of RNA import into nucleus](http://purl.obolibrary.org/obo/GO_0046829) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0046829" + +- [negative regulation of RNA import into nucleus](http://purl.obolibrary.org/obo/GO_0046829) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "inhibition of RNA import into nucleus" + +- [negative regulation of RNA import into nucleus](http://purl.obolibrary.org/obo/GO_0046829) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "negative regulation of RNA transport from cytoplasm to nucleus" + +- [negative regulation of RNA import into nucleus](http://purl.obolibrary.org/obo/GO_0046829) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "downregulation of RNA import into nucleus" + +- [negative regulation of RNA import into nucleus](http://purl.obolibrary.org/obo/GO_0046829) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "negative regulation of RNA import into cell nucleus" + +- Class: [negative regulation of RNA import into nucleus](http://purl.obolibrary.org/obo/GO_0046829) + +- [negative regulation of RNA import into nucleus](http://purl.obolibrary.org/obo/GO_0046829) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([negatively regulates](http://purl.obolibrary.org/obo/RO_0002212) some [RNA import into nucleus](http://purl.obolibrary.org/obo/GO_0006404)) + +- [negative regulation of RNA import into nucleus](http://purl.obolibrary.org/obo/GO_0046829) SubClassOf [negative regulation of nucleocytoplasmic transport](http://purl.obolibrary.org/obo/GO_0046823) + +- [negative regulation of RNA import into nucleus](http://purl.obolibrary.org/obo/GO_0046829) SubClassOf [regulation of RNA import into nucleus](http://purl.obolibrary.org/obo/GO_0046828) + +- [negative regulation of RNA import into nucleus](http://purl.obolibrary.org/obo/GO_0046829) SubClassOf [negatively regulates](http://purl.obolibrary.org/obo/RO_0002212) some [RNA import into nucleus](http://purl.obolibrary.org/obo/GO_0006404) + + +### negative regulation of anterograde dense core granule transport `http://purl.obolibrary.org/obo/GO_1901952` + +#### Added +- [negative regulation of anterograde dense core granule transport](http://purl.obolibrary.org/obo/GO_1901952) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "downregulation of anterograde dense core granule transport" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of anterograde dense core granule transport](http://purl.obolibrary.org/obo/GO_1901952) [label](http://www.w3.org/2000/01/rdf-schema#label) "negative regulation of anterograde dense core granule transport" + +- [negative regulation of anterograde dense core granule transport](http://purl.obolibrary.org/obo/GO_1901952) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2013-02-19T13:36:30Z" + +- [negative regulation of anterograde dense core granule transport](http://purl.obolibrary.org/obo/GO_1901952) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "down-regulation of anterograde dense core granule transport" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of anterograde dense core granule transport](http://purl.obolibrary.org/obo/GO_1901952) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:1901952" + +- [negative regulation of anterograde dense core granule transport](http://purl.obolibrary.org/obo/GO_1901952) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that stops, prevents or reduces the frequency, rate or extent of anterograde dense core granule transport." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:23358451" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:kmv" + +- [negative regulation of anterograde dense core granule transport](http://purl.obolibrary.org/obo/GO_1901952) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "inhibition of anterograde dense core granule transport" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of anterograde dense core granule transport](http://purl.obolibrary.org/obo/GO_1901952) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "pr" + +- [negative regulation of anterograde dense core granule transport](http://purl.obolibrary.org/obo/GO_1901952) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "down regulation of anterograde dense core granule transport" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of anterograde dense core granule transport](http://purl.obolibrary.org/obo/GO_1901952) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" + +- Class: [negative regulation of anterograde dense core granule transport](http://purl.obolibrary.org/obo/GO_1901952) + +- [negative regulation of anterograde dense core granule transport](http://purl.obolibrary.org/obo/GO_1901952) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([negatively regulates](http://purl.obolibrary.org/obo/RO_0002212) some [anterograde neuronal dense core vesicle transport](http://purl.obolibrary.org/obo/GO_1990048)) + +- [negative regulation of anterograde dense core granule transport](http://purl.obolibrary.org/obo/GO_1901952) SubClassOf [negative regulation of vesicle transport along microtubule](http://purl.obolibrary.org/obo/GO_1901609) + +- [negative regulation of anterograde dense core granule transport](http://purl.obolibrary.org/obo/GO_1901952) SubClassOf [regulation of anterograde dense core granule transport](http://purl.obolibrary.org/obo/GO_1901951) + +- [negative regulation of anterograde dense core granule transport](http://purl.obolibrary.org/obo/GO_1901952) SubClassOf [negative regulation of dense core granule transport](http://purl.obolibrary.org/obo/GO_1904810) + +- [negative regulation of anterograde dense core granule transport](http://purl.obolibrary.org/obo/GO_1901952) SubClassOf [negatively regulates](http://purl.obolibrary.org/obo/RO_0002212) some [anterograde neuronal dense core vesicle transport](http://purl.obolibrary.org/obo/GO_1990048) + + +### negative regulation of autophagic cell death `http://purl.obolibrary.org/obo/GO_1904093` +#### Removed +- [negative regulation of autophagic cell death](http://purl.obolibrary.org/obo/GO_1904093) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2015-03-26T16:41:39Z" + +- [negative regulation of autophagic cell death](http://purl.obolibrary.org/obo/GO_1904093) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "down regulation of autophagic cell death" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of autophagic cell death](http://purl.obolibrary.org/obo/GO_1904093) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that stops, prevents or reduces the frequency, rate or extent of autophagic cell death." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:bhm" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:25736836" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GO_REF:0000058" + +- [negative regulation of autophagic cell death](http://purl.obolibrary.org/obo/GO_1904093) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "down regulation of programmed cell death by macroautophagy" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of autophagic cell death](http://purl.obolibrary.org/obo/GO_1904093) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "down-regulation of type II programmed cell death" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of autophagic cell death](http://purl.obolibrary.org/obo/GO_1904093) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "inhibition of autophagic cell death" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of autophagic cell death](http://purl.obolibrary.org/obo/GO_1904093) [label](http://www.w3.org/2000/01/rdf-schema#label) "negative regulation of autophagic cell death" + +- [negative regulation of autophagic cell death](http://purl.obolibrary.org/obo/GO_1904093) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" + +- [negative regulation of autophagic cell death](http://purl.obolibrary.org/obo/GO_1904093) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "down-regulation of autophagic cell death" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of autophagic cell death](http://purl.obolibrary.org/obo/GO_1904093) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "downregulation of type II programmed cell death" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of autophagic cell death](http://purl.obolibrary.org/obo/GO_1904093) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "inhibition of programmed cell death by macroautophagy" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of autophagic cell death](http://purl.obolibrary.org/obo/GO_1904093) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "bhm" + +- [negative regulation of autophagic cell death](http://purl.obolibrary.org/obo/GO_1904093) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "negative regulation of type II programmed cell death" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of autophagic cell death](http://purl.obolibrary.org/obo/GO_1904093) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "down regulation of type II programmed cell death" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of autophagic cell death](http://purl.obolibrary.org/obo/GO_1904093) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "negative regulation of programmed cell death by macroautophagy" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of autophagic cell death](http://purl.obolibrary.org/obo/GO_1904093) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "inhibition of type II programmed cell death" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of autophagic cell death](http://purl.obolibrary.org/obo/GO_1904093) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "downregulation of programmed cell death by macroautophagy" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of autophagic cell death](http://purl.obolibrary.org/obo/GO_1904093) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "down-regulation of programmed cell death by macroautophagy" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of autophagic cell death](http://purl.obolibrary.org/obo/GO_1904093) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "downregulation of autophagic cell death" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of autophagic cell death](http://purl.obolibrary.org/obo/GO_1904093) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:1904093" + +- Class: [negative regulation of autophagic cell death](http://purl.obolibrary.org/obo/GO_1904093) + +- [negative regulation of autophagic cell death](http://purl.obolibrary.org/obo/GO_1904093) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([negatively regulates](http://purl.obolibrary.org/obo/RO_0002212) some [autophagic cell death](http://purl.obolibrary.org/obo/GO_0048102)) + +- [negative regulation of autophagic cell death](http://purl.obolibrary.org/obo/GO_1904093) SubClassOf [negatively regulates](http://purl.obolibrary.org/obo/RO_0002212) some [autophagic cell death](http://purl.obolibrary.org/obo/GO_0048102) + +- [negative regulation of autophagic cell death](http://purl.obolibrary.org/obo/GO_1904093) SubClassOf [negative regulation of programmed cell death](http://purl.obolibrary.org/obo/GO_0043069) + +- [negative regulation of autophagic cell death](http://purl.obolibrary.org/obo/GO_1904093) SubClassOf [regulation of autophagic cell death](http://purl.obolibrary.org/obo/GO_1904092) + + + +### negative regulation of autophagosome assembly `http://purl.obolibrary.org/obo/GO_1902902` +#### Removed +- [negative regulation of autophagosome assembly](http://purl.obolibrary.org/obo/GO_1902902) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "downregulation of autophagic vacuole formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of autophagosome assembly](http://purl.obolibrary.org/obo/GO_1902902) [label](http://www.w3.org/2000/01/rdf-schema#label) "negative regulation of autophagosome assembly" + +- [negative regulation of autophagosome assembly](http://purl.obolibrary.org/obo/GO_1902902) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that stops, prevents or reduces the frequency, rate or extent of autophagosome assembly." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:21975012" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:autophagy" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:als" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GO_REF:0000058" + +- [negative regulation of autophagosome assembly](http://purl.obolibrary.org/obo/GO_1902902) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" + +- [negative regulation of autophagosome assembly](http://purl.obolibrary.org/obo/GO_1902902) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "down-regulation of autophagic vacuole formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of autophagosome assembly](http://purl.obolibrary.org/obo/GO_1902902) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "downregulation of autophagosome formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of autophagosome assembly](http://purl.obolibrary.org/obo/GO_1902902) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "down regulation of PAS formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of autophagosome assembly](http://purl.obolibrary.org/obo/GO_1902902) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "downregulation of PAS formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of autophagosome assembly](http://purl.obolibrary.org/obo/GO_1902902) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "inhibition of autophagic vacuole formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of autophagosome assembly](http://purl.obolibrary.org/obo/GO_1902902) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "down regulation of autophagosome biosynthesis" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of autophagosome assembly](http://purl.obolibrary.org/obo/GO_1902902) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "downregulation of autophagic vacuole assembly" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of autophagosome assembly](http://purl.obolibrary.org/obo/GO_1902902) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "downregulation of autophagosome biosynthesis" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of autophagosome assembly](http://purl.obolibrary.org/obo/GO_1902902) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "down-regulation of autophagic vacuole assembly" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of autophagosome assembly](http://purl.obolibrary.org/obo/GO_1902902) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:1902902" + +- [negative regulation of autophagosome assembly](http://purl.obolibrary.org/obo/GO_1902902) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "negative regulation of autophagosome biosynthesis" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of autophagosome assembly](http://purl.obolibrary.org/obo/GO_1902902) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "down-regulation of PAS formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of autophagosome assembly](http://purl.obolibrary.org/obo/GO_1902902) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "down-regulation of autophagosome formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of autophagosome assembly](http://purl.obolibrary.org/obo/GO_1902902) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "negative regulation of PAS formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of autophagosome assembly](http://purl.obolibrary.org/obo/GO_1902902) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "inhibition of PAS formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of autophagosome assembly](http://purl.obolibrary.org/obo/GO_1902902) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "negative regulation of autophagic vacuole formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of autophagosome assembly](http://purl.obolibrary.org/obo/GO_1902902) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "negative regulation of autophagic vacuole assembly" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:autophagy" + +- [negative regulation of autophagosome assembly](http://purl.obolibrary.org/obo/GO_1902902) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "inhibition of autophagosome formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of autophagosome assembly](http://purl.obolibrary.org/obo/GO_1902902) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "als" + +- [negative regulation of autophagosome assembly](http://purl.obolibrary.org/obo/GO_1902902) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "down regulation of autophagic vacuole assembly" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of autophagosome assembly](http://purl.obolibrary.org/obo/GO_1902902) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "down regulation of autophagic vacuole formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of autophagosome assembly](http://purl.obolibrary.org/obo/GO_1902902) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "negative regulation of autophagosome formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of autophagosome assembly](http://purl.obolibrary.org/obo/GO_1902902) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2014-04-15T10:37:40Z" + +- [negative regulation of autophagosome assembly](http://purl.obolibrary.org/obo/GO_1902902) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "down regulation of autophagosome formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of autophagosome assembly](http://purl.obolibrary.org/obo/GO_1902902) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "inhibition of autophagosome biosynthesis" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of autophagosome assembly](http://purl.obolibrary.org/obo/GO_1902902) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "inhibition of autophagic vacuole assembly" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of autophagosome assembly](http://purl.obolibrary.org/obo/GO_1902902) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "down-regulation of autophagosome biosynthesis" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- Class: [negative regulation of autophagosome assembly](http://purl.obolibrary.org/obo/GO_1902902) + +- [negative regulation of autophagosome assembly](http://purl.obolibrary.org/obo/GO_1902902) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([negatively regulates](http://purl.obolibrary.org/obo/RO_0002212) some [autophagosome assembly](http://purl.obolibrary.org/obo/GO_0000045)) + +- [negative regulation of autophagosome assembly](http://purl.obolibrary.org/obo/GO_1902902) SubClassOf [negative regulation of organelle assembly](http://purl.obolibrary.org/obo/GO_1902116) + +- [negative regulation of autophagosome assembly](http://purl.obolibrary.org/obo/GO_1902902) SubClassOf [negatively regulates](http://purl.obolibrary.org/obo/RO_0002212) some [autophagosome assembly](http://purl.obolibrary.org/obo/GO_0000045) + +- [negative regulation of autophagosome assembly](http://purl.obolibrary.org/obo/GO_1902902) SubClassOf [regulation of autophagosome assembly](http://purl.obolibrary.org/obo/GO_2000785) + +- [negative regulation of autophagosome assembly](http://purl.obolibrary.org/obo/GO_1902902) SubClassOf [negative regulation of macroautophagy](http://purl.obolibrary.org/obo/GO_0016242) + + + +### negative regulation of autophagy `http://purl.obolibrary.org/obo/GO_0010507` +#### Removed +- [negative regulation of autophagy](http://purl.obolibrary.org/obo/GO_0010507) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" + +- [negative regulation of autophagy](http://purl.obolibrary.org/obo/GO_0010507) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0010507" + +- [negative regulation of autophagy](http://purl.obolibrary.org/obo/GO_0010507) [label](http://www.w3.org/2000/01/rdf-schema#label) "negative regulation of autophagy" + +- [negative regulation of autophagy](http://purl.obolibrary.org/obo/GO_0010507) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that stops, prevents, or reduces the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dph" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:tb" + +- Class: [negative regulation of autophagy](http://purl.obolibrary.org/obo/GO_0010507) + +- [negative regulation of autophagy](http://purl.obolibrary.org/obo/GO_0010507) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([negatively regulates](http://purl.obolibrary.org/obo/RO_0002212) some [autophagy](http://purl.obolibrary.org/obo/GO_0006914)) + +- [negative regulation of autophagy](http://purl.obolibrary.org/obo/GO_0010507) SubClassOf [negatively regulates](http://purl.obolibrary.org/obo/RO_0002212) some [autophagy](http://purl.obolibrary.org/obo/GO_0006914) + +- [negative regulation of autophagy](http://purl.obolibrary.org/obo/GO_0010507) SubClassOf [negative regulation of cellular catabolic process](http://purl.obolibrary.org/obo/GO_0031330) + +- [negative regulation of autophagy](http://purl.obolibrary.org/obo/GO_0010507) SubClassOf [regulation of autophagy](http://purl.obolibrary.org/obo/GO_0010506) + + + +### negative regulation of calcium ion export across plasma membrane `http://purl.obolibrary.org/obo/GO_1905913` + +#### Added +- [negative regulation of calcium ion export across plasma membrane](http://purl.obolibrary.org/obo/GO_1905913) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2017-02-07T13:20:48Z" + +- [negative regulation of calcium ion export across plasma membrane](http://purl.obolibrary.org/obo/GO_1905913) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "inhibition of calcium ion efflux from cell" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of calcium ion export across plasma membrane](http://purl.obolibrary.org/obo/GO_1905913) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "down-regulation of calcium ion efflux from cell" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of calcium ion export across plasma membrane](http://purl.obolibrary.org/obo/GO_1905913) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "negative regulation of calcium ion export from cell" + +- [negative regulation of calcium ion export across plasma membrane](http://purl.obolibrary.org/obo/GO_1905913) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "downregulation of calcium ion export from cell" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of calcium ion export across plasma membrane](http://purl.obolibrary.org/obo/GO_1905913) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "inhibition of calcium ion export from cell" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of calcium ion export across plasma membrane](http://purl.obolibrary.org/obo/GO_1905913) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "negative regulation of calcium ion efflux from cell" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of calcium ion export across plasma membrane](http://purl.obolibrary.org/obo/GO_1905913) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "downregulation of calcium ion efflux from cell" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of calcium ion export across plasma membrane](http://purl.obolibrary.org/obo/GO_1905913) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" + +- [negative regulation of calcium ion export across plasma membrane](http://purl.obolibrary.org/obo/GO_1905913) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "rph" + +- [negative regulation of calcium ion export across plasma membrane](http://purl.obolibrary.org/obo/GO_1905913) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that stops, prevents or reduces the frequency, rate or extent of calcium ion export across the plasma membrane." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:BHF_miRNA" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:BHF" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:22362515" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GO_REF:0000058" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:rph" + +- [negative regulation of calcium ion export across plasma membrane](http://purl.obolibrary.org/obo/GO_1905913) [label](http://www.w3.org/2000/01/rdf-schema#label) "negative regulation of calcium ion export across plasma membrane" + +- [negative regulation of calcium ion export across plasma membrane](http://purl.obolibrary.org/obo/GO_1905913) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "down regulation of calcium ion efflux from cell" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of calcium ion export across plasma membrane](http://purl.obolibrary.org/obo/GO_1905913) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "down regulation of calcium ion export from cell" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of calcium ion export across plasma membrane](http://purl.obolibrary.org/obo/GO_1905913) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "down-regulation of calcium ion export from cell" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of calcium ion export across plasma membrane](http://purl.obolibrary.org/obo/GO_1905913) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:1905913" + +- Class: [negative regulation of calcium ion export across plasma membrane](http://purl.obolibrary.org/obo/GO_1905913) + +- [negative regulation of calcium ion export across plasma membrane](http://purl.obolibrary.org/obo/GO_1905913) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([negatively regulates](http://purl.obolibrary.org/obo/RO_0002212) some [calcium ion export across plasma membrane](http://purl.obolibrary.org/obo/GO_1990034)) + +- [negative regulation of calcium ion export across plasma membrane](http://purl.obolibrary.org/obo/GO_1905913) SubClassOf [regulation of calcium ion export across plasma membrane](http://purl.obolibrary.org/obo/GO_1905912) + +- [negative regulation of calcium ion export across plasma membrane](http://purl.obolibrary.org/obo/GO_1905913) SubClassOf [negatively regulates](http://purl.obolibrary.org/obo/RO_0002212) some [calcium ion export across plasma membrane](http://purl.obolibrary.org/obo/GO_1990034) + +- [negative regulation of calcium ion export across plasma membrane](http://purl.obolibrary.org/obo/GO_1905913) SubClassOf [negative regulation of calcium ion transmembrane transport](http://purl.obolibrary.org/obo/GO_1903170) + + +### negative regulation of calcium ion import across plasma membrane `http://purl.obolibrary.org/obo/GO_1905949` + +#### Added +- [negative regulation of calcium ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_1905949) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that stops, prevents or reduces the frequency, rate or extent of calcium ion import across plasma membrane." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:17640527" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:bhm" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GO_REF:0000058" + +- [negative regulation of calcium ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_1905949) [label](http://www.w3.org/2000/01/rdf-schema#label) "negative regulation of calcium ion import across plasma membrane" + +- [negative regulation of calcium ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_1905949) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" + +- [negative regulation of calcium ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_1905949) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "downregulation of calcium ion import across plasma membrane" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of calcium ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_1905949) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "down regulation of calcium ion import across plasma membrane" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of calcium ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_1905949) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "bhm" + +- [negative regulation of calcium ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_1905949) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "An example of this is PPP3CA in human (Q08209) in PMID:17640527 (inferred from direct assay)." + +- [negative regulation of calcium ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_1905949) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:1905949" + +- [negative regulation of calcium ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_1905949) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "inhibition of calcium ion import across plasma membrane" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of calcium ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_1905949) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2017-02-17T09:42:30Z" + +- [negative regulation of calcium ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_1905949) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "down-regulation of calcium ion import across plasma membrane" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- Class: [negative regulation of calcium ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_1905949) + +- [negative regulation of calcium ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_1905949) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([negatively regulates](http://purl.obolibrary.org/obo/RO_0002212) some [calcium ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098703)) + +- [negative regulation of calcium ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_1905949) SubClassOf [negative regulation of calcium ion transmembrane transport](http://purl.obolibrary.org/obo/GO_1903170) + +- [negative regulation of calcium ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_1905949) SubClassOf [regulation of calcium ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_1905664) + +- [negative regulation of calcium ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_1905949) SubClassOf [negatively regulates](http://purl.obolibrary.org/obo/RO_0002212) some [calcium ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098703) + + +### negative regulation of cell morphogenesis involved in differentiation `http://purl.obolibrary.org/obo/GO_0010771` +#### Removed +- [negative regulation of cell morphogenesis involved in differentiation](http://purl.obolibrary.org/obo/GO_0010771) [label](http://www.w3.org/2000/01/rdf-schema#label) "negative regulation of cell morphogenesis involved in differentiation" + +- [negative regulation of cell morphogenesis involved in differentiation](http://purl.obolibrary.org/obo/GO_0010771) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([negatively regulates](http://purl.obolibrary.org/obo/RO_0002212) some [cell morphogenesis involved in differentiation](http://purl.obolibrary.org/obo/GO_0000904)) + +- [negative regulation of cell morphogenesis involved in differentiation](http://purl.obolibrary.org/obo/GO_0010771) SubClassOf [negatively regulates](http://purl.obolibrary.org/obo/RO_0002212) some [cell morphogenesis involved in differentiation](http://purl.obolibrary.org/obo/GO_0000904) + +- [negative regulation of cell morphogenesis involved in differentiation](http://purl.obolibrary.org/obo/GO_0010771) SubClassOf [regulation of cell morphogenesis involved in differentiation](http://purl.obolibrary.org/obo/GO_0010769) + +#### Added +- [negative regulation of cell morphogenesis involved in differentiation](http://purl.obolibrary.org/obo/GO_0010771) [term tracker item](http://purl.obolibrary.org/obo/IAO_0000233) "https://github.com/geneontology/go-ontology/issues/24299"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI) + +- [negative regulation of cell morphogenesis involved in differentiation](http://purl.obolibrary.org/obo/GO_0010771) [label](http://www.w3.org/2000/01/rdf-schema#label) "negative regulation of cell morphogenesis" + +- [negative regulation of cell morphogenesis involved in differentiation](http://purl.obolibrary.org/obo/GO_0010771) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([negatively regulates](http://purl.obolibrary.org/obo/RO_0002212) some [cell morphogenesis](http://purl.obolibrary.org/obo/GO_0000902)) + +- [negative regulation of cell morphogenesis involved in differentiation](http://purl.obolibrary.org/obo/GO_0010771) SubClassOf [negatively regulates](http://purl.obolibrary.org/obo/RO_0002212) some [cell morphogenesis](http://purl.obolibrary.org/obo/GO_0000902) + +- [negative regulation of cell morphogenesis involved in differentiation](http://purl.obolibrary.org/obo/GO_0010771) SubClassOf [regulation of cell morphogenesis](http://purl.obolibrary.org/obo/GO_0022604) + + +### negative regulation of cell projection organization `http://purl.obolibrary.org/obo/GO_0031345` + +#### Added +- [negative regulation of cell projection organization](http://purl.obolibrary.org/obo/GO_0031345) SubClassOf [negative regulation of cell population proliferation](http://purl.obolibrary.org/obo/GO_0008285) + + +### negative regulation of cytoplasmic translation `http://purl.obolibrary.org/obo/GO_2000766` + +#### Added +- [negative regulation of cytoplasmic translation](http://purl.obolibrary.org/obo/GO_2000766) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2011-06-20T10:39:23Z" + +- [negative regulation of cytoplasmic translation](http://purl.obolibrary.org/obo/GO_2000766) [label](http://www.w3.org/2000/01/rdf-schema#label) "negative regulation of cytoplasmic translation" + +- [negative regulation of cytoplasmic translation](http://purl.obolibrary.org/obo/GO_2000766) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:2000766" + +- [negative regulation of cytoplasmic translation](http://purl.obolibrary.org/obo/GO_2000766) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that stops, prevents or reduces the frequency, rate or extent of cytoplasmic translation." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:obol" + +- [negative regulation of cytoplasmic translation](http://purl.obolibrary.org/obo/GO_2000766) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "vw" + +- [negative regulation of cytoplasmic translation](http://purl.obolibrary.org/obo/GO_2000766) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" + +- Class: [negative regulation of cytoplasmic translation](http://purl.obolibrary.org/obo/GO_2000766) + +- [negative regulation of cytoplasmic translation](http://purl.obolibrary.org/obo/GO_2000766) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([negatively regulates](http://purl.obolibrary.org/obo/RO_0002212) some [cytoplasmic translation](http://purl.obolibrary.org/obo/GO_0002181)) + +- [negative regulation of cytoplasmic translation](http://purl.obolibrary.org/obo/GO_2000766) SubClassOf [negatively regulates](http://purl.obolibrary.org/obo/RO_0002212) some [cytoplasmic translation](http://purl.obolibrary.org/obo/GO_0002181) + +- [negative regulation of cytoplasmic translation](http://purl.obolibrary.org/obo/GO_2000766) SubClassOf [negative regulation of translation](http://purl.obolibrary.org/obo/GO_0017148) + +- [negative regulation of cytoplasmic translation](http://purl.obolibrary.org/obo/GO_2000766) SubClassOf [regulation of cytoplasmic translation](http://purl.obolibrary.org/obo/GO_2000765) + + +### negative regulation of cytoplasmic translational elongation `http://purl.obolibrary.org/obo/GO_1900248` + +#### Added +- [negative regulation of cytoplasmic translational elongation](http://purl.obolibrary.org/obo/GO_1900248) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:1900248" + +- [negative regulation of cytoplasmic translational elongation](http://purl.obolibrary.org/obo/GO_1900248) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "downregulation of cytoplasmic translational elongation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of cytoplasmic translational elongation](http://purl.obolibrary.org/obo/GO_1900248) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "vw" + +- [negative regulation of cytoplasmic translational elongation](http://purl.obolibrary.org/obo/GO_1900248) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "down regulation of cytoplasmic translational elongation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of cytoplasmic translational elongation](http://purl.obolibrary.org/obo/GO_1900248) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" + +- [negative regulation of cytoplasmic translational elongation](http://purl.obolibrary.org/obo/GO_1900248) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that stops, prevents or reduces the frequency, rate or extent of cytoplasmic translational elongation." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of cytoplasmic translational elongation](http://purl.obolibrary.org/obo/GO_1900248) [label](http://www.w3.org/2000/01/rdf-schema#label) "negative regulation of cytoplasmic translational elongation" + +- [negative regulation of cytoplasmic translational elongation](http://purl.obolibrary.org/obo/GO_1900248) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "down-regulation of cytoplasmic translational elongation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of cytoplasmic translational elongation](http://purl.obolibrary.org/obo/GO_1900248) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2012-04-03T05:07:14Z" + +- [negative regulation of cytoplasmic translational elongation](http://purl.obolibrary.org/obo/GO_1900248) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "inhibition of cytoplasmic translational elongation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- Class: [negative regulation of cytoplasmic translational elongation](http://purl.obolibrary.org/obo/GO_1900248) + +- [negative regulation of cytoplasmic translational elongation](http://purl.obolibrary.org/obo/GO_1900248) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([negatively regulates](http://purl.obolibrary.org/obo/RO_0002212) some [cytoplasmic translational elongation](http://purl.obolibrary.org/obo/GO_0002182)) + +- [negative regulation of cytoplasmic translational elongation](http://purl.obolibrary.org/obo/GO_1900248) SubClassOf [negative regulation of cytoplasmic translation](http://purl.obolibrary.org/obo/GO_2000766) + +- [negative regulation of cytoplasmic translational elongation](http://purl.obolibrary.org/obo/GO_1900248) SubClassOf [regulation of cytoplasmic translational elongation](http://purl.obolibrary.org/obo/GO_1900247) + +- [negative regulation of cytoplasmic translational elongation](http://purl.obolibrary.org/obo/GO_1900248) SubClassOf [negatively regulates](http://purl.obolibrary.org/obo/RO_0002212) some [cytoplasmic translational elongation](http://purl.obolibrary.org/obo/GO_0002182) + +- [negative regulation of cytoplasmic translational elongation](http://purl.obolibrary.org/obo/GO_1900248) SubClassOf [negative regulation of translational elongation](http://purl.obolibrary.org/obo/GO_0045900) + + +### negative regulation of cytoplasmic translational initiation `http://purl.obolibrary.org/obo/GO_1904689` + +#### Added +- [negative regulation of cytoplasmic translational initiation](http://purl.obolibrary.org/obo/GO_1904689) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that stops, prevents or reduces the frequency, rate or extent of cytoplasmic translational initiation." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:12242291" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GO_REF:0000058" + +- [negative regulation of cytoplasmic translational initiation](http://purl.obolibrary.org/obo/GO_1904689) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "dos" + +- [negative regulation of cytoplasmic translational initiation](http://purl.obolibrary.org/obo/GO_1904689) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "downregulation of cytoplasmic translational initiation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of cytoplasmic translational initiation](http://purl.obolibrary.org/obo/GO_1904689) [label](http://www.w3.org/2000/01/rdf-schema#label) "negative regulation of cytoplasmic translational initiation" + +- [negative regulation of cytoplasmic translational initiation](http://purl.obolibrary.org/obo/GO_1904689) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "down regulation of cytoplasmic translational initiation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of cytoplasmic translational initiation](http://purl.obolibrary.org/obo/GO_1904689) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2015-09-25T14:39:44Z" + +- [negative regulation of cytoplasmic translational initiation](http://purl.obolibrary.org/obo/GO_1904689) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "inhibition of cytoplasmic translational initiation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of cytoplasmic translational initiation](http://purl.obolibrary.org/obo/GO_1904689) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:1904689" + +- [negative regulation of cytoplasmic translational initiation](http://purl.obolibrary.org/obo/GO_1904689) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" + +- [negative regulation of cytoplasmic translational initiation](http://purl.obolibrary.org/obo/GO_1904689) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "down-regulation of cytoplasmic translational initiation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- Class: [negative regulation of cytoplasmic translational initiation](http://purl.obolibrary.org/obo/GO_1904689) + +- [negative regulation of cytoplasmic translational initiation](http://purl.obolibrary.org/obo/GO_1904689) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([negatively regulates](http://purl.obolibrary.org/obo/RO_0002212) some [cytoplasmic translational initiation](http://purl.obolibrary.org/obo/GO_0002183)) + +- [negative regulation of cytoplasmic translational initiation](http://purl.obolibrary.org/obo/GO_1904689) SubClassOf [regulation of cytoplasmic translational initiation](http://purl.obolibrary.org/obo/GO_1904688) + +- [negative regulation of cytoplasmic translational initiation](http://purl.obolibrary.org/obo/GO_1904689) SubClassOf [negatively regulates](http://purl.obolibrary.org/obo/RO_0002212) some [cytoplasmic translational initiation](http://purl.obolibrary.org/obo/GO_0002183) + +- [negative regulation of cytoplasmic translational initiation](http://purl.obolibrary.org/obo/GO_1904689) SubClassOf [negative regulation of translational initiation](http://purl.obolibrary.org/obo/GO_0045947) + + +### negative regulation of cytoplasmic transport `http://purl.obolibrary.org/obo/GO_1903650` + +#### Added +- [negative regulation of cytoplasmic transport](http://purl.obolibrary.org/obo/GO_1903650) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "jl" + +- [negative regulation of cytoplasmic transport](http://purl.obolibrary.org/obo/GO_1903650) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "downregulation of cytoplasmic transport" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of cytoplasmic transport](http://purl.obolibrary.org/obo/GO_1903650) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "down-regulation of cytoplasmic streaming" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of cytoplasmic transport](http://purl.obolibrary.org/obo/GO_1903650) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "inhibition of cytoplasmic streaming" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of cytoplasmic transport](http://purl.obolibrary.org/obo/GO_1903650) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "down regulation of cytoplasmic streaming" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of cytoplasmic transport](http://purl.obolibrary.org/obo/GO_1903650) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:1903650" + +- [negative regulation of cytoplasmic transport](http://purl.obolibrary.org/obo/GO_1903650) [label](http://www.w3.org/2000/01/rdf-schema#label) "negative regulation of cytoplasmic transport" + +- [negative regulation of cytoplasmic transport](http://purl.obolibrary.org/obo/GO_1903650) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "inhibition of cytoplasmic transport" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of cytoplasmic transport](http://purl.obolibrary.org/obo/GO_1903650) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "down-regulation of cytoplasmic transport" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of cytoplasmic transport](http://purl.obolibrary.org/obo/GO_1903650) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "downregulation of cytoplasmic streaming" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of cytoplasmic transport](http://purl.obolibrary.org/obo/GO_1903650) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2014-11-24T13:38:26Z" + +- [negative regulation of cytoplasmic transport](http://purl.obolibrary.org/obo/GO_1903650) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "negative regulation of cytoplasmic streaming" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of cytoplasmic transport](http://purl.obolibrary.org/obo/GO_1903650) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" + +- [negative regulation of cytoplasmic transport](http://purl.obolibrary.org/obo/GO_1903650) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that stops, prevents or reduces the frequency, rate or extent of cytoplasmic transport." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:25049409" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GO_REF:0000058" + +- [negative regulation of cytoplasmic transport](http://purl.obolibrary.org/obo/GO_1903650) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "down regulation of cytoplasmic transport" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- Class: [negative regulation of cytoplasmic transport](http://purl.obolibrary.org/obo/GO_1903650) + +- [negative regulation of cytoplasmic transport](http://purl.obolibrary.org/obo/GO_1903650) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([negatively regulates](http://purl.obolibrary.org/obo/RO_0002212) some [cytosolic transport](http://purl.obolibrary.org/obo/GO_0016482)) + +- [negative regulation of cytoplasmic transport](http://purl.obolibrary.org/obo/GO_1903650) SubClassOf [negative regulation of intracellular transport](http://purl.obolibrary.org/obo/GO_0032387) + +- [negative regulation of cytoplasmic transport](http://purl.obolibrary.org/obo/GO_1903650) SubClassOf [negatively regulates](http://purl.obolibrary.org/obo/RO_0002212) some [cytosolic transport](http://purl.obolibrary.org/obo/GO_0016482) + +- [negative regulation of cytoplasmic transport](http://purl.obolibrary.org/obo/GO_1903650) SubClassOf [regulation of cytoplasmic transport](http://purl.obolibrary.org/obo/GO_1903649) + + +### negative regulation of dense core granule transport `http://purl.obolibrary.org/obo/GO_1904810` + +#### Added +- [negative regulation of dense core granule transport](http://purl.obolibrary.org/obo/GO_1904810) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "down-regulation of dense core granule transport" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of dense core granule transport](http://purl.obolibrary.org/obo/GO_1904810) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "down-regulation of dense core vesicle transport" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of dense core granule transport](http://purl.obolibrary.org/obo/GO_1904810) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2015-11-11T10:40:18Z" + +- [negative regulation of dense core granule transport](http://purl.obolibrary.org/obo/GO_1904810) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "negative regulation of dense core vesicle transport" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of dense core granule transport](http://purl.obolibrary.org/obo/GO_1904810) [label](http://www.w3.org/2000/01/rdf-schema#label) "negative regulation of dense core granule transport" + +- [negative regulation of dense core granule transport](http://purl.obolibrary.org/obo/GO_1904810) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "down regulation of dense core vesicle transport" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of dense core granule transport](http://purl.obolibrary.org/obo/GO_1904810) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "down regulation of dense core granule transport" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of dense core granule transport](http://purl.obolibrary.org/obo/GO_1904810) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "downregulation of dense core vesicle transport" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of dense core granule transport](http://purl.obolibrary.org/obo/GO_1904810) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" + +- [negative regulation of dense core granule transport](http://purl.obolibrary.org/obo/GO_1904810) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "inhibition of dense core vesicle transport" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of dense core granule transport](http://purl.obolibrary.org/obo/GO_1904810) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "downregulation of dense core granule transport" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of dense core granule transport](http://purl.obolibrary.org/obo/GO_1904810) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that stops, prevents or reduces the frequency, rate or extent of dense core granule transport." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:22699897" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GO_REF:0000058" + +- [negative regulation of dense core granule transport](http://purl.obolibrary.org/obo/GO_1904810) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:1904810" + +- [negative regulation of dense core granule transport](http://purl.obolibrary.org/obo/GO_1904810) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "cdk-5 in C.elegans (G5ECH7) in PMID:22699897 (inferred from mutant phenotype)." + +- [negative regulation of dense core granule transport](http://purl.obolibrary.org/obo/GO_1904810) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "es" + +- [negative regulation of dense core granule transport](http://purl.obolibrary.org/obo/GO_1904810) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "inhibition of dense core granule transport" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- Class: [negative regulation of dense core granule transport](http://purl.obolibrary.org/obo/GO_1904810) + +- [negative regulation of dense core granule transport](http://purl.obolibrary.org/obo/GO_1904810) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([negatively regulates](http://purl.obolibrary.org/obo/RO_0002212) some [dense core granule transport](http://purl.obolibrary.org/obo/GO_1901950)) + +- [negative regulation of dense core granule transport](http://purl.obolibrary.org/obo/GO_1904810) SubClassOf [regulation of dense core granule transport](http://purl.obolibrary.org/obo/GO_1904809) + +- [negative regulation of dense core granule transport](http://purl.obolibrary.org/obo/GO_1904810) SubClassOf [negative regulation of cytoplasmic transport](http://purl.obolibrary.org/obo/GO_1903650) + +- [negative regulation of dense core granule transport](http://purl.obolibrary.org/obo/GO_1904810) SubClassOf [negatively regulates](http://purl.obolibrary.org/obo/RO_0002212) some [dense core granule transport](http://purl.obolibrary.org/obo/GO_1901950) + + +### negative regulation of gene expression `http://purl.obolibrary.org/obo/GO_0010629` +#### Removed +- [negative regulation of gene expression](http://purl.obolibrary.org/obo/GO_0010629) SubClassOf [negative regulation of macromolecule metabolic process](http://purl.obolibrary.org/obo/GO_0010605) + +#### Added +- [negative regulation of gene expression](http://purl.obolibrary.org/obo/GO_0010629) SubClassOf [negative regulation of macromolecule biosynthetic process](http://purl.obolibrary.org/obo/GO_0010558) + + +### negative regulation of glycine import across plasma membrane `http://purl.obolibrary.org/obo/GO_1900924` + +#### Added +- [negative regulation of glycine import across plasma membrane](http://purl.obolibrary.org/obo/GO_1900924) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "down-regulation of glycine import" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of glycine import across plasma membrane](http://purl.obolibrary.org/obo/GO_1900924) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2012-06-13T07:40:32Z" + +- [negative regulation of glycine import across plasma membrane](http://purl.obolibrary.org/obo/GO_1900924) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "inhibition of glycine import" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of glycine import across plasma membrane](http://purl.obolibrary.org/obo/GO_1900924) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that stops, prevents or reduces the frequency, rate or extent of glycine import into a cell." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of glycine import across plasma membrane](http://purl.obolibrary.org/obo/GO_1900924) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:1900924" + +- [negative regulation of glycine import across plasma membrane](http://purl.obolibrary.org/obo/GO_1900924) [label](http://www.w3.org/2000/01/rdf-schema#label) "negative regulation of glycine import across plasma membrane" + +- [negative regulation of glycine import across plasma membrane](http://purl.obolibrary.org/obo/GO_1900924) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "al" + +- [negative regulation of glycine import across plasma membrane](http://purl.obolibrary.org/obo/GO_1900924) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "down regulation of glycine import" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of glycine import across plasma membrane](http://purl.obolibrary.org/obo/GO_1900924) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" + +- [negative regulation of glycine import across plasma membrane](http://purl.obolibrary.org/obo/GO_1900924) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "downregulation of glycine import" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of glycine import across plasma membrane](http://purl.obolibrary.org/obo/GO_1900924) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "negative regulation of glycine import" + +- Class: [negative regulation of glycine import across plasma membrane](http://purl.obolibrary.org/obo/GO_1900924) + +- [negative regulation of glycine import across plasma membrane](http://purl.obolibrary.org/obo/GO_1900924) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([negatively regulates](http://purl.obolibrary.org/obo/RO_0002212) some [glycine import across plasma membrane](http://purl.obolibrary.org/obo/GO_1903804)) + +- [negative regulation of glycine import across plasma membrane](http://purl.obolibrary.org/obo/GO_1900924) SubClassOf [negatively regulates](http://purl.obolibrary.org/obo/RO_0002212) some [glycine import across plasma membrane](http://purl.obolibrary.org/obo/GO_1903804) + +- [negative regulation of glycine import across plasma membrane](http://purl.obolibrary.org/obo/GO_1900924) SubClassOf [negative regulation of amino acid transport](http://purl.obolibrary.org/obo/GO_0051956) + +- [negative regulation of glycine import across plasma membrane](http://purl.obolibrary.org/obo/GO_1900924) SubClassOf [negative regulation of transmembrane transport](http://purl.obolibrary.org/obo/GO_0034763) + +- [negative regulation of glycine import across plasma membrane](http://purl.obolibrary.org/obo/GO_1900924) SubClassOf [regulation of glycine import across plasma membrane](http://purl.obolibrary.org/obo/GO_1900923) + + +### negative regulation of histamine uptake `http://purl.obolibrary.org/obo/GO_0051617` + +#### Added +- [negative regulation of histamine uptake](http://purl.obolibrary.org/obo/GO_0051617) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0051617" + +- [negative regulation of histamine uptake](http://purl.obolibrary.org/obo/GO_0051617) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" + +- [negative regulation of histamine uptake](http://purl.obolibrary.org/obo/GO_0051617) [label](http://www.w3.org/2000/01/rdf-schema#label) "negative regulation of histamine uptake" + +- [negative regulation of histamine uptake](http://purl.obolibrary.org/obo/GO_0051617) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "down regulation of histamine uptake" + +- [negative regulation of histamine uptake](http://purl.obolibrary.org/obo/GO_0051617) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of histamine into a cell." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:ai" + +- [negative regulation of histamine uptake](http://purl.obolibrary.org/obo/GO_0051617) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "down-regulation of histamine uptake" + +- [negative regulation of histamine uptake](http://purl.obolibrary.org/obo/GO_0051617) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "negative regulation of histamine import" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dph" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:tb" + +- [negative regulation of histamine uptake](http://purl.obolibrary.org/obo/GO_0051617) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "downregulation of histamine uptake" + +- Class: [negative regulation of histamine uptake](http://purl.obolibrary.org/obo/GO_0051617) + +- [negative regulation of histamine uptake](http://purl.obolibrary.org/obo/GO_0051617) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([negatively regulates](http://purl.obolibrary.org/obo/RO_0002212) some [histamine uptake](http://purl.obolibrary.org/obo/GO_0051615)) + +- [negative regulation of histamine uptake](http://purl.obolibrary.org/obo/GO_0051617) SubClassOf [regulation of histamine uptake](http://purl.obolibrary.org/obo/GO_0051616) + +- [negative regulation of histamine uptake](http://purl.obolibrary.org/obo/GO_0051617) SubClassOf [negative regulation of neurotransmitter uptake](http://purl.obolibrary.org/obo/GO_0051581) + +- [negative regulation of histamine uptake](http://purl.obolibrary.org/obo/GO_0051617) SubClassOf [negatively regulates](http://purl.obolibrary.org/obo/RO_0002212) some [histamine uptake](http://purl.obolibrary.org/obo/GO_0051615) + + +### negative regulation of iron export across plasma membrane `http://purl.obolibrary.org/obo/GO_1904039` + +#### Added +- [negative regulation of iron export across plasma membrane](http://purl.obolibrary.org/obo/GO_1904039) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "kom" + +- [negative regulation of iron export across plasma membrane](http://purl.obolibrary.org/obo/GO_1904039) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:1904039" + +- [negative regulation of iron export across plasma membrane](http://purl.obolibrary.org/obo/GO_1904039) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "down regulation of ferrous iron export" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of iron export across plasma membrane](http://purl.obolibrary.org/obo/GO_1904039) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that stops, prevents or reduces the frequency, rate or extent of export of iron ions from inside of a cell, across the plasma membrane and into the extracellular region." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:15514116" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:kom" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:BHF" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GO_REF:0000058" + +- [negative regulation of iron export across plasma membrane](http://purl.obolibrary.org/obo/GO_1904039) [label](http://www.w3.org/2000/01/rdf-schema#label) "negative regulation of iron export across plasma membrane" + +- [negative regulation of iron export across plasma membrane](http://purl.obolibrary.org/obo/GO_1904039) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "inhibition of iron(2+) export" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of iron export across plasma membrane](http://purl.obolibrary.org/obo/GO_1904039) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2015-03-16T15:36:43Z" + +- [negative regulation of iron export across plasma membrane](http://purl.obolibrary.org/obo/GO_1904039) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "downregulation of ferrous iron export" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of iron export across plasma membrane](http://purl.obolibrary.org/obo/GO_1904039) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "negative regulation of ferrous iron export" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of iron export across plasma membrane](http://purl.obolibrary.org/obo/GO_1904039) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "negative regulation of iron(2+) export" + +- [negative regulation of iron export across plasma membrane](http://purl.obolibrary.org/obo/GO_1904039) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "inhibition of ferrous iron export" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of iron export across plasma membrane](http://purl.obolibrary.org/obo/GO_1904039) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "down-regulation of ferrous iron export" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of iron export across plasma membrane](http://purl.obolibrary.org/obo/GO_1904039) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "downregulation of iron(2+) export" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of iron export across plasma membrane](http://purl.obolibrary.org/obo/GO_1904039) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "down regulation of iron(2+) export" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of iron export across plasma membrane](http://purl.obolibrary.org/obo/GO_1904039) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "down-regulation of iron(2+) export" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of iron export across plasma membrane](http://purl.obolibrary.org/obo/GO_1904039) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" + +- Class: [negative regulation of iron export across plasma membrane](http://purl.obolibrary.org/obo/GO_1904039) + +- [negative regulation of iron export across plasma membrane](http://purl.obolibrary.org/obo/GO_1904039) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([negatively regulates](http://purl.obolibrary.org/obo/RO_0002212) some [iron ion export across plasma membrane](http://purl.obolibrary.org/obo/GO_1903988)) + +- [negative regulation of iron export across plasma membrane](http://purl.obolibrary.org/obo/GO_1904039) SubClassOf [regulation of iron export across plasma membrane](http://purl.obolibrary.org/obo/GO_1904038) + +- [negative regulation of iron export across plasma membrane](http://purl.obolibrary.org/obo/GO_1904039) SubClassOf [negative regulation of iron ion transmembrane transport](http://purl.obolibrary.org/obo/GO_0034760) + +- [negative regulation of iron export across plasma membrane](http://purl.obolibrary.org/obo/GO_1904039) SubClassOf [negatively regulates](http://purl.obolibrary.org/obo/RO_0002212) some [iron ion export across plasma membrane](http://purl.obolibrary.org/obo/GO_1903988) + + +### negative regulation of iron ion import across plasma membrane `http://purl.obolibrary.org/obo/GO_1904439` + +#### Added +- [negative regulation of iron ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_1904439) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "down regulation of ferrous ion import into cell" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of iron ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_1904439) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "down regulation of ferrous iron import across plasma membrane" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of iron ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_1904439) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "down-regulation of ferrous iron import across plasma membrane" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of iron ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_1904439) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "negative regulation of ferrous ion import into cell" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of iron ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_1904439) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "negative regulation of ferrous iron import across plasma membrane" + +- [negative regulation of iron ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_1904439) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" + +- [negative regulation of iron ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_1904439) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "downregulation of ferrous iron import across plasma membrane" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of iron ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_1904439) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "down-regulation of ferrous ion import into cell" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of iron ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_1904439) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "inhibition of ferrous ion import into cell" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of iron ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_1904439) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "negative regulation of ferrous iron import into cell" + +- [negative regulation of iron ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_1904439) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "downregulation of ferrous ion import into cell" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of iron ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_1904439) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that stops, prevents or reduces the frequency, rate or extent of iron ions import across plasma membrane." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:kom" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:18353247" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:BHF" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GO_REF:0000058" + +- [negative regulation of iron ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_1904439) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:1904439" + +- [negative regulation of iron ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_1904439) [has_alternative_id](http://www.geneontology.org/formats/oboInOwl#hasAlternativeId) "GO:1903990" + +- [negative regulation of iron ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_1904439) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2015-07-06T13:49:58Z" + +- [negative regulation of iron ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_1904439) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "rl" + +- [negative regulation of iron ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_1904439) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "inhibition of ferrous iron import across plasma membrane" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of iron ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_1904439) [label](http://www.w3.org/2000/01/rdf-schema#label) "negative regulation of iron ion import across plasma membrane" + +- Class: [negative regulation of iron ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_1904439) + +- [negative regulation of iron ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_1904439) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([negatively regulates](http://purl.obolibrary.org/obo/RO_0002212) some [iron ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098711)) + +- [negative regulation of iron ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_1904439) SubClassOf [negative regulation of iron ion transmembrane transport](http://purl.obolibrary.org/obo/GO_0034760) + +- [negative regulation of iron ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_1904439) SubClassOf [negatively regulates](http://purl.obolibrary.org/obo/RO_0002212) some [iron ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098711) + +- [negative regulation of iron ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_1904439) SubClassOf [regulation of iron ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_1904438) + + +### negative regulation of ligase activity `http://purl.obolibrary.org/obo/GO_0051352` +#### Removed +- [negative regulation of ligase activity](http://purl.obolibrary.org/obo/GO_0051352) [label](http://www.w3.org/2000/01/rdf-schema#label) "negative regulation of ligase activity" + +- [negative regulation of ligase activity](http://purl.obolibrary.org/obo/GO_0051352) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "down regulation of ligase activity" + +- [negative regulation of ligase activity](http://purl.obolibrary.org/obo/GO_0051352) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "inhibition of ligase activity" + +- [negative regulation of ligase activity](http://purl.obolibrary.org/obo/GO_0051352) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" + +- [negative regulation of ligase activity](http://purl.obolibrary.org/obo/GO_0051352) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that stops or reduces the rate of ligase activity, the catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:ai" + +- [negative regulation of ligase activity](http://purl.obolibrary.org/obo/GO_0051352) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "downregulation of ligase activity" + +- [negative regulation of ligase activity](http://purl.obolibrary.org/obo/GO_0051352) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "ligase inhibitor" + +- [negative regulation of ligase activity](http://purl.obolibrary.org/obo/GO_0051352) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "down-regulation of ligase activity" + +- [negative regulation of ligase activity](http://purl.obolibrary.org/obo/GO_0051352) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0051352" + +- [negative regulation of ligase activity](http://purl.obolibrary.org/obo/GO_0051352) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate) + +- Class: [negative regulation of ligase activity](http://purl.obolibrary.org/obo/GO_0051352) + +- [negative regulation of ligase activity](http://purl.obolibrary.org/obo/GO_0051352) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([negatively regulates](http://purl.obolibrary.org/obo/RO_0002212) some [ligase activity](http://purl.obolibrary.org/obo/GO_0016874)) + +- [negative regulation of ligase activity](http://purl.obolibrary.org/obo/GO_0051352) SubClassOf [regulation of ligase activity](http://purl.obolibrary.org/obo/GO_0051340) + +- [negative regulation of ligase activity](http://purl.obolibrary.org/obo/GO_0051352) SubClassOf [negatively regulates](http://purl.obolibrary.org/obo/RO_0002212) some [ligase activity](http://purl.obolibrary.org/obo/GO_0016874) + +- [negative regulation of ligase activity](http://purl.obolibrary.org/obo/GO_0051352) SubClassOf [negative regulation of catalytic activity](http://purl.obolibrary.org/obo/GO_0043086) + + + +### negative regulation of macroautophagy `http://purl.obolibrary.org/obo/GO_0016242` +#### Removed +- [negative regulation of macroautophagy](http://purl.obolibrary.org/obo/GO_0016242) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "down-regulation of macroautophagy" + +- [negative regulation of macroautophagy](http://purl.obolibrary.org/obo/GO_0016242) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "inhibition of macroautophagy" + +- [negative regulation of macroautophagy](http://purl.obolibrary.org/obo/GO_0016242) [label](http://www.w3.org/2000/01/rdf-schema#label) "negative regulation of macroautophagy" + +- [negative regulation of macroautophagy](http://purl.obolibrary.org/obo/GO_0016242) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "downregulation of macroautophagy" + +- [negative regulation of macroautophagy](http://purl.obolibrary.org/obo/GO_0016242) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "down regulation of macroautophagy" + +- [negative regulation of macroautophagy](http://purl.obolibrary.org/obo/GO_0016242) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0016242" + +- [negative regulation of macroautophagy](http://purl.obolibrary.org/obo/GO_0016242) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that stops, prevents, or reduces the frequency, rate or extent of macroautophagy." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:go_curators" + +- [negative regulation of macroautophagy](http://purl.obolibrary.org/obo/GO_0016242) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" + +- [negative regulation of macroautophagy](http://purl.obolibrary.org/obo/GO_0016242) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "negative regulation of starvation-induced autophagy" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dph" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:ascb_2009" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:tb" + +- Class: [negative regulation of macroautophagy](http://purl.obolibrary.org/obo/GO_0016242) + +- [negative regulation of macroautophagy](http://purl.obolibrary.org/obo/GO_0016242) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([negatively regulates](http://purl.obolibrary.org/obo/RO_0002212) some [macroautophagy](http://purl.obolibrary.org/obo/GO_0016236)) + +- [negative regulation of macroautophagy](http://purl.obolibrary.org/obo/GO_0016242) SubClassOf [regulation of macroautophagy](http://purl.obolibrary.org/obo/GO_0016241) + +- [negative regulation of macroautophagy](http://purl.obolibrary.org/obo/GO_0016242) SubClassOf [negative regulation of autophagy](http://purl.obolibrary.org/obo/GO_0010507) + +- [negative regulation of macroautophagy](http://purl.obolibrary.org/obo/GO_0016242) SubClassOf [negatively regulates](http://purl.obolibrary.org/obo/RO_0002212) some [macroautophagy](http://purl.obolibrary.org/obo/GO_0016236) + + + +### negative regulation of macromolecule biosynthetic process `http://purl.obolibrary.org/obo/GO_0010558` +#### Removed +- [negative regulation of macromolecule biosynthetic process](http://purl.obolibrary.org/obo/GO_0010558) SubClassOf [negative regulation of biosynthetic process](http://purl.obolibrary.org/obo/GO_0009890) + +#### Added +- [negative regulation of macromolecule biosynthetic process](http://purl.obolibrary.org/obo/GO_0010558) SubClassOf [negative regulation of cellular biosynthetic process](http://purl.obolibrary.org/obo/GO_0031327) + + +### negative regulation of neuron apoptotic process `http://purl.obolibrary.org/obo/GO_0043524` +#### Removed +- [negative regulation of neuron apoptotic process](http://purl.obolibrary.org/obo/GO_0043524) SubClassOf [negative regulation of neuron death](http://purl.obolibrary.org/obo/GO_1901215) + + + +### negative regulation of neuron death `http://purl.obolibrary.org/obo/GO_1901215` +#### Removed +- [negative regulation of neuron death](http://purl.obolibrary.org/obo/GO_1901215) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "downregulation of neuron cell death" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of neuron death](http://purl.obolibrary.org/obo/GO_1901215) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "down regulation of neuronal cell death" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of neuron death](http://purl.obolibrary.org/obo/GO_1901215) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "inhibition of neuronal cell death" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of neuron death](http://purl.obolibrary.org/obo/GO_1901215) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2012-08-02T09:58:07Z" + +- [negative regulation of neuron death](http://purl.obolibrary.org/obo/GO_1901215) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that stops, prevents or reduces the frequency, rate or extent of neuron death." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:rph" + +- [negative regulation of neuron death](http://purl.obolibrary.org/obo/GO_1901215) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "down-regulation of neuron cell death" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of neuron death](http://purl.obolibrary.org/obo/GO_1901215) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" + +- [negative regulation of neuron death](http://purl.obolibrary.org/obo/GO_1901215) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "down-regulation of neuron death" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of neuron death](http://purl.obolibrary.org/obo/GO_1901215) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "inhibition of neuron cell death" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of neuron death](http://purl.obolibrary.org/obo/GO_1901215) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "downregulation of neuron death" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of neuron death](http://purl.obolibrary.org/obo/GO_1901215) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:1901215" + +- [negative regulation of neuron death](http://purl.obolibrary.org/obo/GO_1901215) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "down-regulation of neuronal cell death" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of neuron death](http://purl.obolibrary.org/obo/GO_1901215) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "down regulation of neuron death" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of neuron death](http://purl.obolibrary.org/obo/GO_1901215) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "negative regulation of neuron cell death" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of neuron death](http://purl.obolibrary.org/obo/GO_1901215) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "down regulation of neuron cell death" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of neuron death](http://purl.obolibrary.org/obo/GO_1901215) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "rph" + +- [negative regulation of neuron death](http://purl.obolibrary.org/obo/GO_1901215) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "inhibition of neuron death" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of neuron death](http://purl.obolibrary.org/obo/GO_1901215) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "downregulation of neuronal cell death" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of neuron death](http://purl.obolibrary.org/obo/GO_1901215) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "negative regulation of neuronal cell death" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of neuron death](http://purl.obolibrary.org/obo/GO_1901215) [label](http://www.w3.org/2000/01/rdf-schema#label) "negative regulation of neuron death" + +- Class: [negative regulation of neuron death](http://purl.obolibrary.org/obo/GO_1901215) + +- [negative regulation of neuron death](http://purl.obolibrary.org/obo/GO_1901215) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([negatively regulates](http://purl.obolibrary.org/obo/RO_0002212) some [neuron death](http://purl.obolibrary.org/obo/GO_0070997)) + +- [negative regulation of neuron death](http://purl.obolibrary.org/obo/GO_1901215) SubClassOf [negatively regulates](http://purl.obolibrary.org/obo/RO_0002212) some [neuron death](http://purl.obolibrary.org/obo/GO_0070997) + +- [negative regulation of neuron death](http://purl.obolibrary.org/obo/GO_1901215) SubClassOf [negative regulation of cellular process](http://purl.obolibrary.org/obo/GO_0048523) + +- [negative regulation of neuron death](http://purl.obolibrary.org/obo/GO_1901215) SubClassOf [regulation of neuron death](http://purl.obolibrary.org/obo/GO_1901214) + + + +### negative regulation of neurotransmitter uptake `http://purl.obolibrary.org/obo/GO_0051581` + +#### Added +- [negative regulation of neurotransmitter uptake](http://purl.obolibrary.org/obo/GO_0051581) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "down-regulation of neurotransmitter uptake" + +- [negative regulation of neurotransmitter uptake](http://purl.obolibrary.org/obo/GO_0051581) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "downregulation of neurotransmitter uptake" + +- [negative regulation of neurotransmitter uptake](http://purl.obolibrary.org/obo/GO_0051581) [label](http://www.w3.org/2000/01/rdf-schema#label) "negative regulation of neurotransmitter uptake" + +- [negative regulation of neurotransmitter uptake](http://purl.obolibrary.org/obo/GO_0051581) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "negative regulation of neurotransmitter import" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dph" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:tb" + +- [negative regulation of neurotransmitter uptake](http://purl.obolibrary.org/obo/GO_0051581) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "down regulation of neurotransmitter uptake" + +- [negative regulation of neurotransmitter uptake](http://purl.obolibrary.org/obo/GO_0051581) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0051581" + +- [negative regulation of neurotransmitter uptake](http://purl.obolibrary.org/obo/GO_0051581) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a neurotransmitter into a neuron or glial cell." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:ai" + +- [negative regulation of neurotransmitter uptake](http://purl.obolibrary.org/obo/GO_0051581) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" + +- Class: [negative regulation of neurotransmitter uptake](http://purl.obolibrary.org/obo/GO_0051581) + +- [negative regulation of neurotransmitter uptake](http://purl.obolibrary.org/obo/GO_0051581) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([negatively regulates](http://purl.obolibrary.org/obo/RO_0002212) some [neurotransmitter uptake](http://purl.obolibrary.org/obo/GO_0001504)) + +- [negative regulation of neurotransmitter uptake](http://purl.obolibrary.org/obo/GO_0051581) SubClassOf [regulation of neurotransmitter uptake](http://purl.obolibrary.org/obo/GO_0051580) + +- [negative regulation of neurotransmitter uptake](http://purl.obolibrary.org/obo/GO_0051581) SubClassOf [negative regulation of neurotransmitter transport](http://purl.obolibrary.org/obo/GO_0051589) + +- [negative regulation of neurotransmitter uptake](http://purl.obolibrary.org/obo/GO_0051581) SubClassOf [negatively regulates](http://purl.obolibrary.org/obo/RO_0002212) some [neurotransmitter uptake](http://purl.obolibrary.org/obo/GO_0001504) + + +### negative regulation of nucleocytoplasmic transport `http://purl.obolibrary.org/obo/GO_0046823` + +#### Added +- [negative regulation of nucleocytoplasmic transport](http://purl.obolibrary.org/obo/GO_0046823) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "down-regulation of nucleocytoplasmic transport" + +- [negative regulation of nucleocytoplasmic transport](http://purl.obolibrary.org/obo/GO_0046823) [label](http://www.w3.org/2000/01/rdf-schema#label) "negative regulation of nucleocytoplasmic transport" + +- [negative regulation of nucleocytoplasmic transport](http://purl.obolibrary.org/obo/GO_0046823) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances between the cytoplasm and the nucleus." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:bf" + +- [negative regulation of nucleocytoplasmic transport](http://purl.obolibrary.org/obo/GO_0046823) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "downregulation of nucleocytoplasmic transport" + +- [negative regulation of nucleocytoplasmic transport](http://purl.obolibrary.org/obo/GO_0046823) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" + +- [negative regulation of nucleocytoplasmic transport](http://purl.obolibrary.org/obo/GO_0046823) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "inhibition of nucleocytoplasmic transport" + +- [negative regulation of nucleocytoplasmic transport](http://purl.obolibrary.org/obo/GO_0046823) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "down regulation of nucleocytoplasmic transport" + +- [negative regulation of nucleocytoplasmic transport](http://purl.obolibrary.org/obo/GO_0046823) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0046823" + +- Class: [negative regulation of nucleocytoplasmic transport](http://purl.obolibrary.org/obo/GO_0046823) + +- [negative regulation of nucleocytoplasmic transport](http://purl.obolibrary.org/obo/GO_0046823) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([negatively regulates](http://purl.obolibrary.org/obo/RO_0002212) some [nucleocytoplasmic transport](http://purl.obolibrary.org/obo/GO_0006913)) + +- [negative regulation of nucleocytoplasmic transport](http://purl.obolibrary.org/obo/GO_0046823) SubClassOf [regulation of nucleocytoplasmic transport](http://purl.obolibrary.org/obo/GO_0046822) + +- [negative regulation of nucleocytoplasmic transport](http://purl.obolibrary.org/obo/GO_0046823) SubClassOf [negative regulation of intracellular transport](http://purl.obolibrary.org/obo/GO_0032387) + +- [negative regulation of nucleocytoplasmic transport](http://purl.obolibrary.org/obo/GO_0046823) SubClassOf [negatively regulates](http://purl.obolibrary.org/obo/RO_0002212) some [nucleocytoplasmic transport](http://purl.obolibrary.org/obo/GO_0006913) + + +### negative regulation of protein export from nucleus `http://purl.obolibrary.org/obo/GO_0046826` + +#### Added +- [negative regulation of protein export from nucleus](http://purl.obolibrary.org/obo/GO_0046826) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" + +- [negative regulation of protein export from nucleus](http://purl.obolibrary.org/obo/GO_0046826) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "negative regulation of protein export out of nucleus" + +- [negative regulation of protein export from nucleus](http://purl.obolibrary.org/obo/GO_0046826) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "negative regulation of protein export from cell nucleus" + +- [negative regulation of protein export from nucleus](http://purl.obolibrary.org/obo/GO_0046826) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "negative regulation of protein-nucleus export" + +- [negative regulation of protein export from nucleus](http://purl.obolibrary.org/obo/GO_0046826) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "downregulation of protein export from nucleus" + +- [negative regulation of protein export from nucleus](http://purl.obolibrary.org/obo/GO_0046826) [label](http://www.w3.org/2000/01/rdf-schema#label) "negative regulation of protein export from nucleus" + +- [negative regulation of protein export from nucleus](http://purl.obolibrary.org/obo/GO_0046826) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0046826" + +- [negative regulation of protein export from nucleus](http://purl.obolibrary.org/obo/GO_0046826) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "negative regulation of protein transport from nucleus to cytoplasm" + +- [negative regulation of protein export from nucleus](http://purl.obolibrary.org/obo/GO_0046826) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of proteins from the nucleus into the cytoplasm." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:bf" + +- [negative regulation of protein export from nucleus](http://purl.obolibrary.org/obo/GO_0046826) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "inhibition of protein export from nucleus" + +- [negative regulation of protein export from nucleus](http://purl.obolibrary.org/obo/GO_0046826) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "down-regulation of protein export from nucleus" + +- [negative regulation of protein export from nucleus](http://purl.obolibrary.org/obo/GO_0046826) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "down regulation of protein export from nucleus" + +- Class: [negative regulation of protein export from nucleus](http://purl.obolibrary.org/obo/GO_0046826) + +- [negative regulation of protein export from nucleus](http://purl.obolibrary.org/obo/GO_0046826) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([negatively regulates](http://purl.obolibrary.org/obo/RO_0002212) some [protein export from nucleus](http://purl.obolibrary.org/obo/GO_0006611)) + +- [negative regulation of protein export from nucleus](http://purl.obolibrary.org/obo/GO_0046826) SubClassOf [maintenance of protein location in nucleus](http://purl.obolibrary.org/obo/GO_0051457) + +- [negative regulation of protein export from nucleus](http://purl.obolibrary.org/obo/GO_0046826) SubClassOf [regulation of protein export from nucleus](http://purl.obolibrary.org/obo/GO_0046825) + +- [negative regulation of protein export from nucleus](http://purl.obolibrary.org/obo/GO_0046826) SubClassOf [negative regulation of nucleocytoplasmic transport](http://purl.obolibrary.org/obo/GO_0046823) + +- [negative regulation of protein export from nucleus](http://purl.obolibrary.org/obo/GO_0046826) SubClassOf [negative regulation of intracellular protein transport](http://purl.obolibrary.org/obo/GO_0090317) + +- [negative regulation of protein export from nucleus](http://purl.obolibrary.org/obo/GO_0046826) SubClassOf [negatively regulates](http://purl.obolibrary.org/obo/RO_0002212) some [protein export from nucleus](http://purl.obolibrary.org/obo/GO_0006611) + + +### negative regulation of protein import into nucleus `http://purl.obolibrary.org/obo/GO_0042308` + +#### Added +- [negative regulation of protein import into nucleus](http://purl.obolibrary.org/obo/GO_0042308) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" + +- [negative regulation of protein import into nucleus](http://purl.obolibrary.org/obo/GO_0042308) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0042308" + +- [negative regulation of protein import into nucleus](http://purl.obolibrary.org/obo/GO_0042308) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "down regulation of protein import into nucleus" + +- [negative regulation of protein import into nucleus](http://purl.obolibrary.org/obo/GO_0042308) [label](http://www.w3.org/2000/01/rdf-schema#label) "negative regulation of protein import into nucleus" + +- [negative regulation of protein import into nucleus](http://purl.obolibrary.org/obo/GO_0042308) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of proteins from the cytoplasm into the nucleus." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:jl" + +- [negative regulation of protein import into nucleus](http://purl.obolibrary.org/obo/GO_0042308) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "negative regulation of protein import into cell nucleus" + +- [negative regulation of protein import into nucleus](http://purl.obolibrary.org/obo/GO_0042308) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "negative regulation of protein transport from cytoplasm to nucleus" + +- [negative regulation of protein import into nucleus](http://purl.obolibrary.org/obo/GO_0042308) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "down-regulation of protein import into nucleus" + +- [negative regulation of protein import into nucleus](http://purl.obolibrary.org/obo/GO_0042308) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "negative regulation of protein-nucleus import" + +- [negative regulation of protein import into nucleus](http://purl.obolibrary.org/obo/GO_0042308) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "inhibition of protein import into nucleus" + +- [negative regulation of protein import into nucleus](http://purl.obolibrary.org/obo/GO_0042308) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "downregulation of protein import into nucleus" + +- Class: [negative regulation of protein import into nucleus](http://purl.obolibrary.org/obo/GO_0042308) + +- [negative regulation of protein import into nucleus](http://purl.obolibrary.org/obo/GO_0042308) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([negatively regulates](http://purl.obolibrary.org/obo/RO_0002212) some [protein import into nucleus](http://purl.obolibrary.org/obo/GO_0006606)) + +- [negative regulation of protein import into nucleus](http://purl.obolibrary.org/obo/GO_0042308) SubClassOf [negative regulation of protein localization to nucleus](http://purl.obolibrary.org/obo/GO_1900181) + +- [negative regulation of protein import into nucleus](http://purl.obolibrary.org/obo/GO_0042308) SubClassOf [negatively regulates](http://purl.obolibrary.org/obo/RO_0002212) some [protein import into nucleus](http://purl.obolibrary.org/obo/GO_0006606) + +- [negative regulation of protein import into nucleus](http://purl.obolibrary.org/obo/GO_0042308) SubClassOf [negative regulation of nucleocytoplasmic transport](http://purl.obolibrary.org/obo/GO_0046823) + +- [negative regulation of protein import into nucleus](http://purl.obolibrary.org/obo/GO_0042308) SubClassOf [negative regulation of intracellular protein transport](http://purl.obolibrary.org/obo/GO_0090317) + +- [negative regulation of protein import into nucleus](http://purl.obolibrary.org/obo/GO_0042308) SubClassOf [regulation of protein import into nucleus](http://purl.obolibrary.org/obo/GO_0042306) + + +### negative regulation of protein serine/threonine kinase activity `http://purl.obolibrary.org/obo/GO_0071901` +#### Removed +- [negative regulation of protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0071901) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0071901" + +- [negative regulation of protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0071901) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2010-09-15T03:09:43Z" + +- [negative regulation of protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0071901) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "mah" + +- [negative regulation of protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0071901) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" + +- [negative regulation of protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0071901) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that decreases the rate, frequency, or extent of protein serine/threonine kinase activity." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:mah" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:BHF" + +- [negative regulation of protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0071901) [label](http://www.w3.org/2000/01/rdf-schema#label) "negative regulation of protein serine/threonine kinase activity" + +- [negative regulation of protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0071901) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate) + +- Class: [negative regulation of protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0071901) + +- [negative regulation of protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0071901) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([negatively regulates](http://purl.obolibrary.org/obo/RO_0002212) some [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674)) + +- [negative regulation of protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0071901) SubClassOf [negative regulation of protein kinase activity](http://purl.obolibrary.org/obo/GO_0006469) + +- [negative regulation of protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0071901) SubClassOf [negatively regulates](http://purl.obolibrary.org/obo/RO_0002212) some [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) + +- [negative regulation of protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0071901) SubClassOf [regulation of protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0071900) + + + +### negative regulation of release of sequestered calcium ion into cytosol `http://purl.obolibrary.org/obo/GO_0051280` + +#### Added +- [negative regulation of release of sequestered calcium ion into cytosol](http://purl.obolibrary.org/obo/GO_0051280) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "inhibition of release of sequestered calcium ion into cytosol" + +- [negative regulation of release of sequestered calcium ion into cytosol](http://purl.obolibrary.org/obo/GO_0051280) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" + +- [negative regulation of release of sequestered calcium ion into cytosol](http://purl.obolibrary.org/obo/GO_0051280) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "negative regulation of release of sequestered calcium ion (Ca2+)" + +- [negative regulation of release of sequestered calcium ion into cytosol](http://purl.obolibrary.org/obo/GO_0051280) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that stops, prevents, or reduces the frequency, rate or extent of the release into the cytosolic compartment of calcium ions sequestered in the endoplasmic reticulum or mitochondria." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:ai" + +- [negative regulation of release of sequestered calcium ion into cytosol](http://purl.obolibrary.org/obo/GO_0051280) [label](http://www.w3.org/2000/01/rdf-schema#label) "negative regulation of release of sequestered calcium ion into cytosol" + +- [negative regulation of release of sequestered calcium ion into cytosol](http://purl.obolibrary.org/obo/GO_0051280) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "down-regulation of release of sequestered calcium ion into cytosol" + +- [negative regulation of release of sequestered calcium ion into cytosol](http://purl.obolibrary.org/obo/GO_0051280) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "negative regulation of release of stored calcium ion (Ca2+) into cytosol" + +- [negative regulation of release of sequestered calcium ion into cytosol](http://purl.obolibrary.org/obo/GO_0051280) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "negative regulation of cytoplasmic release of stored calcium ion (Ca2+)" + +- [negative regulation of release of sequestered calcium ion into cytosol](http://purl.obolibrary.org/obo/GO_0051280) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "negative regulation of calcium ion (Ca2+) mobilization" + +- [negative regulation of release of sequestered calcium ion into cytosol](http://purl.obolibrary.org/obo/GO_0051280) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "down regulation of release of sequestered calcium ion into cytosol" + +- [negative regulation of release of sequestered calcium ion into cytosol](http://purl.obolibrary.org/obo/GO_0051280) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "negative regulation of cytoplasmic release of sequestered calcium ion (Ca2+)" + +- [negative regulation of release of sequestered calcium ion into cytosol](http://purl.obolibrary.org/obo/GO_0051280) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "negative regulation of release of stored calcium ion (Ca2+)" + +- [negative regulation of release of sequestered calcium ion into cytosol](http://purl.obolibrary.org/obo/GO_0051280) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "negative regulation of calcium mobilization" + +- [negative regulation of release of sequestered calcium ion into cytosol](http://purl.obolibrary.org/obo/GO_0051280) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "negative regulation of cytosolic release of stored calcium ion (Ca2+)" + +- [negative regulation of release of sequestered calcium ion into cytosol](http://purl.obolibrary.org/obo/GO_0051280) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "negative regulation of release of sequestered calcium ion into cytoplasm" + +- [negative regulation of release of sequestered calcium ion into cytosol](http://purl.obolibrary.org/obo/GO_0051280) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "negative regulation of cytosolic release of sequestered calcium ion (Ca2+)" + +- [negative regulation of release of sequestered calcium ion into cytosol](http://purl.obolibrary.org/obo/GO_0051280) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "downregulation of release of sequestered calcium ion into cytosol" + +- [negative regulation of release of sequestered calcium ion into cytosol](http://purl.obolibrary.org/obo/GO_0051280) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0051280" + +- [negative regulation of release of sequestered calcium ion into cytosol](http://purl.obolibrary.org/obo/GO_0051280) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "negative regulation of release of stored calcium ion (Ca2+) into cytoplasm" + +- Class: [negative regulation of release of sequestered calcium ion into cytosol](http://purl.obolibrary.org/obo/GO_0051280) + +- [negative regulation of release of sequestered calcium ion into cytosol](http://purl.obolibrary.org/obo/GO_0051280) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([negatively regulates](http://purl.obolibrary.org/obo/RO_0002212) some [release of sequestered calcium ion into cytosol](http://purl.obolibrary.org/obo/GO_0051209)) + +- [negative regulation of release of sequestered calcium ion into cytosol](http://purl.obolibrary.org/obo/GO_0051280) SubClassOf [negatively regulates](http://purl.obolibrary.org/obo/RO_0002212) some [release of sequestered calcium ion into cytosol](http://purl.obolibrary.org/obo/GO_0051209) + +- [negative regulation of release of sequestered calcium ion into cytosol](http://purl.obolibrary.org/obo/GO_0051280) SubClassOf [negative regulation of calcium ion transmembrane transport](http://purl.obolibrary.org/obo/GO_1903170) + +- [negative regulation of release of sequestered calcium ion into cytosol](http://purl.obolibrary.org/obo/GO_0051280) SubClassOf [regulation of release of sequestered calcium ion into cytosol](http://purl.obolibrary.org/obo/GO_0051279) + +- [negative regulation of release of sequestered calcium ion into cytosol](http://purl.obolibrary.org/obo/GO_0051280) SubClassOf [positive regulation of sequestering of calcium ion](http://purl.obolibrary.org/obo/GO_0051284) + + +### negative regulation of retrograde dense core granule transport `http://purl.obolibrary.org/obo/GO_1901955` + +#### Added +- [negative regulation of retrograde dense core granule transport](http://purl.obolibrary.org/obo/GO_1901955) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "down-regulation of retrograde dense core granule transport" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of retrograde dense core granule transport](http://purl.obolibrary.org/obo/GO_1901955) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "down regulation of retrograde dense core granule transport" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of retrograde dense core granule transport](http://purl.obolibrary.org/obo/GO_1901955) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" + +- [negative regulation of retrograde dense core granule transport](http://purl.obolibrary.org/obo/GO_1901955) [label](http://www.w3.org/2000/01/rdf-schema#label) "negative regulation of retrograde dense core granule transport" + +- [negative regulation of retrograde dense core granule transport](http://purl.obolibrary.org/obo/GO_1901955) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that stops, prevents or reduces the frequency, rate or extent of retrograde dense core granule transport." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:23358451" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:kmv" + +- [negative regulation of retrograde dense core granule transport](http://purl.obolibrary.org/obo/GO_1901955) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "pr" + +- [negative regulation of retrograde dense core granule transport](http://purl.obolibrary.org/obo/GO_1901955) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:1901955" + +- [negative regulation of retrograde dense core granule transport](http://purl.obolibrary.org/obo/GO_1901955) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "downregulation of retrograde dense core granule transport" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [negative regulation of retrograde dense core granule transport](http://purl.obolibrary.org/obo/GO_1901955) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2013-02-19T13:36:47Z" + +- [negative regulation of retrograde dense core granule transport](http://purl.obolibrary.org/obo/GO_1901955) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "inhibition of retrograde dense core granule transport" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- Class: [negative regulation of retrograde dense core granule transport](http://purl.obolibrary.org/obo/GO_1901955) + +- [negative regulation of retrograde dense core granule transport](http://purl.obolibrary.org/obo/GO_1901955) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([negatively regulates](http://purl.obolibrary.org/obo/RO_0002212) some [retrograde neuronal dense core vesicle transport](http://purl.obolibrary.org/obo/GO_1990049)) + +- [negative regulation of retrograde dense core granule transport](http://purl.obolibrary.org/obo/GO_1901955) SubClassOf [negative regulation of dense core granule transport](http://purl.obolibrary.org/obo/GO_1904810) + +- [negative regulation of retrograde dense core granule transport](http://purl.obolibrary.org/obo/GO_1901955) SubClassOf [negative regulation of retrograde axon cargo transport](http://purl.obolibrary.org/obo/GO_2001018) + +- [negative regulation of retrograde dense core granule transport](http://purl.obolibrary.org/obo/GO_1901955) SubClassOf [negatively regulates](http://purl.obolibrary.org/obo/RO_0002212) some [retrograde neuronal dense core vesicle transport](http://purl.obolibrary.org/obo/GO_1990049) + +- [negative regulation of retrograde dense core granule transport](http://purl.obolibrary.org/obo/GO_1901955) SubClassOf [negative regulation of vesicle transport along microtubule](http://purl.obolibrary.org/obo/GO_1901609) + +- [negative regulation of retrograde dense core granule transport](http://purl.obolibrary.org/obo/GO_1901955) SubClassOf [regulation of retrograde dense core granule transport](http://purl.obolibrary.org/obo/GO_1901954) + + +### negative regulation of sequestering of calcium ion `http://purl.obolibrary.org/obo/GO_0051283` + +#### Added +- [negative regulation of sequestering of calcium ion](http://purl.obolibrary.org/obo/GO_0051283) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "negative regulation of storage of calcium ion (Ca2+)" + +- [negative regulation of sequestering of calcium ion](http://purl.obolibrary.org/obo/GO_0051283) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "negative regulation of sequestering of calcium ion (Ca2+)" + +- [negative regulation of sequestering of calcium ion](http://purl.obolibrary.org/obo/GO_0051283) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that stops, prevents, or reduces the frequency, rate or extent of the binding or confining calcium ions such that they are separated from other components of a biological system." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:ai" + +- [negative regulation of sequestering of calcium ion](http://purl.obolibrary.org/obo/GO_0051283) [label](http://www.w3.org/2000/01/rdf-schema#label) "negative regulation of sequestering of calcium ion" + +- [negative regulation of sequestering of calcium ion](http://purl.obolibrary.org/obo/GO_0051283) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "down regulation of sequestering of calcium ion" + +- [negative regulation of sequestering of calcium ion](http://purl.obolibrary.org/obo/GO_0051283) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "negative regulation of calcium ion (Ca2+) sequestering" + +- [negative regulation of sequestering of calcium ion](http://purl.obolibrary.org/obo/GO_0051283) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "negative regulation of sequestration of calcium ion (Ca2+)" + +- [negative regulation of sequestering of calcium ion](http://purl.obolibrary.org/obo/GO_0051283) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "down-regulation of sequestering of calcium ion" + +- [negative regulation of sequestering of calcium ion](http://purl.obolibrary.org/obo/GO_0051283) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "negative regulation of retention of calcium ion (Ca2+)" + +- [negative regulation of sequestering of calcium ion](http://purl.obolibrary.org/obo/GO_0051283) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0051283" + +- [negative regulation of sequestering of calcium ion](http://purl.obolibrary.org/obo/GO_0051283) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "negative regulation of calcium ion (Ca2+) storage" + +- [negative regulation of sequestering of calcium ion](http://purl.obolibrary.org/obo/GO_0051283) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "inhibition of sequestering of calcium ion" + +- [negative regulation of sequestering of calcium ion](http://purl.obolibrary.org/obo/GO_0051283) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "negative regulation of calcium ion (Ca2+) sequestration" + +- [negative regulation of sequestering of calcium ion](http://purl.obolibrary.org/obo/GO_0051283) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" + +- [negative regulation of sequestering of calcium ion](http://purl.obolibrary.org/obo/GO_0051283) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "downregulation of sequestering of calcium ion" + +- [negative regulation of sequestering of calcium ion](http://purl.obolibrary.org/obo/GO_0051283) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "negative regulation of calcium ion (Ca2+) retention" + +- Class: [negative regulation of sequestering of calcium ion](http://purl.obolibrary.org/obo/GO_0051283) + +- [negative regulation of sequestering of calcium ion](http://purl.obolibrary.org/obo/GO_0051283) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([negatively regulates](http://purl.obolibrary.org/obo/RO_0002212) some [sequestering of calcium ion](http://purl.obolibrary.org/obo/GO_0051208)) + +- [negative regulation of sequestering of calcium ion](http://purl.obolibrary.org/obo/GO_0051283) SubClassOf [negatively regulates](http://purl.obolibrary.org/obo/RO_0002212) some [sequestering of calcium ion](http://purl.obolibrary.org/obo/GO_0051208) + +- [negative regulation of sequestering of calcium ion](http://purl.obolibrary.org/obo/GO_0051283) SubClassOf [regulation of sequestering of calcium ion](http://purl.obolibrary.org/obo/GO_0051282) + +- [negative regulation of sequestering of calcium ion](http://purl.obolibrary.org/obo/GO_0051283) SubClassOf [negative regulation of cellular process](http://purl.obolibrary.org/obo/GO_0048523) + + +### negative regulation of translation `http://purl.obolibrary.org/obo/GO_0017148` +#### Removed +- [negative regulation of translation](http://purl.obolibrary.org/obo/GO_0017148) SubClassOf [negative regulation of macromolecule biosynthetic process](http://purl.obolibrary.org/obo/GO_0010558) + + + +### negative regulation of translational initiation `http://purl.obolibrary.org/obo/GO_0045947` +#### Removed +- [negative regulation of translational initiation](http://purl.obolibrary.org/obo/GO_0045947) SubClassOf [negative regulation of cellular metabolic process](http://purl.obolibrary.org/obo/GO_0031324) + + + +### neuron `http://purl.obolibrary.org/obo/CL_0000540` + +#### Added +- [neuron](http://purl.obolibrary.org/obo/CL_0000540) [depicted by](http://xmlns.com/foaf/0.1/depicted_by) "https://www.swissbiopics.org/api/image/Neuron_cells.svg"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI) + + +### neuron apoptotic process `http://purl.obolibrary.org/obo/GO_0051402` +#### Removed +- [neuron apoptotic process](http://purl.obolibrary.org/obo/GO_0051402) SubClassOf [neuron death](http://purl.obolibrary.org/obo/GO_0070997) + +#### Added +- [neuron apoptotic process](http://purl.obolibrary.org/obo/GO_0051402) SubClassOf [occurs in](http://purl.obolibrary.org/obo/BFO_0000066) some [neuron](http://purl.obolibrary.org/obo/CL_0000540) + + +### neuron death `http://purl.obolibrary.org/obo/GO_0070997` +#### Removed +- [neuron death](http://purl.obolibrary.org/obo/GO_0070997) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "mah" + +- [neuron death](http://purl.obolibrary.org/obo/GO_0070997) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The process of cell death in a neuron." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:mah" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:BHF" + +- [neuron death](http://purl.obolibrary.org/obo/GO_0070997) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2009-11-03T02:37:17Z" + +- [neuron death](http://purl.obolibrary.org/obo/GO_0070997) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" + +- [neuron death](http://purl.obolibrary.org/obo/GO_0070997) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "neuron cell death" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:mah" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:rl" + +- [neuron death](http://purl.obolibrary.org/obo/GO_0070997) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "neuronal cell death" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:mah" + +- [neuron death](http://purl.obolibrary.org/obo/GO_0070997) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "This term should not be used for direct annotation. The only exception should be when experimental data (e.g., staining with trypan blue or propidium iodide or use of neuron-specific markers) show that neuron death has occurred, but fail to provide details on death modality (accidental versus programmed). When information is provided on the neuron death mechanism, annotations should be made to the appropriate descendant of 'cell death' (such as, but not limited to, GO:0097300 'programmed necrotic cell death' or GO:0006915 'apoptotic process'), and the cell type captured as an annotation extension; or the term GO:0051402 'neuron apoptotic process' may be considered, if appropriate." + +- [neuron death](http://purl.obolibrary.org/obo/GO_0070997) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0070997" + +- [neuron death](http://purl.obolibrary.org/obo/GO_0070997) [label](http://www.w3.org/2000/01/rdf-schema#label) "neuron death" + +- Class: [neuron death](http://purl.obolibrary.org/obo/GO_0070997) + +- [neuron death](http://purl.obolibrary.org/obo/GO_0070997) EquivalentTo [cell death](http://purl.obolibrary.org/obo/GO_0008219) and ([occurs in](http://purl.obolibrary.org/obo/BFO_0000066) some [neuron](http://purl.obolibrary.org/obo/CL_0000540)) + +- [neuron death](http://purl.obolibrary.org/obo/GO_0070997) SubClassOf [cell death](http://purl.obolibrary.org/obo/GO_0008219) + +- [neuron death](http://purl.obolibrary.org/obo/GO_0070997) SubClassOf [occurs in](http://purl.obolibrary.org/obo/BFO_0000066) some [neuron](http://purl.obolibrary.org/obo/CL_0000540) + + + +### neuron-glial cell signaling `http://purl.obolibrary.org/obo/GO_0150099` +#### Removed +- [neuron-glial cell signaling](http://purl.obolibrary.org/obo/GO_0150099) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Cell-cell signaling that mediates the transfer of information from a neuron to a glial cell. This signalling has been shown to be mediated by various molecules released by different types of neurons, e.g. glutamate, gamma-amino butyric acid (GABA), noradrenaline, acetylcholine, dopamine and adenosine." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:11356870" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:15252819" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:27788368" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:10195197" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:10377338" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:10196584" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:bc" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:10493741" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:11399439" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:aruk" + +#### Added +- [neuron-glial cell signaling](http://purl.obolibrary.org/obo/GO_0150099) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Cell-cell signaling that mediates the transfer of information from a neuron to a glial cell. This signaling has been shown to be mediated by various molecules released by different types of neurons, e.g. glutamate, gamma-amino butyric acid (GABA), noradrenaline, acetylcholine, dopamine and adenosine." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:11356870" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:15252819" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:27788368" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:10195197" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:10377338" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:10196584" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:bc" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:10493741" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:11399439" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:aruk" + + +### neuronal dense core vesicle `http://purl.obolibrary.org/obo/GO_0098992` + +#### Added +- [neuronal dense core vesicle](http://purl.obolibrary.org/obo/GO_0098992) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0098992" + +- [neuronal dense core vesicle](http://purl.obolibrary.org/obo/GO_0098992) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [goslim_synapse](http://purl.obolibrary.org/obo/go#goslim_synapse) + +- [neuronal dense core vesicle](http://purl.obolibrary.org/obo/GO_0098992) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "cellular_component" + +- [neuronal dense core vesicle](http://purl.obolibrary.org/obo/GO_0098992) [label](http://www.w3.org/2000/01/rdf-schema#label) "neuronal dense core vesicle" + +- [neuronal dense core vesicle](http://purl.obolibrary.org/obo/GO_0098992) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A dense core vesicle (granule) that is part of a neuron. These vesicles typically contain neuropeptides. They can be found in all parts of neurons, including the soma, dendrites, axonal swellings (varicosities) and synaptic terminals." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dos" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ISBN:978-0-07-181001-2" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Wikipedia:Neuropeptide&oldid=713905176" + +- Class: [neuronal dense core vesicle](http://purl.obolibrary.org/obo/GO_0098992) + +- [neuronal dense core vesicle](http://purl.obolibrary.org/obo/GO_0098992) EquivalentTo [dense core granule](http://purl.obolibrary.org/obo/GO_0031045) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [neuron](http://purl.obolibrary.org/obo/CL_0000540)) + +- [neuronal dense core vesicle](http://purl.obolibrary.org/obo/GO_0098992) SubClassOf [dense core granule](http://purl.obolibrary.org/obo/GO_0031045) + +- [neuronal dense core vesicle](http://purl.obolibrary.org/obo/GO_0098992) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [neuron](http://purl.obolibrary.org/obo/CL_0000540) + + +### neuronal dense core vesicle membrane `http://purl.obolibrary.org/obo/GO_0099012` + +#### Added +- [neuronal dense core vesicle membrane](http://purl.obolibrary.org/obo/GO_0099012) [label](http://www.w3.org/2000/01/rdf-schema#label) "neuronal dense core vesicle membrane" + +- [neuronal dense core vesicle membrane](http://purl.obolibrary.org/obo/GO_0099012) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0099012" + +- [neuronal dense core vesicle membrane](http://purl.obolibrary.org/obo/GO_0099012) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [goslim_synapse](http://purl.obolibrary.org/obo/go#goslim_synapse) + +- [neuronal dense core vesicle membrane](http://purl.obolibrary.org/obo/GO_0099012) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "cellular_component" + +- [neuronal dense core vesicle membrane](http://purl.obolibrary.org/obo/GO_0099012) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The lipid bilayer surrounding a neuronal dense core vesicle." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dos" + +- Class: [neuronal dense core vesicle membrane](http://purl.obolibrary.org/obo/GO_0099012) + +- [neuronal dense core vesicle membrane](http://purl.obolibrary.org/obo/GO_0099012) EquivalentTo [membrane](http://purl.obolibrary.org/obo/GO_0016020) and ([bounding layer of](http://purl.obolibrary.org/obo/RO_0002007) some [neuronal dense core vesicle](http://purl.obolibrary.org/obo/GO_0098992)) + +- [neuronal dense core vesicle membrane](http://purl.obolibrary.org/obo/GO_0099012) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [neuronal dense core vesicle](http://purl.obolibrary.org/obo/GO_0098992) + +- [neuronal dense core vesicle membrane](http://purl.obolibrary.org/obo/GO_0099012) SubClassOf [dense core granule membrane](http://purl.obolibrary.org/obo/GO_0032127) + +- [neuronal dense core vesicle membrane](http://purl.obolibrary.org/obo/GO_0099012) SubClassOf [bounding layer of](http://purl.obolibrary.org/obo/RO_0002007) some [neuronal dense core vesicle](http://purl.obolibrary.org/obo/GO_0098992) + + +### neuronal dense core vesicle organization `http://purl.obolibrary.org/obo/GO_0099014` + +#### Added +- [neuronal dense core vesicle organization](http://purl.obolibrary.org/obo/GO_0099014) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0099014" + +- [neuronal dense core vesicle organization](http://purl.obolibrary.org/obo/GO_0099014) [label](http://www.w3.org/2000/01/rdf-schema#label) "neuronal dense core vesicle organization" + +- [neuronal dense core vesicle organization](http://purl.obolibrary.org/obo/GO_0099014) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" + +- [neuronal dense core vesicle organization](http://purl.obolibrary.org/obo/GO_0099014) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuronal dense core vesicle." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dos" + +- Class: [neuronal dense core vesicle organization](http://purl.obolibrary.org/obo/GO_0099014) + +- [neuronal dense core vesicle organization](http://purl.obolibrary.org/obo/GO_0099014) EquivalentTo [cellular component organization](http://purl.obolibrary.org/obo/GO_0016043) and ([results in organization of](http://purl.obolibrary.org/obo/RO_0002592) some [neuronal dense core vesicle](http://purl.obolibrary.org/obo/GO_0098992)) + +- [neuronal dense core vesicle organization](http://purl.obolibrary.org/obo/GO_0099014) SubClassOf [results in organization of](http://purl.obolibrary.org/obo/RO_0002592) some [neuronal dense core vesicle](http://purl.obolibrary.org/obo/GO_0098992) + +- [neuronal dense core vesicle organization](http://purl.obolibrary.org/obo/GO_0099014) SubClassOf [dense core granule organization](http://purl.obolibrary.org/obo/GO_0061109) + + +### neurotransmitter metabolic process `http://purl.obolibrary.org/obo/GO_0042133` +#### Removed +- [neurotransmitter metabolic process](http://purl.obolibrary.org/obo/GO_0042133) SubClassOf [regulation of neurotransmitter levels](http://purl.obolibrary.org/obo/GO_0001505) + + + +### neurotransmitter uptake `http://purl.obolibrary.org/obo/GO_0001504` + +#### Added +- [neurotransmitter uptake](http://purl.obolibrary.org/obo/GO_0001504) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The directed movement of neurotransmitters into neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ISBN:0123668387" + +- [neurotransmitter uptake](http://purl.obolibrary.org/obo/GO_0001504) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" + +- [neurotransmitter uptake](http://purl.obolibrary.org/obo/GO_0001504) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "neurotransmitter recycling" + +- [neurotransmitter uptake](http://purl.obolibrary.org/obo/GO_0001504) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0001504" + +- [neurotransmitter uptake](http://purl.obolibrary.org/obo/GO_0001504) [label](http://www.w3.org/2000/01/rdf-schema#label) "neurotransmitter uptake" + +- [neurotransmitter uptake](http://purl.obolibrary.org/obo/GO_0001504) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "neurotransmitter import into neuron" + +- [neurotransmitter uptake](http://purl.obolibrary.org/obo/GO_0001504) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "neurotransmitter import into glial cell" + +- [neurotransmitter uptake](http://purl.obolibrary.org/obo/GO_0001504) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "neurotransmitter import" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dph" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:tb" + +- [neurotransmitter uptake](http://purl.obolibrary.org/obo/GO_0001504) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [goslim_synapse](http://purl.obolibrary.org/obo/go#goslim_synapse) + +- Class: [neurotransmitter uptake](http://purl.obolibrary.org/obo/GO_0001504) + +- [neurotransmitter uptake](http://purl.obolibrary.org/obo/GO_0001504) SubClassOf [neurotransmitter transport](http://purl.obolibrary.org/obo/GO_0006836) + +- [neurotransmitter uptake](http://purl.obolibrary.org/obo/GO_0001504) SubClassOf [regulation of neurotransmitter levels](http://purl.obolibrary.org/obo/GO_0001505) + + +### neutral amino acid transmembrane export from vacuole `http://purl.obolibrary.org/obo/GO_0034489` + +#### Added +- [neutral amino acid transmembrane export from vacuole](http://purl.obolibrary.org/obo/GO_0034489) [label](http://www.w3.org/2000/01/rdf-schema#label) "neutral amino acid transmembrane export from vacuole" + +- [neutral amino acid transmembrane export from vacuole](http://purl.obolibrary.org/obo/GO_0034489) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The directed movement of neutral amino acids out of the vacuole, across the vacuolar membrane." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:mah" + +- [neutral amino acid transmembrane export from vacuole](http://purl.obolibrary.org/obo/GO_0034489) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0034489" + +- [neutral amino acid transmembrane export from vacuole](http://purl.obolibrary.org/obo/GO_0034489) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" + +- Class: [neutral amino acid transmembrane export from vacuole](http://purl.obolibrary.org/obo/GO_0034489) + +- [neutral amino acid transmembrane export from vacuole](http://purl.obolibrary.org/obo/GO_0034489) EquivalentTo [neutral amino acid transport](http://purl.obolibrary.org/obo/GO_0015804) and ([has target start location](http://purl.obolibrary.org/obo/RO_0002338) some [vacuolar lumen](http://purl.obolibrary.org/obo/GO_0005775)) and ([has target end location](http://purl.obolibrary.org/obo/RO_0002339) some [cytosol](http://purl.obolibrary.org/obo/GO_0005829)) and ([results in transport across](http://purl.obolibrary.org/obo/RO_0002342) some [membrane](http://purl.obolibrary.org/obo/GO_0016020)) and ([has primary input](http://purl.obolibrary.org/obo/RO_0004009) some [CHEBI_33709](http://purl.obolibrary.org/obo/CHEBI_33709)) + +- [neutral amino acid transmembrane export from vacuole](http://purl.obolibrary.org/obo/GO_0034489) SubClassOf [neutral amino acid transport](http://purl.obolibrary.org/obo/GO_0015804) + +- [neutral amino acid transmembrane export from vacuole](http://purl.obolibrary.org/obo/GO_0034489) SubClassOf [amino acid transmembrane export from vacuole](http://purl.obolibrary.org/obo/GO_0032974) + + +### neutral amino acid transmembrane import into vacuole `http://purl.obolibrary.org/obo/GO_0034491` + +#### Added +- [neutral amino acid transmembrane import into vacuole](http://purl.obolibrary.org/obo/GO_0034491) [label](http://www.w3.org/2000/01/rdf-schema#label) "neutral amino acid transmembrane import into vacuole" + +- [neutral amino acid transmembrane import into vacuole](http://purl.obolibrary.org/obo/GO_0034491) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" + +- [neutral amino acid transmembrane import into vacuole](http://purl.obolibrary.org/obo/GO_0034491) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The directed movement of neutral amino acids into the vacuole across the vacuolar membrane." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:mah" + +- [neutral amino acid transmembrane import into vacuole](http://purl.obolibrary.org/obo/GO_0034491) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0034491" + +- Class: [neutral amino acid transmembrane import into vacuole](http://purl.obolibrary.org/obo/GO_0034491) + +- [neutral amino acid transmembrane import into vacuole](http://purl.obolibrary.org/obo/GO_0034491) EquivalentTo [neutral amino acid transport](http://purl.obolibrary.org/obo/GO_0015804) and ([has target start location](http://purl.obolibrary.org/obo/RO_0002338) some [cytosol](http://purl.obolibrary.org/obo/GO_0005829)) and ([has target end location](http://purl.obolibrary.org/obo/RO_0002339) some [vacuolar lumen](http://purl.obolibrary.org/obo/GO_0005775)) and ([results in transport across](http://purl.obolibrary.org/obo/RO_0002342) some [membrane](http://purl.obolibrary.org/obo/GO_0016020)) and ([has primary input](http://purl.obolibrary.org/obo/RO_0004009) some [CHEBI_33709](http://purl.obolibrary.org/obo/CHEBI_33709)) + +- [neutral amino acid transmembrane import into vacuole](http://purl.obolibrary.org/obo/GO_0034491) SubClassOf [amino acid transmembrane import into vacuole](http://purl.obolibrary.org/obo/GO_0032975) + +- [neutral amino acid transmembrane import into vacuole](http://purl.obolibrary.org/obo/GO_0034491) SubClassOf [neutral amino acid transport](http://purl.obolibrary.org/obo/GO_0015804) + + +### notochord regression `http://purl.obolibrary.org/obo/GO_0060032` +#### Removed +- [notochord regression](http://purl.obolibrary.org/obo/GO_0060032) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The developmental process in which the stucture of the notochord is destroyed in an embryo." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dph" + +- [notochord regression](http://purl.obolibrary.org/obo/GO_0060032) [label](http://www.w3.org/2000/01/rdf-schema#label) "notochord regression" + +- [notochord regression](http://purl.obolibrary.org/obo/GO_0060032) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" + +- [notochord regression](http://purl.obolibrary.org/obo/GO_0060032) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0060032" + +- Class: [notochord regression](http://purl.obolibrary.org/obo/GO_0060032) + +- [notochord regression](http://purl.obolibrary.org/obo/GO_0060032) EquivalentTo [anatomical structure regression](http://purl.obolibrary.org/obo/GO_0060033) and ([has input](http://purl.obolibrary.org/obo/RO_0002233) some [notochord](http://purl.obolibrary.org/obo/UBERON_0002328)) + +- [notochord regression](http://purl.obolibrary.org/obo/GO_0060032) SubClassOf [has input](http://purl.obolibrary.org/obo/RO_0002233) some [notochord](http://purl.obolibrary.org/obo/UBERON_0002328) + +- [notochord regression](http://purl.obolibrary.org/obo/GO_0060032) SubClassOf [anatomical structure regression](http://purl.obolibrary.org/obo/GO_0060033) + +- [notochord regression](http://purl.obolibrary.org/obo/GO_0060032) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [notochord morphogenesis](http://purl.obolibrary.org/obo/GO_0048570) + + + +### nuclear export `http://purl.obolibrary.org/obo/GO_0051168` + +#### Added +- [nuclear export](http://purl.obolibrary.org/obo/GO_0051168) [label](http://www.w3.org/2000/01/rdf-schema#label) "nuclear export" + +- [nuclear export](http://purl.obolibrary.org/obo/GO_0051168) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "export from nucleus" + +- [nuclear export](http://purl.obolibrary.org/obo/GO_0051168) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "nucleus export" + +- [nuclear export](http://purl.obolibrary.org/obo/GO_0051168) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The directed movement of substances out of the nucleus." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:ai" + +- [nuclear export](http://purl.obolibrary.org/obo/GO_0051168) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" + +- [nuclear export](http://purl.obolibrary.org/obo/GO_0051168) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0051168" + +- [nuclear export](http://purl.obolibrary.org/obo/GO_0051168) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "substance nuclear export" + +- Class: [nuclear export](http://purl.obolibrary.org/obo/GO_0051168) + +- [nuclear export](http://purl.obolibrary.org/obo/GO_0051168) EquivalentTo [transport](http://purl.obolibrary.org/obo/GO_0006810) and ([has target start location](http://purl.obolibrary.org/obo/RO_0002338) some [nuclear lumen](http://purl.obolibrary.org/obo/GO_0031981)) and ([has target end location](http://purl.obolibrary.org/obo/RO_0002339) some [cytosol](http://purl.obolibrary.org/obo/GO_0005829)) and ([results in transport across](http://purl.obolibrary.org/obo/RO_0002342) some [nuclear envelope](http://purl.obolibrary.org/obo/GO_0005635)) + +- [nuclear export](http://purl.obolibrary.org/obo/GO_0051168) SubClassOf [has target start location](http://purl.obolibrary.org/obo/RO_0002338) some [nuclear lumen](http://purl.obolibrary.org/obo/GO_0031981) + +- [nuclear export](http://purl.obolibrary.org/obo/GO_0051168) SubClassOf [nucleocytoplasmic transport](http://purl.obolibrary.org/obo/GO_0006913) + +- [nuclear export](http://purl.obolibrary.org/obo/GO_0051168) SubClassOf [has target end location](http://purl.obolibrary.org/obo/RO_0002339) some [cytosol](http://purl.obolibrary.org/obo/GO_0005829) + + +### nucleocytoplasmic transport `http://purl.obolibrary.org/obo/GO_0006913` + +#### Added +- [nucleocytoplasmic transport](http://purl.obolibrary.org/obo/GO_0006913) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" + +- [nucleocytoplasmic transport](http://purl.obolibrary.org/obo/GO_0006913) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [goslim_generic](http://purl.obolibrary.org/obo/go#goslim_generic) + +- [nucleocytoplasmic transport](http://purl.obolibrary.org/obo/GO_0006913) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "Note that transport through the nuclear pore complex is not transmembrane because the nuclear membrane is a double membrane, and is not traversed." + +- [nucleocytoplasmic transport](http://purl.obolibrary.org/obo/GO_0006913) [has_alternative_id](http://www.geneontology.org/formats/oboInOwl#hasAlternativeId) "GO:0000063" + +- [nucleocytoplasmic transport](http://purl.obolibrary.org/obo/GO_0006913) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [goslim_pombe](http://purl.obolibrary.org/obo/go#goslim_pombe) + +- [nucleocytoplasmic transport](http://purl.obolibrary.org/obo/GO_0006913) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [goslim_drosophila](http://purl.obolibrary.org/obo/go#goslim_drosophila) + +- [nucleocytoplasmic transport](http://purl.obolibrary.org/obo/GO_0006913) [label](http://www.w3.org/2000/01/rdf-schema#label) "nucleocytoplasmic transport" + +- [nucleocytoplasmic transport](http://purl.obolibrary.org/obo/GO_0006913) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "nucleocytoplasmic shuttling" + +- [nucleocytoplasmic transport](http://purl.obolibrary.org/obo/GO_0006913) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0006913" + +- [nucleocytoplasmic transport](http://purl.obolibrary.org/obo/GO_0006913) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The directed movement of molecules between the nucleus and the cytoplasm." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:go_curators" + +- [nucleocytoplasmic transport](http://purl.obolibrary.org/obo/GO_0006913) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [goslim_chembl](http://purl.obolibrary.org/obo/go#goslim_chembl) + +- Class: [nucleocytoplasmic transport](http://purl.obolibrary.org/obo/GO_0006913) + +- [nucleocytoplasmic transport](http://purl.obolibrary.org/obo/GO_0006913) EquivalentTo [transport](http://purl.obolibrary.org/obo/GO_0006810) and ([results in transport across](http://purl.obolibrary.org/obo/RO_0002342) some [nuclear envelope](http://purl.obolibrary.org/obo/GO_0005635)) and ([results in transport to from or in](http://purl.obolibrary.org/obo/RO_0002344) some [cytosol](http://purl.obolibrary.org/obo/GO_0005829)) and ([results in transport to from or in](http://purl.obolibrary.org/obo/RO_0002344) some [nuclear lumen](http://purl.obolibrary.org/obo/GO_0031981)) + +- [nucleocytoplasmic transport](http://purl.obolibrary.org/obo/GO_0006913) SubClassOf [results in transport to from or in](http://purl.obolibrary.org/obo/RO_0002344) some [cytosol](http://purl.obolibrary.org/obo/GO_0005829) + +- [nucleocytoplasmic transport](http://purl.obolibrary.org/obo/GO_0006913) SubClassOf [nuclear transport](http://purl.obolibrary.org/obo/GO_0051169) + +- [nucleocytoplasmic transport](http://purl.obolibrary.org/obo/GO_0006913) SubClassOf [results in transport to from or in](http://purl.obolibrary.org/obo/RO_0002344) some [nuclear lumen](http://purl.obolibrary.org/obo/GO_0031981) + +- [nucleocytoplasmic transport](http://purl.obolibrary.org/obo/GO_0006913) SubClassOf [results in transport across](http://purl.obolibrary.org/obo/RO_0002342) some [nuclear envelope](http://purl.obolibrary.org/obo/GO_0005635) + + +### nucleophagy `http://purl.obolibrary.org/obo/GO_0044804` +#### Removed +- [nucleophagy](http://purl.obolibrary.org/obo/GO_0044804) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2013-09-10T15:50:25Z" + +- [nucleophagy](http://purl.obolibrary.org/obo/GO_0044804) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "jl" + +- [nucleophagy](http://purl.obolibrary.org/obo/GO_0044804) [label](http://www.w3.org/2000/01/rdf-schema#label) "nucleophagy" + +- [nucleophagy](http://purl.obolibrary.org/obo/GO_0044804) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0044804" + +- [nucleophagy](http://purl.obolibrary.org/obo/GO_0044804) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "nucleus degradation" + +- [nucleophagy](http://purl.obolibrary.org/obo/GO_0044804) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A form of autophagy, by which damaged or non-essential parts of the nucleus, or even an entire nucleus is degraded." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:jl" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:autophagy" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:24013549" + +- [nucleophagy](http://purl.obolibrary.org/obo/GO_0044804) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" + +- [nucleophagy](http://purl.obolibrary.org/obo/GO_0044804) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "autophagy of nucleus" + +- Class: [nucleophagy](http://purl.obolibrary.org/obo/GO_0044804) + +- [nucleophagy](http://purl.obolibrary.org/obo/GO_0044804) EquivalentTo [autophagy](http://purl.obolibrary.org/obo/GO_0006914) and ([has input](http://purl.obolibrary.org/obo/RO_0002233) some [nucleus](http://purl.obolibrary.org/obo/GO_0005634)) + +- [nucleophagy](http://purl.obolibrary.org/obo/GO_0044804) SubClassOf [autophagy](http://purl.obolibrary.org/obo/GO_0006914) + +- [nucleophagy](http://purl.obolibrary.org/obo/GO_0044804) SubClassOf [has input](http://purl.obolibrary.org/obo/RO_0002233) some [nucleus](http://purl.obolibrary.org/obo/GO_0005634) + + + +### nucleoside diphosphate biosynthetic process `http://purl.obolibrary.org/obo/GO_0009133` +#### Removed +- [nucleoside diphosphate biosynthetic process](http://purl.obolibrary.org/obo/GO_0009133) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "nucleoside diphosphate anabolism" + +- [nucleoside diphosphate biosynthetic process](http://purl.obolibrary.org/obo/GO_0009133) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0009133" + +- [nucleoside diphosphate biosynthetic process](http://purl.obolibrary.org/obo/GO_0009133) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" + +- [nucleoside diphosphate biosynthetic process](http://purl.obolibrary.org/obo/GO_0009133) [label](http://www.w3.org/2000/01/rdf-schema#label) "nucleoside diphosphate biosynthetic process" + +- [nucleoside diphosphate biosynthetic process](http://purl.obolibrary.org/obo/GO_0009133) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "nucleoside diphosphate formation" + +- [nucleoside diphosphate biosynthetic process](http://purl.obolibrary.org/obo/GO_0009133) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "nucleoside diphosphate biosynthesis" + +- [nucleoside diphosphate biosynthetic process](http://purl.obolibrary.org/obo/GO_0009133) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The chemical reactions and pathways resulting in the formation of a nucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with diphosphate on the sugar." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:go_curators" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ISBN:0198506732" + +- [nucleoside diphosphate biosynthetic process](http://purl.obolibrary.org/obo/GO_0009133) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "nucleoside diphosphate synthesis" + +- Class: [nucleoside diphosphate biosynthetic process](http://purl.obolibrary.org/obo/GO_0009133) + +- [nucleoside diphosphate biosynthetic process](http://purl.obolibrary.org/obo/GO_0009133) EquivalentTo [biosynthetic process](http://purl.obolibrary.org/obo/GO_0009058) and ([has primary output](http://purl.obolibrary.org/obo/RO_0004008) some [CHEBI_57930](http://purl.obolibrary.org/obo/CHEBI_57930)) + +- [nucleoside diphosphate biosynthetic process](http://purl.obolibrary.org/obo/GO_0009133) SubClassOf [biosynthetic process](http://purl.obolibrary.org/obo/GO_0009058) + +- [nucleoside diphosphate biosynthetic process](http://purl.obolibrary.org/obo/GO_0009133) SubClassOf [nucleoside diphosphate metabolic process](http://purl.obolibrary.org/obo/GO_0009132) + +- [nucleoside diphosphate biosynthetic process](http://purl.obolibrary.org/obo/GO_0009133) SubClassOf [has primary output](http://purl.obolibrary.org/obo/RO_0004008) some [CHEBI_57930](http://purl.obolibrary.org/obo/CHEBI_57930) + + + +### nucleoside diphosphate catabolic process `http://purl.obolibrary.org/obo/GO_0009134` +#### Removed +- [nucleoside diphosphate catabolic process](http://purl.obolibrary.org/obo/GO_0009134) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0009134" + +- [nucleoside diphosphate catabolic process](http://purl.obolibrary.org/obo/GO_0009134) [label](http://www.w3.org/2000/01/rdf-schema#label) "nucleoside diphosphate catabolic process" + +- [nucleoside diphosphate catabolic process](http://purl.obolibrary.org/obo/GO_0009134) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "nucleoside diphosphate degradation" + +- [nucleoside diphosphate catabolic process](http://purl.obolibrary.org/obo/GO_0009134) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "nucleoside diphosphate catabolism" + +- [nucleoside diphosphate catabolic process](http://purl.obolibrary.org/obo/GO_0009134) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "nucleoside diphosphate breakdown" + +- [nucleoside diphosphate catabolic process](http://purl.obolibrary.org/obo/GO_0009134) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" + +- [nucleoside diphosphate catabolic process](http://purl.obolibrary.org/obo/GO_0009134) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The chemical reactions and pathways resulting in the breakdown of a nucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with diphosphate on the sugar." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:go_curators" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ISBN:0198506732" + +- Class: [nucleoside diphosphate catabolic process](http://purl.obolibrary.org/obo/GO_0009134) + +- [nucleoside diphosphate catabolic process](http://purl.obolibrary.org/obo/GO_0009134) EquivalentTo [catabolic process](http://purl.obolibrary.org/obo/GO_0009056) and ([has primary input](http://purl.obolibrary.org/obo/RO_0004009) some [CHEBI_57930](http://purl.obolibrary.org/obo/CHEBI_57930)) + +- [nucleoside diphosphate catabolic process](http://purl.obolibrary.org/obo/GO_0009134) SubClassOf [nucleoside diphosphate metabolic process](http://purl.obolibrary.org/obo/GO_0009132) + +- [nucleoside diphosphate catabolic process](http://purl.obolibrary.org/obo/GO_0009134) SubClassOf [catabolic process](http://purl.obolibrary.org/obo/GO_0009056) + +- [nucleoside diphosphate catabolic process](http://purl.obolibrary.org/obo/GO_0009134) SubClassOf [has primary input](http://purl.obolibrary.org/obo/RO_0004009) some [CHEBI_57930](http://purl.obolibrary.org/obo/CHEBI_57930) + + + +### nucleoside diphosphate metabolic process `http://purl.obolibrary.org/obo/GO_0009132` +#### Removed +- [nucleoside diphosphate metabolic process](http://purl.obolibrary.org/obo/GO_0009132) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0009132" + +- [nucleoside diphosphate metabolic process](http://purl.obolibrary.org/obo/GO_0009132) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "nucleoside diphosphate metabolism" + +- [nucleoside diphosphate metabolic process](http://purl.obolibrary.org/obo/GO_0009132) [label](http://www.w3.org/2000/01/rdf-schema#label) "nucleoside diphosphate metabolic process" + +- [nucleoside diphosphate metabolic process](http://purl.obolibrary.org/obo/GO_0009132) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" + +- [nucleoside diphosphate metabolic process](http://purl.obolibrary.org/obo/GO_0009132) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The chemical reactions and pathways involving a nucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with diphosphate on the sugar." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:go_curators" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ISBN:0198506732" + +- Class: [nucleoside diphosphate metabolic process](http://purl.obolibrary.org/obo/GO_0009132) + +- [nucleoside diphosphate metabolic process](http://purl.obolibrary.org/obo/GO_0009132) EquivalentTo [metabolic process](http://purl.obolibrary.org/obo/GO_0008152) and ([has primary input or output](http://purl.obolibrary.org/obo/RO_0004007) some [CHEBI_57930](http://purl.obolibrary.org/obo/CHEBI_57930)) + +- [nucleoside diphosphate metabolic process](http://purl.obolibrary.org/obo/GO_0009132) SubClassOf [metabolic process](http://purl.obolibrary.org/obo/GO_0008152) + +- [nucleoside diphosphate metabolic process](http://purl.obolibrary.org/obo/GO_0009132) SubClassOf [has primary input or output](http://purl.obolibrary.org/obo/RO_0004007) some [CHEBI_57930](http://purl.obolibrary.org/obo/CHEBI_57930) + + + +### nucleoside triphosphate biosynthetic process `http://purl.obolibrary.org/obo/GO_0009142` +#### Removed +- [nucleoside triphosphate biosynthetic process](http://purl.obolibrary.org/obo/GO_0009142) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The chemical reactions and pathways resulting in the formation of a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:go_curators" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ISBN:0198506732" + +- [nucleoside triphosphate biosynthetic process](http://purl.obolibrary.org/obo/GO_0009142) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" + +- [nucleoside triphosphate biosynthetic process](http://purl.obolibrary.org/obo/GO_0009142) [label](http://www.w3.org/2000/01/rdf-schema#label) "nucleoside triphosphate biosynthetic process" + +- [nucleoside triphosphate biosynthetic process](http://purl.obolibrary.org/obo/GO_0009142) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "nucleoside triphosphate formation" + +- [nucleoside triphosphate biosynthetic process](http://purl.obolibrary.org/obo/GO_0009142) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "nucleoside triphosphate anabolism" + +- [nucleoside triphosphate biosynthetic process](http://purl.obolibrary.org/obo/GO_0009142) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "nucleoside triphosphate biosynthesis" + +- [nucleoside triphosphate biosynthetic process](http://purl.obolibrary.org/obo/GO_0009142) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "nucleoside triphosphate synthesis" + +- [nucleoside triphosphate biosynthetic process](http://purl.obolibrary.org/obo/GO_0009142) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0009142" + +- Class: [nucleoside triphosphate biosynthetic process](http://purl.obolibrary.org/obo/GO_0009142) + +- [nucleoside triphosphate biosynthetic process](http://purl.obolibrary.org/obo/GO_0009142) EquivalentTo [biosynthetic process](http://purl.obolibrary.org/obo/GO_0009058) and ([has primary output](http://purl.obolibrary.org/obo/RO_0004008) some [CHEBI_61557](http://purl.obolibrary.org/obo/CHEBI_61557)) + +- [nucleoside triphosphate biosynthetic process](http://purl.obolibrary.org/obo/GO_0009142) SubClassOf [nucleoside triphosphate metabolic process](http://purl.obolibrary.org/obo/GO_0009141) + +- [nucleoside triphosphate biosynthetic process](http://purl.obolibrary.org/obo/GO_0009142) SubClassOf [has primary output](http://purl.obolibrary.org/obo/RO_0004008) some [CHEBI_61557](http://purl.obolibrary.org/obo/CHEBI_61557) + +- [nucleoside triphosphate biosynthetic process](http://purl.obolibrary.org/obo/GO_0009142) SubClassOf [biosynthetic process](http://purl.obolibrary.org/obo/GO_0009058) + + + +### nucleoside triphosphate catabolic process `http://purl.obolibrary.org/obo/GO_0009143` +#### Removed +- [nucleoside triphosphate catabolic process](http://purl.obolibrary.org/obo/GO_0009143) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "nucleoside triphosphate degradation" + +- [nucleoside triphosphate catabolic process](http://purl.obolibrary.org/obo/GO_0009143) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The chemical reactions and pathways resulting in the breakdown of a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:go_curators" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ISBN:0198506732" + +- [nucleoside triphosphate catabolic process](http://purl.obolibrary.org/obo/GO_0009143) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" + +- [nucleoside triphosphate catabolic process](http://purl.obolibrary.org/obo/GO_0009143) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0009143" + +- [nucleoside triphosphate catabolic process](http://purl.obolibrary.org/obo/GO_0009143) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "nucleoside triphosphate breakdown" + +- [nucleoside triphosphate catabolic process](http://purl.obolibrary.org/obo/GO_0009143) [label](http://www.w3.org/2000/01/rdf-schema#label) "nucleoside triphosphate catabolic process" + +- [nucleoside triphosphate catabolic process](http://purl.obolibrary.org/obo/GO_0009143) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "nucleoside triphosphate catabolism" + +- Class: [nucleoside triphosphate catabolic process](http://purl.obolibrary.org/obo/GO_0009143) + +- [nucleoside triphosphate catabolic process](http://purl.obolibrary.org/obo/GO_0009143) EquivalentTo [catabolic process](http://purl.obolibrary.org/obo/GO_0009056) and ([has primary input](http://purl.obolibrary.org/obo/RO_0004009) some [CHEBI_61557](http://purl.obolibrary.org/obo/CHEBI_61557)) + +- [nucleoside triphosphate catabolic process](http://purl.obolibrary.org/obo/GO_0009143) SubClassOf [has primary input](http://purl.obolibrary.org/obo/RO_0004009) some [CHEBI_61557](http://purl.obolibrary.org/obo/CHEBI_61557) + +- [nucleoside triphosphate catabolic process](http://purl.obolibrary.org/obo/GO_0009143) SubClassOf [catabolic process](http://purl.obolibrary.org/obo/GO_0009056) + +- [nucleoside triphosphate catabolic process](http://purl.obolibrary.org/obo/GO_0009143) SubClassOf [nucleoside triphosphate metabolic process](http://purl.obolibrary.org/obo/GO_0009141) + + + +### nucleoside triphosphate metabolic process `http://purl.obolibrary.org/obo/GO_0009141` +#### Removed +- [nucleoside triphosphate metabolic process](http://purl.obolibrary.org/obo/GO_0009141) [label](http://www.w3.org/2000/01/rdf-schema#label) "nucleoside triphosphate metabolic process" + +- [nucleoside triphosphate metabolic process](http://purl.obolibrary.org/obo/GO_0009141) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0009141" + +- [nucleoside triphosphate metabolic process](http://purl.obolibrary.org/obo/GO_0009141) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" + +- [nucleoside triphosphate metabolic process](http://purl.obolibrary.org/obo/GO_0009141) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "nucleoside triphosphate metabolism" + +- [nucleoside triphosphate metabolic process](http://purl.obolibrary.org/obo/GO_0009141) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The chemical reactions and pathways involving a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:go_curators" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ISBN:0198506732" + +- Class: [nucleoside triphosphate metabolic process](http://purl.obolibrary.org/obo/GO_0009141) + +- [nucleoside triphosphate metabolic process](http://purl.obolibrary.org/obo/GO_0009141) EquivalentTo [metabolic process](http://purl.obolibrary.org/obo/GO_0008152) and ([has primary input or output](http://purl.obolibrary.org/obo/RO_0004007) some [CHEBI_61557](http://purl.obolibrary.org/obo/CHEBI_61557)) + +- [nucleoside triphosphate metabolic process](http://purl.obolibrary.org/obo/GO_0009141) SubClassOf [metabolic process](http://purl.obolibrary.org/obo/GO_0008152) + +- [nucleoside triphosphate metabolic process](http://purl.obolibrary.org/obo/GO_0009141) SubClassOf [has primary input or output](http://purl.obolibrary.org/obo/RO_0004007) some [CHEBI_61557](http://purl.obolibrary.org/obo/CHEBI_61557) + + + +### nucleus `http://purl.obolibrary.org/obo/GO_0005634` + +#### Added +- [nucleus](http://purl.obolibrary.org/obo/GO_0005634) DisjointWith [cytosol](http://purl.obolibrary.org/obo/GO_0005829) + +- [nucleus](http://purl.obolibrary.org/obo/GO_0005634) DisjointWith [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [cytosol](http://purl.obolibrary.org/obo/GO_0005829) + + +### obsolescence reason specification `http://purl.obolibrary.org/obo/IAO_0000225` +#### Removed +- [obsolescence reason specification](http://purl.obolibrary.org/obo/IAO_0000225) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The reason for which a term has been deprecated. The allowed values come from an enumerated list of predefined terms. See the specification of these instances for more detailed definitions of each enumerated value."@en + +- [obsolescence reason specification](http://purl.obolibrary.org/obo/IAO_0000225) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "obsolescence reason specification"@en + +- [obsolescence reason specification](http://purl.obolibrary.org/obo/IAO_0000225) [label](http://www.w3.org/2000/01/rdf-schema#label) "obsolescence reason specification"@en + +- [obsolescence reason specification](http://purl.obolibrary.org/obo/IAO_0000225) [editor note](http://purl.obolibrary.org/obo/IAO_0000116) "The creation of this class has been inspired in part by Werner Ceusters' paper, Applying evolutionary terminology auditing to the Gene Ontology."@en + +- [obsolescence reason specification](http://purl.obolibrary.org/obo/IAO_0000225) [IAO_0000114](http://purl.obolibrary.org/obo/IAO_0000114) [pending final vetting](http://purl.obolibrary.org/obo/IAO_0000125) + +- [obsolescence reason specification](http://purl.obolibrary.org/obo/IAO_0000225) [IAO_0000117](http://purl.obolibrary.org/obo/IAO_0000117) "PERSON: Alan Ruttenberg"@en + +- [obsolescence reason specification](http://purl.obolibrary.org/obo/IAO_0000225) [IAO_0000117](http://purl.obolibrary.org/obo/IAO_0000117) "PERSON: Melanie Courtot"@en + +- Class: [obsolescence reason specification](http://purl.obolibrary.org/obo/IAO_0000225) + +- [obsolescence reason specification](http://purl.obolibrary.org/obo/IAO_0000225) EquivalentTo {[failed exploratory term](http://purl.obolibrary.org/obo/IAO_0000103) , [placeholder removed](http://purl.obolibrary.org/obo/IAO_0000226) , [terms merged](http://purl.obolibrary.org/obo/IAO_0000227) , [term imported](http://purl.obolibrary.org/obo/IAO_0000228) , [term split](http://purl.obolibrary.org/obo/IAO_0000229) , [OMO_0001000](http://purl.obolibrary.org/obo/OMO_0001000)} + +- [obsolescence reason specification](http://purl.obolibrary.org/obo/IAO_0000225) SubClassOf [data about an ontology part](http://purl.obolibrary.org/obo/IAO_0000102) + + + +### odontoclast `http://purl.obolibrary.org/obo/CL_0000588` +#### Removed +- [odontoclast](http://purl.obolibrary.org/obo/CL_0000588) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A specialized osteoclast associated with the absorption and removal of cementum." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "MESH:A11.329.679" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:add" + +#### Added +- [odontoclast](http://purl.obolibrary.org/obo/CL_0000588) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A specialized osteoclast associated with the absorption and removal of cementum." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:add" + + +### olfactory bulb granule cell layer `http://purl.obolibrary.org/obo/UBERON_0005378` + +#### Added +- [olfactory bulb granule cell layer](http://purl.obolibrary.org/obo/UBERON_0005378) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "NLXANAT:20090404" + +- [olfactory bulb granule cell layer](http://purl.obolibrary.org/obo/UBERON_0005378) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "granule cell layer" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "BTO:0001327" + +- [olfactory bulb granule cell layer](http://purl.obolibrary.org/obo/UBERON_0005378) [id](http://www.geneontology.org/formats/oboInOwl#id) "UBERON:0005378" + +- [olfactory bulb granule cell layer](http://purl.obolibrary.org/obo/UBERON_0005378) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "accessory olfactory bulb granule cell layer" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "BAMS:gr" + +- [olfactory bulb granule cell layer](http://purl.obolibrary.org/obo/UBERON_0005378) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "main olfactory bulb, granule layer" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "BAMS:MOBgr" + +- [olfactory bulb granule cell layer](http://purl.obolibrary.org/obo/UBERON_0005378) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "uberon" + +- [olfactory bulb granule cell layer](http://purl.obolibrary.org/obo/UBERON_0005378) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "main olfactory bulb granule cell layer" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "BAMS:MOBgr" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "BAMS:gr" + +- [olfactory bulb granule cell layer](http://purl.obolibrary.org/obo/UBERON_0005378) [label](http://www.w3.org/2000/01/rdf-schema#label) "olfactory bulb granule cell layer" + +- [olfactory bulb granule cell layer](http://purl.obolibrary.org/obo/UBERON_0005378) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "MBA:220" + +- [olfactory bulb granule cell layer](http://purl.obolibrary.org/obo/UBERON_0005378) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "BAMS:MOBgr" + +- [olfactory bulb granule cell layer](http://purl.obolibrary.org/obo/UBERON_0005378) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "EMAPA:35609" + +- [olfactory bulb granule cell layer](http://purl.obolibrary.org/obo/UBERON_0005378) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "DMBA:15909" + +- [olfactory bulb granule cell layer](http://purl.obolibrary.org/obo/UBERON_0005378) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The granule cell layer contains multiple small round neurons that lack axons. Long dendritic processes of the neurons reach the more superficial layers and inhibit mitral cells and tufted cells. Small distal processes make contacts with the exiting mitral cell axons." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "BTO:0001327" + +- [olfactory bulb granule cell layer](http://purl.obolibrary.org/obo/UBERON_0005378) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "olfactory bulb main granule cell layer" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "NLXANAT:20090404" + +- [olfactory bulb granule cell layer](http://purl.obolibrary.org/obo/UBERON_0005378) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "BTO:0001327" + +- [olfactory bulb granule cell layer](http://purl.obolibrary.org/obo/UBERON_0005378) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "neuronames:2714" + +- [olfactory bulb granule cell layer](http://purl.obolibrary.org/obo/UBERON_0005378) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [pheno_slim](http://purl.obolibrary.org/obo/uberon/core#pheno_slim) + +- [olfactory bulb granule cell layer](http://purl.obolibrary.org/obo/UBERON_0005378) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "granule layer of main olfactory bulb" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "NLXANAT:20090404" + +- [olfactory bulb granule cell layer](http://purl.obolibrary.org/obo/UBERON_0005378) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "MA:0000971" + +- Class: [olfactory bulb granule cell layer](http://purl.obolibrary.org/obo/UBERON_0005378) + +- [olfactory bulb granule cell layer](http://purl.obolibrary.org/obo/UBERON_0005378) SubClassOf [olfactory bulb layer](http://purl.obolibrary.org/obo/UBERON_0004001) + + +### olfactory granule cell `http://purl.obolibrary.org/obo/CL_0000626` +#### Removed +- [olfactory granule cell](http://purl.obolibrary.org/obo/CL_0000626) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Granule cell that is part of the olfactory bulb." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:mah" + +- [olfactory granule cell](http://purl.obolibrary.org/obo/CL_0000626) EquivalentTo [granule cell](http://purl.obolibrary.org/obo/CL_0000120) and ([has soma location](http://purl.obolibrary.org/obo/RO_0002100) some [olfactory bulb](http://purl.obolibrary.org/obo/UBERON_0002264)) + +- [olfactory granule cell](http://purl.obolibrary.org/obo/CL_0000626) SubClassOf [has soma location](http://purl.obolibrary.org/obo/RO_0002100) some [olfactory bulb](http://purl.obolibrary.org/obo/UBERON_0002264) + +#### Added +- [olfactory granule cell](http://purl.obolibrary.org/obo/CL_0000626) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A granule cell that has a soma located in an olfactory bulb granule cell layer. An olfactory granule cell is an interneuron that lacks an axon, makes reciprocal dendro-dendritic synapses with mitral cells and tufted cells and is involved in the fine spatio-temporal tuning of the responses of these principal olfactory bulb neurons to odors." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:mah" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1038/s41598-018-27692-8" + +- [olfactory granule cell](http://purl.obolibrary.org/obo/CL_0000626) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "olfactory bulb granule cell" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1038/s41598-018-27692-8" + +- [olfactory granule cell](http://purl.obolibrary.org/obo/CL_0000626) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "Granule cells are the most abundant neuronal population in the olfactory bulb and are continuously renewed throughout life." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1038/s41598-018-27692-8" + +- [olfactory granule cell](http://purl.obolibrary.org/obo/CL_0000626) EquivalentTo [granule cell](http://purl.obolibrary.org/obo/CL_0000120) and ([has soma location](http://purl.obolibrary.org/obo/RO_0002100) some [olfactory bulb granule cell layer](http://purl.obolibrary.org/obo/UBERON_0005378)) + +- [olfactory granule cell](http://purl.obolibrary.org/obo/CL_0000626) SubClassOf [has soma location](http://purl.obolibrary.org/obo/RO_0002100) some [olfactory bulb granule cell layer](http://purl.obolibrary.org/obo/UBERON_0005378) + +- [olfactory granule cell](http://purl.obolibrary.org/obo/CL_0000626) SubClassOf [synapsed by](http://purl.obolibrary.org/obo/RO_0002103) some [mitral cell](http://purl.obolibrary.org/obo/CL_1001502) + +- [olfactory granule cell](http://purl.obolibrary.org/obo/CL_0000626) SubClassOf [synapsed to](http://purl.obolibrary.org/obo/RO_0002120) some [olfactory bulb tufted cell](http://purl.obolibrary.org/obo/CL_1001503) + +- [olfactory granule cell](http://purl.obolibrary.org/obo/CL_0000626) SubClassOf [synapsed by](http://purl.obolibrary.org/obo/RO_0002103) some [olfactory bulb tufted cell](http://purl.obolibrary.org/obo/CL_1001503) + +- [olfactory granule cell](http://purl.obolibrary.org/obo/CL_0000626) SubClassOf [olfactory bulb interneuron](http://purl.obolibrary.org/obo/CL_1001434) + +- [olfactory granule cell](http://purl.obolibrary.org/obo/CL_0000626) SubClassOf [involved in regulation of](http://purl.obolibrary.org/obo/RO_0002428) some [sensory perception of smell](http://purl.obolibrary.org/obo/GO_0007608) + +- [olfactory granule cell](http://purl.obolibrary.org/obo/CL_0000626) SubClassOf [synapsed to](http://purl.obolibrary.org/obo/RO_0002120) some [mitral cell](http://purl.obolibrary.org/obo/CL_1001502) + + +### oligodendrocyte precursor cell `http://purl.obolibrary.org/obo/CL_0002453` +#### Removed +- [oligodendrocyte precursor cell](http://purl.obolibrary.org/obo/CL_0002453) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "O-2A/OPC" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:24133281" + +- [oligodendrocyte precursor cell](http://purl.obolibrary.org/obo/CL_0002453) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "O2A/OPC" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:11756508" + +#### Added +- [oligodendrocyte precursor cell](http://purl.obolibrary.org/obo/CL_0002453) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "O2A/OPC" + - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation) + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:11756508" + +- [oligodendrocyte precursor cell](http://purl.obolibrary.org/obo/CL_0002453) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "O-2A/OPC" + - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation) + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:24133281" + + +### oocyte morphogenesis `http://purl.obolibrary.org/obo/GO_0048601` +#### Removed +- [oocyte morphogenesis](http://purl.obolibrary.org/obo/GO_0048601) SubClassOf [cell morphogenesis involved in differentiation](http://purl.obolibrary.org/obo/GO_0000904) + +#### Added +- [oocyte morphogenesis](http://purl.obolibrary.org/obo/GO_0048601) SubClassOf [cell morphogenesis](http://purl.obolibrary.org/obo/GO_0000902) + + +### organizational term `http://purl.obolibrary.org/obo/IAO_0000121` +#### Removed +- [organizational term](http://purl.obolibrary.org/obo/IAO_0000121) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Term created to ease viewing/sort terms for development purpose, and will not be included in a release"@en + +- [organizational term](http://purl.obolibrary.org/obo/IAO_0000121) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "organizational term"@en + +- [organizational term](http://purl.obolibrary.org/obo/IAO_0000121) [label](http://www.w3.org/2000/01/rdf-schema#label) "organizational term"@en + +- Individual: [organizational term](http://purl.obolibrary.org/obo/IAO_0000121) + + + +### ovarian nurse cell to oocyte transport `http://purl.obolibrary.org/obo/GO_0007300` + +#### Added +- [ovarian nurse cell to oocyte transport](http://purl.obolibrary.org/obo/GO_0007300) [label](http://www.w3.org/2000/01/rdf-schema#label) "ovarian nurse cell to oocyte transport" + +- [ovarian nurse cell to oocyte transport](http://purl.obolibrary.org/obo/GO_0007300) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Transfer of constituents synthesized in the ovarian nurse cells to the oocyte, through the ring canals, as the egg chamber is growing. An example of this is found in Drosophila melanogaster." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:mtg_sensu" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ISBN:0879694238" + +- [ovarian nurse cell to oocyte transport](http://purl.obolibrary.org/obo/GO_0007300) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "nurse cell to oocyte transport" + +- [ovarian nurse cell to oocyte transport](http://purl.obolibrary.org/obo/GO_0007300) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" + +- [ovarian nurse cell to oocyte transport](http://purl.obolibrary.org/obo/GO_0007300) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0007300" + +- Class: [ovarian nurse cell to oocyte transport](http://purl.obolibrary.org/obo/GO_0007300) + +- [ovarian nurse cell to oocyte transport](http://purl.obolibrary.org/obo/GO_0007300) EquivalentTo [transport](http://purl.obolibrary.org/obo/GO_0006810) and ([has target start location](http://purl.obolibrary.org/obo/RO_0002338) some [invertebrate nurse cell](http://purl.obolibrary.org/obo/CL_0000026)) and ([has target end location](http://purl.obolibrary.org/obo/RO_0002339) some [oocyte](http://purl.obolibrary.org/obo/CL_0000023)) and ([results in transport along](http://purl.obolibrary.org/obo/RO_0002341) some [germline ring canal](http://purl.obolibrary.org/obo/GO_0045172)) + +- [ovarian nurse cell to oocyte transport](http://purl.obolibrary.org/obo/GO_0007300) SubClassOf [reproductive process](http://purl.obolibrary.org/obo/GO_0022414) + +- [ovarian nurse cell to oocyte transport](http://purl.obolibrary.org/obo/GO_0007300) SubClassOf [transport](http://purl.obolibrary.org/obo/GO_0006810) + +- [ovarian nurse cell to oocyte transport](http://purl.obolibrary.org/obo/GO_0007300) SubClassOf [results in transport along](http://purl.obolibrary.org/obo/RO_0002341) some [germline ring canal](http://purl.obolibrary.org/obo/GO_0045172) + +- [ovarian nurse cell to oocyte transport](http://purl.obolibrary.org/obo/GO_0007300) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [oogenesis](http://purl.obolibrary.org/obo/GO_0048477) + +- [ovarian nurse cell to oocyte transport](http://purl.obolibrary.org/obo/GO_0007300) SubClassOf [has target end location](http://purl.obolibrary.org/obo/RO_0002339) some [oocyte](http://purl.obolibrary.org/obo/CL_0000023) + +- [ovarian nurse cell to oocyte transport](http://purl.obolibrary.org/obo/GO_0007300) SubClassOf [has target start location](http://purl.obolibrary.org/obo/RO_0002338) some [invertebrate nurse cell](http://purl.obolibrary.org/obo/CL_0000026) + +- [ovarian nurse cell to oocyte transport](http://purl.obolibrary.org/obo/GO_0007300) SubClassOf [in taxon](http://purl.obolibrary.org/obo/RO_0002162) only [Insecta](http://purl.obolibrary.org/obo/NCBITaxon_50557) + +- [ovarian nurse cell to oocyte transport](http://purl.obolibrary.org/obo/GO_0007300) SubClassOf [only in taxon](http://purl.obolibrary.org/obo/RO_0002160) some [Insecta](http://purl.obolibrary.org/obo/NCBITaxon_50557) + + +### oxytocin receptor sst GABAergic cortical interneuron `http://purl.obolibrary.org/obo/CL_4023122` +#### Removed +- [oxytocin receptor sst GABAergic cortical interneuron](http://purl.obolibrary.org/obo/CL_4023122) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "OxtrINs" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:25303526" + +#### Added +- [oxytocin receptor sst GABAergic cortical interneuron](http://purl.obolibrary.org/obo/CL_4023122) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "OxtrINs" + - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation) + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:25303526" + + +### pain receptor cell `http://purl.obolibrary.org/obo/CL_0000198` +#### Removed +- [pain receptor cell](http://purl.obolibrary.org/obo/CL_0000198) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "nociceptor" + +- [pain receptor cell](http://purl.obolibrary.org/obo/CL_0000198) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "nocireceptor" + +#### Added +- [pain receptor cell](http://purl.obolibrary.org/obo/CL_0000198) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "nocireceptor" + - [see also](http://www.w3.org/2000/01/rdf-schema#seeAlso) "https://www.thefreedictionary.com/nocireceptor"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI) + +- [pain receptor cell](http://purl.obolibrary.org/obo/CL_0000198) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "nociceptor" + - [see also](http://www.w3.org/2000/01/rdf-schema#seeAlso) "https://meshb.nlm.nih.gov/record/ui?ui=D009619"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI) + + +### parietal cell `http://purl.obolibrary.org/obo/CL_0000162` +#### Removed +- [parietal cell](http://purl.obolibrary.org/obo/CL_0000162) SubClassOf [acid secreting cell](http://purl.obolibrary.org/obo/CL_0000161) + +#### Added +- [parietal cell](http://purl.obolibrary.org/obo/CL_0000162) SubClassOf [capable of](http://purl.obolibrary.org/obo/RO_0002215) some [acid secretion](http://purl.obolibrary.org/obo/GO_0046717) + + +### pending final vetting `http://purl.obolibrary.org/obo/IAO_0000125` +#### Removed +- [pending final vetting](http://purl.obolibrary.org/obo/IAO_0000125) [label](http://www.w3.org/2000/01/rdf-schema#label) "pending final vetting"@en + +- [pending final vetting](http://purl.obolibrary.org/obo/IAO_0000125) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "pending final vetting"@en + +- [pending final vetting](http://purl.obolibrary.org/obo/IAO_0000125) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "All definitions, placement in the asserted IS_A hierarchy and required minimal metadata are complete. The class is awaiting a final review by someone other than the term editor."@en + +- Individual: [pending final vetting](http://purl.obolibrary.org/obo/IAO_0000125) + + + +### perivascular cell `http://purl.obolibrary.org/obo/CL_4033054` + +#### Added +- [perivascular cell](http://purl.obolibrary.org/obo/CL_4033054) [contributor](http://purl.org/dc/terms/contributor) [0000-0001-6677-8489](https://orcid.org/0000-0001-6677-8489) + +- [perivascular cell](http://purl.obolibrary.org/obo/CL_4033054) [label](http://www.w3.org/2000/01/rdf-schema#label) "perivascular cell" + +- [perivascular cell](http://purl.obolibrary.org/obo/CL_4033054) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A cell that is adjacent to a vessel. A perivascular cell plays a crucial role in maintaining vascular function and tissue homeostasis. This cell type regulates vessel integrity and flow dynamics." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:27889329" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:24928499" + +- [perivascular cell](http://purl.obolibrary.org/obo/CL_4033054) [date](http://purl.org/dc/terms/date) "2023-08-22T13:40:28Z"^^[dateTime](http://www.w3.org/2001/XMLSchema#dateTime) + +- Class: [perivascular cell](http://purl.obolibrary.org/obo/CL_4033054) + +- [perivascular cell](http://purl.obolibrary.org/obo/CL_4033054) EquivalentTo [native cell](http://purl.obolibrary.org/obo/CL_0000003) and ([adjacent to](http://purl.obolibrary.org/obo/RO_0002220) some [vasculature](http://purl.obolibrary.org/obo/UBERON_0002049)) + +- [perivascular cell](http://purl.obolibrary.org/obo/CL_4033054) SubClassOf [native cell](http://purl.obolibrary.org/obo/CL_0000003) + +- [perivascular cell](http://purl.obolibrary.org/obo/CL_4033054) SubClassOf [adjacent to](http://purl.obolibrary.org/obo/RO_0002220) some [vasculature](http://purl.obolibrary.org/obo/UBERON_0002049) + + +### perivascular macrophage `http://purl.obolibrary.org/obo/CL_0000881` + +#### Added +- [perivascular macrophage](http://purl.obolibrary.org/obo/CL_0000881) SubClassOf [perivascular cell](http://purl.obolibrary.org/obo/CL_4033054) + + +### photoreceptor cell `http://purl.obolibrary.org/obo/CL_0000210` + +#### Added +- [photoreceptor cell](http://purl.obolibrary.org/obo/CL_0000210) [depicted by](http://xmlns.com/foaf/0.1/depicted_by) "https://www.swissbiopics.org/api/image/Photoreceptor_cell.svg"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI) + + +### placeholder removed `http://purl.obolibrary.org/obo/IAO_0000226` +#### Removed +- [placeholder removed](http://purl.obolibrary.org/obo/IAO_0000226) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "placeholder removed"@en + +- [placeholder removed](http://purl.obolibrary.org/obo/IAO_0000226) [label](http://www.w3.org/2000/01/rdf-schema#label) "placeholder removed"@en + +- Individual: [placeholder removed](http://purl.obolibrary.org/obo/IAO_0000226) + + + +### platelet morphogenesis `http://purl.obolibrary.org/obo/GO_0036344` +#### Removed +- [platelet morphogenesis](http://purl.obolibrary.org/obo/GO_0036344) SubClassOf [cell morphogenesis involved in differentiation](http://purl.obolibrary.org/obo/GO_0000904) + +#### Added +- [platelet morphogenesis](http://purl.obolibrary.org/obo/GO_0036344) SubClassOf [cell morphogenesis](http://purl.obolibrary.org/obo/GO_0000902) + + +### positive regulation of ATP-dependent activity `http://purl.obolibrary.org/obo/GO_0032781` +#### Removed +- [positive regulation of ATP-dependent activity](http://purl.obolibrary.org/obo/GO_0032781) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0032781" + +- [positive regulation of ATP-dependent activity](http://purl.obolibrary.org/obo/GO_0032781) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that activates or increases the rate of an ATP-dependent activity." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:mah" + +- [positive regulation of ATP-dependent activity](http://purl.obolibrary.org/obo/GO_0032781) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "positive regulation of ATPase activity" + +- [positive regulation of ATP-dependent activity](http://purl.obolibrary.org/obo/GO_0032781) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "upregulation of ATPase activity" + +- [positive regulation of ATP-dependent activity](http://purl.obolibrary.org/obo/GO_0032781) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "activation of ATPase activity" + +- [positive regulation of ATP-dependent activity](http://purl.obolibrary.org/obo/GO_0032781) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "positive regulation of adenosinetriphosphatase activity" + +- [positive regulation of ATP-dependent activity](http://purl.obolibrary.org/obo/GO_0032781) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "stimulation of ATPase activity" + +- [positive regulation of ATP-dependent activity](http://purl.obolibrary.org/obo/GO_0032781) [term tracker item](http://purl.obolibrary.org/obo/IAO_0000233) "https://github.com/geneontology/go-ontology/issues/22371"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI) + +- [positive regulation of ATP-dependent activity](http://purl.obolibrary.org/obo/GO_0032781) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "up-regulation of ATPase activity" + +- [positive regulation of ATP-dependent activity](http://purl.obolibrary.org/obo/GO_0032781) [label](http://www.w3.org/2000/01/rdf-schema#label) "positive regulation of ATP-dependent activity" + +- [positive regulation of ATP-dependent activity](http://purl.obolibrary.org/obo/GO_0032781) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate) + +- [positive regulation of ATP-dependent activity](http://purl.obolibrary.org/obo/GO_0032781) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "up regulation of ATPase activity" + +- [positive regulation of ATP-dependent activity](http://purl.obolibrary.org/obo/GO_0032781) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" + +- Class: [positive regulation of ATP-dependent activity](http://purl.obolibrary.org/obo/GO_0032781) + +- [positive regulation of ATP-dependent activity](http://purl.obolibrary.org/obo/GO_0032781) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([positively regulates](http://purl.obolibrary.org/obo/RO_0002213) some [ATP-dependent activity](http://purl.obolibrary.org/obo/GO_0140657)) + +- [positive regulation of ATP-dependent activity](http://purl.obolibrary.org/obo/GO_0032781) SubClassOf [regulation of ATP-dependent activity](http://purl.obolibrary.org/obo/GO_0043462) + +- [positive regulation of ATP-dependent activity](http://purl.obolibrary.org/obo/GO_0032781) SubClassOf [positive regulation of molecular function](http://purl.obolibrary.org/obo/GO_0044093) + +- [positive regulation of ATP-dependent activity](http://purl.obolibrary.org/obo/GO_0032781) SubClassOf [positively regulates](http://purl.obolibrary.org/obo/RO_0002213) some [ATP-dependent activity](http://purl.obolibrary.org/obo/GO_0140657) + + + +### positive regulation of Atg1/ULK1 kinase complex assembly `http://purl.obolibrary.org/obo/GO_1905866` +#### Removed +- [positive regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905866) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "up-regulation of Atg1p signalling complex assembly" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905866) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "activation of ATG1-ATG13 complex formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905866) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "positive regulation of ATG1-ATG13 complex formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905866) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "up-regulation of ATG1 kinase complex formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905866) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "up regulation of ATG1 kinase complex assembly" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905866) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "up-regulation of ULK1-ATG13-RB1CC1 complex formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905866) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "up regulation of ATG1/ULK1 kinase complex assembly" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905866) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "activation of ATG1 kinase complex formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905866) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "positive regulation of ULK1 signaling complex assembly" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905866) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2017-01-26T13:23:44Z" + +- [positive regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905866) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "upregulation of ATG1/ULK1 kinase complex formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905866) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "upregulation of ATG1/ULK1 signaling complex formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905866) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "up regulation of ULK1 signaling complex formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905866) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "up regulation of ULK1 signaling complex assembly" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905866) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "positive regulation of ATG1/ULK1 signaling complex assembly" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905866) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "up regulation of ATG1-ATG13 complex assembly" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905866) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "activation of ATG1/ULK1 signaling complex formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905866) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" + +- [positive regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905866) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "activation of ATG1/ULK1 signaling complex assembly" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905866) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "upregulation of ATG1 kinase complex formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905866) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "up-regulation of ULK1 signaling complex assembly" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905866) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "activation of ULK1 signaling complex formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905866) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "up regulation of Atg1p signalling complex assembly" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905866) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "up-regulation of ATG1/ULK1 signaling complex assembly" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905866) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "pr" + +- [positive regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905866) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "upregulation of Atg1p signalling complex formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905866) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "up-regulation of ATG1 kinase complex assembly" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905866) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "activation of Atg1p signalling complex formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905866) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "upregulation of ULK1-ATG13-FIP200 complex formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905866) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "activation of ULK1-ATG13-RB1CC1 complex formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905866) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "up regulation of ULK1-ATG13-FIP200 complex assembly" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905866) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "positive regulation of ATG1-ATG13 complex assembly" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905866) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "positive regulation of ULK1-ATG13-RB1CC1 complex assembly" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905866) [label](http://www.w3.org/2000/01/rdf-schema#label) "positive regulation of Atg1/ULK1 kinase complex assembly" + +- [positive regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905866) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "up-regulation of ATG1/ULK1 kinase complex formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905866) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "activation of ATG1/ULK1 kinase complex assembly" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905866) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "activation of ATG1 kinase complex assembly" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905866) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "activation of ULK1 signaling complex assembly" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905866) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "activation of ATG1/ULK1 kinase complex formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905866) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "up-regulation of Atg1p signalling complex formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905866) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "upregulation of ULK1-ATG13-RB1CC1 complex formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905866) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "up regulation of ATG1/ULK1 signaling complex assembly" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905866) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "up-regulation of ULK1-ATG13-FIP200 complex formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905866) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "positive regulation of ATG1/ULK1 kinase complex formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905866) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "up-regulation of ATG1-ATG13 complex formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905866) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "upregulation of ATG1/ULK1 signaling complex assembly" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905866) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "upregulation of ATG1-ATG13 complex formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905866) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "positive regulation of Atg1p signalling complex assembly" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905866) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "up regulation of ULK1-ATG13-RB1CC1 complex assembly" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905866) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "upregulation of ULK1-ATG13-FIP200 complex assembly" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905866) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "positive regulation of ULK1 signaling complex formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905866) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "up regulation of ATG1-ATG13 complex formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905866) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "upregulation of Atg1p signalling complex assembly" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905866) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "up regulation of ATG1 kinase complex formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905866) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "activation of ULK1-ATG13-RB1CC1 complex assembly" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905866) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "up regulation of ULK1-ATG13-RB1CC1 complex formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905866) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "activation of ULK1-ATG13-FIP200 complex assembly" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905866) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "positive regulation of ULK1-ATG13-RB1CC1 complex formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905866) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "up regulation of Atg1p signalling complex formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905866) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "positive regulation of ATG1/ULK1 signaling complex formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905866) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "activation of Atg1p signalling complex assembly" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905866) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "upregulation of ATG1 kinase complex assembly" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905866) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "up-regulation of ULK1-ATG13-FIP200 complex assembly" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905866) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "upregulation of ULK1 signaling complex formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905866) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "up-regulation of ATG1-ATG13 complex assembly" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905866) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "positive regulation of ULK1-ATG13-FIP200 complex formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905866) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "up-regulation of ULK1 signaling complex formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905866) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "up regulation of ATG1/ULK1 kinase complex formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905866) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "up-regulation of ATG1/ULK1 signaling complex formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905866) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "positive regulation of Atg1p signalling complex formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905866) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "positive regulation of ATG1 kinase complex formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905866) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:1905866" + +- [positive regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905866) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "upregulation of ATG1/ULK1 kinase complex assembly" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905866) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "upregulation of ULK1-ATG13-RB1CC1 complex assembly" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905866) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "positive regulation of ULK1-ATG13-FIP200 complex assembly" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905866) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "up regulation of ULK1-ATG13-FIP200 complex formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905866) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "activation of ULK1-ATG13-FIP200 complex formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905866) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "up regulation of ATG1/ULK1 signaling complex formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905866) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "upregulation of ATG1-ATG13 complex assembly" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905866) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that activates or increases the frequency, rate or extent of Atg1/ULK1 kinase complex assembly." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:mf" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:autophagy" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:26567215" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GO_REF:0000058" + +- [positive regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905866) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "up-regulation of ULK1-ATG13-RB1CC1 complex assembly" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905866) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "up-regulation of ATG1/ULK1 kinase complex assembly" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905866) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "activation of ATG1-ATG13 complex assembly" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905866) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "positive regulation of ATG1 kinase complex assembly" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905866) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "upregulation of ULK1 signaling complex assembly" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- Class: [positive regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905866) + +- [positive regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905866) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([positively regulates](http://purl.obolibrary.org/obo/RO_0002213) some [Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1904745)) + +- [positive regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905866) SubClassOf [regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905864) + +- [positive regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905866) SubClassOf [positively regulates](http://purl.obolibrary.org/obo/RO_0002213) some [Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1904745) + +- [positive regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905866) SubClassOf [positive regulation of protein-containing complex assembly](http://purl.obolibrary.org/obo/GO_0031334) + + + +### positive regulation of L-glutamate import across plasma membrane `http://purl.obolibrary.org/obo/GO_0002038` + +#### Added +- [positive regulation of L-glutamate import across plasma membrane](http://purl.obolibrary.org/obo/GO_0002038) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "upregulation of L-glutamate uptake" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of L-glutamate import across plasma membrane](http://purl.obolibrary.org/obo/GO_0002038) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0002038" + +- [positive regulation of L-glutamate import across plasma membrane](http://purl.obolibrary.org/obo/GO_0002038) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "positive regulation of L-glutamate uptake" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of L-glutamate import across plasma membrane](http://purl.obolibrary.org/obo/GO_0002038) [label](http://www.w3.org/2000/01/rdf-schema#label) "positive regulation of L-glutamate import across plasma membrane" + +- [positive regulation of L-glutamate import across plasma membrane](http://purl.obolibrary.org/obo/GO_0002038) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "positive regulation of L-glutamate import" + +- [positive regulation of L-glutamate import across plasma membrane](http://purl.obolibrary.org/obo/GO_0002038) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "up-regulation of L-glutamate transport" + +- [positive regulation of L-glutamate import across plasma membrane](http://purl.obolibrary.org/obo/GO_0002038) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "upregulation of L-glutamate import" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of L-glutamate import across plasma membrane](http://purl.obolibrary.org/obo/GO_0002038) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "al" + +- [positive regulation of L-glutamate import across plasma membrane](http://purl.obolibrary.org/obo/GO_0002038) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "activation of L-glutamate transport" + +- [positive regulation of L-glutamate import across plasma membrane](http://purl.obolibrary.org/obo/GO_0002038) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "stimulation of L-glutamate transport" + +- [positive regulation of L-glutamate import across plasma membrane](http://purl.obolibrary.org/obo/GO_0002038) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "up regulation of L-glutamate transport" + +- [positive regulation of L-glutamate import across plasma membrane](http://purl.obolibrary.org/obo/GO_0002038) [has_alternative_id](http://www.geneontology.org/formats/oboInOwl#hasAlternativeId) "GO:1900922" + +- [positive regulation of L-glutamate import across plasma membrane](http://purl.obolibrary.org/obo/GO_0002038) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "upregulation of L-glutamate transport" + +- [positive regulation of L-glutamate import across plasma membrane](http://purl.obolibrary.org/obo/GO_0002038) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "up-regulation of L-glutamate import" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of L-glutamate import across plasma membrane](http://purl.obolibrary.org/obo/GO_0002038) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "positive regulation of L-glutamate transport" + +- [positive regulation of L-glutamate import across plasma membrane](http://purl.obolibrary.org/obo/GO_0002038) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2012-06-13T07:34:38Z" + +- [positive regulation of L-glutamate import across plasma membrane](http://purl.obolibrary.org/obo/GO_0002038) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that activates or increases the frequency, rate or extent of L-glutamate import into a cell." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of L-glutamate import across plasma membrane](http://purl.obolibrary.org/obo/GO_0002038) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "up-regulation of L-glutamate uptake" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of L-glutamate import across plasma membrane](http://purl.obolibrary.org/obo/GO_0002038) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" + +- [positive regulation of L-glutamate import across plasma membrane](http://purl.obolibrary.org/obo/GO_0002038) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "up regulation of L-glutamate import" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of L-glutamate import across plasma membrane](http://purl.obolibrary.org/obo/GO_0002038) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "activation of L-glutamate uptake" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of L-glutamate import across plasma membrane](http://purl.obolibrary.org/obo/GO_0002038) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "up regulation of L-glutamate uptake" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of L-glutamate import across plasma membrane](http://purl.obolibrary.org/obo/GO_0002038) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "activation of L-glutamate import" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- Class: [positive regulation of L-glutamate import across plasma membrane](http://purl.obolibrary.org/obo/GO_0002038) + +- [positive regulation of L-glutamate import across plasma membrane](http://purl.obolibrary.org/obo/GO_0002038) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([positively regulates](http://purl.obolibrary.org/obo/RO_0002213) some [L-glutamate import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098712)) + +- [positive regulation of L-glutamate import across plasma membrane](http://purl.obolibrary.org/obo/GO_0002038) SubClassOf [positive regulation of amino acid transport](http://purl.obolibrary.org/obo/GO_0051957) + +- [positive regulation of L-glutamate import across plasma membrane](http://purl.obolibrary.org/obo/GO_0002038) SubClassOf [positive regulation of transmembrane transport](http://purl.obolibrary.org/obo/GO_0034764) + +- [positive regulation of L-glutamate import across plasma membrane](http://purl.obolibrary.org/obo/GO_0002038) SubClassOf [regulation of L-glutamate import across plasma membrane](http://purl.obolibrary.org/obo/GO_0002036) + +- [positive regulation of L-glutamate import across plasma membrane](http://purl.obolibrary.org/obo/GO_0002038) SubClassOf [positively regulates](http://purl.obolibrary.org/obo/RO_0002213) some [L-glutamate import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098712) + + +### positive regulation of RNA biosynthetic process `http://purl.obolibrary.org/obo/GO_1902680` +#### Removed +- [positive regulation of RNA biosynthetic process](http://purl.obolibrary.org/obo/GO_1902680) SubClassOf [positive regulation of biosynthetic process](http://purl.obolibrary.org/obo/GO_0009891) + +#### Added +- [positive regulation of RNA biosynthetic process](http://purl.obolibrary.org/obo/GO_1902680) SubClassOf [positive regulation of macromolecule biosynthetic process](http://purl.obolibrary.org/obo/GO_0010557) + + +### positive regulation of RNA export from nucleus `http://purl.obolibrary.org/obo/GO_0046833` + +#### Added +- [positive regulation of RNA export from nucleus](http://purl.obolibrary.org/obo/GO_0046833) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "upregulation of RNA export from nucleus" + +- [positive regulation of RNA export from nucleus](http://purl.obolibrary.org/obo/GO_0046833) [label](http://www.w3.org/2000/01/rdf-schema#label) "positive regulation of RNA export from nucleus" + +- [positive regulation of RNA export from nucleus](http://purl.obolibrary.org/obo/GO_0046833) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" + +- [positive regulation of RNA export from nucleus](http://purl.obolibrary.org/obo/GO_0046833) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "stimulation of RNA export from nucleus" + +- [positive regulation of RNA export from nucleus](http://purl.obolibrary.org/obo/GO_0046833) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "positive regulation of RNA export out of nucleus" + +- [positive regulation of RNA export from nucleus](http://purl.obolibrary.org/obo/GO_0046833) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "positive regulation of RNA-nucleus export" + +- [positive regulation of RNA export from nucleus](http://purl.obolibrary.org/obo/GO_0046833) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "activation of RNA export from nucleus" + +- [positive regulation of RNA export from nucleus](http://purl.obolibrary.org/obo/GO_0046833) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0046833" + +- [positive regulation of RNA export from nucleus](http://purl.obolibrary.org/obo/GO_0046833) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "positive regulation of RNA export from cell nucleus" + +- [positive regulation of RNA export from nucleus](http://purl.obolibrary.org/obo/GO_0046833) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that activates or increases the frequency, rate or extent of directed movement of RNA from the nucleus into the cytoplasm." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:bf" + +- [positive regulation of RNA export from nucleus](http://purl.obolibrary.org/obo/GO_0046833) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "up-regulation of RNA export from nucleus" + +- [positive regulation of RNA export from nucleus](http://purl.obolibrary.org/obo/GO_0046833) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "positive regulation of RNA transport from nucleus to cytoplasm" + +- [positive regulation of RNA export from nucleus](http://purl.obolibrary.org/obo/GO_0046833) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "up regulation of RNA export from nucleus" + +- Class: [positive regulation of RNA export from nucleus](http://purl.obolibrary.org/obo/GO_0046833) + +- [positive regulation of RNA export from nucleus](http://purl.obolibrary.org/obo/GO_0046833) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([positively regulates](http://purl.obolibrary.org/obo/RO_0002213) some [RNA export from nucleus](http://purl.obolibrary.org/obo/GO_0006405)) + +- [positive regulation of RNA export from nucleus](http://purl.obolibrary.org/obo/GO_0046833) SubClassOf [regulation of RNA export from nucleus](http://purl.obolibrary.org/obo/GO_0046831) + +- [positive regulation of RNA export from nucleus](http://purl.obolibrary.org/obo/GO_0046833) SubClassOf [positively regulates](http://purl.obolibrary.org/obo/RO_0002213) some [RNA export from nucleus](http://purl.obolibrary.org/obo/GO_0006405) + +- [positive regulation of RNA export from nucleus](http://purl.obolibrary.org/obo/GO_0046833) SubClassOf [positive regulation of nucleocytoplasmic transport](http://purl.obolibrary.org/obo/GO_0046824) + + +### positive regulation of RNA import into nucleus `http://purl.obolibrary.org/obo/GO_0046830` + +#### Added +- [positive regulation of RNA import into nucleus](http://purl.obolibrary.org/obo/GO_0046830) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "activation of RNA import into nucleus" + +- [positive regulation of RNA import into nucleus](http://purl.obolibrary.org/obo/GO_0046830) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "positive regulation of RNA transport from cytoplasm to nucleus" + +- [positive regulation of RNA import into nucleus](http://purl.obolibrary.org/obo/GO_0046830) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "positive regulation of RNA-nucleus import" + +- [positive regulation of RNA import into nucleus](http://purl.obolibrary.org/obo/GO_0046830) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" + +- [positive regulation of RNA import into nucleus](http://purl.obolibrary.org/obo/GO_0046830) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "positive regulation of RNA import into cell nucleus" + +- [positive regulation of RNA import into nucleus](http://purl.obolibrary.org/obo/GO_0046830) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "up-regulation of RNA import into nucleus" + +- [positive regulation of RNA import into nucleus](http://purl.obolibrary.org/obo/GO_0046830) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "up regulation of RNA import into nucleus" + +- [positive regulation of RNA import into nucleus](http://purl.obolibrary.org/obo/GO_0046830) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "stimulation of RNA import into nucleus" + +- [positive regulation of RNA import into nucleus](http://purl.obolibrary.org/obo/GO_0046830) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0046830" + +- [positive regulation of RNA import into nucleus](http://purl.obolibrary.org/obo/GO_0046830) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that activates or increases the frequency, rate or extent of movement of RNA from the cytoplasm into the nucleus." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:bf" + +- [positive regulation of RNA import into nucleus](http://purl.obolibrary.org/obo/GO_0046830) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "upregulation of RNA import into nucleus" + +- [positive regulation of RNA import into nucleus](http://purl.obolibrary.org/obo/GO_0046830) [label](http://www.w3.org/2000/01/rdf-schema#label) "positive regulation of RNA import into nucleus" + +- Class: [positive regulation of RNA import into nucleus](http://purl.obolibrary.org/obo/GO_0046830) + +- [positive regulation of RNA import into nucleus](http://purl.obolibrary.org/obo/GO_0046830) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([positively regulates](http://purl.obolibrary.org/obo/RO_0002213) some [RNA import into nucleus](http://purl.obolibrary.org/obo/GO_0006404)) + +- [positive regulation of RNA import into nucleus](http://purl.obolibrary.org/obo/GO_0046830) SubClassOf [positive regulation of nucleocytoplasmic transport](http://purl.obolibrary.org/obo/GO_0046824) + +- [positive regulation of RNA import into nucleus](http://purl.obolibrary.org/obo/GO_0046830) SubClassOf [regulation of RNA import into nucleus](http://purl.obolibrary.org/obo/GO_0046828) + +- [positive regulation of RNA import into nucleus](http://purl.obolibrary.org/obo/GO_0046830) SubClassOf [positively regulates](http://purl.obolibrary.org/obo/RO_0002213) some [RNA import into nucleus](http://purl.obolibrary.org/obo/GO_0006404) + + +### positive regulation of anterograde dense core granule transport `http://purl.obolibrary.org/obo/GO_1901953` + +#### Added +- [positive regulation of anterograde dense core granule transport](http://purl.obolibrary.org/obo/GO_1901953) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "up-regulation of anterograde dense core granule transport" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of anterograde dense core granule transport](http://purl.obolibrary.org/obo/GO_1901953) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2013-02-19T13:36:35Z" + +- [positive regulation of anterograde dense core granule transport](http://purl.obolibrary.org/obo/GO_1901953) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "upregulation of anterograde dense core granule transport" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of anterograde dense core granule transport](http://purl.obolibrary.org/obo/GO_1901953) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that activates or increases the frequency, rate or extent of anterograde dense core granule transport." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:23358451" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:kmv" + +- [positive regulation of anterograde dense core granule transport](http://purl.obolibrary.org/obo/GO_1901953) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "up regulation of anterograde dense core granule transport" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of anterograde dense core granule transport](http://purl.obolibrary.org/obo/GO_1901953) [label](http://www.w3.org/2000/01/rdf-schema#label) "positive regulation of anterograde dense core granule transport" + +- [positive regulation of anterograde dense core granule transport](http://purl.obolibrary.org/obo/GO_1901953) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "activation of anterograde dense core granule transport" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of anterograde dense core granule transport](http://purl.obolibrary.org/obo/GO_1901953) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" + +- [positive regulation of anterograde dense core granule transport](http://purl.obolibrary.org/obo/GO_1901953) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "pr" + +- [positive regulation of anterograde dense core granule transport](http://purl.obolibrary.org/obo/GO_1901953) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:1901953" + +- Class: [positive regulation of anterograde dense core granule transport](http://purl.obolibrary.org/obo/GO_1901953) + +- [positive regulation of anterograde dense core granule transport](http://purl.obolibrary.org/obo/GO_1901953) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([positively regulates](http://purl.obolibrary.org/obo/RO_0002213) some [anterograde neuronal dense core vesicle transport](http://purl.obolibrary.org/obo/GO_1990048)) + +- [positive regulation of anterograde dense core granule transport](http://purl.obolibrary.org/obo/GO_1901953) SubClassOf [positively regulates](http://purl.obolibrary.org/obo/RO_0002213) some [anterograde neuronal dense core vesicle transport](http://purl.obolibrary.org/obo/GO_1990048) + +- [positive regulation of anterograde dense core granule transport](http://purl.obolibrary.org/obo/GO_1901953) SubClassOf [positive regulation of dense core granule transport](http://purl.obolibrary.org/obo/GO_1904811) + +- [positive regulation of anterograde dense core granule transport](http://purl.obolibrary.org/obo/GO_1901953) SubClassOf [positive regulation of vesicle transport along microtubule](http://purl.obolibrary.org/obo/GO_1901610) + +- [positive regulation of anterograde dense core granule transport](http://purl.obolibrary.org/obo/GO_1901953) SubClassOf [regulation of anterograde dense core granule transport](http://purl.obolibrary.org/obo/GO_1901951) + + +### positive regulation of autophagic cell death `http://purl.obolibrary.org/obo/GO_1904094` +#### Removed +- [positive regulation of autophagic cell death](http://purl.obolibrary.org/obo/GO_1904094) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "upregulation of autophagic cell death" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of autophagic cell death](http://purl.obolibrary.org/obo/GO_1904094) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that activates or increases the frequency, rate or extent of autophagic cell death." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:bhm" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:25736836" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GO_REF:0000058" + +- [positive regulation of autophagic cell death](http://purl.obolibrary.org/obo/GO_1904094) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "activation of autophagic cell death" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of autophagic cell death](http://purl.obolibrary.org/obo/GO_1904094) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:1904094" + +- [positive regulation of autophagic cell death](http://purl.obolibrary.org/obo/GO_1904094) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2015-03-26T16:41:45Z" + +- [positive regulation of autophagic cell death](http://purl.obolibrary.org/obo/GO_1904094) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" + +- [positive regulation of autophagic cell death](http://purl.obolibrary.org/obo/GO_1904094) [label](http://www.w3.org/2000/01/rdf-schema#label) "positive regulation of autophagic cell death" + +- [positive regulation of autophagic cell death](http://purl.obolibrary.org/obo/GO_1904094) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "bhm" + +- [positive regulation of autophagic cell death](http://purl.obolibrary.org/obo/GO_1904094) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "up-regulation of programmed cell death by macroautophagy" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of autophagic cell death](http://purl.obolibrary.org/obo/GO_1904094) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "positive regulation of programmed cell death by macroautophagy" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of autophagic cell death](http://purl.obolibrary.org/obo/GO_1904094) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "upregulation of programmed cell death by macroautophagy" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of autophagic cell death](http://purl.obolibrary.org/obo/GO_1904094) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "positive regulation of type II programmed cell death" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of autophagic cell death](http://purl.obolibrary.org/obo/GO_1904094) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "up-regulation of autophagic cell death" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of autophagic cell death](http://purl.obolibrary.org/obo/GO_1904094) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "up regulation of programmed cell death by macroautophagy" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of autophagic cell death](http://purl.obolibrary.org/obo/GO_1904094) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "activation of programmed cell death by macroautophagy" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of autophagic cell death](http://purl.obolibrary.org/obo/GO_1904094) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "upregulation of type II programmed cell death" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of autophagic cell death](http://purl.obolibrary.org/obo/GO_1904094) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "up-regulation of type II programmed cell death" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of autophagic cell death](http://purl.obolibrary.org/obo/GO_1904094) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "up regulation of type II programmed cell death" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of autophagic cell death](http://purl.obolibrary.org/obo/GO_1904094) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "up regulation of autophagic cell death" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of autophagic cell death](http://purl.obolibrary.org/obo/GO_1904094) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "activation of type II programmed cell death" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- Class: [positive regulation of autophagic cell death](http://purl.obolibrary.org/obo/GO_1904094) + +- [positive regulation of autophagic cell death](http://purl.obolibrary.org/obo/GO_1904094) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([positively regulates](http://purl.obolibrary.org/obo/RO_0002213) some [autophagic cell death](http://purl.obolibrary.org/obo/GO_0048102)) + +- [positive regulation of autophagic cell death](http://purl.obolibrary.org/obo/GO_1904094) SubClassOf [regulation of autophagic cell death](http://purl.obolibrary.org/obo/GO_1904092) + +- [positive regulation of autophagic cell death](http://purl.obolibrary.org/obo/GO_1904094) SubClassOf [positive regulation of programmed cell death](http://purl.obolibrary.org/obo/GO_0043068) + +- [positive regulation of autophagic cell death](http://purl.obolibrary.org/obo/GO_1904094) SubClassOf [positively regulates](http://purl.obolibrary.org/obo/RO_0002213) some [autophagic cell death](http://purl.obolibrary.org/obo/GO_0048102) + + + +### positive regulation of autophagosome assembly `http://purl.obolibrary.org/obo/GO_2000786` +#### Removed +- [positive regulation of autophagosome assembly](http://purl.obolibrary.org/obo/GO_2000786) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:2000786" + +- [positive regulation of autophagosome assembly](http://purl.obolibrary.org/obo/GO_2000786) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "positive regulation of PAS formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:obol" + +- [positive regulation of autophagosome assembly](http://purl.obolibrary.org/obo/GO_2000786) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" + +- [positive regulation of autophagosome assembly](http://purl.obolibrary.org/obo/GO_2000786) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "positive regulation of autophagic vacuole assembly" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:autophagy" + +- [positive regulation of autophagosome assembly](http://purl.obolibrary.org/obo/GO_2000786) [label](http://www.w3.org/2000/01/rdf-schema#label) "positive regulation of autophagosome assembly" + +- [positive regulation of autophagosome assembly](http://purl.obolibrary.org/obo/GO_2000786) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "rl" + +- [positive regulation of autophagosome assembly](http://purl.obolibrary.org/obo/GO_2000786) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "positive regulation of autophagic vacuole formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:obol" + +- [positive regulation of autophagosome assembly](http://purl.obolibrary.org/obo/GO_2000786) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2011-06-24T11:19:12Z" + +- [positive regulation of autophagosome assembly](http://purl.obolibrary.org/obo/GO_2000786) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "positive regulation of autophagosome biosynthesis" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:obol" + +- [positive regulation of autophagosome assembly](http://purl.obolibrary.org/obo/GO_2000786) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that activates or increases the frequency, rate or extent of autophagic vacuole assembly." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:autophagy" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:BHF" + +- [positive regulation of autophagosome assembly](http://purl.obolibrary.org/obo/GO_2000786) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "positive regulation of autophagosome formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:obol" + +- Class: [positive regulation of autophagosome assembly](http://purl.obolibrary.org/obo/GO_2000786) + +- [positive regulation of autophagosome assembly](http://purl.obolibrary.org/obo/GO_2000786) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([positively regulates](http://purl.obolibrary.org/obo/RO_0002213) some [autophagosome assembly](http://purl.obolibrary.org/obo/GO_0000045)) + +- [positive regulation of autophagosome assembly](http://purl.obolibrary.org/obo/GO_2000786) SubClassOf [positively regulates](http://purl.obolibrary.org/obo/RO_0002213) some [autophagosome assembly](http://purl.obolibrary.org/obo/GO_0000045) + +- [positive regulation of autophagosome assembly](http://purl.obolibrary.org/obo/GO_2000786) SubClassOf [positive regulation of vacuole organization](http://purl.obolibrary.org/obo/GO_0044090) + +- [positive regulation of autophagosome assembly](http://purl.obolibrary.org/obo/GO_2000786) SubClassOf [positive regulation of organelle assembly](http://purl.obolibrary.org/obo/GO_1902117) + +- [positive regulation of autophagosome assembly](http://purl.obolibrary.org/obo/GO_2000786) SubClassOf [positive regulation of macroautophagy](http://purl.obolibrary.org/obo/GO_0016239) + +- [positive regulation of autophagosome assembly](http://purl.obolibrary.org/obo/GO_2000786) SubClassOf [regulation of autophagosome assembly](http://purl.obolibrary.org/obo/GO_2000785) + + + +### positive regulation of autophagy `http://purl.obolibrary.org/obo/GO_0010508` +#### Removed +- [positive regulation of autophagy](http://purl.obolibrary.org/obo/GO_0010508) [label](http://www.w3.org/2000/01/rdf-schema#label) "positive regulation of autophagy" + +- [positive regulation of autophagy](http://purl.obolibrary.org/obo/GO_0010508) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that activates, maintains or increases the rate of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dph" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:tb" + +- [positive regulation of autophagy](http://purl.obolibrary.org/obo/GO_0010508) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" + +- [positive regulation of autophagy](http://purl.obolibrary.org/obo/GO_0010508) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0010508" + +- Class: [positive regulation of autophagy](http://purl.obolibrary.org/obo/GO_0010508) + +- [positive regulation of autophagy](http://purl.obolibrary.org/obo/GO_0010508) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([positively regulates](http://purl.obolibrary.org/obo/RO_0002213) some [autophagy](http://purl.obolibrary.org/obo/GO_0006914)) + +- [positive regulation of autophagy](http://purl.obolibrary.org/obo/GO_0010508) SubClassOf [regulation of autophagy](http://purl.obolibrary.org/obo/GO_0010506) + +- [positive regulation of autophagy](http://purl.obolibrary.org/obo/GO_0010508) SubClassOf [positively regulates](http://purl.obolibrary.org/obo/RO_0002213) some [autophagy](http://purl.obolibrary.org/obo/GO_0006914) + +- [positive regulation of autophagy](http://purl.obolibrary.org/obo/GO_0010508) SubClassOf [positive regulation of cellular catabolic process](http://purl.obolibrary.org/obo/GO_0031331) + + + +### positive regulation of calcium ion export across plasma membrane `http://purl.obolibrary.org/obo/GO_1905914` + +#### Added +- [positive regulation of calcium ion export across plasma membrane](http://purl.obolibrary.org/obo/GO_1905914) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "up-regulation of calcium ion export from cell" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of calcium ion export across plasma membrane](http://purl.obolibrary.org/obo/GO_1905914) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "positive regulation of calcium ion export from cell" + +- [positive regulation of calcium ion export across plasma membrane](http://purl.obolibrary.org/obo/GO_1905914) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "up regulation of calcium ion export from cell" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of calcium ion export across plasma membrane](http://purl.obolibrary.org/obo/GO_1905914) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "activation of calcium ion export from cell" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of calcium ion export across plasma membrane](http://purl.obolibrary.org/obo/GO_1905914) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "activation of calcium ion efflux from cell" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of calcium ion export across plasma membrane](http://purl.obolibrary.org/obo/GO_1905914) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "up-regulation of calcium ion efflux from cell" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of calcium ion export across plasma membrane](http://purl.obolibrary.org/obo/GO_1905914) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "up regulation of calcium ion efflux from cell" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of calcium ion export across plasma membrane](http://purl.obolibrary.org/obo/GO_1905914) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:1905914" + +- [positive regulation of calcium ion export across plasma membrane](http://purl.obolibrary.org/obo/GO_1905914) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "upregulation of calcium ion export from cell" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of calcium ion export across plasma membrane](http://purl.obolibrary.org/obo/GO_1905914) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "positive regulation of calcium ion efflux from cell" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of calcium ion export across plasma membrane](http://purl.obolibrary.org/obo/GO_1905914) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "rph" + +- [positive regulation of calcium ion export across plasma membrane](http://purl.obolibrary.org/obo/GO_1905914) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2017-02-07T13:20:56Z" + +- [positive regulation of calcium ion export across plasma membrane](http://purl.obolibrary.org/obo/GO_1905914) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "upregulation of calcium ion efflux from cell" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of calcium ion export across plasma membrane](http://purl.obolibrary.org/obo/GO_1905914) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that activates or increases the frequency, rate or extent of calcium ion export across the plasma membrane." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:BHF_miRNA" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:BHF" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:22362515" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GO_REF:0000058" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:rph" + +- [positive regulation of calcium ion export across plasma membrane](http://purl.obolibrary.org/obo/GO_1905914) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" + +- [positive regulation of calcium ion export across plasma membrane](http://purl.obolibrary.org/obo/GO_1905914) [label](http://www.w3.org/2000/01/rdf-schema#label) "positive regulation of calcium ion export across plasma membrane" + +- Class: [positive regulation of calcium ion export across plasma membrane](http://purl.obolibrary.org/obo/GO_1905914) + +- [positive regulation of calcium ion export across plasma membrane](http://purl.obolibrary.org/obo/GO_1905914) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([positively regulates](http://purl.obolibrary.org/obo/RO_0002213) some [calcium ion export across plasma membrane](http://purl.obolibrary.org/obo/GO_1990034)) + +- [positive regulation of calcium ion export across plasma membrane](http://purl.obolibrary.org/obo/GO_1905914) SubClassOf [positive regulation of calcium ion transmembrane transport](http://purl.obolibrary.org/obo/GO_1904427) + +- [positive regulation of calcium ion export across plasma membrane](http://purl.obolibrary.org/obo/GO_1905914) SubClassOf [positively regulates](http://purl.obolibrary.org/obo/RO_0002213) some [calcium ion export across plasma membrane](http://purl.obolibrary.org/obo/GO_1990034) + +- [positive regulation of calcium ion export across plasma membrane](http://purl.obolibrary.org/obo/GO_1905914) SubClassOf [regulation of calcium ion export across plasma membrane](http://purl.obolibrary.org/obo/GO_1905912) + + +### positive regulation of calcium ion import across plasma membrane `http://purl.obolibrary.org/obo/GO_1905665` + +#### Added +- [positive regulation of calcium ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_1905665) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:1905665" + +- [positive regulation of calcium ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_1905665) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" + +- [positive regulation of calcium ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_1905665) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "An example of this is PPP3CA in human (Q08209) in 17640527 (inferred from direct assay)." + +- [positive regulation of calcium ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_1905665) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2016-11-11T09:26:23Z" + +- [positive regulation of calcium ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_1905665) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "bhm" + +- [positive regulation of calcium ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_1905665) [label](http://www.w3.org/2000/01/rdf-schema#label) "positive regulation of calcium ion import across plasma membrane" + +- [positive regulation of calcium ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_1905665) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that activates or increases the frequency, rate or extent of calcium ion import across plasma membrane." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:17640527" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:bhm" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GO_REF:0000058" + +- [positive regulation of calcium ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_1905665) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "up regulation of calcium ion import across plasma membrane" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of calcium ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_1905665) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "up-regulation of calcium ion import across plasma membrane" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of calcium ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_1905665) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "upregulation of calcium ion import across plasma membrane" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of calcium ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_1905665) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "activation of calcium ion import across plasma membrane" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- Class: [positive regulation of calcium ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_1905665) + +- [positive regulation of calcium ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_1905665) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([positively regulates](http://purl.obolibrary.org/obo/RO_0002213) some [calcium ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098703)) + +- [positive regulation of calcium ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_1905665) SubClassOf [positively regulates](http://purl.obolibrary.org/obo/RO_0002213) some [calcium ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098703) + +- [positive regulation of calcium ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_1905665) SubClassOf [regulation of calcium ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_1905664) + +- [positive regulation of calcium ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_1905665) SubClassOf [positive regulation of calcium ion transmembrane transport](http://purl.obolibrary.org/obo/GO_1904427) + + +### positive regulation of calcium-mediated signaling involved in cellular response to calcium ion `http://purl.obolibrary.org/obo/GO_1901197` + +#### Added +- [positive regulation of calcium-mediated signaling involved in cellular response to calcium ion](http://purl.obolibrary.org/obo/GO_1901197) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "activation of calcium-mediated signaling involved in cellular response to calcium ion" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of calcium-mediated signaling involved in cellular response to calcium ion](http://purl.obolibrary.org/obo/GO_1901197) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "upregulation of calcium-mediated signaling involved in cellular response to calcium ion" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of calcium-mediated signaling involved in cellular response to calcium ion](http://purl.obolibrary.org/obo/GO_1901197) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:1901197" + +- [positive regulation of calcium-mediated signaling involved in cellular response to calcium ion](http://purl.obolibrary.org/obo/GO_1901197) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "up regulation of calcium-mediated signaling involved in cellular response to Ca2+ ion" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of calcium-mediated signaling involved in cellular response to calcium ion](http://purl.obolibrary.org/obo/GO_1901197) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "stimulation of calcium-mediated signaling involved in cellular response to Ca2+ ion" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of calcium-mediated signaling involved in cellular response to calcium ion](http://purl.obolibrary.org/obo/GO_1901197) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any positive regulation of calcium-mediated signaling that is involved in cellular response to calcium ion." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of calcium-mediated signaling involved in cellular response to calcium ion](http://purl.obolibrary.org/obo/GO_1901197) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2012-07-27T10:57:56Z" + +- [positive regulation of calcium-mediated signaling involved in cellular response to calcium ion](http://purl.obolibrary.org/obo/GO_1901197) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "stimulation of calcium-mediated signaling involved in cellular response to calcium ion" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of calcium-mediated signaling involved in cellular response to calcium ion](http://purl.obolibrary.org/obo/GO_1901197) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "up-regulation of calcium-mediated signaling involved in response to calcium ion" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of calcium-mediated signaling involved in cellular response to calcium ion](http://purl.obolibrary.org/obo/GO_1901197) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" + +- [positive regulation of calcium-mediated signaling involved in cellular response to calcium ion](http://purl.obolibrary.org/obo/GO_1901197) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "positive regulation of calcium-mediated signalling involved in cellular response to Ca2+ ion" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of calcium-mediated signaling involved in cellular response to calcium ion](http://purl.obolibrary.org/obo/GO_1901197) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "activation of calcium-mediated signaling involved in cellular response to Ca2+ ion" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of calcium-mediated signaling involved in cellular response to calcium ion](http://purl.obolibrary.org/obo/GO_1901197) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "al" + +- [positive regulation of calcium-mediated signaling involved in cellular response to calcium ion](http://purl.obolibrary.org/obo/GO_1901197) [label](http://www.w3.org/2000/01/rdf-schema#label) "positive regulation of calcium-mediated signaling involved in cellular response to calcium ion" + +- [positive regulation of calcium-mediated signaling involved in cellular response to calcium ion](http://purl.obolibrary.org/obo/GO_1901197) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "positive regulation of calcium-mediated signaling involved in cellular response to Ca2+ ion" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of calcium-mediated signaling involved in cellular response to calcium ion](http://purl.obolibrary.org/obo/GO_1901197) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "positive regulation of calcium-mediated signalling involved in cellular response to calcium ion" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of calcium-mediated signaling involved in cellular response to calcium ion](http://purl.obolibrary.org/obo/GO_1901197) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "up regulation of calcium-mediated signaling involved in cellular response to calcium ion" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of calcium-mediated signaling involved in cellular response to calcium ion](http://purl.obolibrary.org/obo/GO_1901197) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "up-regulation of calcium-mediated signaling involved in cellular response to Ca2+ ion" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of calcium-mediated signaling involved in cellular response to calcium ion](http://purl.obolibrary.org/obo/GO_1901197) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "upregulation of calcium-mediated signaling involved in cellular response to Ca2+ ion" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- Class: [positive regulation of calcium-mediated signaling involved in cellular response to calcium ion](http://purl.obolibrary.org/obo/GO_1901197) + +- [positive regulation of calcium-mediated signaling involved in cellular response to calcium ion](http://purl.obolibrary.org/obo/GO_1901197) EquivalentTo [positive regulation of calcium-mediated signaling](http://purl.obolibrary.org/obo/GO_0050850) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [cellular response to calcium ion](http://purl.obolibrary.org/obo/GO_0071277)) + +- [positive regulation of calcium-mediated signaling involved in cellular response to calcium ion](http://purl.obolibrary.org/obo/GO_1901197) SubClassOf [positive regulation of calcium-mediated signaling](http://purl.obolibrary.org/obo/GO_0050850) + +- [positive regulation of calcium-mediated signaling involved in cellular response to calcium ion](http://purl.obolibrary.org/obo/GO_1901197) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [cellular response to calcium ion](http://purl.obolibrary.org/obo/GO_0071277) + + +### positive regulation of cell morphogenesis involved in differentiation `http://purl.obolibrary.org/obo/GO_0010770` +#### Removed +- [positive regulation of cell morphogenesis involved in differentiation](http://purl.obolibrary.org/obo/GO_0010770) [label](http://www.w3.org/2000/01/rdf-schema#label) "positive regulation of cell morphogenesis involved in differentiation" + +- [positive regulation of cell morphogenesis involved in differentiation](http://purl.obolibrary.org/obo/GO_0010770) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([positively regulates](http://purl.obolibrary.org/obo/RO_0002213) some [cell morphogenesis involved in differentiation](http://purl.obolibrary.org/obo/GO_0000904)) + +- [positive regulation of cell morphogenesis involved in differentiation](http://purl.obolibrary.org/obo/GO_0010770) SubClassOf [positively regulates](http://purl.obolibrary.org/obo/RO_0002213) some [cell morphogenesis involved in differentiation](http://purl.obolibrary.org/obo/GO_0000904) + +- [positive regulation of cell morphogenesis involved in differentiation](http://purl.obolibrary.org/obo/GO_0010770) SubClassOf [regulation of cell morphogenesis involved in differentiation](http://purl.obolibrary.org/obo/GO_0010769) + +#### Added +- [positive regulation of cell morphogenesis involved in differentiation](http://purl.obolibrary.org/obo/GO_0010770) [label](http://www.w3.org/2000/01/rdf-schema#label) "positive regulation of cell morphogenesis" + +- [positive regulation of cell morphogenesis involved in differentiation](http://purl.obolibrary.org/obo/GO_0010770) [term tracker item](http://purl.obolibrary.org/obo/IAO_0000233) "https://github.com/geneontology/go-ontology/issues/24299"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI) + +- [positive regulation of cell morphogenesis involved in differentiation](http://purl.obolibrary.org/obo/GO_0010770) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([positively regulates](http://purl.obolibrary.org/obo/RO_0002213) some [cell morphogenesis](http://purl.obolibrary.org/obo/GO_0000902)) + +- [positive regulation of cell morphogenesis involved in differentiation](http://purl.obolibrary.org/obo/GO_0010770) SubClassOf [positively regulates](http://purl.obolibrary.org/obo/RO_0002213) some [cell morphogenesis](http://purl.obolibrary.org/obo/GO_0000902) + +- [positive regulation of cell morphogenesis involved in differentiation](http://purl.obolibrary.org/obo/GO_0010770) SubClassOf [regulation of cell morphogenesis](http://purl.obolibrary.org/obo/GO_0022604) + + +### positive regulation of cell projection organization `http://purl.obolibrary.org/obo/GO_0031346` + +#### Added +- [positive regulation of cell projection organization](http://purl.obolibrary.org/obo/GO_0031346) SubClassOf [positive regulation of cell population proliferation](http://purl.obolibrary.org/obo/GO_0008284) + + +### positive regulation of cytoplasmic translation `http://purl.obolibrary.org/obo/GO_2000767` + +#### Added +- [positive regulation of cytoplasmic translation](http://purl.obolibrary.org/obo/GO_2000767) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" + +- [positive regulation of cytoplasmic translation](http://purl.obolibrary.org/obo/GO_2000767) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that activates or increases the frequency, rate or extent of cytoplasmic translation." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:obol" + +- [positive regulation of cytoplasmic translation](http://purl.obolibrary.org/obo/GO_2000767) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "vw" + +- [positive regulation of cytoplasmic translation](http://purl.obolibrary.org/obo/GO_2000767) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2011-06-20T10:39:26Z" + +- [positive regulation of cytoplasmic translation](http://purl.obolibrary.org/obo/GO_2000767) [label](http://www.w3.org/2000/01/rdf-schema#label) "positive regulation of cytoplasmic translation" + +- [positive regulation of cytoplasmic translation](http://purl.obolibrary.org/obo/GO_2000767) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:2000767" + +- Class: [positive regulation of cytoplasmic translation](http://purl.obolibrary.org/obo/GO_2000767) + +- [positive regulation of cytoplasmic translation](http://purl.obolibrary.org/obo/GO_2000767) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([positively regulates](http://purl.obolibrary.org/obo/RO_0002213) some [cytoplasmic translation](http://purl.obolibrary.org/obo/GO_0002181)) + +- [positive regulation of cytoplasmic translation](http://purl.obolibrary.org/obo/GO_2000767) SubClassOf [positively regulates](http://purl.obolibrary.org/obo/RO_0002213) some [cytoplasmic translation](http://purl.obolibrary.org/obo/GO_0002181) + +- [positive regulation of cytoplasmic translation](http://purl.obolibrary.org/obo/GO_2000767) SubClassOf [positive regulation of translation](http://purl.obolibrary.org/obo/GO_0045727) + +- [positive regulation of cytoplasmic translation](http://purl.obolibrary.org/obo/GO_2000767) SubClassOf [regulation of cytoplasmic translation](http://purl.obolibrary.org/obo/GO_2000765) + + +### positive regulation of cytoplasmic translational elongation `http://purl.obolibrary.org/obo/GO_1900249` + +#### Added +- [positive regulation of cytoplasmic translational elongation](http://purl.obolibrary.org/obo/GO_1900249) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2012-04-03T05:07:24Z" + +- [positive regulation of cytoplasmic translational elongation](http://purl.obolibrary.org/obo/GO_1900249) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:1900249" + +- [positive regulation of cytoplasmic translational elongation](http://purl.obolibrary.org/obo/GO_1900249) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "upregulation of cytoplasmic translational elongation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of cytoplasmic translational elongation](http://purl.obolibrary.org/obo/GO_1900249) [label](http://www.w3.org/2000/01/rdf-schema#label) "positive regulation of cytoplasmic translational elongation" + +- [positive regulation of cytoplasmic translational elongation](http://purl.obolibrary.org/obo/GO_1900249) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "activation of cytoplasmic translational elongation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of cytoplasmic translational elongation](http://purl.obolibrary.org/obo/GO_1900249) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" + +- [positive regulation of cytoplasmic translational elongation](http://purl.obolibrary.org/obo/GO_1900249) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "up-regulation of cytoplasmic translational elongation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of cytoplasmic translational elongation](http://purl.obolibrary.org/obo/GO_1900249) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "up regulation of cytoplasmic translational elongation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of cytoplasmic translational elongation](http://purl.obolibrary.org/obo/GO_1900249) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "vw" + +- [positive regulation of cytoplasmic translational elongation](http://purl.obolibrary.org/obo/GO_1900249) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that activates or increases the frequency, rate or extent of cytoplasmic translational elongation." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- Class: [positive regulation of cytoplasmic translational elongation](http://purl.obolibrary.org/obo/GO_1900249) + +- [positive regulation of cytoplasmic translational elongation](http://purl.obolibrary.org/obo/GO_1900249) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([positively regulates](http://purl.obolibrary.org/obo/RO_0002213) some [cytoplasmic translational elongation](http://purl.obolibrary.org/obo/GO_0002182)) + +- [positive regulation of cytoplasmic translational elongation](http://purl.obolibrary.org/obo/GO_1900249) SubClassOf [positive regulation of translational elongation](http://purl.obolibrary.org/obo/GO_0045901) + +- [positive regulation of cytoplasmic translational elongation](http://purl.obolibrary.org/obo/GO_1900249) SubClassOf [positively regulates](http://purl.obolibrary.org/obo/RO_0002213) some [cytoplasmic translational elongation](http://purl.obolibrary.org/obo/GO_0002182) + +- [positive regulation of cytoplasmic translational elongation](http://purl.obolibrary.org/obo/GO_1900249) SubClassOf [regulation of cytoplasmic translational elongation](http://purl.obolibrary.org/obo/GO_1900247) + + +### positive regulation of cytoplasmic translational initiation `http://purl.obolibrary.org/obo/GO_1904690` + +#### Added +- [positive regulation of cytoplasmic translational initiation](http://purl.obolibrary.org/obo/GO_1904690) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "upregulation of cytoplasmic translational initiation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of cytoplasmic translational initiation](http://purl.obolibrary.org/obo/GO_1904690) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "up-regulation of cytoplasmic translational initiation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of cytoplasmic translational initiation](http://purl.obolibrary.org/obo/GO_1904690) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "activation of cytoplasmic translational initiation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of cytoplasmic translational initiation](http://purl.obolibrary.org/obo/GO_1904690) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2015-09-25T14:39:50Z" + +- [positive regulation of cytoplasmic translational initiation](http://purl.obolibrary.org/obo/GO_1904690) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that activates or increases the frequency, rate or extent of cytoplasmic translational initiation." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:12242291" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GO_REF:0000058" + +- [positive regulation of cytoplasmic translational initiation](http://purl.obolibrary.org/obo/GO_1904690) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:1904690" + +- [positive regulation of cytoplasmic translational initiation](http://purl.obolibrary.org/obo/GO_1904690) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" + +- [positive regulation of cytoplasmic translational initiation](http://purl.obolibrary.org/obo/GO_1904690) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "up regulation of cytoplasmic translational initiation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of cytoplasmic translational initiation](http://purl.obolibrary.org/obo/GO_1904690) [label](http://www.w3.org/2000/01/rdf-schema#label) "positive regulation of cytoplasmic translational initiation" + +- [positive regulation of cytoplasmic translational initiation](http://purl.obolibrary.org/obo/GO_1904690) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "dos" + +- Class: [positive regulation of cytoplasmic translational initiation](http://purl.obolibrary.org/obo/GO_1904690) + +- [positive regulation of cytoplasmic translational initiation](http://purl.obolibrary.org/obo/GO_1904690) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([positively regulates](http://purl.obolibrary.org/obo/RO_0002213) some [cytoplasmic translational initiation](http://purl.obolibrary.org/obo/GO_0002183)) + +- [positive regulation of cytoplasmic translational initiation](http://purl.obolibrary.org/obo/GO_1904690) SubClassOf [positive regulation of translational initiation](http://purl.obolibrary.org/obo/GO_0045948) + +- [positive regulation of cytoplasmic translational initiation](http://purl.obolibrary.org/obo/GO_1904690) SubClassOf [regulation of cytoplasmic translational initiation](http://purl.obolibrary.org/obo/GO_1904688) + +- [positive regulation of cytoplasmic translational initiation](http://purl.obolibrary.org/obo/GO_1904690) SubClassOf [positively regulates](http://purl.obolibrary.org/obo/RO_0002213) some [cytoplasmic translational initiation](http://purl.obolibrary.org/obo/GO_0002183) + + +### positive regulation of cytoplasmic transport `http://purl.obolibrary.org/obo/GO_1903651` + +#### Added +- [positive regulation of cytoplasmic transport](http://purl.obolibrary.org/obo/GO_1903651) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "upregulation of cytoplasmic transport" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of cytoplasmic transport](http://purl.obolibrary.org/obo/GO_1903651) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "jl" + +- [positive regulation of cytoplasmic transport](http://purl.obolibrary.org/obo/GO_1903651) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "activation of cytoplasmic transport" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of cytoplasmic transport](http://purl.obolibrary.org/obo/GO_1903651) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "activation of cytoplasmic streaming" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of cytoplasmic transport](http://purl.obolibrary.org/obo/GO_1903651) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "upregulation of cytoplasmic streaming" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of cytoplasmic transport](http://purl.obolibrary.org/obo/GO_1903651) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "positive regulation of cytoplasmic streaming" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of cytoplasmic transport](http://purl.obolibrary.org/obo/GO_1903651) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2014-11-24T13:38:34Z" + +- [positive regulation of cytoplasmic transport](http://purl.obolibrary.org/obo/GO_1903651) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "up-regulation of cytoplasmic transport" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of cytoplasmic transport](http://purl.obolibrary.org/obo/GO_1903651) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" + +- [positive regulation of cytoplasmic transport](http://purl.obolibrary.org/obo/GO_1903651) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "up-regulation of cytoplasmic streaming" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of cytoplasmic transport](http://purl.obolibrary.org/obo/GO_1903651) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "up regulation of cytoplasmic streaming" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of cytoplasmic transport](http://purl.obolibrary.org/obo/GO_1903651) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that activates or increases the frequency, rate or extent of cytoplasmic transport." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:25049409" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GO_REF:0000058" + +- [positive regulation of cytoplasmic transport](http://purl.obolibrary.org/obo/GO_1903651) [label](http://www.w3.org/2000/01/rdf-schema#label) "positive regulation of cytoplasmic transport" + +- [positive regulation of cytoplasmic transport](http://purl.obolibrary.org/obo/GO_1903651) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "up regulation of cytoplasmic transport" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of cytoplasmic transport](http://purl.obolibrary.org/obo/GO_1903651) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:1903651" + +- Class: [positive regulation of cytoplasmic transport](http://purl.obolibrary.org/obo/GO_1903651) + +- [positive regulation of cytoplasmic transport](http://purl.obolibrary.org/obo/GO_1903651) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([positively regulates](http://purl.obolibrary.org/obo/RO_0002213) some [cytosolic transport](http://purl.obolibrary.org/obo/GO_0016482)) + +- [positive regulation of cytoplasmic transport](http://purl.obolibrary.org/obo/GO_1903651) SubClassOf [regulation of cytoplasmic transport](http://purl.obolibrary.org/obo/GO_1903649) + +- [positive regulation of cytoplasmic transport](http://purl.obolibrary.org/obo/GO_1903651) SubClassOf [positively regulates](http://purl.obolibrary.org/obo/RO_0002213) some [cytosolic transport](http://purl.obolibrary.org/obo/GO_0016482) + +- [positive regulation of cytoplasmic transport](http://purl.obolibrary.org/obo/GO_1903651) SubClassOf [positive regulation of intracellular transport](http://purl.obolibrary.org/obo/GO_0032388) + + +### positive regulation of dense core granule transport `http://purl.obolibrary.org/obo/GO_1904811` + +#### Added +- [positive regulation of dense core granule transport](http://purl.obolibrary.org/obo/GO_1904811) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "activation of dense core granule transport" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of dense core granule transport](http://purl.obolibrary.org/obo/GO_1904811) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that activates or increases the frequency, rate or extent of dense core granule transport." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:22699897" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GO_REF:0000058" + +- [positive regulation of dense core granule transport](http://purl.obolibrary.org/obo/GO_1904811) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "cdk-5 in C.elegans (G5ECH7) in PMID:22699897 (inferred from mutant phenotype)." + +- [positive regulation of dense core granule transport](http://purl.obolibrary.org/obo/GO_1904811) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "up regulation of dense core granule transport" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of dense core granule transport](http://purl.obolibrary.org/obo/GO_1904811) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "positive regulation of dense core vesicle transport" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of dense core granule transport](http://purl.obolibrary.org/obo/GO_1904811) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "activation of dense core vesicle transport" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of dense core granule transport](http://purl.obolibrary.org/obo/GO_1904811) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:1904811" + +- [positive regulation of dense core granule transport](http://purl.obolibrary.org/obo/GO_1904811) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "upregulation of dense core granule transport" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of dense core granule transport](http://purl.obolibrary.org/obo/GO_1904811) [label](http://www.w3.org/2000/01/rdf-schema#label) "positive regulation of dense core granule transport" + +- [positive regulation of dense core granule transport](http://purl.obolibrary.org/obo/GO_1904811) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "upregulation of dense core vesicle transport" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of dense core granule transport](http://purl.obolibrary.org/obo/GO_1904811) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "up regulation of dense core vesicle transport" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of dense core granule transport](http://purl.obolibrary.org/obo/GO_1904811) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "es" + +- [positive regulation of dense core granule transport](http://purl.obolibrary.org/obo/GO_1904811) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2015-11-11T10:40:25Z" + +- [positive regulation of dense core granule transport](http://purl.obolibrary.org/obo/GO_1904811) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" + +- [positive regulation of dense core granule transport](http://purl.obolibrary.org/obo/GO_1904811) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "up-regulation of dense core vesicle transport" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of dense core granule transport](http://purl.obolibrary.org/obo/GO_1904811) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "up-regulation of dense core granule transport" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- Class: [positive regulation of dense core granule transport](http://purl.obolibrary.org/obo/GO_1904811) + +- [positive regulation of dense core granule transport](http://purl.obolibrary.org/obo/GO_1904811) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([positively regulates](http://purl.obolibrary.org/obo/RO_0002213) some [dense core granule transport](http://purl.obolibrary.org/obo/GO_1901950)) + +- [positive regulation of dense core granule transport](http://purl.obolibrary.org/obo/GO_1904811) SubClassOf [positive regulation of cytoplasmic transport](http://purl.obolibrary.org/obo/GO_1903651) + +- [positive regulation of dense core granule transport](http://purl.obolibrary.org/obo/GO_1904811) SubClassOf [positively regulates](http://purl.obolibrary.org/obo/RO_0002213) some [dense core granule transport](http://purl.obolibrary.org/obo/GO_1901950) + +- [positive regulation of dense core granule transport](http://purl.obolibrary.org/obo/GO_1904811) SubClassOf [regulation of dense core granule transport](http://purl.obolibrary.org/obo/GO_1904809) + + +### positive regulation of gene expression `http://purl.obolibrary.org/obo/GO_0010628` +#### Removed +- [positive regulation of gene expression](http://purl.obolibrary.org/obo/GO_0010628) SubClassOf [positive regulation of macromolecule metabolic process](http://purl.obolibrary.org/obo/GO_0010604) + +#### Added +- [positive regulation of gene expression](http://purl.obolibrary.org/obo/GO_0010628) SubClassOf [positive regulation of macromolecule biosynthetic process](http://purl.obolibrary.org/obo/GO_0010557) + + +### positive regulation of glycine import across plasma membrane `http://purl.obolibrary.org/obo/GO_1900925` + +#### Added +- [positive regulation of glycine import across plasma membrane](http://purl.obolibrary.org/obo/GO_1900925) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "up regulation of glycine import" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of glycine import across plasma membrane](http://purl.obolibrary.org/obo/GO_1900925) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:1900925" + +- [positive regulation of glycine import across plasma membrane](http://purl.obolibrary.org/obo/GO_1900925) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "positive regulation of glycine import" + +- [positive regulation of glycine import across plasma membrane](http://purl.obolibrary.org/obo/GO_1900925) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "up-regulation of glycine import" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of glycine import across plasma membrane](http://purl.obolibrary.org/obo/GO_1900925) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that activates or increases the frequency, rate or extent of glycine import." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of glycine import across plasma membrane](http://purl.obolibrary.org/obo/GO_1900925) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" + +- [positive regulation of glycine import across plasma membrane](http://purl.obolibrary.org/obo/GO_1900925) [label](http://www.w3.org/2000/01/rdf-schema#label) "positive regulation of glycine import across plasma membrane" + +- [positive regulation of glycine import across plasma membrane](http://purl.obolibrary.org/obo/GO_1900925) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "al" + +- [positive regulation of glycine import across plasma membrane](http://purl.obolibrary.org/obo/GO_1900925) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "upregulation of glycine import" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of glycine import across plasma membrane](http://purl.obolibrary.org/obo/GO_1900925) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2012-06-13T07:40:40Z" + +- [positive regulation of glycine import across plasma membrane](http://purl.obolibrary.org/obo/GO_1900925) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "activation of glycine import" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- Class: [positive regulation of glycine import across plasma membrane](http://purl.obolibrary.org/obo/GO_1900925) + +- [positive regulation of glycine import across plasma membrane](http://purl.obolibrary.org/obo/GO_1900925) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([positively regulates](http://purl.obolibrary.org/obo/RO_0002213) some [glycine import across plasma membrane](http://purl.obolibrary.org/obo/GO_1903804)) + +- [positive regulation of glycine import across plasma membrane](http://purl.obolibrary.org/obo/GO_1900925) SubClassOf [positive regulation of amino acid transport](http://purl.obolibrary.org/obo/GO_0051957) + +- [positive regulation of glycine import across plasma membrane](http://purl.obolibrary.org/obo/GO_1900925) SubClassOf [regulation of glycine import across plasma membrane](http://purl.obolibrary.org/obo/GO_1900923) + +- [positive regulation of glycine import across plasma membrane](http://purl.obolibrary.org/obo/GO_1900925) SubClassOf [positively regulates](http://purl.obolibrary.org/obo/RO_0002213) some [glycine import across plasma membrane](http://purl.obolibrary.org/obo/GO_1903804) + +- [positive regulation of glycine import across plasma membrane](http://purl.obolibrary.org/obo/GO_1900925) SubClassOf [positive regulation of transmembrane transport](http://purl.obolibrary.org/obo/GO_0034764) + + +### positive regulation of glycogen biosynthetic process `http://purl.obolibrary.org/obo/GO_0045725` +#### Removed +- [positive regulation of glycogen biosynthetic process](http://purl.obolibrary.org/obo/GO_0045725) SubClassOf [positive regulation of cellular biosynthetic process](http://purl.obolibrary.org/obo/GO_0031328) + + + +### positive regulation of histamine uptake `http://purl.obolibrary.org/obo/GO_0051618` + +#### Added +- [positive regulation of histamine uptake](http://purl.obolibrary.org/obo/GO_0051618) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that activates or increases the frequency, rate or extent of the directed movement of histamine into a cell." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:ai" + +- [positive regulation of histamine uptake](http://purl.obolibrary.org/obo/GO_0051618) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "upregulation of histamine uptake" + +- [positive regulation of histamine uptake](http://purl.obolibrary.org/obo/GO_0051618) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "up-regulation of histamine uptake" + +- [positive regulation of histamine uptake](http://purl.obolibrary.org/obo/GO_0051618) [label](http://www.w3.org/2000/01/rdf-schema#label) "positive regulation of histamine uptake" + +- [positive regulation of histamine uptake](http://purl.obolibrary.org/obo/GO_0051618) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0051618" + +- [positive regulation of histamine uptake](http://purl.obolibrary.org/obo/GO_0051618) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "stimulation of histamine uptake" + +- [positive regulation of histamine uptake](http://purl.obolibrary.org/obo/GO_0051618) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "activation of histamine uptake" + +- [positive regulation of histamine uptake](http://purl.obolibrary.org/obo/GO_0051618) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" + +- [positive regulation of histamine uptake](http://purl.obolibrary.org/obo/GO_0051618) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "positive regulation of histamine import" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dph" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:tb" + +- [positive regulation of histamine uptake](http://purl.obolibrary.org/obo/GO_0051618) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "up regulation of histamine uptake" + +- Class: [positive regulation of histamine uptake](http://purl.obolibrary.org/obo/GO_0051618) + +- [positive regulation of histamine uptake](http://purl.obolibrary.org/obo/GO_0051618) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([positively regulates](http://purl.obolibrary.org/obo/RO_0002213) some [histamine uptake](http://purl.obolibrary.org/obo/GO_0051615)) + +- [positive regulation of histamine uptake](http://purl.obolibrary.org/obo/GO_0051618) SubClassOf [regulation of histamine uptake](http://purl.obolibrary.org/obo/GO_0051616) + +- [positive regulation of histamine uptake](http://purl.obolibrary.org/obo/GO_0051618) SubClassOf [positively regulates](http://purl.obolibrary.org/obo/RO_0002213) some [histamine uptake](http://purl.obolibrary.org/obo/GO_0051615) + +- [positive regulation of histamine uptake](http://purl.obolibrary.org/obo/GO_0051618) SubClassOf [positive regulation of neurotransmitter uptake](http://purl.obolibrary.org/obo/GO_0051582) + + +### positive regulation of iron export across plasma membrane `http://purl.obolibrary.org/obo/GO_1904040` + +#### Added +- [positive regulation of iron export across plasma membrane](http://purl.obolibrary.org/obo/GO_1904040) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "positive regulation of ferrous iron export" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of iron export across plasma membrane](http://purl.obolibrary.org/obo/GO_1904040) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "upregulation of ferrous iron export" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of iron export across plasma membrane](http://purl.obolibrary.org/obo/GO_1904040) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "up-regulation of ferrous iron export" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of iron export across plasma membrane](http://purl.obolibrary.org/obo/GO_1904040) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2015-03-16T15:36:49Z" + +- [positive regulation of iron export across plasma membrane](http://purl.obolibrary.org/obo/GO_1904040) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "up-regulation of iron(2+) export" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of iron export across plasma membrane](http://purl.obolibrary.org/obo/GO_1904040) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that activates or increases the frequency, rate or extent of export of iron ions from inside of a cell, across the plasma membrane and into the extracellular region." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:15514116" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:kom" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:BHF" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GO_REF:0000058" + +- [positive regulation of iron export across plasma membrane](http://purl.obolibrary.org/obo/GO_1904040) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "up regulation of iron(2+) export" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of iron export across plasma membrane](http://purl.obolibrary.org/obo/GO_1904040) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" + +- [positive regulation of iron export across plasma membrane](http://purl.obolibrary.org/obo/GO_1904040) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:1904040" + +- [positive regulation of iron export across plasma membrane](http://purl.obolibrary.org/obo/GO_1904040) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "kom" + +- [positive regulation of iron export across plasma membrane](http://purl.obolibrary.org/obo/GO_1904040) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "positive regulation of iron(2+) export" + +- [positive regulation of iron export across plasma membrane](http://purl.obolibrary.org/obo/GO_1904040) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "activation of ferrous iron export" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of iron export across plasma membrane](http://purl.obolibrary.org/obo/GO_1904040) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "up regulation of ferrous iron export" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of iron export across plasma membrane](http://purl.obolibrary.org/obo/GO_1904040) [label](http://www.w3.org/2000/01/rdf-schema#label) "positive regulation of iron export across plasma membrane" + +- [positive regulation of iron export across plasma membrane](http://purl.obolibrary.org/obo/GO_1904040) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "activation of iron(2+) export" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of iron export across plasma membrane](http://purl.obolibrary.org/obo/GO_1904040) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "upregulation of iron(2+) export" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- Class: [positive regulation of iron export across plasma membrane](http://purl.obolibrary.org/obo/GO_1904040) + +- [positive regulation of iron export across plasma membrane](http://purl.obolibrary.org/obo/GO_1904040) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([positively regulates](http://purl.obolibrary.org/obo/RO_0002213) some [iron ion export across plasma membrane](http://purl.obolibrary.org/obo/GO_1903988)) + +- [positive regulation of iron export across plasma membrane](http://purl.obolibrary.org/obo/GO_1904040) SubClassOf [positive regulation of iron ion transmembrane transport](http://purl.obolibrary.org/obo/GO_0034761) + +- [positive regulation of iron export across plasma membrane](http://purl.obolibrary.org/obo/GO_1904040) SubClassOf [positively regulates](http://purl.obolibrary.org/obo/RO_0002213) some [iron ion export across plasma membrane](http://purl.obolibrary.org/obo/GO_1903988) + +- [positive regulation of iron export across plasma membrane](http://purl.obolibrary.org/obo/GO_1904040) SubClassOf [regulation of iron export across plasma membrane](http://purl.obolibrary.org/obo/GO_1904038) + + +### positive regulation of iron ion import across plasma membrane `http://purl.obolibrary.org/obo/GO_1904440` + +#### Added +- [positive regulation of iron ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_1904440) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "positive regulation of ferrous iron import across plasma membrane" + +- [positive regulation of iron ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_1904440) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "positive regulation of ferrous ion import into cell" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of iron ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_1904440) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2015-07-06T13:50:04Z" + +- [positive regulation of iron ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_1904440) [has_alternative_id](http://www.geneontology.org/formats/oboInOwl#hasAlternativeId) "GO:1903991" + +- [positive regulation of iron ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_1904440) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "activation of ferrous ion import into cell" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of iron ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_1904440) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that activates or increases the frequency, rate or extent of iron ions import across plasma membrane." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:kom" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:18353247" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:BHF" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GO_REF:0000058" + +- [positive regulation of iron ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_1904440) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "up-regulation of ferrous ion import into cell" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of iron ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_1904440) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "positive regulation of ferrous iron import into cell" + +- [positive regulation of iron ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_1904440) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "up regulation of ferrous iron import across plasma membrane" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of iron ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_1904440) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "upregulation of ferrous iron import across plasma membrane" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of iron ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_1904440) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "rl" + +- [positive regulation of iron ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_1904440) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "activation of ferrous iron import across plasma membrane" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of iron ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_1904440) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "up-regulation of ferrous iron import across plasma membrane" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of iron ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_1904440) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" + +- [positive regulation of iron ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_1904440) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "up regulation of ferrous ion import into cell" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of iron ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_1904440) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:1904440" + +- [positive regulation of iron ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_1904440) [label](http://www.w3.org/2000/01/rdf-schema#label) "positive regulation of iron ion import across plasma membrane" + +- [positive regulation of iron ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_1904440) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "upregulation of ferrous ion import into cell" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- Class: [positive regulation of iron ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_1904440) + +- [positive regulation of iron ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_1904440) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([positively regulates](http://purl.obolibrary.org/obo/RO_0002213) some [iron ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098711)) + +- [positive regulation of iron ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_1904440) SubClassOf [positive regulation of iron ion transmembrane transport](http://purl.obolibrary.org/obo/GO_0034761) + +- [positive regulation of iron ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_1904440) SubClassOf [regulation of iron ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_1904438) + +- [positive regulation of iron ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_1904440) SubClassOf [positively regulates](http://purl.obolibrary.org/obo/RO_0002213) some [iron ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098711) + + +### positive regulation of ligase activity `http://purl.obolibrary.org/obo/GO_0051351` +#### Removed +- [positive regulation of ligase activity](http://purl.obolibrary.org/obo/GO_0051351) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that activates or increases the frequency, rate or extent of ligase activity, the catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:ai" + +- [positive regulation of ligase activity](http://purl.obolibrary.org/obo/GO_0051351) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "activation of ligase activity" + +- [positive regulation of ligase activity](http://purl.obolibrary.org/obo/GO_0051351) [label](http://www.w3.org/2000/01/rdf-schema#label) "positive regulation of ligase activity" + +- [positive regulation of ligase activity](http://purl.obolibrary.org/obo/GO_0051351) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "upregulation of ligase activity" + +- [positive regulation of ligase activity](http://purl.obolibrary.org/obo/GO_0051351) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "up-regulation of ligase activity" + +- [positive regulation of ligase activity](http://purl.obolibrary.org/obo/GO_0051351) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "up regulation of ligase activity" + +- [positive regulation of ligase activity](http://purl.obolibrary.org/obo/GO_0051351) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "stimulation of ligase activity" + +- [positive regulation of ligase activity](http://purl.obolibrary.org/obo/GO_0051351) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0051351" + +- [positive regulation of ligase activity](http://purl.obolibrary.org/obo/GO_0051351) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate) + +- [positive regulation of ligase activity](http://purl.obolibrary.org/obo/GO_0051351) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "ligase activator" + +- [positive regulation of ligase activity](http://purl.obolibrary.org/obo/GO_0051351) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" + +- Class: [positive regulation of ligase activity](http://purl.obolibrary.org/obo/GO_0051351) + +- [positive regulation of ligase activity](http://purl.obolibrary.org/obo/GO_0051351) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([positively regulates](http://purl.obolibrary.org/obo/RO_0002213) some [ligase activity](http://purl.obolibrary.org/obo/GO_0016874)) + +- [positive regulation of ligase activity](http://purl.obolibrary.org/obo/GO_0051351) SubClassOf [positively regulates](http://purl.obolibrary.org/obo/RO_0002213) some [ligase activity](http://purl.obolibrary.org/obo/GO_0016874) + +- [positive regulation of ligase activity](http://purl.obolibrary.org/obo/GO_0051351) SubClassOf [positive regulation of catalytic activity](http://purl.obolibrary.org/obo/GO_0043085) + +- [positive regulation of ligase activity](http://purl.obolibrary.org/obo/GO_0051351) SubClassOf [regulation of ligase activity](http://purl.obolibrary.org/obo/GO_0051340) + + + +### positive regulation of macroautophagy `http://purl.obolibrary.org/obo/GO_0016239` +#### Removed +- [positive regulation of macroautophagy](http://purl.obolibrary.org/obo/GO_0016239) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "activation of macroautophagy" + +- [positive regulation of macroautophagy](http://purl.obolibrary.org/obo/GO_0016239) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "upregulation of macroautophagy" + +- [positive regulation of macroautophagy](http://purl.obolibrary.org/obo/GO_0016239) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "up regulation of macroautophagy" + +- [positive regulation of macroautophagy](http://purl.obolibrary.org/obo/GO_0016239) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process, such as recognition of nutrient depletion, that activates or increases the rate of macroautophagy to bring cytosolic macromolecules to the vacuole/lysosome for degradation." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:9412464" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:go_curators" + +- [positive regulation of macroautophagy](http://purl.obolibrary.org/obo/GO_0016239) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0016239" + +- [positive regulation of macroautophagy](http://purl.obolibrary.org/obo/GO_0016239) [label](http://www.w3.org/2000/01/rdf-schema#label) "positive regulation of macroautophagy" + +- [positive regulation of macroautophagy](http://purl.obolibrary.org/obo/GO_0016239) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "stimulation of macroautophagy" + +- [positive regulation of macroautophagy](http://purl.obolibrary.org/obo/GO_0016239) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "up-regulation of macroautophagy" + +- [positive regulation of macroautophagy](http://purl.obolibrary.org/obo/GO_0016239) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "positive regulation of starvation-induced autophagy" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dph" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:ascb_2009" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:tb" + +- [positive regulation of macroautophagy](http://purl.obolibrary.org/obo/GO_0016239) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" + +- Class: [positive regulation of macroautophagy](http://purl.obolibrary.org/obo/GO_0016239) + +- [positive regulation of macroautophagy](http://purl.obolibrary.org/obo/GO_0016239) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([positively regulates](http://purl.obolibrary.org/obo/RO_0002213) some [macroautophagy](http://purl.obolibrary.org/obo/GO_0016236)) + +- [positive regulation of macroautophagy](http://purl.obolibrary.org/obo/GO_0016239) SubClassOf [positive regulation of autophagy](http://purl.obolibrary.org/obo/GO_0010508) + +- [positive regulation of macroautophagy](http://purl.obolibrary.org/obo/GO_0016239) SubClassOf [positively regulates](http://purl.obolibrary.org/obo/RO_0002213) some [macroautophagy](http://purl.obolibrary.org/obo/GO_0016236) + +- [positive regulation of macroautophagy](http://purl.obolibrary.org/obo/GO_0016239) SubClassOf [regulation of macroautophagy](http://purl.obolibrary.org/obo/GO_0016241) + + + +### positive regulation of macromolecule biosynthetic process `http://purl.obolibrary.org/obo/GO_0010557` +#### Removed +- [positive regulation of macromolecule biosynthetic process](http://purl.obolibrary.org/obo/GO_0010557) SubClassOf [positive regulation of biosynthetic process](http://purl.obolibrary.org/obo/GO_0009891) + +#### Added +- [positive regulation of macromolecule biosynthetic process](http://purl.obolibrary.org/obo/GO_0010557) SubClassOf [positive regulation of cellular biosynthetic process](http://purl.obolibrary.org/obo/GO_0031328) + + +### positive regulation of neuron apoptotic process `http://purl.obolibrary.org/obo/GO_0043525` +#### Removed +- [positive regulation of neuron apoptotic process](http://purl.obolibrary.org/obo/GO_0043525) SubClassOf [positive regulation of neuron death](http://purl.obolibrary.org/obo/GO_1901216) + + + +### positive regulation of neuron death `http://purl.obolibrary.org/obo/GO_1901216` +#### Removed +- [positive regulation of neuron death](http://purl.obolibrary.org/obo/GO_1901216) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "up regulation of neuron cell death" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of neuron death](http://purl.obolibrary.org/obo/GO_1901216) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" + +- [positive regulation of neuron death](http://purl.obolibrary.org/obo/GO_1901216) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "positive regulation of neuron cell death" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of neuron death](http://purl.obolibrary.org/obo/GO_1901216) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that activates or increases the frequency, rate or extent of neuron death." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:rph" + +- [positive regulation of neuron death](http://purl.obolibrary.org/obo/GO_1901216) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "rph" + +- [positive regulation of neuron death](http://purl.obolibrary.org/obo/GO_1901216) [label](http://www.w3.org/2000/01/rdf-schema#label) "positive regulation of neuron death" + +- [positive regulation of neuron death](http://purl.obolibrary.org/obo/GO_1901216) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "up-regulation of neuronal cell death" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of neuron death](http://purl.obolibrary.org/obo/GO_1901216) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "positive regulation of neuronal cell death" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of neuron death](http://purl.obolibrary.org/obo/GO_1901216) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "upregulation of neuronal cell death" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of neuron death](http://purl.obolibrary.org/obo/GO_1901216) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "activation of neuron death" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of neuron death](http://purl.obolibrary.org/obo/GO_1901216) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2012-08-02T09:58:15Z" + +- [positive regulation of neuron death](http://purl.obolibrary.org/obo/GO_1901216) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:1901216" + +- [positive regulation of neuron death](http://purl.obolibrary.org/obo/GO_1901216) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "activation of neuronal cell death" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of neuron death](http://purl.obolibrary.org/obo/GO_1901216) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "up-regulation of neuron cell death" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of neuron death](http://purl.obolibrary.org/obo/GO_1901216) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "up regulation of neuronal cell death" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of neuron death](http://purl.obolibrary.org/obo/GO_1901216) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "up-regulation of neuron death" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of neuron death](http://purl.obolibrary.org/obo/GO_1901216) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "up regulation of neuron death" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of neuron death](http://purl.obolibrary.org/obo/GO_1901216) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "activation of neuron cell death" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of neuron death](http://purl.obolibrary.org/obo/GO_1901216) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "upregulation of neuron cell death" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of neuron death](http://purl.obolibrary.org/obo/GO_1901216) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "upregulation of neuron death" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- Class: [positive regulation of neuron death](http://purl.obolibrary.org/obo/GO_1901216) + +- [positive regulation of neuron death](http://purl.obolibrary.org/obo/GO_1901216) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([positively regulates](http://purl.obolibrary.org/obo/RO_0002213) some [neuron death](http://purl.obolibrary.org/obo/GO_0070997)) + +- [positive regulation of neuron death](http://purl.obolibrary.org/obo/GO_1901216) SubClassOf [positive regulation of cellular process](http://purl.obolibrary.org/obo/GO_0048522) + +- [positive regulation of neuron death](http://purl.obolibrary.org/obo/GO_1901216) SubClassOf [positively regulates](http://purl.obolibrary.org/obo/RO_0002213) some [neuron death](http://purl.obolibrary.org/obo/GO_0070997) + +- [positive regulation of neuron death](http://purl.obolibrary.org/obo/GO_1901216) SubClassOf [regulation of neuron death](http://purl.obolibrary.org/obo/GO_1901214) + + + +### positive regulation of neurotransmitter uptake `http://purl.obolibrary.org/obo/GO_0051582` + +#### Added +- [positive regulation of neurotransmitter uptake](http://purl.obolibrary.org/obo/GO_0051582) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "stimulation of neurotransmitter uptake" + +- [positive regulation of neurotransmitter uptake](http://purl.obolibrary.org/obo/GO_0051582) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "up regulation of neurotransmitter uptake" + +- [positive regulation of neurotransmitter uptake](http://purl.obolibrary.org/obo/GO_0051582) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "positive regulation of neurotransmitter import" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dph" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:tb" + +- [positive regulation of neurotransmitter uptake](http://purl.obolibrary.org/obo/GO_0051582) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" + +- [positive regulation of neurotransmitter uptake](http://purl.obolibrary.org/obo/GO_0051582) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "activation of neurotransmitter uptake" + +- [positive regulation of neurotransmitter uptake](http://purl.obolibrary.org/obo/GO_0051582) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "upregulation of neurotransmitter uptake" + +- [positive regulation of neurotransmitter uptake](http://purl.obolibrary.org/obo/GO_0051582) [label](http://www.w3.org/2000/01/rdf-schema#label) "positive regulation of neurotransmitter uptake" + +- [positive regulation of neurotransmitter uptake](http://purl.obolibrary.org/obo/GO_0051582) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that activates or increases the frequency, rate or extent of the directed movement of a neurotransmitter into a neuron or glial cell." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:ai" + +- [positive regulation of neurotransmitter uptake](http://purl.obolibrary.org/obo/GO_0051582) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0051582" + +- [positive regulation of neurotransmitter uptake](http://purl.obolibrary.org/obo/GO_0051582) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "up-regulation of neurotransmitter uptake" + +- Class: [positive regulation of neurotransmitter uptake](http://purl.obolibrary.org/obo/GO_0051582) + +- [positive regulation of neurotransmitter uptake](http://purl.obolibrary.org/obo/GO_0051582) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([positively regulates](http://purl.obolibrary.org/obo/RO_0002213) some [neurotransmitter uptake](http://purl.obolibrary.org/obo/GO_0001504)) + +- [positive regulation of neurotransmitter uptake](http://purl.obolibrary.org/obo/GO_0051582) SubClassOf [positive regulation of neurotransmitter transport](http://purl.obolibrary.org/obo/GO_0051590) + +- [positive regulation of neurotransmitter uptake](http://purl.obolibrary.org/obo/GO_0051582) SubClassOf [positively regulates](http://purl.obolibrary.org/obo/RO_0002213) some [neurotransmitter uptake](http://purl.obolibrary.org/obo/GO_0001504) + +- [positive regulation of neurotransmitter uptake](http://purl.obolibrary.org/obo/GO_0051582) SubClassOf [regulation of neurotransmitter uptake](http://purl.obolibrary.org/obo/GO_0051580) + + +### positive regulation of nucleocytoplasmic transport `http://purl.obolibrary.org/obo/GO_0046824` + +#### Added +- [positive regulation of nucleocytoplasmic transport](http://purl.obolibrary.org/obo/GO_0046824) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that activates or increases the frequency, rate or extent of the directed movement of substances between the nucleus and the cytoplasm." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:bf" + +- [positive regulation of nucleocytoplasmic transport](http://purl.obolibrary.org/obo/GO_0046824) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "up regulation of nucleocytoplasmic transport" + +- [positive regulation of nucleocytoplasmic transport](http://purl.obolibrary.org/obo/GO_0046824) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "stimulation of nucleocytoplasmic transport" + +- [positive regulation of nucleocytoplasmic transport](http://purl.obolibrary.org/obo/GO_0046824) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0046824" + +- [positive regulation of nucleocytoplasmic transport](http://purl.obolibrary.org/obo/GO_0046824) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "up-regulation of nucleocytoplasmic transport" + +- [positive regulation of nucleocytoplasmic transport](http://purl.obolibrary.org/obo/GO_0046824) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "activation of nucleocytoplasmic transport" + +- [positive regulation of nucleocytoplasmic transport](http://purl.obolibrary.org/obo/GO_0046824) [label](http://www.w3.org/2000/01/rdf-schema#label) "positive regulation of nucleocytoplasmic transport" + +- [positive regulation of nucleocytoplasmic transport](http://purl.obolibrary.org/obo/GO_0046824) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" + +- [positive regulation of nucleocytoplasmic transport](http://purl.obolibrary.org/obo/GO_0046824) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "upregulation of nucleocytoplasmic transport" + +- Class: [positive regulation of nucleocytoplasmic transport](http://purl.obolibrary.org/obo/GO_0046824) + +- [positive regulation of nucleocytoplasmic transport](http://purl.obolibrary.org/obo/GO_0046824) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([positively regulates](http://purl.obolibrary.org/obo/RO_0002213) some [nucleocytoplasmic transport](http://purl.obolibrary.org/obo/GO_0006913)) + +- [positive regulation of nucleocytoplasmic transport](http://purl.obolibrary.org/obo/GO_0046824) SubClassOf [positive regulation of intracellular transport](http://purl.obolibrary.org/obo/GO_0032388) + +- [positive regulation of nucleocytoplasmic transport](http://purl.obolibrary.org/obo/GO_0046824) SubClassOf [positively regulates](http://purl.obolibrary.org/obo/RO_0002213) some [nucleocytoplasmic transport](http://purl.obolibrary.org/obo/GO_0006913) + +- [positive regulation of nucleocytoplasmic transport](http://purl.obolibrary.org/obo/GO_0046824) SubClassOf [regulation of nucleocytoplasmic transport](http://purl.obolibrary.org/obo/GO_0046822) + + +### positive regulation of protein export from nucleus `http://purl.obolibrary.org/obo/GO_0046827` + +#### Added +- [positive regulation of protein export from nucleus](http://purl.obolibrary.org/obo/GO_0046827) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "up-regulation of protein export from nucleus" + +- [positive regulation of protein export from nucleus](http://purl.obolibrary.org/obo/GO_0046827) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "positive regulation of protein-nucleus export" + +- [positive regulation of protein export from nucleus](http://purl.obolibrary.org/obo/GO_0046827) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "stimulation of protein export from nucleus" + +- [positive regulation of protein export from nucleus](http://purl.obolibrary.org/obo/GO_0046827) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" + +- [positive regulation of protein export from nucleus](http://purl.obolibrary.org/obo/GO_0046827) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "positive regulation of protein export out of nucleus" + +- [positive regulation of protein export from nucleus](http://purl.obolibrary.org/obo/GO_0046827) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "up regulation of protein export from nucleus" + +- [positive regulation of protein export from nucleus](http://purl.obolibrary.org/obo/GO_0046827) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "positive regulation of protein transport from nucleus to cytoplasm" + +- [positive regulation of protein export from nucleus](http://purl.obolibrary.org/obo/GO_0046827) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "positive regulation of protein export from cell nucleus" + +- [positive regulation of protein export from nucleus](http://purl.obolibrary.org/obo/GO_0046827) [label](http://www.w3.org/2000/01/rdf-schema#label) "positive regulation of protein export from nucleus" + +- [positive regulation of protein export from nucleus](http://purl.obolibrary.org/obo/GO_0046827) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0046827" + +- [positive regulation of protein export from nucleus](http://purl.obolibrary.org/obo/GO_0046827) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "activation of protein export from nucleus" + +- [positive regulation of protein export from nucleus](http://purl.obolibrary.org/obo/GO_0046827) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that activates or increases the frequency, rate or extent of directed movement of proteins from the nucleus into the cytoplasm." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:bf" + +- [positive regulation of protein export from nucleus](http://purl.obolibrary.org/obo/GO_0046827) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "upregulation of protein export from nucleus" + +- Class: [positive regulation of protein export from nucleus](http://purl.obolibrary.org/obo/GO_0046827) + +- [positive regulation of protein export from nucleus](http://purl.obolibrary.org/obo/GO_0046827) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([positively regulates](http://purl.obolibrary.org/obo/RO_0002213) some [protein export from nucleus](http://purl.obolibrary.org/obo/GO_0006611)) + +- [positive regulation of protein export from nucleus](http://purl.obolibrary.org/obo/GO_0046827) SubClassOf [positive regulation of intracellular protein transport](http://purl.obolibrary.org/obo/GO_0090316) + +- [positive regulation of protein export from nucleus](http://purl.obolibrary.org/obo/GO_0046827) SubClassOf [positive regulation of nucleocytoplasmic transport](http://purl.obolibrary.org/obo/GO_0046824) + +- [positive regulation of protein export from nucleus](http://purl.obolibrary.org/obo/GO_0046827) SubClassOf [positively regulates](http://purl.obolibrary.org/obo/RO_0002213) some [protein export from nucleus](http://purl.obolibrary.org/obo/GO_0006611) + +- [positive regulation of protein export from nucleus](http://purl.obolibrary.org/obo/GO_0046827) SubClassOf [regulation of protein export from nucleus](http://purl.obolibrary.org/obo/GO_0046825) + + +### positive regulation of protein import into nucleus `http://purl.obolibrary.org/obo/GO_0042307` + +#### Added +- [positive regulation of protein import into nucleus](http://purl.obolibrary.org/obo/GO_0042307) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0042307" + +- [positive regulation of protein import into nucleus](http://purl.obolibrary.org/obo/GO_0042307) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "positive regulation of protein transport from cytoplasm to nucleus" + +- [positive regulation of protein import into nucleus](http://purl.obolibrary.org/obo/GO_0042307) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that activates or increases the frequency, rate or extent of movement of proteins from the cytoplasm into the nucleus." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:jl" + +- [positive regulation of protein import into nucleus](http://purl.obolibrary.org/obo/GO_0042307) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "activation of protein import into nucleus" + +- [positive regulation of protein import into nucleus](http://purl.obolibrary.org/obo/GO_0042307) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "stimulation of protein import into nucleus" + +- [positive regulation of protein import into nucleus](http://purl.obolibrary.org/obo/GO_0042307) [label](http://www.w3.org/2000/01/rdf-schema#label) "positive regulation of protein import into nucleus" + +- [positive regulation of protein import into nucleus](http://purl.obolibrary.org/obo/GO_0042307) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "upregulation of protein import into nucleus" + +- [positive regulation of protein import into nucleus](http://purl.obolibrary.org/obo/GO_0042307) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "positive regulation of protein-nucleus import" + +- [positive regulation of protein import into nucleus](http://purl.obolibrary.org/obo/GO_0042307) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" + +- [positive regulation of protein import into nucleus](http://purl.obolibrary.org/obo/GO_0042307) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "up-regulation of protein import into nucleus" + +- [positive regulation of protein import into nucleus](http://purl.obolibrary.org/obo/GO_0042307) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "up regulation of protein import into nucleus" + +- [positive regulation of protein import into nucleus](http://purl.obolibrary.org/obo/GO_0042307) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "positive regulation of protein import into cell nucleus" + +- Class: [positive regulation of protein import into nucleus](http://purl.obolibrary.org/obo/GO_0042307) + +- [positive regulation of protein import into nucleus](http://purl.obolibrary.org/obo/GO_0042307) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([positively regulates](http://purl.obolibrary.org/obo/RO_0002213) some [protein import into nucleus](http://purl.obolibrary.org/obo/GO_0006606)) + +- [positive regulation of protein import into nucleus](http://purl.obolibrary.org/obo/GO_0042307) SubClassOf [positive regulation of intracellular protein transport](http://purl.obolibrary.org/obo/GO_0090316) + +- [positive regulation of protein import into nucleus](http://purl.obolibrary.org/obo/GO_0042307) SubClassOf [positive regulation of nucleocytoplasmic transport](http://purl.obolibrary.org/obo/GO_0046824) + +- [positive regulation of protein import into nucleus](http://purl.obolibrary.org/obo/GO_0042307) SubClassOf [positive regulation of protein localization to nucleus](http://purl.obolibrary.org/obo/GO_1900182) + +- [positive regulation of protein import into nucleus](http://purl.obolibrary.org/obo/GO_0042307) SubClassOf [positively regulates](http://purl.obolibrary.org/obo/RO_0002213) some [protein import into nucleus](http://purl.obolibrary.org/obo/GO_0006606) + +- [positive regulation of protein import into nucleus](http://purl.obolibrary.org/obo/GO_0042307) SubClassOf [regulation of protein import into nucleus](http://purl.obolibrary.org/obo/GO_0042306) + + +### positive regulation of protein serine/threonine kinase activity `http://purl.obolibrary.org/obo/GO_0071902` +#### Removed +- [positive regulation of protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0071902) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0071902" + +- [positive regulation of protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0071902) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" + +- [positive regulation of protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0071902) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate) + +- [positive regulation of protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0071902) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that increases the rate, frequency, or extent of protein serine/threonine kinase activity." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:mah" + +- [positive regulation of protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0071902) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "mah" + +- [positive regulation of protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0071902) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2010-09-15T03:09:57Z" + +- [positive regulation of protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0071902) [label](http://www.w3.org/2000/01/rdf-schema#label) "positive regulation of protein serine/threonine kinase activity" + +- Class: [positive regulation of protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0071902) + +- [positive regulation of protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0071902) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([positively regulates](http://purl.obolibrary.org/obo/RO_0002213) some [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674)) + +- [positive regulation of protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0071902) SubClassOf [positively regulates](http://purl.obolibrary.org/obo/RO_0002213) some [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) + +- [positive regulation of protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0071902) SubClassOf [regulation of protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0071900) + +- [positive regulation of protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0071902) SubClassOf [positive regulation of protein kinase activity](http://purl.obolibrary.org/obo/GO_0045860) + + + +### positive regulation of release of sequestered calcium ion into cytosol `http://purl.obolibrary.org/obo/GO_0051281` + +#### Added +- [positive regulation of release of sequestered calcium ion into cytosol](http://purl.obolibrary.org/obo/GO_0051281) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "positive regulation of release of sequestered calcium ion into cytoplasm" + +- [positive regulation of release of sequestered calcium ion into cytosol](http://purl.obolibrary.org/obo/GO_0051281) [label](http://www.w3.org/2000/01/rdf-schema#label) "positive regulation of release of sequestered calcium ion into cytosol" + +- [positive regulation of release of sequestered calcium ion into cytosol](http://purl.obolibrary.org/obo/GO_0051281) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "positive regulation of cytosolic release of sequestered calcium ion (Ca2+)" + +- [positive regulation of release of sequestered calcium ion into cytosol](http://purl.obolibrary.org/obo/GO_0051281) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" + +- [positive regulation of release of sequestered calcium ion into cytosol](http://purl.obolibrary.org/obo/GO_0051281) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "upregulation of release of sequestered calcium ion into cytosol" + +- [positive regulation of release of sequestered calcium ion into cytosol](http://purl.obolibrary.org/obo/GO_0051281) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "activation of release of sequestered calcium ion into cytosol" + +- [positive regulation of release of sequestered calcium ion into cytosol](http://purl.obolibrary.org/obo/GO_0051281) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "positive regulation of release of stored calcium ion (Ca2+) into cytoplasm" + +- [positive regulation of release of sequestered calcium ion into cytosol](http://purl.obolibrary.org/obo/GO_0051281) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that activates or increases the frequency, rate or extent of the release into the cytosolic compartment of calcium ions sequestered in the endoplasmic reticulum or mitochondria." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:ai" + +- [positive regulation of release of sequestered calcium ion into cytosol](http://purl.obolibrary.org/obo/GO_0051281) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "positive regulation of cytoplasmic release of sequestered calcium ion (Ca2+)" + +- [positive regulation of release of sequestered calcium ion into cytosol](http://purl.obolibrary.org/obo/GO_0051281) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "positive regulation of cytoplasmic release of stored calcium ion (Ca2+)" + +- [positive regulation of release of sequestered calcium ion into cytosol](http://purl.obolibrary.org/obo/GO_0051281) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "up-regulation of release of sequestered calcium ion into cytosol" + +- [positive regulation of release of sequestered calcium ion into cytosol](http://purl.obolibrary.org/obo/GO_0051281) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "stimulation of release of sequestered calcium ion into cytosol" + +- [positive regulation of release of sequestered calcium ion into cytosol](http://purl.obolibrary.org/obo/GO_0051281) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "positive regulation of release of stored calcium ion (Ca2+) into cytosol" + +- [positive regulation of release of sequestered calcium ion into cytosol](http://purl.obolibrary.org/obo/GO_0051281) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "positive regulation of release of sequestered calcium ion (Ca2+)" + +- [positive regulation of release of sequestered calcium ion into cytosol](http://purl.obolibrary.org/obo/GO_0051281) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "positive regulation of calcium mobilization" + +- [positive regulation of release of sequestered calcium ion into cytosol](http://purl.obolibrary.org/obo/GO_0051281) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "positive regulation of release of stored calcium ion (Ca2+)" + +- [positive regulation of release of sequestered calcium ion into cytosol](http://purl.obolibrary.org/obo/GO_0051281) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0051281" + +- [positive regulation of release of sequestered calcium ion into cytosol](http://purl.obolibrary.org/obo/GO_0051281) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "positive regulation of cytosolic release of stored calcium ion (Ca2+)" + +- [positive regulation of release of sequestered calcium ion into cytosol](http://purl.obolibrary.org/obo/GO_0051281) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "positive regulation of calcium ion (Ca2+) mobilization" + +- [positive regulation of release of sequestered calcium ion into cytosol](http://purl.obolibrary.org/obo/GO_0051281) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "up regulation of release of sequestered calcium ion into cytosol" + +- Class: [positive regulation of release of sequestered calcium ion into cytosol](http://purl.obolibrary.org/obo/GO_0051281) + +- [positive regulation of release of sequestered calcium ion into cytosol](http://purl.obolibrary.org/obo/GO_0051281) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([positively regulates](http://purl.obolibrary.org/obo/RO_0002213) some [release of sequestered calcium ion into cytosol](http://purl.obolibrary.org/obo/GO_0051209)) + +- [positive regulation of release of sequestered calcium ion into cytosol](http://purl.obolibrary.org/obo/GO_0051281) SubClassOf [regulation of release of sequestered calcium ion into cytosol](http://purl.obolibrary.org/obo/GO_0051279) + +- [positive regulation of release of sequestered calcium ion into cytosol](http://purl.obolibrary.org/obo/GO_0051281) SubClassOf [positive regulation of calcium ion transmembrane transport](http://purl.obolibrary.org/obo/GO_1904427) + +- [positive regulation of release of sequestered calcium ion into cytosol](http://purl.obolibrary.org/obo/GO_0051281) SubClassOf [positively regulates](http://purl.obolibrary.org/obo/RO_0002213) some [release of sequestered calcium ion into cytosol](http://purl.obolibrary.org/obo/GO_0051209) + + +### positive regulation of retrograde dense core granule transport `http://purl.obolibrary.org/obo/GO_1901956` + +#### Added +- [positive regulation of retrograde dense core granule transport](http://purl.obolibrary.org/obo/GO_1901956) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "pr" + +- [positive regulation of retrograde dense core granule transport](http://purl.obolibrary.org/obo/GO_1901956) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "activation of retrograde dense core granule transport" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of retrograde dense core granule transport](http://purl.obolibrary.org/obo/GO_1901956) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "upregulation of retrograde dense core granule transport" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of retrograde dense core granule transport](http://purl.obolibrary.org/obo/GO_1901956) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "up-regulation of retrograde dense core granule transport" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of retrograde dense core granule transport](http://purl.obolibrary.org/obo/GO_1901956) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that activates or increases the frequency, rate or extent of retrograde dense core granule transport." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:23358451" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:kmv" + +- [positive regulation of retrograde dense core granule transport](http://purl.obolibrary.org/obo/GO_1901956) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "up regulation of retrograde dense core granule transport" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + +- [positive regulation of retrograde dense core granule transport](http://purl.obolibrary.org/obo/GO_1901956) [label](http://www.w3.org/2000/01/rdf-schema#label) "positive regulation of retrograde dense core granule transport" + +- [positive regulation of retrograde dense core granule transport](http://purl.obolibrary.org/obo/GO_1901956) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2013-02-19T13:36:52Z" + +- [positive regulation of retrograde dense core granule transport](http://purl.obolibrary.org/obo/GO_1901956) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" + +- [positive regulation of retrograde dense core granule transport](http://purl.obolibrary.org/obo/GO_1901956) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:1901956" + +- Class: [positive regulation of retrograde dense core granule transport](http://purl.obolibrary.org/obo/GO_1901956) + +- [positive regulation of retrograde dense core granule transport](http://purl.obolibrary.org/obo/GO_1901956) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([positively regulates](http://purl.obolibrary.org/obo/RO_0002213) some [retrograde neuronal dense core vesicle transport](http://purl.obolibrary.org/obo/GO_1990049)) + +- [positive regulation of retrograde dense core granule transport](http://purl.obolibrary.org/obo/GO_1901956) SubClassOf [positive regulation of vesicle transport along microtubule](http://purl.obolibrary.org/obo/GO_1901610) + +- [positive regulation of retrograde dense core granule transport](http://purl.obolibrary.org/obo/GO_1901956) SubClassOf [regulation of retrograde dense core granule transport](http://purl.obolibrary.org/obo/GO_1901954) + +- [positive regulation of retrograde dense core granule transport](http://purl.obolibrary.org/obo/GO_1901956) SubClassOf [positive regulation of retrograde axon cargo transport](http://purl.obolibrary.org/obo/GO_2001019) + +- [positive regulation of retrograde dense core granule transport](http://purl.obolibrary.org/obo/GO_1901956) SubClassOf [positive regulation of dense core granule transport](http://purl.obolibrary.org/obo/GO_1904811) + +- [positive regulation of retrograde dense core granule transport](http://purl.obolibrary.org/obo/GO_1901956) SubClassOf [positively regulates](http://purl.obolibrary.org/obo/RO_0002213) some [retrograde neuronal dense core vesicle transport](http://purl.obolibrary.org/obo/GO_1990049) + + +### positive regulation of sequestering of calcium ion `http://purl.obolibrary.org/obo/GO_0051284` + +#### Added +- [positive regulation of sequestering of calcium ion](http://purl.obolibrary.org/obo/GO_0051284) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "positive regulation of sequestration of calcium ion (Ca2+)" + +- [positive regulation of sequestering of calcium ion](http://purl.obolibrary.org/obo/GO_0051284) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "positive regulation of sequestering of calcium ion (Ca2+)" + +- [positive regulation of sequestering of calcium ion](http://purl.obolibrary.org/obo/GO_0051284) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "up-regulation of sequestering of calcium ion" + +- [positive regulation of sequestering of calcium ion](http://purl.obolibrary.org/obo/GO_0051284) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0051284" + +- [positive regulation of sequestering of calcium ion](http://purl.obolibrary.org/obo/GO_0051284) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "positive regulation of storage of calcium ion (Ca2+)" + +- [positive regulation of sequestering of calcium ion](http://purl.obolibrary.org/obo/GO_0051284) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "positive regulation of calcium ion (Ca2+) sequestering" + +- [positive regulation of sequestering of calcium ion](http://purl.obolibrary.org/obo/GO_0051284) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "positive regulation of calcium ion (Ca2+) retention" + +- [positive regulation of sequestering of calcium ion](http://purl.obolibrary.org/obo/GO_0051284) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "activation of sequestering of calcium ion" + +- [positive regulation of sequestering of calcium ion](http://purl.obolibrary.org/obo/GO_0051284) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "positive regulation of calcium ion (Ca2+) sequestration" + +- [positive regulation of sequestering of calcium ion](http://purl.obolibrary.org/obo/GO_0051284) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "positive regulation of retention of calcium ion (Ca2+)" + +- [positive regulation of sequestering of calcium ion](http://purl.obolibrary.org/obo/GO_0051284) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "up regulation of sequestering of calcium ion" + +- [positive regulation of sequestering of calcium ion](http://purl.obolibrary.org/obo/GO_0051284) [label](http://www.w3.org/2000/01/rdf-schema#label) "positive regulation of sequestering of calcium ion" + +- [positive regulation of sequestering of calcium ion](http://purl.obolibrary.org/obo/GO_0051284) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" + +- [positive regulation of sequestering of calcium ion](http://purl.obolibrary.org/obo/GO_0051284) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "positive regulation of calcium ion (Ca2+) storage" + +- [positive regulation of sequestering of calcium ion](http://purl.obolibrary.org/obo/GO_0051284) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "stimulation of sequestering of calcium ion" + +- [positive regulation of sequestering of calcium ion](http://purl.obolibrary.org/obo/GO_0051284) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "upregulation of sequestering of calcium ion" + +- [positive regulation of sequestering of calcium ion](http://purl.obolibrary.org/obo/GO_0051284) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that activates or increases the frequency, rate or extent of the binding or confining calcium ions such that they are separated from other components of a biological system." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:ai" + +- Class: [positive regulation of sequestering of calcium ion](http://purl.obolibrary.org/obo/GO_0051284) + +- [positive regulation of sequestering of calcium ion](http://purl.obolibrary.org/obo/GO_0051284) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([positively regulates](http://purl.obolibrary.org/obo/RO_0002213) some [sequestering of calcium ion](http://purl.obolibrary.org/obo/GO_0051208)) + +- [positive regulation of sequestering of calcium ion](http://purl.obolibrary.org/obo/GO_0051284) SubClassOf [positive regulation of cellular process](http://purl.obolibrary.org/obo/GO_0048522) + +- [positive regulation of sequestering of calcium ion](http://purl.obolibrary.org/obo/GO_0051284) SubClassOf [positively regulates](http://purl.obolibrary.org/obo/RO_0002213) some [sequestering of calcium ion](http://purl.obolibrary.org/obo/GO_0051208) + +- [positive regulation of sequestering of calcium ion](http://purl.obolibrary.org/obo/GO_0051284) SubClassOf [regulation of sequestering of calcium ion](http://purl.obolibrary.org/obo/GO_0051282) + + +### positive regulation of translation `http://purl.obolibrary.org/obo/GO_0045727` +#### Removed +- [positive regulation of translation](http://purl.obolibrary.org/obo/GO_0045727) SubClassOf [positive regulation of macromolecule biosynthetic process](http://purl.obolibrary.org/obo/GO_0010557) + + + +### positive regulation of translational initiation `http://purl.obolibrary.org/obo/GO_0045948` +#### Removed +- [positive regulation of translational initiation](http://purl.obolibrary.org/obo/GO_0045948) SubClassOf [positive regulation of cellular metabolic process](http://purl.obolibrary.org/obo/GO_0031325) + + + +### positively correlated with `http://purl.obolibrary.org/obo/RO_0017003` +#### Removed +- [positively correlated with](http://purl.obolibrary.org/obo/RO_0017003) [IAO_0000118](http://purl.obolibrary.org/obo/IAO_0000118) "directly correlated with"@en + +- [positively correlated with](http://purl.obolibrary.org/obo/RO_0017003) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A relation between entities in which one increases or decreases as the other does the same."@en + +- [positively correlated with](http://purl.obolibrary.org/obo/RO_0017003) [contributor](http://purl.org/dc/terms/contributor) [0000-0003-1909-9269](https://orcid.org/0000-0003-1909-9269) + +- [positively correlated with](http://purl.obolibrary.org/obo/RO_0017003) [label](http://www.w3.org/2000/01/rdf-schema#label) "positively correlated with"@en + +- ObjectProperty: [positively correlated with](http://purl.obolibrary.org/obo/RO_0017003) + +- Reflexive: [positively correlated with](http://purl.obolibrary.org/obo/RO_0017003) + +- [positively correlated with](http://purl.obolibrary.org/obo/RO_0017003) SubPropertyOf: [correlated with](http://purl.obolibrary.org/obo/RO_0002610) + +- Symmetric: [positively correlated with](http://purl.obolibrary.org/obo/RO_0017003) + + + +### posterior lateral line nerve glial cell morphogenesis involved in differentiation `http://purl.obolibrary.org/obo/GO_0048942` +#### Removed +- [posterior lateral line nerve glial cell morphogenesis involved in differentiation](http://purl.obolibrary.org/obo/GO_0048942) EquivalentTo [cell morphogenesis involved in differentiation](http://purl.obolibrary.org/obo/GO_0000904) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [posterior lateral line nerve glial cell development](http://purl.obolibrary.org/obo/GO_0048941)) + +#### Added +- [posterior lateral line nerve glial cell morphogenesis involved in differentiation](http://purl.obolibrary.org/obo/GO_0048942) EquivalentTo [cell morphogenesis](http://purl.obolibrary.org/obo/GO_0000902) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [posterior lateral line nerve glial cell development](http://purl.obolibrary.org/obo/GO_0048941)) + + +### postsynaptic cytosol `http://purl.obolibrary.org/obo/GO_0099524` + +#### Added +- [postsynaptic cytosol](http://purl.obolibrary.org/obo/GO_0099524) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0099524" + +- [postsynaptic cytosol](http://purl.obolibrary.org/obo/GO_0099524) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The region of the cytosol consisting of all cytosol that is part of the postsynapse." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dos" + +- [postsynaptic cytosol](http://purl.obolibrary.org/obo/GO_0099524) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [goslim_synapse](http://purl.obolibrary.org/obo/go#goslim_synapse) + +- [postsynaptic cytosol](http://purl.obolibrary.org/obo/GO_0099524) [label](http://www.w3.org/2000/01/rdf-schema#label) "postsynaptic cytosol" + +- [postsynaptic cytosol](http://purl.obolibrary.org/obo/GO_0099524) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "cellular_component" + +- Class: [postsynaptic cytosol](http://purl.obolibrary.org/obo/GO_0099524) + +- [postsynaptic cytosol](http://purl.obolibrary.org/obo/GO_0099524) EquivalentTo [cytosol](http://purl.obolibrary.org/obo/GO_0005829) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [cytosol](http://purl.obolibrary.org/obo/GO_0005829)) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [postsynapse](http://purl.obolibrary.org/obo/GO_0098794)) + +- [postsynaptic cytosol](http://purl.obolibrary.org/obo/GO_0099524) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [postsynapse](http://purl.obolibrary.org/obo/GO_0098794) + +- [postsynaptic cytosol](http://purl.obolibrary.org/obo/GO_0099524) SubClassOf [cytosolic region](http://purl.obolibrary.org/obo/GO_0099522) + + +### preceded by `http://purl.obolibrary.org/obo/BFO_0000062` +#### Removed +- [preceded by](http://purl.obolibrary.org/obo/BFO_0000062) [source](http://purl.org/dc/elements/1.1/source) "http://www.obofoundry.org/ro/#OBO_REL:preceded_by" + +#### Added +- [preceded by](http://purl.obolibrary.org/obo/BFO_0000062) [source](http://purl.org/dc/terms/source) "http://www.obofoundry.org/ro/#OBO_REL:preceded_by" + + +### presynaptic cytosol `http://purl.obolibrary.org/obo/GO_0099523` + +#### Added +- [presynaptic cytosol](http://purl.obolibrary.org/obo/GO_0099523) [label](http://www.w3.org/2000/01/rdf-schema#label) "presynaptic cytosol" + +- [presynaptic cytosol](http://purl.obolibrary.org/obo/GO_0099523) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "cellular_component" + +- [presynaptic cytosol](http://purl.obolibrary.org/obo/GO_0099523) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0099523" + +- [presynaptic cytosol](http://purl.obolibrary.org/obo/GO_0099523) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The region of the cytosol consisting of all cytosol that is part of the presynapse." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dos" + +- [presynaptic cytosol](http://purl.obolibrary.org/obo/GO_0099523) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [goslim_synapse](http://purl.obolibrary.org/obo/go#goslim_synapse) + +- Class: [presynaptic cytosol](http://purl.obolibrary.org/obo/GO_0099523) + +- [presynaptic cytosol](http://purl.obolibrary.org/obo/GO_0099523) EquivalentTo [cytosol](http://purl.obolibrary.org/obo/GO_0005829) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [cytosol](http://purl.obolibrary.org/obo/GO_0005829)) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [presynapse](http://purl.obolibrary.org/obo/GO_0098793)) + +- [presynaptic cytosol](http://purl.obolibrary.org/obo/GO_0099523) SubClassOf [cytosolic region](http://purl.obolibrary.org/obo/GO_0099522) + +- [presynaptic cytosol](http://purl.obolibrary.org/obo/GO_0099523) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [presynapse](http://purl.obolibrary.org/obo/GO_0098793) + + +### process utilizing autophagic mechanism `http://purl.obolibrary.org/obo/GO_0061919` +#### Removed +- [process utilizing autophagic mechanism](http://purl.obolibrary.org/obo/GO_0061919) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "dph" + +- [process utilizing autophagic mechanism](http://purl.obolibrary.org/obo/GO_0061919) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2017-07-13T19:42:14Z" + +- [process utilizing autophagic mechanism](http://purl.obolibrary.org/obo/GO_0061919) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0061919" + +- [process utilizing autophagic mechanism](http://purl.obolibrary.org/obo/GO_0061919) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate) + +- [process utilizing autophagic mechanism](http://purl.obolibrary.org/obo/GO_0061919) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" + +- [process utilizing autophagic mechanism](http://purl.obolibrary.org/obo/GO_0061919) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A cellular process involving delivery of a portion of the cytoplasm to lysosomes or to the plant or fungal vacuole that does not involve direct transport through the endocytic or vacuolar protein sorting (Vps) pathways. This process typically leads to degradation of the cargo; however, it can also be used to deliver resident proteins, such as in the cytoplasm-to-vacuole targeting (Cvt) pathway." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:21997368" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:28596378" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:22966490" + +- [process utilizing autophagic mechanism](http://purl.obolibrary.org/obo/GO_0061919) [label](http://www.w3.org/2000/01/rdf-schema#label) "process utilizing autophagic mechanism" + +- Class: [process utilizing autophagic mechanism](http://purl.obolibrary.org/obo/GO_0061919) + +- [process utilizing autophagic mechanism](http://purl.obolibrary.org/obo/GO_0061919) SubClassOf [cellular process](http://purl.obolibrary.org/obo/GO_0009987) + + + +### proerythroblast `http://purl.obolibrary.org/obo/CL_0000547` +#### Removed +- [proerythroblast](http://purl.obolibrary.org/obo/CL_0000547) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "An immature, nucleated erythrocyte occupying the stage of erythropoeisis that follows formation of erythroid progenitor cells. This cell is CD71-positive, has both a nucleus and a nucleolus, and lacks hematopoeitic lineage markers." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "MESH:A11.118.290.350.200" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ISBN:0721601464" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:1638021" + +#### Added +- [proerythroblast](http://purl.obolibrary.org/obo/CL_0000547) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "An immature, nucleated erythrocyte occupying the stage of erythropoeisis that follows formation of erythroid progenitor cells. This cell is CD71-positive, has both a nucleus and a nucleolus, and lacks hematopoeitic lineage markers." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ISBN:0721601464" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:1638021" + + +### professional antigen presenting cell `http://purl.obolibrary.org/obo/CL_0000145` +#### Removed +- [professional antigen presenting cell](http://purl.obolibrary.org/obo/CL_0000145) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "APC" + +#### Added +- [professional antigen presenting cell](http://purl.obolibrary.org/obo/CL_0000145) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "APC" + - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation) + + +### protein export from nucleus `http://purl.obolibrary.org/obo/GO_0006611` + +#### Added +- [protein export from nucleus](http://purl.obolibrary.org/obo/GO_0006611) [label](http://www.w3.org/2000/01/rdf-schema#label) "protein export from nucleus" + +- [protein export from nucleus](http://purl.obolibrary.org/obo/GO_0006611) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "protein-nucleus export" + +- [protein export from nucleus](http://purl.obolibrary.org/obo/GO_0006611) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0006611" + +- [protein export from nucleus](http://purl.obolibrary.org/obo/GO_0006611) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "copper-induced protein export from nucleus" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:al" + +- [protein export from nucleus](http://purl.obolibrary.org/obo/GO_0006611) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "protein export from cell nucleus" + +- [protein export from nucleus](http://purl.obolibrary.org/obo/GO_0006611) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "protein export out of nucleus" + +- [protein export from nucleus](http://purl.obolibrary.org/obo/GO_0006611) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The directed movement of a protein from the nucleus into the cytoplasm." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:jl" + +- [protein export from nucleus](http://purl.obolibrary.org/obo/GO_0006611) [has_alternative_id](http://www.geneontology.org/formats/oboInOwl#hasAlternativeId) "GO:0097349" + +- [protein export from nucleus](http://purl.obolibrary.org/obo/GO_0006611) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" + +- [protein export from nucleus](http://purl.obolibrary.org/obo/GO_0006611) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "protein transport from nucleus to cytoplasm" + +- Class: [protein export from nucleus](http://purl.obolibrary.org/obo/GO_0006611) + +- [protein export from nucleus](http://purl.obolibrary.org/obo/GO_0006611) EquivalentTo [transport](http://purl.obolibrary.org/obo/GO_0006810) and ([has target start location](http://purl.obolibrary.org/obo/RO_0002338) some [nuclear lumen](http://purl.obolibrary.org/obo/GO_0031981)) and ([has target end location](http://purl.obolibrary.org/obo/RO_0002339) some [cytosol](http://purl.obolibrary.org/obo/GO_0005829)) and ([results in transport across](http://purl.obolibrary.org/obo/RO_0002342) some [nuclear envelope](http://purl.obolibrary.org/obo/GO_0005635)) and ([has primary input](http://purl.obolibrary.org/obo/RO_0004009) some [protein](http://purl.obolibrary.org/obo/PR_000000001)) + +- [protein export from nucleus](http://purl.obolibrary.org/obo/GO_0006611) SubClassOf [nuclear export](http://purl.obolibrary.org/obo/GO_0051168) + +- [protein export from nucleus](http://purl.obolibrary.org/obo/GO_0006611) SubClassOf [intracellular protein transport](http://purl.obolibrary.org/obo/GO_0006886) + + +### protein import into nucleus `http://purl.obolibrary.org/obo/GO_0006606` + +#### Added +- [protein import into nucleus](http://purl.obolibrary.org/obo/GO_0006606) [label](http://www.w3.org/2000/01/rdf-schema#label) "protein import into nucleus" + +- [protein import into nucleus](http://purl.obolibrary.org/obo/GO_0006606) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The directed movement of a protein from the cytoplasm to the nucleus." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:jl" + +- [protein import into nucleus](http://purl.obolibrary.org/obo/GO_0006606) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0006606" + +- [protein import into nucleus](http://purl.obolibrary.org/obo/GO_0006606) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "protein transport from cytoplasm to nucleus" + +- [protein import into nucleus](http://purl.obolibrary.org/obo/GO_0006606) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" + +- [protein import into nucleus](http://purl.obolibrary.org/obo/GO_0006606) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "protein import into cell nucleus" + +- [protein import into nucleus](http://purl.obolibrary.org/obo/GO_0006606) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "establishment of protein localization to nucleus" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:mah" + +- [protein import into nucleus](http://purl.obolibrary.org/obo/GO_0006606) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "protein nucleus import" + +- Class: [protein import into nucleus](http://purl.obolibrary.org/obo/GO_0006606) + +- [protein import into nucleus](http://purl.obolibrary.org/obo/GO_0006606) EquivalentTo [transport](http://purl.obolibrary.org/obo/GO_0006810) and ([has target start location](http://purl.obolibrary.org/obo/RO_0002338) some [cytosol](http://purl.obolibrary.org/obo/GO_0005829)) and ([has target end location](http://purl.obolibrary.org/obo/RO_0002339) some [nuclear lumen](http://purl.obolibrary.org/obo/GO_0031981)) and ([results in transport across](http://purl.obolibrary.org/obo/RO_0002342) some [nuclear envelope](http://purl.obolibrary.org/obo/GO_0005635)) and ([has primary input](http://purl.obolibrary.org/obo/RO_0004009) some [protein](http://purl.obolibrary.org/obo/PR_000000001)) + +- [protein import into nucleus](http://purl.obolibrary.org/obo/GO_0006606) SubClassOf [intracellular protein transport](http://purl.obolibrary.org/obo/GO_0006886) + +- [protein import into nucleus](http://purl.obolibrary.org/obo/GO_0006606) SubClassOf [establishment of protein localization to organelle](http://purl.obolibrary.org/obo/GO_0072594) + +- [protein import into nucleus](http://purl.obolibrary.org/obo/GO_0006606) SubClassOf [protein localization to nucleus](http://purl.obolibrary.org/obo/GO_0034504) + +- [protein import into nucleus](http://purl.obolibrary.org/obo/GO_0006606) SubClassOf [import into nucleus](http://purl.obolibrary.org/obo/GO_0051170) + + +### protein kinase activity `http://purl.obolibrary.org/obo/GO_0004672` +#### Removed +- [protein kinase activity](http://purl.obolibrary.org/obo/GO_0004672) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "MetaCyc:PROTEIN-KINASE-RXN" + +- [protein kinase activity](http://purl.obolibrary.org/obo/GO_0004672) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "MetaCyc:PROTEIN-KINASE-RXN" + +#### Added +- [protein kinase activity](http://purl.obolibrary.org/obo/GO_0004672) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:25399640" + + +### protein serine/threonine kinase activity `http://purl.obolibrary.org/obo/GO_0004674` +#### Removed +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-432110" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-5682101" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-8856813" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "AAK1 phosphorylates AP-2 mu subunit at T156" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-5229343" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "AXIN is phosphorylated in the destruction complex" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-167084" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-9013978" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Phosphorylation of IRF-3/IRF7 and their release from the activated TLR3 complex" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-937059" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:TIRAP:activated TLR complex" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-8877691" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "MAP2K6 phosphorylates PIP4K2B" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-5607732" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "K63polyUb-TAK1 autophosphorylates" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-3857328" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "RPS6KA1/2/3 phosphorylates CEBPB on S321" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-450222" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Active p38 MAPK phosphorylates MAPKAPK2 or 3" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-450463" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "MK2 phosphorylates ZFP36 (Tristetraproline, TTP)" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-2028629" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Phosphorylation of MOB1A and B by p-STK4 (p-MST1)" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-2470508" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "ACVR2A,B (ActRIIA,B) phosphorylates ACVR1C (ActRIC, ALK7) in response to Activin" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-198756" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "ERK1/2 phosphorylates MSK1" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-112381" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-77071" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Phosphorylation (Ser5) of RNA pol II CTD" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-6805785" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "AKT phosphorylates PHF20" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-2730856" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Autophosphorylation of PAK" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-2399977" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "AKT1 E17K mutant phosphorylates AKT1S1 (PRAS40)" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-5668984" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "PAK1 or PAK2 phosphorylates MYLK" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-419644" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Transphosphorylation of pLIMK1" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-9008480" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "GSK3B phosphorylates RUNX2" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-2396007" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "IRF3 is phosphorylated by TBK1" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-1225894" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Type II Activin Receptor (ActRIIB/ACVR2B) phosphorylates Type I Activin Receptor (ActRIC/ACVR1C) in response to NODAL" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-2400001" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "AKT1 E17K mutant phosphorylates CHUK (IKKalpha)" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-3209160" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Activated ERKs phosphorylate ERF" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-8868666" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "CDK5:p25 phosphorylates JUN" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-5213464" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "RIPK1 is phosphorylated" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-5674496" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Activated MAPKs phosphorylate MAP2K1" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-451347" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Activation of JNK by DSCAM" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-2984226" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "PLK1 phosphorylates NEK9" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-1449597" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "p-AKT2 phosphorylates Myosin 5A" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-202459" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Phosphorylation of Bcl10" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-9656215" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "RAF1 mutant complexes phosphorylate MAP2K dimer" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-6802973" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "PLK3 phosphorylates CDC25C" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-9612501" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "SGK phosphorylates CREB1" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-3858480" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "WNT-dependent phosphorylation of DVL" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-429714" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "monophospho-CERT + 2 ATP => multiphospho-CERT + 2 ADP" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-5672010" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Active MTORC1 phosphorylates ULK1" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-2466068" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Phosphorylation of cohesin by PLK1 at chromosomal arms" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-198621" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "AKT phosphorylates caspase-9" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-9699579" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "AKT phosphorylates FOXO3 downstream of FLT3" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-6804276" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "ATM phosphorylates TTC5" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-975853" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Multiple IRAK1 autophosphorylation within the complex p-IRAK4:oligo MyD88:activated TLR" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-8878050" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "HIPK2 phosphorylates RUNX1 and EP300" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-8939963" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Activated AKT phosphorylates RUNX2" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-198599" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "AKT phosphorylates MDM2" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-198611" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "AKT phosphorylates IKKalpha" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-9610153" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-111919" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "PKA phosphorylates CREB1" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-5632670" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "CSNK1A1 phosphorylates SMO dimer" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-349426" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Phosphorylation of MDM4 by CHEK2" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-202437" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Phosphorylation of CARMA1" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:2956925" + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:bf" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-211164" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "AKT phosphorylates FOXO1A" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-2399981" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "AKT1 E17K mutant phosphorylates MDM2" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-451152" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "MAP kinase p38 phosphorylates KSRP" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-170116" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Myt-1 mediated phosphorylation of Cyclin A:Cdc2" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-399978" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Protein kinase C, alpha type phosphorylates MARCKS" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-5684140" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "ATM phosphorylates RBBP8" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-5693536" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "ATM phosphorylates MDC1" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-6805285" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "PLK3 phosphorylates TP53" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-9620004" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "RSKs autophosphorylate" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-9008822" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "PPM1D dephosphorylates RUNX2" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-5218814" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "PAK2 autophorylates" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-5684887" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Activation of CHEK1 at resected DNA DSBs" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-400382" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "CSNK1E,CSNK1D phosphorylate CRY and PER proteins" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-5672978" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "RAF phosphorylates MAP2K dimer" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-8944454" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "mTORC1 phosphorylates MAF1" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-6800490" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "ATM phosphorylates PIDD1" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-1549526" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Phosphorylation of SMAD2,3 by Activin:Activin Receptor" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-193647" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "IRAK is activated" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-912470" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "ATR phosphorylates Histone H2A.X at unsynapsed regions" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-2993898" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "VRK1/VRK2 phosphorylate BANF1" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-9817397" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "TBK1, IKBKE phosphorylate RIPK1 at T189" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-9632868" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "CDKN1B is phosphorylated in response to estrogen" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-198640" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "TORC2 (mTOR) phosphorylates AKT at S473" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-5610718" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "CK1 phosphorylates p-GLI2" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-399952" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Phosphorylation of LIMK-1 by PAK" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-2028598" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Phosphorylation of YAP by LATS1" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-6802933" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "p-BRAF and RAF fusion dimers phosphorylate MAP2Ks" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-5687101" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "p-T182 MAPKAPK5 phosphorylates FOXO3" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "serine/threonine protein kinase activity" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "EC:2.7.11.1" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-8868260" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "CDK5:p25 phosphorylates GOLGA2" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-195275" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Phosphorylation of APC component of the destruction complex" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-5671919" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Activated CIT phosphorylates MRLCs" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-5686704" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Activated ATM phosphorylates DCLRE1C" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-5687086" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "PAK1,2,3 phosphorylates MAPK6,4" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-166245" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-139918" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Phosphorylation of BIM by JNK" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-9731111" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "MAPK1 and MAPK3 phosphorylate SMAD2 and SMAD3" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-162363" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "p-T309,S474-AKT2:PIP3 phosphorylates PDE3B" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-5692775" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "SEPT7:p-S189 MAPK6:p-T182 MAPKAPK5 phosphorylates CDC42EPs" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-200421" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Activation of cytosolic AMPK by phosphorylation" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-349455" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Phosphorylation of MDM4 by ATM" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-193705" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "IKKbeta phosphorylates IkB causing NF-kB to dissociate" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "protein threonine kinase activity" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-2730876" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Phosphorylation of IKK-beta by TAK1" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-5665868" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "AMPK (complex) phosphorylates ULK1 (complex)" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-9612509" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "SGK phosphorylates SRF" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-937022" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "IRAK4 autophosphorylation in the complex with activated TLR:MyD88:TIRAP" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-9648089" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "NEK6 and NEK7 phosphorylate EML4" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-9009208" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Activated ERKs phosphorylate RUNX2" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-109822" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-3371531" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Constitutive phosphorylation by pERK1/2" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-2060328" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Phosphorylation of WWTR1 (TAZ) by LATS1" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-8863895" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "IKKB phosphorylates SNAP23" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-2243942" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "PDPK1 phosphorylates AKT1 E17K mutant" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-2028555" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Phosphorylation of LATS1 and 2 by p-STK4 (p-MST1)" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-174119" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Free APC/C phosphorylated by Plk1" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-9729318" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "CSNK1A1 phosphorylates nucleoprotein" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-5693551" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Phosphorylation of BRCA1-A complex at multiple sites by ATM" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-6795460" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "SGK1 phosphorylates MDM2" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-201691" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Phosphorylation of LRP5/6 cytoplasmic domain by CSNKI" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-3249371" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "TBK1 phosphorylates STAT6 at Ser407" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-5687121" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "p-S MAPKAPK5 phosphorylates HSPB1" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-6799246" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "CHEK1 phosphorylates TP53" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-198371" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "AKT phosphorylates GSK3" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-3857329" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-450827" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "hp-IRAK1, hp-IRAK4 4 phosphorylate Pellino-1 and 2." + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-156699" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Inactivation of Wee1 kinase" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-165692" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Phosphorylation of 4E-BP1 by activated mTORC1" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-3229152" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "MAP3K5 (ASK1) phosphorylates MAP2K4 (SEK1)" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-109823" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-8873929" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Casein kinase II phosphorylates STARD10" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-2990880" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "NEK6/NEK7 phosphorylates NUP98" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-170076" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-2399969" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "AKT1 E17K mutant phosphorylates p21Cip1 and p27Kip1" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-6798372" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "ATM phosphorylates DYRK2" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-9633742" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "EIF2AK4 (GCN2) dimer autophosphorylates" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-2028679" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Phosphorylation of LATS1 and 2 by p-STK4(MST1)/N" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-163416" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "hormone-sensitive lipase (HSL) + 2 ATP -> phosphorylated HSL + 2 ADP" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-2028661" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Phosphorylation of WWTR1 (TAZ) by LATS2" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-2028675" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Phosphorylation of MOB1A and B by p-STK3(MST2)/N" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-9656214" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "MAP2Ks phosphorylate MAPKs downstream of RAF1 mutants" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-3000310" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "AURKA phosphorylates PLK1" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-168053" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Phosphorylated MAPKs phosphorylate ATF-2" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-8942836" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-4088134" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "PLK1 phosphorylates FOXM1" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-162657" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Inactivation of Myt1 kinase" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-5610722" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "CK1 phosphorylates p-GLI3" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-6810233" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-199917" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "MAPKAPK2 phosphorylates CREB at Serine 133" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-9032863" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "CDK5 phosphorylates NTRK2" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-8863007" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "p25-bound CDK5 phosphorylates CDC25B" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-199929" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "ERK5 activates the transcription factor MEF2" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-975134" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Second phosphorylation of IRAK1 by IRAK4 bound to MyD88: activated TLR 7/8 or 9" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-199895" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "RSK1/2/3 phosphorylates CREB at Serine 133" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "serine kinase activity" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "EC:2.7.11.1" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-5683801" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "CHEK2 phosphorylates BRCA1" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-187688" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-198347" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "AKT phosphorylates BAD" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-9012319" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "p-TEFb phosphorylates serine 2 in RNA polymerase II CTD" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-5683964" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "ATM phosphorylates EYA1-4" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-4332363" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Autophosphorylation and activation of CAMK2" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-450499" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Protein Kinase B (AKT) phosphorylates KSRP" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-9762094" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "GSK3B phosphorylates p-NFE2L2" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-3239019" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Active p38 MAPK phosphorylates MAPKAPK5" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-156678" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Activation of Cdc25C" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-69891" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Phosphorylation and activation of CHEK2 by ATM" + +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-6799097" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "ATM phosphorylates ZNF420" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-9725030" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "MAPK1 phsophorylates ZC3HCF1 in a NPM-ALK-dependent manner" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-211583" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Partial autophosphorylation of PAK-2 at Ser-19, Ser-20, Ser-55, Ser-192, and Ser-197" -### metanephric mesenchyme stem cell `http://purl.obolibrary.org/obo/CL_0000324` -#### Removed -- [metanephric mesenchyme stem cell](http://purl.obolibrary.org/obo/CL_0000324) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-5672828" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "mTORC1 phosphorylates AKT1S1" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-202541" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-8940100" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "CDK1 phosphorylates VCPIP1" -### metanephros induced blastemal cells `http://purl.obolibrary.org/obo/UBERON_0010531` -#### Removed -- [metanephros induced blastemal cells](http://purl.obolibrary.org/obo/UBERON_0010531) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-3132737" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "MAPKs phosphorylate ETS1 and ETS2" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-3222020" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "NUAK1 phosphorylates TP53" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-6804955" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "ATM phosphorylates MDM2" -### metapodial skeleton `http://purl.obolibrary.org/obo/UBERON_0010546` -#### Removed -- [metapodial skeleton](http://purl.obolibrary.org/obo/UBERON_0010546) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-211650" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Autophosphorylation of PAK-2p34 in the activation loop" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-5082387" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Phosphorylation of HSF1 at Ser230 induces transactivation" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-3228469" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "MAP3K5 phosphorylates MKK3 and MKK6" -### metapodium region `http://purl.obolibrary.org/obo/UBERON_0009877` -#### Removed -- [metapodium region](http://purl.obolibrary.org/obo/UBERON_0009877) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-5635842" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "ULK3 phosphorylates GLI" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-8952289" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "FAM20C phosphorylates FAM20C substrates" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-6799332" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "ATR phosphorylates TP53" -### metastasis-suppressor KiSS-1 `http://purl.obolibrary.org/obo/PR_000009344` +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-9648888" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "p-T,T486,T488-EIF2AK1 phosphorylates EIF2S1 (eIF2-alpha)" -#### Added -- [metastasis-suppressor KiSS-1](http://purl.obolibrary.org/obo/PR_000009344) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [metastasis-suppressor KiSS-1 (human)](http://purl.obolibrary.org/obo/PR_Q15726) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-446694" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "IRAK4 phosphorylates IRAK1" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-8948146" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "FUNDC1 is phosphorylated by ULK1 at Ser17" -### microglial cell `http://purl.obolibrary.org/obo/CL_0000129` -#### Removed -- [microglial cell](http://purl.obolibrary.org/obo/CL_0000129) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "microglia" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "molecular_function" -- [microglial cell](http://purl.obolibrary.org/obo/CL_0000129) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-201677" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta" -#### Added -- [microglial cell](http://purl.obolibrary.org/obo/CL_0000129) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "microglia" - - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [plural term](http://purl.obolibrary.org/obo/uberon#PLURAL) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-8852317" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "PLK1 phosphorylates GTSE1" - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1038/s41598-020-66092-9" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-5682983" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "ATM phosphorylates WHSC1" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-2176475" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9" -### midbrain dopaminergic neuron `http://purl.obolibrary.org/obo/CL_2000097` -#### Removed -- [midbrain dopaminergic neuron](http://purl.obolibrary.org/obo/CL_2000097) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-170055" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [label](http://www.w3.org/2000/01/rdf-schema#label) "protein serine/threonine kinase activity" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-2399966" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "AKT1 E17K mutant phosphorylates GSK3" -### molecular layer of cerebellar cortex `http://purl.obolibrary.org/obo/UBERON_0002974` -#### Removed -- [molecular layer of cerebellar cortex](http://purl.obolibrary.org/obo/UBERON_0002974) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "serine(threonine) protein kinase activity" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "EC:2.7.11.1" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-446701" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "IRAK4-activated IRAK1 autophosphorylates" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-5687183" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "PRKDC phosphorylates DCLRE1C at DNA DSBs" -### monoblast `http://purl.obolibrary.org/obo/CL_0000040` -#### Removed -- [monoblast](http://purl.obolibrary.org/obo/CL_0000040) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-199839" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "AKT can phosphorylate RSK" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-1592233" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "p38 MAPK phosphorylates PPARGC1A" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-8853419" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "TPX2 promotes AURKA autophosphorylation" -### mouth `http://purl.obolibrary.org/obo/UBERON_0000165` -#### Removed -- [mouth](http://purl.obolibrary.org/obo/UBERON_0000165) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-450474" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "MK2 phosphorylates BRF1" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-9683664" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "GSK3 phosphorylates Nucleoprotein" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-9673346" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Unknown kinase phosphorylates p-DVL" -### multi-limb segment region `http://purl.obolibrary.org/obo/UBERON_0006058` -#### Removed -- [multi-limb segment region](http://purl.obolibrary.org/obo/UBERON_0006058) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-165182" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Phosphorylation of complexed TSC2 by PKB" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0004674" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-975170" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "IRAK4 autophosphorylation in the complex with MyD88:activated TLR 7/8 or 9" -### muscle cell `http://purl.obolibrary.org/obo/CL_0000187` -#### Removed -- [muscle cell](http://purl.obolibrary.org/obo/CL_0000187) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-9604328" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "AKT1 phosphorylates NOTCH4" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-450490" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Protein Kinase B/Akt phosphorylates BRF1" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-1458463" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "p-AKT2 phosphorylates RGC2" -### muscle precursor cell `http://purl.obolibrary.org/obo/CL_0000680` -#### Removed -- [muscle precursor cell](http://purl.obolibrary.org/obo/CL_0000680) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-2028284" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Phosphorylation of STK4 (MST1) and SAV1 by STK4" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-2529020" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "CK2 phosphorylates condensin I subunits" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-5627775" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Autophosphorylation of PAK1,2,3" -### muscle structure `http://purl.obolibrary.org/obo/UBERON_0005090` -#### Removed -- [muscle structure](http://purl.obolibrary.org/obo/UBERON_0005090) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-9619515" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "AMPK phosphorylates MAPT" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-5686578" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Activated ATM phosphorylates ABL1" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-5610730" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "GSK3 phosphorylates p-GLI2" -### musculature `http://purl.obolibrary.org/obo/UBERON_0001015` -#### Removed -- [musculature](http://purl.obolibrary.org/obo/UBERON_0001015) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-5685156" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "ATR phosphorylates RPA2" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-1181149" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "ACVR2A,B (ActRIIA,B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "protein-serine kinase activity" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "EC:2.7.11.1" -### musculature of body `http://purl.obolibrary.org/obo/UBERON_0000383` -#### Removed -- [musculature of body](http://purl.obolibrary.org/obo/UBERON_0000383) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-2028591" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Phosphorylation of STK3 (MST2) and SAV1 by STK3" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-6805126" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "AURKB phosphorylates TP53" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "protein serine kinase activity" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "EC:2.7.11.1" -### musculature of hip `http://purl.obolibrary.org/obo/UBERON_0004475` -#### Removed -- [musculature of hip](http://purl.obolibrary.org/obo/UBERON_0004475) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-450346" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "activated human TAK1 phosphorylates MKK3/MKK6" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-5624492" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "PAK phosphorylates p21 RAF1 on S338" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-165758" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Phosphorylation and inactivation of eEF2K by activated S6K1" -### musculature of shoulder `http://purl.obolibrary.org/obo/UBERON_0004476` -#### Removed -- [musculature of shoulder](http://purl.obolibrary.org/obo/UBERON_0004476) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-166286" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Multiple IRAK1 autophosphorylation steps" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-1168638" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Activated IKK phosphorylates I-kappaB" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-195283" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Phosphorylation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3" -### musculoskeletal system `http://purl.obolibrary.org/obo/UBERON_0002204` -#### Removed -- [musculoskeletal system](http://purl.obolibrary.org/obo/UBERON_0002204) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-3928620" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "PAK1 autophosphorylates" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-936951" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Activation of TAK1 complex bound to activated TLR4 complex" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-975160" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:activated TLR 7/8 or 9" -### myeloid cell `http://purl.obolibrary.org/obo/CL_0000763` -#### Removed -- [myeloid cell](http://purl.obolibrary.org/obo/CL_0000763) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-3222006" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "STK11 (LKB1) phosphorylates NUAK1" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-6798374" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "DYRK2 phosphorylates TP53" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-5682026" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "MRN bound to shortened telomeres activates ATM" -### myeloid suppressor cell `http://purl.obolibrary.org/obo/CL_0000889` -#### Removed -- [myeloid suppressor cell](http://purl.obolibrary.org/obo/CL_0000889) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-2562526" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "PLK1 phosphorylates OPTN" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-202500" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Activation of IKK complex" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-2422927" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "MAPK3-3 or MAPK1 phosphorylate GORASP2" -### myeloperoxidase `http://purl.obolibrary.org/obo/PR_000010543` +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-6805640" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "AKT phosphorylates KAT6A" -#### Added -- [myeloperoxidase](http://purl.obolibrary.org/obo/PR_000010543) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [myeloperoxidase (human)](http://purl.obolibrary.org/obo/PR_P05164) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-5693575" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "DNA-PKcs autophosphorylates" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-9818789" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "CHUK, IKBKB phosphorylate RIPK1 at S25" -### myoepithelium `http://purl.obolibrary.org/obo/UBERON_0000420` -#### Removed -- [myoepithelium](http://purl.obolibrary.org/obo/UBERON_0000420) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-450325" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "c-FOS activation by phospho ERK1/2" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-187949" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "CAK-mediated phosphorylation of Cyclin A:Cdk2" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-199935" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "MSK1 activates CREB" -### myotome `http://purl.obolibrary.org/obo/UBERON_0003082` -#### Removed -- [myotome](http://purl.obolibrary.org/obo/UBERON_0003082) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-195300" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-5693609" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "ATM phosphorylates TP53 at S15" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-170087" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes" -### named class expression `http://purl.obolibrary.org/obo/IAO_0000421` +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-165766" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Phosphorylation and activation of eIF4G by activated S6K1" -#### Added -- [named class expression](http://purl.obolibrary.org/obo/IAO_0000421) [editor note](http://purl.obolibrary.org/obo/IAO_0000116) "named class expressions are used in order to have more concise logical definition but their extensions may not be interesting classes on their own. In languages such as OWL, with no provisions for macros, these show up as actuall classes. Tools may with to not show them as such, and to replace uses of the macros with their expansions"@en +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-6814409" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "CK2 phosphorylates PDCL" -- [named class expression](http://purl.obolibrary.org/obo/IAO_0000421) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "named class expression"@en +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-188350" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "CAK-mediated phosphorylation of Cyclin E:Cdk2" -- [named class expression](http://purl.obolibrary.org/obo/IAO_0000421) [IAO_0000117](http://purl.obolibrary.org/obo/IAO_0000117) "Alan Ruttenberg"@en +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-2399982" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "AKT1 E17K mutant phosphorylates TSC2, inhibiting it" -- [named class expression](http://purl.obolibrary.org/obo/IAO_0000421) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A named class expression is a logical expression that is given a name. The name can be used in place of the expression."@en +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-2574840" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "AJUBA facilitates AURKA autophosphorylation" -- [named class expression](http://purl.obolibrary.org/obo/IAO_0000421) [label](http://www.w3.org/2000/01/rdf-schema#label) "named class expression"@en +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-69685" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "CHEK2 phosphorylates TP53" -- Individual: [named class expression](http://purl.obolibrary.org/obo/IAO_0000421) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-442832" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "PAK phosphorylates cortactin" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-2399992" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "AKT1 E17K mutant phosphorylates forkhead box transcription factors" -### nasal cavity `http://purl.obolibrary.org/obo/UBERON_0001707` -#### Removed -- [nasal cavity](http://purl.obolibrary.org/obo/UBERON_0001707) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-2399985" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "AKT1 E17K mutant phosphorylates caspase-9" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-2028670" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Phosphorylation of MOB1A and B by p-STK4(MST1)/N" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-5218916" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "p-MAPK2/3 phosphorylates HSP27" -### nasal skeleton `http://purl.obolibrary.org/obo/UBERON_0006813` -#### Removed -- [nasal skeleton](http://purl.obolibrary.org/obo/UBERON_0006813) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-9627089" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "CASP9 is phosphorylated at T125" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-4332388" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Activation of MAP3K7 in response to WNT" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-6805399" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "TAF1 phosphorylates TP53" -### nasolacrimal duct `http://purl.obolibrary.org/obo/UBERON_0002392` -#### Removed -- [nasolacrimal duct](http://purl.obolibrary.org/obo/UBERON_0002392) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-399939" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Autophosphorylation of PAK" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "threonine-specific protein kinase activity" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "EC:2.7.11.1" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-170977" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "FRS2 is phosphorylated by active TrkA receptor" -### nasolacrimal groove `http://purl.obolibrary.org/obo/UBERON_0006266` -#### Removed -- [nasolacrimal groove](http://purl.obolibrary.org/obo/UBERON_0006266) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-381091" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "IRE1 dimer autophosphorylates" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-975878" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-2399941" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "AKT1 E17K mutant phosphorylates BAD" -### natural cytotoxicity triggering receptor 1 `http://purl.obolibrary.org/obo/PR_000001893` +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-933525" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Phosphorylation and release of IRF7" -#### Added -- [natural cytotoxicity triggering receptor 1](http://purl.obolibrary.org/obo/PR_000001893) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [natural cytotoxicity triggering receptor 1 (human)](http://purl.obolibrary.org/obo/PR_O76036) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-4793911" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "MAPKAPK2 phosphorylates HSF1" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-9769115" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "MAPK1,(MAPK3) phosphorylates NPAS4" -### natural cytotoxicity triggering receptor 2 `http://purl.obolibrary.org/obo/PR_000001894` +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-9624526" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "AKT phosphorylates FOXO3 downstream of ESR1 and EGFR" -#### Added -- [natural cytotoxicity triggering receptor 2](http://purl.obolibrary.org/obo/PR_000001894) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [natural cytotoxicity triggering receptor 2 (human)](http://purl.obolibrary.org/obo/PR_O95944) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-5213466" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "RIPK3 is phosphorylated" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-6805103" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "AURKA phosphorylates TP53" -### natural helper lymphocyte `http://purl.obolibrary.org/obo/CL_0002679` -#### Removed -- [natural helper lymphocyte](http://purl.obolibrary.org/obo/CL_0002679) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-2730896" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Phosphorylation of MEK4 by MEKK1" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-176298" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Activation of claspin" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-9626880" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "MAPK11 or MAPK14 phosphorylates NCF1 at Ser345" -### natural killer cell receptor 2B4 `http://purl.obolibrary.org/obo/PR_000001896` +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-165777" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Phosphorylation and activation of eIF4B by activated S6K1" -#### Added -- [natural killer cell receptor 2B4](http://purl.obolibrary.org/obo/PR_000001896) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [natural killer cell receptor 2B4 (human)](http://purl.obolibrary.org/obo/PR_Q9BZW8) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-198613" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "AKT phosphorylates p21Cip1 and p27Kip1" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-5682598" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "ATM phosphorylates HERC2" -### near-projecting glutamatergic cortical neuron `http://purl.obolibrary.org/obo/CL_4023012` +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-9032751" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Estrogen-independent phosphorylation of ESR1 S118 by MAPK1 and MAPK3" -#### Added -- [near-projecting glutamatergic cortical neuron](http://purl.obolibrary.org/obo/CL_4023012) [symbol](http://purl.obolibrary.org/obo/IAO_0000028) "NP glut neuron" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [has_alternative_id](http://www.geneontology.org/formats/oboInOwl#hasAlternativeId) "GO:0004696" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-198746" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "ERK1/2/5 activate RSK1/2/3" -### nephrogenic cord `http://purl.obolibrary.org/obo/UBERON_0004875` -#### Removed -- [nephrogenic cord](http://purl.obolibrary.org/obo/UBERON_0004875) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-5675868" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "ULK1 phosphorylates ATG13 and RB1CC1" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-6805276" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "CDK5 phosphorylates TP53" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-8948757" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "AKT phosphorylates MKRN1" -### nephrogenic mesenchyme `http://purl.obolibrary.org/obo/UBERON_0004208` -#### Removed -- [nephrogenic mesenchyme](http://purl.obolibrary.org/obo/UBERON_0004208) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-5218826" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-2399988" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "AKT1 E17K mutant phosphorylates NR4A1 (NUR77)" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-8863014" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "p25-bound CDK5 phosphorylates CDC25A" -### nephron `http://purl.obolibrary.org/obo/UBERON_0001285` -#### Removed -- [nephron](http://purl.obolibrary.org/obo/UBERON_0001285) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-2214351" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "PLK1 phosphorylates GORASP1" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-9633008" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "p-T899-EIF2AK4 (GCN2) phosphorylates EIF2AS1" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-9634702" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "LINC01139 promotes phosphorylation of HIF1A by LRRK2" -### nephron progenitor `http://purl.obolibrary.org/obo/UBERON_0010536` -#### Removed -- [nephron progenitor](http://purl.obolibrary.org/obo/UBERON_0010536) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-2430535" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "MASTL phosphorylates ENSA" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-374696" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Phosphorylation of L1 by p90rsk" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-975874" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Second phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR complex" -### nephron tubule `http://purl.obolibrary.org/obo/UBERON_0001231` -#### Removed -- [nephron tubule](http://purl.obolibrary.org/obo/UBERON_0001231) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-5669250" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "PAK1 phosphorylates FLNA" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [has_alternative_id](http://www.geneontology.org/formats/oboInOwl#hasAlternativeId) "GO:0004700" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-6802935" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "MAPKs are phosphorylated downstream of BRAF and RAF fusion dimers" -### neprilysin `http://purl.obolibrary.org/obo/PR_000001898` +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "EC:2.7.11.1" + - [source](http://www.geneontology.org/formats/oboInOwl#source) "skos:exactMatch" -#### Added -- [neprilysin](http://purl.obolibrary.org/obo/PR_000001898) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [neprilysin (human)](http://purl.obolibrary.org/obo/PR_P08473) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-5693540" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "MRN activates ATM" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-8932322" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "CK2 phosphorylates NFE2L2" -### nerve innervating pinna `http://purl.obolibrary.org/obo/UBERON_0035648` -#### Removed -- [nerve innervating pinna](http://purl.obolibrary.org/obo/UBERON_0035648) SubClassOf [neuron projection bundle](http://purl.obolibrary.org/obo/CARO_0001001) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-5684096" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "CDK2 phosphorylates RBBP8" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-112342" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Inactivation of MAP2K1 by CDK1" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-2029469" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "p-ERK phosphorylates WAVEs and ABI" -### nerve of clitoris `http://purl.obolibrary.org/obo/UBERON_0035650` -#### Removed -- [nerve of clitoris](http://purl.obolibrary.org/obo/UBERON_0035650) SubClassOf [neuron projection bundle](http://purl.obolibrary.org/obo/CARO_0001001) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-5668545" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "NIK autophosphorylates on T559" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-8850945" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Casein kinase II phosphorylates PTEN" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-5690250" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "p-T182-MAPKAPK5 phoshphorylates DNAJB1" -### nerve of penis `http://purl.obolibrary.org/obo/UBERON_0035649` -#### Removed -- [nerve of penis](http://purl.obolibrary.org/obo/UBERON_0035649) SubClassOf [neuron projection bundle](http://purl.obolibrary.org/obo/CARO_0001001) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-6811454" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "MAPKs phosphorylate PP2A" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-8852306" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Mitotic phosphorylation-induced dissociation of GTSE1 from microtubule plus ends" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-174174" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Phosphorylation of the Emi1 DSGxxS degron by Plk1" -### nervous system `http://purl.obolibrary.org/obo/UBERON_0001016` -#### Removed -- [nervous system](http://purl.obolibrary.org/obo/UBERON_0001016) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-1632857" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "ULK1 phosphorylates AMBRA1:BECN1 complex" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-5578777" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "DMPK phosphorylates PLN" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-9705323" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Phosphorylation of TBK1/IKBKE" -### netrin-G1 `http://purl.obolibrary.org/obo/PR_000011467` +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-6802919" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "RAS:GTP:moderate kinase activity p-RAF complexes phosphorylate MAP2Ks" -#### Added -- [netrin-G1](http://purl.obolibrary.org/obo/PR_000011467) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [netrin-G1 (human)](http://purl.obolibrary.org/obo/PR_Q9Y2I2) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-2730868" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Phosphorylation of MEK7 by MEKK1" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-9619843" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "ERKs phosphorylate RSKs" -### neural cell adhesion molecule 1 `http://purl.obolibrary.org/obo/PR_000001024` +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-419083" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Myosin phosphatase inactivation by ROCK" -#### Added -- [neural cell adhesion molecule 1](http://purl.obolibrary.org/obo/PR_000001024) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [neural cell adhesion molecule 1 (human)](http://purl.obolibrary.org/obo/PR_P13591) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-918229" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Phosphorylation and release of IRF3/IRF7" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-442724" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs)" -### neural crest derived neuron `http://purl.obolibrary.org/obo/CL_0000029` -#### Removed -- [neural crest derived neuron](http://purl.obolibrary.org/obo/CL_0000029) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-399950" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Phosphorylation of cofilin by LIMK-1" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-2399999" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "AKT1 E17K mutant phosphorylates RSK" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-4332358" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Dissociation of CaM and CAMK2 autophosphorylation" -### neural plate `http://purl.obolibrary.org/obo/UBERON_0003075` -#### Removed -- [neural plate](http://purl.obolibrary.org/obo/UBERON_0003075) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-163418" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "perilipin + 2 ATP -> phosphorylated perilipin + 2 ADP" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-167098" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Phosphorylation (Ser5) of RNA pol II CTD" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-199910" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "MSK1 activates ATF1" -### neural stem cell `http://purl.obolibrary.org/obo/CL_0000047` -#### Removed -- [neural stem cell](http://purl.obolibrary.org/obo/CL_0000047) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-5218854" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "p-Y420-FYN is phosphorylated on S21" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-381111" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-9610163" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "BRAF autophosphorylates downstream of RAP1 and NGF" -### neural tissue `http://purl.obolibrary.org/obo/UBERON_0003714` -#### Removed -- [neural tissue](http://purl.obolibrary.org/obo/UBERON_0003714) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-139908" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Phosphorylation of DLC2 by MAPK8" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-8876446" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "p-ULK1 phosphorylates DENND3" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-170126" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Phosphorylation of Cyclin B1 in the CRS domain" -### neural tube basal plate `http://purl.obolibrary.org/obo/UBERON_0004064` -#### Removed -- [neural tube basal plate](http://purl.obolibrary.org/obo/UBERON_0004064) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-75010" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Phosphorylation of Cdc25C at Ser 216 by Chk1" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-5692779" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "p-S182 MAPKAPK5 phosphorylates FOXO1" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-5610732" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "GSK3 phosphorylates p-GLI3" -### neural tube mantle layer `http://purl.obolibrary.org/obo/UBERON_0004061` -#### Removed -- [neural tube mantle layer](http://purl.obolibrary.org/obo/UBERON_0004061) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-6805479" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "TP53RK phosphorylates TP53" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-9729260" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "GSK3 phosphorylates nucleoprotein" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-448948" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Phosphorylation of E proteins by p38 MAPK" -### neural tube marginal layer `http://purl.obolibrary.org/obo/UBERON_0004062` -#### Removed -- [neural tube marginal layer](http://purl.obolibrary.org/obo/UBERON_0004062) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-5607726" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-6795473" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "PDPK1 phosphorylates SGK1" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-201717" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "CSNK2-mediated phosphorylation of DVL" -### neurocranium `http://purl.obolibrary.org/obo/UBERON_0001703` -#### Removed -- [neurocranium](http://purl.obolibrary.org/obo/UBERON_0001703) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "protein serine-threonine kinase activity" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "EC:2.7.11.1" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-5685230" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "CHEK1 phosphorylates RAD51" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-5607742" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta" -### neurogenic placode `http://purl.obolibrary.org/obo/UBERON_0009955` -#### Removed -- [neurogenic placode](http://purl.obolibrary.org/obo/UBERON_0009955) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-8948039" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "FUNDC1 is phosphorylated by CK2" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-195287" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-448955" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Phosphorylation of MEF2 proteins by p38" -### neurogliaform lamp5 GABAergic cortical interneuron (Mmus) `http://purl.obolibrary.org/obo/CL_4023024` +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-8854908" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "PKA phosphorylates RET:GDNF:GFRA dimer" -#### Added -- [neurogliaform lamp5 GABAergic cortical interneuron (Mmus)](http://purl.obolibrary.org/obo/CL_4023024) [symbol](http://purl.obolibrary.org/obo/IAO_0000028) "NGC Lamp5 interneuron (Mus)" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-163010" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Down Regulation of Emi1 through Phosphorylation of Emi1" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-8878054" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "HIPK2 phosphorylates RUNX1" -### neuromast hair cell `http://purl.obolibrary.org/obo/CL_0000856` -#### Removed -- [neuromast hair cell](http://purl.obolibrary.org/obo/CL_0000856) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-429016" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "ALOX5 is phosphorylated by MAPKAP2" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-2294580" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "PLK1 hyperphosphorylates Condensin II complex" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-9766532" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "SQSTM1 oligomer is phosphorylated" -### neuron associated cell `http://purl.obolibrary.org/obo/CL_0000095` -#### Removed -- [neuron associated cell](http://purl.obolibrary.org/obo/CL_0000095) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-9022314" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "HIPK2 phosphorylates MECP2" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-3229102" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "p-MAPKAPK3 phosphorylates BMI1" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-6801675" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "PLK2 phosphorylates NPM1" -### neuron projection bundle `http://purl.obolibrary.org/obo/CARO_0001001` -#### Removed -- [neuron projection bundle](http://purl.obolibrary.org/obo/CARO_0001001) [label](http://www.w3.org/2000/01/rdf-schema#label) "neuron projection bundle" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-75820" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta" -- [neuron projection bundle](http://purl.obolibrary.org/obo/CARO_0001001) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A fasciculated bundle of neuron projections (GO:0043005), largely or completely lacking synapses." +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-8863011" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "p25-bound CDK5 phosphorylates CDC25C" -- [neuron projection bundle](http://purl.obolibrary.org/obo/CARO_0001001) [id](http://www.geneontology.org/formats/oboInOwl#id) "CARO:0001001" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [has_alternative_id](http://www.geneontology.org/formats/oboInOwl#hasAlternativeId) "GO:0106311" -- [neuron projection bundle](http://purl.obolibrary.org/obo/CARO_0001001) [IAO_0000118](http://purl.obolibrary.org/obo/IAO_0000118) "nerve fiber bundle" - - [IAO_scope](http://purl.obolibrary.org/obo/IAO_scope) "EXACT" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-442739" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "PDPK1 phosphorylates RSKs" -- Class: [neuron projection bundle](http://purl.obolibrary.org/obo/CARO_0001001) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-198731" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "ERK1/2 activates ELK1" -- [neuron projection bundle](http://purl.obolibrary.org/obo/CARO_0001001) SubClassOf [bearer of](http://purl.obolibrary.org/obo/RO_0000053) some [fiber shaped](http://purl.obolibrary.org/obo/PATO_0002309) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-5671763" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "p-T774-PKN1 phosphorylates PPP1R14A" -- [neuron projection bundle](http://purl.obolibrary.org/obo/CARO_0001001) SubClassOf [multi-cell-part structure](http://purl.obolibrary.org/obo/CARO_0001000) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-6799409" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "HIPK2 phosphorylates TP53" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-202510" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Activation of TAK1-TAB2 complex" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-5218821" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "PDK1 phosphorylates PKC" -### neuronal acetylcholine receptor subunit alpha-7 `http://purl.obolibrary.org/obo/PR_000005460` +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-3772435" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "WNT signaling stimulates CSNK1-dependent phosphorylation of DVL" -#### Added -- [neuronal acetylcholine receptor subunit alpha-7](http://purl.obolibrary.org/obo/PR_000005460) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [neuronal acetylcholine receptor subunit alpha-7 (human)](http://purl.obolibrary.org/obo/PR_P36544) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-399951" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Phosphorylation of CRMPs by GSK3beta" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-3769394" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "AKT phosphorylates CBY1" -### neuropilin and tolloid-like protein 1 `http://purl.obolibrary.org/obo/PR_000011143` +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-5685242" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "CHEK1 phosphorylates BRCA2" -#### Added -- [neuropilin and tolloid-like protein 1](http://purl.obolibrary.org/obo/PR_000011143) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [neuropilin and tolloid-like protein 1 (human)](http://purl.obolibrary.org/obo/PR_Q8TDF5) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-164151" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "LKB1 phosphorylates the alpha subunit of AMPK heterotrimer" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-2243938" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "AKT1 E17K mutant is phosphorylated by TORC2 complex" -### neuroplacodal cell `http://purl.obolibrary.org/obo/CL_0000032` -#### Removed -- [neuroplacodal cell](http://purl.obolibrary.org/obo/CL_0000032) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-69604" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Phosphorylation of Cdc25A at Ser-123 by Chk1" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-419087" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "LIM kinase phosphorylation by ROCK" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-2028635" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Phosphorylation of MOB1A and B by p-STK3 (p-MST2)" -### neurula embryo `http://purl.obolibrary.org/obo/UBERON_0004455` -#### Removed -- [neurula embryo](http://purl.obolibrary.org/obo/UBERON_0004455) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-5687094" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "p-S MAPK6,4 phosphorylate MAPKAPK5" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-5693549" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "ATM phosphorylates histone H2AFX on S139 at DNA DSBs" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-4551570" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "VANGL2 is phosphorylated in response to WNT5A" -### neurula stage `http://purl.obolibrary.org/obo/UBERON_0000110` +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-6788392" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA" -#### Added -- [neurula stage](http://purl.obolibrary.org/obo/UBERON_0000110) [UBPROP_0000008](http://purl.obolibrary.org/obo/UBPROP_0000008) "In zebrafish, the times of neurulation and segmentation overlap so extensively there is no distinct neurula period of development, such as occurs largely before segmentation in amphibian embryos." +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-5683425" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "ATM phosphorylates TP53BP1 at DNA DSBs" -- [neurula stage](http://purl.obolibrary.org/obo/UBERON_0000110) [see also](http://www.w3.org/2000/01/rdf-schema#seeAlso) "https://github.com/obophenotype/developmental-stage-ontologies/issues/84"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-975180" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9" -- [neurula stage](http://purl.obolibrary.org/obo/UBERON_0000110) [RO_0002174](http://purl.obolibrary.org/obo/RO_0002174) [NCBITaxon_7955](http://purl.obolibrary.org/obo/NCBITaxon_7955) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-1181355" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Phosphorylation of R-SMAD2/3 by NODAL receptor" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-75028" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Phosphorylation of Wee1 kinase by Chk1" -### neutrophil gelatinase-associated lipocalin `http://purl.obolibrary.org/obo/PR_000009725` +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-2029460" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "PAK1 phosphorylates LIMK1" -#### Added -- [neutrophil gelatinase-associated lipocalin](http://purl.obolibrary.org/obo/PR_000009725) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [neutrophil gelatinase-associated lipocalin (human)](http://purl.obolibrary.org/obo/PR_P80188) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-199299" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "AKT phosphorylates FOXO transcription factors" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-199298" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "AKT phosphorylates CREB1" -### non-classical monocyte `http://purl.obolibrary.org/obo/CL_0000875` -#### Removed -- [non-classical monocyte](http://purl.obolibrary.org/obo/CL_0000875) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [term tracker item](http://purl.obolibrary.org/obo/IAO_0000233) "https://github.com/geneontology/go-ontology/issues/20114"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-3928625" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "PAKs autophosphorylate" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-6802926" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Mutant RAS:p-RAF complexes phosphorylate MAP2Ks" -### non-medulla, extratelencephalic-projecting glutamatergic neuron of the primary motor cortex `http://purl.obolibrary.org/obo/CL_4023044` +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-209087" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "IKBA is phosphorylated by Phospho IKKB kinase" -#### Added -- [non-medulla, extratelencephalic-projecting glutamatergic neuron of the primary motor cortex](http://purl.obolibrary.org/obo/CL_4023044) [symbol](http://purl.obolibrary.org/obo/IAO_0000028) "non-MY ET glut MOp" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-5672008" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Thr-180 of ULK1 is phosphorylated" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-5672973" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "MAP2Ks phosphorylate MAPKs" -### non-secretory ribonuclease `http://purl.obolibrary.org/obo/PR_000014046` +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-389756" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "AKT interacts and phosphorylates Cot" -#### Added -- [non-secretory ribonuclease](http://purl.obolibrary.org/obo/PR_000014046) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [non-secretory ribonuclease (human)](http://purl.obolibrary.org/obo/PR_P10153) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-3239014" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "MAPKAPK5 phosphorylates TP53" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-5692768" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "MAPKAPK5 phosphorylates KALRN" -### notochordal cell `http://purl.obolibrary.org/obo/CL_0007005` -#### Removed -- [notochordal cell](http://purl.obolibrary.org/obo/CL_0007005) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-2029454" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Autophosphorylation of PAK1" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-1168635" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "PRKCB (PKC-beta) phosphorylates CARMA1" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-975865" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "IRAK4 autophosphorylation within the complex activated TLR:MyD88" -### notochordal process `http://purl.obolibrary.org/obo/UBERON_0006268` -#### Removed -- [notochordal process](http://purl.obolibrary.org/obo/UBERON_0006268) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-195318" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Phosphorylation of beta-catenin at Ser45 by CK1 alpha" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-8853444" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "AURKA phosphorylates PHLDA1" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-5632672" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "ADRBK1 phosphorylates SMO dimer" -### nuclear factor NF-kappa-B p100 subunit `http://purl.obolibrary.org/obo/PR_000011178` +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-8868573" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "CDK5:p25 phosphorylates PRDX2" -#### Added -- [nuclear factor NF-kappa-B p100 subunit](http://purl.obolibrary.org/obo/PR_000011178) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [nuclear factor NF-kappa-B p100 subunit (human)](http://purl.obolibrary.org/obo/PR_Q00653) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-450337" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Activated TAK1 phosphorylates MKK4/MKK7" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-428961" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Phosphorylation of cPLA2 by MAPK p38 alpha" -### nuclear receptor ROR-gamma `http://purl.obolibrary.org/obo/PR_000001902` +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-69608" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Phosphorylation of Cdc25A at Ser-123 by Chk2" -#### Added -- [nuclear receptor ROR-gamma](http://purl.obolibrary.org/obo/PR_000001902) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [nuclear receptor ROR-gamma (human)](http://purl.obolibrary.org/obo/PR_P51449) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-6795290" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "TORC2 complex phosphorylates SGK1" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-5357472" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "PAK1-3 autophosphorylates" -### obsolescence reason specification `http://purl.obolibrary.org/obo/IAO_0000225` +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-9729300" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Unknown kinase phosphorylates nucleoprotein" -#### Added -- [obsolescence reason specification](http://purl.obolibrary.org/obo/IAO_0000225) [IAO_0000117](http://purl.obolibrary.org/obo/IAO_0000117) "PERSON: Melanie Courtot"@en +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-6804266" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "CHEK2 phosphorylates TTC5" -- [obsolescence reason specification](http://purl.obolibrary.org/obo/IAO_0000225) [IAO_0000117](http://purl.obolibrary.org/obo/IAO_0000117) "PERSON: Alan Ruttenberg"@en +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-156673" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Regulation of KIF23 (MKLP1) by phosphorylation" -- [obsolescence reason specification](http://purl.obolibrary.org/obo/IAO_0000225) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The reason for which a term has been deprecated. The allowed values come from an enumerated list of predefined terms. See the specification of these instances for more detailed definitions of each enumerated value."@en +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-9007539" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "CHEK1 phosphorylates E2F6" -- [obsolescence reason specification](http://purl.obolibrary.org/obo/IAO_0000225) [label](http://www.w3.org/2000/01/rdf-schema#label) "obsolescence reason specification"@en +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-5683792" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "p-T68-CHEK2 autophosphorylates" -- [obsolescence reason specification](http://purl.obolibrary.org/obo/IAO_0000225) [IAO_0000114](http://purl.obolibrary.org/obo/IAO_0000114) [pending final vetting](http://purl.obolibrary.org/obo/IAO_0000125) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-3928616" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Activated ROCK phosphorylates MRLCs" -- [obsolescence reason specification](http://purl.obolibrary.org/obo/IAO_0000225) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "obsolescence reason specification"@en +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-5260201" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "p-AKT2 phosphorylates C2CD5" -- [obsolescence reason specification](http://purl.obolibrary.org/obo/IAO_0000225) [editor note](http://purl.obolibrary.org/obo/IAO_0000116) "The creation of this class has been inspired in part by Werner Ceusters' paper, Applying evolutionary terminology auditing to the Gene Ontology."@en +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-445072" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Interaction of PAK1 with Rac1-GTP" -- Class: [obsolescence reason specification](http://purl.obolibrary.org/obo/IAO_0000225) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-5672948" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "MARK3 phosphorylates KSR1" -- [obsolescence reason specification](http://purl.obolibrary.org/obo/IAO_0000225) EquivalentTo {[failed exploratory term](http://purl.obolibrary.org/obo/IAO_0000103) , [placeholder removed](http://purl.obolibrary.org/obo/IAO_0000226) , [terms merged](http://purl.obolibrary.org/obo/IAO_0000227) , [term imported](http://purl.obolibrary.org/obo/IAO_0000228) , [term split](http://purl.obolibrary.org/obo/IAO_0000229) , [OMO_0001000](http://purl.obolibrary.org/obo/OMO_0001000)} +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-9773803" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Active IKBKB phosphorylates NF-kappa-B inhibitor" -- [obsolescence reason specification](http://purl.obolibrary.org/obo/IAO_0000225) SubClassOf [data about an ontology part](http://purl.obolibrary.org/obo/IAO_0000102) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-8868340" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "CDK5:p25 phosphorylates lamin B1" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-109862" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "MAP2K2 phosphorylates MAPK1" -### occurs across `http://purl.obolibrary.org/obo/RO_0002021` -#### Removed -- [occurs across](http://purl.obolibrary.org/obo/RO_0002021) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "dos" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-5668947" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "PAK1 phosphorylates myosin phosphatase" -#### Added -- [occurs across](http://purl.obolibrary.org/obo/RO_0002021) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) [0000-0002-7073-9172](https://orcid.org/0000-0002-7073-9172) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-109702" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "PDPK1 phosphorylates AKT2" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-5693598" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "ATM phosphorylates NBN" -### occurs in `http://purl.obolibrary.org/obo/BFO_0000066` +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-8870558" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "CDK5:p25 phosphorylates FOXO3" -#### Added -- [occurs in](http://purl.obolibrary.org/obo/BFO_0000066) [see also](http://www.w3.org/2000/01/rdf-schema#seeAlso) "https://wiki.geneontology.org/Occurs_in"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-5228811" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "NFKBIA variant is not phosphorylated within IkBA:NF-kappaB" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-6802943" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "RAS:GTP:inactive p-RAF complexes phosphorylate MAP2Ks" -### octopus cell of the mammalian cochlear nucleus `http://purl.obolibrary.org/obo/CL_4023158` -#### Removed -- [octopus cell of the mammalian cochlear nucleus](http://purl.obolibrary.org/obo/CL_4023158) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-5635841" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "GLI proteins are phosphorylated" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-2028583" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Phosphorylation of YAP by LATS2" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "serine protein kinase activity" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "EC:2.7.11.1" -### odontocyte `http://purl.obolibrary.org/obo/CL_0000140` -#### Removed -- [odontocyte](http://purl.obolibrary.org/obo/CL_0000140) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-4411383" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "NLK phosphorylates TCF/LEF" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-5624473" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Protein kinase A (PKA) and RPS6KA5 (MSK1) phosphorylates p65 (RELA) subunit" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-4411402" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Activation of NLK" -### olfactory bulb interneuron `http://purl.obolibrary.org/obo/CL_1001434` -#### Removed -- [olfactory bulb interneuron](http://purl.obolibrary.org/obo/CL_1001434) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-1358791" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Phosphorylation of USP8 by P-AKT" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-913996" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "PKA/PKG phosphorylate Rap1GAP2" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-200143" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "AKT phosphorylates AKT1S1 (PRAS40)" -### olfactory bulb tufted cell `http://purl.obolibrary.org/obo/CL_1001503` -#### Removed -- [olfactory bulb tufted cell](http://purl.obolibrary.org/obo/CL_1001503) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-5675194" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Activated MAPK phosphorylates RAF1" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-8868118" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "MAPK12 phosphorylates PTPN3" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-8933446" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling" -### olfactory nerve `http://purl.obolibrary.org/obo/UBERON_0001579` -#### Removed -- [olfactory nerve](http://purl.obolibrary.org/obo/UBERON_0001579) SubClassOf [neuron projection bundle](http://purl.obolibrary.org/obo/CARO_0001001) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-168184" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Activated TAK1 mediates phosphorylation of the IKK Complex" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-5357477" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "PAK1-3 phosphorylates VE-cadherin" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-1454699" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "AMPK-alpha2 phosphorylates TBC1D1" -### olfactory pit `http://purl.obolibrary.org/obo/UBERON_0005870` -#### Removed -- [olfactory pit](http://purl.obolibrary.org/obo/UBERON_0005870) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-5082405" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Phosphorylation of HSF1 at Ser326 induces transactivation" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-380272" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Plk1-mediated phosphorylation of Nlp" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-4608825" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "DVL2 is phosphorylated after WNT5A binding to FZD" -### olfactory segment of nasal mucosa `http://purl.obolibrary.org/obo/UBERON_0005386` -#### Removed -- [olfactory segment of nasal mucosa](http://purl.obolibrary.org/obo/UBERON_0005386) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-198669" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "p38MAPK phosphorylates MSK1" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-8868344" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "CDK5:p25 phosphorylates lamin A" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-1638803" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Phosphorylation of cohesin by PLK1 at centromeres" -### oogonial cell `http://purl.obolibrary.org/obo/CL_0000024` -#### Removed -- [oogonial cell](http://purl.obolibrary.org/obo/CL_0000024) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-5218906" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "RIPK3 phosphorylates MLKL" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-2028673" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Phosphorylation of LATS1 and 2 by p-STK3 (MST2)/N" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-975125" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9" -### ophthalmic nerve `http://purl.obolibrary.org/obo/UBERON_0000348` -#### Removed -- [ophthalmic nerve](http://purl.obolibrary.org/obo/UBERON_0000348) SubClassOf [neuron projection bundle](http://purl.obolibrary.org/obo/CARO_0001001) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-176116" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Recruitment and activation of Chk1" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-5607722" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Active NIK phosphorylates IKKA dimer" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-2730900" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Activation of TAK1 complex bound to pUb-TRAF6" -### optic cup `http://purl.obolibrary.org/obo/UBERON_0003072` -#### Removed -- [optic cup](http://purl.obolibrary.org/obo/UBERON_0003072) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-1181156" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Type II Activin Receptor (ActRII/ACVR2) phosphorylates Type I Activin Receptor (ActRIB/ACVR1B) in response to NODAL" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-377186" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Activated Akt1 phosphorylates AKT1S1 (PRAS40)" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-9023132" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "AURKB phosphorylates MECP2 at S423" -### optic tract `http://purl.obolibrary.org/obo/UBERON_0001908` -#### Removed -- [optic tract](http://purl.obolibrary.org/obo/UBERON_0001908) SubClassOf [neuron projection bundle](http://purl.obolibrary.org/obo/CARO_0001001) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-975861" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomerl:activated TLR5 or 10 complex" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-165726" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Phosphorylation of Ribosomal protein S6 by activated S6K1" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-3928577" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "ROCK phosphorylates LIMK1,2" -### optic vesicle `http://purl.obolibrary.org/obo/UBERON_0004128` -#### Removed -- [optic vesicle](http://purl.obolibrary.org/obo/UBERON_0004128) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-9705320" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "TBK1, IKBKE are autophosphorylated at Ser172" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-5357831" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "CHUK, IKBKB phosphorylate CYLD at S418" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-109860" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "MAP2K1 phosphorylates MAPK3" -### organizational term `http://purl.obolibrary.org/obo/IAO_0000121` +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-6802911" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "High kinase activity BRAF complexes phosphorylate MAP2Ks" -#### Added -- [organizational term](http://purl.obolibrary.org/obo/IAO_0000121) [label](http://www.w3.org/2000/01/rdf-schema#label) "organizational term"@en +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-9648883" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "p-T-EIF2AK1:ferriheme dimer autophosphorylates" -- [organizational term](http://purl.obolibrary.org/obo/IAO_0000121) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "organizational term"@en +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-3928608" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "LIMK phosphorylates CFL1, inactivating it" -- [organizational term](http://purl.obolibrary.org/obo/IAO_0000121) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Term created to ease viewing/sort terms for development purpose, and will not be included in a release"@en +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-9645535" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "ALPK1 phosphorylates TIFA" -- Individual: [organizational term](http://purl.obolibrary.org/obo/IAO_0000121) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-165718" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "mTORC1 phosphorylation of RPS6KB1 (S6K)" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-1445144" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4)" -### organogenesis stage `http://purl.obolibrary.org/obo/UBERON_0000111` -#### Removed -- [organogenesis stage](http://purl.obolibrary.org/obo/UBERON_0000111) SubClassOf [preceded by](http://purl.obolibrary.org/obo/BFO_0000062) some [neurula stage](http://purl.obolibrary.org/obo/UBERON_0000110) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-3371435" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Constitutive phosphorylation by GSK3" -#### Added -- [organogenesis stage](http://purl.obolibrary.org/obo/UBERON_0000111) [see also](http://www.w3.org/2000/01/rdf-schema#seeAlso) "https://github.com/obophenotype/developmental-stage-ontologies/issues/84"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-6805059" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "CK2:FACT phosphorylates TP53" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-5679205" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "ULK1 phosphorylates Beclin-1" -### osteoclast `http://purl.obolibrary.org/obo/CL_0000092` -#### Removed -- [osteoclast](http://purl.obolibrary.org/obo/CL_0000092) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-419197" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Myosin regulatory light chain phosphorylation by ROCK" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-5668932" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "PAK2 phosphorylates myosin regulatory light chain (MRLC)" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [has_alternative_id](http://www.geneontology.org/formats/oboInOwl#hasAlternativeId) "GO:0004695" -### osteocyte `http://purl.obolibrary.org/obo/CL_0000137` -#### Removed -- [osteocyte](http://purl.obolibrary.org/obo/CL_0000137) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-9613530" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "PRKAA2 phosphorylates PLINs" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-9815501" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "MAPKAPK2 phosphorylates RIPK1 at S320" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-166119" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal" -### otic pit `http://purl.obolibrary.org/obo/UBERON_0006273` -#### Removed -- [otic pit](http://purl.obolibrary.org/obo/UBERON_0006273) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-3928640" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "PAKs phosphorylate MLC" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-5694441" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "CSNK1D phosphorylates SEC23" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-3000327" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "PLK1 phosphorylates BORA" -### otocyst lumen `http://purl.obolibrary.org/obo/UBERON_0013526` -#### Removed -- [otocyst lumen](http://purl.obolibrary.org/obo/UBERON_0013526) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-3371567" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "DBC1 is phosphorylated by ATM/ART" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-202222" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Phosphorylation of PKC theta" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-5666160" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "AURKB phosphorylates DIAPH2-2 at kinetochores" -### outer epithelium `http://purl.obolibrary.org/obo/UBERON_0007376` -#### Removed -- [outer epithelium](http://purl.obolibrary.org/obo/UBERON_0007376) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-111970" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "PKC phosphorylates GRK2" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-75809" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Phosphorylation of Cdc25C at Ser216 by CHEK2" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-168140" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Active IKK Complex phosphorylates NF-kappa-B inhibitor" -### outflow part of right ventricle `http://purl.obolibrary.org/obo/UBERON_0005953` -#### Removed -- [outflow part of right ventricle](http://purl.obolibrary.org/obo/UBERON_0005953) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-9652165" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "MAP2K mutants constitutively phosphorylate MAPKs" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-166284" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:TIRAP" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-156682" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "PLK1 phosphorylates NUDC" -### ovary stroma `http://purl.obolibrary.org/obo/UBERON_0006960` -#### Removed -- [ovary stroma](http://purl.obolibrary.org/obo/UBERON_0006960) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-5675198" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Activated MAPKs phosphorylate BRAF" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-399944" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Phosphorylation of CRMPs by Cdk5" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-198270" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "PDPK1 phosphorylates AKT at T308" -### oxytocin receptor `http://purl.obolibrary.org/obo/PR_000001635` +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-2168079" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "MASTL (GWL) phosphorylates ARPP19" -#### Added -- [oxytocin receptor](http://purl.obolibrary.org/obo/PR_000001635) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [oxytocin receptor (human)](http://purl.obolibrary.org/obo/PR_P30559) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-9653503" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "KRAS4B is phosphorylated on serine 181" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-392752" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Phosphorylation of L1 by CK-II" -### pair of lungs `http://purl.obolibrary.org/obo/UBERON_0000170` -#### Removed -- [pair of lungs](http://purl.obolibrary.org/obo/UBERON_0000170) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-1362270" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Phosphorylation of LIN52 component of MuvB by DYRK1A" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-198609" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "AKT phosphorylates TSC2, inhibiting it" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-5687090" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "p-S MAPK6 phosphorylates NCOA3" -### paired box protein PAX-5 `http://purl.obolibrary.org/obo/PR_000001903` +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-2028589" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2)" -#### Added -- [paired box protein PAX-5](http://purl.obolibrary.org/obo/PR_000001903) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [paired box protein Pax-5 (human)](http://purl.obolibrary.org/obo/PR_Q02548) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-9662823" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "PLK2, MAPK14 phosphorylate ADAM17" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "serine-specific protein kinase activity" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "EC:2.7.11.1" -### paired limb/fin `http://purl.obolibrary.org/obo/UBERON_0004708` -#### Removed -- [paired limb/fin](http://purl.obolibrary.org/obo/UBERON_0004708) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-9819106" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "ULK1 phosphorylates RIPK1 at S357" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-6801666" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "PLK2 phosphorylates CENPJ" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-8868567" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "CDK5:p25 phosphorylates PRDX1" -### paired limb/fin bud `http://purl.obolibrary.org/obo/UBERON_0004357` -#### Removed -- [paired limb/fin bud](http://purl.obolibrary.org/obo/UBERON_0004357) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-2984258" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "NEK9 phosphorylates NEK6/NEK7" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-9612980" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "BRAF in Rap1-GTP complex:BRAF complex autophosphorylates" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-2399996" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "AKT1 E17K mutant phosphorylates CREB1" -### paired limb/fin field `http://purl.obolibrary.org/obo/UBERON_0005732` -#### Removed -- [paired limb/fin field](http://purl.obolibrary.org/obo/UBERON_0005732) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-9610156" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-156723" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Regulation of KIF20A (MKL2) by phosphorylation" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-165162" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Phosphorylation of TSC2 by PKB" -### paired limb/fin skeleton `http://purl.obolibrary.org/obo/UBERON_0011582` -#### Removed -- [paired limb/fin skeleton](http://purl.obolibrary.org/obo/UBERON_0011582) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-349444" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Phosphorylation of COP1 at Ser-387 by ATM" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-199863" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "AKT can phosphorylate NR4A1 (NUR77)" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-1168641" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "TAK1 associated with the CBM complex phosphorylates IKKbeta" -### palatoquadrate arch `http://purl.obolibrary.org/obo/UBERON_0011085` -#### Removed -- [palatoquadrate arch](http://purl.obolibrary.org/obo/UBERON_0011085) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-9758486" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "Unknown kinase phosphorylates 9b" +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-934559" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "SPRY2 is phosphorylated by phosphorylated MNK1" +- Class: [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) -### pancreatic acinus `http://purl.obolibrary.org/obo/UBERON_0001263` -#### Removed -- [pancreatic acinus](http://purl.obolibrary.org/obo/UBERON_0001263) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) SubClassOf [protein kinase activity](http://purl.obolibrary.org/obo/GO_0004672) -### pancreatic lobule `http://purl.obolibrary.org/obo/UBERON_0007324` -#### Removed -- [pancreatic lobule](http://purl.obolibrary.org/obo/UBERON_0007324) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +### protein transmembrane import into intracellular organelle `http://purl.obolibrary.org/obo/GO_0044743` +#### Added +- [protein transmembrane import into intracellular organelle](http://purl.obolibrary.org/obo/GO_0044743) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "jl" +- [protein transmembrane import into intracellular organelle](http://purl.obolibrary.org/obo/GO_0044743) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2012-11-07T15:37:36Z" -### papillary layer of dermis `http://purl.obolibrary.org/obo/UBERON_0001992` -#### Removed -- [papillary layer of dermis](http://purl.obolibrary.org/obo/UBERON_0001992) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [protein transmembrane import into intracellular organelle](http://purl.obolibrary.org/obo/GO_0044743) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The directed movement of proteins into an intracellular organelle, across a membrane." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:jl" +- [protein transmembrane import into intracellular organelle](http://purl.obolibrary.org/obo/GO_0044743) [label](http://www.w3.org/2000/01/rdf-schema#label) "protein transmembrane import into intracellular organelle" +- [protein transmembrane import into intracellular organelle](http://purl.obolibrary.org/obo/GO_0044743) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0044743" -### parafollicular cell `http://purl.obolibrary.org/obo/CL_0000570` -#### Removed -- [parafollicular cell](http://purl.obolibrary.org/obo/CL_0000570) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [protein transmembrane import into intracellular organelle](http://purl.obolibrary.org/obo/GO_0044743) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" +- Class: [protein transmembrane import into intracellular organelle](http://purl.obolibrary.org/obo/GO_0044743) +- [protein transmembrane import into intracellular organelle](http://purl.obolibrary.org/obo/GO_0044743) EquivalentTo [transport](http://purl.obolibrary.org/obo/GO_0006810) and ([has target start location](http://purl.obolibrary.org/obo/RO_0002338) some [cytosol](http://purl.obolibrary.org/obo/GO_0005829)) and ([has target end location](http://purl.obolibrary.org/obo/RO_0002339) some [intracellular organelle](http://purl.obolibrary.org/obo/GO_0043229)) and ([results in transport across](http://purl.obolibrary.org/obo/RO_0002342) some [organelle membrane](http://purl.obolibrary.org/obo/GO_0031090)) and ([has primary input](http://purl.obolibrary.org/obo/RO_0004009) some [protein](http://purl.obolibrary.org/obo/PR_000000001)) -### parasympathetic nerve `http://purl.obolibrary.org/obo/UBERON_0004293` -#### Removed -- [parasympathetic nerve](http://purl.obolibrary.org/obo/UBERON_0004293) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [protein transmembrane import into intracellular organelle](http://purl.obolibrary.org/obo/GO_0044743) SubClassOf [establishment of protein localization to organelle](http://purl.obolibrary.org/obo/GO_0072594) +- [protein transmembrane import into intracellular organelle](http://purl.obolibrary.org/obo/GO_0044743) SubClassOf [has target start location](http://purl.obolibrary.org/obo/RO_0002338) some [cytosol](http://purl.obolibrary.org/obo/GO_0005829) +- [protein transmembrane import into intracellular organelle](http://purl.obolibrary.org/obo/GO_0044743) SubClassOf [results in transport across](http://purl.obolibrary.org/obo/RO_0002342) some [organelle membrane](http://purl.obolibrary.org/obo/GO_0031090) -### parenchyma of parathyroid gland `http://purl.obolibrary.org/obo/UBERON_0001749` -#### Removed -- [parenchyma of parathyroid gland](http://purl.obolibrary.org/obo/UBERON_0001749) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [protein transmembrane import into intracellular organelle](http://purl.obolibrary.org/obo/GO_0044743) SubClassOf [has target end location](http://purl.obolibrary.org/obo/RO_0002339) some [intracellular organelle](http://purl.obolibrary.org/obo/GO_0043229) +- [protein transmembrane import into intracellular organelle](http://purl.obolibrary.org/obo/GO_0044743) SubClassOf [protein transmembrane transport](http://purl.obolibrary.org/obo/GO_0071806) -### parenchyma of thyroid gland `http://purl.obolibrary.org/obo/UBERON_0001747` +### protein-phosphatidylethanolamide deconjugating activity `http://purl.obolibrary.org/obo/GO_0019786` #### Removed -- [parenchyma of thyroid gland](http://purl.obolibrary.org/obo/UBERON_0001747) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) - +- [protein-phosphatidylethanolamide deconjugating activity](http://purl.obolibrary.org/obo/GO_0019786) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Catalysis of the reaction: [protein]-C-terminal L-amino acid-glycyl-phosphatidylethanolamide + H2O = [protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine. An example of this reaction is the removal of ATG8 from membranes to which it is covalently linked to a phosphatidylethanolamid via its terminal glycine residue." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:28330855" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:22240591" -### parietal peritoneum `http://purl.obolibrary.org/obo/UBERON_0001366` -#### Removed -- [parietal peritoneum](http://purl.obolibrary.org/obo/UBERON_0001366) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000) + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:2882172" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:22652539" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:28901328" -### parietal pleura `http://purl.obolibrary.org/obo/UBERON_0002400` -#### Removed -- [parietal pleura](http://purl.obolibrary.org/obo/UBERON_0002400) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000) +- [protein-phosphatidylethanolamide deconjugating activity](http://purl.obolibrary.org/obo/GO_0019786) [term tracker item](http://purl.obolibrary.org/obo/IAO_0000233) "https://github.com/geneontology/go-ontology/issues/25472"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI) +- [protein-phosphatidylethanolamide deconjugating activity](http://purl.obolibrary.org/obo/GO_0019786) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "ATG8-PE hydrolase activity" + - [source](http://www.geneontology.org/formats/oboInOwl#source) "skos:narrowMatch" +- [protein-phosphatidylethanolamide deconjugating activity](http://purl.obolibrary.org/obo/GO_0019786) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "ATG8-PE deconjugation activity" + - [source](http://www.geneontology.org/formats/oboInOwl#source) "skos:narrowMatch" -### part_of `http://purl.obolibrary.org/obo/BFO_0000050` +- [protein-phosphatidylethanolamide deconjugating activity](http://purl.obolibrary.org/obo/GO_0019786) [label](http://www.w3.org/2000/01/rdf-schema#label) "protein-phosphatidylethanolamide deconjugating activity" -#### Added -- [part_of](http://purl.obolibrary.org/obo/BFO_0000050) [see also](http://www.w3.org/2000/01/rdf-schema#seeAlso) "https://wiki.geneontology.org/Part_of"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI) +- [protein-phosphatidylethanolamide deconjugating activity](http://purl.obolibrary.org/obo/GO_0019786) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0019786" +- [protein-phosphatidylethanolamide deconjugating activity](http://purl.obolibrary.org/obo/GO_0019786) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "Atg8-specific protease activity" + - [source](http://www.geneontology.org/formats/oboInOwl#source) "skos:narrowMatch" -### parvalbumin alpha `http://purl.obolibrary.org/obo/PR_000013502` +- [protein-phosphatidylethanolamide deconjugating activity](http://purl.obolibrary.org/obo/GO_0019786) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "APG8-PE hydrolase" + - [source](http://www.geneontology.org/formats/oboInOwl#source) "skos:narrowMatch" -#### Added -- [parvalbumin alpha](http://purl.obolibrary.org/obo/PR_000013502) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [parvalbumin alpha (human)](http://purl.obolibrary.org/obo/PR_P20472) +- [protein-phosphatidylethanolamide deconjugating activity](http://purl.obolibrary.org/obo/GO_0019786) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "molecular_function" +- [protein-phosphatidylethanolamide deconjugating activity](http://purl.obolibrary.org/obo/GO_0019786) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "Atg8-specific peptidase activity" + - [source](http://www.geneontology.org/formats/oboInOwl#source) "skos:narrowMatch" -### parvocellular layer of dorsal nucleus of lateral geniculate body `http://purl.obolibrary.org/obo/UBERON_0013607` -#### Removed -- [parvocellular layer of dorsal nucleus of lateral geniculate body](http://purl.obolibrary.org/obo/UBERON_0013607) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [protein-phosphatidylethanolamide deconjugating activity](http://purl.obolibrary.org/obo/GO_0019786) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "APG8-specific protease activity" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:vw" +- Class: [protein-phosphatidylethanolamide deconjugating activity](http://purl.obolibrary.org/obo/GO_0019786) +- [protein-phosphatidylethanolamide deconjugating activity](http://purl.obolibrary.org/obo/GO_0019786) SubClassOf [hydrolase activity](http://purl.obolibrary.org/obo/GO_0016787) -### pectoral appendage bud ectoderm `http://purl.obolibrary.org/obo/UBERON_0003372` -#### Removed -- [pectoral appendage bud ectoderm](http://purl.obolibrary.org/obo/UBERON_0003372) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [protein-phosphatidylethanolamide deconjugating activity](http://purl.obolibrary.org/obo/GO_0019786) SubClassOf [catalytic activity, acting on a protein](http://purl.obolibrary.org/obo/GO_0140096) -### pectoral complex `http://purl.obolibrary.org/obo/UBERON_0010708` +### pulmonary acinus `http://purl.obolibrary.org/obo/UBERON_0008874` #### Removed -- [pectoral complex](http://purl.obolibrary.org/obo/UBERON_0010708) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000) - +- [pulmonary acinus](http://purl.obolibrary.org/obo/UBERON_0008874) SubClassOf [pulmonary lobule](http://purl.obolibrary.org/obo/UBERON_0010368) + - [source](http://www.geneontology.org/formats/oboInOwl#source) "FMA" +#### Added +- [pulmonary acinus](http://purl.obolibrary.org/obo/UBERON_0008874) SubClassOf [independent continuant](http://purl.obolibrary.org/obo/BFO_0000004) -### pedal digit epithelium `http://purl.obolibrary.org/obo/UBERON_0005226` -#### Removed -- [pedal digit epithelium](http://purl.obolibrary.org/obo/UBERON_0005226) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [pulmonary acinus](http://purl.obolibrary.org/obo/UBERON_0008874) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [secondary pulmonary lobule](http://purl.obolibrary.org/obo/UBERON_0010369) +- [pulmonary acinus](http://purl.obolibrary.org/obo/UBERON_0008874) SubClassOf [connected to](http://purl.obolibrary.org/obo/RO_0002170) some [terminal bronchiole](http://purl.obolibrary.org/obo/UBERON_0002187) -### pedal digit mesenchyme `http://purl.obolibrary.org/obo/UBERON_0005255` -#### Removed -- [pedal digit mesenchyme](http://purl.obolibrary.org/obo/UBERON_0005255) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +### pulmonary alveolar parenchyma `http://purl.obolibrary.org/obo/UBERON_0008870` +#### Added +- [pulmonary alveolar parenchyma](http://purl.obolibrary.org/obo/UBERON_0008870) [contributor](http://purl.org/dc/terms/contributor) [0000-0001-6677-8489](https://orcid.org/0000-0001-6677-8489) +- [pulmonary alveolar parenchyma](http://purl.obolibrary.org/obo/UBERON_0008870) SubClassOf [has part](http://purl.obolibrary.org/obo/BFO_0000051) some [type I pneumocyte](http://purl.obolibrary.org/obo/CL_0002062) -### pelvic appendage bud ectoderm `http://purl.obolibrary.org/obo/UBERON_0003371` -#### Removed -- [pelvic appendage bud ectoderm](http://purl.obolibrary.org/obo/UBERON_0003371) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [pulmonary alveolar parenchyma](http://purl.obolibrary.org/obo/UBERON_0008870) SubClassOf [has part](http://purl.obolibrary.org/obo/BFO_0000051) some [type II pneumocyte](http://purl.obolibrary.org/obo/CL_0002063) +- [pulmonary alveolar parenchyma](http://purl.obolibrary.org/obo/UBERON_0008870) SubClassOf [has part](http://purl.obolibrary.org/obo/BFO_0000051) some [lung pericyte](http://purl.obolibrary.org/obo/CL_0009089) -### pelvic complex `http://purl.obolibrary.org/obo/UBERON_0010709` +### pulmonary lobule `http://purl.obolibrary.org/obo/UBERON_0010368` #### Removed -- [pelvic complex](http://purl.obolibrary.org/obo/UBERON_0010709) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000) +- [pulmonary lobule](http://purl.obolibrary.org/obo/UBERON_0010368) SubClassOf [has part](http://purl.obolibrary.org/obo/BFO_0000051) some [terminal bronchiole](http://purl.obolibrary.org/obo/UBERON_0002187) +- [pulmonary lobule](http://purl.obolibrary.org/obo/UBERON_0010368) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [lung](http://purl.obolibrary.org/obo/UBERON_0002048) +- [pulmonary lobule](http://purl.obolibrary.org/obo/UBERON_0010368) SubClassOf [protein-containing material entity](http://purl.obolibrary.org/obo/PR_000050567) -### pelvic region of trunk `http://purl.obolibrary.org/obo/UBERON_0002355` -#### Removed -- [pelvic region of trunk](http://purl.obolibrary.org/obo/UBERON_0002355) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +#### Added +- [pulmonary lobule](http://purl.obolibrary.org/obo/UBERON_0010368) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [bronchopulmonary segment](http://purl.obolibrary.org/obo/UBERON_8600017) +### pyrophosphatase activity `http://purl.obolibrary.org/obo/GO_0016462` +#### Removed +- [pyrophosphatase activity](http://purl.obolibrary.org/obo/GO_0016462) [label](http://www.w3.org/2000/01/rdf-schema#label) "pyrophosphatase activity" -### pending final vetting `http://purl.obolibrary.org/obo/IAO_0000125` +- [pyrophosphatase activity](http://purl.obolibrary.org/obo/GO_0016462) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0016462" -#### Added -- [pending final vetting](http://purl.obolibrary.org/obo/IAO_0000125) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "All definitions, placement in the asserted IS_A hierarchy and required minimal metadata are complete. The class is awaiting a final review by someone other than the term editor."@en +- [pyrophosphatase activity](http://purl.obolibrary.org/obo/GO_0016462) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Catalysis of the hydrolysis of a pyrophosphate bond (diphosphate bond) between two phosphate groups." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:curators" -- [pending final vetting](http://purl.obolibrary.org/obo/IAO_0000125) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "pending final vetting"@en + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "https://en.wikipedia.org/wiki/Pyrophosphatase" -- [pending final vetting](http://purl.obolibrary.org/obo/IAO_0000125) [label](http://www.w3.org/2000/01/rdf-schema#label) "pending final vetting"@en +- [pyrophosphatase activity](http://purl.obolibrary.org/obo/GO_0016462) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "molecular_function" -- Individual: [pending final vetting](http://purl.obolibrary.org/obo/IAO_0000125) +- [pyrophosphatase activity](http://purl.obolibrary.org/obo/GO_0016462) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-6810472" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "NUDT13 hydrolyses AP6A to AP4 and ADP" +- Class: [pyrophosphatase activity](http://purl.obolibrary.org/obo/GO_0016462) -### perforin-1 `http://purl.obolibrary.org/obo/PR_000003466` +- [pyrophosphatase activity](http://purl.obolibrary.org/obo/GO_0016462) SubClassOf [hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides](http://purl.obolibrary.org/obo/GO_0016818) -#### Added -- [perforin-1](http://purl.obolibrary.org/obo/PR_000003466) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [perforin-1 (human)](http://purl.obolibrary.org/obo/PR_P14222) -### pericardium `http://purl.obolibrary.org/obo/UBERON_0002407` +### ready for release `http://purl.obolibrary.org/obo/IAO_0000122` #### Removed -- [pericardium](http://purl.obolibrary.org/obo/UBERON_0002407) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [ready for release](http://purl.obolibrary.org/obo/IAO_0000122) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Class has undergone final review, is ready for use, and will be included in the next release. Any class lacking "ready_for_release" should be considered likely to change place in hierarchy, have its definition refined, or be obsoleted in the next release. Those classes deemed "ready_for_release" will also derived from a chain of ancestor classes that are also "ready_for_release.""@en +- [ready for release](http://purl.obolibrary.org/obo/IAO_0000122) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "ready for release"@en +- [ready for release](http://purl.obolibrary.org/obo/IAO_0000122) [label](http://www.w3.org/2000/01/rdf-schema#label) "ready for release"@en -### periderm `http://purl.obolibrary.org/obo/UBERON_0003055` -#### Removed -- [periderm](http://purl.obolibrary.org/obo/UBERON_0003055) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- Individual: [ready for release](http://purl.obolibrary.org/obo/IAO_0000122) -### periodontium `http://purl.obolibrary.org/obo/UBERON_0001758` +### regulation of ATP-dependent activity `http://purl.obolibrary.org/obo/GO_0043462` #### Removed -- [periodontium](http://purl.obolibrary.org/obo/UBERON_0001758) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) - +- [regulation of ATP-dependent activity](http://purl.obolibrary.org/obo/GO_0043462) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0043462" +- [regulation of ATP-dependent activity](http://purl.obolibrary.org/obo/GO_0043462) [term tracker item](http://purl.obolibrary.org/obo/IAO_0000233) "https://github.com/geneontology/go-ontology/issues/22371"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI) -### peripheral blood mesothelial cell `http://purl.obolibrary.org/obo/CL_0002318` -#### Removed -- [peripheral blood mesothelial cell](http://purl.obolibrary.org/obo/CL_0002318) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [regulation of ATP-dependent activity](http://purl.obolibrary.org/obo/GO_0043462) [label](http://www.w3.org/2000/01/rdf-schema#label) "regulation of ATP-dependent activity" +- [regulation of ATP-dependent activity](http://purl.obolibrary.org/obo/GO_0043462) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate) +- [regulation of ATP-dependent activity](http://purl.obolibrary.org/obo/GO_0043462) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" -### peritoneal cavity `http://purl.obolibrary.org/obo/UBERON_0001179` -#### Removed -- [peritoneal cavity](http://purl.obolibrary.org/obo/UBERON_0001179) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [regulation of ATP-dependent activity](http://purl.obolibrary.org/obo/GO_0043462) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that modulates the rate of an ATP-dependent activity." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:jl" +- [regulation of ATP-dependent activity](http://purl.obolibrary.org/obo/GO_0043462) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "regulation of ATPase activity" +- [regulation of ATP-dependent activity](http://purl.obolibrary.org/obo/GO_0043462) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "regulation of adenosinetriphosphatase activity" -### peritoneal macrophage `http://purl.obolibrary.org/obo/CL_0000581` -#### Removed -- [peritoneal macrophage](http://purl.obolibrary.org/obo/CL_0000581) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- Class: [regulation of ATP-dependent activity](http://purl.obolibrary.org/obo/GO_0043462) +- [regulation of ATP-dependent activity](http://purl.obolibrary.org/obo/GO_0043462) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([regulates](http://purl.obolibrary.org/obo/RO_0002211) some [ATP-dependent activity](http://purl.obolibrary.org/obo/GO_0140657)) +- [regulation of ATP-dependent activity](http://purl.obolibrary.org/obo/GO_0043462) SubClassOf [regulates](http://purl.obolibrary.org/obo/RO_0002211) some [ATP-dependent activity](http://purl.obolibrary.org/obo/GO_0140657) -### perivascular macrophage `http://purl.obolibrary.org/obo/CL_0000881` -#### Removed -- [perivascular macrophage](http://purl.obolibrary.org/obo/CL_0000881) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [regulation of ATP-dependent activity](http://purl.obolibrary.org/obo/GO_0043462) SubClassOf [regulation of molecular function](http://purl.obolibrary.org/obo/GO_0065009) -### pharyngeal arch `http://purl.obolibrary.org/obo/UBERON_0002539` +### regulation of Atg1/ULK1 kinase complex assembly `http://purl.obolibrary.org/obo/GO_1905864` #### Removed -- [pharyngeal arch](http://purl.obolibrary.org/obo/UBERON_0002539) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) - +- [regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905864) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "regulation of ULK1-ATG13-RB1CC1 complex formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" +- [regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905864) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2017-01-26T13:23:26Z" -### pharyngeal membrane `http://purl.obolibrary.org/obo/UBERON_0009210` -#### Removed -- [pharyngeal membrane](http://purl.obolibrary.org/obo/UBERON_0009210) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905864) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "regulation of ATG1-ATG13 complex formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" +- [regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905864) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "regulation of Atg1p signalling complex assembly" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" +- [regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905864) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" -### phrenic nerve `http://purl.obolibrary.org/obo/UBERON_0001884` -#### Removed -- [phrenic nerve](http://purl.obolibrary.org/obo/UBERON_0001884) SubClassOf [neuron projection bundle](http://purl.obolibrary.org/obo/CARO_0001001) +- [regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905864) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "regulation of ATG1-ATG13 complex assembly" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" +- [regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905864) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that modulates the frequency, rate or extent of Atg1/ULK1 kinase complex assembly." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:mf" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:autophagy" -### pilosebaceous unit `http://purl.obolibrary.org/obo/UBERON_0011932` -#### Removed -- [pilosebaceous unit](http://purl.obolibrary.org/obo/UBERON_0011932) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:26567215" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GO_REF:0000058" -### pineal tract `http://purl.obolibrary.org/obo/UBERON_0034715` -#### Removed -- [pineal tract](http://purl.obolibrary.org/obo/UBERON_0034715) SubClassOf [neuron projection bundle](http://purl.obolibrary.org/obo/CARO_0001001) +- [regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905864) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "regulation of ATG1/ULK1 signaling complex formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" +- [regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905864) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "regulation of ATG1/ULK1 signaling complex assembly" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" +- [regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905864) [label](http://www.w3.org/2000/01/rdf-schema#label) "regulation of Atg1/ULK1 kinase complex assembly" -### pinna `http://purl.obolibrary.org/obo/UBERON_0001757` -#### Removed -- [pinna](http://purl.obolibrary.org/obo/UBERON_0001757) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905864) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "regulation of Atg1p signalling complex formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" +- [regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905864) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "regulation of ULK1-ATG13-FIP200 complex formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" +- [regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905864) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "regulation of ULK1 signaling complex assembly" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" -### placeholder removed `http://purl.obolibrary.org/obo/IAO_0000226` +- [regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905864) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "regulation of ULK1 signaling complex formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" -#### Added -- [placeholder removed](http://purl.obolibrary.org/obo/IAO_0000226) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "placeholder removed"@en +- [regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905864) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "pr" -- [placeholder removed](http://purl.obolibrary.org/obo/IAO_0000226) [label](http://www.w3.org/2000/01/rdf-schema#label) "placeholder removed"@en +- [regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905864) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "regulation of ULK1-ATG13-RB1CC1 complex assembly" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" -- Individual: [placeholder removed](http://purl.obolibrary.org/obo/IAO_0000226) +- [regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905864) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "regulation of ATG1/ULK1 kinase complex formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" +- [regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905864) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "regulation of ATG1 kinase complex assembly" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" -### plantar nerve `http://purl.obolibrary.org/obo/UBERON_0035109` -#### Removed -- [plantar nerve](http://purl.obolibrary.org/obo/UBERON_0035109) SubClassOf [neuron projection bundle](http://purl.obolibrary.org/obo/CARO_0001001) +- [regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905864) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:1905864" +- [regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905864) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "regulation of ULK1-ATG13-FIP200 complex assembly" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" +- [regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905864) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "regulation of ATG1 kinase complex formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" -### plasma cell `http://purl.obolibrary.org/obo/CL_0000786` -#### Removed -- [plasma cell](http://purl.obolibrary.org/obo/CL_0000786) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- Class: [regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905864) +- [regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905864) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([regulates](http://purl.obolibrary.org/obo/RO_0002211) some [Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1904745)) +- [regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905864) SubClassOf [regulation of protein-containing complex assembly](http://purl.obolibrary.org/obo/GO_0043254) -### platelet glycoprotein 4 `http://purl.obolibrary.org/obo/PR_000001905` +- [regulation of Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1905864) SubClassOf [regulates](http://purl.obolibrary.org/obo/RO_0002211) some [Atg1/ULK1 kinase complex assembly](http://purl.obolibrary.org/obo/GO_1904745) -#### Added -- [platelet glycoprotein 4](http://purl.obolibrary.org/obo/PR_000001905) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [platelet glycoprotein 4 (human)](http://purl.obolibrary.org/obo/PR_P16671) -### platelet glycoprotein Ib alpha chain `http://purl.obolibrary.org/obo/PR_000001907` +### regulation of Golgi calcium ion export `http://purl.obolibrary.org/obo/GO_1901472` #### Added -- [platelet glycoprotein Ib alpha chain](http://purl.obolibrary.org/obo/PR_000001907) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [platelet glycoprotein Ib alpha chain (human)](http://purl.obolibrary.org/obo/PR_P07359) +- [regulation of Golgi calcium ion export](http://purl.obolibrary.org/obo/GO_1901472) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" +- [regulation of Golgi calcium ion export](http://purl.obolibrary.org/obo/GO_1901472) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:1901472" -### pleura `http://purl.obolibrary.org/obo/UBERON_0000977` -#### Removed -- [pleura](http://purl.obolibrary.org/obo/UBERON_0000977) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [regulation of Golgi calcium ion export](http://purl.obolibrary.org/obo/GO_1901472) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2012-10-03T07:26:03Z" +- [regulation of Golgi calcium ion export](http://purl.obolibrary.org/obo/GO_1901472) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that modulates the frequency, rate or extent of Golgi calcium ion export." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" +- [regulation of Golgi calcium ion export](http://purl.obolibrary.org/obo/GO_1901472) [label](http://www.w3.org/2000/01/rdf-schema#label) "regulation of Golgi calcium ion export" -### pleural cavity `http://purl.obolibrary.org/obo/UBERON_0002402` -#### Removed -- [pleural cavity](http://purl.obolibrary.org/obo/UBERON_0002402) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [regulation of Golgi calcium ion export](http://purl.obolibrary.org/obo/GO_1901472) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "al" +- Class: [regulation of Golgi calcium ion export](http://purl.obolibrary.org/obo/GO_1901472) +- [regulation of Golgi calcium ion export](http://purl.obolibrary.org/obo/GO_1901472) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([regulates](http://purl.obolibrary.org/obo/RO_0002211) some [release of sequestered calcium ion into cytosol by Golgi](http://purl.obolibrary.org/obo/GO_0061454)) -### pleuroperitoneal canal lumen `http://purl.obolibrary.org/obo/UBERON_0014704` -#### Removed -- [pleuroperitoneal canal lumen](http://purl.obolibrary.org/obo/UBERON_0014704) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [regulation of Golgi calcium ion export](http://purl.obolibrary.org/obo/GO_1901472) SubClassOf [regulation of release of sequestered calcium ion into cytosol](http://purl.obolibrary.org/obo/GO_0051279) +- [regulation of Golgi calcium ion export](http://purl.obolibrary.org/obo/GO_1901472) SubClassOf [regulates](http://purl.obolibrary.org/obo/RO_0002211) some [release of sequestered calcium ion into cytosol by Golgi](http://purl.obolibrary.org/obo/GO_0061454) -### polychromatophilic erythroblast `http://purl.obolibrary.org/obo/CL_0000550` -#### Removed -- [polychromatophilic erythroblast](http://purl.obolibrary.org/obo/CL_0000550) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +### regulation of L-glutamate import across plasma membrane `http://purl.obolibrary.org/obo/GO_0002036` +#### Added +- [regulation of L-glutamate import across plasma membrane](http://purl.obolibrary.org/obo/GO_0002036) [has_alternative_id](http://www.geneontology.org/formats/oboInOwl#hasAlternativeId) "GO:1900920" +- [regulation of L-glutamate import across plasma membrane](http://purl.obolibrary.org/obo/GO_0002036) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "regulation of L-glutamate import" -### pontine tegmentum `http://purl.obolibrary.org/obo/UBERON_0003023` -#### Removed -- [pontine tegmentum](http://purl.obolibrary.org/obo/UBERON_0003023) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [regulation of L-glutamate import across plasma membrane](http://purl.obolibrary.org/obo/GO_0002036) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" +- [regulation of L-glutamate import across plasma membrane](http://purl.obolibrary.org/obo/GO_0002036) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "al" +- [regulation of L-glutamate import across plasma membrane](http://purl.obolibrary.org/obo/GO_0002036) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that modulates the frequency, rate or extent of L-glutamate import into a cell." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" -### portal triad `http://purl.obolibrary.org/obo/UBERON_0001279` -#### Removed -- [portal triad](http://purl.obolibrary.org/obo/UBERON_0001279) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [regulation of L-glutamate import across plasma membrane](http://purl.obolibrary.org/obo/GO_0002036) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "regulation of L-glutamate uptake" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" +- [regulation of L-glutamate import across plasma membrane](http://purl.obolibrary.org/obo/GO_0002036) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "regulation of L-glutamate transport" +- [regulation of L-glutamate import across plasma membrane](http://purl.obolibrary.org/obo/GO_0002036) [label](http://www.w3.org/2000/01/rdf-schema#label) "regulation of L-glutamate import across plasma membrane" -### positively correlated with `http://purl.obolibrary.org/obo/RO_0017003` +- [regulation of L-glutamate import across plasma membrane](http://purl.obolibrary.org/obo/GO_0002036) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0002036" -#### Added -- [positively correlated with](http://purl.obolibrary.org/obo/RO_0017003) [contributor](http://purl.org/dc/terms/contributor) [0000-0003-1909-9269](https://orcid.org/0000-0003-1909-9269) +- [regulation of L-glutamate import across plasma membrane](http://purl.obolibrary.org/obo/GO_0002036) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2012-06-13T07:34:08Z" -- [positively correlated with](http://purl.obolibrary.org/obo/RO_0017003) [IAO_0000118](http://purl.obolibrary.org/obo/IAO_0000118) "directly correlated with"@en +- Class: [regulation of L-glutamate import across plasma membrane](http://purl.obolibrary.org/obo/GO_0002036) -- [positively correlated with](http://purl.obolibrary.org/obo/RO_0017003) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A relation between entities in which one increases or decreases as the other does the same."@en +- [regulation of L-glutamate import across plasma membrane](http://purl.obolibrary.org/obo/GO_0002036) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([regulates](http://purl.obolibrary.org/obo/RO_0002211) some [L-glutamate import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098712)) -- [positively correlated with](http://purl.obolibrary.org/obo/RO_0017003) [label](http://www.w3.org/2000/01/rdf-schema#label) "positively correlated with"@en +- [regulation of L-glutamate import across plasma membrane](http://purl.obolibrary.org/obo/GO_0002036) SubClassOf [regulates](http://purl.obolibrary.org/obo/RO_0002211) some [L-glutamate import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098712) -- ObjectProperty: [positively correlated with](http://purl.obolibrary.org/obo/RO_0017003) +- [regulation of L-glutamate import across plasma membrane](http://purl.obolibrary.org/obo/GO_0002036) SubClassOf [regulation of amino acid import across plasma membrane](http://purl.obolibrary.org/obo/GO_0010958) -- Reflexive: [positively correlated with](http://purl.obolibrary.org/obo/RO_0017003) -- [positively correlated with](http://purl.obolibrary.org/obo/RO_0017003) SubPropertyOf: [correlated with](http://purl.obolibrary.org/obo/RO_0002610) +### regulation of RNA biosynthetic process `http://purl.obolibrary.org/obo/GO_2001141` +#### Removed +- [regulation of RNA biosynthetic process](http://purl.obolibrary.org/obo/GO_2001141) SubClassOf [regulation of biosynthetic process](http://purl.obolibrary.org/obo/GO_0009889) -- Symmetric: [positively correlated with](http://purl.obolibrary.org/obo/RO_0017003) +#### Added +- [regulation of RNA biosynthetic process](http://purl.obolibrary.org/obo/GO_2001141) SubClassOf [regulation of macromolecule biosynthetic process](http://purl.obolibrary.org/obo/GO_0010556) -### post-anal tail `http://purl.obolibrary.org/obo/UBERON_0007812` -#### Removed -- [post-anal tail](http://purl.obolibrary.org/obo/UBERON_0007812) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +### regulation of RNA export from nucleus `http://purl.obolibrary.org/obo/GO_0046831` +#### Added +- [regulation of RNA export from nucleus](http://purl.obolibrary.org/obo/GO_0046831) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "regulation of RNA export from cell nucleus" +- [regulation of RNA export from nucleus](http://purl.obolibrary.org/obo/GO_0046831) [label](http://www.w3.org/2000/01/rdf-schema#label) "regulation of RNA export from nucleus" -### postcranial axial skeletal system `http://purl.obolibrary.org/obo/UBERON_0011138` -#### Removed -- [postcranial axial skeletal system](http://purl.obolibrary.org/obo/UBERON_0011138) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [regulation of RNA export from nucleus](http://purl.obolibrary.org/obo/GO_0046831) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "regulation of RNA transport from nucleus to cytoplasm" +- [regulation of RNA export from nucleus](http://purl.obolibrary.org/obo/GO_0046831) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "regulation of RNA export out of nucleus" +- [regulation of RNA export from nucleus](http://purl.obolibrary.org/obo/GO_0046831) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that modulates the frequency, rate or extent of the directed movement of RNA from the nucleus to the cytoplasm." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:bf" -### postcranial axial skeleton `http://purl.obolibrary.org/obo/UBERON_0002090` -#### Removed -- [postcranial axial skeleton](http://purl.obolibrary.org/obo/UBERON_0002090) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [regulation of RNA export from nucleus](http://purl.obolibrary.org/obo/GO_0046831) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0046831" +- [regulation of RNA export from nucleus](http://purl.obolibrary.org/obo/GO_0046831) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" +- [regulation of RNA export from nucleus](http://purl.obolibrary.org/obo/GO_0046831) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "regulation of RNA-nucleus export" -### posterior neural tube `http://purl.obolibrary.org/obo/UBERON_0003076` -#### Removed -- [posterior neural tube](http://purl.obolibrary.org/obo/UBERON_0003076) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- Class: [regulation of RNA export from nucleus](http://purl.obolibrary.org/obo/GO_0046831) +- [regulation of RNA export from nucleus](http://purl.obolibrary.org/obo/GO_0046831) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([regulates](http://purl.obolibrary.org/obo/RO_0002211) some [RNA export from nucleus](http://purl.obolibrary.org/obo/GO_0006405)) +- [regulation of RNA export from nucleus](http://purl.obolibrary.org/obo/GO_0046831) SubClassOf [regulates](http://purl.obolibrary.org/obo/RO_0002211) some [RNA export from nucleus](http://purl.obolibrary.org/obo/GO_0006405) -### pre-conventional dendritic cell `http://purl.obolibrary.org/obo/CL_0002010` -#### Removed -- [pre-conventional dendritic cell](http://purl.obolibrary.org/obo/CL_0002010) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [regulation of RNA export from nucleus](http://purl.obolibrary.org/obo/GO_0046831) SubClassOf [regulation of nucleocytoplasmic transport](http://purl.obolibrary.org/obo/GO_0046822) +### regulation of RNA import into nucleus `http://purl.obolibrary.org/obo/GO_0046828` -### pre-natural killer cell `http://purl.obolibrary.org/obo/CL_0000937` -#### Removed -- [pre-natural killer cell](http://purl.obolibrary.org/obo/CL_0000937) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +#### Added +- [regulation of RNA import into nucleus](http://purl.obolibrary.org/obo/GO_0046828) [label](http://www.w3.org/2000/01/rdf-schema#label) "regulation of RNA import into nucleus" +- [regulation of RNA import into nucleus](http://purl.obolibrary.org/obo/GO_0046828) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that modulates the frequency, rate or extent of movement of RNA from the cytoplasm to the nucleus." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:bf" +- [regulation of RNA import into nucleus](http://purl.obolibrary.org/obo/GO_0046828) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "regulation of RNA import into cell nucleus" -### preameloblast `http://purl.obolibrary.org/obo/CL_0007000` -#### Removed -- [preameloblast](http://purl.obolibrary.org/obo/CL_0007000) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [regulation of RNA import into nucleus](http://purl.obolibrary.org/obo/GO_0046828) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" +- [regulation of RNA import into nucleus](http://purl.obolibrary.org/obo/GO_0046828) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "regulation of RNA-nucleus import" +- [regulation of RNA import into nucleus](http://purl.obolibrary.org/obo/GO_0046828) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "regulation of RNA transport from cytoplasm to nucleus" -### prechordal mesoderm `http://purl.obolibrary.org/obo/UBERON_0034878` -#### Removed -- [prechordal mesoderm](http://purl.obolibrary.org/obo/UBERON_0034878) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [regulation of RNA import into nucleus](http://purl.obolibrary.org/obo/GO_0046828) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0046828" +- Class: [regulation of RNA import into nucleus](http://purl.obolibrary.org/obo/GO_0046828) +- [regulation of RNA import into nucleus](http://purl.obolibrary.org/obo/GO_0046828) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([regulates](http://purl.obolibrary.org/obo/RO_0002211) some [RNA import into nucleus](http://purl.obolibrary.org/obo/GO_0006404)) -### prechordal plate `http://purl.obolibrary.org/obo/UBERON_0003063` -#### Removed -- [prechordal plate](http://purl.obolibrary.org/obo/UBERON_0003063) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [regulation of RNA import into nucleus](http://purl.obolibrary.org/obo/GO_0046828) SubClassOf [regulation of nucleocytoplasmic transport](http://purl.obolibrary.org/obo/GO_0046822) +- [regulation of RNA import into nucleus](http://purl.obolibrary.org/obo/GO_0046828) SubClassOf [regulates](http://purl.obolibrary.org/obo/RO_0002211) some [RNA import into nucleus](http://purl.obolibrary.org/obo/GO_0006404) -### preferred_root `http://purl.obolibrary.org/obo/IAO_0000700` +### regulation of amino acid import across plasma membrane `http://purl.obolibrary.org/obo/GO_0010958` #### Added -- [preferred_root](http://purl.obolibrary.org/obo/IAO_0000700) [label](http://www.w3.org/2000/01/rdf-schema#label) "has ontology root term"@en +- [regulation of amino acid import across plasma membrane](http://purl.obolibrary.org/obo/GO_0010958) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "regulation of amino acid import" -- [preferred_root](http://purl.obolibrary.org/obo/IAO_0000700) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "has ontology root term"@en +- [regulation of amino acid import across plasma membrane](http://purl.obolibrary.org/obo/GO_0010958) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0010958" -- [preferred_root](http://purl.obolibrary.org/obo/IAO_0000700) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Ontology annotation property. Relates an ontology to a term that is a designated root term of the ontology. Display tools like OLS can use terms annotated with this property as the starting point for rendering the ontology class hierarchy. There can be more than one root."@en +- [regulation of amino acid import across plasma membrane](http://purl.obolibrary.org/obo/GO_0010958) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that modulates the frequency, rate or extent of amino acid import into a cell." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dph" -- [preferred_root](http://purl.obolibrary.org/obo/IAO_0000700) [IAO_0000117](http://purl.obolibrary.org/obo/IAO_0000117) "Nicolas Matentzoglu"@en + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:tb" +- [regulation of amino acid import across plasma membrane](http://purl.obolibrary.org/obo/GO_0010958) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "tb" -### premigratory neural crest cell `http://purl.obolibrary.org/obo/CL_0007004` -#### Removed -- [premigratory neural crest cell](http://purl.obolibrary.org/obo/CL_0007004) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [regulation of amino acid import across plasma membrane](http://purl.obolibrary.org/obo/GO_0010958) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2009-05-06T11:33:12Z" +- [regulation of amino acid import across plasma membrane](http://purl.obolibrary.org/obo/GO_0010958) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" +- [regulation of amino acid import across plasma membrane](http://purl.obolibrary.org/obo/GO_0010958) [label](http://www.w3.org/2000/01/rdf-schema#label) "regulation of amino acid import across plasma membrane" -### presumptive rhombomere 1 `http://purl.obolibrary.org/obo/UBERON_0007289` +- Class: [regulation of amino acid import across plasma membrane](http://purl.obolibrary.org/obo/GO_0010958) + +- [regulation of amino acid import across plasma membrane](http://purl.obolibrary.org/obo/GO_0010958) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([regulates](http://purl.obolibrary.org/obo/RO_0002211) some [amino acid import across plasma membrane](http://purl.obolibrary.org/obo/GO_0089718)) + +- [regulation of amino acid import across plasma membrane](http://purl.obolibrary.org/obo/GO_0010958) SubClassOf [regulation of amino acid transmembrane transport](http://purl.obolibrary.org/obo/GO_1903789) + +- [regulation of amino acid import across plasma membrane](http://purl.obolibrary.org/obo/GO_0010958) SubClassOf [regulates](http://purl.obolibrary.org/obo/RO_0002211) some [amino acid import across plasma membrane](http://purl.obolibrary.org/obo/GO_0089718) + + +### regulation of anterograde dense core granule transport `http://purl.obolibrary.org/obo/GO_1901951` #### Added -- [presumptive rhombomere 1](http://purl.obolibrary.org/obo/UBERON_0007289) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ZFA:0001207" +- [regulation of anterograde dense core granule transport](http://purl.obolibrary.org/obo/GO_1901951) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:1901951" -- [presumptive rhombomere 1](http://purl.obolibrary.org/obo/UBERON_0007289) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "TAO:0001207" +- [regulation of anterograde dense core granule transport](http://purl.obolibrary.org/obo/GO_1901951) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2013-02-19T13:36:21Z" -- [presumptive rhombomere 1](http://purl.obolibrary.org/obo/UBERON_0007289) [label](http://www.w3.org/2000/01/rdf-schema#label) "presumptive rhombomere 1" +- [regulation of anterograde dense core granule transport](http://purl.obolibrary.org/obo/GO_1901951) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "pr" -- [presumptive rhombomere 1](http://purl.obolibrary.org/obo/UBERON_0007289) [id](http://www.geneontology.org/formats/oboInOwl#id) "UBERON:0007289" +- [regulation of anterograde dense core granule transport](http://purl.obolibrary.org/obo/GO_1901951) [label](http://www.w3.org/2000/01/rdf-schema#label) "regulation of anterograde dense core granule transport" -- [presumptive rhombomere 1](http://purl.obolibrary.org/obo/UBERON_0007289) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "uberon" +- [regulation of anterograde dense core granule transport](http://purl.obolibrary.org/obo/GO_1901951) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that modulates the frequency, rate or extent of anterograde dense core granule transport." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:23358451" -- [presumptive rhombomere 1](http://purl.obolibrary.org/obo/UBERON_0007289) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A presumptive structure that has the potential to develop into a rhombomere 1." - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "OBOL:automatic" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" -- Class: [presumptive rhombomere 1](http://purl.obolibrary.org/obo/UBERON_0007289) + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:kmv" -- [presumptive rhombomere 1](http://purl.obolibrary.org/obo/UBERON_0007289) EquivalentTo [presumptive structure](http://purl.obolibrary.org/obo/UBERON_0006598) and ([has potential to develop into](http://purl.obolibrary.org/obo/RO_0002387) some [rhombomere 1](http://purl.obolibrary.org/obo/UBERON_0005499)) +- [regulation of anterograde dense core granule transport](http://purl.obolibrary.org/obo/GO_1901951) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" -- [presumptive rhombomere 1](http://purl.obolibrary.org/obo/UBERON_0007289) SubClassOf [has potential to develop into](http://purl.obolibrary.org/obo/RO_0002387) some [rhombomere 1](http://purl.obolibrary.org/obo/UBERON_0005499) +- Class: [regulation of anterograde dense core granule transport](http://purl.obolibrary.org/obo/GO_1901951) -- [presumptive rhombomere 1](http://purl.obolibrary.org/obo/UBERON_0007289) SubClassOf [presumptive structure](http://purl.obolibrary.org/obo/UBERON_0006598) +- [regulation of anterograde dense core granule transport](http://purl.obolibrary.org/obo/GO_1901951) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([regulates](http://purl.obolibrary.org/obo/RO_0002211) some [anterograde neuronal dense core vesicle transport](http://purl.obolibrary.org/obo/GO_1990048)) +- [regulation of anterograde dense core granule transport](http://purl.obolibrary.org/obo/GO_1901951) SubClassOf [regulation of vesicle transport along microtubule](http://purl.obolibrary.org/obo/GO_1901608) -### presumptive structure `http://purl.obolibrary.org/obo/UBERON_0006598` -#### Removed -- [presumptive structure](http://purl.obolibrary.org/obo/UBERON_0006598) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [regulation of anterograde dense core granule transport](http://purl.obolibrary.org/obo/GO_1901951) SubClassOf [regulates](http://purl.obolibrary.org/obo/RO_0002211) some [anterograde neuronal dense core vesicle transport](http://purl.obolibrary.org/obo/GO_1990048) +- [regulation of anterograde dense core granule transport](http://purl.obolibrary.org/obo/GO_1901951) SubClassOf [regulation of dense core granule transport](http://purl.obolibrary.org/obo/GO_1904809) -### primary interneuron `http://purl.obolibrary.org/obo/CL_0000534` +### regulation of autophagic cell death `http://purl.obolibrary.org/obo/GO_1904092` #### Removed -- [primary interneuron](http://purl.obolibrary.org/obo/CL_0000534) [label](http://www.w3.org/2000/01/rdf-schema#label) "primary interneuron" +- [regulation of autophagic cell death](http://purl.obolibrary.org/obo/GO_1904092) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "regulation of programmed cell death by macroautophagy" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" -#### Added -- [primary interneuron](http://purl.obolibrary.org/obo/CL_0000534) [label](http://www.w3.org/2000/01/rdf-schema#label) "primary interneuron (sensu Teleostei)" +- [regulation of autophagic cell death](http://purl.obolibrary.org/obo/GO_1904092) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" -- [primary interneuron](http://purl.obolibrary.org/obo/CL_0000534) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A primary neuron (sensu Teleostei) that is neither a sensory neuron or a motor neuron." - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:1842357" +- [regulation of autophagic cell death](http://purl.obolibrary.org/obo/GO_1904092) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that modulates the frequency, rate or extent of autophagic cell death." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:bhm" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" -### primary lens fiber `http://purl.obolibrary.org/obo/CL_0002228` -#### Removed -- [primary lens fiber](http://purl.obolibrary.org/obo/CL_0002228) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:25736836" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GO_REF:0000058" +- [regulation of autophagic cell death](http://purl.obolibrary.org/obo/GO_1904092) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "bhm" -### primary motor neuron `http://purl.obolibrary.org/obo/CL_0000533` -#### Removed -- [primary motor neuron](http://purl.obolibrary.org/obo/CL_0000533) [label](http://www.w3.org/2000/01/rdf-schema#label) "primary motor neuron" +- [regulation of autophagic cell death](http://purl.obolibrary.org/obo/GO_1904092) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2015-03-26T16:41:32Z" -- [primary motor neuron](http://purl.obolibrary.org/obo/CL_0000533) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "FMA:83619" +- [regulation of autophagic cell death](http://purl.obolibrary.org/obo/GO_1904092) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:1904092" -#### Added -- [primary motor neuron](http://purl.obolibrary.org/obo/CL_0000533) [label](http://www.w3.org/2000/01/rdf-schema#label) "primary motor neuron (sensu Teleostei)" +- [regulation of autophagic cell death](http://purl.obolibrary.org/obo/GO_1904092) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "regulation of type II programmed cell death" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" -- [primary motor neuron](http://purl.obolibrary.org/obo/CL_0000533) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A primary neuron (sensu Teleostei) that has a motor function." - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:1842357" +- [regulation of autophagic cell death](http://purl.obolibrary.org/obo/GO_1904092) [label](http://www.w3.org/2000/01/rdf-schema#label) "regulation of autophagic cell death" + +- [regulation of autophagic cell death](http://purl.obolibrary.org/obo/GO_1904092) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "regulation of autophagic death" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" +- [regulation of autophagic cell death](http://purl.obolibrary.org/obo/GO_1904092) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "regulation of programmed cell death by autophagy" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" -### primary neuron `http://purl.obolibrary.org/obo/CL_0000530` -#### Removed -- [primary neuron](http://purl.obolibrary.org/obo/CL_0000530) [label](http://www.w3.org/2000/01/rdf-schema#label) "primary neuron" +- Class: [regulation of autophagic cell death](http://purl.obolibrary.org/obo/GO_1904092) -#### Added -- [primary neuron](http://purl.obolibrary.org/obo/CL_0000530) [label](http://www.w3.org/2000/01/rdf-schema#label) "primary neuron (sensu Teleostei)" +- [regulation of autophagic cell death](http://purl.obolibrary.org/obo/GO_1904092) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([regulates](http://purl.obolibrary.org/obo/RO_0002211) some [autophagic cell death](http://purl.obolibrary.org/obo/GO_0048102)) -- [primary neuron](http://purl.obolibrary.org/obo/CL_0000530) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A neuron that develops during the early segmentation stages in teleosts, before the neural tube is formed." - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:1842357" +- [regulation of autophagic cell death](http://purl.obolibrary.org/obo/GO_1904092) SubClassOf [regulation of programmed cell death](http://purl.obolibrary.org/obo/GO_0043067) - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1242/dev.108.1.121" +- [regulation of autophagic cell death](http://purl.obolibrary.org/obo/GO_1904092) SubClassOf [regulates](http://purl.obolibrary.org/obo/RO_0002211) some [autophagic cell death](http://purl.obolibrary.org/obo/GO_0048102) -- [primary neuron](http://purl.obolibrary.org/obo/CL_0000530) SubClassOf [only in taxon](http://purl.obolibrary.org/obo/RO_0002160) some [Teleostei](http://purl.obolibrary.org/obo/NCBITaxon_32443) - - [term tracker item](http://purl.obolibrary.org/obo/IAO_0000233) "https://github.com/obophenotype/cell-ontology/pull/1950" -### primary nodular lymphoid tissue `http://purl.obolibrary.org/obo/UBERON_0010422` +### regulation of autophagosome assembly `http://purl.obolibrary.org/obo/GO_2000785` #### Removed -- [primary nodular lymphoid tissue](http://purl.obolibrary.org/obo/UBERON_0010422) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [regulation of autophagosome assembly](http://purl.obolibrary.org/obo/GO_2000785) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "regulation of autophagosome biosynthesis" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:obol" +- [regulation of autophagosome assembly](http://purl.obolibrary.org/obo/GO_2000785) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "regulation of autophagosome formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:obol" +- [regulation of autophagosome assembly](http://purl.obolibrary.org/obo/GO_2000785) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:2000785" -### primary oocyte `http://purl.obolibrary.org/obo/CL_0000654` -#### Removed -- [primary oocyte](http://purl.obolibrary.org/obo/CL_0000654) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [regulation of autophagosome assembly](http://purl.obolibrary.org/obo/GO_2000785) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "regulation of autophagic vacuole formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:obol" +- [regulation of autophagosome assembly](http://purl.obolibrary.org/obo/GO_2000785) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "rl" +- [regulation of autophagosome assembly](http://purl.obolibrary.org/obo/GO_2000785) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that modulates the frequency, rate or extent of autophagosome assembly." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:autophagy" -### primary sensory neuron `http://purl.obolibrary.org/obo/CL_0000531` -#### Removed -- [primary sensory neuron](http://purl.obolibrary.org/obo/CL_0000531) [label](http://www.w3.org/2000/01/rdf-schema#label) "primary sensory neuron" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:BHF" -#### Added -- [primary sensory neuron](http://purl.obolibrary.org/obo/CL_0000531) [label](http://www.w3.org/2000/01/rdf-schema#label) "primary sensory neuron (sensu Teleostei)" +- [regulation of autophagosome assembly](http://purl.obolibrary.org/obo/GO_2000785) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2011-06-24T11:19:08Z" -- [primary sensory neuron](http://purl.obolibrary.org/obo/CL_0000531) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A primary neuron (sensu Teleostei) that has a sensory function." - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:1842357" +- [regulation of autophagosome assembly](http://purl.obolibrary.org/obo/GO_2000785) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "regulation of autophagic vacuole assembly" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:autophagy" +- [regulation of autophagosome assembly](http://purl.obolibrary.org/obo/GO_2000785) [label](http://www.w3.org/2000/01/rdf-schema#label) "regulation of autophagosome assembly" -### primitive erythroid progenitor `http://purl.obolibrary.org/obo/CL_0002361` -#### Removed -- [primitive erythroid progenitor](http://purl.obolibrary.org/obo/CL_0002361) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [regulation of autophagosome assembly](http://purl.obolibrary.org/obo/GO_2000785) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" +- [regulation of autophagosome assembly](http://purl.obolibrary.org/obo/GO_2000785) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "regulation of PAS formation" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:obol" +- Class: [regulation of autophagosome assembly](http://purl.obolibrary.org/obo/GO_2000785) -### primitive nephron `http://purl.obolibrary.org/obo/UBERON_0010532` -#### Removed -- [primitive nephron](http://purl.obolibrary.org/obo/UBERON_0010532) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [regulation of autophagosome assembly](http://purl.obolibrary.org/obo/GO_2000785) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([regulates](http://purl.obolibrary.org/obo/RO_0002211) some [autophagosome assembly](http://purl.obolibrary.org/obo/GO_0000045)) +- [regulation of autophagosome assembly](http://purl.obolibrary.org/obo/GO_2000785) SubClassOf [regulation of vacuole organization](http://purl.obolibrary.org/obo/GO_0044088) +- [regulation of autophagosome assembly](http://purl.obolibrary.org/obo/GO_2000785) SubClassOf [regulates](http://purl.obolibrary.org/obo/RO_0002211) some [autophagosome assembly](http://purl.obolibrary.org/obo/GO_0000045) -### primitive streak `http://purl.obolibrary.org/obo/UBERON_0004341` -#### Removed -- [primitive streak](http://purl.obolibrary.org/obo/UBERON_0004341) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [regulation of autophagosome assembly](http://purl.obolibrary.org/obo/GO_2000785) SubClassOf [regulation of organelle assembly](http://purl.obolibrary.org/obo/GO_1902115) -### primitive urogenital sinus `http://purl.obolibrary.org/obo/UBERON_0000164` +### regulation of autophagy `http://purl.obolibrary.org/obo/GO_0010506` #### Removed -- [primitive urogenital sinus](http://purl.obolibrary.org/obo/UBERON_0000164) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [regulation of autophagy](http://purl.obolibrary.org/obo/GO_0010506) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dph" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:tb" +- [regulation of autophagy](http://purl.obolibrary.org/obo/GO_0010506) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0010506" -### primordial vasculature `http://purl.obolibrary.org/obo/UBERON_0014903` -#### Removed -- [primordial vasculature](http://purl.obolibrary.org/obo/UBERON_0014903) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [regulation of autophagy](http://purl.obolibrary.org/obo/GO_0010506) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" +- [regulation of autophagy](http://purl.obolibrary.org/obo/GO_0010506) [label](http://www.w3.org/2000/01/rdf-schema#label) "regulation of autophagy" +- Class: [regulation of autophagy](http://purl.obolibrary.org/obo/GO_0010506) -### pro-NK cell `http://purl.obolibrary.org/obo/CL_0000825` -#### Removed -- [pro-NK cell](http://purl.obolibrary.org/obo/CL_0000825) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [regulation of autophagy](http://purl.obolibrary.org/obo/GO_0010506) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([regulates](http://purl.obolibrary.org/obo/RO_0002211) some [autophagy](http://purl.obolibrary.org/obo/GO_0006914)) +- [regulation of autophagy](http://purl.obolibrary.org/obo/GO_0010506) SubClassOf [regulation of cellular catabolic process](http://purl.obolibrary.org/obo/GO_0031329) + +- [regulation of autophagy](http://purl.obolibrary.org/obo/GO_0010506) SubClassOf [regulates](http://purl.obolibrary.org/obo/RO_0002211) some [autophagy](http://purl.obolibrary.org/obo/GO_0006914) -### process `http://purl.obolibrary.org/obo/BFO_0000015` -#### Removed -- [process](http://purl.obolibrary.org/obo/BFO_0000015) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "An occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t."@en + +### regulation of calcium ion export across plasma membrane `http://purl.obolibrary.org/obo/GO_1905912` #### Added -- [process](http://purl.obolibrary.org/obo/BFO_0000015) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "An occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t."@en +- [regulation of calcium ion export across plasma membrane](http://purl.obolibrary.org/obo/GO_1905912) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that modulates the frequency, rate or extent of calcium ion export across the plasma membrane." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:BHF_miRNA" -- [process](http://purl.obolibrary.org/obo/BFO_0000015) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "p is a process = Def. p is an occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t. (axiom label in BFO2 Reference: [083-003])"@en + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:BHF" -### proctodeum `http://purl.obolibrary.org/obo/UBERON_0000931` -#### Removed -- [proctodeum](http://purl.obolibrary.org/obo/UBERON_0000931) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:22362515" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GO_REF:0000058" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:rph" -### proenkephalin-B `http://purl.obolibrary.org/obo/PR_000012526` +- [regulation of calcium ion export across plasma membrane](http://purl.obolibrary.org/obo/GO_1905912) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "rph" -#### Added -- [proenkephalin-B](http://purl.obolibrary.org/obo/PR_000012526) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [proenkephalin-B (human)](http://purl.obolibrary.org/obo/PR_P01213) +- [regulation of calcium ion export across plasma membrane](http://purl.obolibrary.org/obo/GO_1905912) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" +- [regulation of calcium ion export across plasma membrane](http://purl.obolibrary.org/obo/GO_1905912) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2017-02-07T13:20:39Z" -### proerythroblast `http://purl.obolibrary.org/obo/CL_0000547` -#### Removed -- [proerythroblast](http://purl.obolibrary.org/obo/CL_0000547) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [regulation of calcium ion export across plasma membrane](http://purl.obolibrary.org/obo/GO_1905912) [label](http://www.w3.org/2000/01/rdf-schema#label) "regulation of calcium ion export across plasma membrane" +- [regulation of calcium ion export across plasma membrane](http://purl.obolibrary.org/obo/GO_1905912) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:1905912" +- [regulation of calcium ion export across plasma membrane](http://purl.obolibrary.org/obo/GO_1905912) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "regulation of calcium ion efflux from cell" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" -### progenitor cell `http://purl.obolibrary.org/obo/CL_0011026` -#### Removed -- [progenitor cell](http://purl.obolibrary.org/obo/CL_0011026) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [regulation of calcium ion export across plasma membrane](http://purl.obolibrary.org/obo/GO_1905912) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "regulation of calcium ion export from cell" +- Class: [regulation of calcium ion export across plasma membrane](http://purl.obolibrary.org/obo/GO_1905912) +- [regulation of calcium ion export across plasma membrane](http://purl.obolibrary.org/obo/GO_1905912) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([regulates](http://purl.obolibrary.org/obo/RO_0002211) some [calcium ion export across plasma membrane](http://purl.obolibrary.org/obo/GO_1990034)) -### programmed cell death protein 1 `http://purl.obolibrary.org/obo/PR_000001919` +- [regulation of calcium ion export across plasma membrane](http://purl.obolibrary.org/obo/GO_1905912) SubClassOf [regulation of calcium ion transmembrane transport](http://purl.obolibrary.org/obo/GO_1903169) -#### Added -- [programmed cell death protein 1](http://purl.obolibrary.org/obo/PR_000001919) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [programmed cell death protein 1 (human)](http://purl.obolibrary.org/obo/PR_Q15116) +- [regulation of calcium ion export across plasma membrane](http://purl.obolibrary.org/obo/GO_1905912) SubClassOf [regulates](http://purl.obolibrary.org/obo/RO_0002211) some [calcium ion export across plasma membrane](http://purl.obolibrary.org/obo/GO_1990034) -### prolactin `http://purl.obolibrary.org/obo/PR_000013246` +### regulation of calcium ion import across plasma membrane `http://purl.obolibrary.org/obo/GO_1905664` #### Added -- [prolactin](http://purl.obolibrary.org/obo/PR_000013246) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [prolactin (human)](http://purl.obolibrary.org/obo/PR_P01236) +- [regulation of calcium ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_1905664) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "bhm" +- [regulation of calcium ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_1905664) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2016-11-11T09:26:06Z" -### prominin-1 `http://purl.obolibrary.org/obo/PR_000001786` +- [regulation of calcium ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_1905664) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" -#### Added -- [prominin-1](http://purl.obolibrary.org/obo/PR_000001786) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [prominin-1 (human)](http://purl.obolibrary.org/obo/PR_O43490) +- [regulation of calcium ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_1905664) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that modulates the frequency, rate or extent of calcium ion import across plasma membrane." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:17640527" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:bhm" -### promonocyte `http://purl.obolibrary.org/obo/CL_0000559` -#### Removed -- [promonocyte](http://purl.obolibrary.org/obo/CL_0000559) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GO_REF:0000058" +- [regulation of calcium ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_1905664) [label](http://www.w3.org/2000/01/rdf-schema#label) "regulation of calcium ion import across plasma membrane" -### promyelocyte `http://purl.obolibrary.org/obo/CL_0000836` -#### Removed -- [promyelocyte](http://purl.obolibrary.org/obo/CL_0000836) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [regulation of calcium ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_1905664) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "An example of this is PPP3CA in human (Q08209) in 17640527 (inferred from direct assay)." +- [regulation of calcium ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_1905664) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:1905664" +- Class: [regulation of calcium ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_1905664) -### prostate epithelial cord `http://purl.obolibrary.org/obo/UBERON_0009843` -#### Removed -- [prostate epithelial cord](http://purl.obolibrary.org/obo/UBERON_0009843) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [regulation of calcium ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_1905664) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([regulates](http://purl.obolibrary.org/obo/RO_0002211) some [calcium ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098703)) +- [regulation of calcium ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_1905664) SubClassOf [regulation of calcium ion transmembrane transport](http://purl.obolibrary.org/obo/GO_1903169) +- [regulation of calcium ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_1905664) SubClassOf [regulates](http://purl.obolibrary.org/obo/RO_0002211) some [calcium ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098703) -### prostate field `http://purl.obolibrary.org/obo/UBERON_0009847` -#### Removed -- [prostate field](http://purl.obolibrary.org/obo/UBERON_0009847) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +### regulation of cell morphogenesis involved in differentiation `http://purl.obolibrary.org/obo/GO_0010769` +#### Removed +- [regulation of cell morphogenesis involved in differentiation](http://purl.obolibrary.org/obo/GO_0010769) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that modulates the frequency, rate or extent of cell morphogenesis contributing to cell differentiation. Cell morphogenesis involved in differentiation is the change in form (cell shape and size) that occurs when relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dph" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:tb" -### prostate glandular acinus `http://purl.obolibrary.org/obo/UBERON_0004179` -#### Removed -- [prostate glandular acinus](http://purl.obolibrary.org/obo/UBERON_0004179) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [regulation of cell morphogenesis involved in differentiation](http://purl.obolibrary.org/obo/GO_0010769) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" +- [regulation of cell morphogenesis involved in differentiation](http://purl.obolibrary.org/obo/GO_0010769) [label](http://www.w3.org/2000/01/rdf-schema#label) "regulation of cell morphogenesis involved in differentiation" +- [regulation of cell morphogenesis involved in differentiation](http://purl.obolibrary.org/obo/GO_0010769) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0010769" -### protein c-Fos `http://purl.obolibrary.org/obo/PR_000007597` +- Class: [regulation of cell morphogenesis involved in differentiation](http://purl.obolibrary.org/obo/GO_0010769) -#### Added -- [protein c-Fos](http://purl.obolibrary.org/obo/PR_000007597) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [protein c-Fos (human)](http://purl.obolibrary.org/obo/PR_P01100) +- [regulation of cell morphogenesis involved in differentiation](http://purl.obolibrary.org/obo/GO_0010769) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([regulates](http://purl.obolibrary.org/obo/RO_0002211) some [cell morphogenesis involved in differentiation](http://purl.obolibrary.org/obo/GO_0000904)) +- [regulation of cell morphogenesis involved in differentiation](http://purl.obolibrary.org/obo/GO_0010769) SubClassOf [regulates](http://purl.obolibrary.org/obo/RO_0002211) some [cell morphogenesis involved in differentiation](http://purl.obolibrary.org/obo/GO_0000904) -### pulmonary capillary endothelial cell `http://purl.obolibrary.org/obo/CL_4028001` +- [regulation of cell morphogenesis involved in differentiation](http://purl.obolibrary.org/obo/GO_0010769) SubClassOf [regulation of cell morphogenesis](http://purl.obolibrary.org/obo/GO_0022604) -#### Added -- [pulmonary capillary endothelial cell](http://purl.obolibrary.org/obo/CL_4028001) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [pulmonary capillary](http://purl.obolibrary.org/obo/UBERON_0016405) -### pulmonary lymphatic vessel `http://purl.obolibrary.org/obo/UBERON_0018227` +### regulation of cell projection organization `http://purl.obolibrary.org/obo/GO_0031344` #### Added -- [pulmonary lymphatic vessel](http://purl.obolibrary.org/obo/UBERON_0018227) SubClassOf [has part](http://purl.obolibrary.org/obo/BFO_0000051) some [respiratory system lymphatic vessel endothelium](http://purl.obolibrary.org/obo/UBERON_0003529) +- [regulation of cell projection organization](http://purl.obolibrary.org/obo/GO_0031344) SubClassOf [regulation of cell population proliferation](http://purl.obolibrary.org/obo/GO_0042127) -- [pulmonary lymphatic vessel](http://purl.obolibrary.org/obo/UBERON_0018227) SubClassOf [protein-containing material entity](http://purl.obolibrary.org/obo/PR_000050567) - -### pulmonary part of lymphatic system `http://purl.obolibrary.org/obo/UBERON_0018226` -#### Removed -- [pulmonary part of lymphatic system](http://purl.obolibrary.org/obo/UBERON_0018226) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +### regulation of cytoplasmic translation `http://purl.obolibrary.org/obo/GO_2000765` #### Added -- [pulmonary part of lymphatic system](http://purl.obolibrary.org/obo/UBERON_0018226) SubClassOf [protein-containing material entity](http://purl.obolibrary.org/obo/PR_000050567) +- [regulation of cytoplasmic translation](http://purl.obolibrary.org/obo/GO_2000765) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "vw" +- [regulation of cytoplasmic translation](http://purl.obolibrary.org/obo/GO_2000765) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2011-06-20T10:39:19Z" -### pulmonary vascular system `http://purl.obolibrary.org/obo/UBERON_0008886` -#### Removed -- [pulmonary vascular system](http://purl.obolibrary.org/obo/UBERON_0008886) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [regulation of cytoplasmic translation](http://purl.obolibrary.org/obo/GO_2000765) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" +- [regulation of cytoplasmic translation](http://purl.obolibrary.org/obo/GO_2000765) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that modulates the frequency, rate or extent of cytoplasmic translation." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:obol" +- [regulation of cytoplasmic translation](http://purl.obolibrary.org/obo/GO_2000765) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:2000765" -### pvalb GABAergic cortical interneuron `http://purl.obolibrary.org/obo/CL_4023018` +- [regulation of cytoplasmic translation](http://purl.obolibrary.org/obo/GO_2000765) [label](http://www.w3.org/2000/01/rdf-schema#label) "regulation of cytoplasmic translation" -#### Added -- [pvalb GABAergic cortical interneuron](http://purl.obolibrary.org/obo/CL_4023018) [symbol](http://purl.obolibrary.org/obo/IAO_0000028) "pvalb cortical interneuron" +- Class: [regulation of cytoplasmic translation](http://purl.obolibrary.org/obo/GO_2000765) +- [regulation of cytoplasmic translation](http://purl.obolibrary.org/obo/GO_2000765) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([regulates](http://purl.obolibrary.org/obo/RO_0002211) some [cytoplasmic translation](http://purl.obolibrary.org/obo/GO_0002181)) -### pyloric antrum `http://purl.obolibrary.org/obo/UBERON_0001165` -#### Removed -- [pyloric antrum](http://purl.obolibrary.org/obo/UBERON_0001165) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [regulation of cytoplasmic translation](http://purl.obolibrary.org/obo/GO_2000765) SubClassOf [regulation of translation](http://purl.obolibrary.org/obo/GO_0006417) +- [regulation of cytoplasmic translation](http://purl.obolibrary.org/obo/GO_2000765) SubClassOf [regulates](http://purl.obolibrary.org/obo/RO_0002211) some [cytoplasmic translation](http://purl.obolibrary.org/obo/GO_0002181) -### pylorus `http://purl.obolibrary.org/obo/UBERON_0001166` -#### Removed -- [pylorus](http://purl.obolibrary.org/obo/UBERON_0001166) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +### regulation of cytoplasmic translational elongation `http://purl.obolibrary.org/obo/GO_1900247` +#### Added +- [regulation of cytoplasmic translational elongation](http://purl.obolibrary.org/obo/GO_1900247) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:1900247" +- [regulation of cytoplasmic translational elongation](http://purl.obolibrary.org/obo/GO_1900247) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" -### ready for release `http://purl.obolibrary.org/obo/IAO_0000122` +- [regulation of cytoplasmic translational elongation](http://purl.obolibrary.org/obo/GO_1900247) [label](http://www.w3.org/2000/01/rdf-schema#label) "regulation of cytoplasmic translational elongation" -#### Added -- [ready for release](http://purl.obolibrary.org/obo/IAO_0000122) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "ready for release"@en +- [regulation of cytoplasmic translational elongation](http://purl.obolibrary.org/obo/GO_1900247) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2012-04-03T05:07:02Z" -- [ready for release](http://purl.obolibrary.org/obo/IAO_0000122) [label](http://www.w3.org/2000/01/rdf-schema#label) "ready for release"@en +- [regulation of cytoplasmic translational elongation](http://purl.obolibrary.org/obo/GO_1900247) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "vw" -- [ready for release](http://purl.obolibrary.org/obo/IAO_0000122) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Class has undergone final review, is ready for use, and will be included in the next release. Any class lacking "ready_for_release" should be considered likely to change place in hierarchy, have its definition refined, or be obsoleted in the next release. Those classes deemed "ready_for_release" will also derived from a chain of ancestor classes that are also "ready_for_release.""@en +- [regulation of cytoplasmic translational elongation](http://purl.obolibrary.org/obo/GO_1900247) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that modulates the frequency, rate or extent of cytoplasmic translational elongation." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" -- Individual: [ready for release](http://purl.obolibrary.org/obo/IAO_0000122) +- Class: [regulation of cytoplasmic translational elongation](http://purl.obolibrary.org/obo/GO_1900247) +- [regulation of cytoplasmic translational elongation](http://purl.obolibrary.org/obo/GO_1900247) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([regulates](http://purl.obolibrary.org/obo/RO_0002211) some [cytoplasmic translational elongation](http://purl.obolibrary.org/obo/GO_0002182)) -### receptor-type tyrosine-protein kinase FLT3 `http://purl.obolibrary.org/obo/PR_000002001` +- [regulation of cytoplasmic translational elongation](http://purl.obolibrary.org/obo/GO_1900247) SubClassOf [regulates](http://purl.obolibrary.org/obo/RO_0002211) some [cytoplasmic translational elongation](http://purl.obolibrary.org/obo/GO_0002182) -#### Added -- [receptor-type tyrosine-protein kinase FLT3](http://purl.obolibrary.org/obo/PR_000002001) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [receptor-type tyrosine-protein kinase FLT3 (human)](http://purl.obolibrary.org/obo/PR_P36888) +- [regulation of cytoplasmic translational elongation](http://purl.obolibrary.org/obo/GO_1900247) SubClassOf [regulation of translational elongation](http://purl.obolibrary.org/obo/GO_0006448) -### receptor-type tyrosine-protein phosphatase C `http://purl.obolibrary.org/obo/PR_000001006` +### regulation of cytoplasmic translational initiation `http://purl.obolibrary.org/obo/GO_1904688` #### Added -- [receptor-type tyrosine-protein phosphatase C](http://purl.obolibrary.org/obo/PR_000001006) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [receptor-type tyrosine-protein phosphatase C (human)](http://purl.obolibrary.org/obo/PR_P08575) +- [regulation of cytoplasmic translational initiation](http://purl.obolibrary.org/obo/GO_1904688) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that modulates the frequency, rate or extent of cytoplasmic translational initiation." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:12242291" -### receptor-type tyrosine-protein phosphatase C isoform CD45RA `http://purl.obolibrary.org/obo/PR_000001015` + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GO_REF:0000058" -#### Added -- [receptor-type tyrosine-protein phosphatase C isoform CD45RA](http://purl.obolibrary.org/obo/PR_000001015) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [receptor-type tyrosine-protein phosphatase C isoform CD45RA (human)](http://purl.obolibrary.org/obo/PR_P08575-8) +- [regulation of cytoplasmic translational initiation](http://purl.obolibrary.org/obo/GO_1904688) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "dos" +- [regulation of cytoplasmic translational initiation](http://purl.obolibrary.org/obo/GO_1904688) [term tracker item](http://purl.obolibrary.org/obo/IAO_0000233) "https://github.com/geneontology/go-ontology/issues/21560"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI) -### receptor-type tyrosine-protein phosphatase C isoform CD45RABC `http://purl.obolibrary.org/obo/PR_000001014` +- [regulation of cytoplasmic translational initiation](http://purl.obolibrary.org/obo/GO_1904688) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2015-09-25T14:39:38Z" -#### Added -- [receptor-type tyrosine-protein phosphatase C isoform CD45RABC](http://purl.obolibrary.org/obo/PR_000001014) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [receptor-type tyrosine-protein phosphatase C isoform CD45RABC (human)](http://purl.obolibrary.org/obo/PR_P08575-3) +- [regulation of cytoplasmic translational initiation](http://purl.obolibrary.org/obo/GO_1904688) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:1904688" +- [regulation of cytoplasmic translational initiation](http://purl.obolibrary.org/obo/GO_1904688) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" -### receptor-type tyrosine-protein phosphatase C isoform CD45RO `http://purl.obolibrary.org/obo/PR_000001017` +- [regulation of cytoplasmic translational initiation](http://purl.obolibrary.org/obo/GO_1904688) [label](http://www.w3.org/2000/01/rdf-schema#label) "regulation of cytoplasmic translational initiation" -#### Added -- [receptor-type tyrosine-protein phosphatase C isoform CD45RO](http://purl.obolibrary.org/obo/PR_000001017) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [receptor-type tyrosine-protein phosphatase C isoform CD45RO (human)](http://purl.obolibrary.org/obo/PR_P08575-4) +- Class: [regulation of cytoplasmic translational initiation](http://purl.obolibrary.org/obo/GO_1904688) +- [regulation of cytoplasmic translational initiation](http://purl.obolibrary.org/obo/GO_1904688) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([regulates](http://purl.obolibrary.org/obo/RO_0002211) some [cytoplasmic translational initiation](http://purl.obolibrary.org/obo/GO_0002183)) -### rectal lumen `http://purl.obolibrary.org/obo/UBERON_0009670` -#### Removed -- [rectal lumen](http://purl.obolibrary.org/obo/UBERON_0009670) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [regulation of cytoplasmic translational initiation](http://purl.obolibrary.org/obo/GO_1904688) SubClassOf [regulation of translational initiation](http://purl.obolibrary.org/obo/GO_0006446) +- [regulation of cytoplasmic translational initiation](http://purl.obolibrary.org/obo/GO_1904688) SubClassOf [regulates](http://purl.obolibrary.org/obo/RO_0002211) some [cytoplasmic translational initiation](http://purl.obolibrary.org/obo/GO_0002183) +- [regulation of cytoplasmic translational initiation](http://purl.obolibrary.org/obo/GO_1904688) SubClassOf [regulation of cytoplasmic translation](http://purl.obolibrary.org/obo/GO_2000765) -### red pulp of spleen `http://purl.obolibrary.org/obo/UBERON_0001250` -#### Removed -- [red pulp of spleen](http://purl.obolibrary.org/obo/UBERON_0001250) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +### regulation of cytoplasmic translational termination `http://purl.obolibrary.org/obo/GO_1990580` + +#### Added +- [regulation of cytoplasmic translational termination](http://purl.obolibrary.org/obo/GO_1990580) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "vw" +- [regulation of cytoplasmic translational termination](http://purl.obolibrary.org/obo/GO_1990580) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" -### reelin `http://purl.obolibrary.org/obo/PR_000013879` +- [regulation of cytoplasmic translational termination](http://purl.obolibrary.org/obo/GO_1990580) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2014-12-10T15:48:55Z" -#### Added -- [reelin](http://purl.obolibrary.org/obo/PR_000013879) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [reelin (human)](http://purl.obolibrary.org/obo/PR_P78509) +- [regulation of cytoplasmic translational termination](http://purl.obolibrary.org/obo/GO_1990580) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that modulates the frequency, rate or extent of cytoplasmic translational termination." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:11570975" +- [regulation of cytoplasmic translational termination](http://purl.obolibrary.org/obo/GO_1990580) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:1990580" -### regional part of brain `http://purl.obolibrary.org/obo/UBERON_0002616` -#### Removed -- [regional part of brain](http://purl.obolibrary.org/obo/UBERON_0002616) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [regulation of cytoplasmic translational termination](http://purl.obolibrary.org/obo/GO_1990580) [label](http://www.w3.org/2000/01/rdf-schema#label) "regulation of cytoplasmic translational termination" +- Class: [regulation of cytoplasmic translational termination](http://purl.obolibrary.org/obo/GO_1990580) +- [regulation of cytoplasmic translational termination](http://purl.obolibrary.org/obo/GO_1990580) EquivalentTo [regulation of biological process](http://purl.obolibrary.org/obo/GO_0050789) and ([regulates](http://purl.obolibrary.org/obo/RO_0002211) some [cytoplasmic translational termination](http://purl.obolibrary.org/obo/GO_0002184)) -### regular connective tissue `http://purl.obolibrary.org/obo/UBERON_0007845` -#### Removed -- [regular connective tissue](http://purl.obolibrary.org/obo/UBERON_0007845) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [regulation of cytoplasmic translational termination](http://purl.obolibrary.org/obo/GO_1990580) SubClassOf [regulation of cytoplasmic translation](http://purl.obolibrary.org/obo/GO_2000765) +- [regulation of cytoplasmic translational termination](http://purl.obolibrary.org/obo/GO_1990580) SubClassOf [regulates](http://purl.obolibrary.org/obo/RO_0002211) some [cytoplasmic translational termination](http://purl.obolibrary.org/obo/GO_0002184) +- [regulation of cytoplasmic translational termination](http://purl.obolibrary.org/obo/GO_1990580) SubClassOf [regulation of translational termination](http://purl.obolibrary.org/obo/GO_0006449) -### relaxin receptor 1 `http://purl.obolibrary.org/obo/PR_000001666` + +### regulation of cytoplasmic transport `http://purl.obolibrary.org/obo/GO_1903649` #### Added -- [relaxin receptor 1](http://purl.obolibrary.org/obo/PR_000001666) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [relaxin receptor 1 (human)](http://purl.obolibrary.org/obo/PR_Q9HBX9) +- [regulation of cytoplasmic transport](http://purl.obolibrary.org/obo/GO_1903649) [label](http://www.w3.org/2000/01/rdf-schema#label) "regulation of cytoplasmic transport" +- [regulation of cytoplasmic transport](http://purl.obolibrary.org/obo/GO_1903649) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "jl" -### renal lobule `http://purl.obolibrary.org/obo/UBERON_0009914` -#### Removed -- [renal lobule](http://purl.obolibrary.org/obo/UBERON_0009914) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [regulation of cytoplasmic transport](http://purl.obolibrary.org/obo/GO_1903649) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:1903649" +- [regulation of cytoplasmic transport](http://purl.obolibrary.org/obo/GO_1903649) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" +- [regulation of cytoplasmic transport](http://purl.obolibrary.org/obo/GO_1903649) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "regulation of cytoplasmic streaming" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" -### renal vesicle `http://purl.obolibrary.org/obo/UBERON_0004209` -#### Removed -- [renal vesicle](http://purl.obolibrary.org/obo/UBERON_0004209) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [regulation of cytoplasmic transport](http://purl.obolibrary.org/obo/GO_1903649) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that modulates the frequency, rate or extent of cytoplasmic transport." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:25049409" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GO_REF:0000058" -### renin `http://purl.obolibrary.org/obo/PR_000013883` +- [regulation of cytoplasmic transport](http://purl.obolibrary.org/obo/GO_1903649) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2014-11-24T13:38:17Z" -#### Added -- [renin](http://purl.obolibrary.org/obo/PR_000013883) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [renin (human)](http://purl.obolibrary.org/obo/PR_P00797) +- Class: [regulation of cytoplasmic transport](http://purl.obolibrary.org/obo/GO_1903649) +- [regulation of cytoplasmic transport](http://purl.obolibrary.org/obo/GO_1903649) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([regulates](http://purl.obolibrary.org/obo/RO_0002211) some [cytosolic transport](http://purl.obolibrary.org/obo/GO_0016482)) -### reproductive system `http://purl.obolibrary.org/obo/UBERON_0000990` -#### Removed -- [reproductive system](http://purl.obolibrary.org/obo/UBERON_0000990) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [regulation of cytoplasmic transport](http://purl.obolibrary.org/obo/GO_1903649) SubClassOf [regulation of intracellular transport](http://purl.obolibrary.org/obo/GO_0032386) +- [regulation of cytoplasmic transport](http://purl.obolibrary.org/obo/GO_1903649) SubClassOf [regulates](http://purl.obolibrary.org/obo/RO_0002211) some [cytosolic transport](http://purl.obolibrary.org/obo/GO_0016482) -### requires discussion `http://purl.obolibrary.org/obo/IAO_0000428` +### regulation of dense core granule transport `http://purl.obolibrary.org/obo/GO_1904809` #### Added -- [requires discussion](http://purl.obolibrary.org/obo/IAO_0000428) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A term that is metadata complete, has been reviewed, and problems have been identified that require discussion before release. Such a term requires editor note(s) to identify the outstanding issues."@en - -- [requires discussion](http://purl.obolibrary.org/obo/IAO_0000428) [IAO_0000119](http://purl.obolibrary.org/obo/IAO_0000119) "group:OBI"@en +- [regulation of dense core granule transport](http://purl.obolibrary.org/obo/GO_1904809) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "cdk-5 in C.elegans (G5ECH7) in PMID:22699897 (inferred from mutant phenotype)." -- [requires discussion](http://purl.obolibrary.org/obo/IAO_0000428) [label](http://www.w3.org/2000/01/rdf-schema#label) "requires discussion"@en +- [regulation of dense core granule transport](http://purl.obolibrary.org/obo/GO_1904809) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" -- [requires discussion](http://purl.obolibrary.org/obo/IAO_0000428) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "requires discussion"@en +- [regulation of dense core granule transport](http://purl.obolibrary.org/obo/GO_1904809) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "es" -- [requires discussion](http://purl.obolibrary.org/obo/IAO_0000428) [IAO_0000117](http://purl.obolibrary.org/obo/IAO_0000117) "Alan Ruttenberg"@en +- [regulation of dense core granule transport](http://purl.obolibrary.org/obo/GO_1904809) [label](http://www.w3.org/2000/01/rdf-schema#label) "regulation of dense core granule transport" -- Individual: [requires discussion](http://purl.obolibrary.org/obo/IAO_0000428) +- [regulation of dense core granule transport](http://purl.obolibrary.org/obo/GO_1904809) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:1904809" +- [regulation of dense core granule transport](http://purl.obolibrary.org/obo/GO_1904809) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that modulates the frequency, rate or extent of dense core granule transport." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:22699897" -### respiratory primordium `http://purl.obolibrary.org/obo/UBERON_0008947` -#### Removed -- [respiratory primordium](http://purl.obolibrary.org/obo/UBERON_0008947) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GO_REF:0000058" +- [regulation of dense core granule transport](http://purl.obolibrary.org/obo/GO_1904809) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "regulation of dense core vesicle transport" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" -### respiratory primordium mesenchyme `http://purl.obolibrary.org/obo/UBERON_0036073` -#### Removed -- [respiratory primordium mesenchyme](http://purl.obolibrary.org/obo/UBERON_0036073) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [regulation of dense core granule transport](http://purl.obolibrary.org/obo/GO_1904809) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2015-11-11T10:40:10Z" +- Class: [regulation of dense core granule transport](http://purl.obolibrary.org/obo/GO_1904809) +- [regulation of dense core granule transport](http://purl.obolibrary.org/obo/GO_1904809) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([regulates](http://purl.obolibrary.org/obo/RO_0002211) some [dense core granule transport](http://purl.obolibrary.org/obo/GO_1901950)) -### results in acquisition of features of `http://purl.obolibrary.org/obo/RO_0002315` -#### Removed -- [results in acquisition of features of](http://purl.obolibrary.org/obo/RO_0002315) Range [connected anatomical structure](http://purl.obolibrary.org/obo/CARO_0000003) +- [regulation of dense core granule transport](http://purl.obolibrary.org/obo/GO_1904809) SubClassOf [regulates](http://purl.obolibrary.org/obo/RO_0002211) some [dense core granule transport](http://purl.obolibrary.org/obo/GO_1901950) -#### Added -- [results in acquisition of features of](http://purl.obolibrary.org/obo/RO_0002315) Range [anatomical structure](http://purl.obolibrary.org/obo/UBERON_0000061) +- [regulation of dense core granule transport](http://purl.obolibrary.org/obo/GO_1904809) SubClassOf [regulation of cytoplasmic transport](http://purl.obolibrary.org/obo/GO_1903649) -### results in developmental progression of `http://purl.obolibrary.org/obo/RO_0002295` +### regulation of gene expression `http://purl.obolibrary.org/obo/GO_0010468` #### Removed -- [results in developmental progression of](http://purl.obolibrary.org/obo/RO_0002295) Range [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [regulation of gene expression](http://purl.obolibrary.org/obo/GO_0010468) SubClassOf [regulation of macromolecule metabolic process](http://purl.obolibrary.org/obo/GO_0060255) #### Added -- [results in developmental progression of](http://purl.obolibrary.org/obo/RO_0002295) Range [anatomical entity](http://purl.obolibrary.org/obo/UBERON_0001062) +- [regulation of gene expression](http://purl.obolibrary.org/obo/GO_0010468) SubClassOf [regulation of macromolecule biosynthetic process](http://purl.obolibrary.org/obo/GO_0010556) -### results in fusion of `http://purl.obolibrary.org/obo/RO_0012008` -#### Removed -- [results in fusion of](http://purl.obolibrary.org/obo/RO_0012008) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "pg" +### regulation of glycine import across plasma membrane `http://purl.obolibrary.org/obo/GO_1900923` #### Added -- [results in fusion of](http://purl.obolibrary.org/obo/RO_0012008) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) [0000-0003-1813-6857](https://orcid.org/0000-0003-1813-6857) +- [regulation of glycine import across plasma membrane](http://purl.obolibrary.org/obo/GO_1900923) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" +- [regulation of glycine import across plasma membrane](http://purl.obolibrary.org/obo/GO_1900923) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that modulates the frequency, rate or extent of glycine import into a cell." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" -### reticulocyte `http://purl.obolibrary.org/obo/CL_0000558` -#### Removed -- [reticulocyte](http://purl.obolibrary.org/obo/CL_0000558) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) - +- [regulation of glycine import across plasma membrane](http://purl.obolibrary.org/obo/GO_1900923) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "al" +- [regulation of glycine import across plasma membrane](http://purl.obolibrary.org/obo/GO_1900923) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "regulation of glycine import" -### reticulospinal neuron `http://purl.obolibrary.org/obo/CL_4023107` -#### Removed -- [reticulospinal neuron](http://purl.obolibrary.org/obo/CL_4023107) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [regulation of glycine import across plasma membrane](http://purl.obolibrary.org/obo/GO_1900923) [label](http://www.w3.org/2000/01/rdf-schema#label) "regulation of glycine import across plasma membrane" +- [regulation of glycine import across plasma membrane](http://purl.obolibrary.org/obo/GO_1900923) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:1900923" +- [regulation of glycine import across plasma membrane](http://purl.obolibrary.org/obo/GO_1900923) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2012-06-13T07:40:11Z" -### retina horizontal cell `http://purl.obolibrary.org/obo/CL_0000745` -#### Removed -- [retina horizontal cell](http://purl.obolibrary.org/obo/CL_0000745) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- Class: [regulation of glycine import across plasma membrane](http://purl.obolibrary.org/obo/GO_1900923) -#### Added -- [retina horizontal cell](http://purl.obolibrary.org/obo/CL_0000745) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "HCs" - - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation) +- [regulation of glycine import across plasma membrane](http://purl.obolibrary.org/obo/GO_1900923) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([regulates](http://purl.obolibrary.org/obo/RO_0002211) some [glycine import across plasma membrane](http://purl.obolibrary.org/obo/GO_1903804)) - - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [plural term](http://purl.obolibrary.org/obo/uberon#PLURAL) +- [regulation of glycine import across plasma membrane](http://purl.obolibrary.org/obo/GO_1900923) SubClassOf [regulates](http://purl.obolibrary.org/obo/RO_0002211) some [glycine import across plasma membrane](http://purl.obolibrary.org/obo/GO_1903804) - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1038/s41598-020-66092-9" +- [regulation of glycine import across plasma membrane](http://purl.obolibrary.org/obo/GO_1900923) SubClassOf [regulation of amino acid import across plasma membrane](http://purl.obolibrary.org/obo/GO_0010958) -- [retina horizontal cell](http://purl.obolibrary.org/obo/CL_0000745) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "HC" - - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation) - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1038/s41598-020-66092-9" +### regulation of histamine uptake `http://purl.obolibrary.org/obo/GO_0051616` +#### Added +- [regulation of histamine uptake](http://purl.obolibrary.org/obo/GO_0051616) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0051616" -### retinal bipolar neuron `http://purl.obolibrary.org/obo/CL_0000748` -#### Removed -- [retinal bipolar neuron](http://purl.obolibrary.org/obo/CL_0000748) EquivalentTo [bipolar neuron](http://purl.obolibrary.org/obo/CL_0000103) and ([has soma location](http://purl.obolibrary.org/obo/RO_0002100) some [retina](http://purl.obolibrary.org/obo/UBERON_0000966)) +- [regulation of histamine uptake](http://purl.obolibrary.org/obo/GO_0051616) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" -- [retinal bipolar neuron](http://purl.obolibrary.org/obo/CL_0000748) SubClassOf [has soma location](http://purl.obolibrary.org/obo/RO_0002100) some [retina](http://purl.obolibrary.org/obo/UBERON_0000966) +- [regulation of histamine uptake](http://purl.obolibrary.org/obo/GO_0051616) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "regulation of histamine import" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dph" -- [retinal bipolar neuron](http://purl.obolibrary.org/obo/CL_0000748) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:tb" -#### Added -- [retinal bipolar neuron](http://purl.obolibrary.org/obo/CL_0000748) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "BCs" - - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation) +- [regulation of histamine uptake](http://purl.obolibrary.org/obo/GO_0051616) [label](http://www.w3.org/2000/01/rdf-schema#label) "regulation of histamine uptake" - - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [plural term](http://purl.obolibrary.org/obo/uberon#PLURAL) +- [regulation of histamine uptake](http://purl.obolibrary.org/obo/GO_0051616) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that modulates the frequency, rate or extent of the directed movement of the neurotransmitter histamine into a cell." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:ai" - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1038/s41598-020-66092-9" +- Class: [regulation of histamine uptake](http://purl.obolibrary.org/obo/GO_0051616) -- [retinal bipolar neuron](http://purl.obolibrary.org/obo/CL_0000748) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "BC" - - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation) +- [regulation of histamine uptake](http://purl.obolibrary.org/obo/GO_0051616) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([regulates](http://purl.obolibrary.org/obo/RO_0002211) some [histamine uptake](http://purl.obolibrary.org/obo/GO_0051615)) - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1038/s41598-020-66092-9" +- [regulation of histamine uptake](http://purl.obolibrary.org/obo/GO_0051616) SubClassOf [regulation of neurotransmitter uptake](http://purl.obolibrary.org/obo/GO_0051580) -- [retinal bipolar neuron](http://purl.obolibrary.org/obo/CL_0000748) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "BPs" - - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation) +- [regulation of histamine uptake](http://purl.obolibrary.org/obo/GO_0051616) SubClassOf [regulates](http://purl.obolibrary.org/obo/RO_0002211) some [histamine uptake](http://purl.obolibrary.org/obo/GO_0051615) - - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [plural term](http://purl.obolibrary.org/obo/uberon#PLURAL) - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GSE137537" +### regulation of iron export across plasma membrane `http://purl.obolibrary.org/obo/GO_1904038` -- [retinal bipolar neuron](http://purl.obolibrary.org/obo/CL_0000748) EquivalentTo [bipolar neuron](http://purl.obolibrary.org/obo/CL_0000103) and ([has soma location](http://purl.obolibrary.org/obo/RO_0002100) some [inner nuclear layer of retina](http://purl.obolibrary.org/obo/UBERON_0001791)) +#### Added +- [regulation of iron export across plasma membrane](http://purl.obolibrary.org/obo/GO_1904038) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" -- [retinal bipolar neuron](http://purl.obolibrary.org/obo/CL_0000748) SubClassOf [has soma location](http://purl.obolibrary.org/obo/RO_0002100) some [inner nuclear layer of retina](http://purl.obolibrary.org/obo/UBERON_0001791) +- [regulation of iron export across plasma membrane](http://purl.obolibrary.org/obo/GO_1904038) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that modulates the frequency, rate or extent of export of iron ions from inside of a cell, across the plasma membrane and into the extracellular region." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:15514116" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:kom" -### retinal cone cell `http://purl.obolibrary.org/obo/CL_0000573` + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" -#### Added -- [retinal cone cell](http://purl.obolibrary.org/obo/CL_0000573) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "cone" - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1038/s41598-020-66092-9" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:BHF" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GO_REF:0000058" -### retinal ganglion cell `http://purl.obolibrary.org/obo/CL_0000740` -#### Removed -- [retinal ganglion cell](http://purl.obolibrary.org/obo/CL_0000740) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "RGC" +- [regulation of iron export across plasma membrane](http://purl.obolibrary.org/obo/GO_1904038) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:1904038" -#### Added -- [retinal ganglion cell](http://purl.obolibrary.org/obo/CL_0000740) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "RGCs" - - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation) +- [regulation of iron export across plasma membrane](http://purl.obolibrary.org/obo/GO_1904038) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "kom" - - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [plural term](http://purl.obolibrary.org/obo/uberon#PLURAL) +- [regulation of iron export across plasma membrane](http://purl.obolibrary.org/obo/GO_1904038) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "regulation of ferrous iron export" - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1038/s41598-020-66092-9" +- [regulation of iron export across plasma membrane](http://purl.obolibrary.org/obo/GO_1904038) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "regulation of iron(2+) export" -- [retinal ganglion cell](http://purl.obolibrary.org/obo/CL_0000740) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "RGC" - - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation) +- [regulation of iron export across plasma membrane](http://purl.obolibrary.org/obo/GO_1904038) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2015-03-16T15:36:37Z" - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1038/s41598-020-66092-9" +- [regulation of iron export across plasma membrane](http://purl.obolibrary.org/obo/GO_1904038) [label](http://www.w3.org/2000/01/rdf-schema#label) "regulation of iron export across plasma membrane" +- Class: [regulation of iron export across plasma membrane](http://purl.obolibrary.org/obo/GO_1904038) -### retinal neural layer `http://purl.obolibrary.org/obo/UBERON_0003902` -#### Removed -- [retinal neural layer](http://purl.obolibrary.org/obo/UBERON_0003902) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [regulation of iron export across plasma membrane](http://purl.obolibrary.org/obo/GO_1904038) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([regulates](http://purl.obolibrary.org/obo/RO_0002211) some [iron ion export across plasma membrane](http://purl.obolibrary.org/obo/GO_1903988)) +- [regulation of iron export across plasma membrane](http://purl.obolibrary.org/obo/GO_1904038) SubClassOf [regulates](http://purl.obolibrary.org/obo/RO_0002211) some [iron ion export across plasma membrane](http://purl.obolibrary.org/obo/GO_1903988) +- [regulation of iron export across plasma membrane](http://purl.obolibrary.org/obo/GO_1904038) SubClassOf [regulation of iron ion transmembrane transport](http://purl.obolibrary.org/obo/GO_0034759) -### retinal progenitor cell `http://purl.obolibrary.org/obo/CL_0002672` -#### Removed -- [retinal progenitor cell](http://purl.obolibrary.org/obo/CL_0002672) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +### regulation of iron ion import across plasma membrane `http://purl.obolibrary.org/obo/GO_1904438` +#### Added +- [regulation of iron ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_1904438) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "regulation of ferrous ion import into cell" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" -### retinal rod cell `http://purl.obolibrary.org/obo/CL_0000604` +- [regulation of iron ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_1904438) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" -#### Added -- [retinal rod cell](http://purl.obolibrary.org/obo/CL_0000604) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "rod" - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1038/s41598-020-66092-9" +- [regulation of iron ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_1904438) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "rl" +- [regulation of iron ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_1904438) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2015-03-04T14:37:36Z" -### retrotrapezoid nucleus neuron `http://purl.obolibrary.org/obo/CL_1000001` -#### Removed -- [retrotrapezoid nucleus neuron](http://purl.obolibrary.org/obo/CL_1000001) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [regulation of iron ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_1904438) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that modulates the frequency, rate or extent of iron ions import across plasma membrane." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:kom" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:18353247" -### rhombomere 1 `http://purl.obolibrary.org/obo/UBERON_0005499` + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:BHF" -#### Added -- [rhombomere 1](http://purl.obolibrary.org/obo/UBERON_0005499) [UBPROP_0000001](http://purl.obolibrary.org/obo/UBPROP_0000001) "Hindbrain segment or neuromere. Kimmel et al, 1995.[TAO]" - - [source](http://www.geneontology.org/formats/oboInOwl#source) "ZFIN:curator" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GO_REF:0000058" - - [external_class](http://www.geneontology.org/formats/oboInOwl#external_class) "TAO:0001031" +- [regulation of iron ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_1904438) [label](http://www.w3.org/2000/01/rdf-schema#label) "regulation of iron ion import across plasma membrane" - - [ontology](http://www.geneontology.org/formats/oboInOwl#ontology) "TAO" +- [regulation of iron ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_1904438) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "regulation of ferrous iron import into cell" - - [date_retrieved](http://www.geneontology.org/formats/oboInOwl#date_retrieved) "2012-08-14" +- [regulation of iron ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_1904438) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "regulation of ferrous iron import across plasma membrane" -- [rhombomere 1](http://purl.obolibrary.org/obo/UBERON_0005499) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "DMBA:16915" +- [regulation of iron ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_1904438) [has_alternative_id](http://www.geneontology.org/formats/oboInOwl#hasAlternativeId) "GO:1903989" -- [rhombomere 1](http://purl.obolibrary.org/obo/UBERON_0005499) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "r1" - - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [ABBREVIATION](http://purl.obolibrary.org/obo/uberon/core#ABBREVIATION) +- [regulation of iron ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_1904438) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:1904438" - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ZFA:0001031" +- Class: [regulation of iron ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_1904438) -- [rhombomere 1](http://purl.obolibrary.org/obo/UBERON_0005499) [UBPROP_0000111](http://purl.obolibrary.org/obo/UBPROP_0000111) "1"^^[nonNegativeInteger](http://www.w3.org/2001/XMLSchema#nonNegativeInteger) +- [regulation of iron ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_1904438) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([regulates](http://purl.obolibrary.org/obo/RO_0002211) some [iron ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098711)) -- [rhombomere 1](http://purl.obolibrary.org/obo/UBERON_0005499) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "EMAPA:16290" +- [regulation of iron ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_1904438) SubClassOf [regulation of cellular localization](http://purl.obolibrary.org/obo/GO_0060341) -- [rhombomere 1](http://purl.obolibrary.org/obo/UBERON_0005499) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "uberon" +- [regulation of iron ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_1904438) SubClassOf [regulation of iron ion transmembrane transport](http://purl.obolibrary.org/obo/GO_0034759) -- [rhombomere 1](http://purl.obolibrary.org/obo/UBERON_0005499) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [efo_slim](http://purl.obolibrary.org/obo/uberon/core#efo_slim) +- [regulation of iron ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_1904438) SubClassOf [regulates](http://purl.obolibrary.org/obo/RO_0002211) some [iron ion import across plasma membrane](http://purl.obolibrary.org/obo/GO_0098711) -- [rhombomere 1](http://purl.obolibrary.org/obo/UBERON_0005499) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "TAO:0001031" -- [rhombomere 1](http://purl.obolibrary.org/obo/UBERON_0005499) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "EHDAA2:0001637" +### regulation of ligase activity `http://purl.obolibrary.org/obo/GO_0051340` +#### Removed +- [regulation of ligase activity](http://purl.obolibrary.org/obo/GO_0051340) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate) -- [rhombomere 1](http://purl.obolibrary.org/obo/UBERON_0005499) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "FMA:295790" +- [regulation of ligase activity](http://purl.obolibrary.org/obo/GO_0051340) [label](http://www.w3.org/2000/01/rdf-schema#label) "regulation of ligase activity" -- [rhombomere 1](http://purl.obolibrary.org/obo/UBERON_0005499) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "EFO:0003608" +- [regulation of ligase activity](http://purl.obolibrary.org/obo/GO_0051340) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "ligase regulator" -- [rhombomere 1](http://purl.obolibrary.org/obo/UBERON_0005499) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [pheno_slim](http://purl.obolibrary.org/obo/uberon/core#pheno_slim) +- [regulation of ligase activity](http://purl.obolibrary.org/obo/GO_0051340) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that modulates the frequency, rate or extent of ligase activity, the catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:ai" -- [rhombomere 1](http://purl.obolibrary.org/obo/UBERON_0005499) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "DHBA:12667" +- [regulation of ligase activity](http://purl.obolibrary.org/obo/GO_0051340) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0051340" -- [rhombomere 1](http://purl.obolibrary.org/obo/UBERON_0005499) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Hindbrain segment or neuromere 1." - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ZFA:0001031" +- [regulation of ligase activity](http://purl.obolibrary.org/obo/GO_0051340) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" -- [rhombomere 1](http://purl.obolibrary.org/obo/UBERON_0005499) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ZFA:0001031" +- Class: [regulation of ligase activity](http://purl.obolibrary.org/obo/GO_0051340) -- [rhombomere 1](http://purl.obolibrary.org/obo/UBERON_0005499) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [vertebrate_core](http://purl.obolibrary.org/obo/uberon/core#vertebrate_core) +- [regulation of ligase activity](http://purl.obolibrary.org/obo/GO_0051340) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([regulates](http://purl.obolibrary.org/obo/RO_0002211) some [ligase activity](http://purl.obolibrary.org/obo/GO_0016874)) -- [rhombomere 1](http://purl.obolibrary.org/obo/UBERON_0005499) [id](http://www.geneontology.org/formats/oboInOwl#id) "UBERON:0005499" +- [regulation of ligase activity](http://purl.obolibrary.org/obo/GO_0051340) SubClassOf [regulation of catalytic activity](http://purl.obolibrary.org/obo/GO_0050790) -- [rhombomere 1](http://purl.obolibrary.org/obo/UBERON_0005499) [label](http://www.w3.org/2000/01/rdf-schema#label) "rhombomere 1" +- [regulation of ligase activity](http://purl.obolibrary.org/obo/GO_0051340) SubClassOf [regulates](http://purl.obolibrary.org/obo/RO_0002211) some [ligase activity](http://purl.obolibrary.org/obo/GO_0016874) -- Class: [rhombomere 1](http://purl.obolibrary.org/obo/UBERON_0005499) -- [rhombomere 1](http://purl.obolibrary.org/obo/UBERON_0005499) SubClassOf [rhombomere](http://purl.obolibrary.org/obo/UBERON_0001892) -- [rhombomere 1](http://purl.obolibrary.org/obo/UBERON_0005499) SubClassOf [develops from](http://purl.obolibrary.org/obo/RO_0002202) some [presumptive rhombomere 1](http://purl.obolibrary.org/obo/UBERON_0007289) - - [evidence](http://www.geneontology.org/formats/oboInOwl#evidence) "definitional" +### regulation of macroautophagy `http://purl.obolibrary.org/obo/GO_0016241` +#### Removed +- [regulation of macroautophagy](http://purl.obolibrary.org/obo/GO_0016241) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" +- [regulation of macroautophagy](http://purl.obolibrary.org/obo/GO_0016241) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that modulates the frequency, rate or extent of macroautophagy." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:krc" -### rhombomere 1 development `http://purl.obolibrary.org/obo/GO_0021567` +- [regulation of macroautophagy](http://purl.obolibrary.org/obo/GO_0016241) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0016241" -#### Added -- [rhombomere 1 development](http://purl.obolibrary.org/obo/GO_0021567) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0021567" +- [regulation of macroautophagy](http://purl.obolibrary.org/obo/GO_0016241) [label](http://www.w3.org/2000/01/rdf-schema#label) "regulation of macroautophagy" -- [rhombomere 1 development](http://purl.obolibrary.org/obo/GO_0021567) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The process whose specific outcome is the progression of rhombomere 1 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." +- [regulation of macroautophagy](http://purl.obolibrary.org/obo/GO_0016241) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "regulation of starvation-induced autophagy" - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dph" - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:jid" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:ascb_2009" - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:curators" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:tb" + +- Class: [regulation of macroautophagy](http://purl.obolibrary.org/obo/GO_0016241) - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GO_REF:0000021" +- [regulation of macroautophagy](http://purl.obolibrary.org/obo/GO_0016241) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([regulates](http://purl.obolibrary.org/obo/RO_0002211) some [macroautophagy](http://purl.obolibrary.org/obo/GO_0016236)) - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dgh" +- [regulation of macroautophagy](http://purl.obolibrary.org/obo/GO_0016241) SubClassOf [regulation of autophagy](http://purl.obolibrary.org/obo/GO_0010506) - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:cls" +- [regulation of macroautophagy](http://purl.obolibrary.org/obo/GO_0016241) SubClassOf [regulates](http://purl.obolibrary.org/obo/RO_0002211) some [macroautophagy](http://purl.obolibrary.org/obo/GO_0016236) -- [rhombomere 1 development](http://purl.obolibrary.org/obo/GO_0021567) [label](http://www.w3.org/2000/01/rdf-schema#label) "rhombomere 1 development" -- [rhombomere 1 development](http://purl.obolibrary.org/obo/GO_0021567) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" -- Class: [rhombomere 1 development](http://purl.obolibrary.org/obo/GO_0021567) +### regulation of macromolecule biosynthetic process `http://purl.obolibrary.org/obo/GO_0010556` +#### Removed +- [regulation of macromolecule biosynthetic process](http://purl.obolibrary.org/obo/GO_0010556) SubClassOf [regulation of biosynthetic process](http://purl.obolibrary.org/obo/GO_0009889) -- [rhombomere 1 development](http://purl.obolibrary.org/obo/GO_0021567) EquivalentTo [anatomical structure development](http://purl.obolibrary.org/obo/GO_0048856) and ([results in development of](http://purl.obolibrary.org/obo/RO_0002296) some [rhombomere 1](http://purl.obolibrary.org/obo/UBERON_0005499)) +#### Added +- [regulation of macromolecule biosynthetic process](http://purl.obolibrary.org/obo/GO_0010556) SubClassOf [regulation of cellular biosynthetic process](http://purl.obolibrary.org/obo/GO_0031326) -- [rhombomere 1 development](http://purl.obolibrary.org/obo/GO_0021567) SubClassOf [results in development of](http://purl.obolibrary.org/obo/RO_0002296) some [rhombomere 1](http://purl.obolibrary.org/obo/UBERON_0005499) -- [rhombomere 1 development](http://purl.obolibrary.org/obo/GO_0021567) SubClassOf [rhombomere development](http://purl.obolibrary.org/obo/GO_0021546) +### regulation of neuron apoptotic process `http://purl.obolibrary.org/obo/GO_0043523` +#### Removed +- [regulation of neuron apoptotic process](http://purl.obolibrary.org/obo/GO_0043523) SubClassOf [regulation of neuron death](http://purl.obolibrary.org/obo/GO_1901214) -### rhombomere 1 formation `http://purl.obolibrary.org/obo/GO_0021652` -#### Added -- [rhombomere 1 formation](http://purl.obolibrary.org/obo/GO_0021652) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0021652" +### regulation of neuron death `http://purl.obolibrary.org/obo/GO_1901214` +#### Removed +- [regulation of neuron death](http://purl.obolibrary.org/obo/GO_1901214) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that modulates the frequency, rate or extent of neuron death." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" -- [rhombomere 1 formation](http://purl.obolibrary.org/obo/GO_0021652) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The process that gives rise to rhombomere 1. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dph" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:rph" - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:jid" +- [regulation of neuron death](http://purl.obolibrary.org/obo/GO_1901214) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:1901214" - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:curators" +- [regulation of neuron death](http://purl.obolibrary.org/obo/GO_1901214) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "regulation of neuron cell death" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GO_REF:0000021" +- [regulation of neuron death](http://purl.obolibrary.org/obo/GO_1901214) [label](http://www.w3.org/2000/01/rdf-schema#label) "regulation of neuron death" - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dgh" +- [regulation of neuron death](http://purl.obolibrary.org/obo/GO_1901214) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2012-08-02T09:57:41Z" - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:cls" +- [regulation of neuron death](http://purl.obolibrary.org/obo/GO_1901214) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "regulation of neuronal cell death" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" -- [rhombomere 1 formation](http://purl.obolibrary.org/obo/GO_0021652) [label](http://www.w3.org/2000/01/rdf-schema#label) "rhombomere 1 formation" +- [regulation of neuron death](http://purl.obolibrary.org/obo/GO_1901214) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "rph" -- [rhombomere 1 formation](http://purl.obolibrary.org/obo/GO_0021652) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" +- [regulation of neuron death](http://purl.obolibrary.org/obo/GO_1901214) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" -- Class: [rhombomere 1 formation](http://purl.obolibrary.org/obo/GO_0021652) +- Class: [regulation of neuron death](http://purl.obolibrary.org/obo/GO_1901214) -- [rhombomere 1 formation](http://purl.obolibrary.org/obo/GO_0021652) EquivalentTo [anatomical structure formation involved in morphogenesis](http://purl.obolibrary.org/obo/GO_0048646) and ([results in formation of](http://purl.obolibrary.org/obo/RO_0002297) some [rhombomere 1](http://purl.obolibrary.org/obo/UBERON_0005499)) +- [regulation of neuron death](http://purl.obolibrary.org/obo/GO_1901214) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([regulates](http://purl.obolibrary.org/obo/RO_0002211) some [neuron death](http://purl.obolibrary.org/obo/GO_0070997)) -- [rhombomere 1 formation](http://purl.obolibrary.org/obo/GO_0021652) SubClassOf [results in formation of](http://purl.obolibrary.org/obo/RO_0002297) some [rhombomere 1](http://purl.obolibrary.org/obo/UBERON_0005499) +- [regulation of neuron death](http://purl.obolibrary.org/obo/GO_1901214) SubClassOf [regulation of cellular process](http://purl.obolibrary.org/obo/GO_0050794) -- [rhombomere 1 formation](http://purl.obolibrary.org/obo/GO_0021652) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [rhombomere 1 morphogenesis](http://purl.obolibrary.org/obo/GO_0021651) +- [regulation of neuron death](http://purl.obolibrary.org/obo/GO_1901214) SubClassOf [regulates](http://purl.obolibrary.org/obo/RO_0002211) some [neuron death](http://purl.obolibrary.org/obo/GO_0070997) -- [rhombomere 1 formation](http://purl.obolibrary.org/obo/GO_0021652) SubClassOf [rhombomere formation](http://purl.obolibrary.org/obo/GO_0021594) +- [regulation of neuron death](http://purl.obolibrary.org/obo/GO_1901214) SubClassOf [in taxon](http://purl.obolibrary.org/obo/RO_0002162) only [Metazoa](http://purl.obolibrary.org/obo/NCBITaxon_33208) +- [regulation of neuron death](http://purl.obolibrary.org/obo/GO_1901214) SubClassOf [only in taxon](http://purl.obolibrary.org/obo/RO_0002160) some [Metazoa](http://purl.obolibrary.org/obo/NCBITaxon_33208) -### rhombomere 1 lateral wall `http://purl.obolibrary.org/obo/UBERON_0005567` -#### Added -- [rhombomere 1 lateral wall](http://purl.obolibrary.org/obo/UBERON_0005567) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "lateral wall rhombomere 1" - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ZFA:0000781" -- [rhombomere 1 lateral wall](http://purl.obolibrary.org/obo/UBERON_0005567) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "uberon" +### regulation of neurotransmitter uptake `http://purl.obolibrary.org/obo/GO_0051580` -- [rhombomere 1 lateral wall](http://purl.obolibrary.org/obo/UBERON_0005567) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A rhombomere lateral wall that is part of a rhombomere 1." - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "OBOL:automatic" +#### Added +- [regulation of neurotransmitter uptake](http://purl.obolibrary.org/obo/GO_0051580) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" -- [rhombomere 1 lateral wall](http://purl.obolibrary.org/obo/UBERON_0005567) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ZFA:0000781" +- [regulation of neurotransmitter uptake](http://purl.obolibrary.org/obo/GO_0051580) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0051580" -- [rhombomere 1 lateral wall](http://purl.obolibrary.org/obo/UBERON_0005567) [label](http://www.w3.org/2000/01/rdf-schema#label) "rhombomere 1 lateral wall" +- [regulation of neurotransmitter uptake](http://purl.obolibrary.org/obo/GO_0051580) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "regulation of neurotransmitter import" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dph" -- [rhombomere 1 lateral wall](http://purl.obolibrary.org/obo/UBERON_0005567) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "EHDAA2:0001641" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:tb" -- [rhombomere 1 lateral wall](http://purl.obolibrary.org/obo/UBERON_0005567) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [vertebrate_core](http://purl.obolibrary.org/obo/uberon/core#vertebrate_core) +- [regulation of neurotransmitter uptake](http://purl.obolibrary.org/obo/GO_0051580) [label](http://www.w3.org/2000/01/rdf-schema#label) "regulation of neurotransmitter uptake" -- [rhombomere 1 lateral wall](http://purl.obolibrary.org/obo/UBERON_0005567) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "TAO:0000781" +- [regulation of neurotransmitter uptake](http://purl.obolibrary.org/obo/GO_0051580) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [goslim_synapse](http://purl.obolibrary.org/obo/go#goslim_synapse) -- [rhombomere 1 lateral wall](http://purl.obolibrary.org/obo/UBERON_0005567) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "EMAPA:16482" +- [regulation of neurotransmitter uptake](http://purl.obolibrary.org/obo/GO_0051580) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that modulates the frequency, rate or extent of the directed movement of a neurotransmitter into a neuron or glial cell." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:ai" -- [rhombomere 1 lateral wall](http://purl.obolibrary.org/obo/UBERON_0005567) [id](http://www.geneontology.org/formats/oboInOwl#id) "UBERON:0005567" +- [regulation of neurotransmitter uptake](http://purl.obolibrary.org/obo/GO_0051580) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "regulation of neurotransmitter reuptake" -- Class: [rhombomere 1 lateral wall](http://purl.obolibrary.org/obo/UBERON_0005567) +- Class: [regulation of neurotransmitter uptake](http://purl.obolibrary.org/obo/GO_0051580) -- [rhombomere 1 lateral wall](http://purl.obolibrary.org/obo/UBERON_0005567) EquivalentTo [rhombomere lateral wall](http://purl.obolibrary.org/obo/UBERON_0005501) and ([part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [rhombomere 1](http://purl.obolibrary.org/obo/UBERON_0005499)) +- [regulation of neurotransmitter uptake](http://purl.obolibrary.org/obo/GO_0051580) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([regulates](http://purl.obolibrary.org/obo/RO_0002211) some [neurotransmitter uptake](http://purl.obolibrary.org/obo/GO_0001504)) -- [rhombomere 1 lateral wall](http://purl.obolibrary.org/obo/UBERON_0005567) SubClassOf [rhombomere lateral wall](http://purl.obolibrary.org/obo/UBERON_0005501) +- [regulation of neurotransmitter uptake](http://purl.obolibrary.org/obo/GO_0051580) SubClassOf [regulates](http://purl.obolibrary.org/obo/RO_0002211) some [neurotransmitter uptake](http://purl.obolibrary.org/obo/GO_0001504) -- [rhombomere 1 lateral wall](http://purl.obolibrary.org/obo/UBERON_0005567) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [rhombomere 1](http://purl.obolibrary.org/obo/UBERON_0005499) +- [regulation of neurotransmitter uptake](http://purl.obolibrary.org/obo/GO_0051580) SubClassOf [regulation of neurotransmitter transport](http://purl.obolibrary.org/obo/GO_0051588) -### rhombomere 1 morphogenesis `http://purl.obolibrary.org/obo/GO_0021651` +### regulation of nucleocytoplasmic transport `http://purl.obolibrary.org/obo/GO_0046822` #### Added -- [rhombomere 1 morphogenesis](http://purl.obolibrary.org/obo/GO_0021651) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" +- [regulation of nucleocytoplasmic transport](http://purl.obolibrary.org/obo/GO_0046822) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0046822" -- [rhombomere 1 morphogenesis](http://purl.obolibrary.org/obo/GO_0021651) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The process in which the anatomical structure of rhombomere 1 is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dph" +- [regulation of nucleocytoplasmic transport](http://purl.obolibrary.org/obo/GO_0046822) [label](http://www.w3.org/2000/01/rdf-schema#label) "regulation of nucleocytoplasmic transport" - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:jid" +- [regulation of nucleocytoplasmic transport](http://purl.obolibrary.org/obo/GO_0046822) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:curators" +- [regulation of nucleocytoplasmic transport](http://purl.obolibrary.org/obo/GO_0046822) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that modulates the frequency, rate or extent of the directed movement of substances between the nucleus and the cytoplasm." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:bf" + +- Class: [regulation of nucleocytoplasmic transport](http://purl.obolibrary.org/obo/GO_0046822) - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GO_REF:0000021" +- [regulation of nucleocytoplasmic transport](http://purl.obolibrary.org/obo/GO_0046822) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([regulates](http://purl.obolibrary.org/obo/RO_0002211) some [nucleocytoplasmic transport](http://purl.obolibrary.org/obo/GO_0006913)) - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dgh" +- [regulation of nucleocytoplasmic transport](http://purl.obolibrary.org/obo/GO_0046822) SubClassOf [regulation of intracellular transport](http://purl.obolibrary.org/obo/GO_0032386) - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:cls" +- [regulation of nucleocytoplasmic transport](http://purl.obolibrary.org/obo/GO_0046822) SubClassOf [regulates](http://purl.obolibrary.org/obo/RO_0002211) some [nucleocytoplasmic transport](http://purl.obolibrary.org/obo/GO_0006913) -- [rhombomere 1 morphogenesis](http://purl.obolibrary.org/obo/GO_0021651) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0021651" -- [rhombomere 1 morphogenesis](http://purl.obolibrary.org/obo/GO_0021651) [label](http://www.w3.org/2000/01/rdf-schema#label) "rhombomere 1 morphogenesis" +### regulation of platelet formation `http://purl.obolibrary.org/obo/GO_1905219` +#### Removed +- [regulation of platelet formation](http://purl.obolibrary.org/obo/GO_1905219) SubClassOf [regulation of cell morphogenesis involved in differentiation](http://purl.obolibrary.org/obo/GO_0010769) -- Class: [rhombomere 1 morphogenesis](http://purl.obolibrary.org/obo/GO_0021651) +#### Added +- [regulation of platelet formation](http://purl.obolibrary.org/obo/GO_1905219) SubClassOf [regulation of cell morphogenesis](http://purl.obolibrary.org/obo/GO_0022604) -- [rhombomere 1 morphogenesis](http://purl.obolibrary.org/obo/GO_0021651) EquivalentTo [anatomical structure morphogenesis](http://purl.obolibrary.org/obo/GO_0009653) and ([results in morphogenesis of](http://purl.obolibrary.org/obo/RO_0002298) some [rhombomere 1](http://purl.obolibrary.org/obo/UBERON_0005499)) -- [rhombomere 1 morphogenesis](http://purl.obolibrary.org/obo/GO_0021651) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [rhombomere 1 development](http://purl.obolibrary.org/obo/GO_0021567) +### regulation of protein export from nucleus `http://purl.obolibrary.org/obo/GO_0046825` -- [rhombomere 1 morphogenesis](http://purl.obolibrary.org/obo/GO_0021651) SubClassOf [results in morphogenesis of](http://purl.obolibrary.org/obo/RO_0002298) some [rhombomere 1](http://purl.obolibrary.org/obo/UBERON_0005499) +#### Added +- [regulation of protein export from nucleus](http://purl.obolibrary.org/obo/GO_0046825) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "regulation of protein-nucleus export" -- [rhombomere 1 morphogenesis](http://purl.obolibrary.org/obo/GO_0021651) SubClassOf [rhombomere morphogenesis](http://purl.obolibrary.org/obo/GO_0021593) +- [regulation of protein export from nucleus](http://purl.obolibrary.org/obo/GO_0046825) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that modulates the frequency, rate or extent of the directed movement of proteins from the nucleus to the cytoplasm." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:bf" +- [regulation of protein export from nucleus](http://purl.obolibrary.org/obo/GO_0046825) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "regulation of protein export out of nucleus" -### runt-related transcription factor 1 `http://purl.obolibrary.org/obo/PR_000014362` +- [regulation of protein export from nucleus](http://purl.obolibrary.org/obo/GO_0046825) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0046825" -#### Added -- [runt-related transcription factor 1](http://purl.obolibrary.org/obo/PR_000014362) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [runt-related transcription factor 1 (human)](http://purl.obolibrary.org/obo/PR_Q01196) +- [regulation of protein export from nucleus](http://purl.obolibrary.org/obo/GO_0046825) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "regulation of protein transport from nucleus to cytoplasm" +- [regulation of protein export from nucleus](http://purl.obolibrary.org/obo/GO_0046825) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" -### scalp `http://purl.obolibrary.org/obo/UBERON_0000403` -#### Removed -- [scalp](http://purl.obolibrary.org/obo/UBERON_0000403) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [regulation of protein export from nucleus](http://purl.obolibrary.org/obo/GO_0046825) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "regulation of protein export from cell nucleus" +- [regulation of protein export from nucleus](http://purl.obolibrary.org/obo/GO_0046825) [label](http://www.w3.org/2000/01/rdf-schema#label) "regulation of protein export from nucleus" +- Class: [regulation of protein export from nucleus](http://purl.obolibrary.org/obo/GO_0046825) -### scavenger receptor cysteine-rich type 1 protein M130 `http://purl.obolibrary.org/obo/PR_000001925` +- [regulation of protein export from nucleus](http://purl.obolibrary.org/obo/GO_0046825) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([regulates](http://purl.obolibrary.org/obo/RO_0002211) some [protein export from nucleus](http://purl.obolibrary.org/obo/GO_0006611)) -#### Added -- [scavenger receptor cysteine-rich type 1 protein M130](http://purl.obolibrary.org/obo/PR_000001925) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [scavenger receptor cysteine-rich type 1 protein M130 (human)](http://purl.obolibrary.org/obo/PR_Q86VB7) +- [regulation of protein export from nucleus](http://purl.obolibrary.org/obo/GO_0046825) SubClassOf [regulates](http://purl.obolibrary.org/obo/RO_0002211) some [protein export from nucleus](http://purl.obolibrary.org/obo/GO_0006611) +- [regulation of protein export from nucleus](http://purl.obolibrary.org/obo/GO_0046825) SubClassOf [regulation of nucleocytoplasmic transport](http://purl.obolibrary.org/obo/GO_0046822) -### sciatic nerve `http://purl.obolibrary.org/obo/UBERON_0001322` -#### Removed -- [sciatic nerve](http://purl.obolibrary.org/obo/UBERON_0001322) SubClassOf [neuron projection bundle](http://purl.obolibrary.org/obo/CARO_0001001) +- [regulation of protein export from nucleus](http://purl.obolibrary.org/obo/GO_0046825) SubClassOf [regulation of intracellular protein transport](http://purl.obolibrary.org/obo/GO_0033157) +### regulation of protein import into nucleus `http://purl.obolibrary.org/obo/GO_0042306` -### sclera `http://purl.obolibrary.org/obo/UBERON_0001773` -#### Removed -- [sclera](http://purl.obolibrary.org/obo/UBERON_0001773) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +#### Added +- [regulation of protein import into nucleus](http://purl.obolibrary.org/obo/GO_0042306) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0042306" +- [regulation of protein import into nucleus](http://purl.obolibrary.org/obo/GO_0042306) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "regulation of protein-nucleus import" +- [regulation of protein import into nucleus](http://purl.obolibrary.org/obo/GO_0042306) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" -### scleral cell `http://purl.obolibrary.org/obo/CL_0000347` -#### Removed -- [scleral cell](http://purl.obolibrary.org/obo/CL_0000347) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [regulation of protein import into nucleus](http://purl.obolibrary.org/obo/GO_0042306) [label](http://www.w3.org/2000/01/rdf-schema#label) "regulation of protein import into nucleus" +- [regulation of protein import into nucleus](http://purl.obolibrary.org/obo/GO_0042306) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "regulation of protein transport from cytoplasm to nucleus" +- [regulation of protein import into nucleus](http://purl.obolibrary.org/obo/GO_0042306) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that modulates the frequency, rate or extent of movement of proteins from the cytoplasm to the nucleus." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:jl" -### scleral mesenchyme `http://purl.obolibrary.org/obo/UBERON_0010299` -#### Removed -- [scleral mesenchyme](http://purl.obolibrary.org/obo/UBERON_0010299) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [regulation of protein import into nucleus](http://purl.obolibrary.org/obo/GO_0042306) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "regulation of protein import into cell nucleus" +- Class: [regulation of protein import into nucleus](http://purl.obolibrary.org/obo/GO_0042306) +- [regulation of protein import into nucleus](http://purl.obolibrary.org/obo/GO_0042306) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([regulates](http://purl.obolibrary.org/obo/RO_0002211) some [protein import into nucleus](http://purl.obolibrary.org/obo/GO_0006606)) -### secondary lens fiber `http://purl.obolibrary.org/obo/CL_0002225` -#### Removed -- [secondary lens fiber](http://purl.obolibrary.org/obo/CL_0002225) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [regulation of protein import into nucleus](http://purl.obolibrary.org/obo/GO_0042306) SubClassOf [regulates](http://purl.obolibrary.org/obo/RO_0002211) some [protein import into nucleus](http://purl.obolibrary.org/obo/GO_0006606) +- [regulation of protein import into nucleus](http://purl.obolibrary.org/obo/GO_0042306) SubClassOf [regulation of nucleocytoplasmic transport](http://purl.obolibrary.org/obo/GO_0046822) +- [regulation of protein import into nucleus](http://purl.obolibrary.org/obo/GO_0042306) SubClassOf [regulation of intracellular protein transport](http://purl.obolibrary.org/obo/GO_0033157) -### secondary motor neuron `http://purl.obolibrary.org/obo/CL_0000536` -#### Removed -- [secondary motor neuron](http://purl.obolibrary.org/obo/CL_0000536) [label](http://www.w3.org/2000/01/rdf-schema#label) "secondary motor neuron" +- [regulation of protein import into nucleus](http://purl.obolibrary.org/obo/GO_0042306) SubClassOf [regulation of protein localization to nucleus](http://purl.obolibrary.org/obo/GO_1900180) -- [secondary motor neuron](http://purl.obolibrary.org/obo/CL_0000536) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "FMA:83620" -#### Added -- [secondary motor neuron](http://purl.obolibrary.org/obo/CL_0000536) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A secondary neuron (sensu Teleostei) that has a motor function." - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:1842357" +### regulation of protein serine/threonine kinase activity `http://purl.obolibrary.org/obo/GO_0071900` +#### Removed +- [regulation of protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0071900) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that modulates the rate, frequency, or extent of protein serine/threonine kinase activity." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:mah" -- [secondary motor neuron](http://purl.obolibrary.org/obo/CL_0000536) [label](http://www.w3.org/2000/01/rdf-schema#label) "secondary motor neuron (sensu Teleostei)" +- [regulation of protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0071900) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [gocheck_do_not_annotate](http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate) +- [regulation of protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0071900) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "mah" -### secondary neuron `http://purl.obolibrary.org/obo/CL_0000535` -#### Removed -- [secondary neuron](http://purl.obolibrary.org/obo/CL_0000535) [label](http://www.w3.org/2000/01/rdf-schema#label) "secondary neuron" +- [regulation of protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0071900) [label](http://www.w3.org/2000/01/rdf-schema#label) "regulation of protein serine/threonine kinase activity" -#### Added -- [secondary neuron](http://purl.obolibrary.org/obo/CL_0000535) [label](http://www.w3.org/2000/01/rdf-schema#label) "secondary neuron (sensu Teleostei)" +- [regulation of protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0071900) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0071900" -- [secondary neuron](http://purl.obolibrary.org/obo/CL_0000535) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A neuron of teleosts that develops later than a primary neuron, typically during the larval stages." - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:1842357" +- [regulation of protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0071900) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1242/dev.108.1.121" +- [regulation of protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0071900) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2010-09-15T03:08:35Z" -- [secondary neuron](http://purl.obolibrary.org/obo/CL_0000535) SubClassOf [only in taxon](http://purl.obolibrary.org/obo/RO_0002160) some [Teleostei](http://purl.obolibrary.org/obo/NCBITaxon_32443) - - [term tracker item](http://purl.obolibrary.org/obo/IAO_0000233) "https://github.com/obophenotype/cell-ontology/pull/1950" +- Class: [regulation of protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0071900) +- [regulation of protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0071900) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([regulates](http://purl.obolibrary.org/obo/RO_0002211) some [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674)) -### secondary oocyte `http://purl.obolibrary.org/obo/CL_0000655` -#### Removed -- [secondary oocyte](http://purl.obolibrary.org/obo/CL_0000655) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [regulation of protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0071900) SubClassOf [regulation of protein kinase activity](http://purl.obolibrary.org/obo/GO_0045859) +- [regulation of protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0071900) SubClassOf [regulates](http://purl.obolibrary.org/obo/RO_0002211) some [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) -### segmental bronchus `http://purl.obolibrary.org/obo/UBERON_0002184` + +### regulation of release of sequestered calcium ion into cytosol `http://purl.obolibrary.org/obo/GO_0051279` #### Added -- [segmental bronchus](http://purl.obolibrary.org/obo/UBERON_0002184) SubClassOf [has part](http://purl.obolibrary.org/obo/BFO_0000051) some [cartilage of bronchus](http://purl.obolibrary.org/obo/UBERON_0001956) +- [regulation of release of sequestered calcium ion into cytosol](http://purl.obolibrary.org/obo/GO_0051279) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0051279" -- [segmental bronchus](http://purl.obolibrary.org/obo/UBERON_0002184) SubClassOf [has part](http://purl.obolibrary.org/obo/BFO_0000051) some [lung mesenchyme](http://purl.obolibrary.org/obo/UBERON_0004883) +- [regulation of release of sequestered calcium ion into cytosol](http://purl.obolibrary.org/obo/GO_0051279) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "regulation of calcium ion (Ca2+) mobilization" -- [segmental bronchus](http://purl.obolibrary.org/obo/UBERON_0002184) SubClassOf [has part](http://purl.obolibrary.org/obo/BFO_0000051) some [bronchus smooth muscle](http://purl.obolibrary.org/obo/UBERON_0004242) +- [regulation of release of sequestered calcium ion into cytosol](http://purl.obolibrary.org/obo/GO_0051279) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" -- [segmental bronchus](http://purl.obolibrary.org/obo/UBERON_0002184) SubClassOf [has part](http://purl.obolibrary.org/obo/BFO_0000051) some [bronchus submucosal gland](http://purl.obolibrary.org/obo/UBERON_8410043) +- [regulation of release of sequestered calcium ion into cytosol](http://purl.obolibrary.org/obo/GO_0051279) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "regulation of release of sequestered calcium ion (Ca2+)" +- [regulation of release of sequestered calcium ion into cytosol](http://purl.obolibrary.org/obo/GO_0051279) [label](http://www.w3.org/2000/01/rdf-schema#label) "regulation of release of sequestered calcium ion into cytosol" -### semen `http://purl.obolibrary.org/obo/UBERON_0001968` -#### Removed -- [semen](http://purl.obolibrary.org/obo/UBERON_0001968) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [regulation of release of sequestered calcium ion into cytosol](http://purl.obolibrary.org/obo/GO_0051279) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "regulation of release of stored calcium ion (Ca2+) into cytosol" +- [regulation of release of sequestered calcium ion into cytosol](http://purl.obolibrary.org/obo/GO_0051279) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that modulates the frequency, rate or extent of the release into the cytosolic compartment of calcium ions sequestered in the endoplasmic reticulum or mitochondria." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:tb" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:ai" -### semicircular canal `http://purl.obolibrary.org/obo/UBERON_0001840` -#### Removed -- [semicircular canal](http://purl.obolibrary.org/obo/UBERON_0001840) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [regulation of release of sequestered calcium ion into cytosol](http://purl.obolibrary.org/obo/GO_0051279) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "regulation of calcium mobilization" +- [regulation of release of sequestered calcium ion into cytosol](http://purl.obolibrary.org/obo/GO_0051279) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "regulation of release of stored calcium ion (Ca2+) into cytoplasm" +- [regulation of release of sequestered calcium ion into cytosol](http://purl.obolibrary.org/obo/GO_0051279) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "regulation of cytoplasmic release of stored calcium ion (Ca2+)" -### sensory neuron of dorsal root ganglion `http://purl.obolibrary.org/obo/CL_1001451` -#### Removed -- [sensory neuron of dorsal root ganglion](http://purl.obolibrary.org/obo/CL_1001451) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [regulation of release of sequestered calcium ion into cytosol](http://purl.obolibrary.org/obo/GO_0051279) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "regulation of release of stored calcium ion (Ca2+)" +- [regulation of release of sequestered calcium ion into cytosol](http://purl.obolibrary.org/obo/GO_0051279) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "regulation of cytoplasmic release of sequestered calcium ion (Ca2+)" +- Class: [regulation of release of sequestered calcium ion into cytosol](http://purl.obolibrary.org/obo/GO_0051279) -### sensory neuron of spinal nerve `http://purl.obolibrary.org/obo/CL_0009000` -#### Removed -- [sensory neuron of spinal nerve](http://purl.obolibrary.org/obo/CL_0009000) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [regulation of release of sequestered calcium ion into cytosol](http://purl.obolibrary.org/obo/GO_0051279) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([regulates](http://purl.obolibrary.org/obo/RO_0002211) some [release of sequestered calcium ion into cytosol](http://purl.obolibrary.org/obo/GO_0051209)) +- [regulation of release of sequestered calcium ion into cytosol](http://purl.obolibrary.org/obo/GO_0051279) SubClassOf [regulation of sequestering of calcium ion](http://purl.obolibrary.org/obo/GO_0051282) +- [regulation of release of sequestered calcium ion into cytosol](http://purl.obolibrary.org/obo/GO_0051279) SubClassOf [regulation of calcium ion transmembrane transport](http://purl.obolibrary.org/obo/GO_1903169) -### serous pericardium `http://purl.obolibrary.org/obo/UBERON_0002357` -#### Removed -- [serous pericardium](http://purl.obolibrary.org/obo/UBERON_0002357) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000) +- [regulation of release of sequestered calcium ion into cytosol](http://purl.obolibrary.org/obo/GO_0051279) SubClassOf [regulates](http://purl.obolibrary.org/obo/RO_0002211) some [release of sequestered calcium ion into cytosol](http://purl.obolibrary.org/obo/GO_0051209) +### regulation of retrograde dense core granule transport `http://purl.obolibrary.org/obo/GO_1901954` -### set of muscles of vertebral column `http://purl.obolibrary.org/obo/UBERON_0004468` -#### Removed -- [set of muscles of vertebral column](http://purl.obolibrary.org/obo/UBERON_0004468) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000) +#### Added +- [regulation of retrograde dense core granule transport](http://purl.obolibrary.org/obo/GO_1901954) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that modulates the frequency, rate or extent of retrograde dense core granule transport." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:23358451" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:kmv" -### shoulder `http://purl.obolibrary.org/obo/UBERON_0001467` -#### Removed -- [shoulder](http://purl.obolibrary.org/obo/UBERON_0001467) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [regulation of retrograde dense core granule transport](http://purl.obolibrary.org/obo/GO_1901954) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2013-02-19T13:36:43Z" +- [regulation of retrograde dense core granule transport](http://purl.obolibrary.org/obo/GO_1901954) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" +- [regulation of retrograde dense core granule transport](http://purl.obolibrary.org/obo/GO_1901954) [label](http://www.w3.org/2000/01/rdf-schema#label) "regulation of retrograde dense core granule transport" -### shoulder connective tissue `http://purl.obolibrary.org/obo/UBERON_0003579` -#### Removed -- [shoulder connective tissue](http://purl.obolibrary.org/obo/UBERON_0003579) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [regulation of retrograde dense core granule transport](http://purl.obolibrary.org/obo/GO_1901954) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "pr" +- [regulation of retrograde dense core granule transport](http://purl.obolibrary.org/obo/GO_1901954) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:1901954" +- Class: [regulation of retrograde dense core granule transport](http://purl.obolibrary.org/obo/GO_1901954) -### shoulder joint `http://purl.obolibrary.org/obo/UBERON_0016884` -#### Removed -- [shoulder joint](http://purl.obolibrary.org/obo/UBERON_0016884) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [regulation of retrograde dense core granule transport](http://purl.obolibrary.org/obo/GO_1901954) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([regulates](http://purl.obolibrary.org/obo/RO_0002211) some [retrograde neuronal dense core vesicle transport](http://purl.obolibrary.org/obo/GO_1990049)) +- [regulation of retrograde dense core granule transport](http://purl.obolibrary.org/obo/GO_1901954) SubClassOf [regulates](http://purl.obolibrary.org/obo/RO_0002211) some [retrograde neuronal dense core vesicle transport](http://purl.obolibrary.org/obo/GO_1990049) +- [regulation of retrograde dense core granule transport](http://purl.obolibrary.org/obo/GO_1901954) SubClassOf [regulation of retrograde axon cargo transport](http://purl.obolibrary.org/obo/GO_2001017) -### sialic acid-binding Ig-like lectin 5 `http://purl.obolibrary.org/obo/PR_000001927` +- [regulation of retrograde dense core granule transport](http://purl.obolibrary.org/obo/GO_1901954) SubClassOf [regulation of vesicle transport along microtubule](http://purl.obolibrary.org/obo/GO_1901608) -#### Added -- [sialic acid-binding Ig-like lectin 5](http://purl.obolibrary.org/obo/PR_000001927) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [sialic acid-binding Ig-like lectin 5 (human)](http://purl.obolibrary.org/obo/PR_O15389) +- [regulation of retrograde dense core granule transport](http://purl.obolibrary.org/obo/GO_1901954) SubClassOf [regulation of dense core granule transport](http://purl.obolibrary.org/obo/GO_1904809) -### sialic acid-binding Ig-like lectin 6 `http://purl.obolibrary.org/obo/PR_000001928` +### regulation of sequestering of calcium ion `http://purl.obolibrary.org/obo/GO_0051282` #### Added -- [sialic acid-binding Ig-like lectin 6](http://purl.obolibrary.org/obo/PR_000001928) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [sialic acid-binding Ig-like lectin 6 (human)](http://purl.obolibrary.org/obo/PR_O43699) +- [regulation of sequestering of calcium ion](http://purl.obolibrary.org/obo/GO_0051282) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "regulation of calcium ion (Ca2+) retention" +- [regulation of sequestering of calcium ion](http://purl.obolibrary.org/obo/GO_0051282) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "regulation of retention of calcium ion (Ca2+)" -### sialoadhesin `http://purl.obolibrary.org/obo/PR_000001931` +- [regulation of sequestering of calcium ion](http://purl.obolibrary.org/obo/GO_0051282) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" -#### Added -- [sialoadhesin](http://purl.obolibrary.org/obo/PR_000001931) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [sialoadhesin (human)](http://purl.obolibrary.org/obo/PR_Q9BZZ2) +- [regulation of sequestering of calcium ion](http://purl.obolibrary.org/obo/GO_0051282) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "regulation of storage of calcium ion (Ca2+)" +- [regulation of sequestering of calcium ion](http://purl.obolibrary.org/obo/GO_0051282) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0051282" -### sigmoid colon `http://purl.obolibrary.org/obo/UBERON_0001159` -#### Removed -- [sigmoid colon](http://purl.obolibrary.org/obo/UBERON_0001159) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [regulation of sequestering of calcium ion](http://purl.obolibrary.org/obo/GO_0051282) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "regulation of calcium ion (Ca2+) storage" +- [regulation of sequestering of calcium ion](http://purl.obolibrary.org/obo/GO_0051282) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "regulation of sequestration of calcium ion (Ca2+)" +- [regulation of sequestering of calcium ion](http://purl.obolibrary.org/obo/GO_0051282) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "regulation of calcium ion (Ca2+) sequestration" -### signal transducer CD24 `http://purl.obolibrary.org/obo/PR_000001932` +- [regulation of sequestering of calcium ion](http://purl.obolibrary.org/obo/GO_0051282) [label](http://www.w3.org/2000/01/rdf-schema#label) "regulation of sequestering of calcium ion" -#### Added -- [signal transducer CD24](http://purl.obolibrary.org/obo/PR_000001932) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [signal transducer CD24 (human)](http://purl.obolibrary.org/obo/PR_P25063) +- [regulation of sequestering of calcium ion](http://purl.obolibrary.org/obo/GO_0051282) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "regulation of sequestering of calcium ion (Ca2+)" +- [regulation of sequestering of calcium ion](http://purl.obolibrary.org/obo/GO_0051282) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that modulates the frequency, rate or extent of the binding or confining calcium ions such that they are separated from other components of a biological system." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:ai" -### simultaneous with `http://purl.obolibrary.org/obo/RO_0002082` +- [regulation of sequestering of calcium ion](http://purl.obolibrary.org/obo/GO_0051282) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "regulation of calcium ion (Ca2+) sequestering" -#### Added -- [simultaneous with](http://purl.obolibrary.org/obo/RO_0002082) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "x simultaneous with y iff ω(x) = ω(y) and ω(α ) = ω(α), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point and '=' indicates the same instance in time." +- Class: [regulation of sequestering of calcium ion](http://purl.obolibrary.org/obo/GO_0051282) -- Symmetric: [simultaneous with](http://purl.obolibrary.org/obo/RO_0002082) +- [regulation of sequestering of calcium ion](http://purl.obolibrary.org/obo/GO_0051282) EquivalentTo [biological regulation](http://purl.obolibrary.org/obo/GO_0065007) and ([regulates](http://purl.obolibrary.org/obo/RO_0002211) some [sequestering of calcium ion](http://purl.obolibrary.org/obo/GO_0051208)) +- [regulation of sequestering of calcium ion](http://purl.obolibrary.org/obo/GO_0051282) SubClassOf [regulates](http://purl.obolibrary.org/obo/RO_0002211) some [sequestering of calcium ion](http://purl.obolibrary.org/obo/GO_0051208) -### skeletal musculature `http://purl.obolibrary.org/obo/UBERON_0018254` -#### Removed -- [skeletal musculature](http://purl.obolibrary.org/obo/UBERON_0018254) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [regulation of sequestering of calcium ion](http://purl.obolibrary.org/obo/GO_0051282) SubClassOf [regulation of cellular process](http://purl.obolibrary.org/obo/GO_0050794) +- [regulation of sequestering of calcium ion](http://purl.obolibrary.org/obo/GO_0051282) SubClassOf [regulation of localization](http://purl.obolibrary.org/obo/GO_0032879) -### skeletal musculature of head `http://purl.obolibrary.org/obo/UBERON_0004461` +### regulation of translation `http://purl.obolibrary.org/obo/GO_0006417` #### Removed -- [skeletal musculature of head](http://purl.obolibrary.org/obo/UBERON_0004461) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000) +- [regulation of translation](http://purl.obolibrary.org/obo/GO_0006417) SubClassOf [regulation of macromolecule biosynthetic process](http://purl.obolibrary.org/obo/GO_0010556) -### skeletal tissue `http://purl.obolibrary.org/obo/UBERON_0004755` +### regulation of translational initiation `http://purl.obolibrary.org/obo/GO_0006446` #### Removed -- [skeletal tissue](http://purl.obolibrary.org/obo/UBERON_0004755) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [regulation of translational initiation](http://purl.obolibrary.org/obo/GO_0006446) SubClassOf [regulation of cellular metabolic process](http://purl.obolibrary.org/obo/GO_0031323) -### skeleton of `http://purl.obolibrary.org/obo/RO_0002576` -#### Removed -- [skeleton of](http://purl.obolibrary.org/obo/RO_0002576) Domain [connected anatomical structure](http://purl.obolibrary.org/obo/CARO_0000003) - -- [skeleton of](http://purl.obolibrary.org/obo/RO_0002576) Range [connected anatomical structure](http://purl.obolibrary.org/obo/CARO_0000003) +### release of sequestered calcium ion into cytosol `http://purl.obolibrary.org/obo/GO_0051209` #### Added -- [skeleton of](http://purl.obolibrary.org/obo/RO_0002576) Domain [anatomical structure](http://purl.obolibrary.org/obo/UBERON_0000061) +- [release of sequestered calcium ion into cytosol](http://purl.obolibrary.org/obo/GO_0051209) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "calcium ion (Ca2+) mobilization" -- [skeleton of](http://purl.obolibrary.org/obo/RO_0002576) Range [anatomical structure](http://purl.obolibrary.org/obo/UBERON_0000061) +- [release of sequestered calcium ion into cytosol](http://purl.obolibrary.org/obo/GO_0051209) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "release of sequestered calcium ion into cytoplasm" +- [release of sequestered calcium ion into cytosol](http://purl.obolibrary.org/obo/GO_0051209) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "release of stored calcium ion (Ca2+) into cytosol" -### skeleton of digitopodium `http://purl.obolibrary.org/obo/UBERON_0012150` -#### Removed -- [skeleton of digitopodium](http://purl.obolibrary.org/obo/UBERON_0012150) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000) +- [release of sequestered calcium ion into cytosol](http://purl.obolibrary.org/obo/GO_0051209) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "cytosolic release of stored calcium ion (Ca2+)" +- [release of sequestered calcium ion into cytosol](http://purl.obolibrary.org/obo/GO_0051209) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "release of stored calcium ion (Ca2+) into cytoplasm" +- [release of sequestered calcium ion into cytosol](http://purl.obolibrary.org/obo/GO_0051209) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" -### skeleton of lower jaw `http://purl.obolibrary.org/obo/UBERON_0003278` -#### Removed -- [skeleton of lower jaw](http://purl.obolibrary.org/obo/UBERON_0003278) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000) +- [release of sequestered calcium ion into cytosol](http://purl.obolibrary.org/obo/GO_0051209) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0051209" +- [release of sequestered calcium ion into cytosol](http://purl.obolibrary.org/obo/GO_0051209) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "calcium mobilization" +- [release of sequestered calcium ion into cytosol](http://purl.obolibrary.org/obo/GO_0051209) [label](http://www.w3.org/2000/01/rdf-schema#label) "release of sequestered calcium ion into cytosol" -### skeleton of pectoral complex `http://purl.obolibrary.org/obo/UBERON_0012475` -#### Removed -- [skeleton of pectoral complex](http://purl.obolibrary.org/obo/UBERON_0012475) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000) +- [release of sequestered calcium ion into cytosol](http://purl.obolibrary.org/obo/GO_0051209) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The process in which calcium ions sequestered in the endoplasmic reticulum, Golgi apparatus or mitochondria are released into the cytosolic compartment." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dph" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:1814929" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:mtg_lung" -### skeleton of pelvic complex `http://purl.obolibrary.org/obo/UBERON_0012476` -#### Removed -- [skeleton of pelvic complex](http://purl.obolibrary.org/obo/UBERON_0012476) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000) + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:hjd" +- [release of sequestered calcium ion into cytosol](http://purl.obolibrary.org/obo/GO_0051209) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "cytoplasmic release of sequestered calcium ion (Ca2+)" +- [release of sequestered calcium ion into cytosol](http://purl.obolibrary.org/obo/GO_0051209) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "cytosolic release of sequestered calcium ion (Ca2+)" -### skeleton of upper jaw `http://purl.obolibrary.org/obo/UBERON_0003277` -#### Removed -- [skeleton of upper jaw](http://purl.obolibrary.org/obo/UBERON_0003277) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000) +- [release of sequestered calcium ion into cytosol](http://purl.obolibrary.org/obo/GO_0051209) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "cytoplasmic release of stored calcium ion (Ca2+)" +- [release of sequestered calcium ion into cytosol](http://purl.obolibrary.org/obo/GO_0051209) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "release of sequestered calcium ion (Ca2+)" +- [release of sequestered calcium ion into cytosol](http://purl.obolibrary.org/obo/GO_0051209) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "release of stored calcium ion (Ca2+)" -### skin appendage follicle `http://purl.obolibrary.org/obo/UBERON_0036150` -#### Removed -- [skin appendage follicle](http://purl.obolibrary.org/obo/UBERON_0036150) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- Class: [release of sequestered calcium ion into cytosol](http://purl.obolibrary.org/obo/GO_0051209) +- [release of sequestered calcium ion into cytosol](http://purl.obolibrary.org/obo/GO_0051209) EquivalentTo [transport](http://purl.obolibrary.org/obo/GO_0006810) and ([has target start location](http://purl.obolibrary.org/obo/RO_0002338) some [intracellular membrane-bounded organelle](http://purl.obolibrary.org/obo/GO_0043231)) and ([has target end location](http://purl.obolibrary.org/obo/RO_0002339) some [cytosol](http://purl.obolibrary.org/obo/GO_0005829)) and ([results in transport across](http://purl.obolibrary.org/obo/RO_0002342) some [membrane](http://purl.obolibrary.org/obo/GO_0016020)) and ([has primary input](http://purl.obolibrary.org/obo/RO_0004009) some [CHEBI_29108](http://purl.obolibrary.org/obo/CHEBI_29108)) +- [release of sequestered calcium ion into cytosol](http://purl.obolibrary.org/obo/GO_0051209) SubClassOf [calcium ion transmembrane import into cytosol](http://purl.obolibrary.org/obo/GO_0097553) -### skin bony tubercle `http://purl.obolibrary.org/obo/UBERON_0017163` -#### Removed -- [skin bony tubercle](http://purl.obolibrary.org/obo/UBERON_0017163) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [release of sequestered calcium ion into cytosol](http://purl.obolibrary.org/obo/GO_0051209) SubClassOf [negative regulation of sequestering of calcium ion](http://purl.obolibrary.org/obo/GO_0051283) +- [release of sequestered calcium ion into cytosol](http://purl.obolibrary.org/obo/GO_0051209) SubClassOf [has target start location](http://purl.obolibrary.org/obo/RO_0002338) some [intracellular membrane-bounded organelle](http://purl.obolibrary.org/obo/GO_0043231) -### smooth muscle cell derived foam cell `http://purl.obolibrary.org/obo/CL_0000892` -#### Removed -- [smooth muscle cell derived foam cell](http://purl.obolibrary.org/obo/CL_0000892) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +### release of sequestered calcium ion into cytosol by Golgi `http://purl.obolibrary.org/obo/GO_0061454` +#### Added +- [release of sequestered calcium ion into cytosol by Golgi](http://purl.obolibrary.org/obo/GO_0061454) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0061454" +- [release of sequestered calcium ion into cytosol by Golgi](http://purl.obolibrary.org/obo/GO_0061454) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "dph" -### sncg GABAergic cortical interneuron `http://purl.obolibrary.org/obo/CL_4023015` +- [release of sequestered calcium ion into cytosol by Golgi](http://purl.obolibrary.org/obo/GO_0061454) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" -#### Added -- [sncg GABAergic cortical interneuron](http://purl.obolibrary.org/obo/CL_4023015) [symbol](http://purl.obolibrary.org/obo/IAO_0000028) "sncg cortical interneuron" +- [release of sequestered calcium ion into cytosol by Golgi](http://purl.obolibrary.org/obo/GO_0061454) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2012-07-27T02:29:43Z" +- [release of sequestered calcium ion into cytosol by Golgi](http://purl.obolibrary.org/obo/GO_0061454) [label](http://www.w3.org/2000/01/rdf-schema#label) "release of sequestered calcium ion into cytosol by Golgi" -### somatostatin `http://purl.obolibrary.org/obo/PR_000015665` +- [release of sequestered calcium ion into cytosol by Golgi](http://purl.obolibrary.org/obo/GO_0061454) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "Golgi calcium ion export" -#### Added -- [somatostatin](http://purl.obolibrary.org/obo/PR_000015665) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [somatostatin (human)](http://purl.obolibrary.org/obo/PR_P61278) +- [release of sequestered calcium ion into cytosol by Golgi](http://purl.obolibrary.org/obo/GO_0061454) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The directed movement of calcium ions (Ca2+) out of the Golgi apparatus into the cytosol." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dph" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:tb" -### somite `http://purl.obolibrary.org/obo/UBERON_0002329` -#### Removed -- [somite](http://purl.obolibrary.org/obo/UBERON_0002329) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- Class: [release of sequestered calcium ion into cytosol by Golgi](http://purl.obolibrary.org/obo/GO_0061454) +- [release of sequestered calcium ion into cytosol by Golgi](http://purl.obolibrary.org/obo/GO_0061454) EquivalentTo [transport](http://purl.obolibrary.org/obo/GO_0006810) and ([has target start location](http://purl.obolibrary.org/obo/RO_0002338) some [Golgi apparatus](http://purl.obolibrary.org/obo/GO_0005794)) and ([has target end location](http://purl.obolibrary.org/obo/RO_0002339) some [cytosol](http://purl.obolibrary.org/obo/GO_0005829)) and ([results in transport across](http://purl.obolibrary.org/obo/RO_0002342) some [membrane](http://purl.obolibrary.org/obo/GO_0016020)) and ([has primary input](http://purl.obolibrary.org/obo/RO_0004009) some [CHEBI_29108](http://purl.obolibrary.org/obo/CHEBI_29108)) +- [release of sequestered calcium ion into cytosol by Golgi](http://purl.obolibrary.org/obo/GO_0061454) SubClassOf [release of sequestered calcium ion into cytosol](http://purl.obolibrary.org/obo/GO_0051209) -### sonic hedgehog protein `http://purl.obolibrary.org/obo/PR_000014841` +- [release of sequestered calcium ion into cytosol by Golgi](http://purl.obolibrary.org/obo/GO_0061454) SubClassOf [has target start location](http://purl.obolibrary.org/obo/RO_0002338) some [Golgi apparatus](http://purl.obolibrary.org/obo/GO_0005794) -#### Added -- [sonic hedgehog protein](http://purl.obolibrary.org/obo/PR_000014841) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [sonic hedgehog protein (human)](http://purl.obolibrary.org/obo/PR_Q15465) +- [release of sequestered calcium ion into cytosol by Golgi](http://purl.obolibrary.org/obo/GO_0061454) SubClassOf [Golgi calcium ion transmembrane transport](http://purl.obolibrary.org/obo/GO_0061856) -### specifically dependent continuant `http://purl.obolibrary.org/obo/BFO_0000020` -#### Removed -- [specifically dependent continuant](http://purl.obolibrary.org/obo/BFO_0000020) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A continuant that inheres in or is borne by other entities. Every instance of A requires some specific instance of B which must always be the same."@en +### release of sequestered calcium ion into postsynaptic cytosol `http://purl.obolibrary.org/obo/GO_0099586` #### Added -- [specifically dependent continuant](http://purl.obolibrary.org/obo/BFO_0000020) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "A continuant that inheres in or is borne by other entities. Every instance of A requires some specific instance of B which must always be the same."@en +- [release of sequestered calcium ion into postsynaptic cytosol](http://purl.obolibrary.org/obo/GO_0099586) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The process in which calcium ions sequestered in the endoplasmic reticulum, Golgi apparatus or mitochondria are released into the postsynaptic cytosol." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dos" -- [specifically dependent continuant](http://purl.obolibrary.org/obo/BFO_0000020) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "b is a specifically dependent continuant = Def. b is a continuant & there is some independent continuant c which is not a spatial region and which is such that b s-depends_on c at every time t during the course of b’s existence. (axiom label in BFO2 Reference: [050-003])"@en +- [release of sequestered calcium ion into postsynaptic cytosol](http://purl.obolibrary.org/obo/GO_0099586) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" +- [release of sequestered calcium ion into postsynaptic cytosol](http://purl.obolibrary.org/obo/GO_0099586) [label](http://www.w3.org/2000/01/rdf-schema#label) "release of sequestered calcium ion into postsynaptic cytosol" -### sperm `http://purl.obolibrary.org/obo/CL_0000019` -#### Removed -- [sperm](http://purl.obolibrary.org/obo/CL_0000019) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [release of sequestered calcium ion into postsynaptic cytosol](http://purl.obolibrary.org/obo/GO_0099586) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [goslim_synapse](http://purl.obolibrary.org/obo/go#goslim_synapse) +- [release of sequestered calcium ion into postsynaptic cytosol](http://purl.obolibrary.org/obo/GO_0099586) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0099586" +- Class: [release of sequestered calcium ion into postsynaptic cytosol](http://purl.obolibrary.org/obo/GO_0099586) -### spermatid `http://purl.obolibrary.org/obo/CL_0000018` -#### Removed -- [spermatid](http://purl.obolibrary.org/obo/CL_0000018) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [release of sequestered calcium ion into postsynaptic cytosol](http://purl.obolibrary.org/obo/GO_0099586) EquivalentTo [transport](http://purl.obolibrary.org/obo/GO_0006810) and ([has target start location](http://purl.obolibrary.org/obo/RO_0002338) some [intracellular membrane-bounded organelle](http://purl.obolibrary.org/obo/GO_0043231)) and ([has target end location](http://purl.obolibrary.org/obo/RO_0002339) some [postsynaptic cytosol](http://purl.obolibrary.org/obo/GO_0099524)) and ([results in transport across](http://purl.obolibrary.org/obo/RO_0002342) some [organelle membrane](http://purl.obolibrary.org/obo/GO_0031090)) and ([has primary input](http://purl.obolibrary.org/obo/RO_0004009) some [CHEBI_29108](http://purl.obolibrary.org/obo/CHEBI_29108)) +- [release of sequestered calcium ion into postsynaptic cytosol](http://purl.obolibrary.org/obo/GO_0099586) SubClassOf [establishment of localization in cell](http://purl.obolibrary.org/obo/GO_0051649) +- [release of sequestered calcium ion into postsynaptic cytosol](http://purl.obolibrary.org/obo/GO_0099586) SubClassOf [has target end location](http://purl.obolibrary.org/obo/RO_0002339) some [postsynaptic cytosol](http://purl.obolibrary.org/obo/GO_0099524) -### spermatocyte `http://purl.obolibrary.org/obo/CL_0000017` -#### Removed -- [spermatocyte](http://purl.obolibrary.org/obo/CL_0000017) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [release of sequestered calcium ion into postsynaptic cytosol](http://purl.obolibrary.org/obo/GO_0099586) SubClassOf [occurs in](http://purl.obolibrary.org/obo/BFO_0000066) some [postsynapse](http://purl.obolibrary.org/obo/GO_0098794) +- [release of sequestered calcium ion into postsynaptic cytosol](http://purl.obolibrary.org/obo/GO_0099586) SubClassOf [release of sequestered calcium ion into cytosol](http://purl.obolibrary.org/obo/GO_0051209) +- [release of sequestered calcium ion into postsynaptic cytosol](http://purl.obolibrary.org/obo/GO_0099586) SubClassOf [results in transport across](http://purl.obolibrary.org/obo/RO_0002342) some [organelle membrane](http://purl.obolibrary.org/obo/GO_0031090) -### spinal cord interneuron `http://purl.obolibrary.org/obo/CL_0005000` -#### Removed -- [spinal cord interneuron](http://purl.obolibrary.org/obo/CL_0005000) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +### release of sequestered calcium ion into presynaptic cytosol `http://purl.obolibrary.org/obo/GO_0099585` +#### Added +- [release of sequestered calcium ion into presynaptic cytosol](http://purl.obolibrary.org/obo/GO_0099585) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" -### spinal cord medial motor column neuron `http://purl.obolibrary.org/obo/CL_2000024` -#### Removed -- [spinal cord medial motor column neuron](http://purl.obolibrary.org/obo/CL_2000024) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [release of sequestered calcium ion into presynaptic cytosol](http://purl.obolibrary.org/obo/GO_0099585) [label](http://www.w3.org/2000/01/rdf-schema#label) "release of sequestered calcium ion into presynaptic cytosol" +- [release of sequestered calcium ion into presynaptic cytosol](http://purl.obolibrary.org/obo/GO_0099585) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The process in which calcium ions sequestered in the endoplasmic reticulum, Golgi apparatus or mitochondria are released into the presynaptic cytosol." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dos" +- [release of sequestered calcium ion into presynaptic cytosol](http://purl.obolibrary.org/obo/GO_0099585) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [goslim_synapse](http://purl.obolibrary.org/obo/go#goslim_synapse) -### spinal cord motor neuron `http://purl.obolibrary.org/obo/CL_0011001` -#### Removed -- [spinal cord motor neuron](http://purl.obolibrary.org/obo/CL_0011001) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [release of sequestered calcium ion into presynaptic cytosol](http://purl.obolibrary.org/obo/GO_0099585) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0099585" +- Class: [release of sequestered calcium ion into presynaptic cytosol](http://purl.obolibrary.org/obo/GO_0099585) +- [release of sequestered calcium ion into presynaptic cytosol](http://purl.obolibrary.org/obo/GO_0099585) EquivalentTo [transport](http://purl.obolibrary.org/obo/GO_0006810) and ([has target start location](http://purl.obolibrary.org/obo/RO_0002338) some [intracellular membrane-bounded organelle](http://purl.obolibrary.org/obo/GO_0043231)) and ([has target end location](http://purl.obolibrary.org/obo/RO_0002339) some [presynaptic cytosol](http://purl.obolibrary.org/obo/GO_0099523)) and ([results in transport across](http://purl.obolibrary.org/obo/RO_0002342) some [organelle membrane](http://purl.obolibrary.org/obo/GO_0031090)) and ([has primary input](http://purl.obolibrary.org/obo/RO_0004009) some [CHEBI_29108](http://purl.obolibrary.org/obo/CHEBI_29108)) -### spiral ganglion neuron `http://purl.obolibrary.org/obo/CL_0011113` -#### Removed -- [spiral ganglion neuron](http://purl.obolibrary.org/obo/CL_0011113) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [release of sequestered calcium ion into presynaptic cytosol](http://purl.obolibrary.org/obo/GO_0099585) SubClassOf [results in transport across](http://purl.obolibrary.org/obo/RO_0002342) some [organelle membrane](http://purl.obolibrary.org/obo/GO_0031090) +- [release of sequestered calcium ion into presynaptic cytosol](http://purl.obolibrary.org/obo/GO_0099585) SubClassOf [release of sequestered calcium ion into cytosol](http://purl.obolibrary.org/obo/GO_0051209) +- [release of sequestered calcium ion into presynaptic cytosol](http://purl.obolibrary.org/obo/GO_0099585) SubClassOf [establishment of localization in cell](http://purl.obolibrary.org/obo/GO_0051649) -### splanchnic nerve `http://purl.obolibrary.org/obo/UBERON_0003715` -#### Removed -- [splanchnic nerve](http://purl.obolibrary.org/obo/UBERON_0003715) SubClassOf [neuron projection bundle](http://purl.obolibrary.org/obo/CARO_0001001) +- [release of sequestered calcium ion into presynaptic cytosol](http://purl.obolibrary.org/obo/GO_0099585) SubClassOf [has target end location](http://purl.obolibrary.org/obo/RO_0002339) some [presynaptic cytosol](http://purl.obolibrary.org/obo/GO_0099523) +- [release of sequestered calcium ion into presynaptic cytosol](http://purl.obolibrary.org/obo/GO_0099585) SubClassOf [occurs in](http://purl.obolibrary.org/obo/BFO_0000066) some [presynapse](http://purl.obolibrary.org/obo/GO_0098793) -### splanchnocranium `http://purl.obolibrary.org/obo/UBERON_0008895` +### requires discussion `http://purl.obolibrary.org/obo/IAO_0000428` #### Removed -- [splanchnocranium](http://purl.obolibrary.org/obo/UBERON_0008895) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) - +- [requires discussion](http://purl.obolibrary.org/obo/IAO_0000428) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A term that is metadata complete, has been reviewed, and problems have been identified that require discussion before release. Such a term requires editor note(s) to identify the outstanding issues."@en +- [requires discussion](http://purl.obolibrary.org/obo/IAO_0000428) [IAO_0000119](http://purl.obolibrary.org/obo/IAO_0000119) "group:OBI"@en -### spleen primordium `http://purl.obolibrary.org/obo/UBERON_0006293` -#### Removed -- [spleen primordium](http://purl.obolibrary.org/obo/UBERON_0006293) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [requires discussion](http://purl.obolibrary.org/obo/IAO_0000428) [label](http://www.w3.org/2000/01/rdf-schema#label) "requires discussion"@en +- [requires discussion](http://purl.obolibrary.org/obo/IAO_0000428) [IAO_0000117](http://purl.obolibrary.org/obo/IAO_0000117) "Alan Ruttenberg"@en +- [requires discussion](http://purl.obolibrary.org/obo/IAO_0000428) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "requires discussion"@en -### splenic marginal zone macrophage `http://purl.obolibrary.org/obo/CL_0000872` -#### Removed -- [splenic marginal zone macrophage](http://purl.obolibrary.org/obo/CL_0000872) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- Individual: [requires discussion](http://purl.obolibrary.org/obo/IAO_0000428) -### splenic metallophillic macrophage `http://purl.obolibrary.org/obo/CL_0000873` -#### Removed -- [splenic metallophillic macrophage](http://purl.obolibrary.org/obo/CL_0000873) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +### response to decreased oxygen levels `http://purl.obolibrary.org/obo/GO_0036293` +#### Added +- [response to decreased oxygen levels](http://purl.obolibrary.org/obo/GO_0036293) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting a decline in the level of oxygen." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:al" +- [response to decreased oxygen levels](http://purl.obolibrary.org/obo/GO_0036293) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "This term should be used when a decrease in oxygen levels is not considered a stress response. For a hypoxic stress response, consider instead 'response to hypoxia ; GO:0001666'." -### splenic red pulp macrophage `http://purl.obolibrary.org/obo/CL_0000874` -#### Removed -- [splenic red pulp macrophage](http://purl.obolibrary.org/obo/CL_0000874) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [response to decreased oxygen levels](http://purl.obolibrary.org/obo/GO_0036293) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" +- [response to decreased oxygen levels](http://purl.obolibrary.org/obo/GO_0036293) [label](http://www.w3.org/2000/01/rdf-schema#label) "response to decreased oxygen levels" +- [response to decreased oxygen levels](http://purl.obolibrary.org/obo/GO_0036293) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "bf" -### splenic white pulp macrophage `http://purl.obolibrary.org/obo/CL_0000876` -#### Removed -- [splenic white pulp macrophage](http://purl.obolibrary.org/obo/CL_0000876) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [response to decreased oxygen levels](http://purl.obolibrary.org/obo/GO_0036293) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "response to lowered oxygen levels" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:bf" +- [response to decreased oxygen levels](http://purl.obolibrary.org/obo/GO_0036293) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2012-07-20T01:05:46Z" +- [response to decreased oxygen levels](http://purl.obolibrary.org/obo/GO_0036293) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0036293" -### spongiotrophoblast layer `http://purl.obolibrary.org/obo/UBERON_0004021` -#### Removed -- [spongiotrophoblast layer](http://purl.obolibrary.org/obo/UBERON_0004021) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- Class: [response to decreased oxygen levels](http://purl.obolibrary.org/obo/GO_0036293) +- [response to decreased oxygen levels](http://purl.obolibrary.org/obo/GO_0036293) SubClassOf [response to oxygen levels](http://purl.obolibrary.org/obo/GO_0070482) -### sst GABAergic cortical interneuron `http://purl.obolibrary.org/obo/CL_4023017` +### response to hypoxia `http://purl.obolibrary.org/obo/GO_0001666` #### Added -- [sst GABAergic cortical interneuron](http://purl.obolibrary.org/obo/CL_4023017) [symbol](http://purl.obolibrary.org/obo/IAO_0000028) "sst cortical interneuron" +- [response to hypoxia](http://purl.obolibrary.org/obo/GO_0001666) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "response to hypoxic stress" +- [response to hypoxia](http://purl.obolibrary.org/obo/GO_0001666) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "response to sustained hypoxia" -### sst chodl GABAergic cortical interneuron `http://purl.obolibrary.org/obo/CL_4023121` +- [response to hypoxia](http://purl.obolibrary.org/obo/GO_0001666) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:hjd" -#### Added -- [sst chodl GABAergic cortical interneuron](http://purl.obolibrary.org/obo/CL_4023121) [symbol](http://purl.obolibrary.org/obo/IAO_0000028) "sst chodl cortical interneuron" +- [response to hypoxia](http://purl.obolibrary.org/obo/GO_0001666) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "response to intermittent hypoxia" +- [response to hypoxia](http://purl.obolibrary.org/obo/GO_0001666) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "response to lowered oxygen tension" -### stellate L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (Mmus) `http://purl.obolibrary.org/obo/CL_4023080` +- [response to hypoxia](http://purl.obolibrary.org/obo/GO_0001666) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" -#### Added -- [stellate L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (Mmus)](http://purl.obolibrary.org/obo/CL_4023080) [symbol](http://purl.obolibrary.org/obo/IAO_0000028) "stellate L6 IT glut MOp" +- [response to hypoxia](http://purl.obolibrary.org/obo/GO_0001666) [label](http://www.w3.org/2000/01/rdf-schema#label) "response to hypoxia" +- [response to hypoxia](http://purl.obolibrary.org/obo/GO_0001666) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0001666" -### stomach primordium `http://purl.obolibrary.org/obo/UBERON_0012172` -#### Removed -- [stomach primordium](http://purl.obolibrary.org/obo/UBERON_0012172) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [response to hypoxia](http://purl.obolibrary.org/obo/GO_0001666) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "Note that this term should not be confused with 'response to anoxia ; GO:0034059'. Note that in laboratory studies, hypoxia is typically studied at O2 concentrations ranging from 0.1 - 5%." +- Class: [response to hypoxia](http://purl.obolibrary.org/obo/GO_0001666) +- [response to hypoxia](http://purl.obolibrary.org/obo/GO_0001666) SubClassOf [response to stress](http://purl.obolibrary.org/obo/GO_0006950) -### stratified epithelial cell `http://purl.obolibrary.org/obo/CL_0000079` -#### Removed -- [stratified epithelial cell](http://purl.obolibrary.org/obo/CL_0000079) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [response to hypoxia](http://purl.obolibrary.org/obo/GO_0001666) SubClassOf [response to decreased oxygen levels](http://purl.obolibrary.org/obo/GO_0036293) +### response to oxygen levels `http://purl.obolibrary.org/obo/GO_0070482` -### stratum basale of epidermis `http://purl.obolibrary.org/obo/UBERON_0002025` -#### Removed -- [stratum basale of epidermis](http://purl.obolibrary.org/obo/UBERON_0002025) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +#### Added +- [response to oxygen levels](http://purl.obolibrary.org/obo/GO_0070482) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:mah" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:BHF" +- [response to oxygen levels](http://purl.obolibrary.org/obo/GO_0070482) [label](http://www.w3.org/2000/01/rdf-schema#label) "response to oxygen levels" -### stratum granulosum of epidermis `http://purl.obolibrary.org/obo/UBERON_0002069` -#### Removed -- [stratum granulosum of epidermis](http://purl.obolibrary.org/obo/UBERON_0002069) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [response to oxygen levels](http://purl.obolibrary.org/obo/GO_0070482) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0070482" + +- [response to oxygen levels](http://purl.obolibrary.org/obo/GO_0070482) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" + +- Class: [response to oxygen levels](http://purl.obolibrary.org/obo/GO_0070482) +- [response to oxygen levels](http://purl.obolibrary.org/obo/GO_0070482) SubClassOf [response to abiotic stimulus](http://purl.obolibrary.org/obo/GO_0009628) -### stratum spinosum of epidermis `http://purl.obolibrary.org/obo/UBERON_0002026` +### retinal ganglion cell A1 `http://purl.obolibrary.org/obo/CL_0004120` #### Removed -- [stratum spinosum of epidermis](http://purl.obolibrary.org/obo/UBERON_0002026) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [retinal ganglion cell A1](http://purl.obolibrary.org/obo/CL_0004120) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "I-2" +#### Added +- [retinal ganglion cell A1](http://purl.obolibrary.org/obo/CL_0004120) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "I-2" -### stroma of bone marrow `http://purl.obolibrary.org/obo/UBERON_0007195` +### retinal ganglion cell A2 `http://purl.obolibrary.org/obo/CL_0004138` #### Removed -- [stroma of bone marrow](http://purl.obolibrary.org/obo/UBERON_0007195) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [retinal ganglion cell A2](http://purl.obolibrary.org/obo/CL_0004138) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "type I" +- [retinal ganglion cell A2](http://purl.obolibrary.org/obo/CL_0004138) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "I-1" +#### Added +- [retinal ganglion cell A2](http://purl.obolibrary.org/obo/CL_0004138) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "type I" -### stromal cell `http://purl.obolibrary.org/obo/CL_0000499` -#### Removed -- [stromal cell](http://purl.obolibrary.org/obo/CL_0000499) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [retinal ganglion cell A2](http://purl.obolibrary.org/obo/CL_0004138) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "I-1" +### retrograde neuronal dense core vesicle transport `http://purl.obolibrary.org/obo/GO_1990049` -### structure with developmental contribution from neural crest `http://purl.obolibrary.org/obo/UBERON_0010314` -#### Removed -- [structure with developmental contribution from neural crest](http://purl.obolibrary.org/obo/UBERON_0010314) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +#### Added +- [retrograde neuronal dense core vesicle transport](http://purl.obolibrary.org/obo/GO_1990049) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The directed movement of neuronal dense core vesicles along axonal microtubules towards the cell body." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:23358451" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:24762653" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:kmv" -### stylopod `http://purl.obolibrary.org/obo/UBERON_0002472` -#### Removed -- [stylopod](http://purl.obolibrary.org/obo/UBERON_0002472) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000) +- [retrograde neuronal dense core vesicle transport](http://purl.obolibrary.org/obo/GO_1990049) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:1990049" +- [retrograde neuronal dense core vesicle transport](http://purl.obolibrary.org/obo/GO_1990049) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "retrograde dense core granule trafficking" +- [retrograde neuronal dense core vesicle transport](http://purl.obolibrary.org/obo/GO_1990049) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "retrograde dense core granule transport" -### stylopodial skeleton `http://purl.obolibrary.org/obo/UBERON_0011583` -#### Removed -- [stylopodial skeleton](http://purl.obolibrary.org/obo/UBERON_0011583) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000) +- [retrograde neuronal dense core vesicle transport](http://purl.obolibrary.org/obo/GO_1990049) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" +- [retrograde neuronal dense core vesicle transport](http://purl.obolibrary.org/obo/GO_1990049) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "pr" +- [retrograde neuronal dense core vesicle transport](http://purl.obolibrary.org/obo/GO_1990049) [label](http://www.w3.org/2000/01/rdf-schema#label) "retrograde neuronal dense core vesicle transport" -### subserosa `http://purl.obolibrary.org/obo/UBERON_0012375` -#### Removed -- [subserosa](http://purl.obolibrary.org/obo/UBERON_0012375) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [retrograde neuronal dense core vesicle transport](http://purl.obolibrary.org/obo/GO_1990049) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2013-02-19T13:31:44Z" +- [retrograde neuronal dense core vesicle transport](http://purl.obolibrary.org/obo/GO_1990049) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [goslim_synapse](http://purl.obolibrary.org/obo/go#goslim_synapse) +- Class: [retrograde neuronal dense core vesicle transport](http://purl.obolibrary.org/obo/GO_1990049) -### substantia propria of cornea `http://purl.obolibrary.org/obo/UBERON_0001777` -#### Removed -- [substantia propria of cornea](http://purl.obolibrary.org/obo/UBERON_0001777) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [retrograde neuronal dense core vesicle transport](http://purl.obolibrary.org/obo/GO_1990049) EquivalentTo [transport](http://purl.obolibrary.org/obo/GO_0006810) and ([occurs in](http://purl.obolibrary.org/obo/BFO_0000066) some [axon cytoplasm](http://purl.obolibrary.org/obo/GO_1904115)) and ([has target start location](http://purl.obolibrary.org/obo/RO_0002338) some [presynapse](http://purl.obolibrary.org/obo/GO_0098793)) and ([results in transport along](http://purl.obolibrary.org/obo/RO_0002341) some [microtubule](http://purl.obolibrary.org/obo/GO_0005874)) and ([has primary input](http://purl.obolibrary.org/obo/RO_0004009) some [neuronal dense core vesicle](http://purl.obolibrary.org/obo/GO_0098992)) +- [retrograde neuronal dense core vesicle transport](http://purl.obolibrary.org/obo/GO_1990049) SubClassOf [dense core granule cytoskeletal transport](http://purl.obolibrary.org/obo/GO_0099519) +- [retrograde neuronal dense core vesicle transport](http://purl.obolibrary.org/obo/GO_1990049) SubClassOf [has primary input](http://purl.obolibrary.org/obo/RO_0004009) some [neuronal dense core vesicle](http://purl.obolibrary.org/obo/GO_0098992) -### symbol `http://purl.obolibrary.org/obo/IAO_0000028` +- [retrograde neuronal dense core vesicle transport](http://purl.obolibrary.org/obo/GO_1990049) SubClassOf [vesicle transport along microtubule](http://purl.obolibrary.org/obo/GO_0047496) -#### Added -- [symbol](http://purl.obolibrary.org/obo/IAO_0000028) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "symbol"@en +- [retrograde neuronal dense core vesicle transport](http://purl.obolibrary.org/obo/GO_1990049) SubClassOf [retrograde axonal transport](http://purl.obolibrary.org/obo/GO_0008090) -- [symbol](http://purl.obolibrary.org/obo/IAO_0000028) [label](http://www.w3.org/2000/01/rdf-schema#label) "symbol"@en -- [symbol](http://purl.obolibrary.org/obo/IAO_0000028) [IAO_0000114](http://purl.obolibrary.org/obo/IAO_0000114) [pending final vetting](http://purl.obolibrary.org/obo/IAO_0000125) +### ribonucleoside triphosphate phosphatase activity `http://purl.obolibrary.org/obo/GO_0017111` +#### Removed +- [ribonucleoside triphosphate phosphatase activity](http://purl.obolibrary.org/obo/GO_0017111) [label](http://www.w3.org/2000/01/rdf-schema#label) "ribonucleoside triphosphate phosphatase activity" -- [symbol](http://purl.obolibrary.org/obo/IAO_0000028) [editor note](http://purl.obolibrary.org/obo/IAO_0000116) "20091104, MC: this needs work and will most probably change"@en +- [ribonucleoside triphosphate phosphatase activity](http://purl.obolibrary.org/obo/GO_0017111) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-8851110" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "NTPDase3 hydrolyzes nucleoside triphosphates" -- [symbol](http://purl.obolibrary.org/obo/IAO_0000028) [IAO_0000112](http://purl.obolibrary.org/obo/IAO_0000112) "a written proper name such as "OBI""@en +- [ribonucleoside triphosphate phosphatase activity](http://purl.obolibrary.org/obo/GO_0017111) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "EC:3.6.1.15" -- [symbol](http://purl.obolibrary.org/obo/IAO_0000028) [IAO_0000119](http://purl.obolibrary.org/obo/IAO_0000119) "based on Oxford English Dictionary"@en +- [ribonucleoside triphosphate phosphatase activity](http://purl.obolibrary.org/obo/GO_0017111) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [goslim_metagenomics](http://purl.obolibrary.org/obo/go#goslim_metagenomics) -- [symbol](http://purl.obolibrary.org/obo/IAO_0000028) [IAO_0000117](http://purl.obolibrary.org/obo/IAO_0000117) "PERSON: James A. Overton"@en +- [ribonucleoside triphosphate phosphatase activity](http://purl.obolibrary.org/obo/GO_0017111) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "MetaCyc:NUCLEOSIDE-TRIPHOSPHATASE-RXN" -- [symbol](http://purl.obolibrary.org/obo/IAO_0000028) [editor note](http://purl.obolibrary.org/obo/IAO_0000116) "2014-03-31: We would like to have a deeper analysis of 'mark' and 'sign' in the future (see https://github.com/information-artifact-ontology/IAO/issues/154)."@en +- [ribonucleoside triphosphate phosphatase activity](http://purl.obolibrary.org/obo/GO_0017111) [term tracker item](http://purl.obolibrary.org/obo/IAO_0000233) "https://github.com/geneontology/go-ontology/issues/21232"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI) -- [symbol](http://purl.obolibrary.org/obo/IAO_0000028) [IAO_0000112](http://purl.obolibrary.org/obo/IAO_0000112) "a serial number such as "12324X""@en +- [ribonucleoside triphosphate phosphatase activity](http://purl.obolibrary.org/obo/GO_0017111) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "nucleoside-5-triphosphate phosphohydrolase activity" -- [symbol](http://purl.obolibrary.org/obo/IAO_0000028) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "An information content entity that is a mark(s) or character(s) used as a conventional representation of another entity."@en +- [ribonucleoside triphosphate phosphatase activity](http://purl.obolibrary.org/obo/GO_0017111) [term tracker item](http://purl.obolibrary.org/obo/IAO_0000233) "https://github.com/geneontology/go-ontology/issues/23401"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI) -- [symbol](http://purl.obolibrary.org/obo/IAO_0000028) [IAO_0000117](http://purl.obolibrary.org/obo/IAO_0000117) "PERSON: Jonathan Rees"@en +- [ribonucleoside triphosphate phosphatase activity](http://purl.obolibrary.org/obo/GO_0017111) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-8851538" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "NTPDase8 hydrolyzes nucleoside triphosphates" -- [symbol](http://purl.obolibrary.org/obo/IAO_0000028) [IAO_0000112](http://purl.obolibrary.org/obo/IAO_0000112) "a stop sign"@en +- [ribonucleoside triphosphate phosphatase activity](http://purl.obolibrary.org/obo/GO_0017111) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "nucleoside-triphosphatase activity" -- Class: [symbol](http://purl.obolibrary.org/obo/IAO_0000028) +- [ribonucleoside triphosphate phosphatase activity](http://purl.obolibrary.org/obo/GO_0017111) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "RHEA:23680" -- AnnotationProperty: [symbol](http://purl.obolibrary.org/obo/IAO_0000028) +- [ribonucleoside triphosphate phosphatase activity](http://purl.obolibrary.org/obo/GO_0017111) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "NTPase activity" -- [symbol](http://purl.obolibrary.org/obo/IAO_0000028) SubClassOf [information content entity](http://purl.obolibrary.org/obo/IAO_0000030) +- [ribonucleoside triphosphate phosphatase activity](http://purl.obolibrary.org/obo/GO_0017111) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "nucleoside 5-triphosphatase activity" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "EC:3.6.1.15" +- [ribonucleoside triphosphate phosphatase activity](http://purl.obolibrary.org/obo/GO_0017111) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "nucleoside triphosphate phosphohydrolase activity" -### synapsed_by `http://purl.obolibrary.org/obo/uberon/core#synapsed_by` -#### Removed -- ObjectProperty: [synapsed_by](http://purl.obolibrary.org/obo/uberon/core#synapsed_by) +- [ribonucleoside triphosphate phosphatase activity](http://purl.obolibrary.org/obo/GO_0017111) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "apyrase activity" +- [ribonucleoside triphosphate phosphatase activity](http://purl.obolibrary.org/obo/GO_0017111) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [goslim_chembl](http://purl.obolibrary.org/obo/go#goslim_chembl) +- [ribonucleoside triphosphate phosphatase activity](http://purl.obolibrary.org/obo/GO_0017111) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "molecular_function" -### synchronous hermaphroditic organism `http://purl.obolibrary.org/obo/UBERON_0010899` -#### Removed -- [synchronous hermaphroditic organism](http://purl.obolibrary.org/obo/UBERON_0010899) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [ribonucleoside triphosphate phosphatase activity](http://purl.obolibrary.org/obo/GO_0017111) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "nucleoside triphosphate hydrolase activity" +- [ribonucleoside triphosphate phosphatase activity](http://purl.obolibrary.org/obo/GO_0017111) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-8851494" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "NTPDase7 hydrolyzes nucleoside triphosphates" +- [ribonucleoside triphosphate phosphatase activity](http://purl.obolibrary.org/obo/GO_0017111) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-8850846" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "NTPDase1 hydrolyzes nucleoside triphosphates" -### syndecan-1 `http://purl.obolibrary.org/obo/PR_000001935` +- [ribonucleoside triphosphate phosphatase activity](http://purl.obolibrary.org/obo/GO_0017111) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Catalysis of the reaction: a ribonucleoside triphosphate + H2O = a ribonucleoside diphosphate + H+ + phosphate." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "RHEA:23680" -#### Added -- [syndecan-1](http://purl.obolibrary.org/obo/PR_000001935) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [syndecan-1 (human)](http://purl.obolibrary.org/obo/PR_P18827) +- [ribonucleoside triphosphate phosphatase activity](http://purl.obolibrary.org/obo/GO_0017111) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-8851234" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "NTPDase4 hydrolyzes nucleoside triphosphates" +- [ribonucleoside triphosphate phosphatase activity](http://purl.obolibrary.org/obo/GO_0017111) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0017111" -### synovial membrane of synovial joint `http://purl.obolibrary.org/obo/UBERON_0002018` -#### Removed -- [synovial membrane of synovial joint](http://purl.obolibrary.org/obo/UBERON_0002018) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000) +- [ribonucleoside triphosphate phosphatase activity](http://purl.obolibrary.org/obo/GO_0017111) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-8851089" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "NTPDase2 hydrolyzes nucleoside triphosphates" +- [ribonucleoside triphosphate phosphatase activity](http://purl.obolibrary.org/obo/GO_0017111) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "nucleoside triphosphate phosphatase activity" +- [ribonucleoside triphosphate phosphatase activity](http://purl.obolibrary.org/obo/GO_0017111) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "nucleoside triphosphatase activity" -### tachykinin-3 `http://purl.obolibrary.org/obo/PR_000016004` +- Class: [ribonucleoside triphosphate phosphatase activity](http://purl.obolibrary.org/obo/GO_0017111) -#### Added -- [tachykinin-3](http://purl.obolibrary.org/obo/PR_000016004) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [tachykinin-3 (human)](http://purl.obolibrary.org/obo/PR_Q9UHF0) +- [ribonucleoside triphosphate phosphatase activity](http://purl.obolibrary.org/obo/GO_0017111) SubClassOf [has participant](http://purl.obolibrary.org/obo/RO_0000057) some [CHEBI_57930](http://purl.obolibrary.org/obo/CHEBI_57930) +- [ribonucleoside triphosphate phosphatase activity](http://purl.obolibrary.org/obo/GO_0017111) SubClassOf [has participant](http://purl.obolibrary.org/obo/RO_0000057) some [CHEBI_43474](http://purl.obolibrary.org/obo/CHEBI_43474) -### tartrate-resistant acid phosphatase type 5 `http://purl.obolibrary.org/obo/PR_000001937` +- [ribonucleoside triphosphate phosphatase activity](http://purl.obolibrary.org/obo/GO_0017111) SubClassOf [has participant](http://purl.obolibrary.org/obo/RO_0000057) some [CHEBI_15377](http://purl.obolibrary.org/obo/CHEBI_15377) -#### Added -- [tartrate-resistant acid phosphatase type 5](http://purl.obolibrary.org/obo/PR_000001937) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [tartrate-resistant acid phosphatase type 5 (human)](http://purl.obolibrary.org/obo/PR_P13686) +- [ribonucleoside triphosphate phosphatase activity](http://purl.obolibrary.org/obo/GO_0017111) SubClassOf [has participant](http://purl.obolibrary.org/obo/RO_0000057) some [CHEBI_61557](http://purl.obolibrary.org/obo/CHEBI_61557) +- [ribonucleoside triphosphate phosphatase activity](http://purl.obolibrary.org/obo/GO_0017111) SubClassOf [has participant](http://purl.obolibrary.org/obo/RO_0000057) some [CHEBI_15378](http://purl.obolibrary.org/obo/CHEBI_15378) -### telencephalic ventricle `http://purl.obolibrary.org/obo/UBERON_0002285` -#### Removed -- [telencephalic ventricle](http://purl.obolibrary.org/obo/UBERON_0002285) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [ribonucleoside triphosphate phosphatase activity](http://purl.obolibrary.org/obo/GO_0017111) SubClassOf [pyrophosphatase activity](http://purl.obolibrary.org/obo/GO_0016462) -### tendon sheath `http://purl.obolibrary.org/obo/UBERON_0000304` +### salivary gland cell autophagic cell death `http://purl.obolibrary.org/obo/GO_0035071` #### Removed -- [tendon sheath](http://purl.obolibrary.org/obo/UBERON_0000304) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) - +- [salivary gland cell autophagic cell death](http://purl.obolibrary.org/obo/GO_0035071) [label](http://www.w3.org/2000/01/rdf-schema#label) "salivary gland cell autophagic cell death" +- [salivary gland cell autophagic cell death](http://purl.obolibrary.org/obo/GO_0035071) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" -### term imported `http://purl.obolibrary.org/obo/IAO_0000228` +- [salivary gland cell autophagic cell death](http://purl.obolibrary.org/obo/GO_0035071) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "programmed cell death of salivary gland cells by autophagy" -#### Added -- [term imported](http://purl.obolibrary.org/obo/IAO_0000228) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "term imported"@en +- [salivary gland cell autophagic cell death](http://purl.obolibrary.org/obo/GO_0035071) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "salivary gland cell death" -- [term imported](http://purl.obolibrary.org/obo/IAO_0000228) [editor note](http://purl.obolibrary.org/obo/IAO_0000116) "This is to be used when the original term has been replaced by a term imported from an other ontology. An editor note should indicate what is the URI of the new term to use."@en +- [salivary gland cell autophagic cell death](http://purl.obolibrary.org/obo/GO_0035071) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "salivary gland cell programmed cell death by autophagy" -- [term imported](http://purl.obolibrary.org/obo/IAO_0000228) [label](http://www.w3.org/2000/01/rdf-schema#label) "term imported"@en +- [salivary gland cell autophagic cell death](http://purl.obolibrary.org/obo/GO_0035071) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "autophagic cell death of salivary gland cells" -- Individual: [term imported](http://purl.obolibrary.org/obo/IAO_0000228) +- [salivary gland cell autophagic cell death](http://purl.obolibrary.org/obo/GO_0035071) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0035071" +- [salivary gland cell autophagic cell death](http://purl.obolibrary.org/obo/GO_0035071) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The stage-specific programmed cell death of salivary gland cells during salivary gland histolysis." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:bf" -### term replaced by `http://purl.obolibrary.org/obo/IAO_0100001` + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:10882130" -#### Added -- [term replaced by](http://purl.obolibrary.org/obo/IAO_0100001) [IAO_0000114](http://purl.obolibrary.org/obo/IAO_0000114) [pending final vetting](http://purl.obolibrary.org/obo/IAO_0000125) + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:mtg_apoptosis" -- [term replaced by](http://purl.obolibrary.org/obo/IAO_0100001) [IAO_0000119](http://purl.obolibrary.org/obo/IAO_0000119) "Person:Alan Ruttenberg"@en +- Class: [salivary gland cell autophagic cell death](http://purl.obolibrary.org/obo/GO_0035071) -- [term replaced by](http://purl.obolibrary.org/obo/IAO_0100001) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "term replaced by"@en +- [salivary gland cell autophagic cell death](http://purl.obolibrary.org/obo/GO_0035071) EquivalentTo [cell death](http://purl.obolibrary.org/obo/GO_0008219) and ([results in maturation of](http://purl.obolibrary.org/obo/RO_0002299) some [saliva-secreting gland](http://purl.obolibrary.org/obo/UBERON_0001044)) -- [term replaced by](http://purl.obolibrary.org/obo/IAO_0100001) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "Add as annotation triples in the granting ontology"@en +- [salivary gland cell autophagic cell death](http://purl.obolibrary.org/obo/GO_0035071) SubClassOf [programmed cell death involved in cell development](http://purl.obolibrary.org/obo/GO_0010623) -- [term replaced by](http://purl.obolibrary.org/obo/IAO_0100001) [IAO_0000117](http://purl.obolibrary.org/obo/IAO_0000117) "Person:Alan Ruttenberg"@en +- [salivary gland cell autophagic cell death](http://purl.obolibrary.org/obo/GO_0035071) SubClassOf [results in maturation of](http://purl.obolibrary.org/obo/RO_0002299) some [saliva-secreting gland](http://purl.obolibrary.org/obo/UBERON_0001044) -- [term replaced by](http://purl.obolibrary.org/obo/IAO_0100001) [label](http://www.w3.org/2000/01/rdf-schema#label) "term replaced by"@en +- [salivary gland cell autophagic cell death](http://purl.obolibrary.org/obo/GO_0035071) SubClassOf [autophagic cell death](http://purl.obolibrary.org/obo/GO_0048102) -- [term replaced by](http://purl.obolibrary.org/obo/IAO_0100001) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Use on obsolete terms, relating the term to another term that can be used as a substitute"@en +- [salivary gland cell autophagic cell death](http://purl.obolibrary.org/obo/GO_0035071) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [salivary gland histolysis](http://purl.obolibrary.org/obo/GO_0035070) -### term split `http://purl.obolibrary.org/obo/IAO_0000229` -#### Added -- [term split](http://purl.obolibrary.org/obo/IAO_0000229) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "term split"@en +### salivary gland histolysis `http://purl.obolibrary.org/obo/GO_0035070` +#### Removed +- [salivary gland histolysis](http://purl.obolibrary.org/obo/GO_0035070) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" -- [term split](http://purl.obolibrary.org/obo/IAO_0000229) [label](http://www.w3.org/2000/01/rdf-schema#label) "term split"@en +- [salivary gland histolysis](http://purl.obolibrary.org/obo/GO_0035070) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The stage-specific break down of the larval salivary glands during Drosophila metamorphosis, to allow replacement of larval structures by tissues and structures that form the adult fly." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dph" -- [term split](http://purl.obolibrary.org/obo/IAO_0000229) [editor note](http://purl.obolibrary.org/obo/IAO_0000116) "This is to be used when a term has been split in two or more new terms. An editor note should indicate the reason for the split and indicate the URIs of the new terms created."@en + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:bf" -- Individual: [term split](http://purl.obolibrary.org/obo/IAO_0000229) + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:9409683" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:mtg_apoptosis" -### term tracker item `http://purl.obolibrary.org/obo/IAO_0000233` +- [salivary gland histolysis](http://purl.obolibrary.org/obo/GO_0035070) [label](http://www.w3.org/2000/01/rdf-schema#label) "salivary gland histolysis" -#### Added -- [term tracker item](http://purl.obolibrary.org/obo/IAO_0000233) [label](http://www.w3.org/2000/01/rdf-schema#label) "term tracker item"@en +- [salivary gland histolysis](http://purl.obolibrary.org/obo/GO_0035070) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0035070" -- [term tracker item](http://purl.obolibrary.org/obo/IAO_0000233) [IAO_0000119](http://purl.obolibrary.org/obo/IAO_0000119) "Person: Jie Zheng, Chris Stoeckert, Alan Ruttenberg"@en +- [salivary gland histolysis](http://purl.obolibrary.org/obo/GO_0035070) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "salivary gland regression" -- [term tracker item](http://purl.obolibrary.org/obo/IAO_0000233) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "The 'tracker item' can associate a tracker with a specific ontology term."@en +- Class: [salivary gland histolysis](http://purl.obolibrary.org/obo/GO_0035070) -- [term tracker item](http://purl.obolibrary.org/obo/IAO_0000233) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "An IRI or similar locator for a request or discussion of an ontology term."@en +- [salivary gland histolysis](http://purl.obolibrary.org/obo/GO_0035070) EquivalentTo [anatomical structure regression](http://purl.obolibrary.org/obo/GO_0060033) and ([results in morphogenesis of](http://purl.obolibrary.org/obo/RO_0002298) some [saliva-secreting gland](http://purl.obolibrary.org/obo/UBERON_0001044)) -- [term tracker item](http://purl.obolibrary.org/obo/IAO_0000233) [IAO_0000114](http://purl.obolibrary.org/obo/IAO_0000114) [pending final vetting](http://purl.obolibrary.org/obo/IAO_0000125) +- [salivary gland histolysis](http://purl.obolibrary.org/obo/GO_0035070) SubClassOf [anatomical structure regression](http://purl.obolibrary.org/obo/GO_0060033) -- [term tracker item](http://purl.obolibrary.org/obo/IAO_0000233) [IAO_0000117](http://purl.obolibrary.org/obo/IAO_0000117) "Person: Jie Zheng, Chris Stoeckert, Alan Ruttenberg"@en +- [salivary gland histolysis](http://purl.obolibrary.org/obo/GO_0035070) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [metamorphosis](http://purl.obolibrary.org/obo/GO_0007552) -- [term tracker item](http://purl.obolibrary.org/obo/IAO_0000233) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "term tracker item"@en +- [salivary gland histolysis](http://purl.obolibrary.org/obo/GO_0035070) SubClassOf [salivary gland morphogenesis](http://purl.obolibrary.org/obo/GO_0007435) -- [term tracker item](http://purl.obolibrary.org/obo/IAO_0000233) [IAO_0000112](http://purl.obolibrary.org/obo/IAO_0000112) "the URI for an OBI Terms ticket at sourceforge, such as https://sourceforge.net/p/obi/obi-terms/772/"@en +- [salivary gland histolysis](http://purl.obolibrary.org/obo/GO_0035070) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [instar larval or pupal morphogenesis](http://purl.obolibrary.org/obo/GO_0048707) +- [salivary gland histolysis](http://purl.obolibrary.org/obo/GO_0035070) SubClassOf [post-embryonic animal morphogenesis](http://purl.obolibrary.org/obo/GO_0009886) -### terminal bronchiole epithelium `http://purl.obolibrary.org/obo/UBERON_0001958` -#### Removed -- [terminal bronchiole epithelium](http://purl.obolibrary.org/obo/UBERON_0001958) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +### secondary pulmonary lobule `http://purl.obolibrary.org/obo/UBERON_0010369` -### terminal part of digestive tract `http://purl.obolibrary.org/obo/UBERON_0006866` -#### Removed -- [terminal part of digestive tract](http://purl.obolibrary.org/obo/UBERON_0006866) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +#### Added +- [secondary pulmonary lobule](http://purl.obolibrary.org/obo/UBERON_0010369) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [human_reference_atlas](http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas) +- [secondary pulmonary lobule](http://purl.obolibrary.org/obo/UBERON_0010369) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "lobulus pulmonis secondarius" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "FMA:7414" + - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [LATIN](http://purl.obolibrary.org/obo/uberon/core#LATIN) -### terms merged `http://purl.obolibrary.org/obo/IAO_0000227` + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "FMA:TA" -#### Added -- [terms merged](http://purl.obolibrary.org/obo/IAO_0000227) [label](http://www.w3.org/2000/01/rdf-schema#label) "terms merged"@en +- [secondary pulmonary lobule](http://purl.obolibrary.org/obo/UBERON_0010369) [present_in_taxon](http://purl.obolibrary.org/obo/RO_0002175) [Homo sapiens](http://purl.obolibrary.org/obo/NCBITaxon_9606) -- [terms merged](http://purl.obolibrary.org/obo/IAO_0000227) [editor note](http://purl.obolibrary.org/obo/IAO_0000116) "An editor note should explain what were the merged terms and the reason for the merge."@en +- [secondary pulmonary lobule](http://purl.obolibrary.org/obo/UBERON_0010369) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A unit of lung supplied by three to five terminal bronchioles and contained by fibrous septa." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:3259815" -- [terms merged](http://purl.obolibrary.org/obo/IAO_0000227) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "terms merged"@en +- [secondary pulmonary lobule](http://purl.obolibrary.org/obo/UBERON_0010369) [UBPROP_0000001](http://purl.obolibrary.org/obo/UBPROP_0000001) "a pyramidal mass of lung tissue with sides that are bounded by the incomplete interlobular connective tissue septa and with a base, which is 1-2 cm in diameter, which usually faces the pleural surface of the lung; lobules that occupy a more central position in the lung are not well defined and are considered to consist of three to five pulmonary acini with proximate terminal bronchioles." + - [source](http://www.geneontology.org/formats/oboInOwl#source) "http://medical-dictionary.thefreedictionary.com/secondary+pulmonary+lobule" -- Individual: [terms merged](http://purl.obolibrary.org/obo/IAO_0000227) +- [secondary pulmonary lobule](http://purl.obolibrary.org/obo/UBERON_0010369) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "FMA:7414" +- [secondary pulmonary lobule](http://purl.obolibrary.org/obo/UBERON_0010369) [id](http://www.geneontology.org/formats/oboInOwl#id) "UBERON:0010369" -### tetrapod frontal bone primordium `http://purl.obolibrary.org/obo/UBERON_0006236` -#### Removed -- [tetrapod frontal bone primordium](http://purl.obolibrary.org/obo/UBERON_0006236) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [secondary pulmonary lobule](http://purl.obolibrary.org/obo/UBERON_0010369) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "uberon" +- [secondary pulmonary lobule](http://purl.obolibrary.org/obo/UBERON_0010369) [label](http://www.w3.org/2000/01/rdf-schema#label) "secondary pulmonary lobule" +- Class: [secondary pulmonary lobule](http://purl.obolibrary.org/obo/UBERON_0010369) -### thalamic excitatory neuron `http://purl.obolibrary.org/obo/CL_4023068` -#### Removed -- [thalamic excitatory neuron](http://purl.obolibrary.org/obo/CL_4023068) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [secondary pulmonary lobule](http://purl.obolibrary.org/obo/UBERON_0010369) SubClassOf [pulmonary lobule](http://purl.obolibrary.org/obo/UBERON_0010368) + - [source](http://www.geneontology.org/formats/oboInOwl#source) "FMA" +- [secondary pulmonary lobule](http://purl.obolibrary.org/obo/UBERON_0010369) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [lung parenchyma](http://purl.obolibrary.org/obo/UBERON_0008946) + - [source](http://www.geneontology.org/formats/oboInOwl#source) "FMA" -### theca cell layer `http://purl.obolibrary.org/obo/UBERON_0000155` +### secretory granule maturation `http://purl.obolibrary.org/obo/GO_0061792` #### Removed -- [theca cell layer](http://purl.obolibrary.org/obo/UBERON_0000155) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [secretory granule maturation](http://purl.obolibrary.org/obo/GO_0061792) SubClassOf [developmental maturation](http://purl.obolibrary.org/obo/GO_0021700) +#### Added +- [secretory granule maturation](http://purl.obolibrary.org/obo/GO_0061792) SubClassOf [anatomical structure maturation](http://purl.obolibrary.org/obo/GO_0071695) -### thoracic segment of trunk `http://purl.obolibrary.org/obo/UBERON_0000915` -#### Removed -- [thoracic segment of trunk](http://purl.obolibrary.org/obo/UBERON_0000915) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000) +### segmental bronchus `http://purl.obolibrary.org/obo/UBERON_0002184` +#### Added +- [segmental bronchus](http://purl.obolibrary.org/obo/UBERON_0002184) SubClassOf [overlaps](http://purl.obolibrary.org/obo/RO_0002131) some [bronchopulmonary segment](http://purl.obolibrary.org/obo/UBERON_8600017) -### thrombomodulin `http://purl.obolibrary.org/obo/PR_000002105` +### sequestering of calcium ion `http://purl.obolibrary.org/obo/GO_0051208` #### Added -- [thrombomodulin](http://purl.obolibrary.org/obo/PR_000002105) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [thrombomodulin (human)](http://purl.obolibrary.org/obo/PR_P07204) +- [sequestering of calcium ion](http://purl.obolibrary.org/obo/GO_0051208) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "negative regulation of calcium ion (Ca2+) transport" +- [sequestering of calcium ion](http://purl.obolibrary.org/obo/GO_0051208) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "calcium ion (Ca2+) sequestering" -### thymic plasmacytoid dendritic cell `http://purl.obolibrary.org/obo/CL_0000942` -#### Removed -- [thymic plasmacytoid dendritic cell](http://purl.obolibrary.org/obo/CL_0000942) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [sequestering of calcium ion](http://purl.obolibrary.org/obo/GO_0051208) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "storage of calcium ion (Ca2+)" +- [sequestering of calcium ion](http://purl.obolibrary.org/obo/GO_0051208) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "biological_process" +- [sequestering of calcium ion](http://purl.obolibrary.org/obo/GO_0051208) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "calcium ion (Ca2+) retention" -### thymus corticomedullary boundary `http://purl.obolibrary.org/obo/UBERON_0003988` -#### Removed -- [thymus corticomedullary boundary](http://purl.obolibrary.org/obo/UBERON_0003988) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [sequestering of calcium ion](http://purl.obolibrary.org/obo/GO_0051208) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "sequestration of calcium ion (Ca2+)" +- [sequestering of calcium ion](http://purl.obolibrary.org/obo/GO_0051208) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0051208" +- [sequestering of calcium ion](http://purl.obolibrary.org/obo/GO_0051208) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "calcium ion storage activity" -### thymus epithelium `http://purl.obolibrary.org/obo/UBERON_0003846` -#### Removed -- [thymus epithelium](http://purl.obolibrary.org/obo/UBERON_0003846) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [sequestering of calcium ion](http://purl.obolibrary.org/obo/GO_0051208) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "sequestering of calcium ion (Ca2+)" +- [sequestering of calcium ion](http://purl.obolibrary.org/obo/GO_0051208) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The process of binding or confining calcium ions such that they are separated from other components of a biological system." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:ai" +- [sequestering of calcium ion](http://purl.obolibrary.org/obo/GO_0051208) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "calcium ion (Ca2+) sequestration" -### thymus lobule `http://purl.obolibrary.org/obo/UBERON_0002125` -#### Removed -- [thymus lobule](http://purl.obolibrary.org/obo/UBERON_0002125) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [sequestering of calcium ion](http://purl.obolibrary.org/obo/GO_0051208) [label](http://www.w3.org/2000/01/rdf-schema#label) "sequestering of calcium ion" +- [sequestering of calcium ion](http://purl.obolibrary.org/obo/GO_0051208) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "calcium ion (Ca2+) storage" +- [sequestering of calcium ion](http://purl.obolibrary.org/obo/GO_0051208) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "retention of calcium ion (Ca2+)" -### thyroid diverticulum `http://purl.obolibrary.org/obo/UBERON_0007689` -#### Removed -- [thyroid diverticulum](http://purl.obolibrary.org/obo/UBERON_0007689) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- Class: [sequestering of calcium ion](http://purl.obolibrary.org/obo/GO_0051208) +- [sequestering of calcium ion](http://purl.obolibrary.org/obo/GO_0051208) EquivalentTo [maintenance of location](http://purl.obolibrary.org/obo/GO_0051235) and ([has primary input](http://purl.obolibrary.org/obo/RO_0004009) some [CHEBI_39124](http://purl.obolibrary.org/obo/CHEBI_39124)) +- [sequestering of calcium ion](http://purl.obolibrary.org/obo/GO_0051208) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [intracellular calcium ion homeostasis](http://purl.obolibrary.org/obo/GO_0006874) -### to be replaced with external ontology term `http://purl.obolibrary.org/obo/IAO_0000423` +- [sequestering of calcium ion](http://purl.obolibrary.org/obo/GO_0051208) SubClassOf [maintenance of location in cell](http://purl.obolibrary.org/obo/GO_0051651) -#### Added -- [to be replaced with external ontology term](http://purl.obolibrary.org/obo/IAO_0000423) [IAO_0000117](http://purl.obolibrary.org/obo/IAO_0000117) "Alan Ruttenberg"@en +- [sequestering of calcium ion](http://purl.obolibrary.org/obo/GO_0051208) SubClassOf [has primary input](http://purl.obolibrary.org/obo/RO_0004009) some [CHEBI_39124](http://purl.obolibrary.org/obo/CHEBI_39124) -- [to be replaced with external ontology term](http://purl.obolibrary.org/obo/IAO_0000423) [IAO_0000119](http://purl.obolibrary.org/obo/IAO_0000119) "group:OBI"@en -- [to be replaced with external ontology term](http://purl.obolibrary.org/obo/IAO_0000423) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Terms with this status should eventually replaced with a term from another ontology."@en +### serine/threonine protein kinase complex `http://purl.obolibrary.org/obo/GO_1902554` +#### Removed +- [serine/threonine protein kinase complex](http://purl.obolibrary.org/obo/GO_1902554) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "cellular_component" -- [to be replaced with external ontology term](http://purl.obolibrary.org/obo/IAO_0000423) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "to be replaced with external ontology term"@en +- [serine/threonine protein kinase complex](http://purl.obolibrary.org/obo/GO_1902554) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2013-12-06T16:06:12Z" -- [to be replaced with external ontology term](http://purl.obolibrary.org/obo/IAO_0000423) [label](http://www.w3.org/2000/01/rdf-schema#label) "to be replaced with external ontology term"@en +- [serine/threonine protein kinase complex](http://purl.obolibrary.org/obo/GO_1902554) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "An example is IRE1 in S. cerevisiae (UniProt ID P32361) in PMID:18191223 (inferred from direct assay)." -- Individual: [to be replaced with external ontology term](http://purl.obolibrary.org/obo/IAO_0000423) +- [serine/threonine protein kinase complex](http://purl.obolibrary.org/obo/GO_1902554) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A protein complex which is capable of protein serine/threonine kinase activity." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:18191223" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:bhm" -### tooth bud `http://purl.obolibrary.org/obo/UBERON_0008281` -#### Removed -- [tooth bud](http://purl.obolibrary.org/obo/UBERON_0008281) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:TermGenie" +- [serine/threonine protein kinase complex](http://purl.obolibrary.org/obo/GO_1902554) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:1902554" +- [serine/threonine protein kinase complex](http://purl.obolibrary.org/obo/GO_1902554) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "bhm" -### trabecula carnea `http://purl.obolibrary.org/obo/UBERON_0002511` -#### Removed -- [trabecula carnea](http://purl.obolibrary.org/obo/UBERON_0002511) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [serine/threonine protein kinase complex](http://purl.obolibrary.org/obo/GO_1902554) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "PDR16 complex dimer" +- [serine/threonine protein kinase complex](http://purl.obolibrary.org/obo/GO_1902554) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "PDR16 complex homodimer" +- [serine/threonine protein kinase complex](http://purl.obolibrary.org/obo/GO_1902554) [label](http://www.w3.org/2000/01/rdf-schema#label) "serine/threonine protein kinase complex" -### trachea `http://purl.obolibrary.org/obo/UBERON_0003126` -#### Removed -- [trachea](http://purl.obolibrary.org/obo/UBERON_0003126) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- Class: [serine/threonine protein kinase complex](http://purl.obolibrary.org/obo/GO_1902554) +- [serine/threonine protein kinase complex](http://purl.obolibrary.org/obo/GO_1902554) EquivalentTo [protein-containing complex](http://purl.obolibrary.org/obo/GO_0032991) and ([capable of](http://purl.obolibrary.org/obo/RO_0002215) some [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674)) +- [serine/threonine protein kinase complex](http://purl.obolibrary.org/obo/GO_1902554) SubClassOf [capable of](http://purl.obolibrary.org/obo/RO_0002215) some [protein serine/threonine kinase activity](http://purl.obolibrary.org/obo/GO_0004674) -### trachea connective tissue `http://purl.obolibrary.org/obo/UBERON_0003571` -#### Removed -- [trachea connective tissue](http://purl.obolibrary.org/obo/UBERON_0003571) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [serine/threonine protein kinase complex](http://purl.obolibrary.org/obo/GO_1902554) SubClassOf [protein kinase complex](http://purl.obolibrary.org/obo/GO_1902911) -### trans-acting T-cell-specific transcription factor GATA-3 `http://purl.obolibrary.org/obo/PR_000001941` +### small bistratified retinal ganglion cell `http://purl.obolibrary.org/obo/CL_4033053` #### Added -- [trans-acting T-cell-specific transcription factor GATA-3](http://purl.obolibrary.org/obo/PR_000001941) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [trans-acting T-cell-specific transcription factor GATA-3 (human)](http://purl.obolibrary.org/obo/PR_P23771) +- [small bistratified retinal ganglion cell](http://purl.obolibrary.org/obo/CL_4033053) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "sbRGC" + - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation) + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:34093409" -### transcription factor PU.1 `http://purl.obolibrary.org/obo/PR_000001944` +- [small bistratified retinal ganglion cell](http://purl.obolibrary.org/obo/CL_4033053) [date](http://purl.org/dc/terms/date) "2023-08-08T12:43:56Z"^^[dateTime](http://www.w3.org/2001/XMLSchema#dateTime) -#### Added -- [transcription factor PU.1](http://purl.obolibrary.org/obo/PR_000001944) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [transcription factor PU.1 (human)](http://purl.obolibrary.org/obo/PR_P17947) +- [small bistratified retinal ganglion cell](http://purl.obolibrary.org/obo/CL_4033053) [contributor](http://purl.org/dc/terms/contributor) [0000-0001-6677-8489](https://orcid.org/0000-0001-6677-8489) +- [small bistratified retinal ganglion cell](http://purl.obolibrary.org/obo/CL_4033053) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "small bistratified cell" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:32032773" -### transcription factor SOX-2 `http://purl.obolibrary.org/obo/PR_000015426` +- [small bistratified retinal ganglion cell](http://purl.obolibrary.org/obo/CL_4033053) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "small bistratified cell, blue-ON/yellow-OFF ganglion cell" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1002/cne.22183" -#### Added -- [transcription factor SOX-2](http://purl.obolibrary.org/obo/PR_000015426) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [transcription factor SOX-2 (human)](http://purl.obolibrary.org/obo/PR_P48431) +- [small bistratified retinal ganglion cell](http://purl.obolibrary.org/obo/CL_4033053) [label](http://www.w3.org/2000/01/rdf-schema#label) "small bistratified retinal ganglion cell" +- [small bistratified retinal ganglion cell](http://purl.obolibrary.org/obo/CL_4033053) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "Polyak's shrub cell" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:32032773" -### transferrin receptor protein 1 `http://purl.obolibrary.org/obo/PR_000001945` +- [small bistratified retinal ganglion cell](http://purl.obolibrary.org/obo/CL_4033053) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "SBS ganglion cell" + - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation) -#### Added -- [transferrin receptor protein 1](http://purl.obolibrary.org/obo/PR_000001945) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [transferrin receptor protein 1 (human)](http://purl.obolibrary.org/obo/PR_P02786) + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:32032773" +- [small bistratified retinal ganglion cell](http://purl.obolibrary.org/obo/CL_4033053) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A bistratfied retinal ganglion cell with a small dendritic field that has dendrites in the ON and OFF sublamina of the retinal inner plexiform layer and carries blue-ON/yellow-OFF signals. This cell receives bipolar and amacrine input to both the OFF and ON dendritic tree." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:32032773" -### transit amplifying cell `http://purl.obolibrary.org/obo/CL_0009010` -#### Removed -- [transit amplifying cell](http://purl.obolibrary.org/obo/CL_0009010) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- Class: [small bistratified retinal ganglion cell](http://purl.obolibrary.org/obo/CL_4033053) +- [small bistratified retinal ganglion cell](http://purl.obolibrary.org/obo/CL_4033053) SubClassOf [has soma location](http://purl.obolibrary.org/obo/RO_0002100) some [ganglionic layer of retina](http://purl.obolibrary.org/obo/UBERON_0001792) +- [small bistratified retinal ganglion cell](http://purl.obolibrary.org/obo/CL_4033053) SubClassOf [bistratified retinal ganglion cell](http://purl.obolibrary.org/obo/CL_0003001) -### transmembrane emp24 domain-containing protein 1 `http://purl.obolibrary.org/obo/PR_000016401` + +### smooth muscle tissue of respiratory bronchiole `http://purl.obolibrary.org/obo/UBERON_0004517` #### Added -- [transmembrane emp24 domain-containing protein 1](http://purl.obolibrary.org/obo/PR_000016401) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [transmembrane emp24 domain-containing protein 1 (human)](http://purl.obolibrary.org/obo/PR_Q13445) +- [smooth muscle tissue of respiratory bronchiole](http://purl.obolibrary.org/obo/UBERON_0004517) [contributor](http://purl.org/dc/terms/contributor) [0000-0001-6677-8489](https://orcid.org/0000-0001-6677-8489) +- [smooth muscle tissue of respiratory bronchiole](http://purl.obolibrary.org/obo/UBERON_0004517) SubClassOf [has part](http://purl.obolibrary.org/obo/BFO_0000051) some [bronchiolar smooth muscle cell](http://purl.obolibrary.org/obo/CL_4033017) -### transudate `http://purl.obolibrary.org/obo/UBERON_0007779` -#### Removed -- [transudate](http://purl.obolibrary.org/obo/UBERON_0007779) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +### smooth muscle tissue of terminal bronchiole `http://purl.obolibrary.org/obo/UBERON_0004516` + +#### Added +- [smooth muscle tissue of terminal bronchiole](http://purl.obolibrary.org/obo/UBERON_0004516) [contributor](http://purl.org/dc/terms/contributor) [0000-0001-6677-8489](https://orcid.org/0000-0001-6677-8489) + +- [smooth muscle tissue of terminal bronchiole](http://purl.obolibrary.org/obo/UBERON_0004516) SubClassOf [has part](http://purl.obolibrary.org/obo/BFO_0000051) some [bronchiolar smooth muscle cell](http://purl.obolibrary.org/obo/CL_4033017) -### transverse colon `http://purl.obolibrary.org/obo/UBERON_0001157` +### source `http://purl.org/dc/elements/1.1/source` #### Removed -- [transverse colon](http://purl.obolibrary.org/obo/UBERON_0001157) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- AnnotationProperty: [source](http://purl.org/dc/elements/1.1/source) -### trigeminal nerve `http://purl.obolibrary.org/obo/UBERON_0001645` +### starburst amacrine cell `http://purl.obolibrary.org/obo/CL_0004232` #### Removed -- [trigeminal nerve](http://purl.obolibrary.org/obo/UBERON_0001645) SubClassOf [neuron projection bundle](http://purl.obolibrary.org/obo/CARO_0001001) +- [starburst amacrine cell](http://purl.obolibrary.org/obo/CL_0004232) SubClassOf [retina horizontal cell](http://purl.obolibrary.org/obo/CL_0000745) -### trophectoderm `http://purl.obolibrary.org/obo/UBERON_0004345` +### striosomal D1 medium spiny neuron `http://purl.obolibrary.org/obo/CL_4030048` #### Removed -- [trophectoderm](http://purl.obolibrary.org/obo/UBERON_0004345) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [striosomal D1 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030048) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A DRD1-expressing medium spiny neuron that is part of a striosome of dorsal striatum." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) [j.cub.2021.10.015](DOI:10.1016/j.cub.2021.10.015) +- [striosomal D1 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030048) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "striosome D1 medium spiny neuron" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) [j.cub.2021.10.015](DOI:10.1016/j.cub.2021.10.015) +- [striosomal D1 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030048) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "In Rhesus macaques, both striosomal D1 and D2 medium spiny neuron (MSN) cell types have been noted to have enriched gene expression of the following: KCNT1, KHDRBS3, FAM163A, BACH2, and KCNIP1. Striosomal MSN activations have been noted to influence cognitive and emotional decision making and value-based learning. In contrast to matrix MSNs, striosomal MSNs receive input from limbic territories, including the anterior cingulate cortex, orbitofrontal cortex, and anterior insular cortex, and project directly to midbrain dopamine neurons." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) [j.cub.2021.10.015](DOI:10.1016/j.cub.2021.10.015) -### trophoblast `http://purl.obolibrary.org/obo/UBERON_0000088` -#### Removed -- [trophoblast](http://purl.obolibrary.org/obo/UBERON_0000088) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [striosomal D1 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030048) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "striosome D1-MSN" + - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation) + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) [j.cub.2021.10.015](DOI:10.1016/j.cub.2021.10.015) +- [striosomal D1 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030048) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "D1S" + - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation) -### trunk neural crest `http://purl.obolibrary.org/obo/UBERON_0003083` -#### Removed -- [trunk neural crest](http://purl.obolibrary.org/obo/UBERON_0003083) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) [j.cub.2021.10.015](DOI:10.1016/j.cub.2021.10.015) +#### Added +- [striosomal D1 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030048) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "In Rhesus macaques, both striosomal D1 and D2 medium spiny neuron (MSN) cell types have been noted to have enriched gene expression of the following: KCNT1, KHDRBS3, FAM163A, BACH2, and KCNIP1. Striosomal MSN activations have been noted to influence cognitive and emotional decision making and value-based learning. In contrast to matrix MSNs, striosomal MSNs receive input from limbic territories, including the anterior cingulate cortex, orbitofrontal cortex, and anterior insular cortex, and project directly to midbrain dopamine neurons." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/j.cub.2021.10.015" +- [striosomal D1 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030048) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A DRD1-expressing medium spiny neuron that is part of a striosome of dorsal striatum." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/j.cub.2021.10.015" -### tubotympanic recess lumen `http://purl.obolibrary.org/obo/UBERON_0005625` -#### Removed -- [tubotympanic recess lumen](http://purl.obolibrary.org/obo/UBERON_0005625) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [striosomal D1 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030048) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "striosome D1 medium spiny neuron" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/j.cub.2021.10.015" +- [striosomal D1 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030048) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "D1S" + - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation) + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/j.cub.2021.10.015" -### tumor necrosis factor receptor superfamily member 11A `http://purl.obolibrary.org/obo/PR_000001954` +- [striosomal D1 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030048) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "striosome D1-MSN" + - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation) -#### Added -- [tumor necrosis factor receptor superfamily member 11A](http://purl.obolibrary.org/obo/PR_000001954) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [tumor necrosis factor receptor superfamily member 11A (human)](http://purl.obolibrary.org/obo/PR_Q9Y6Q6) + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/j.cub.2021.10.015" -### tunica adventitia of artery `http://purl.obolibrary.org/obo/UBERON_0007240` +### striosomal D2 medium spiny neuron `http://purl.obolibrary.org/obo/CL_4030049` #### Removed -- [tunica adventitia of artery](http://purl.obolibrary.org/obo/UBERON_0007240) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [striosomal D2 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030049) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "D2S" + - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation) + + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) [j.cub.2021.10.015](DOI:10.1016/j.cub.2021.10.015) +- [striosomal D2 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030049) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "striosome D2-MSN" + - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation) + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) [j.cub.2021.10.015](DOI:10.1016/j.cub.2021.10.015) -### tunica fibrosa of eyeball `http://purl.obolibrary.org/obo/UBERON_0012430` -#### Removed -- [tunica fibrosa of eyeball](http://purl.obolibrary.org/obo/UBERON_0012430) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [striosomal D2 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030049) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "In Rhesus macaques, both striosomal D1 and D2 medium spiny neuron (MSN) cell types have been noted to have enriched gene expression of the following: KCNT1, KHDRBS3, FAM163A, BACH2, and KCNIP1. Striosomal MSN activations have been noted to influence cognitive and emotional decision making and value-based learning. In contrast to matrix MSNs, striosomal MSNs receive input from limbic territories, including the anterior cingulate cortex, orbitofrontal cortex, and anterior insular cortex, and project directly to midbrain dopamine neurons." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) [j.cub.2021.10.015](DOI:10.1016/j.cub.2021.10.015) +- [striosomal D2 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030049) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "D2-striosome" + - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation) + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) [j.cub.2021.10.015](DOI:10.1016/j.cub.2021.10.015) -### tunica intima `http://purl.obolibrary.org/obo/UBERON_0002523` -#### Removed -- [tunica intima](http://purl.obolibrary.org/obo/UBERON_0002523) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [striosomal D2 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030049) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "striosome D2 medium spiny neuron" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) [j.cub.2021.10.015](DOI:10.1016/j.cub.2021.10.015) +- [striosomal D2 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030049) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A DRD2-expressing medium spiny neuron that is part of a striosome of dorsal striatum." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) [j.cub.2021.10.015](DOI:10.1016/j.cub.2021.10.015) +#### Added +- [striosomal D2 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030049) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "striosome D2-MSN" + - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation) -### tunica media `http://purl.obolibrary.org/obo/UBERON_0002522` -#### Removed -- [tunica media](http://purl.obolibrary.org/obo/UBERON_0002522) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/j.cub.2021.10.015" +- [striosomal D2 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030049) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "striosome D2 medium spiny neuron" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/j.cub.2021.10.015" +- [striosomal D2 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030049) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "In Rhesus macaques, both striosomal D1 and D2 medium spiny neuron (MSN) cell types have been noted to have enriched gene expression of the following: KCNT1, KHDRBS3, FAM163A, BACH2, and KCNIP1. Striosomal MSN activations have been noted to influence cognitive and emotional decision making and value-based learning. In contrast to matrix MSNs, striosomal MSNs receive input from limbic territories, including the anterior cingulate cortex, orbitofrontal cortex, and anterior insular cortex, and project directly to midbrain dopamine neurons." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/j.cub.2021.10.015" -### type 1 spiral ganglion neuron `http://purl.obolibrary.org/obo/CL_4023115` -#### Removed -- [type 1 spiral ganglion neuron](http://purl.obolibrary.org/obo/CL_4023115) SubClassOf [neuron projection bundle](http://purl.obolibrary.org/obo/CARO_0001001) +- [striosomal D2 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030049) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "D2-striosome" + - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation) -#### Added -- [type 1 spiral ganglion neuron](http://purl.obolibrary.org/obo/CL_4023115) SubClassOf [neuron projection bundle](http://purl.obolibrary.org/obo/UBERON_0000122) + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/j.cub.2021.10.015" +- [striosomal D2 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030049) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "D2S" + - [has_synonym_type](http://www.geneontology.org/formats/oboInOwl#hasSynonymType) [abbreviation](http://purl.obolibrary.org/obo/cl#abbreviation) -### type 2 spiral ganglion neuron `http://purl.obolibrary.org/obo/CL_4023116` -#### Removed -- [type 2 spiral ganglion neuron](http://purl.obolibrary.org/obo/CL_4023116) SubClassOf [neuron projection bundle](http://purl.obolibrary.org/obo/CARO_0001001) + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/j.cub.2021.10.015" -#### Added -- [type 2 spiral ganglion neuron](http://purl.obolibrary.org/obo/CL_4023116) SubClassOf [neuron projection bundle](http://purl.obolibrary.org/obo/UBERON_0000122) +- [striosomal D2 medium spiny neuron](http://purl.obolibrary.org/obo/CL_4030049) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A DRD2-expressing medium spiny neuron that is part of a striosome of dorsal striatum." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "doi:10.1016/j.cub.2021.10.015" -### type II pneumocyte `http://purl.obolibrary.org/obo/CL_0002063` +### symbol `http://purl.obolibrary.org/obo/IAO_0000028` #### Removed -- [type II pneumocyte](http://purl.obolibrary.org/obo/CL_0002063) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [symbol](http://purl.obolibrary.org/obo/IAO_0000028) [IAO_0000112](http://purl.obolibrary.org/obo/IAO_0000112) "a stop sign"@en + +- [symbol](http://purl.obolibrary.org/obo/IAO_0000028) [IAO_0000119](http://purl.obolibrary.org/obo/IAO_0000119) "based on Oxford English Dictionary"@en + +- [symbol](http://purl.obolibrary.org/obo/IAO_0000028) [label](http://www.w3.org/2000/01/rdf-schema#label) "symbol"@en +- [symbol](http://purl.obolibrary.org/obo/IAO_0000028) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "An information content entity that is a mark(s) or character(s) used as a conventional representation of another entity."@en +- [symbol](http://purl.obolibrary.org/obo/IAO_0000028) [IAO_0000112](http://purl.obolibrary.org/obo/IAO_0000112) "a written proper name such as "OBI""@en -### tyrosine-protein kinase Mer `http://purl.obolibrary.org/obo/PR_000010329` +- [symbol](http://purl.obolibrary.org/obo/IAO_0000028) [IAO_0000117](http://purl.obolibrary.org/obo/IAO_0000117) "PERSON: James A. Overton"@en -#### Added -- [tyrosine-protein kinase Mer](http://purl.obolibrary.org/obo/PR_000010329) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [tyrosine-protein kinase Mer (human)](http://purl.obolibrary.org/obo/PR_Q12866) +- [symbol](http://purl.obolibrary.org/obo/IAO_0000028) [editor note](http://purl.obolibrary.org/obo/IAO_0000116) "2014-03-31: We would like to have a deeper analysis of 'mark' and 'sign' in the future (see https://github.com/information-artifact-ontology/IAO/issues/154)."@en +- [symbol](http://purl.obolibrary.org/obo/IAO_0000028) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "symbol"@en -### tyrosine-protein kinase receptor UFO `http://purl.obolibrary.org/obo/PR_000004528` +- [symbol](http://purl.obolibrary.org/obo/IAO_0000028) [editor note](http://purl.obolibrary.org/obo/IAO_0000116) "20091104, MC: this needs work and will most probably change"@en -#### Added -- [tyrosine-protein kinase receptor UFO](http://purl.obolibrary.org/obo/PR_000004528) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [tyrosine-protein kinase receptor UFO (human)](http://purl.obolibrary.org/obo/PR_P30530) +- [symbol](http://purl.obolibrary.org/obo/IAO_0000028) [IAO_0000117](http://purl.obolibrary.org/obo/IAO_0000117) "PERSON: Jonathan Rees"@en + +- [symbol](http://purl.obolibrary.org/obo/IAO_0000028) [IAO_0000114](http://purl.obolibrary.org/obo/IAO_0000114) [pending final vetting](http://purl.obolibrary.org/obo/IAO_0000125) + +- [symbol](http://purl.obolibrary.org/obo/IAO_0000028) [IAO_0000112](http://purl.obolibrary.org/obo/IAO_0000112) "a serial number such as "12324X""@en +- Class: [symbol](http://purl.obolibrary.org/obo/IAO_0000028) -### tyrosine-protein phosphatase non-receptor type substrate 1 `http://purl.obolibrary.org/obo/PR_000001968` +- [symbol](http://purl.obolibrary.org/obo/IAO_0000028) SubClassOf [information content entity](http://purl.obolibrary.org/obo/IAO_0000030) #### Added -- [tyrosine-protein phosphatase non-receptor type substrate 1](http://purl.obolibrary.org/obo/PR_000001968) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [tyrosine-protein phosphatase non-receptor type substrate 1 (human)](http://purl.obolibrary.org/obo/PR_P78324) +- [symbol](http://purl.obolibrary.org/obo/IAO_0000028) [label](http://www.w3.org/2000/01/rdf-schema#label) "symbol" -### umbilical cord `http://purl.obolibrary.org/obo/UBERON_0002331` +### syncytiotrophoblast cell `http://purl.obolibrary.org/obo/CL_0000525` #### Removed -- [umbilical cord](http://purl.obolibrary.org/obo/UBERON_0002331) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [syncytiotrophoblast cell](http://purl.obolibrary.org/obo/CL_0000525) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "syncytial trophoblast" +- [syncytiotrophoblast cell](http://purl.obolibrary.org/obo/CL_0000525) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "syntrophoblast" - -### uncurated `http://purl.obolibrary.org/obo/IAO_0000124` +- [syncytiotrophoblast cell](http://purl.obolibrary.org/obo/CL_0000525) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "plasmidotrophoblast" #### Added -- [uncurated](http://purl.obolibrary.org/obo/IAO_0000124) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Nothing done yet beyond assigning a unique class ID and proposing a preferred term."@en +- [syncytiotrophoblast cell](http://purl.obolibrary.org/obo/CL_0000525) [see also](http://www.w3.org/2000/01/rdf-schema#seeAlso) "https://github.com/obophenotype/cell-ontology/issues/2100" -- [uncurated](http://purl.obolibrary.org/obo/IAO_0000124) [label](http://www.w3.org/2000/01/rdf-schema#label) "uncurated"@en +- [syncytiotrophoblast cell](http://purl.obolibrary.org/obo/CL_0000525) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "syncytiotrophoblastic cell" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:21733368" -- [uncurated](http://purl.obolibrary.org/obo/IAO_0000124) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "uncurated"@en +- [syncytiotrophoblast cell](http://purl.obolibrary.org/obo/CL_0000525) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "plasmidotrophoblast cell" -- Individual: [uncurated](http://purl.obolibrary.org/obo/IAO_0000124) +- [syncytiotrophoblast cell](http://purl.obolibrary.org/obo/CL_0000525) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "syntrophoblast cell" +- [syncytiotrophoblast cell](http://purl.obolibrary.org/obo/CL_0000525) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "syncytial trophoblast cell" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:11787150" -### undifferentiated genital tubercle `http://purl.obolibrary.org/obo/UBERON_0005876` + +### telocyte `http://purl.obolibrary.org/obo/CL_0017004` #### Removed -- [undifferentiated genital tubercle](http://purl.obolibrary.org/obo/UBERON_0005876) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [telocyte](http://purl.obolibrary.org/obo/CL_0017004) SubClassOf [connective tissue cell](http://purl.obolibrary.org/obo/CL_0002320) and ([has part](http://purl.obolibrary.org/obo/BFO_0000051) some [telopode](http://purl.obolibrary.org/obo/GO_0120327)) + +#### Added +- [telocyte](http://purl.obolibrary.org/obo/CL_0017004) SubClassOf [has part](http://purl.obolibrary.org/obo/BFO_0000051) some [telopode](http://purl.obolibrary.org/obo/GO_0120327) +- [telocyte](http://purl.obolibrary.org/obo/CL_0017004) SubClassOf [connective tissue cell](http://purl.obolibrary.org/obo/CL_0002320) -### unipolar brush cell `http://purl.obolibrary.org/obo/CL_4023161` +### term imported `http://purl.obolibrary.org/obo/IAO_0000228` #### Removed -- [unipolar brush cell](http://purl.obolibrary.org/obo/CL_4023161) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [term imported](http://purl.obolibrary.org/obo/IAO_0000228) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "term imported"@en +- [term imported](http://purl.obolibrary.org/obo/IAO_0000228) [label](http://www.w3.org/2000/01/rdf-schema#label) "term imported"@en +- [term imported](http://purl.obolibrary.org/obo/IAO_0000228) [editor note](http://purl.obolibrary.org/obo/IAO_0000116) "This is to be used when the original term has been replaced by a term imported from an other ontology. An editor note should indicate what is the URI of the new term to use."@en -### universal `http://purl.obolibrary.org/obo/IAO_0000410` +- Individual: [term imported](http://purl.obolibrary.org/obo/IAO_0000228) -#### Added -- [universal](http://purl.obolibrary.org/obo/IAO_0000410) [IAO_0000117](http://purl.obolibrary.org/obo/IAO_0000117) "Alan Ruttenberg"@en -- [universal](http://purl.obolibrary.org/obo/IAO_0000410) [label](http://www.w3.org/2000/01/rdf-schema#label) "universal"@en -- [universal](http://purl.obolibrary.org/obo/IAO_0000410) [IAO_0000119](http://purl.obolibrary.org/obo/IAO_0000119) "A Formal Theory of Substances, Qualities, and Universals, http://ontology.buffalo.edu/bfo/SQU.pdf"@en +### term replaced by `http://purl.obolibrary.org/obo/IAO_0100001` +#### Removed +- [term replaced by](http://purl.obolibrary.org/obo/IAO_0100001) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "Add as annotation triples in the granting ontology"@en -- [universal](http://purl.obolibrary.org/obo/IAO_0000410) [editor note](http://purl.obolibrary.org/obo/IAO_0000116) "Hard to give a definition for. Intuitively a "natural kind" rather than a collection of any old things, which a class is able to be, formally. At the meta level, universals are defined as positives, are disjoint with their siblings, have single asserted parents."@en +- [term replaced by](http://purl.obolibrary.org/obo/IAO_0100001) [IAO_0000114](http://purl.obolibrary.org/obo/IAO_0000114) [pending final vetting](http://purl.obolibrary.org/obo/IAO_0000125) -- [universal](http://purl.obolibrary.org/obo/IAO_0000410) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "universal"@en +- [term replaced by](http://purl.obolibrary.org/obo/IAO_0100001) [IAO_0000117](http://purl.obolibrary.org/obo/IAO_0000117) "Person:Alan Ruttenberg"@en -- Individual: [universal](http://purl.obolibrary.org/obo/IAO_0000410) +- [term replaced by](http://purl.obolibrary.org/obo/IAO_0100001) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Use on obsolete terms, relating the term to another term that can be used as a substitute"@en +- [term replaced by](http://purl.obolibrary.org/obo/IAO_0100001) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "term replaced by"@en -### upper arm epithelium `http://purl.obolibrary.org/obo/UBERON_0005228` -#### Removed -- [upper arm epithelium](http://purl.obolibrary.org/obo/UBERON_0005228) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [term replaced by](http://purl.obolibrary.org/obo/IAO_0100001) [IAO_0000119](http://purl.obolibrary.org/obo/IAO_0000119) "Person:Alan Ruttenberg"@en + +- [term replaced by](http://purl.obolibrary.org/obo/IAO_0100001) [label](http://www.w3.org/2000/01/rdf-schema#label) "term replaced by"@en -### upper digestive tract `http://purl.obolibrary.org/obo/UBERON_0004908` +### term split `http://purl.obolibrary.org/obo/IAO_0000229` #### Removed -- [upper digestive tract](http://purl.obolibrary.org/obo/UBERON_0004908) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [term split](http://purl.obolibrary.org/obo/IAO_0000229) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "term split"@en +- [term split](http://purl.obolibrary.org/obo/IAO_0000229) [editor note](http://purl.obolibrary.org/obo/IAO_0000116) "This is to be used when a term has been split in two or more new terms. An editor note should indicate the reason for the split and indicate the URIs of the new terms created."@en +- [term split](http://purl.obolibrary.org/obo/IAO_0000229) [label](http://www.w3.org/2000/01/rdf-schema#label) "term split"@en -### upper jaw region `http://purl.obolibrary.org/obo/UBERON_0001709` -#### Removed -- [upper jaw region](http://purl.obolibrary.org/obo/UBERON_0001709) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000) +- Individual: [term split](http://purl.obolibrary.org/obo/IAO_0000229) -### upper leg epithelium `http://purl.obolibrary.org/obo/UBERON_0005225` +### term tracker item `http://purl.obolibrary.org/obo/IAO_0000233` #### Removed -- [upper leg epithelium](http://purl.obolibrary.org/obo/UBERON_0005225) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [term tracker item](http://purl.obolibrary.org/obo/IAO_0000233) [IAO_0000119](http://purl.obolibrary.org/obo/IAO_0000119) "Person: Jie Zheng, Chris Stoeckert, Alan Ruttenberg"@en + +- [term tracker item](http://purl.obolibrary.org/obo/IAO_0000233) [IAO_0000114](http://purl.obolibrary.org/obo/IAO_0000114) [pending final vetting](http://purl.obolibrary.org/obo/IAO_0000125) +- [term tracker item](http://purl.obolibrary.org/obo/IAO_0000233) [IAO_0000112](http://purl.obolibrary.org/obo/IAO_0000112) "the URI for an OBI Terms ticket at sourceforge, such as https://sourceforge.net/p/obi/obi-terms/772/"@en +- [term tracker item](http://purl.obolibrary.org/obo/IAO_0000233) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "term tracker item"@en -### upper lip `http://purl.obolibrary.org/obo/UBERON_0001834` -#### Removed -- [upper lip](http://purl.obolibrary.org/obo/UBERON_0001834) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [term tracker item](http://purl.obolibrary.org/obo/IAO_0000233) [comment](http://www.w3.org/2000/01/rdf-schema#comment) "The 'tracker item' can associate a tracker with a specific ontology term."@en +- [term tracker item](http://purl.obolibrary.org/obo/IAO_0000233) [IAO_0000117](http://purl.obolibrary.org/obo/IAO_0000117) "Person: Jie Zheng, Chris Stoeckert, Alan Ruttenberg"@en +- [term tracker item](http://purl.obolibrary.org/obo/IAO_0000233) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "An IRI or similar locator for a request or discussion of an ontology term."@en -### upper motor neuron `http://purl.obolibrary.org/obo/CL_0008048` -#### Removed -- [upper motor neuron](http://purl.obolibrary.org/obo/CL_0008048) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [term tracker item](http://purl.obolibrary.org/obo/IAO_0000233) [label](http://www.w3.org/2000/01/rdf-schema#label) "term tracker item"@en -### upper respiratory tract `http://purl.obolibrary.org/obo/UBERON_0001557` +### terminal bronchiole `http://purl.obolibrary.org/obo/UBERON_0002187` #### Removed -- [upper respiratory tract](http://purl.obolibrary.org/obo/UBERON_0001557) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) - +- [terminal bronchiole](http://purl.obolibrary.org/obo/UBERON_0002187) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "The last conducting structure of non-respiratory bronchioles; after this point, the airways have alveoli in their walls." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "MGI:cwg" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ISBN:0-397-51047-0" -### upper rhombic lip `http://purl.obolibrary.org/obo/UBERON_0009841` + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "MP:0002268" #### Added -- [upper rhombic lip](http://purl.obolibrary.org/obo/UBERON_0009841) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "uberon" +- [terminal bronchiole](http://purl.obolibrary.org/obo/UBERON_0002187) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A bronchiole that is part of a secondary pulmonary lobule and the last conducting structure of a non-respiratory bronchiole; after this point, the airways have alveoli in their walls." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:16543587" -- [upper rhombic lip](http://purl.obolibrary.org/obo/UBERON_0009841) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "TAO:0001442" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "MGI:cwg" -- [upper rhombic lip](http://purl.obolibrary.org/obo/UBERON_0009841) [label](http://www.w3.org/2000/01/rdf-schema#label) "upper rhombic lip" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ISBN:0-397-51047-0" -- [upper rhombic lip](http://purl.obolibrary.org/obo/UBERON_0009841) [id](http://www.geneontology.org/formats/oboInOwl#id) "UBERON:0009841" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "MP:0002268" -- [upper rhombic lip](http://purl.obolibrary.org/obo/UBERON_0009841) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ZFA:0001442" +- [terminal bronchiole](http://purl.obolibrary.org/obo/UBERON_0002187) SubClassOf [distally connected to](http://purl.obolibrary.org/obo/uberon/core#distally_connected_to) some [respiratory bronchiole](http://purl.obolibrary.org/obo/UBERON_0002188) -- [upper rhombic lip](http://purl.obolibrary.org/obo/UBERON_0009841) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Anterior-most region of dorsal hindbrain within rhombomere 1, adjacent the midbrain-hindbrain boundary." - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ZFIN:curator" +- [terminal bronchiole](http://purl.obolibrary.org/obo/UBERON_0002187) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [secondary pulmonary lobule](http://purl.obolibrary.org/obo/UBERON_0010369) -- [upper rhombic lip](http://purl.obolibrary.org/obo/UBERON_0009841) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "upper (rostral) rhombic lip" +- [terminal bronchiole](http://purl.obolibrary.org/obo/UBERON_0002187) SubClassOf [distally connected to](http://purl.obolibrary.org/obo/uberon/core#distally_connected_to) some [pulmonary acinus](http://purl.obolibrary.org/obo/UBERON_0008874) -- [upper rhombic lip](http://purl.obolibrary.org/obo/UBERON_0009841) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "presumptive cerebellum" - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ZFA:0001442" -- [upper rhombic lip](http://purl.obolibrary.org/obo/UBERON_0009841) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "rhombomere 01 cerebellum primordium" - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "EHDAA2:0000229" +### terminal bronchiole epithelium `http://purl.obolibrary.org/obo/UBERON_0001958` +#### Removed +- [terminal bronchiole epithelium](http://purl.obolibrary.org/obo/UBERON_0001958) SubClassOf [has part](http://purl.obolibrary.org/obo/BFO_0000051) some [club cell](http://purl.obolibrary.org/obo/CL_0000158) + - [source](http://www.geneontology.org/formats/oboInOwl#source) "FMA" -- [upper rhombic lip](http://purl.obolibrary.org/obo/UBERON_0009841) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "DHBA:10665" +#### Added +- [terminal bronchiole epithelium](http://purl.obolibrary.org/obo/UBERON_0001958) [contributor](http://purl.org/dc/terms/contributor) [0000-0001-6677-8489](https://orcid.org/0000-0001-6677-8489) -- [upper rhombic lip](http://purl.obolibrary.org/obo/UBERON_0009841) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "EHDAA2:0000229" -- [upper rhombic lip](http://purl.obolibrary.org/obo/UBERON_0009841) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "rostral rhombic lip" - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "DHB:URL" +### terms merged `http://purl.obolibrary.org/obo/IAO_0000227` +#### Removed +- [terms merged](http://purl.obolibrary.org/obo/IAO_0000227) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "terms merged"@en -- [upper rhombic lip](http://purl.obolibrary.org/obo/UBERON_0009841) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [pheno_slim](http://purl.obolibrary.org/obo/uberon/core#pheno_slim) +- [terms merged](http://purl.obolibrary.org/obo/IAO_0000227) [editor note](http://purl.obolibrary.org/obo/IAO_0000116) "An editor note should explain what were the merged terms and the reason for the merge."@en -- [upper rhombic lip](http://purl.obolibrary.org/obo/UBERON_0009841) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "cerebellar anlage" - - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "ZFA:0001442" +- [terms merged](http://purl.obolibrary.org/obo/IAO_0000227) [label](http://www.w3.org/2000/01/rdf-schema#label) "terms merged"@en -- Class: [upper rhombic lip](http://purl.obolibrary.org/obo/UBERON_0009841) +- Individual: [terms merged](http://purl.obolibrary.org/obo/IAO_0000227) -- [upper rhombic lip](http://purl.obolibrary.org/obo/UBERON_0009841) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [rhombic lip](http://purl.obolibrary.org/obo/UBERON_0006215) - - [source](http://www.geneontology.org/formats/oboInOwl#source) "ZFA" -- [upper rhombic lip](http://purl.obolibrary.org/obo/UBERON_0009841) SubClassOf [part_of](http://purl.obolibrary.org/obo/BFO_0000050) some [rhombomere 1](http://purl.obolibrary.org/obo/UBERON_0005499) - - [source](http://www.geneontology.org/formats/oboInOwl#source) "ZFA" -- [upper rhombic lip](http://purl.obolibrary.org/obo/UBERON_0009841) SubClassOf [adjacent to](http://purl.obolibrary.org/obo/RO_0002220) some [midbrain-hindbrain boundary](http://purl.obolibrary.org/obo/UBERON_0003052) - - [source](http://www.geneontology.org/formats/oboInOwl#source) "ZFA-def" +### title `http://purl.org/dc/terms/title` -- [upper rhombic lip](http://purl.obolibrary.org/obo/UBERON_0009841) SubClassOf [regional part of brain](http://purl.obolibrary.org/obo/UBERON_0002616) +#### Added +- AnnotationProperty: [title](http://purl.org/dc/terms/title) -### upper urinary tract `http://purl.obolibrary.org/obo/UBERON_0011143` +### to be replaced with external ontology term `http://purl.obolibrary.org/obo/IAO_0000423` #### Removed -- [upper urinary tract](http://purl.obolibrary.org/obo/UBERON_0011143) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) - +- [to be replaced with external ontology term](http://purl.obolibrary.org/obo/IAO_0000423) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Terms with this status should eventually replaced with a term from another ontology."@en +- [to be replaced with external ontology term](http://purl.obolibrary.org/obo/IAO_0000423) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "to be replaced with external ontology term"@en -### ureteric bud `http://purl.obolibrary.org/obo/UBERON_0000084` -#### Removed -- [ureteric bud](http://purl.obolibrary.org/obo/UBERON_0000084) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [to be replaced with external ontology term](http://purl.obolibrary.org/obo/IAO_0000423) [IAO_0000119](http://purl.obolibrary.org/obo/IAO_0000119) "group:OBI"@en +- [to be replaced with external ontology term](http://purl.obolibrary.org/obo/IAO_0000423) [IAO_0000117](http://purl.obolibrary.org/obo/IAO_0000117) "Alan Ruttenberg"@en +- [to be replaced with external ontology term](http://purl.obolibrary.org/obo/IAO_0000423) [label](http://www.w3.org/2000/01/rdf-schema#label) "to be replaced with external ontology term"@en -### uriniferous tubule `http://purl.obolibrary.org/obo/UBERON_0007684` -#### Removed -- [uriniferous tubule](http://purl.obolibrary.org/obo/UBERON_0007684) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- Individual: [to be replaced with external ontology term](http://purl.obolibrary.org/obo/IAO_0000423) -### urogenital sinus lumen `http://purl.obolibrary.org/obo/UBERON_0009844` +### trans-synaptic signalling via exosome `http://purl.obolibrary.org/obo/GO_0099157` #### Removed -- [urogenital sinus lumen](http://purl.obolibrary.org/obo/UBERON_0009844) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [trans-synaptic signalling via exosome](http://purl.obolibrary.org/obo/GO_0099157) [label](http://www.w3.org/2000/01/rdf-schema#label) "trans-synaptic signalling via exosome" + +#### Added +- [trans-synaptic signalling via exosome](http://purl.obolibrary.org/obo/GO_0099157) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "trans-synaptic signalling via exosome" +- [trans-synaptic signalling via exosome](http://purl.obolibrary.org/obo/GO_0099157) [label](http://www.w3.org/2000/01/rdf-schema#label) "trans-synaptic signaling via exosome" -### urokinase plasminogen activator surface receptor `http://purl.obolibrary.org/obo/PR_000001969` +### trophectodermal cellular morphogenesis `http://purl.obolibrary.org/obo/GO_0001831` +#### Removed +- [trophectodermal cellular morphogenesis](http://purl.obolibrary.org/obo/GO_0001831) SubClassOf [cell morphogenesis involved in differentiation](http://purl.obolibrary.org/obo/GO_0000904) #### Added -- [urokinase plasminogen activator surface receptor](http://purl.obolibrary.org/obo/PR_000001969) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [urokinase plasminogen activator surface receptor (human)](http://purl.obolibrary.org/obo/PR_Q03405) +- [trophectodermal cellular morphogenesis](http://purl.obolibrary.org/obo/GO_0001831) SubClassOf [cell morphogenesis](http://purl.obolibrary.org/obo/GO_0000902) + +### type EC enteroendocrine cell `http://purl.obolibrary.org/obo/CL_0000577` +#### Removed +- [type EC enteroendocrine cell](http://purl.obolibrary.org/obo/CL_0000577) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A subtype of enteroendocrine cells found in the gastrointestinal mucosa, particularly in the glands of pyloric antrum; duodenum; and ileum. These cell type secretes serotonin and some neurotransmitters including enkephalins and substance P. Their secretory granules stain readily with silver (argentaffin stain)." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "MESH:A03.492.766.440.250" -### uteroglobin `http://purl.obolibrary.org/obo/PR_000014505` + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:9505449" #### Added -- [uteroglobin](http://purl.obolibrary.org/obo/PR_000014505) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [uteroglobin (human)](http://purl.obolibrary.org/obo/PR_P11684) +- [type EC enteroendocrine cell](http://purl.obolibrary.org/obo/CL_0000577) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "A subtype of enteroendocrine cells found in the gastrointestinal mucosa, particularly in the glands of pyloric antrum; duodenum; and ileum. These cell type secretes serotonin and some neurotransmitters including enkephalins and substance P. Their secretory granules stain readily with silver (argentaffin stain)." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:9505449" + +- [type EC enteroendocrine cell](http://purl.obolibrary.org/obo/CL_0000577) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "MESH:D004759" -### uterus `http://purl.obolibrary.org/obo/UBERON_0000995` +### ubiquitin-like modifier activating enzyme activity `http://purl.obolibrary.org/obo/GO_0008641` #### Removed -- [uterus](http://purl.obolibrary.org/obo/UBERON_0000995) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [ubiquitin-like modifier activating enzyme activity](http://purl.obolibrary.org/obo/GO_0008641) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Catalysis of the activation of small proteins, such as ubiquitin or ubiquitin-like proteins, through the formation of an ATP-dependent high-energy thiolester bond." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:mah" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:jl" +- [ubiquitin-like modifier activating enzyme activity](http://purl.obolibrary.org/obo/GO_0008641) [label](http://www.w3.org/2000/01/rdf-schema#label) "ubiquitin-like modifier activating enzyme activity" -### uvea `http://purl.obolibrary.org/obo/UBERON_0001768` -#### Removed -- [uvea](http://purl.obolibrary.org/obo/UBERON_0001768) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [ubiquitin-like modifier activating enzyme activity](http://purl.obolibrary.org/obo/GO_0008641) [term tracker item](http://purl.obolibrary.org/obo/IAO_0000233) "https://github.com/geneontology/go-ontology/issues/14208"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI) +- [ubiquitin-like modifier activating enzyme activity](http://purl.obolibrary.org/obo/GO_0008641) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "small protein activating enzyme activity" +- [ubiquitin-like modifier activating enzyme activity](http://purl.obolibrary.org/obo/GO_0008641) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "molecular_function" -### vascular cord `http://purl.obolibrary.org/obo/UBERON_0006965` -#### Removed -- [vascular cord](http://purl.obolibrary.org/obo/UBERON_0006965) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [ubiquitin-like modifier activating enzyme activity](http://purl.obolibrary.org/obo/GO_0008641) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [goslim_pir](http://purl.obolibrary.org/obo/go#goslim_pir) +- [ubiquitin-like modifier activating enzyme activity](http://purl.obolibrary.org/obo/GO_0008641) [has_alternative_id](http://www.geneontology.org/formats/oboInOwl#hasAlternativeId) "GO:0008642" +- [ubiquitin-like modifier activating enzyme activity](http://purl.obolibrary.org/obo/GO_0008641) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0008641" -### vascular endothelial growth factor receptor 2 `http://purl.obolibrary.org/obo/PR_000002112` +- Class: [ubiquitin-like modifier activating enzyme activity](http://purl.obolibrary.org/obo/GO_0008641) -#### Added -- [vascular endothelial growth factor receptor 2](http://purl.obolibrary.org/obo/PR_000002112) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [vascular endothelial growth factor receptor 2 (human)](http://purl.obolibrary.org/obo/PR_P35968) +- [ubiquitin-like modifier activating enzyme activity](http://purl.obolibrary.org/obo/GO_0008641) SubClassOf [ATP-dependent activity](http://purl.obolibrary.org/obo/GO_0140657) +- [ubiquitin-like modifier activating enzyme activity](http://purl.obolibrary.org/obo/GO_0008641) SubClassOf [ligase activity, forming carbon-sulfur bonds](http://purl.obolibrary.org/obo/GO_0016877) -### vascular plexus `http://purl.obolibrary.org/obo/UBERON_0005629` -#### Removed -- [vascular plexus](http://purl.obolibrary.org/obo/UBERON_0005629) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [ubiquitin-like modifier activating enzyme activity](http://purl.obolibrary.org/obo/GO_0008641) SubClassOf [catalytic activity, acting on a protein](http://purl.obolibrary.org/obo/GO_0140096) -### vasculature of eye `http://purl.obolibrary.org/obo/UBERON_0002203` +### ubiquitin-like protein conjugating enzyme activity `http://purl.obolibrary.org/obo/GO_0061650` #### Removed -- [vasculature of eye](http://purl.obolibrary.org/obo/UBERON_0002203) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [ubiquitin-like protein conjugating enzyme activity](http://purl.obolibrary.org/obo/GO_0061650) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Isoenergetic transfer of a ubiquitin-like protein (ULP) from one protein to another via the reaction X-SCP + Y = Y-SCP + X, where both the X-SCP and Y-SCP linkages are thioester bonds between the C-terminal amino acid of SCP and a sulfhydryl side group of a cysteine residue." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dph" +- [ubiquitin-like protein conjugating enzyme activity](http://purl.obolibrary.org/obo/GO_0061650) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "small conjugating protein conjugating enzyme activity" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dph" +- [ubiquitin-like protein conjugating enzyme activity](http://purl.obolibrary.org/obo/GO_0061650) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0061650" -### venous system `http://purl.obolibrary.org/obo/UBERON_0004582` -#### Removed -- [venous system](http://purl.obolibrary.org/obo/UBERON_0004582) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [ubiquitin-like protein conjugating enzyme activity](http://purl.obolibrary.org/obo/GO_0061650) [label](http://www.w3.org/2000/01/rdf-schema#label) "ubiquitin-like protein conjugating enzyme activity" +- [ubiquitin-like protein conjugating enzyme activity](http://purl.obolibrary.org/obo/GO_0061650) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "E2" +- [ubiquitin-like protein conjugating enzyme activity](http://purl.obolibrary.org/obo/GO_0061650) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2014-11-06T13:15:27Z" -### vertebral column `http://purl.obolibrary.org/obo/UBERON_0001130` -#### Removed -- [vertebral column](http://purl.obolibrary.org/obo/UBERON_0001130) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- [ubiquitin-like protein conjugating enzyme activity](http://purl.obolibrary.org/obo/GO_0061650) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "molecular_function" +- [ubiquitin-like protein conjugating enzyme activity](http://purl.obolibrary.org/obo/GO_0061650) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "dph" +- Class: [ubiquitin-like protein conjugating enzyme activity](http://purl.obolibrary.org/obo/GO_0061650) -### vestibular afferent neuron `http://purl.obolibrary.org/obo/CL_4023112` -#### Removed -- [vestibular afferent neuron](http://purl.obolibrary.org/obo/CL_4023112) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [ubiquitin-like protein conjugating enzyme activity](http://purl.obolibrary.org/obo/GO_0061650) SubClassOf [ubiquitin-like protein transferase activity](http://purl.obolibrary.org/obo/GO_0019787) -### vestibulocochlear nerve `http://purl.obolibrary.org/obo/UBERON_0001648` +### ubiquitin-like protein ligase activity `http://purl.obolibrary.org/obo/GO_0061659` #### Removed -- [vestibulocochlear nerve](http://purl.obolibrary.org/obo/UBERON_0001648) SubClassOf [neuron projection bundle](http://purl.obolibrary.org/obo/CARO_0001001) +- [ubiquitin-like protein ligase activity](http://purl.obolibrary.org/obo/GO_0061659) [created_by](http://www.geneontology.org/formats/oboInOwl#created_by) "dph" +- [ubiquitin-like protein ligase activity](http://purl.obolibrary.org/obo/GO_0061659) [creation_date](http://www.geneontology.org/formats/oboInOwl#creation_date) "2014-11-06T13:46:23Z" +- [ubiquitin-like protein ligase activity](http://purl.obolibrary.org/obo/GO_0061659) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0061659" -### vimentin `http://purl.obolibrary.org/obo/PR_000017298` +- [ubiquitin-like protein ligase activity](http://purl.obolibrary.org/obo/GO_0061659) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "molecular_function" -#### Added -- [vimentin](http://purl.obolibrary.org/obo/PR_000017298) [crossSpeciesExactMatch](https://w3id.org/semapv/vocab/crossSpeciesExactMatch) [vimentin (human)](http://purl.obolibrary.org/obo/PR_P08670) +- [ubiquitin-like protein ligase activity](http://purl.obolibrary.org/obo/GO_0061659) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Catalysis of the transfer of a ubiquitin-like protein (ULP) to a substrate protein via the reaction X-ULP + S = X + S-ULP, where X is either an E2 or E3 enzyme, the X-ULP linkage is a thioester bond, and the S-ULP linkage is an isopeptide bond between the C-terminal glycine of ULP and the epsilon-amino group of lysine residues in the substrate." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dph" +- [ubiquitin-like protein ligase activity](http://purl.obolibrary.org/obo/GO_0061659) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "E3" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dph" -### vip GABAergic cortical interneuron `http://purl.obolibrary.org/obo/CL_4023016` +- [ubiquitin-like protein ligase activity](http://purl.obolibrary.org/obo/GO_0061659) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "small conjugating protein ligase activity" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dph" -#### Added -- [vip GABAergic cortical interneuron](http://purl.obolibrary.org/obo/CL_4023016) [symbol](http://purl.obolibrary.org/obo/IAO_0000028) "vip cortical interneuron" +- [ubiquitin-like protein ligase activity](http://purl.obolibrary.org/obo/GO_0061659) [label](http://www.w3.org/2000/01/rdf-schema#label) "ubiquitin-like protein ligase activity" +- Class: [ubiquitin-like protein ligase activity](http://purl.obolibrary.org/obo/GO_0061659) -### visceral pleura `http://purl.obolibrary.org/obo/UBERON_0002401` -#### Removed -- [visceral pleura](http://purl.obolibrary.org/obo/UBERON_0002401) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000) +- [ubiquitin-like protein ligase activity](http://purl.obolibrary.org/obo/GO_0061659) SubClassOf [ubiquitin-like protein transferase activity](http://purl.obolibrary.org/obo/GO_0019787) -### visceral serous pericardium `http://purl.obolibrary.org/obo/UBERON_0002425` +### ubiquitin-like protein transferase activity `http://purl.obolibrary.org/obo/GO_0019787` #### Removed -- [visceral serous pericardium](http://purl.obolibrary.org/obo/UBERON_0002425) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000) +- [ubiquitin-like protein transferase activity](http://purl.obolibrary.org/obo/GO_0019787) [has_alternative_id](http://www.geneontology.org/formats/oboInOwl#hasAlternativeId) "GO:0008639" +- [ubiquitin-like protein transferase activity](http://purl.obolibrary.org/obo/GO_0019787) [id](http://www.geneontology.org/formats/oboInOwl#id) "GO:0019787" +- [ubiquitin-like protein transferase activity](http://purl.obolibrary.org/obo/GO_0019787) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "ubiquitin-like conjugating enzyme activity" -### visceromotor neuron `http://purl.obolibrary.org/obo/CL_0005025` -#### Removed -- [visceromotor neuron](http://purl.obolibrary.org/obo/CL_0005025) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) - +- [ubiquitin-like protein transferase activity](http://purl.obolibrary.org/obo/GO_0019787) [has_related_synonym](http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym) "E3" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dph" +- [ubiquitin-like protein transferase activity](http://purl.obolibrary.org/obo/GO_0019787) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "small conjugating protein ligase activity" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dph" -### vomerine dentition `http://purl.obolibrary.org/obo/UBERON_0017615` -#### Removed -- [vomerine dentition](http://purl.obolibrary.org/obo/UBERON_0017615) SubClassOf [connected anatomical structure](http://purl.obolibrary.org/obo/CARO_0000003) +- [ubiquitin-like protein transferase activity](http://purl.obolibrary.org/obo/GO_0019787) [has_exact_synonym](http://www.geneontology.org/formats/oboInOwl#hasExactSynonym) "small conjugating protein transferase activity" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:dph" -#### Added -- [vomerine dentition](http://purl.obolibrary.org/obo/UBERON_0017615) SubClassOf [structure with developmental contribution from neural crest](http://purl.obolibrary.org/obo/UBERON_0010314) +- [ubiquitin-like protein transferase activity](http://purl.obolibrary.org/obo/GO_0019787) [has_alternative_id](http://www.geneontology.org/formats/oboInOwl#hasAlternativeId) "GO:0008640" +- [ubiquitin-like protein transferase activity](http://purl.obolibrary.org/obo/GO_0019787) [has_broad_synonym](http://www.geneontology.org/formats/oboInOwl#hasBroadSynonym) "E2" -### vomeronasal sensory neuron `http://purl.obolibrary.org/obo/CL_1001561` -#### Removed -- [vomeronasal sensory neuron](http://purl.obolibrary.org/obo/CL_1001561) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [ubiquitin-like protein transferase activity](http://purl.obolibrary.org/obo/GO_0019787) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-688137" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "RIP2 is K63 polyubiquitinated" +- [ubiquitin-like protein transferase activity](http://purl.obolibrary.org/obo/GO_0019787) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "small protein conjugating enzyme activity" +- [ubiquitin-like protein transferase activity](http://purl.obolibrary.org/obo/GO_0019787) [has_obo_namespace](http://www.geneontology.org/formats/oboInOwl#hasOBONamespace) "molecular_function" -### wall of heart `http://purl.obolibrary.org/obo/UBERON_0037144` -#### Removed -- [wall of heart](http://purl.obolibrary.org/obo/UBERON_0037144) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000) +- [ubiquitin-like protein transferase activity](http://purl.obolibrary.org/obo/GO_0019787) [term tracker item](http://purl.obolibrary.org/obo/IAO_0000233) "https://github.com/geneontology/go-ontology/issues/24697"^^[anyURI](http://www.w3.org/2001/XMLSchema#anyURI) +- [ubiquitin-like protein transferase activity](http://purl.obolibrary.org/obo/GO_0019787) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [goslim_pir](http://purl.obolibrary.org/obo/go#goslim_pir) +- [ubiquitin-like protein transferase activity](http://purl.obolibrary.org/obo/GO_0019787) [label](http://www.w3.org/2000/01/rdf-schema#label) "ubiquitin-like protein transferase activity" -### wall of ureter `http://purl.obolibrary.org/obo/UBERON_0009916` -#### Removed -- [wall of ureter](http://purl.obolibrary.org/obo/UBERON_0009916) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [ubiquitin-like protein transferase activity](http://purl.obolibrary.org/obo/GO_0019787) [in_subset](http://www.geneontology.org/formats/oboInOwl#inSubset) [goslim_drosophila](http://purl.obolibrary.org/obo/go#goslim_drosophila) +- [ubiquitin-like protein transferase activity](http://purl.obolibrary.org/obo/GO_0019787) [has_narrow_synonym](http://www.geneontology.org/formats/oboInOwl#hasNarrowSynonym) "ubiquitin-like-protein ligase activity" +- [ubiquitin-like protein transferase activity](http://purl.obolibrary.org/obo/GO_0019787) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Catalysis of the transfer of a ubiquitin-like from one protein to another via the reaction X-ULP + Y = Y-ULP + X, where both X-ULP and Y-ULP are covalent linkages. ULP represents a ubiquitin-like protein." + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:mah" -### white pulp of spleen `http://purl.obolibrary.org/obo/UBERON_0001959` -#### Removed -- [white pulp of spleen](http://purl.obolibrary.org/obo/UBERON_0001959) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:10806345" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "PMID:10884686" + - [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "GOC:rn" -### xanthophore cell `http://purl.obolibrary.org/obo/CL_0000430` -#### Removed -- [xanthophore cell](http://purl.obolibrary.org/obo/CL_0000430) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [ubiquitin-like protein transferase activity](http://purl.obolibrary.org/obo/GO_0019787) [database_cross_reference](http://www.geneontology.org/formats/oboInOwl#hasDbXref) "Reactome:R-HSA-5678490" + - [label](http://www.w3.org/2000/01/rdf-schema#label) "ATG16L1 complex transfers LC3 from ATG3 to PE" +- Class: [ubiquitin-like protein transferase activity](http://purl.obolibrary.org/obo/GO_0019787) +- [ubiquitin-like protein transferase activity](http://purl.obolibrary.org/obo/GO_0019787) SubClassOf [aminoacyltransferase activity](http://purl.obolibrary.org/obo/GO_0016755) -### yellow bone marrow `http://purl.obolibrary.org/obo/UBERON_0000332` -#### Removed -- [yellow bone marrow](http://purl.obolibrary.org/obo/UBERON_0000332) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [ubiquitin-like protein transferase activity](http://purl.obolibrary.org/obo/GO_0019787) SubClassOf [catalytic activity, acting on a protein](http://purl.obolibrary.org/obo/GO_0140096) -### yolk sac `http://purl.obolibrary.org/obo/UBERON_0001040` +### uncurated `http://purl.obolibrary.org/obo/IAO_0000124` #### Removed -- [yolk sac](http://purl.obolibrary.org/obo/UBERON_0001040) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [uncurated](http://purl.obolibrary.org/obo/IAO_0000124) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "uncurated"@en +- [uncurated](http://purl.obolibrary.org/obo/IAO_0000124) [definition](http://purl.obolibrary.org/obo/IAO_0000115) "Nothing done yet beyond assigning a unique class ID and proposing a preferred term."@en +- [uncurated](http://purl.obolibrary.org/obo/IAO_0000124) [label](http://www.w3.org/2000/01/rdf-schema#label) "uncurated"@en -### yolk sac hematopoietic stem cell `http://purl.obolibrary.org/obo/CL_0002354` -#### Removed -- [yolk sac hematopoietic stem cell](http://purl.obolibrary.org/obo/CL_0002354) SubClassOf [material anatomical entity](http://purl.obolibrary.org/obo/CARO_0000006) +- Individual: [uncurated](http://purl.obolibrary.org/obo/IAO_0000124) -### zeugopod `http://purl.obolibrary.org/obo/UBERON_0002471` +### universal `http://purl.obolibrary.org/obo/IAO_0000410` #### Removed -- [zeugopod](http://purl.obolibrary.org/obo/UBERON_0002471) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000) - +- [universal](http://purl.obolibrary.org/obo/IAO_0000410) [label](http://www.w3.org/2000/01/rdf-schema#label) "universal"@en +- [universal](http://purl.obolibrary.org/obo/IAO_0000410) [IAO_0000119](http://purl.obolibrary.org/obo/IAO_0000119) "A Formal Theory of Substances, Qualities, and Universals, http://ontology.buffalo.edu/bfo/SQU.pdf"@en -### zeugopodial skeleton `http://purl.obolibrary.org/obo/UBERON_0011584` -#### Removed -- [zeugopodial skeleton](http://purl.obolibrary.org/obo/UBERON_0011584) SubClassOf [multicellular anatomical structure](http://purl.obolibrary.org/obo/CARO_0010000) +- [universal](http://purl.obolibrary.org/obo/IAO_0000410) [IAO_0000111](http://purl.obolibrary.org/obo/IAO_0000111) "universal"@en +- [universal](http://purl.obolibrary.org/obo/IAO_0000410) [IAO_0000117](http://purl.obolibrary.org/obo/IAO_0000117) "Alan Ruttenberg"@en +- [universal](http://purl.obolibrary.org/obo/IAO_0000410) [editor note](http://purl.obolibrary.org/obo/IAO_0000116) "Hard to give a definition for. Intuitively a "natural kind" rather than a collection of any old things, which a class is able to be, formally. At the meta level, universals are defined as positives, are disjoint with their siblings, have single asserted parents."@en -### zona glomerulosa of adrenal gland `http://purl.obolibrary.org/obo/UBERON_0002053` -#### Removed -- [zona glomerulosa of adrenal gland](http://purl.obolibrary.org/obo/UBERON_0002053) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- Individual: [universal](http://purl.obolibrary.org/obo/IAO_0000410) -### zone of bone organ `http://purl.obolibrary.org/obo/UBERON_0005913` -#### Removed -- [zone of bone organ](http://purl.obolibrary.org/obo/UBERON_0005913) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +### vascular associated smooth muscle cell `http://purl.obolibrary.org/obo/CL_0000359` +#### Added +- [vascular associated smooth muscle cell](http://purl.obolibrary.org/obo/CL_0000359) SubClassOf [perivascular cell](http://purl.obolibrary.org/obo/CL_4033054) -### zone of skin `http://purl.obolibrary.org/obo/UBERON_0000014` +### wide field retinal amacrine cell `http://purl.obolibrary.org/obo/CL_0004253` #### Removed -- [zone of skin](http://purl.obolibrary.org/obo/UBERON_0000014) SubClassOf [anatomical entity](http://purl.obolibrary.org/obo/CARO_0000000) +- [wide field retinal amacrine cell](http://purl.obolibrary.org/obo/CL_0004253) SubClassOf [retina horizontal cell](http://purl.obolibrary.org/obo/CL_0000745) diff --git a/src/ontology/reports/cl-edit.owl-obo-report.tsv b/src/ontology/reports/cl-edit.owl-obo-report.tsv index 126bc9f39..b228e5a46 100644 --- a/src/ontology/reports/cl-edit.owl-obo-report.tsv +++ b/src/ontology/reports/cl-edit.owl-obo-report.tsv @@ -30,7 +30,6 @@ WARN missing_definition CL:0000146 IAO:0000115 WARN missing_definition CL:0000149 IAO:0000115 WARN missing_definition CL:0000154 IAO:0000115 WARN missing_definition CL:0000159 IAO:0000115 -WARN missing_definition CL:0000161 IAO:0000115 WARN missing_definition CL:0000167 IAO:0000115 WARN missing_definition CL:0000168 IAO:0000115 WARN missing_definition CL:0000172 IAO:0000115 @@ -189,7 +188,6 @@ WARN missing_definition CL:1000143 IAO:0000115 WARN missing_definition CL:1000182 IAO:0000115 WARN missing_definition CL:1000217 IAO:0000115 WARN missing_definition CL:1000222 IAO:0000115 -WARN missing_definition CL:1000223 IAO:0000115 WARN missing_definition CL:1000236 IAO:0000115 WARN missing_definition CL:1000239 IAO:0000115 WARN missing_definition CL:1000245 IAO:0000115 @@ -297,6 +295,7 @@ WARN missing_definition CL:4023057 IAO:0000115 WARN missing_definition CL:4030044 IAO:0000115 WARN missing_definition CL:4030045 IAO:0000115 WARN missing_definition CL:4030046 IAO:0000115 +WARN missing_definition IAO:0000028 IAO:0000115 WARN missing_definition IAO:0000115 IAO:0000115 WARN missing_definition IAO:0000424 IAO:0000115 WARN missing_definition IAO:0000700 IAO:0000115 @@ -449,6 +448,7 @@ INFO missing_superclass CL:0002673 rdfs:subClassOf INFO missing_superclass CL:0003001 rdfs:subClassOf INFO missing_superclass CL:0004246 rdfs:subClassOf INFO missing_superclass CL:0004247 rdfs:subClassOf +INFO missing_superclass CL:0004250 rdfs:subClassOf INFO missing_superclass CL:0005018 rdfs:subClassOf INFO missing_superclass CL:0005023 rdfs:subClassOf INFO missing_superclass CL:0008003 rdfs:subClassOf @@ -576,7 +576,6 @@ INFO missing_superclass CL:1000123 rdfs:subClassOf INFO missing_superclass CL:1000143 rdfs:subClassOf INFO missing_superclass CL:1000217 rdfs:subClassOf INFO missing_superclass CL:1000222 rdfs:subClassOf -INFO missing_superclass CL:1000223 rdfs:subClassOf INFO missing_superclass CL:1000236 rdfs:subClassOf INFO missing_superclass CL:1000239 rdfs:subClassOf INFO missing_superclass CL:1000245 rdfs:subClassOf @@ -715,7 +714,6 @@ INFO missing_superclass CL:4023068 rdfs:subClassOf INFO missing_superclass CL:4023069 rdfs:subClassOf INFO missing_superclass CL:4023070 rdfs:subClassOf INFO missing_superclass CL:4023072 rdfs:subClassOf -INFO missing_superclass CL:4023073 rdfs:subClassOf INFO missing_superclass CL:4023074 rdfs:subClassOf INFO missing_superclass CL:4023076 rdfs:subClassOf INFO missing_superclass CL:4023077 rdfs:subClassOf @@ -785,5 +783,10 @@ INFO missing_superclass CL:4033022 rdfs:subClassOf INFO missing_superclass CL:4033025 rdfs:subClassOf INFO missing_superclass CL:4033026 rdfs:subClassOf INFO missing_superclass CL:4033040 rdfs:subClassOf +INFO missing_superclass CL:4033046 rdfs:subClassOf +INFO missing_superclass CL:4033047 rdfs:subClassOf INFO missing_superclass CL:4033049 rdfs:subClassOf INFO missing_superclass CL:4033050 rdfs:subClassOf +INFO missing_superclass CL:4033051 rdfs:subClassOf +INFO missing_superclass CL:4033052 rdfs:subClassOf +INFO missing_superclass CL:4033054 rdfs:subClassOf diff --git a/src/ontology/subsets/blood_and_immune_upper_slim.json b/src/ontology/subsets/blood_and_immune_upper_slim.json index 916711a50..17ab82d0d 100644 --- a/src/ontology/subsets/blood_and_immune_upper_slim.json +++ b/src/ontology/subsets/blood_and_immune_upper_slim.json @@ -4,9 +4,9 @@ "meta" : { "basicPropertyValues" : [ { "pred" : "http://www.w3.org/2002/07/owl#versionInfo", - "val" : "2023-07-20" + "val" : "2023-08-24" } ], - "version" : "http://purl.obolibrary.org/obo/cl/releases/2023-07-20/subsets/blood_and_immune_upper_slim.owl" + "version" : "http://purl.obolibrary.org/obo/cl/releases/2023-08-24/subsets/blood_and_immune_upper_slim.owl" }, "nodes" : [ { "id" : "http://purl.obolibrary.org/obo/BFO_0000002", @@ -229,7 +229,7 @@ "pred" : "http://purl.obolibrary.org/obo/IAO_0000118", "val" : "preceded_by" }, { - "pred" : "http://purl.org/dc/elements/1.1/source", + "pred" : "http://purl.org/dc/terms/source", "val" : "http://www.obofoundry.org/ro/#OBO_REL:preceded_by" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", @@ -983,14 +983,15 @@ "comments" : [ "Markers differ between species, and two sets of markers have been described for mice. HSCs are reportedly CD34-positive, CD45-positive, CD48-negative, CD150-positive, CD133-positive, and CD244-negative." ], "subsets" : [ "http://purl.obolibrary.org/obo/cl#blood_and_immune_upper_slim", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ], "synonyms" : [ { - "pred" : "hasExactSynonym", - "val" : "HSC" - }, { "pred" : "hasExactSynonym", "val" : "blood forming stem cell" }, { "pred" : "hasExactSynonym", "val" : "hemopoietic stem cell" + }, { + "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation", + "pred" : "hasRelatedSynonym", + "val" : "HSC" }, { "pred" : "hasRelatedSynonym", "val" : "colony forming unit hematopoietic" @@ -1024,9 +1025,11 @@ }, "subsets" : [ "http://purl.obolibrary.org/obo/cl#blood_and_immune_upper_slim" ], "synonyms" : [ { + "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation", "pred" : "hasRelatedSynonym", "val" : "BFU-E" }, { + "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation", "pred" : "hasRelatedSynonym", "val" : "CFU-E" }, { @@ -1057,6 +1060,7 @@ }, "comments" : [ "Morphology: mononuclear cell, diameter 12-20 _M, non-granular, N/C ratio 3/1 - 4/1; markers: CD11b (shared with many other myeloid cells); location: Adult: bone marrow; fetal: liver, Yolk Sac; role or process: hematopoiesis, monocyte development; lineage: hematopoietic, myeloid." ], "synonyms" : [ { + "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation", "pred" : "hasRelatedSynonym", "val" : "CFU-M" }, { @@ -1113,20 +1117,23 @@ "comments" : [ "This cell type is intended to be compatible with any vertebrate common myeloid progenitor. For mammalian CMP known to be CD34-positive, please use the term 'common myeloid progenitor, CD34-positive' (CL_0001059)." ], "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ], "synonyms" : [ { - "pred" : "hasExactSynonym", - "val" : "CMP", - "xrefs" : [ "ISBN:0878932437" ] - }, { "pred" : "hasExactSynonym", "val" : "common myeloid precursor" }, { + "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation", "pred" : "hasRelatedSynonym", "val" : "CFU-GEMM", "xrefs" : [ "ISBN:0878932437" ] }, { + "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation", "pred" : "hasRelatedSynonym", "val" : "CFU-S", "xrefs" : [ "ISBN:0878932437" ] + }, { + "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation", + "pred" : "hasRelatedSynonym", + "val" : "CMP", + "xrefs" : [ "ISBN:0878932437" ] }, { "pred" : "hasRelatedSynonym", "val" : "colony forming unit granulocyte, erythrocyte, macrophage, and megakaryocyte", @@ -1202,9 +1209,6 @@ "comments" : [ "CLP are CD7-positive, CD10-positive, CD19-negative, CD34-positive, CD45RA-positive, CD79a-negative, CD127-positive, AA4.1-positive, RAG-negative, Sca-1-low, sIgM-negative, sIgD-negative, TdT-negative, Vpre-B-negative, and pre-BCR-negative. Expression of transcription factors include E2A-positive, EBF-positive, Ikaros-negative, PU.1-negative, and Pax5-negative." ], "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ], "synonyms" : [ { - "pred" : "hasExactSynonym", - "val" : "CLP" - }, { "pred" : "hasExactSynonym", "val" : "common lymphocyte precursor" }, { @@ -1214,6 +1218,11 @@ "pred" : "hasExactSynonym", "val" : "common lymphoid precursor" }, { + "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation", + "pred" : "hasRelatedSynonym", + "val" : "CLP" + }, { + "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation", "pred" : "hasRelatedSynonym", "val" : "ELP" }, { @@ -1351,6 +1360,9 @@ "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/RO_0002175", "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + }, { + "pred" : "http://xmlns.com/foaf/0.1/depicted_by", + "val" : "https://www.swissbiopics.org/api/image/Epithelial_cells.svg" } ] } }, { @@ -1598,9 +1610,6 @@ }, "comments" : [ "Many but not all mesenchymal cells derive from the mesoderm. MSCs are reportedly CD3-negative, CD4-negative, CD5-negative, CD8-negative, CD11a-negative, CD11b-negative, CD14-negative, CD19-negative, CD29-positive, CD31-negative, CD34-negative, CD38-negative, CD40-negative, CD44-positive, CD45-negative, CD49-positive, CD54-positive, CD66b-negative, CD79a-negative, CD80-negative, CD102-positive, CD106-positive, CD117-positive, CD121a-positive, CD121b-positive, CD123-positive, CD124-positive, CD133-negative, CD146-positive, CD166-positive, CD271-positive, B220-negative, Gr1-negative, MHCI-positive, MHCII-negative, SSEA4-negative, sca1-positive, Ter119-negative, and glycophorin A-negative. Cultured MSCs are capable of producing stem cell factor, IL7, IL8, IL11, TGF-beta, cofilin, galectin-1, laminin-receptor 1, cyclophilin A, and MMP-2." ], "synonyms" : [ { - "pred" : "hasNarrowSynonym", - "val" : "BMSC" - }, { "pred" : "hasNarrowSynonym", "val" : "bone marrow stromal cells" }, { @@ -1611,9 +1620,15 @@ "val" : "marrow stromal cells", "xrefs" : [ "PMID:11378515" ] }, { + "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation", + "pred" : "hasRelatedSynonym", + "val" : "BMSC" + }, { + "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation", "pred" : "hasRelatedSynonym", "val" : "CFU-F" }, { + "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation", "pred" : "hasRelatedSynonym", "val" : "MSC", "xrefs" : [ "PMID:11378515" ] @@ -1665,7 +1680,8 @@ "comments" : [ "Note change of name; nearly all somatic cells can present antigens to T cells via MHC Class I complexes leading to effector responses, but professional antigen presenting cells constitutively express MHC Class II as well as costimulatory molecules, and thus can initiate immune responses via T cells." ], "subsets" : [ "http://purl.obolibrary.org/obo/cl#blood_and_immune_upper_slim" ], "synonyms" : [ { - "pred" : "hasBroadSynonym", + "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation", + "pred" : "hasRelatedSynonym", "val" : "APC" } ] } @@ -1727,6 +1743,10 @@ "val" : "FMA:67328" }, { "val" : "WBbt:0003675" + } ], + "basicPropertyValues" : [ { + "pred" : "http://xmlns.com/foaf/0.1/depicted_by", + "val" : "https://www.swissbiopics.org/api/image/Muscle_cells.svg" } ] } }, { @@ -2056,7 +2076,7 @@ "meta" : { "definition" : { "val" : "A cell derived from the specialized ectoderm flanking each side of the embryonic neural plate, which after the closure of the neural tube, forms masses of cells that migrate out from the dorsal aspect of the neural tube to spread throughout the body.", - "xrefs" : [ "MESH:A16.254.600" ] + "xrefs" : [ "doi:10.1016/j.stem.2015.02.017" ] }, "xrefs" : [ { "val" : "FMA:86667" @@ -2216,6 +2236,9 @@ "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/RO_0002175", "val" : "http://purl.obolibrary.org/obo/NCBITaxon_9606" + }, { + "pred" : "http://xmlns.com/foaf/0.1/depicted_by", + "val" : "https://www.swissbiopics.org/api/image/Neuron_cells.svg" } ] } }, { @@ -2252,7 +2275,7 @@ "meta" : { "definition" : { "val" : "An immature, nucleated erythrocyte occupying the stage of erythropoeisis that follows formation of erythroid progenitor cells. This cell is CD71-positive, has both a nucleus and a nucleolus, and lacks hematopoeitic lineage markers.", - "xrefs" : [ "ISBN:0721601464", "MESH:A11.118.290.350.200", "PMID:1638021" ] + "xrefs" : [ "ISBN:0721601464", "PMID:1638021" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/cl#blood_and_immune_upper_slim" ], "synonyms" : [ { @@ -2279,6 +2302,10 @@ "synonyms" : [ { "pred" : "hasExactSynonym", "val" : "metazoan cell" + } ], + "basicPropertyValues" : [ { + "pred" : "http://xmlns.com/foaf/0.1/depicted_by", + "val" : "https://www.swissbiopics.org/api/image/Animal_cells.svg" } ] } }, { @@ -2490,14 +2517,6 @@ "pred" : "hasBroadSynonym", "val" : "CFU-C , Colony forming unit in culture", "xrefs" : [ "http://www.copewithcytokines.de" ] - }, { - "pred" : "hasExactSynonym", - "val" : "CFU-GM", - "xrefs" : [ "ISBN:0721601464", "PMCID:PMC2213186", "PMCID:PMC548021" ] - }, { - "pred" : "hasExactSynonym", - "val" : "GMP", - "xrefs" : [ "ISBN:0721601464", "PMCID:PMC2213186", "PMCID:PMC548021" ] }, { "pred" : "hasExactSynonym", "val" : "colony forming unit granulocyte macrophage", @@ -2512,6 +2531,16 @@ }, { "pred" : "hasExactSynonym", "val" : "granulocyte/monocyte progenitor" + }, { + "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation", + "pred" : "hasRelatedSynonym", + "val" : "CFU-GM", + "xrefs" : [ "ISBN:0721601464", "PMCID:PMC2213186", "PMCID:PMC548021" ] + }, { + "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation", + "pred" : "hasRelatedSynonym", + "val" : "GMP", + "xrefs" : [ "ISBN:0721601464", "PMCID:PMC2213186", "PMCID:PMC548021" ] } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/RO_0002175", @@ -3128,6 +3157,7 @@ "pred" : "hasExactSynonym", "val" : "gammadelta T cell" }, { + "synonymType" : "http://purl.obolibrary.org/obo/cl#abbreviation", "pred" : "hasRelatedSynonym", "val" : "gd T cell" } ], @@ -8303,7 +8333,8 @@ "val" : "Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538).", "xrefs" : [ "GOC:mah", "GOC:mtg_apoptosis", "PMID:25236395" ] }, - "comments" : [ "This term should not be used for direct annotation. The only exception should be when experimental data (e.g., staining with trypan blue or propidium iodide) show that cell death has occurred, but fail to provide details on death modality (accidental versus programmed). When information is provided on the cell death mechanism, annotations should be made to the appropriate descendant of 'cell death' (such as, but not limited to, GO:0097300 'programmed necrotic cell death' or GO:0006915 'apoptotic process'). Also, if experimental data suggest that a gene product influences cell death indirectly, rather than being involved in the death process directly, consider annotating to a 'regulation' term." ], + "comments" : [ "This term should not be used for direct annotation, it is currently kept in GO as a placeholder for describing cell death phenotypes in uPHENO. When information is provided on a programmed cell death mechanism, annotations should be made to the appropriate descendant of 'cell death' (such as, but not limited to, GO:0097300 'programmed necrotic cell death' or GO:0006915 'apoptotic process'). Unintentional cell death, i.e. cell death caused by injury, ageing, or cell phenotypes observed as a result of a pathological mutation in an essential gene should NOT be annotated using GO terms." ], + "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ], "synonyms" : [ { "pred" : "hasRelatedSynonym", "val" : "accidental cell death" @@ -8312,6 +8343,32 @@ "val" : "necrosis" } ], "basicPropertyValues" : [ { + "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", + "val" : "https://github.com/geneontology/go-ontology/issues/24680" + }, { + "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", + "val" : "biological_process" + } ] + } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0008283", + "lbl" : "cell population proliferation", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The multiplication or reproduction of cells, resulting in the expansion of a cell population.", + "xrefs" : [ "GOC:mah", "GOC:mb" ] + }, + "comments" : [ "This term was moved out from being a child of 'cellular process' because it is a cell population-level process, and cellular processes are restricted to those processes that involve individual cells. Also note that this term is intended to be used for the proliferation of cells within a multicellular organism, not for the expansion of a population of single-celled organisms." ], + "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_agr", "http://purl.obolibrary.org/obo/go#goslim_chembl", "http://purl.obolibrary.org/obo/go#goslim_drosophila", "http://purl.obolibrary.org/obo/go#goslim_flybase_ribbon", "http://purl.obolibrary.org/obo/go#goslim_mouse", "http://purl.obolibrary.org/obo/go#goslim_pir" ], + "synonyms" : [ { + "pred" : "hasRelatedSynonym", + "val" : "cell proliferation" + } ], + "basicPropertyValues" : [ { + "pred" : "http://purl.obolibrary.org/obo/RO_0002161", + "val" : "http://purl.obolibrary.org/obo/NCBITaxon_4751" + }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" } ] @@ -8394,7 +8451,10 @@ } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", - "val" : "http://amigo.geneontology.org/amigo/term/GO:0070589" + "val" : "https://github.com/geneontology/go-ontology/issues/15249" + }, { + "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", + "val" : "https://github.com/geneontology/go-ontology/issues/25418" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId", "val" : "GO:0043284" @@ -8672,7 +8732,7 @@ "type" : "CLASS", "meta" : { "definition" : { - "val" : "The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, translation and maturation for protein-coding genes.", + "val" : "The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, as well as translation and maturation for protein-coding genes.", "xrefs" : [ "GOC:txnOH-2018", "PMID:25934543", "PMID:31580950" ] }, "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_flybase_ribbon" ], @@ -8682,6 +8742,9 @@ "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", "val" : "https://github.com/geneontology/go-ontology/issues/22557" + }, { + "pred" : "http://purl.obolibrary.org/obo/IAO_0000233", + "val" : "https://github.com/geneontology/go-ontology/issues/25419" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "biological_process" @@ -11795,6 +11858,33 @@ "val" : "biological_process" } ] } + }, { + "id" : "http://purl.obolibrary.org/obo/GO_0044249", + "lbl" : "cellular biosynthetic process", + "type" : "CLASS", + "meta" : { + "definition" : { + "val" : "The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.", + "xrefs" : [ "GOC:jl" ] + }, + "synonyms" : [ { + "pred" : "hasExactSynonym", + "val" : "cellular anabolism" + }, { + "pred" : "hasExactSynonym", + "val" : "cellular biosynthesis" + }, { + "pred" : "hasExactSynonym", + "val" : "cellular formation" + }, { + "pred" : "hasExactSynonym", + "val" : "cellular synthesis" + } ], + "basicPropertyValues" : [ { + "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", + "val" : "biological_process" + } ] + } }, { "id" : "http://purl.obolibrary.org/obo/GO_0044419", "lbl" : "biological process involved in interspecies interaction between organisms", @@ -14938,83 +15028,22 @@ } ] } }, { - "id" : "http://purl.obolibrary.org/obo/IAO_0000002", - "lbl" : "example to be eventually removed", - "type" : "INDIVIDUAL", - "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/IAO_0000111", - "val" : "example to be eventually removed" - } ] - } - }, { - "id" : "http://purl.obolibrary.org/obo/IAO_0000103", - "lbl" : "failed exploratory term", - "type" : "INDIVIDUAL", - "meta" : { - "definition" : { - "val" : "The term was used in an attempt to structure part of the ontology but in retrospect failed to do a good job" - }, - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/IAO_0000111", - "val" : "failed exploratory term" - }, { - "pred" : "http://purl.obolibrary.org/obo/IAO_0000117", - "val" : "Person:Alan Ruttenberg" - } ] - } + "id" : "http://purl.obolibrary.org/obo/IAO_0000028", + "lbl" : "symbol", + "type" : "PROPERTY" }, { "id" : "http://purl.obolibrary.org/obo/IAO_0000115", "lbl" : "definition", - "type" : "PROPERTY", - "meta" : { - "definition" : { - "val" : "The official definition, explaining the meaning of a class or property. Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions." - }, - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/IAO_0000111", - "val" : "definition" - }, { - "pred" : "http://purl.obolibrary.org/obo/IAO_0000114", - "val" : "http://purl.obolibrary.org/obo/IAO_0000122" - }, { - "pred" : "http://purl.obolibrary.org/obo/IAO_0000116", - "val" : "2012-04-05: \nBarry Smith\n\nThe official OBI definition, explaining the meaning of a class or property: 'Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions' is terrible.\n\nCan you fix to something like:\n\nA statement of necessary and sufficient conditions explaining the meaning of an expression referring to a class or property.\n\nAlan Ruttenberg\n\nYour proposed definition is a reasonable candidate, except that it is very common that necessary and sufficient conditions are not given. Mostly they are necessary, occasionally they are necessary and sufficient or just sufficient. Often they use terms that are not themselves defined and so they effectively can't be evaluated by those criteria. \n\nOn the specifics of the proposed definition:\n\nWe don't have definitions of 'meaning' or 'expression' or 'property'. For 'reference' in the intended sense I think we use the term 'denotation'. For 'expression', I think we you mean symbol, or identifier. For 'meaning' it differs for class and property. For class we want documentation that let's the intended reader determine whether an entity is instance of the class, or not. For property we want documentation that let's the intended reader determine, given a pair of potential relata, whether the assertion that the relation holds is true. The 'intended reader' part suggests that we also specify who, we expect, would be able to understand the definition, and also generalizes over human and computer reader to include textual and logical definition. \n\nPersonally, I am more comfortable weakening definition to documentation, with instructions as to what is desirable. \n\nWe also have the outstanding issue of how to aim different definitions to different audiences. A clinical audience reading chebi wants a different sort of definition documentation/definition from a chemistry trained audience, and similarly there is a need for a definition that is adequate for an ontologist to work with. " - }, { - "pred" : "http://purl.obolibrary.org/obo/IAO_0000117", - "val" : "PERSON:Daniel Schober" - }, { - "pred" : "http://purl.obolibrary.org/obo/IAO_0000119", - "val" : "GROUP:OBI:" - }, { - "pred" : "http://www.w3.org/2000/01/rdf-schema#isDefinedBy", - "val" : "http://purl.obolibrary.org/obo/iao.owl" - } ] - } + "type" : "PROPERTY" }, { "id" : "http://purl.obolibrary.org/obo/IAO_0000116", "lbl" : "editor note", "type" : "PROPERTY", "meta" : { - "definition" : { - "val" : "An administrative note intended for its editor. It may not be included in the publication version of the ontology, so it should contain nothing necessary for end users to understand the ontology." - }, "xrefs" : [ { "val" : "IAO:0000116" } ], "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/IAO_0000111", - "val" : "editor note" - }, { - "pred" : "http://purl.obolibrary.org/obo/IAO_0000114", - "val" : "http://purl.obolibrary.org/obo/IAO_0000122" - }, { - "pred" : "http://purl.obolibrary.org/obo/IAO_0000117", - "val" : "PERSON:Daniel Schober" - }, { - "pred" : "http://purl.obolibrary.org/obo/IAO_0000119", - "val" : "GROUP:OBI:" - }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "uberon" }, { @@ -15023,180 +15052,6 @@ }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#shorthand", "val" : "editor_note" - }, { - "pred" : "http://www.w3.org/2000/01/rdf-schema#isDefinedBy", - "val" : "http://purl.obolibrary.org/obo/iao.owl" - } ] - } - }, { - "id" : "http://purl.obolibrary.org/obo/IAO_0000120", - "lbl" : "metadata complete", - "type" : "INDIVIDUAL", - "meta" : { - "definition" : { - "val" : "Class has all its metadata, but is either not guaranteed to be in its final location in the asserted IS_A hierarchy or refers to another class that is not complete." - }, - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/IAO_0000111", - "val" : "metadata complete" - } ] - } - }, { - "id" : "http://purl.obolibrary.org/obo/IAO_0000121", - "lbl" : "organizational term", - "type" : "INDIVIDUAL", - "meta" : { - "definition" : { - "val" : "Term created to ease viewing/sort terms for development purpose, and will not be included in a release" - }, - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/IAO_0000111", - "val" : "organizational term" - } ] - } - }, { - "id" : "http://purl.obolibrary.org/obo/IAO_0000122", - "lbl" : "ready for release", - "type" : "INDIVIDUAL", - "meta" : { - "definition" : { - "val" : "Class has undergone final review, is ready for use, and will be included in the next release. Any class lacking \"ready_for_release\" should be considered likely to change place in hierarchy, have its definition refined, or be obsoleted in the next release. Those classes deemed \"ready_for_release\" will also derived from a chain of ancestor classes that are also \"ready_for_release.\"" - }, - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/IAO_0000111", - "val" : "ready for release" - } ] - } - }, { - "id" : "http://purl.obolibrary.org/obo/IAO_0000123", - "lbl" : "metadata incomplete", - "type" : "INDIVIDUAL", - "meta" : { - "definition" : { - "val" : "Class is being worked on; however, the metadata (including definition) are not complete or sufficiently clear to the branch editors." - }, - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/IAO_0000111", - "val" : "metadata incomplete" - } ] - } - }, { - "id" : "http://purl.obolibrary.org/obo/IAO_0000124", - "lbl" : "uncurated", - "type" : "INDIVIDUAL", - "meta" : { - "definition" : { - "val" : "Nothing done yet beyond assigning a unique class ID and proposing a preferred term." - }, - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/IAO_0000111", - "val" : "uncurated" - } ] - } - }, { - "id" : "http://purl.obolibrary.org/obo/IAO_0000125", - "lbl" : "pending final vetting", - "type" : "INDIVIDUAL", - "meta" : { - "definition" : { - "val" : "All definitions, placement in the asserted IS_A hierarchy and required minimal metadata are complete. The class is awaiting a final review by someone other than the term editor." - }, - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/IAO_0000111", - "val" : "pending final vetting" - } ] - } - }, { - "id" : "http://purl.obolibrary.org/obo/IAO_0000136", - "lbl" : "is about", - "type" : "PROPERTY", - "meta" : { - "definition" : { - "val" : "A (currently) primitive relation that relates an information artifact to an entity." - }, - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/IAO_0000112", - "val" : "This document is about information artifacts and their representations" - }, { - "pred" : "http://purl.obolibrary.org/obo/IAO_0000114", - "val" : "http://purl.obolibrary.org/obo/IAO_0000125" - }, { - "pred" : "http://purl.obolibrary.org/obo/IAO_0000116", - "val" : "7/6/2009 Alan Ruttenberg. Following discussion with Jonathan Rees, and introduction of \"mentions\" relation. Weaken the is_about relationship to be primitive. \n\nWe will try to build it back up by elaborating the various subproperties that are more precisely defined.\n\nSome currently missing phenomena that should be considered \"about\" are predications - \"The only person who knows the answer is sitting beside me\" , Allegory, Satire, and other literary forms that can be topical without explicitly mentioning the topic." - }, { - "pred" : "http://purl.obolibrary.org/obo/IAO_0000117", - "val" : "person:Alan Ruttenberg" - }, { - "pred" : "http://purl.obolibrary.org/obo/IAO_0000119", - "val" : "Smith, Ceusters, Ruttenberg, 2000 years of philosophy" - } ] - } - }, { - "id" : "http://purl.obolibrary.org/obo/IAO_0000226", - "lbl" : "placeholder removed", - "type" : "INDIVIDUAL", - "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/IAO_0000111", - "val" : "placeholder removed" - } ] - } - }, { - "id" : "http://purl.obolibrary.org/obo/IAO_0000227", - "lbl" : "terms merged", - "type" : "INDIVIDUAL", - "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/IAO_0000111", - "val" : "terms merged" - }, { - "pred" : "http://purl.obolibrary.org/obo/IAO_0000116", - "val" : "An editor note should explain what were the merged terms and the reason for the merge." - } ] - } - }, { - "id" : "http://purl.obolibrary.org/obo/IAO_0000228", - "lbl" : "term imported", - "type" : "INDIVIDUAL", - "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/IAO_0000111", - "val" : "term imported" - }, { - "pred" : "http://purl.obolibrary.org/obo/IAO_0000116", - "val" : "This is to be used when the original term has been replaced by a term imported from an other ontology. An editor note should indicate what is the URI of the new term to use." - } ] - } - }, { - "id" : "http://purl.obolibrary.org/obo/IAO_0000229", - "lbl" : "term split", - "type" : "INDIVIDUAL", - "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/IAO_0000111", - "val" : "term split" - }, { - "pred" : "http://purl.obolibrary.org/obo/IAO_0000116", - "val" : "This is to be used when a term has been split in two or more new terms. An editor note should indicate the reason for the split and indicate the URIs of the new terms created." - } ] - } - }, { - "id" : "http://purl.obolibrary.org/obo/IAO_0000231", - "lbl" : "has obsolescence reason", - "type" : "PROPERTY", - "meta" : { - "definition" : { - "val" : "Relates an annotation property to an obsolescence reason. The values of obsolescence reasons come from a list of predefined terms, instances of the class obsolescence reason specification." - }, - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/IAO_0000111", - "val" : "has obsolescence reason" - }, { - "pred" : "http://purl.obolibrary.org/obo/IAO_0000117", - "val" : "PERSON:Alan Ruttenberg" - }, { - "pred" : "http://purl.obolibrary.org/obo/IAO_0000117", - "val" : "PERSON:Melanie Courtot" } ] } }, { @@ -15204,29 +15059,10 @@ "lbl" : "term tracker item", "type" : "PROPERTY", "meta" : { - "definition" : { - "val" : "An IRI or similar locator for a request or discussion of an ontology term." - }, - "comments" : [ "The 'tracker item' can associate a tracker with a specific ontology term." ], "xrefs" : [ { "val" : "IAO:0000233" } ], "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/IAO_0000111", - "val" : "term tracker item" - }, { - "pred" : "http://purl.obolibrary.org/obo/IAO_0000112", - "val" : "the URI for an OBI Terms ticket at sourceforge, such as https://sourceforge.net/p/obi/obi-terms/772/" - }, { - "pred" : "http://purl.obolibrary.org/obo/IAO_0000114", - "val" : "http://purl.obolibrary.org/obo/IAO_0000125" - }, { - "pred" : "http://purl.obolibrary.org/obo/IAO_0000117", - "val" : "Person: Jie Zheng, Chris Stoeckert, Alan Ruttenberg" - }, { - "pred" : "http://purl.obolibrary.org/obo/IAO_0000119", - "val" : "Person: Jie Zheng, Chris Stoeckert, Alan Ruttenberg" - }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "external" }, { @@ -15243,140 +15079,27 @@ "val" : "term_tracker_item" } ] } - }, { - "id" : "http://purl.obolibrary.org/obo/IAO_0000410", - "lbl" : "universal", - "type" : "INDIVIDUAL", - "meta" : { - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/IAO_0000111", - "val" : "universal" - }, { - "pred" : "http://purl.obolibrary.org/obo/IAO_0000116", - "val" : "Hard to give a definition for. Intuitively a \"natural kind\" rather than a collection of any old things, which a class is able to be, formally. At the meta level, universals are defined as positives, are disjoint with their siblings, have single asserted parents." - }, { - "pred" : "http://purl.obolibrary.org/obo/IAO_0000117", - "val" : "Alan Ruttenberg" - }, { - "pred" : "http://purl.obolibrary.org/obo/IAO_0000119", - "val" : "A Formal Theory of Substances, Qualities, and Universals, http://ontology.buffalo.edu/bfo/SQU.pdf" - } ] - } - }, { - "id" : "http://purl.obolibrary.org/obo/IAO_0000420", - "lbl" : "defined class", - "type" : "INDIVIDUAL", - "meta" : { - "definition" : { - "val" : "A defined class is a class that is defined by a set of logically necessary and sufficient conditions but is not a universal" - }, - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/IAO_0000111", - "val" : "defined class" - }, { - "pred" : "http://purl.obolibrary.org/obo/IAO_0000116", - "val" : "\"definitions\", in some readings, always are given by necessary and sufficient conditions. So one must be careful (and this is difficult sometimes) to distinguish between defined classes and universal." - }, { - "pred" : "http://purl.obolibrary.org/obo/IAO_0000117", - "val" : "Alan Ruttenberg" - } ] - } - }, { - "id" : "http://purl.obolibrary.org/obo/IAO_0000421", - "lbl" : "named class expression", - "type" : "INDIVIDUAL", - "meta" : { - "definition" : { - "val" : "A named class expression is a logical expression that is given a name. The name can be used in place of the expression." - }, - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/IAO_0000111", - "val" : "named class expression" - }, { - "pred" : "http://purl.obolibrary.org/obo/IAO_0000116", - "val" : "named class expressions are used in order to have more concise logical definition but their extensions may not be interesting classes on their own. In languages such as OWL, with no provisions for macros, these show up as actuall classes. Tools may with to not show them as such, and to replace uses of the macros with their expansions" - }, { - "pred" : "http://purl.obolibrary.org/obo/IAO_0000117", - "val" : "Alan Ruttenberg" - } ] - } - }, { - "id" : "http://purl.obolibrary.org/obo/IAO_0000423", - "lbl" : "to be replaced with external ontology term", - "type" : "INDIVIDUAL", - "meta" : { - "definition" : { - "val" : "Terms with this status should eventually replaced with a term from another ontology." - }, - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/IAO_0000111", - "val" : "to be replaced with external ontology term" - }, { - "pred" : "http://purl.obolibrary.org/obo/IAO_0000117", - "val" : "Alan Ruttenberg" - }, { - "pred" : "http://purl.obolibrary.org/obo/IAO_0000119", - "val" : "group:OBI" - } ] - } }, { "id" : "http://purl.obolibrary.org/obo/IAO_0000424", "lbl" : "expand expression to", - "type" : "PROPERTY", - "meta" : { - "definition" : { - "val" : "A macro expansion tag applied to an object property (or possibly a data property) which can be used by a macro-expansion engine to generate more complex expressions from simpler ones" - }, - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/IAO_0000111", - "val" : "expand expression to" - }, { - "pred" : "http://purl.obolibrary.org/obo/IAO_0000112", - "val" : "ObjectProperty: RO_0002104\nLabel: has plasma membrane part\nAnnotations: IAO_0000424 \"http://purl.obolibrary.org/obo/BFO_0000051 some (http://purl.org/obo/owl/GO#GO_0005886 and http://purl.obolibrary.org/obo/BFO_0000051 some ?Y)\"\n" - }, { - "pred" : "http://purl.obolibrary.org/obo/IAO_0000117", - "val" : "Chris Mungall" - } ] - } - }, { - "id" : "http://purl.obolibrary.org/obo/IAO_0000428", - "lbl" : "requires discussion", - "type" : "INDIVIDUAL", - "meta" : { - "definition" : { - "val" : "A term that is metadata complete, has been reviewed, and problems have been identified that require discussion before release. Such a term requires editor note(s) to identify the outstanding issues." - }, - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/IAO_0000111", - "val" : "requires discussion" - }, { - "pred" : "http://purl.obolibrary.org/obo/IAO_0000117", - "val" : "Alan Ruttenberg" - }, { - "pred" : "http://purl.obolibrary.org/obo/IAO_0000119", - "val" : "group:OBI" - } ] - } + "type" : "PROPERTY" }, { "id" : "http://purl.obolibrary.org/obo/IAO_0000700", "lbl" : "preferred_root", "type" : "PROPERTY", "meta" : { - "definition" : { - "val" : "Ontology annotation property. Relates an ontology to a term that is a designated root term of the ontology. Display tools like OLS can use terms annotated with this property as the starting point for rendering the ontology class hierarchy. There can be more than one root." - }, "xrefs" : [ { "val" : "IAO:0000700" } ], "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/IAO_0000111", - "val" : "has ontology root term" - }, { - "pred" : "http://purl.obolibrary.org/obo/IAO_0000117", - "val" : "Nicolas Matentzoglu" + "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", + "val" : "external" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "uberon" + }, { + "pred" : "http://www.geneontology.org/formats/oboInOwl#is_class_level", + "val" : "true" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#is_metadata_tag", "val" : "true" @@ -15388,26 +15111,7 @@ }, { "id" : "http://purl.obolibrary.org/obo/IAO_0100001", "lbl" : "term replaced by", - "type" : "PROPERTY", - "meta" : { - "definition" : { - "val" : "Use on obsolete terms, relating the term to another term that can be used as a substitute" - }, - "comments" : [ "Add as annotation triples in the granting ontology" ], - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/IAO_0000111", - "val" : "term replaced by" - }, { - "pred" : "http://purl.obolibrary.org/obo/IAO_0000114", - "val" : "http://purl.obolibrary.org/obo/IAO_0000125" - }, { - "pred" : "http://purl.obolibrary.org/obo/IAO_0000117", - "val" : "Person:Alan Ruttenberg" - }, { - "pred" : "http://purl.obolibrary.org/obo/IAO_0000119", - "val" : "Person:Alan Ruttenberg" - } ] - } + "type" : "PROPERTY" }, { "id" : "http://purl.obolibrary.org/obo/NCBITaxon_1", "lbl" : "root", @@ -20680,7 +20384,7 @@ "pred" : "http://purl.obolibrary.org/obo/IAO_0000118", "val" : "has_participant" }, { - "pred" : "http://purl.org/dc/elements/1.1/source", + "pred" : "http://purl.org/dc/terms/source", "val" : "http://www.obofoundry.org/ro/#OBO_REL:has_participant" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", @@ -20937,54 +20641,28 @@ "val" : "location_of" } ] } - }, { - "id" : "http://purl.obolibrary.org/obo/RO_0001018", - "lbl" : "contained in", - "type" : "PROPERTY", - "meta" : { - "subsets" : [ "http://purl.obolibrary.org/obo/ro/subsets#ro-eco" ], - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/IAO_0000111", - "val" : "contained in" - }, { - "pred" : "http://purl.obolibrary.org/obo/IAO_0000116", - "val" : "Containment is location not involving parthood, and arises only where some immaterial continuant is involved." - }, { - "pred" : "http://purl.obolibrary.org/obo/IAO_0000116", - "val" : "Containment obtains in each case between material and immaterial continuants, for instance: lung contained_in thoracic cavity; bladder contained_in pelvic cavity. Hence containment is not a transitive relation. If c part_of c1 at t then we have also, by our definition and by the axioms of mereology applied to spatial regions, c located_in c1 at t. Thus, many examples of instance-level location relations for continuants are in fact cases of instance-level parthood. For material continuants location and parthood coincide. Containment is location not involving parthood, and arises only where some immaterial continuant is involved. To understand this relation, we first define overlap for continuants as follows: c1 overlap c2 at t =def for some c, c part_of c1 at t and c part_of c2 at t. The containment relation on the instance level can then be defined (see definition):" - }, { - "pred" : "http://purl.obolibrary.org/obo/IAO_0000116", - "val" : "Intended meaning:\ndomain: material entity\nrange: spatial region or site (immaterial continuant)\n " - }, { - "pred" : "http://purl.obolibrary.org/obo/IAO_0000118", - "val" : "contained_in" - }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0001900", - "val" : "http://purl.obolibrary.org/obo/RO_0001901" - } ] - } }, { "id" : "http://purl.obolibrary.org/obo/RO_0001019", - "lbl" : "contains", + "lbl" : "obsolete contains", "type" : "PROPERTY", "meta" : { - "subsets" : [ "http://purl.obolibrary.org/obo/ro/subsets#ro-eco" ], "xrefs" : [ { "val" : "RO:0001019" } ], "basicPropertyValues" : [ { "pred" : "http://purl.obolibrary.org/obo/IAO_0000111", "val" : "contains" - }, { - "pred" : "http://purl.obolibrary.org/obo/RO_0001900", - "val" : "http://purl.obolibrary.org/obo/RO_0001901" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", "val" : "uberon" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#shorthand", "val" : "contains" - } ] + }, { + "pred" : "http://www.w3.org/2000/01/rdf-schema#seeAlso", + "val" : "https://github.com/oborel/obo-relations/issues/693" + } ], + "deprecated" : true } }, { "id" : "http://purl.obolibrary.org/obo/RO_0001025", @@ -21020,7 +20698,7 @@ "pred" : "http://purl.obolibrary.org/obo/RO_0001900", "val" : "http://purl.obolibrary.org/obo/RO_0001901" }, { - "pred" : "http://purl.org/dc/elements/1.1/source", + "pred" : "http://purl.org/dc/terms/source", "val" : "http://www.obofoundry.org/ro/#OBO_REL:located_in" }, { "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace", @@ -25876,19 +25554,6 @@ "val" : "process_has_causal_agent" } ] } - }, { - "id" : "http://purl.obolibrary.org/obo/RO_0002610", - "lbl" : "correlated with", - "type" : "PROPERTY", - "meta" : { - "definition" : { - "val" : "A relationship that holds between two entities, where the entities exhibit a statistical dependence relationship. The entities may be statistical variables, or they may be other kinds of entities such as diseases, chemical entities or processes." - }, - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/IAO_0000232", - "val" : "Groups both positive and negative correlation" - } ] - } }, { "id" : "http://purl.obolibrary.org/obo/RO_0002629", "lbl" : "directly positively regulates", @@ -26504,22 +26169,6 @@ "val" : "2021-11-08T12:00:00Z" } ] } - }, { - "id" : "http://purl.obolibrary.org/obo/RO_0017003", - "lbl" : "positively correlated with", - "type" : "PROPERTY", - "meta" : { - "definition" : { - "val" : "A relation between entities in which one increases or decreases as the other does the same." - }, - "basicPropertyValues" : [ { - "pred" : "http://purl.obolibrary.org/obo/IAO_0000118", - "val" : "directly correlated with" - }, { - "pred" : "http://purl.org/dc/terms/contributor", - "val" : "https://orcid.org/0000-0003-1909-9269" - } ] - } }, { "id" : "http://purl.obolibrary.org/obo/RO_0019000", "lbl" : "regulates characteristic", @@ -40211,6 +39860,14 @@ "sub" : "http://purl.obolibrary.org/obo/CL_0011115", "pred" : "http://purl.obolibrary.org/obo/RO_0002215", "obj" : "http://purl.obolibrary.org/obo/GO_0030154" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0017005", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/CL_0000542" + }, { + "sub" : "http://purl.obolibrary.org/obo/CL_0017005", + "pred" : "http://purl.obolibrary.org/obo/RO_0002353", + "obj" : "http://purl.obolibrary.org/obo/GO_0046649" }, { "sub" : "http://purl.obolibrary.org/obo/CL_0017006", "pred" : "is_a", @@ -41561,6 +41218,10 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0008219", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/GO_0009987" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0008283", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009987" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0009058", "pred" : "is_a", @@ -41569,6 +41230,10 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0009059", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/GO_0043170" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0009059", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0044249" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0009059", "pred" : "is_a", @@ -41640,7 +41305,7 @@ }, { "sub" : "http://purl.obolibrary.org/obo/GO_0010467", "pred" : "is_a", - "obj" : "http://purl.obolibrary.org/obo/GO_0043170" + "obj" : "http://purl.obolibrary.org/obo/GO_0009059" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0012501", "pred" : "is_a", @@ -41897,6 +41562,10 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0023061", "pred" : "http://purl.obolibrary.org/obo/BFO_0000050", "obj" : "http://purl.obolibrary.org/obo/GO_0007267" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0030030", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0008283" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0030030", "pred" : "is_a", @@ -42625,6 +42294,14 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0044238", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/GO_0008152" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0044249", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0009058" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0044249", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/GO_0044237" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0044419", "pred" : "is_a", @@ -43657,6 +43334,10 @@ "sub" : "http://purl.obolibrary.org/obo/GO_0110165", "pred" : "is_a", "obj" : "http://purl.obolibrary.org/obo/GO_0005575" + }, { + "sub" : "http://purl.obolibrary.org/obo/GO_0110165", + "pred" : "is_a", + "obj" : "http://purl.obolibrary.org/obo/UBERON_0000061" }, { "sub" : "http://purl.obolibrary.org/obo/GO_0120025", "pred" : "is_a", @@ -49145,10 +48826,6 @@ "sub" : "http://purl.obolibrary.org/obo/RO_0015016", "pred" : "subPropertyOf", "obj" : "http://purl.obolibrary.org/obo/RO_0002104" - }, { - "sub" : "http://purl.obolibrary.org/obo/RO_0017003", - "pred" : "subPropertyOf", - "obj" : "http://purl.obolibrary.org/obo/RO_0002610" }, { "sub" : "http://purl.obolibrary.org/obo/RO_0019000", "pred" : "subPropertyOf", @@ -49269,10 +48946,6 @@ "sub" : "http://purl.obolibrary.org/obo/RO_0001015", "pred" : "inverseOf", "obj" : "http://purl.obolibrary.org/obo/RO_0001025" - }, { - "sub" : "http://purl.obolibrary.org/obo/RO_0001018", - "pred" : "inverseOf", - "obj" : "http://purl.obolibrary.org/obo/RO_0001019" }, { "sub" : "http://purl.obolibrary.org/obo/RO_0002000", "pred" : "inverseOf", @@ -53119,10 +52792,6 @@ }, { "predicateId" : "http://purl.obolibrary.org/obo/RO_0000091", "domainClassIds" : [ "http://purl.obolibrary.org/obo/BFO_0000004" ] - }, { - "predicateId" : "http://purl.obolibrary.org/obo/RO_0001018", - "domainClassIds" : [ "http://purl.obolibrary.org/obo/BFO_0000040" ], - "rangeClassIds" : [ "http://purl.obolibrary.org/obo/BFO_0000004" ] }, { "predicateId" : "http://purl.obolibrary.org/obo/RO_0001025", "domainClassIds" : [ "http://purl.obolibrary.org/obo/BFO_0000004" ], @@ -53424,9 +53093,6 @@ }, { "predicateId" : "http://purl.obolibrary.org/obo/RO_0002314", "chainPredicateIds" : [ "http://purl.obolibrary.org/obo/RO_0000052", "http://purl.obolibrary.org/obo/BFO_0000050" ] - }, { - "predicateId" : "http://purl.obolibrary.org/obo/RO_0001018", - "chainPredicateIds" : [ "http://purl.obolibrary.org/obo/RO_0001025", "http://purl.obolibrary.org/obo/BFO_0000050" ] }, { "predicateId" : "http://purl.obolibrary.org/obo/RO_0001025", "chainPredicateIds" : [ "http://purl.obolibrary.org/obo/RO_0001025", "http://purl.obolibrary.org/obo/BFO_0000050" ] diff --git a/src/ontology/subsets/blood_and_immune_upper_slim.obo b/src/ontology/subsets/blood_and_immune_upper_slim.obo index af88c78d1..ddd8f9a14 100644 --- a/src/ontology/subsets/blood_and_immune_upper_slim.obo +++ b/src/ontology/subsets/blood_and_immune_upper_slim.obo @@ -1,5 +1,5 @@ format-version: 1.2 -data-version: cl/releases/2023-07-20/subsets/blood_and_immune_upper_slim.owl +data-version: cl/releases/2023-08-24/subsets/blood_and_immune_upper_slim.owl subsetdef: abnormal_slim "" subsetdef: added_for_HCA "" subsetdef: attribute_slim "" @@ -95,7 +95,7 @@ synonymtypedef: synonym "" synonymtypedef: SYSTEMATIC "" synonymtypedef: systematic_synonym "" ontology: cl/subsets/blood_and_immune_upper_slim -property_value: owl:versionInfo "2023-07-20" xsd:string +property_value: owl:versionInfo "2023-08-24" xsd:string [Term] id: BFO:0000002 @@ -311,7 +311,7 @@ subset: human_reference_atlas synonym: "blood forming stem cell" EXACT [] synonym: "colony forming unit hematopoietic" RELATED [] synonym: "hemopoietic stem cell" EXACT [] -synonym: "HSC" EXACT [] +synonym: "HSC" RELATED abbreviation [] xref: BTO:0000725 xref: CALOHA:TS-0448 xref: FMA:70337 @@ -357,10 +357,10 @@ id: CL:0000038 name: erythroid progenitor cell def: "A progenitor cell committed to the erythroid lineage." [GOC:add, ISBN:0721601464] subset: blood_and_immune_upper_slim -synonym: "BFU-E" RELATED [] +synonym: "BFU-E" RELATED abbreviation [] synonym: "blast forming unit erythroid" RELATED [] synonym: "burst forming unit erythroid" RELATED [] -synonym: "CFU-E" RELATED [] +synonym: "CFU-E" RELATED abbreviation [] synonym: "colony forming unit erythroid" RELATED [] synonym: "erythroid stem cell" RELATED [] xref: BTO:0004911 @@ -373,7 +373,7 @@ id: CL:0000040 name: monoblast def: "A myeloid progenitor cell committed to the monocyte lineage. This cell is CD11b-positive, has basophilic cytoplasm, euchromatin, and the presence of a nucleolus." [GOC:add, http://en.wikipedia.org/wiki/Monoblast, http://www.copewithcytokines.de, PMID:1104740] comment: Morphology: mononuclear cell, diameter 12-20 _M, non-granular, N/C ratio 3/1 - 4/1; markers: CD11b (shared with many other myeloid cells); location: Adult: bone marrow; fetal: liver, Yolk Sac; role or process: hematopoiesis, monocyte development; lineage: hematopoietic, myeloid. -synonym: "CFU-M" RELATED [] +synonym: "CFU-M" RELATED abbreviation [] synonym: "colony forming unit macrophage" RELATED [] synonym: "colony forming unit monocyte" RELATED [] synonym: "monocyte stem cell" RELATED [] @@ -416,9 +416,9 @@ name: common myeloid progenitor def: "A progenitor cell committed to myeloid lineage, including the megakaryocyte and erythroid lineages." [GOC:add, ISBN:0878932437, MESH:D023461] comment: This cell type is intended to be compatible with any vertebrate common myeloid progenitor. For mammalian CMP known to be CD34-positive, please use the term 'common myeloid progenitor, CD34-positive' (CL_0001059). subset: human_reference_atlas -synonym: "CFU-GEMM" RELATED [ISBN:0878932437] -synonym: "CFU-S" RELATED [ISBN:0878932437] -synonym: "CMP" EXACT [ISBN:0878932437] +synonym: "CFU-GEMM" RELATED abbreviation [ISBN:0878932437] +synonym: "CFU-S" RELATED abbreviation [ISBN:0878932437] +synonym: "CMP" RELATED abbreviation [ISBN:0878932437] synonym: "colony forming unit granulocyte, erythrocyte, macrophage, and megakaryocyte" RELATED [ISBN:0878932437] synonym: "common myeloid precursor" EXACT [] synonym: "multipotential myeloid stem cell" RELATED [ISBN:0878932437] @@ -462,13 +462,13 @@ name: common lymphoid progenitor def: "A oligopotent progenitor cell committed to the lymphoid lineage." [GOC:add, GOC:dsd, GOC:tfm, PMID:10407577, PMID:16551251] comment: CLP are CD7-positive, CD10-positive, CD19-negative, CD34-positive, CD45RA-positive, CD79a-negative, CD127-positive, AA4.1-positive, RAG-negative, Sca-1-low, sIgM-negative, sIgD-negative, TdT-negative, Vpre-B-negative, and pre-BCR-negative. Expression of transcription factors include E2A-positive, EBF-positive, Ikaros-negative, PU.1-negative, and Pax5-negative. subset: human_reference_atlas -synonym: "CLP" EXACT [] +synonym: "CLP" RELATED abbreviation [] synonym: "committed lymphopoietic stem cell" RELATED [] synonym: "common lymphocyte precursor" EXACT [] synonym: "common lymphocyte progenitor" EXACT [] synonym: "common lymphoid precursor" EXACT [] synonym: "early lymphocyte progenitor" RELATED [] -synonym: "ELP" RELATED [] +synonym: "ELP" RELATED abbreviation [] synonym: "lymphoid stem cell" RELATED [] synonym: "lymphopoietic stem cell" RELATED [] is_a: CL:0002032 {is_inferred="true"} ! hematopoietic oligopotent progenitor cell @@ -541,6 +541,7 @@ is_a: CL:0000548 ! animal cell disjoint_from: CL:0000738 ! leukocyte relationship: part_of UBERON:0000483 ! epithelium relationship: present_in_taxon NCBITaxon:9606 +property_value: depicted_by "https://www.swissbiopics.org/api/image/Epithelial_cells.svg" xsd:anyURI [Term] id: CL:0000071 @@ -746,9 +747,9 @@ id: CL:0000134 name: mesenchymal stem cell def: "A connective tissue cell that normally gives rise to other cells that are organized as three-dimensional masses. In humans, this cell type is CD73-positive, CD90-positive, CD105-positive, CD45-negative, CD34-negative, and MHCII-negative. They may further differentiate into osteoblasts, adipocytes, myocytes, neurons, or chondroblasts in vitro. Originally described as residing in the bone marrow, this cell type is now known to reside in many, if not all, adult organs." [FB:ma, GOC:dsd, http://en.wikipedia.org/wiki/Mesenchymal_stem_cell, http://www.copewithcytokines.de/cope.cgi?key=mesenchymal%20stem%20cells, PMCID:PMC2613570, PMID:10102814, PMID:16923606, PMID:17986482, PMID:19960544] comment: Many but not all mesenchymal cells derive from the mesoderm. MSCs are reportedly CD3-negative, CD4-negative, CD5-negative, CD8-negative, CD11a-negative, CD11b-negative, CD14-negative, CD19-negative, CD29-positive, CD31-negative, CD34-negative, CD38-negative, CD40-negative, CD44-positive, CD45-negative, CD49-positive, CD54-positive, CD66b-negative, CD79a-negative, CD80-negative, CD102-positive, CD106-positive, CD117-positive, CD121a-positive, CD121b-positive, CD123-positive, CD124-positive, CD133-negative, CD146-positive, CD166-positive, CD271-positive, B220-negative, Gr1-negative, MHCI-positive, MHCII-negative, SSEA4-negative, sca1-positive, Ter119-negative, and glycophorin A-negative. Cultured MSCs are capable of producing stem cell factor, IL7, IL8, IL11, TGF-beta, cofilin, galectin-1, laminin-receptor 1, cyclophilin A, and MMP-2. -synonym: "BMSC" NARROW [] +synonym: "BMSC" RELATED abbreviation [] synonym: "bone marrow stromal cells" NARROW [] -synonym: "CFU-F" RELATED [] +synonym: "CFU-F" RELATED abbreviation [] synonym: "colony-forming unit-fibroblast" NARROW [] synonym: "marrow stromal cells" NARROW [PMID:11378515] synonym: "mesenchymal precursor cell" RELATED [] @@ -756,7 +757,7 @@ synonym: "mesenchymal progenitor cells" RELATED PLURAL [MESH:D044982] synonym: "mesenchymal stem cell" RELATED [] synonym: "mesenchymal stromal cell" RELATED [] synonym: "mesenchymal stromal cells" RELATED PLURAL [] -synonym: "MSC" RELATED [PMID:11378515] +synonym: "MSC" RELATED abbreviation [PMID:11378515] synonym: "stem cells, mesenchymal" RELATED PLURAL [MESH:D044982] xref: BTO:0002625 xref: BTO:0003298 @@ -771,7 +772,7 @@ name: professional antigen presenting cell def: "A cell capable of processing and presenting lipid and protein antigens to T cells in order to initiate an immune response." [GOC:add, ISBN:0781735149] comment: Note change of name; nearly all somatic cells can present antigens to T cells via MHC Class I complexes leading to effector responses, but professional antigen presenting cells constitutively express MHC Class II as well as costimulatory molecules, and thus can initiate immune responses via T cells. subset: blood_and_immune_upper_slim -synonym: "APC" BROAD [] +synonym: "APC" RELATED abbreviation [] is_a: CL:0000738 ! leukocyte intersection_of: CL:0000738 ! leukocyte intersection_of: capable_of GO:0002504 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II @@ -812,6 +813,7 @@ is_a: CL:0000183 ! contractile cell is_a: CL:0000393 ! electrically responsive cell is_a: CL:0002371 ! somatic cell relationship: develops_from CL:0000056 ! myoblast +property_value: depicted_by "https://www.swissbiopics.org/api/image/Muscle_cells.svg" xsd:anyURI [Term] id: CL:0000211 @@ -1040,7 +1042,7 @@ relationship: capable_of GO:0015671 ! oxygen transport [Term] id: CL:0000333 name: migratory neural crest cell -def: "A cell derived from the specialized ectoderm flanking each side of the embryonic neural plate, which after the closure of the neural tube, forms masses of cells that migrate out from the dorsal aspect of the neural tube to spread throughout the body." [MESH:A16.254.600] +def: "A cell derived from the specialized ectoderm flanking each side of the embryonic neural plate, which after the closure of the neural tube, forms masses of cells that migrate out from the dorsal aspect of the neural tube to spread throughout the body." [doi:10.1016/j.stem.2015.02.017] xref: FMA:86667 is_a: CL:0000219 ! motile cell is_a: CL:0011012 ! neural crest cell @@ -1163,6 +1165,7 @@ is_a: CL:0000404 ! electrically signaling cell is_a: CL:0002319 ! neural cell relationship: capable_of GO:0019226 ! transmission of nerve impulse relationship: present_in_taxon NCBITaxon:9606 +property_value: depicted_by "https://www.swissbiopics.org/api/image/Neuron_cells.svg" xsd:anyURI [Term] id: CL:0000542 @@ -1192,7 +1195,7 @@ relationship: present_in_taxon NCBITaxon:9606 [Term] id: CL:0000547 name: proerythroblast -def: "An immature, nucleated erythrocyte occupying the stage of erythropoeisis that follows formation of erythroid progenitor cells. This cell is CD71-positive, has both a nucleus and a nucleolus, and lacks hematopoeitic lineage markers." [ISBN:0721601464, MESH:A11.118.290.350.200, PMID:1638021] +def: "An immature, nucleated erythrocyte occupying the stage of erythropoeisis that follows formation of erythroid progenitor cells. This cell is CD71-positive, has both a nucleus and a nucleolus, and lacks hematopoeitic lineage markers." [ISBN:0721601464, PMID:1638021] subset: blood_and_immune_upper_slim synonym: "pronormoblast" RELATED [] synonym: "rubriblast" EXACT [ISBN:0721601464] @@ -1244,6 +1247,7 @@ is_a: CL:0000255 ! eukaryotic cell intersection_of: CL:0000003 ! native cell intersection_of: only_in_taxon NCBITaxon:33208 ! Metazoa relationship: only_in_taxon NCBITaxon:33208 ! Metazoa +property_value: depicted_by "https://www.swissbiopics.org/api/image/Animal_cells.svg" xsd:anyURI [Term] id: CL:0000549 @@ -1384,9 +1388,9 @@ def: "A hematopoietic progenitor cell that is committed to the granulocyte and m comment: Originally described in the dendritic cell ontology (DC_CL:0000042)(PMID:19243617). GMPs are reportedly CD16-positive, CD32-positive, CD34-positive, CD38-positive, CD45RA-positive, CD110-negative, CD117-positive, CD123-positive, and SCA1-negative. subset: human_reference_atlas synonym: "CFU-C , Colony forming unit in culture" BROAD [http://www.copewithcytokines.de] -synonym: "CFU-GM" EXACT [ISBN:0721601464, PMCID:PMC2213186, PMCID:PMC548021] +synonym: "CFU-GM" RELATED abbreviation [ISBN:0721601464, PMCID:PMC2213186, PMCID:PMC548021] synonym: "colony forming unit granulocyte macrophage" EXACT [ISBN:0721601464, PMCID:PMC2213186, PMCID:PMC548021] -synonym: "GMP" EXACT [ISBN:0721601464, PMCID:PMC2213186, PMCID:PMC548021] +synonym: "GMP" RELATED abbreviation [ISBN:0721601464, PMCID:PMC2213186, PMCID:PMC548021] synonym: "granulocyte-macrophage progenitor" EXACT [ISBN:0721601464, PMCID:PMC2213186, PMCID:PMC548021] synonym: "granulocyte/monocyte precursor" EXACT [] synonym: "granulocyte/monocyte progenitor" EXACT [] @@ -1894,7 +1898,7 @@ synonym: "gamma-delta T lymphocyte" EXACT [] synonym: "gamma-delta T-cell" EXACT [] synonym: "gamma-delta T-lymphocyte" EXACT [] synonym: "gammadelta T cell" EXACT [] -synonym: "gd T cell" RELATED [] +synonym: "gd T cell" RELATED abbreviation [] is_a: CL:0000084 {is_inferred="true"} ! T cell intersection_of: CL:0000084 ! T cell intersection_of: RO:0002104 GO:0042106 ! has plasma membrane part gamma-delta T cell receptor complex @@ -2817,6 +2821,8 @@ subset: blood_and_immune_upper_slim xref: BTO:0000772 xref: EFO:0000572 xref: FMA:83030 +is_a: CL:0000542 ! lymphocyte +relationship: output_of GO:0046649 ! lymphocyte activation property_value: http://purl.org/dc/elements/1.1/date "2022-08-17T14:20:01Z" xsd:string created_by: http://orcid.org/0000-0003-2473-2313 @@ -4985,10 +4991,28 @@ id: GO:0008219 name: cell death namespace: biological_process def: "Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538)." [GOC:mah, GOC:mtg_apoptosis, PMID:25236395] -comment: This term should not be used for direct annotation. The only exception should be when experimental data (e.g., staining with trypan blue or propidium iodide) show that cell death has occurred, but fail to provide details on death modality (accidental versus programmed). When information is provided on the cell death mechanism, annotations should be made to the appropriate descendant of 'cell death' (such as, but not limited to, GO:0097300 'programmed necrotic cell death' or GO:0006915 'apoptotic process'). Also, if experimental data suggest that a gene product influences cell death indirectly, rather than being involved in the death process directly, consider annotating to a 'regulation' term. +comment: This term should not be used for direct annotation, it is currently kept in GO as a placeholder for describing cell death phenotypes in uPHENO. When information is provided on a programmed cell death mechanism, annotations should be made to the appropriate descendant of 'cell death' (such as, but not limited to, GO:0097300 'programmed necrotic cell death' or GO:0006915 'apoptotic process'). Unintentional cell death, i.e. cell death caused by injury, ageing, or cell phenotypes observed as a result of a pathological mutation in an essential gene should NOT be annotated using GO terms. +subset: gocheck_do_not_annotate synonym: "accidental cell death" RELATED [] synonym: "necrosis" RELATED [] is_a: GO:0009987 ! cellular process +property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/24680" xsd:anyURI + +[Term] +id: GO:0008283 +name: cell population proliferation +namespace: biological_process +def: "The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb] +comment: This term was moved out from being a child of 'cellular process' because it is a cell population-level process, and cellular processes are restricted to those processes that involve individual cells. Also note that this term is intended to be used for the proliferation of cells within a multicellular organism, not for the expansion of a population of single-celled organisms. +subset: goslim_agr +subset: goslim_chembl +subset: goslim_drosophila +subset: goslim_flybase_ribbon +subset: goslim_mouse +subset: goslim_pir +synonym: "cell proliferation" RELATED [] +is_a: GO:0009987 ! cellular process +relationship: never_in_taxon NCBITaxon:4751 [Term] id: GO:0009058 @@ -5024,8 +5048,10 @@ synonym: "macromolecule biosynthesis" EXACT [] synonym: "macromolecule formation" EXACT [] synonym: "macromolecule synthesis" EXACT [] is_a: GO:0043170 ! macromolecule metabolic process +is_a: GO:0044249 ! cellular biosynthetic process is_a: GO:1901576 ! organic substance biosynthetic process -property_value: term_tracker_item "http://amigo.geneontology.org/amigo/term/GO:0070589" xsd:anyURI +property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/15249" xsd:anyURI +property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/25418" xsd:anyURI [Term] id: GO:0009605 @@ -5165,11 +5191,12 @@ creation_date: 2013-12-02T13:58:34Z id: GO:0010467 name: gene expression namespace: biological_process -def: "The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, translation and maturation for protein-coding genes." [GOC:txnOH-2018, PMID:25934543, PMID:31580950] +def: "The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, as well as translation and maturation for protein-coding genes." [GOC:txnOH-2018, PMID:25934543, PMID:31580950] subset: goslim_flybase_ribbon xref: Wikipedia:Gene_expression -is_a: GO:0043170 ! macromolecule metabolic process +is_a: GO:0009059 ! macromolecule biosynthetic process property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/22557" xsd:anyURI +property_value: term_tracker_item "https://github.com/geneontology/go-ontology/issues/25419" xsd:anyURI [Term] id: GO:0012501 @@ -5617,6 +5644,7 @@ subset: prokaryote_subset synonym: "cell projection organisation" EXACT [] synonym: "cell projection organization and biogenesis" RELATED [GOC:mah] synonym: "cell surface structure organization and biogenesis" RELATED [GOC:mah] +is_a: GO:0008283 ! cell population proliferation is_a: GO:0016043 ! cellular component organization intersection_of: GO:0016043 ! cellular component organization intersection_of: results_in_organization_of GO:0042995 ! cell projection @@ -6840,6 +6868,18 @@ subset: goslim_pir synonym: "primary metabolism" EXACT [] is_a: GO:0008152 ! metabolic process +[Term] +id: GO:0044249 +name: cellular biosynthetic process +namespace: biological_process +def: "The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells." [GOC:jl] +synonym: "cellular anabolism" EXACT [] +synonym: "cellular biosynthesis" EXACT [] +synonym: "cellular formation" EXACT [] +synonym: "cellular synthesis" EXACT [] +is_a: GO:0009058 ! biosynthetic process +is_a: GO:0044237 ! cellular metabolic process + [Term] id: GO:0044419 name: biological process involved in interspecies interaction between organisms @@ -8356,6 +8396,7 @@ def: "A part of a cellular organism that is either an immaterial entity or a mat subset: goslim_pir is_a: CARO:0000000 ! anatomical entity is_a: GO:0005575 ! cellular_component +is_a: UBERON:0000061 ! anatomical structure created_by: kmv creation_date: 2019-08-12T18:01:37Z @@ -15991,16 +16032,6 @@ id: CL:4030046 name: lacks_plasma_membrane_part expand_expression_to: "http://purl.obolibrary.org/obo/BFO_0000051 exactly 0 (http://purl.obolibrary.org/obo/GO_0005886 and http://purl.obolibrary.org/obo/BFO_0000051 some ?Y)" [] -[Typedef] -id: IAO:0000136 -name: is about -def: "A (currently) primitive relation that relates an information artifact to an entity." [] -property_value: editor_note "7/6/2009 Alan Ruttenberg. Following discussion with Jonathan Rees, and introduction of \"mentions\" relation. Weaken the is_about relationship to be primitive. \n\nWe will try to build it back up by elaborating the various subproperties that are more precisely defined.\n\nSome currently missing phenomena that should be considered \"about\" are predications - \"The only person who knows the answer is sitting beside me\" , Allegory, Satire, and other literary forms that can be topical without explicitly mentioning the topic." xsd:string -property_value: IAO:0000112 "This document is about information artifacts and their representations" xsd:string -property_value: IAO:0000114 IAO:0000125 -property_value: IAO:0000117 "person:Alan Ruttenberg" xsd:string -property_value: IAO:0000119 "Smith, Ceusters, Ruttenberg, 2000 years of philosophy" xsd:string - [Typedef] id: RO:0000052 name: characteristic of @@ -16111,21 +16142,6 @@ property_value: IAO:0000112 "this parent nucleus derives into this nucleus (nucl property_value: IAO:0000114 IAO:0000125 property_value: IAO:0000118 "derives_into" xsd:string -[Typedef] -id: RO:0001018 -name: contained in -subset: ro-eco -property_value: editor_note "Containment is location not involving parthood, and arises only where some immaterial continuant is involved." xsd:string -property_value: editor_note "Containment obtains in each case between material and immaterial continuants, for instance: lung contained_in thoracic cavity; bladder contained_in pelvic cavity. Hence containment is not a transitive relation. If c part_of c1 at t then we have also, by our definition and by the axioms of mereology applied to spatial regions, c located_in c1 at t. Thus, many examples of instance-level location relations for continuants are in fact cases of instance-level parthood. For material continuants location and parthood coincide. Containment is location not involving parthood, and arises only where some immaterial continuant is involved. To understand this relation, we first define overlap for continuants as follows: c1 overlap c2 at t =def for some c, c part_of c1 at t and c part_of c2 at t. The containment relation on the instance level can then be defined (see definition):" xsd:string -property_value: editor_note "Intended meaning:\ndomain: material entity\nrange: spatial region or site (immaterial continuant)\n " xsd:string -property_value: IAO:0000111 "contained in" xsd:string -property_value: IAO:0000118 "contained_in" xsd:string -property_value: RO:0001900 RO:0001901 -domain: BFO:0000040 ! material entity -range: BFO:0000004 ! independent continuant -holds_over_chain: located_in part_of -inverse_of: contains ! contains - [Typedef] id: RO:0002000 name: 2D boundary of @@ -17066,12 +17082,6 @@ property_value: IAO:0000119 http://purl.obolibrary.org/obo/ro/docs/causal-relati holds_over_chain: capable_of positively_regulates is_a: RO:0002596 ! capable of regulating -[Typedef] -id: RO:0002610 -name: correlated with -def: "A relationship that holds between two entities, where the entities exhibit a statistical dependence relationship. The entities may be statistical variables, or they may be other kinds of entities such as diseases, chemical entities or processes." [] -property_value: IAO:0000232 "Groups both positive and negative correlation" xsd:string - [Typedef] id: RO:0004031 name: enables subfunction @@ -17263,16 +17273,6 @@ property_value: IAO:0000232 "See github ticket https://github.com/oborel/obo-rel holds_over_chain: capable_of has_input creation_date: 2021-11-08T12:00:00Z -[Typedef] -id: RO:0017003 -name: positively correlated with -def: "A relation between entities in which one increases or decreases as the other does the same." [] -property_value: dc-contributor https://orcid.org/0000-0003-1909-9269 -property_value: IAO:0000118 "directly correlated with" xsd:string -is_reflexive: true -is_symmetric: true -is_a: RO:0002610 ! correlated with - [Typedef] id: acts_on_population_of name: acts on population of @@ -17585,11 +17585,12 @@ is_a: RO:0002323 ! mereotopologically related to [Typedef] id: contains name: contains +name: obsolete contains namespace: uberon -subset: ro-eco xref: RO:0001019 property_value: IAO:0000111 "contains" xsd:string -property_value: RO:0001900 RO:0001901 +property_value: seeAlso https://github.com/oborel/obo-relations/issues/693 +is_obsolete: true [Typedef] id: contains_process @@ -17864,13 +17865,7 @@ is_a: connected_to ! connected to id: editor_note name: editor note namespace: uberon -def: "An administrative note intended for its editor. It may not be included in the publication version of the ontology, so it should contain nothing necessary for end users to understand the ontology." [] xref: IAO:0000116 -property_value: IAO:0000111 "editor note" xsd:string -property_value: IAO:0000114 IAO:0000122 -property_value: IAO:0000117 "PERSON:Daniel Schober" xsd:string -property_value: IAO:0000119 "GROUP:OBI:" xsd:string -property_value: isDefinedBy http://purl.obolibrary.org/obo/iao.owl is_metadata_tag: true [Typedef] @@ -18188,12 +18183,11 @@ creation_date: 2017-05-24T09:31:01Z id: has_ontology_root_term name: has ontology root term name: preferred_root +namespace: external namespace: uberon -def: "Ontology annotation property. Relates an ontology to a term that is a designated root term of the ontology. Display tools like OLS can use terms annotated with this property as the starting point for rendering the ontology class hierarchy. There can be more than one root." [] xref: IAO:0000700 -property_value: IAO:0000111 "has ontology root term" xsd:string -property_value: IAO:0000117 "Nicolas Matentzoglu" xsd:string is_metadata_tag: true +is_class_level: true [Typedef] id: has_output @@ -18244,7 +18238,7 @@ namespace: external def: "a relation between a process and a continuant, in which the continuant is somehow involved in the process" [] xref: RO:0000057 property_value: editor_note "Has_participant is a primitive instance-level relation between a process, a continuant, and a time at which the continuant participates in some way in the process. The relation obtains, for example, when this particular process of oxygen exchange across this particular alveolar membrane has_participant this particular sample of hemoglobin at this particular time." xsd:string -property_value: http://purl.org/dc/elements/1.1/source "http://www.obofoundry.org/ro/#OBO_REL:has_participant" xsd:string +property_value: http://purl.org/dc/terms/source "http://www.obofoundry.org/ro/#OBO_REL:has_participant" xsd:string property_value: IAO:0000111 "has participant" xsd:string property_value: IAO:0000112 "this blood coagulation has participant this blood clot" xsd:string property_value: IAO:0000112 "this investigation has participant this investigator" xsd:string @@ -18638,7 +18632,7 @@ subset: http://purl.obolibrary.org/obo/valid_for_go_gp2term xref: RO:0001025 property_value: editor_note "Location as a relation between instances: The primitive instance-level relation c located_in r at t reflects the fact that each continuant is at any given time associated with exactly one spatial region, namely its exact location. Following we can use this relation to define a further instance-level location relation - not between a continuant and the region which it exactly occupies, but rather between one continuant and another. c is located in c1, in this sense, whenever the spatial region occupied by c is part_of the spatial region occupied by c1. Note that this relation comprehends both the relation of exact location between one continuant and another which obtains when r and r1 are identical (for example, when a portion of fluid exactly fills a cavity), as well as those sorts of inexact location relations which obtain, for example, between brain and head or between ovum and uterus" xsd:string property_value: editor_note "Most location relations will only hold at certain times, but this is difficult to specify in OWL. See http://purl.obolibrary.org/obo/ro/docs/temporal-semantics/" xsd:string -property_value: http://purl.org/dc/elements/1.1/source "http://www.obofoundry.org/ro/#OBO_REL:located_in" xsd:string +property_value: http://purl.org/dc/terms/source "http://www.obofoundry.org/ro/#OBO_REL:located_in" xsd:string property_value: IAO:0000111 "located in" xsd:string property_value: IAO:0000112 "my brain is located in my head" xsd:string property_value: IAO:0000112 "this rat is located in this cage" xsd:string @@ -18947,7 +18941,7 @@ def: "x is preceded by y if and only if the time point at which y ends is before subset: ro-eco xref: BFO:0000062 property_value: editor_note "An example is: translation preceded_by transcription; aging preceded_by development (not however death preceded_by aging). Where derives_from links classes of continuants, preceded_by links classes of processes. Clearly, however, these two relations are not independent of each other. Thus if cells of type C1 derive_from cells of type C, then any cell division involving an instance of C1 in a given lineage is preceded_by cellular processes involving an instance of C. The assertion P preceded_by P1 tells us something about Ps in general: that is, it tells us something about what happened earlier, given what we know about what happened later. Thus it does not provide information pointing in the opposite direction, concerning instances of P1 in general; that is, that each is such as to be succeeded by some instance of P. Note that an assertion to the effect that P preceded_by P1 is rather weak; it tells us little about the relations between the underlying instances in virtue of which the preceded_by relation obtains. Typically we will be interested in stronger relations, for example in the relation immediately_preceded_by, or in relations which combine preceded_by with a condition to the effect that the corresponding instances of P and P1 share participants, or that their participants are connected by relations of derivation, or (as a first step along the road to a treatment of causality) that the one process in some way affects (for example, initiates or regulates) the other." xsd:string -property_value: http://purl.org/dc/elements/1.1/source "http://www.obofoundry.org/ro/#OBO_REL:preceded_by" xsd:string +property_value: http://purl.org/dc/terms/source "http://www.obofoundry.org/ro/#OBO_REL:preceded_by" xsd:string property_value: IAO:0000111 "preceded by" xsd:string property_value: IAO:0000118 "is preceded by" xsd:string property_value: IAO:0000118 "preceded_by" xsd:string @@ -19481,14 +19475,7 @@ id: term_tracker_item name: term tracker item namespace: external namespace: uberon -def: "An IRI or similar locator for a request or discussion of an ontology term." [] -comment: The 'tracker item' can associate a tracker with a specific ontology term. xref: IAO:0000233 -property_value: IAO:0000111 "term tracker item" xsd:string -property_value: IAO:0000112 "the URI for an OBI Terms ticket at sourceforge, such as https://sourceforge.net/p/obi/obi-terms/772/" xsd:string -property_value: IAO:0000114 IAO:0000125 -property_value: IAO:0000117 "Person: Jie Zheng, Chris Stoeckert, Alan Ruttenberg" xsd:string -property_value: IAO:0000119 "Person: Jie Zheng, Chris Stoeckert, Alan Ruttenberg" xsd:string is_metadata_tag: true is_class_level: true diff --git a/src/ontology/subsets/blood_and_immune_upper_slim.owl b/src/ontology/subsets/blood_and_immune_upper_slim.owl index 51b38e39d..cc2783546 100644 --- a/src/ontology/subsets/blood_and_immune_upper_slim.owl +++ b/src/ontology/subsets/blood_and_immune_upper_slim.owl @@ -31,8 +31,8 @@ xmlns:oboInOwl="http://www.geneontology.org/formats/oboInOwl#" xmlns:ncbitaxon="http://purl.obolibrary.org/obo/ncbitaxon#"> - - 2023-07-20 + + 2023-08-24 @@ -50,7 +50,9 @@ - + + symbol + @@ -75,34 +77,7 @@ - definition - - The official definition, explaining the meaning of a class or property. Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions. - 2012-04-05: -Barry Smith - -The official OBI definition, explaining the meaning of a class or property: 'Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions' is terrible. - -Can you fix to something like: - -A statement of necessary and sufficient conditions explaining the meaning of an expression referring to a class or property. - -Alan Ruttenberg - -Your proposed definition is a reasonable candidate, except that it is very common that necessary and sufficient conditions are not given. Mostly they are necessary, occasionally they are necessary and sufficient or just sufficient. Often they use terms that are not themselves defined and so they effectively can't be evaluated by those criteria. - -On the specifics of the proposed definition: - -We don't have definitions of 'meaning' or 'expression' or 'property'. For 'reference' in the intended sense I think we use the term 'denotation'. For 'expression', I think we you mean symbol, or identifier. For 'meaning' it differs for class and property. For class we want documentation that let's the intended reader determine whether an entity is instance of the class, or not. For property we want documentation that let's the intended reader determine, given a pair of potential relata, whether the assertion that the relation holds is true. The 'intended reader' part suggests that we also specify who, we expect, would be able to understand the definition, and also generalizes over human and computer reader to include textual and logical definition. - -Personally, I am more comfortable weakening definition to documentation, with instructions as to what is desirable. - -We also have the outstanding issue of how to aim different definitions to different audiences. A clinical audience reading chebi wants a different sort of definition documentation/definition from a chemistry trained audience, and similarly there is a need for a definition that is adequate for an ontologist to work with. - PERSON:Daniel Schober - GROUP:OBI:<http://purl.obolibrary.org/obo/obi> - definition - definition @@ -110,19 +85,12 @@ We also have the outstanding issue of how to aim different definitions to differ - editor note - - An administrative note intended for its editor. It may not be included in the publication version of the ontology, so it should contain nothing necessary for end users to understand the ontology. - PERSON:Daniel Schober - GROUP:OBI:<http://purl.obofoundry.org/obo/obi> IAO:0000116 uberon editor_note true editor_note - editor note - editor note @@ -147,13 +115,7 @@ We also have the outstanding issue of how to aim different definitions to differ - - has obsolescence reason - Relates an annotation property to an obsolescence reason. The values of obsolescence reasons come from a list of predefined terms, instances of the class obsolescence reason specification. - PERSON:Alan Ruttenberg - PERSON:Melanie Courtot - has obsolescence reason - + @@ -166,12 +128,6 @@ We also have the outstanding issue of how to aim different definitions to differ - term tracker item - the URI for an OBI Terms ticket at sourceforge, such as https://sourceforge.net/p/obi/obi-terms/772/ - - An IRI or similar locator for a request or discussion of an ontology term. - Person: Jie Zheng, Chris Stoeckert, Alan Ruttenberg - Person: Jie Zheng, Chris Stoeckert, Alan Ruttenberg IAO:0000233 external uberon @@ -179,9 +135,7 @@ We also have the outstanding issue of how to aim different definitions to differ true true term_tracker_item - The 'tracker item' can associate a tracker with a specific ontology term. term tracker item - term tracker item @@ -189,15 +143,7 @@ We also have the outstanding issue of how to aim different definitions to differ - expand expression to - ObjectProperty: RO_0002104 -Label: has plasma membrane part -Annotations: IAO_0000424 "http://purl.obolibrary.org/obo/BFO_0000051 some (http://purl.org/obo/owl/GO#GO_0005886 and http://purl.obolibrary.org/obo/BFO_0000051 some ?Y)" - - A macro expansion tag applied to an object property (or possibly a data property) which can be used by a macro-expansion engine to generate more complex expressions from simpler ones - Chris Mungall expand expression to - expand expression to @@ -229,16 +175,14 @@ Annotations: IAO_0000424 "http://purl.obolibrary.org/obo/BFO_0000051 some ( - has ontology root term - Ontology annotation property. Relates an ontology to a term that is a designated root term of the ontology. Display tools like OLS can use terms annotated with this property as the starting point for rendering the ontology class hierarchy. There can be more than one root. - Nicolas Matentzoglu IAO:0000700 + external uberon has_ontology_root_term + true true has_ontology_root_term has ontology root term - has ontology root term preferred_root @@ -253,14 +197,7 @@ Annotations: IAO_0000424 "http://purl.obolibrary.org/obo/BFO_0000051 some ( - term replaced by - - Use on obsolete terms, relating the term to another term that can be used as a substitute - Person:Alan Ruttenberg - Person:Alan Ruttenberg - Add as annotation triples in the granting ontology term replaced by - term replaced by @@ -1433,12 +1370,6 @@ WHERE { - - - - - - @@ -1503,6 +1434,12 @@ WHERE { + + + + + + @@ -2070,7 +2007,7 @@ A continuant cannot have an occurrent as part: use 'participates in'. An example is: translation preceded_by transcription; aging preceded_by development (not however death preceded_by aging). Where derives_from links classes of continuants, preceded_by links classes of processes. Clearly, however, these two relations are not independent of each other. Thus if cells of type C1 derive_from cells of type C, then any cell division involving an instance of C1 in a given lineage is preceded_by cellular processes involving an instance of C. The assertion P preceded_by P1 tells us something about Ps in general: that is, it tells us something about what happened earlier, given what we know about what happened later. Thus it does not provide information pointing in the opposite direction, concerning instances of P1 in general; that is, that each is such as to be succeeded by some instance of P. Note that an assertion to the effect that P preceded_by P1 is rather weak; it tells us little about the relations between the underlying instances in virtue of which the preceded_by relation obtains. Typically we will be interested in stronger relations, for example in the relation immediately_preceded_by, or in relations which combine preceded_by with a condition to the effect that the corresponding instances of P and P1 share participants, or that their participants are connected by relations of derivation, or (as a first step along the road to a treatment of causality) that the one process in some way affects (for example, initiates or regulates) the other. is preceded by preceded_by - http://www.obofoundry.org/ro/#OBO_REL:preceded_by + http://www.obofoundry.org/ro/#OBO_REL:preceded_by BFO:0000062 external uberon @@ -2502,24 +2439,6 @@ A continuant cannot have an occurrent as part: use 'participates in'. - - - - This document is about information artifacts and their representations - - A (currently) primitive relation that relates an information artifact to an entity. - 7/6/2009 Alan Ruttenberg. Following discussion with Jonathan Rees, and introduction of "mentions" relation. Weaken the is_about relationship to be primitive. - -We will try to build it back up by elaborating the various subproperties that are more precisely defined. - -Some currently missing phenomena that should be considered "about" are predications - "The only person who knows the answer is sitting beside me" , Allegory, Satire, and other literary forms that can be topical without explicitly mentioning the topic. - person:Alan Ruttenberg - Smith, Ceusters, Ruttenberg, 2000 years of philosophy - is about - - - - @@ -2600,7 +2519,7 @@ Some currently missing phenomena that should be considered "about" are a relation between a process and a continuant, in which the continuant is somehow involved in the process Has_participant is a primitive instance-level relation between a process, a continuant, and a time at which the continuant participates in some way in the process. The relation obtains, for example, when this particular process of oxygen exchange across this particular alveolar membrane has_participant this particular sample of hemoglobin at this particular time. has_participant - http://www.obofoundry.org/ro/#OBO_REL:has_participant + http://www.obofoundry.org/ro/#OBO_REL:has_participant RO:0000057 external has_participant @@ -2783,43 +2702,18 @@ Some currently missing phenomena that should be considered "about" are - - - - - - - - - - - contained in - Containment is location not involving parthood, and arises only where some immaterial continuant is involved. - Containment obtains in each case between material and immaterial continuants, for instance: lung contained_in thoracic cavity; bladder contained_in pelvic cavity. Hence containment is not a transitive relation. If c part_of c1 at t then we have also, by our definition and by the axioms of mereology applied to spatial regions, c located_in c1 at t. Thus, many examples of instance-level location relations for continuants are in fact cases of instance-level parthood. For material continuants location and parthood coincide. Containment is location not involving parthood, and arises only where some immaterial continuant is involved. To understand this relation, we first define overlap for continuants as follows: c1 overlap c2 at t =def for some c, c part_of c1 at t and c part_of c2 at t. The containment relation on the instance level can then be defined (see definition): - Intended meaning: -domain: material entity -range: spatial region or site (immaterial continuant) - - contained_in - - - contained in - - - - contains - RO:0001019 uberon contains - contains contains - contains + obsolete contains + + true @@ -2842,7 +2736,7 @@ range: spatial region or site (immaterial continuant) Most location relations will only hold at certain times, but this is difficult to specify in OWL. See http://purl.obolibrary.org/obo/ro/docs/temporal-semantics/ located_in - http://www.obofoundry.org/ro/#OBO_REL:located_in + http://www.obofoundry.org/ro/#OBO_REL:located_in RO:0001025 uberon located_in @@ -6924,16 +6818,6 @@ For example, A and B may be gene products and binding of B by A positively regul - - - - A relationship that holds between two entities, where the entities exhibit a statistical dependence relationship. The entities may be statistical variables, or they may be other kinds of entities such as diseases, chemical entities or processes. - Groups both positive and negative correlation - correlated with - - - - @@ -7462,27 +7346,13 @@ For example, A and B may be gene products and binding of B by A positively regul A diagnostic testing device utilizes a specimen means that the diagnostic testing device is capable of an assay, and this assay a specimen as its input. See github ticket https://github.com/oborel/obo-relations/issues/497 - 2021-11-08T12:00:00Z + 2021-11-08T12:00:00Z utilizes device utilizes material - - - - - - - A relation between entities in which one increases or decreases as the other does the same. - directly correlated with - - positively correlated with - - - - @@ -8157,7 +8027,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + @@ -8173,7 +8043,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process multicellular anatomical structure - + @@ -8185,7 +8055,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + There is a cost to burying this in PATO. We lose that we could relax the cardinality assertion to subClassOf has_part some cell. I'm sure having this axiom inherited would come in handy. DOS @@ -8552,9 +8422,9 @@ MH: sexual subtypes should probably be logically defined based on sexual process FMA:86475 MESH:D006412 VHOG:0001485 - HSC blood forming stem cell hemopoietic stem cell + HSC colony forming unit hematopoietic @@ -8571,6 +8441,12 @@ MH: sexual subtypes should probably be logically defined based on sexual process PMID:19022770 http://en.wikipedia.org/wiki/Hematopoietic_stem_cell + + + + HSC + + @@ -8609,6 +8485,18 @@ MH: sexual subtypes should probably be logically defined based on sexual process GOC:add ISBN:0721601464 + + + + BFU-E + + + + + + CFU-E + + @@ -8700,6 +8588,12 @@ MH: sexual subtypes should probably be logically defined based on sexual process http://en.wikipedia.org/wiki/Monoblast http://www.copewithcytokines.de + + + + CFU-M + + @@ -8756,10 +8650,10 @@ MH: sexual subtypes should probably be logically defined based on sexual process A progenitor cell committed to myeloid lineage, including the megakaryocyte and erythroid lineages. BTO:0004730 - CMP common myeloid precursor CFU-GEMM CFU-S + CMP colony forming unit granulocyte, erythrocyte, macrophage, and megakaryocyte multipotential myeloid stem cell myeloid stem cell @@ -8784,21 +8678,24 @@ MH: sexual subtypes should probably be logically defined based on sexual process - - CMP + + CFU-GEMM ISBN:0878932437 + - CFU-GEMM + CFU-S ISBN:0878932437 + - CFU-S + CMP ISBN:0878932437 + @@ -8919,10 +8816,10 @@ MH: sexual subtypes should probably be logically defined based on sexual process A oligopotent progenitor cell committed to the lymphoid lineage. - CLP common lymphocyte precursor common lymphocyte progenitor common lymphoid precursor + CLP ELP committed lymphopoietic stem cell early lymphocyte progenitor @@ -8948,6 +8845,18 @@ MH: sexual subtypes should probably be logically defined based on sexual process PMID:10407577 PMID:16551251 + + + + CLP + + + + + + ELP + + @@ -9070,6 +8979,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process epithelial cell + https://www.swissbiopics.org/api/image/Epithelial_cells.svg @@ -9796,10 +9706,10 @@ MH: sexual subtypes should probably be logically defined based on sexual process BTO:0002625 BTO:0003298 FMA:70546 - BMSC bone marrow stromal cells colony-forming unit-fibroblast marrow stromal cells + BMSC CFU-F MSC mesenchymal precursor cell @@ -9838,11 +9748,24 @@ MH: sexual subtypes should probably be logically defined based on sexual process marrow stromal cells PMID:11378515 + + + + BMSC + + + + + + CFU-F + + MSC PMID:11378515 + @@ -9889,7 +9812,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process A cell capable of processing and presenting lipid and protein antigens to T cells in order to initiate an immune response. - APC + APC Note change of name; nearly all somatic cells can present antigens to T cells via MHC Class I complexes leading to effector responses, but professional antigen presenting cells constitutively express MHC Class II as well as costimulatory molecules, and thus can initiate immune responses via T cells. professional antigen presenting cell @@ -9901,6 +9824,12 @@ MH: sexual subtypes should probably be logically defined based on sexual process GOC:add ISBN:0781735149 + + + + APC + + @@ -9980,6 +9909,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process muscle fiber myocyte muscle cell + https://www.swissbiopics.org/api/image/Muscle_cells.svg @@ -10653,7 +10583,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process A cell derived from the specialized ectoderm flanking each side of the embryonic neural plate, which after the closure of the neural tube, forms masses of cells that migrate out from the dorsal aspect of the neural tube to spread throughout the body. - MESH:A16.254.600 + doi:10.1016/j.stem.2015.02.017 @@ -10970,6 +10900,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process These cells are also reportedly CD4-negative and CD200-positive. They are also capable of producing CD40L and IFN-gamma. neuron + https://www.swissbiopics.org/api/image/Neuron_cells.svg @@ -11247,7 +11178,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process An immature, nucleated erythrocyte occupying the stage of erythropoeisis that follows formation of erythroid progenitor cells. This cell is CD71-positive, has both a nucleus and a nucleolus, and lacks hematopoeitic lineage markers. ISBN:0721601464 - MESH:A11.118.290.350.200 PMID:1638021 @@ -11284,6 +11214,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process metazoan cell animal cell + https://www.swissbiopics.org/api/image/Animal_cells.svg @@ -11932,12 +11863,12 @@ MH: sexual subtypes should probably be logically defined based on sexual process A hematopoietic progenitor cell that is committed to the granulocyte and monocyte lineages. These cells are CD123-positive, and do not express Gata1 or Gata2 but do express C/EBPa, and Pu.1. CFU-C , Colony forming unit in culture - CFU-GM - GMP colony forming unit granulocyte macrophage granulocyte-macrophage progenitor granulocyte/monocyte precursor granulocyte/monocyte progenitor + CFU-GM + GMP Originally described in the dendritic cell ontology (DC_CL:0000042)(PMID:19243617). GMPs are reportedly CD16-positive, CD32-positive, CD34-positive, CD38-positive, CD45RA-positive, CD110-negative, CD117-positive, CD123-positive, and SCA1-negative. granulocyte monocyte progenitor cell @@ -11968,7 +11899,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - CFU-GM + colony forming unit granulocyte macrophage ISBN:0721601464 PMCID:PMC2213186 PMCID:PMC548021 @@ -11976,26 +11907,28 @@ MH: sexual subtypes should probably be logically defined based on sexual process - GMP + granulocyte-macrophage progenitor ISBN:0721601464 PMCID:PMC2213186 PMCID:PMC548021 - - colony forming unit granulocyte macrophage + + CFU-GM ISBN:0721601464 PMCID:PMC2213186 PMCID:PMC548021 + - - granulocyte-macrophage progenitor + + GMP ISBN:0721601464 PMCID:PMC2213186 PMCID:PMC548021 + @@ -13670,6 +13603,12 @@ MH: sexual subtypes should probably be logically defined based on sexual process GOC:tfm ISBN:0781735149 + + + + gd T cell + + @@ -16777,16 +16716,12 @@ MH: sexual subtypes should probably be logically defined based on sexual process + - - - - - - - - - + + + + A lymphocyte that has gotten larger after being stimulated by an antigen. 2022-08-17T14:20:01Z @@ -20324,32 +20259,32 @@ MH: sexual subtypes should probably be logically defined based on sexual process - - + + A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures. Wikipedia:Collagen cellular_component GO:0005581 collagen trimer - + - + - + PMID:12382326 - + PMID:12382326 @@ -22468,11 +22403,13 @@ MH: sexual subtypes should probably be logically defined based on sexual process Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538). + https://github.com/geneontology/go-ontology/issues/24680 biological_process accidental cell death necrosis GO:0008219 - This term should not be used for direct annotation. The only exception should be when experimental data (e.g., staining with trypan blue or propidium iodide) show that cell death has occurred, but fail to provide details on death modality (accidental versus programmed). When information is provided on the cell death mechanism, annotations should be made to the appropriate descendant of 'cell death' (such as, but not limited to, GO:0097300 'programmed necrotic cell death' or GO:0006915 'apoptotic process'). Also, if experimental data suggest that a gene product influences cell death indirectly, rather than being involved in the death process directly, consider annotating to a 'regulation' term. + + This term should not be used for direct annotation, it is currently kept in GO as a placeholder for describing cell death phenotypes in uPHENO. When information is provided on a programmed cell death mechanism, annotations should be made to the appropriate descendant of 'cell death' (such as, but not limited to, GO:0097300 'programmed necrotic cell death' or GO:0006915 'apoptotic process'). Unintentional cell death, i.e. cell death caused by injury, ageing, or cell phenotypes observed as a result of a pathological mutation in an essential gene should NOT be annotated using GO terms. cell death @@ -22486,6 +22423,34 @@ MH: sexual subtypes should probably be logically defined based on sexual process + + + + + The multiplication or reproduction of cells, resulting in the expansion of a cell population. + + biological_process + cell proliferation + GO:0008283 + + + + + + + This term was moved out from being a child of 'cellular process' because it is a cell population-level process, and cellular processes are restricted to those processes that involve individual cells. Also note that this term is intended to be used for the proliferation of cells within a multicellular organism, not for the expansion of a population of single-celled organisms. + cell population proliferation + + + + + The multiplication or reproduction of cells, resulting in the expansion of a cell population. + GOC:mah + GOC:mb + + + + @@ -22523,9 +22488,11 @@ MH: sexual subtypes should probably be logically defined based on sexual process + The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. - http://amigo.geneontology.org/amigo/term/GO:0070589 + https://github.com/geneontology/go-ontology/issues/15249 + https://github.com/geneontology/go-ontology/issues/25418 GO:0043284 biopolymer biosynthetic process macromolecule anabolism @@ -22863,9 +22830,10 @@ MH: sexual subtypes should probably be logically defined based on sexual process - - The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, translation and maturation for protein-coding genes. + + The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, as well as translation and maturation for protein-coding genes. https://github.com/geneontology/go-ontology/issues/22557 + https://github.com/geneontology/go-ontology/issues/25419 Wikipedia:Gene_expression biological_process GO:0010467 @@ -22875,7 +22843,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, translation and maturation for protein-coding genes. + The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, as well as translation and maturation for protein-coding genes. GOC:txnOH-2018 PMID:25934543 PMID:31580950 @@ -24050,6 +24018,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process + @@ -27403,6 +27372,29 @@ MH: sexual subtypes should probably be logically defined based on sexual process + + + + + + The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. + cellular anabolism + cellular biosynthesis + cellular formation + cellular synthesis + biological_process + GO:0044249 + cellular biosynthetic process + + + + + The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. + GOC:jl + + + + @@ -31682,6 +31674,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process + A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex but below that of an anatomical system. Or, a substance produced by a cellular organism with granularity above the level of a protein complex. kmv 2019-08-12T18:01:37Z @@ -38809,7 +38802,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + @@ -38845,14 +38838,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process gastrula stage - + - + BILS @@ -39073,7 +39066,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + @@ -39146,7 +39139,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process https://github.com/obophenotype/uberon/issues/661 http://upload.wikimedia.org/wikipedia/commons/0/06/Mouth_illustration-Otis_Archives.jpg - + @@ -39159,7 +39152,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + exceptions in some taxa @@ -39284,15 +39277,15 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + - - + + A fluid that is composed of blood plasma and erythrocytes. This class excludes blood analogues, such as the insect analog of blood. See UBERON:0000179 haemolymphatic fluid. @@ -39334,34 +39327,34 @@ MH: sexual subtypes should probably be logically defined based on sexual process blood - + - + - + - + CL:tm - + https://github.com/obophenotype/uberon/issues/1330 - + Bgee:AN @@ -39665,7 +39658,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + @@ -39707,14 +39700,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process organism substance - + - + this relationship may be too strong and may be weakened in future @@ -40944,7 +40937,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + Primary germ layer that is the outer of the embryo's three germ layers and gives rise to epidermis and neural tissue. Primary germ layer that is the outer of the embryonic germ layers and gives rise to epidermis and neural tissue.[AAO] The Bilateria are triploblastic (with true endoderm, mesoderm, and ectoderm) (...).[well established][VHOG] @@ -40982,14 +40975,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process ectoderm http://upload.wikimedia.org/wikipedia/commons/1/19/Gray32.png - + - + Bgee:AN @@ -41042,7 +41035,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + Primary germ layer that lies remote from the surface of the embryo and gives rise to internal tissues such as gut. The Bilateria are triploblastic (with true endoderm, mesoderm, and ectoderm) (...).[well established][VHOG] endodermal @@ -41079,14 +41072,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process http://upload.wikimedia.org/wikipedia/commons/c/c0/Endoderm2.png http://upload.wikimedia.org/wikipedia/commons/d/df/Gray10.png - + - + Bgee:AN @@ -41131,7 +41124,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + The middle germ layer of the embryo, between the endoderm and ectoderm. Primary germ layer that is the middle of the embryonic germ layers.[AAO] @@ -41176,7 +41169,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process mesoderm http://upload.wikimedia.org/wikipedia/commons/e/e8/Mesoderm.png - + @@ -41189,7 +41182,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + Bgee:AN @@ -41396,7 +41389,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + @@ -41470,14 +41463,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process Taxon notes:" the ascidian tube-like heart lacks chambers....The ascidian heart is formed after metamorphosis as a simple tube-like structure with a single-layered myoepithelium that is continuous with a single-layered pericar- dial wall. It lacks chambers and endocardium.... The innovation of the chambered heart was a key event in vertebrate evolution, because the chambered heart generates one-way blood flow with high pressure, a critical requirement for the efficient blood supply of large-body vertebrates... all extant vertebrates have hearts with two or more chambers (Moorman and Christoffels 2003)" DOI:10.1101/gad.1485706 heart - + - + MA @@ -42133,7 +42126,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + @@ -42186,14 +42179,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process http://upload.wikimedia.org/wikipedia/commons/b/b2/TE-Nervous_system_diagram.svg http://upload.wikimedia.org/wikipedia/commons/b/ba/Nervous_system_diagram.png - + - + Bgee:AN @@ -42281,7 +42274,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the neural tube derivatives: the brain and spinal cord. In invertebrates it includes central ganglia plus nerve cord. Part of the nervous system which includes the brain and spinal cord.[AAO] @@ -42328,7 +42321,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process central nervous system - + @@ -42342,7 +42335,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + Bgee:AN @@ -42836,7 +42829,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + Skeletal element that is composed of bone tissue. @@ -42886,14 +42879,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process bone element - + - + VSAO-modified @@ -43004,7 +42997,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + A tube extending from the mouth to the anus. @@ -43044,14 +43037,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process digestive tract - + - + NCBIBook:NBK10107 @@ -43328,8 +43321,8 @@ MH: sexual subtypes should probably be logically defined based on sexual process - - + + @@ -43342,7 +43335,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + @@ -43401,34 +43394,34 @@ MH: sexual subtypes should probably be logically defined based on sexual process blood vessel http://upload.wikimedia.org/wikipedia/commons/2/29/Circulatory_System_en.svg - + - + - + - + AEO - + EHDAA2 - + GO:0072360 @@ -44151,7 +44144,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + @@ -44185,14 +44178,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process musculoskeletal system - + - + check ctenophore @@ -44321,7 +44314,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + @@ -44362,14 +44355,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process coelemic cavity lumen - + - + definitional @@ -44477,9 +44470,9 @@ MH: sexual subtypes should probably be logically defined based on sexual process - - - + + + @@ -44534,15 +44527,15 @@ MH: sexual subtypes should probably be logically defined based on sexual process notochord http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png - + - + - + @@ -44561,19 +44554,19 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + http://tolweb.org/Chordata/2499 - + ZFA - + EHDAA2 @@ -44658,8 +44651,8 @@ MH: sexual subtypes should probably be logically defined based on sexual process - - + + Somites are spheres of epithelial cells that form sequentially along the anterior-posterior axis of the embryo through mesenchymal to epithelial transition of the presomitic mesoderm. currently classified as an epithelial vesicle, consistent with EHDAA2 and https://github.com/obophenotype/uberon/wiki/The-neural-crest. Consider making 'somitic mesoderm' a separate term and correlate with regionalization processes. Consider moving ZFA term to 'trunk somite' as it is part of the trunk @@ -44705,11 +44698,11 @@ MH: sexual subtypes should probably be logically defined based on sexual process somite http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png - + - + @@ -44722,13 +44715,13 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + GOTAX:0000352 - + ZFA @@ -44841,12 +44834,12 @@ MH: sexual subtypes should probably be logically defined based on sexual process - - - - - - + + + + + + A specialized region of ectoderm found between the neural ectoderm (neural plate) and non-neural ectoderm and composed of highly migratory pluripotent cells that delaminate in early embryonic development from the dorsal neural tube and give rise to an astounding variety of differentiated cell types[MP]. consider including subclasses for pre- and post- migratory (e.g. sheets/paths/streams). @@ -44886,66 +44879,66 @@ MH: sexual subtypes should probably be logically defined based on sexual process http://upload.wikimedia.org/wikipedia/commons/5/5f/Gray644.png https://upload.wikimedia.org/wikipedia/commons/8/8f/Neural_Crest.png - + - + - + - + - + - + - + XAO https://github.com/obophenotype/uberon/wiki/The-neural-crest - + Hall and others restrict NC to vertebrates but we opt for a less restrictive constraint to avoid inconsistencies when areas such as P1 area of pallium in hagfishes inherit cell lineage from telecephalon-contributing NC cells ISBN:0073040584 - + BTO - + PMID:11523831 - + pre migratory https://github.com/obophenotype/uberon/wiki/The-neural-crest - + PMID:11523831 @@ -45133,7 +45126,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + @@ -45191,14 +45184,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process bone marrow http://upload.wikimedia.org/wikipedia/commons/7/74/Gray72-en.svg - + - + FMA MA @@ -45469,14 +45462,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + - + Anatomical system that is involved in the production of hematopoietic cells. Anatomical system that consists of the blood and blood forming tissues.[AAO] @@ -45519,24 +45512,24 @@ MH: sexual subtypes should probably be logically defined based on sexual process hematopoietic system - + - + - + FMA - + definitional @@ -45907,7 +45900,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + Unsegmented field of paraxial mesoderm present posterior to the most recently formed somite pair, from which somites will form. Unsegmented field of paraxial mesoderm present posterior to the most recently formed somite pair, from which somites will form. Kimmel et al, 1995.[TAO] It is reasonable to assume that the proximate invertebrate ancestor of the vertebrates had an amphioxus-like tail bud in its larval stage. This archetypal tail bud would have (...) (3) lacked any component of mesenchyme cells, (4) budded off new mesodermal segments directly, without any intervening zone of presomitic mesoderm (...). Then, early in vertebrate evolution, epithelium-to-mesenchyme interconversions (and the gene networks for effecting them) became prominent features of development. (...) In any case, conspicuous mesenchymal components tended to be added to the vertebrate tail bud itself. In addition, a mesenchymatous presomitic mesoderm (not a part of the tail bud proper) came to intervene between the tail bud and the forming somites.[well established][VHOG] @@ -45932,14 +45925,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process presomitic mesoderm - + - + Bgee:AN @@ -46169,9 +46162,9 @@ MH: sexual subtypes should probably be logically defined based on sexual process - - - + + + A region of embryonic ectodermal cells that lie directly above the notochord. During neurulation, they change shape and produce an infolding of the neural plate (the neural fold) that then seals to form the neural tube[XAO]. The earliest recognizable dorsal ectodermal primordium of the central nervous system present near the end of gastrulation before infolding to form the neural keel; consists of a thickened pseudostratified epithelium[ZFA]. The earliest recognizable dorsal ectodermal primordium of the central nervous system present near the end of gastrulation before infolding to form the neural keel; consists of a thickened pseudostratified epithelium. Kimmel et al, 1995.[TAO] (...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...).[well established][VHOG] @@ -46203,34 +46196,34 @@ MH: sexual subtypes should probably be logically defined based on sexual process neural plate https://upload.wikimedia.org/wikipedia/commons/8/8f/Neural_Crest.png - + - + - + - + GOTAX:0000352 - + Wikipedia - + Bgee:AN @@ -46295,7 +46288,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + The paraxial mesoderm is the mesoderm located bilaterally adjacent to the notochord and neural tube[GO]. Mesoderm lateral to the neural tube and notochord that is divided into cranial and post-cranial portions. The trunk portions further segment into somites.[AAO] Presently, Cephalochordata, Urochordata, and Vertebrata are placed as subphyla of the phylum Chordata, in which the overall organization of embryonic tissues (dorsal hollow nerve cord, ventral digestive tract, axial notochord, and bilateral paraxial mesoderm) is largely conserved. In contrast, the echinoderms and hemichordates are sister groups of the chordates and they lack the notochord and paraxial mesoderm. Thus, the basic mesodermal organization of vertebrates must have appeared first in the common ancestor of the chordates.[well established][VHOG] @@ -46324,7 +46317,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process paraxial mesoderm http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png - + @@ -46337,7 +46330,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + Bgee:AN @@ -46409,7 +46402,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + @@ -46453,7 +46446,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process lateral plate mesoderm http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png - + @@ -46466,7 +46459,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + EHDAA2 VHOG @@ -46550,15 +46543,15 @@ MH: sexual subtypes should probably be logically defined based on sexual process - - + + - + Bilateral groups of cells consisting of three rows: one row of endocardial precursors medially and two rows of myocardical precursors laterally. The two populations fuse at the midline to form the heart rudiment or cone. should probably be merged with heart rudiment. Bilateral groups of cells consisting of three rows: one row of endocardial precursors medially and two rows of myocardical precursors laterally. The two populations fuse at the midline between 21 and 26 somites to form the heart rudiment or cone. Stainier 2001.[TAO] @@ -46578,15 +46571,15 @@ MH: sexual subtypes should probably be logically defined based on sexual process heart primordium - + - + - + @@ -46599,19 +46592,19 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + ZFA - + ZFA - + XAO @@ -46666,8 +46659,8 @@ MH: sexual subtypes should probably be logically defined based on sexual process - - + + Ventral somitic compartment that is a precursor of the axial skeleton[XAO]. Sclerotomes eventually differentiate into the vertebrae and most of the skull. The caudal (posterior) half of one sclerotome fuses with the rostral (anterior) half of the adjacent one to form each vertebra. From their initial location within the somite, the sclerotome cells migrate medially towards the notochord. These cells meet the sclerotome cells from the other side to form the vertebral body. From this vertebral body, sclerotome cells move dorsally and surround the developing spinal cord, forming the vertebral arch[WP]. Skeletogenic portion of somites.[AAO] The vertebrate sclerotome has no equivalent in amphioxus and is a novelty linked with the evolution of the axial skeleton.[well established][VHOG] @@ -46694,11 +46687,11 @@ MH: sexual subtypes should probably be logically defined based on sexual process sclerotome http://upload.wikimedia.org/wikipedia/commons/9/96/Gray65.png - + - + @@ -46717,13 +46710,13 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + VHOG:0000680 - + ZFA @@ -46989,7 +46982,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + The part of the coelom in the embryo between the somatopleuric and splanchnopleuric mesoderm; the principal body cavities of the trunk (thoracic, abdominal, and pelvic) arise from this embryonic part of the coelom. consider merging with coelom. TODO - add spatial relationships to halves of LPM. Note the OG places XAO and ZFA coelem terms here. editor note: TODO check ZFA, which appears to be a structure present in adults (...) I regard it unlikely that coeloms of all bilaterian animals are comparable and evolved very early. Considering all these questions, few convincing characters concerning the evolution of body cavities remain to be named. (...) A segmental coelom appears to have evolved at least two times, in Annelida and in Myomerata (Acrania and Craniota).[well established][VHOG] @@ -47005,14 +46998,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process intraembryonic coelom - + - + Wikipedia @@ -47331,8 +47324,8 @@ MH: sexual subtypes should probably be logically defined based on sexual process - - + + A specific region of the lateral mesoderm that will form the primary beating heart tube. In mammals the primary heart field gives rise to the left ventricle. this term denotes the primary heart field; GO:0003128 denotes the superclass of primary and secondary: specific region of the lateral mesoderm into the area which will form the primary beating heart tube[GO:0003138] XAO:0004185 @@ -47345,24 +47338,24 @@ MH: sexual subtypes should probably be logically defined based on sexual process UBERON:0004140 primary heart field - + - + - + GO:0003128 - + https://orcid.org/0000-0003-3308-6245 @@ -47421,7 +47414,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + An epithelial tube that will give rise to the mature heart. the paired, longitudinal, endothelial-lined channels formed from the cardiogenic mesoderm in embryonic development; angiogenic cell clusters (aka angioblastic cords) located in a horse-shoe shape configuration in the cardiogenic plate coalesce to form the right and left endocardial heart tubes which then fuse in cephalo-caudal direction to form a single primitive heart tube. AAO:0010411 @@ -47441,14 +47434,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process heart tube - + - + ZFA-modified @@ -48063,7 +48056,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + A specialized form of connective tissue in which the extracellular matrix is firm, providing the tissue with resilience, and/or mineralized and that functions in mechanical and structural support.[VSAO]. A specialized form of connective tissue in which the extracellular matrix is firm, providing the tissue with resilience, and/or mineralized and that functions in mechanical and structural support.[VSAO] EMAPA:37744 @@ -48077,7 +48070,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process Four classes of mineralized tissues are found in vertebrates: bone, cartilage, dentine, and enamel. We think of cartilage and bone as skeletal tissues and of enamel and dentine as dental tissues, but enamel and dentine arose evolutionarily together with bone as skeletal tissues in the dermal skeleton (exoskeleton) of early vertebrates. Scales and teeth of sharks are examples of dermal skeletal elements that are still composed of the three ancient components-enamel, dentine, and bone. Cartilage, on the other hand, provided the basis for the second vertebrate skeletal system, the endoskeleton (Smith and Hall, 1990; Hall, 1998a,b). some invertebrate skeletal tissues have surprisingly bone-like features. Examples include chondrocytes interconnected by cell processes in cephalopod cartilages (Cole and Hall, 2004a,b), and the calcium phosphate layer in the shells of brachiopods (Rodland et al., 2003). However, neither bone nor mineralized cartilage have been found in invertebrates. Editors notes: TODO - develops_from skeletal tissue - + @@ -48090,7 +48083,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + 2012-08-14 VSAO:0000015 VSAO @@ -48129,7 +48122,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + Organ consisting of skeletal tissue. Encompasses whole bones, fused bones, cartilaginious elements, teeth, dermal denticles. Organ entity that is typically involved in mechanical support and may have different skeletal tissue compositions at different stages.[VSAO] Organ entity that may have different tissue compositions at different stages and is typically involved in mechanical support.[TAO] @@ -48145,14 +48138,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process skeletal element - + - + VSAO @@ -48197,7 +48190,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + @@ -48236,14 +48229,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process UBERON:0004770 articular system - + - + FMA @@ -49001,7 +48994,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + Mesenchyme that is part of a developing trunk. EFO:0003485 EHDAA2:0002092 @@ -49017,14 +49010,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process trunk mesenchyme - + - + EHDAA2 @@ -49135,7 +49128,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + Multi-tissue structure that arises from the heart rudiment and will become the heart tube. EHDAA2:0001512 EHDAA:424 @@ -49153,14 +49146,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process primitive heart tube - + - + ZFA @@ -49328,7 +49321,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + A delimited region of dense mesenchyme within looser mesenchyme. AEO:0000148 EHDAA2_RETIRED:0003148 @@ -49338,7 +49331,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process UBERON:0005856 developing mesenchymal condensation - + @@ -49357,7 +49350,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + AEO-modified-relation @@ -49462,7 +49455,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + The notochordal plate is the dorsal part of the notochordal process when the ventral portion breaks down. It is continuous laterally with the endoderm that composes the roof of the primitive foregut and is in contact dorsally with the neural tube. The folding off of the notochordal plate gives rise to the notochord. TODO - check ordering; awaiting confirmation from JB The notochordal plate is the dorsal part of the notochordal process when the ventral portion breaks down. It is continuous laterally with the endoderm that composes the roof of the primitive foregut and is in contact dorsally with the neural tube. The folding off of the notochordal plate gives rise to the notochord. [Carson_JL, Dehart_DB, Developmental_Dynamics_(1994)_201:_260-278, Gesteland_K_and_Schoenwolf_GC, Inagaki_T, Morphogenesis_of_the_murine_node_and_notochordal_plate, The_prechordal_plate, Vrablic_T, see_Mueller_F_and_O'Rahilly_R, the_rostral_end_of_the_notochord_and_nearby_median_features_in_staged_human_embryos._Cells_Tissues_Organs_(2003)_173:_1-20_and_Sulik_K][VHOG] @@ -49477,7 +49470,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process notochordal plate - + @@ -49490,7 +49483,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + EHDAA2 @@ -49527,7 +49520,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + A midline cellular cord formed from the migration of mesenchymal cells from the primitive knot. EHDAA2:0001279 EHDAA:224 @@ -49544,14 +49537,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process The notochordal process grows cranially until it reaches the prechordal plate, the future site of the mouth. In this area the ectoderm is attached directly to the endoderm without intervening mesoderm. This area is known as the oropharyngeal membrane, and it will break down to become the mouth. At the other end of the primitive streak the ectoderm is also fused directly to the endoderm; this is known as the cloacal membrane (proctodeum), or primordial anus. notochordal process - + - + EHDAA2 @@ -50294,7 +50287,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + A hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood or analogs[GO,modified]. note we reserve the subclass 'heart' from the vertebrate multi-chambered heart. 'The first heart-like organ is believed to have appeared 500my ago in an ancestral bilaterian'. Amniotes: four-chambered heart. Amphibians: two atria, one ventricle, pulmonary; fish: single atrium and ventricle; amphioxus: tubular, non-striated, closed, unidirectional; ascidians: tubular, striated, open, bidirectional; arthropods: tubular, open; C elegans: contractile pharynx; Cnideria: striated muscle cells associated with gastrodermis SPD:0000130 @@ -50309,14 +50302,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process Gene notes: Bmp, Nkx, Gata primary circulatory organ - + - + GO uses blood circulation generically to include the haemolymphatic fluid of arthropods @@ -50406,7 +50399,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + @@ -50423,14 +50416,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process presumptive segmental plate - + - + https://github.com/obophenotype/uberon/wiki/The-neural-crest EDHAA2 @@ -50529,7 +50522,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + @@ -50555,7 +50548,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process presumptive paraxial mesoderm - + @@ -50571,7 +50564,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + https://github.com/obophenotype/uberon/issues/1277 @@ -50647,7 +50640,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + Mesenchyme with little extracellular matrix. AEO:0000146 EHDAA2:0003146 @@ -50655,7 +50648,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process UBERON:0007524 dense mesenchyme tissue - + @@ -50668,7 +50661,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + AEO @@ -50765,7 +50758,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + Anatomical system that consists of all blood and lymph vessels. consider merging with vasculature The cardiovascular and lymphatic systems, collectively[ncithesaurus:Vascular_System]. @@ -50782,14 +50775,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process vascular system - + - + MA @@ -50922,7 +50915,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + @@ -50939,14 +50932,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process UBERON:0009142 entire embryonic mesenchyme - + - + EHDAA2 @@ -51002,7 +50995,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + EHDAA2:0002094 trunk and cervical paraxial mesenchyme uberon @@ -51010,14 +51003,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process UBERON:0009618 trunk paraxial mesoderm - + - + EHDAA2 @@ -51039,7 +51032,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + EFO:0003704 TAO:0005041 ZFA:0005041 @@ -51049,14 +51042,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process anterior lateral plate mesoderm - + - + ZFA @@ -51190,7 +51183,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + @@ -51210,14 +51203,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process UBERON:0010210 blood clot - + - + BTO @@ -51339,8 +51332,8 @@ MH: sexual subtypes should probably be logically defined based on sexual process - - + + Anatomical cluster consisting of the skeletal elements (i.e. bone elements, cartilage elements, cartilage condensations) that are part of an individual subdivision of the organism. Excludes joints. Anatomical cluster consisting of the skeletal elements that are part of the skeleton.[VSAO] FMA:23879 @@ -51353,11 +51346,11 @@ MH: sexual subtypes should probably be logically defined based on sexual process subdivision of skeleton - + - + @@ -51370,13 +51363,13 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + UBERONREF:0000003 - + VSAO @@ -51453,7 +51446,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + Subdivision of the skeletal system which consists of the postcranial axial skeleton plus associated joints. axial skeletal system FMA:302077 @@ -51463,7 +51456,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process postcranial axial skeletal system http://purl.obolibrary.org/obo/uberon/docs/The-axial-skeleton - + @@ -51476,7 +51469,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + cjm @@ -51741,7 +51734,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + @@ -51763,7 +51756,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process UBERON:0012429 hematopoietic tissue - + @@ -51776,7 +51769,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + defitional @@ -52346,7 +52339,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + @@ -52369,7 +52362,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process UBERON:0016887 entire extraembryonic component - + @@ -52382,7 +52375,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + AEO @@ -52607,196 +52600,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process - - - - - - - - - example to be eventually removed - example to be eventually removed - - - - - - - - failed exploratory term - The term was used in an attempt to structure part of the ontology but in retrospect failed to do a good job - Person:Alan Ruttenberg - failed exploratory term - - - - - - - - metadata complete - Class has all its metadata, but is either not guaranteed to be in its final location in the asserted IS_A hierarchy or refers to another class that is not complete. - metadata complete - - - - - - - - organizational term - Term created to ease viewing/sort terms for development purpose, and will not be included in a release - organizational term - - - - - - - - ready for release - Class has undergone final review, is ready for use, and will be included in the next release. Any class lacking "ready_for_release" should be considered likely to change place in hierarchy, have its definition refined, or be obsoleted in the next release. Those classes deemed "ready_for_release" will also derived from a chain of ancestor classes that are also "ready_for_release." - ready for release - - - - - - - - metadata incomplete - Class is being worked on; however, the metadata (including definition) are not complete or sufficiently clear to the branch editors. - metadata incomplete - - - - - - - - uncurated - Nothing done yet beyond assigning a unique class ID and proposing a preferred term. - uncurated - - - - - - - - pending final vetting - All definitions, placement in the asserted IS_A hierarchy and required minimal metadata are complete. The class is awaiting a final review by someone other than the term editor. - pending final vetting - - - - - - - - placeholder removed - placeholder removed - - - - - - - - terms merged - An editor note should explain what were the merged terms and the reason for the merge. - terms merged - - - - - - - - term imported - This is to be used when the original term has been replaced by a term imported from an other ontology. An editor note should indicate what is the URI of the new term to use. - term imported - - - - - - - - term split - This is to be used when a term has been split in two or more new terms. An editor note should indicate the reason for the split and indicate the URIs of the new terms created. - term split - - - - - - - - universal - Hard to give a definition for. Intuitively a "natural kind" rather than a collection of any old things, which a class is able to be, formally. At the meta level, universals are defined as positives, are disjoint with their siblings, have single asserted parents. - Alan Ruttenberg - A Formal Theory of Substances, Qualities, and Universals, http://ontology.buffalo.edu/bfo/SQU.pdf - universal - - - - - - - - defined class - A defined class is a class that is defined by a set of logically necessary and sufficient conditions but is not a universal - "definitions", in some readings, always are given by necessary and sufficient conditions. So one must be careful (and this is difficult sometimes) to distinguish between defined classes and universal. - Alan Ruttenberg - defined class - - - - - - - - named class expression - A named class expression is a logical expression that is given a name. The name can be used in place of the expression. - named class expressions are used in order to have more concise logical definition but their extensions may not be interesting classes on their own. In languages such as OWL, with no provisions for macros, these show up as actuall classes. Tools may with to not show them as such, and to replace uses of the macros with their expansions - Alan Ruttenberg - named class expression - - - - - - - - to be replaced with external ontology term - Terms with this status should eventually replaced with a term from another ontology. - Alan Ruttenberg - group:OBI - to be replaced with external ontology term - - - - - - - - requires discussion - A term that is metadata complete, has been reviewed, and problems have been identified that require discussion before release. Such a term requires editor note(s) to identify the outstanding issues. - Alan Ruttenberg - group:OBI - requires discussion - - - - - + + symbol + @@ -75,34 +77,7 @@ - definition - - The official definition, explaining the meaning of a class or property. Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions. - 2012-04-05: -Barry Smith - -The official OBI definition, explaining the meaning of a class or property: 'Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions' is terrible. - -Can you fix to something like: - -A statement of necessary and sufficient conditions explaining the meaning of an expression referring to a class or property. - -Alan Ruttenberg - -Your proposed definition is a reasonable candidate, except that it is very common that necessary and sufficient conditions are not given. Mostly they are necessary, occasionally they are necessary and sufficient or just sufficient. Often they use terms that are not themselves defined and so they effectively can't be evaluated by those criteria. - -On the specifics of the proposed definition: - -We don't have definitions of 'meaning' or 'expression' or 'property'. For 'reference' in the intended sense I think we use the term 'denotation'. For 'expression', I think we you mean symbol, or identifier. For 'meaning' it differs for class and property. For class we want documentation that let's the intended reader determine whether an entity is instance of the class, or not. For property we want documentation that let's the intended reader determine, given a pair of potential relata, whether the assertion that the relation holds is true. The 'intended reader' part suggests that we also specify who, we expect, would be able to understand the definition, and also generalizes over human and computer reader to include textual and logical definition. - -Personally, I am more comfortable weakening definition to documentation, with instructions as to what is desirable. - -We also have the outstanding issue of how to aim different definitions to different audiences. A clinical audience reading chebi wants a different sort of definition documentation/definition from a chemistry trained audience, and similarly there is a need for a definition that is adequate for an ontologist to work with. - PERSON:Daniel Schober - GROUP:OBI:<http://purl.obolibrary.org/obo/obi> - definition - definition @@ -110,19 +85,12 @@ We also have the outstanding issue of how to aim different definitions to differ - editor note - - An administrative note intended for its editor. It may not be included in the publication version of the ontology, so it should contain nothing necessary for end users to understand the ontology. - PERSON:Daniel Schober - GROUP:OBI:<http://purl.obofoundry.org/obo/obi> IAO:0000116 uberon editor_note true editor_note - editor note - editor note @@ -147,13 +115,7 @@ We also have the outstanding issue of how to aim different definitions to differ - - has obsolescence reason - Relates an annotation property to an obsolescence reason. The values of obsolescence reasons come from a list of predefined terms, instances of the class obsolescence reason specification. - PERSON:Alan Ruttenberg - PERSON:Melanie Courtot - has obsolescence reason - + @@ -166,12 +128,6 @@ We also have the outstanding issue of how to aim different definitions to differ - term tracker item - the URI for an OBI Terms ticket at sourceforge, such as https://sourceforge.net/p/obi/obi-terms/772/ - - An IRI or similar locator for a request or discussion of an ontology term. - Person: Jie Zheng, Chris Stoeckert, Alan Ruttenberg - Person: Jie Zheng, Chris Stoeckert, Alan Ruttenberg IAO:0000233 external uberon @@ -179,9 +135,7 @@ We also have the outstanding issue of how to aim different definitions to differ true true term_tracker_item - The 'tracker item' can associate a tracker with a specific ontology term. term tracker item - term tracker item @@ -189,15 +143,7 @@ We also have the outstanding issue of how to aim different definitions to differ - expand expression to - ObjectProperty: RO_0002104 -Label: has plasma membrane part -Annotations: IAO_0000424 "http://purl.obolibrary.org/obo/BFO_0000051 some (http://purl.org/obo/owl/GO#GO_0005886 and http://purl.obolibrary.org/obo/BFO_0000051 some ?Y)" - - A macro expansion tag applied to an object property (or possibly a data property) which can be used by a macro-expansion engine to generate more complex expressions from simpler ones - Chris Mungall expand expression to - expand expression to @@ -229,16 +175,14 @@ Annotations: IAO_0000424 "http://purl.obolibrary.org/obo/BFO_0000051 some ( - has ontology root term - Ontology annotation property. Relates an ontology to a term that is a designated root term of the ontology. Display tools like OLS can use terms annotated with this property as the starting point for rendering the ontology class hierarchy. There can be more than one root. - Nicolas Matentzoglu IAO:0000700 + external uberon has_ontology_root_term + true true has_ontology_root_term has ontology root term - has ontology root term preferred_root @@ -253,14 +197,7 @@ Annotations: IAO_0000424 "http://purl.obolibrary.org/obo/BFO_0000051 some ( - term replaced by - - Use on obsolete terms, relating the term to another term that can be used as a substitute - Person:Alan Ruttenberg - Person:Alan Ruttenberg - Add as annotation triples in the granting ontology term replaced by - term replaced by @@ -1433,12 +1370,6 @@ WHERE { - - - - - - @@ -1503,6 +1434,12 @@ WHERE { + + + + + + @@ -2070,7 +2007,7 @@ A continuant cannot have an occurrent as part: use 'participates in'. An example is: translation preceded_by transcription; aging preceded_by development (not however death preceded_by aging). Where derives_from links classes of continuants, preceded_by links classes of processes. Clearly, however, these two relations are not independent of each other. Thus if cells of type C1 derive_from cells of type C, then any cell division involving an instance of C1 in a given lineage is preceded_by cellular processes involving an instance of C. The assertion P preceded_by P1 tells us something about Ps in general: that is, it tells us something about what happened earlier, given what we know about what happened later. Thus it does not provide information pointing in the opposite direction, concerning instances of P1 in general; that is, that each is such as to be succeeded by some instance of P. Note that an assertion to the effect that P preceded_by P1 is rather weak; it tells us little about the relations between the underlying instances in virtue of which the preceded_by relation obtains. Typically we will be interested in stronger relations, for example in the relation immediately_preceded_by, or in relations which combine preceded_by with a condition to the effect that the corresponding instances of P and P1 share participants, or that their participants are connected by relations of derivation, or (as a first step along the road to a treatment of causality) that the one process in some way affects (for example, initiates or regulates) the other. is preceded by preceded_by - http://www.obofoundry.org/ro/#OBO_REL:preceded_by + http://www.obofoundry.org/ro/#OBO_REL:preceded_by BFO:0000062 external uberon @@ -2502,24 +2439,6 @@ A continuant cannot have an occurrent as part: use 'participates in'. - - - - This document is about information artifacts and their representations - - A (currently) primitive relation that relates an information artifact to an entity. - 7/6/2009 Alan Ruttenberg. Following discussion with Jonathan Rees, and introduction of "mentions" relation. Weaken the is_about relationship to be primitive. - -We will try to build it back up by elaborating the various subproperties that are more precisely defined. - -Some currently missing phenomena that should be considered "about" are predications - "The only person who knows the answer is sitting beside me" , Allegory, Satire, and other literary forms that can be topical without explicitly mentioning the topic. - person:Alan Ruttenberg - Smith, Ceusters, Ruttenberg, 2000 years of philosophy - is about - - - - @@ -2600,7 +2519,7 @@ Some currently missing phenomena that should be considered "about" are a relation between a process and a continuant, in which the continuant is somehow involved in the process Has_participant is a primitive instance-level relation between a process, a continuant, and a time at which the continuant participates in some way in the process. The relation obtains, for example, when this particular process of oxygen exchange across this particular alveolar membrane has_participant this particular sample of hemoglobin at this particular time. has_participant - http://www.obofoundry.org/ro/#OBO_REL:has_participant + http://www.obofoundry.org/ro/#OBO_REL:has_participant RO:0000057 external has_participant @@ -2783,43 +2702,18 @@ Some currently missing phenomena that should be considered "about" are - - - - - - - - - - - contained in - Containment is location not involving parthood, and arises only where some immaterial continuant is involved. - Containment obtains in each case between material and immaterial continuants, for instance: lung contained_in thoracic cavity; bladder contained_in pelvic cavity. Hence containment is not a transitive relation. If c part_of c1 at t then we have also, by our definition and by the axioms of mereology applied to spatial regions, c located_in c1 at t. Thus, many examples of instance-level location relations for continuants are in fact cases of instance-level parthood. For material continuants location and parthood coincide. Containment is location not involving parthood, and arises only where some immaterial continuant is involved. To understand this relation, we first define overlap for continuants as follows: c1 overlap c2 at t =def for some c, c part_of c1 at t and c part_of c2 at t. The containment relation on the instance level can then be defined (see definition): - Intended meaning: -domain: material entity -range: spatial region or site (immaterial continuant) - - contained_in - - - contained in - - - - contains - RO:0001019 uberon contains - contains contains - contains + obsolete contains + + true @@ -2842,7 +2736,7 @@ range: spatial region or site (immaterial continuant) Most location relations will only hold at certain times, but this is difficult to specify in OWL. See http://purl.obolibrary.org/obo/ro/docs/temporal-semantics/ located_in - http://www.obofoundry.org/ro/#OBO_REL:located_in + http://www.obofoundry.org/ro/#OBO_REL:located_in RO:0001025 uberon located_in @@ -6939,16 +6833,6 @@ For example, A and B may be gene products and binding of B by A positively regul - - - - A relationship that holds between two entities, where the entities exhibit a statistical dependence relationship. The entities may be statistical variables, or they may be other kinds of entities such as diseases, chemical entities or processes. - Groups both positive and negative correlation - correlated with - - - - @@ -7478,27 +7362,13 @@ For example, A and B may be gene products and binding of B by A positively regul A diagnostic testing device utilizes a specimen means that the diagnostic testing device is capable of an assay, and this assay a specimen as its input. See github ticket https://github.com/oborel/obo-relations/issues/497 - 2021-11-08T12:00:00Z + 2021-11-08T12:00:00Z utilizes device utilizes material - - - - - - - A relation between entities in which one increases or decreases as the other does the same. - directly correlated with - - positively correlated with - - - - @@ -8173,7 +8043,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + @@ -8189,7 +8059,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process multicellular anatomical structure - + @@ -8201,7 +8071,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + There is a cost to burying this in PATO. We lose that we could relax the cardinality assertion to subClassOf has_part some cell. I'm sure having this axiom inherited would come in handy. DOS @@ -8711,9 +8581,9 @@ MH: sexual subtypes should probably be logically defined based on sexual process FMA:86475 MESH:D006412 VHOG:0001485 - HSC blood forming stem cell hemopoietic stem cell + HSC colony forming unit hematopoietic @@ -8730,6 +8600,12 @@ MH: sexual subtypes should probably be logically defined based on sexual process PMID:19022770 http://en.wikipedia.org/wiki/Hematopoietic_stem_cell + + + + HSC + + @@ -8768,6 +8644,18 @@ MH: sexual subtypes should probably be logically defined based on sexual process GOC:add ISBN:0721601464 + + + + BFU-E + + + + + + CFU-E + + @@ -8822,10 +8710,10 @@ MH: sexual subtypes should probably be logically defined based on sexual process A progenitor cell committed to myeloid lineage, including the megakaryocyte and erythroid lineages. BTO:0004730 - CMP common myeloid precursor CFU-GEMM CFU-S + CMP colony forming unit granulocyte, erythrocyte, macrophage, and megakaryocyte multipotential myeloid stem cell myeloid stem cell @@ -8850,21 +8738,24 @@ MH: sexual subtypes should probably be logically defined based on sexual process - - CMP + + CFU-GEMM ISBN:0878932437 + - CFU-GEMM + CFU-S ISBN:0878932437 + - CFU-S + CMP ISBN:0878932437 + @@ -9077,6 +8968,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process epithelial cell + https://www.swissbiopics.org/api/image/Epithelial_cells.svg @@ -9535,7 +9427,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process An hexagonal, flattened, mitochondria-rich endothelial cell that forms a monolayer on the posterior surface of the cornea (the corneal endothelium). Corneal endothelial cells are derived from the neural crest and are responsible for keeping the cornea transparent by maintaining the tissue in a semi-dry state through the action of their ionic pumps and tight junction barrier. GOC:tfm - MESH:A09.371.060.067.31 PMID:21976958 PMID:23284695 PMID:34741068 @@ -9571,10 +9462,10 @@ MH: sexual subtypes should probably be logically defined based on sexual process BTO:0002625 BTO:0003298 FMA:70546 - BMSC bone marrow stromal cells colony-forming unit-fibroblast marrow stromal cells + BMSC CFU-F MSC mesenchymal precursor cell @@ -9613,11 +9504,24 @@ MH: sexual subtypes should probably be logically defined based on sexual process marrow stromal cells PMID:11378515 + + + + BMSC + + + + + + CFU-F + + MSC PMID:11378515 + @@ -9807,6 +9711,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process muscle fiber myocyte muscle cell + https://www.swissbiopics.org/api/image/Muscle_cells.svg @@ -9929,6 +9834,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process CALOHA:TS-0868 FMA:86740 photoreceptor cell + https://www.swissbiopics.org/api/image/Photoreceptor_cell.svg @@ -10330,7 +10236,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process A cell derived from the specialized ectoderm flanking each side of the embryonic neural plate, which after the closure of the neural tube, forms masses of cells that migrate out from the dorsal aspect of the neural tube to spread throughout the body. - MESH:A16.254.600 + doi:10.1016/j.stem.2015.02.017 @@ -10695,6 +10601,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process These cells are also reportedly CD4-negative and CD200-positive. They are also capable of producing CD40L and IFN-gamma. neuron + https://www.swissbiopics.org/api/image/Neuron_cells.svg @@ -10925,7 +10832,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process An immature, nucleated erythrocyte occupying the stage of erythropoeisis that follows formation of erythroid progenitor cells. This cell is CD71-positive, has both a nucleus and a nucleolus, and lacks hematopoeitic lineage markers. ISBN:0721601464 - MESH:A11.118.290.350.200 PMID:1638021 @@ -10962,6 +10868,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process metazoan cell animal cell + https://www.swissbiopics.org/api/image/Animal_cells.svg @@ -15322,32 +15229,32 @@ plexiform layer. - - + + A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures. Wikipedia:Collagen cellular_component GO:0005581 collagen trimer - + - + - + PMID:12382326 - + PMID:12382326 @@ -17005,11 +16912,13 @@ plexiform layer. Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538). + https://github.com/geneontology/go-ontology/issues/24680 biological_process accidental cell death necrosis GO:0008219 - This term should not be used for direct annotation. The only exception should be when experimental data (e.g., staining with trypan blue or propidium iodide) show that cell death has occurred, but fail to provide details on death modality (accidental versus programmed). When information is provided on the cell death mechanism, annotations should be made to the appropriate descendant of 'cell death' (such as, but not limited to, GO:0097300 'programmed necrotic cell death' or GO:0006915 'apoptotic process'). Also, if experimental data suggest that a gene product influences cell death indirectly, rather than being involved in the death process directly, consider annotating to a 'regulation' term. + + This term should not be used for direct annotation, it is currently kept in GO as a placeholder for describing cell death phenotypes in uPHENO. When information is provided on a programmed cell death mechanism, annotations should be made to the appropriate descendant of 'cell death' (such as, but not limited to, GO:0097300 'programmed necrotic cell death' or GO:0006915 'apoptotic process'). Unintentional cell death, i.e. cell death caused by injury, ageing, or cell phenotypes observed as a result of a pathological mutation in an essential gene should NOT be annotated using GO terms. cell death @@ -17023,6 +16932,34 @@ plexiform layer. + + + + + The multiplication or reproduction of cells, resulting in the expansion of a cell population. + + biological_process + cell proliferation + GO:0008283 + + + + + + + This term was moved out from being a child of 'cellular process' because it is a cell population-level process, and cellular processes are restricted to those processes that involve individual cells. Also note that this term is intended to be used for the proliferation of cells within a multicellular organism, not for the expansion of a population of single-celled organisms. + cell population proliferation + + + + + The multiplication or reproduction of cells, resulting in the expansion of a cell population. + GOC:mah + GOC:mb + + + + @@ -17060,9 +16997,11 @@ plexiform layer. + The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. - http://amigo.geneontology.org/amigo/term/GO:0070589 + https://github.com/geneontology/go-ontology/issues/15249 + https://github.com/geneontology/go-ontology/issues/25418 GO:0043284 biopolymer biosynthetic process macromolecule anabolism @@ -17482,9 +17421,10 @@ plexiform layer. - - The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, translation and maturation for protein-coding genes. + + The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, as well as translation and maturation for protein-coding genes. https://github.com/geneontology/go-ontology/issues/22557 + https://github.com/geneontology/go-ontology/issues/25419 Wikipedia:Gene_expression biological_process GO:0010467 @@ -17494,7 +17434,7 @@ plexiform layer. - The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, translation and maturation for protein-coding genes. + The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, as well as translation and maturation for protein-coding genes. GOC:txnOH-2018 PMID:25934543 PMID:31580950 @@ -18357,6 +18297,7 @@ plexiform layer. + @@ -20499,6 +20440,29 @@ plexiform layer. + + + + + + The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. + cellular anabolism + cellular biosynthesis + cellular formation + cellular synthesis + biological_process + GO:0044249 + cellular biosynthetic process + + + + + The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. + GOC:jl + + + + @@ -23359,8 +23323,8 @@ plexiform layer. + - @@ -23374,8 +23338,8 @@ plexiform layer. The part of synaptic transmission occurring in the post-synapse: a signal transduction pathway consisting of neurotransmitter receptor activation and its effects on postsynaptic membrane potential and the ionic composition of the postsynaptic cytosol. + postsynaptic process involved in chemical synaptic transmission biological_process - postsynaptic process involved in chemical synaptic transmission GO:0099565 chemical synaptic transmission, postsynaptic @@ -23388,7 +23352,7 @@ plexiform layer. - + postsynaptic process involved in chemical synaptic transmission @@ -23454,6 +23418,7 @@ plexiform layer. + A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex but below that of an anatomical system. Or, a substance produced by a cellular organism with granularity above the level of a protein complex. kmv 2019-08-12T18:01:37Z @@ -23904,94 +23869,6 @@ plexiform layer. - - - - - - - - - - - - - - - - - - - - - - Any cell surface receptor signaling pathway that is involved in cell-cell signaling. - dos - 2016-04-06T16:59:57Z - cell surface receptor linked signal transduction involved in cell-cell signaling - cell surface receptor linked signal transduction involved in cell-cell signalling - cell surface receptor linked signaling pathway involved in cell-cell signaling - cell surface receptor linked signaling pathway involved in cell-cell signalling - cell surface receptor linked signalling pathway involved in cell-cell signaling - cell surface receptor linked signalling pathway involved in cell-cell signalling - cell surface receptor signaling pathway involved in cell-cell signalling - biological_process - GO:1905114 - cell surface receptor signaling pathway involved in cell-cell signaling - - - - - Any cell surface receptor signaling pathway that is involved in cell-cell signaling. - GOC:TermGenie - GO_REF:0000060 - ISBN:0-7167-3051-0 - - - - - cell surface receptor linked signal transduction involved in cell-cell signaling - GOC:TermGenie - - - - - cell surface receptor linked signal transduction involved in cell-cell signalling - GOC:TermGenie - - - - - cell surface receptor linked signaling pathway involved in cell-cell signaling - GOC:TermGenie - - - - - cell surface receptor linked signaling pathway involved in cell-cell signalling - GOC:TermGenie - - - - - cell surface receptor linked signalling pathway involved in cell-cell signaling - GOC:TermGenie - - - - - cell surface receptor linked signalling pathway involved in cell-cell signalling - GOC:TermGenie - - - - - cell surface receptor signaling pathway involved in cell-cell signalling - GOC:TermGenie - - - - @@ -27406,7 +27283,7 @@ plexiform layer. - + @@ -27447,14 +27324,14 @@ plexiform layer. camera-type eye - + - + definitional @@ -28555,7 +28432,7 @@ plexiform layer. - + The surface (external) layer of ectoderm which begins to proliferate shortly after separation from the neuroectoderm. merge with non-neural. In vertebrates, the ectoderm has three parts: external ectoderm (also known as surface ectoderm), the neurectoderm (neural crest, and neural tube) @@ -28580,7 +28457,7 @@ plexiform layer. external ectoderm http://upload.wikimedia.org/wikipedia/commons/1/1d/Ectoderm.png - + @@ -28593,7 +28470,7 @@ plexiform layer. - + EHDAA2 @@ -28962,7 +28839,7 @@ plexiform layer. - + @@ -28998,14 +28875,14 @@ plexiform layer. gastrula stage - + - + BILS @@ -29271,7 +29148,7 @@ plexiform layer. - + @@ -29344,7 +29221,7 @@ plexiform layer. https://github.com/obophenotype/uberon/issues/661 http://upload.wikimedia.org/wikipedia/commons/0/06/Mouth_illustration-Otis_Archives.jpg - + @@ -29357,7 +29234,7 @@ plexiform layer. - + exceptions in some taxa @@ -29482,15 +29359,15 @@ plexiform layer. - + - - + + A fluid that is composed of blood plasma and erythrocytes. This class excludes blood analogues, such as the insect analog of blood. See UBERON:0000179 haemolymphatic fluid. @@ -29532,34 +29409,34 @@ plexiform layer. blood - + - + - + - + CL:tm - + https://github.com/obophenotype/uberon/issues/1330 - + Bgee:AN @@ -29863,7 +29740,7 @@ plexiform layer. - + @@ -29905,14 +29782,14 @@ plexiform layer. organism substance - + - + this relationship may be too strong and may be weakened in future @@ -31245,7 +31122,7 @@ plexiform layer. - + Primary germ layer that is the outer of the embryo's three germ layers and gives rise to epidermis and neural tissue. Primary germ layer that is the outer of the embryonic germ layers and gives rise to epidermis and neural tissue.[AAO] The Bilateria are triploblastic (with true endoderm, mesoderm, and ectoderm) (...).[well established][VHOG] @@ -31283,14 +31160,14 @@ plexiform layer. ectoderm http://upload.wikimedia.org/wikipedia/commons/1/19/Gray32.png - + - + Bgee:AN @@ -31343,7 +31220,7 @@ plexiform layer. - + Primary germ layer that lies remote from the surface of the embryo and gives rise to internal tissues such as gut. The Bilateria are triploblastic (with true endoderm, mesoderm, and ectoderm) (...).[well established][VHOG] endodermal @@ -31380,14 +31257,14 @@ plexiform layer. http://upload.wikimedia.org/wikipedia/commons/c/c0/Endoderm2.png http://upload.wikimedia.org/wikipedia/commons/d/df/Gray10.png - + - + Bgee:AN @@ -31432,7 +31309,7 @@ plexiform layer. - + The middle germ layer of the embryo, between the endoderm and ectoderm. Primary germ layer that is the middle of the embryonic germ layers.[AAO] @@ -31477,7 +31354,7 @@ plexiform layer. mesoderm http://upload.wikimedia.org/wikipedia/commons/e/e8/Mesoderm.png - + @@ -31490,7 +31367,7 @@ plexiform layer. - + Bgee:AN @@ -31712,7 +31589,7 @@ plexiform layer. - + @@ -31778,14 +31655,14 @@ plexiform layer. cranial nerve II - + - + EHDAA2 @@ -31929,7 +31806,7 @@ plexiform layer. - + @@ -32003,14 +31880,14 @@ plexiform layer. Taxon notes:" the ascidian tube-like heart lacks chambers....The ascidian heart is formed after metamorphosis as a simple tube-like structure with a single-layered myoepithelium that is continuous with a single-layered pericar- dial wall. It lacks chambers and endocardium.... The innovation of the chambered heart was a key event in vertebrate evolution, because the chambered heart generates one-way blood flow with high pressure, a critical requirement for the efficient blood supply of large-body vertebrates... all extant vertebrates have hearts with two or more chambers (Moorman and Christoffels 2003)" DOI:10.1101/gad.1485706 heart - + - + MA @@ -32088,7 +31965,7 @@ plexiform layer. - + @@ -32113,7 +31990,7 @@ plexiform layer. - + The brain is the center of the nervous system in all vertebrate, and most invertebrate, animals. Some primitive animals such as jellyfish and starfish have a decentralized nervous system without a brain, while sponges lack any nervous system at all. In vertebrates, the brain is located in the head, protected by the skull and close to the primary sensory apparatus of vision, hearing, balance, taste, and smell[WP]. requires review for applicability to invertebrate structures, e.g. synganglion @@ -32174,11 +32051,11 @@ plexiform layer. brain - + - + @@ -32191,13 +32068,13 @@ plexiform layer. - + FMA - + Bgee:AN @@ -32498,9 +32375,9 @@ plexiform layer. - - - + + + @@ -32525,7 +32402,7 @@ plexiform layer. - + @@ -32581,44 +32458,44 @@ plexiform layer. cornea http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg - + - + - + - + - + MA - + MA - + FMA-isa - + definitional @@ -32807,10 +32684,10 @@ plexiform layer. - - - - + + + + The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates. @@ -32861,44 +32738,44 @@ plexiform layer. retina http://upload.wikimedia.org/wikipedia/commons/e/ed/Human_eye_cross-sectional_view_grayscale.png - + - + - + - + - + FMA - + FMA - + FMA - + EHDAA2 @@ -32972,8 +32849,8 @@ plexiform layer. - - + + @@ -33009,24 +32886,24 @@ plexiform layer. eye - + - + - + PMID:21062451 - + PMID:21062451 @@ -33626,7 +33503,7 @@ plexiform layer. - + @@ -33679,14 +33556,14 @@ plexiform layer. http://upload.wikimedia.org/wikipedia/commons/b/b2/TE-Nervous_system_diagram.svg http://upload.wikimedia.org/wikipedia/commons/b/ba/Nervous_system_diagram.png - + - + Bgee:AN @@ -33774,7 +33651,7 @@ plexiform layer. - + The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the neural tube derivatives: the brain and spinal cord. In invertebrates it includes central ganglia plus nerve cord. Part of the nervous system which includes the brain and spinal cord.[AAO] @@ -33821,7 +33698,7 @@ plexiform layer. central nervous system - + @@ -33835,7 +33712,7 @@ plexiform layer. - + Bgee:AN @@ -34582,7 +34459,7 @@ plexiform layer. - + Simple squamous epithelium of mesodermal origin which lines serous membranes. Examples: mesothelium of pleura, mesothelium of peritoneum[FMA]. Wikipedia: The mesothelium is a membrane that forms the lining of several body cavities: the pleura (thoracal cavity), peritoneum (abdominal cavity including the mesentery) and pericardium (heart sac). Mesothelial tissue also surrounds the male internal reproductive organs (the tunica vaginalis testis) and covers the internal reproductive organs of women (the tunica serosa uteri). AEO:0000111 BTO:0002422 @@ -34607,14 +34484,14 @@ plexiform layer. mesothelium http://upload.wikimedia.org/wikipedia/commons/2/25/Mesothelium_peritoneal_wash_high_mag.jpg - + - + FMA @@ -34987,7 +34864,7 @@ plexiform layer. - + A tube extending from the mouth to the anus. @@ -35027,14 +34904,14 @@ plexiform layer. digestive tract - + - + NCBIBook:NBK10107 @@ -35114,7 +34991,7 @@ plexiform layer. - + The ciliary muscle is a ring of smooth muscle in the middle layer of the eye that controls the eye's accommodation for viewing objects at varying distances and regulates the flow of aqueous humour through Schlemm's canal. [WP,unvetted]. BTO:0000654 @@ -35137,7 +35014,7 @@ plexiform layer. ciliary muscle http://upload.wikimedia.org/wikipedia/commons/2/28/Gray872.png - + @@ -35156,7 +35033,7 @@ plexiform layer. - + FMA @@ -35297,7 +35174,7 @@ plexiform layer. - + @@ -35349,14 +35226,14 @@ plexiform layer. eyelid https://upload.wikimedia.org/wikipedia/commons/8/84/Eye_makeup.jpg - + - + multiple @@ -35651,7 +35528,7 @@ plexiform layer. - + @@ -35694,14 +35571,14 @@ plexiform layer. iris - + - + XAO @@ -35773,7 +35650,7 @@ plexiform layer. - + @@ -35825,14 +35702,14 @@ plexiform layer. corneal epithelium http://upload.wikimedia.org/wikipedia/commons/6/66/Gray871.png - + - + ISBN:0781772214 @@ -35928,16 +35805,16 @@ plexiform layer. - - + + - - + + @@ -35979,44 +35856,44 @@ plexiform layer. sclera http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg - + - + - + - + - + FMA - + ZFA - + ISBN:0781772214 - + cjm ISBN:0781772214 Wikipedia @@ -36076,7 +35953,7 @@ plexiform layer. - + @@ -36115,14 +35992,14 @@ plexiform layer. ciliary body http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg - + - + ISBN:0781772214 @@ -36170,14 +36047,14 @@ plexiform layer. - + - + @@ -36240,24 +36117,24 @@ plexiform layer. optic choroid http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg - + - + - + MA - + Wikipedia @@ -36357,7 +36234,7 @@ plexiform layer. - + @@ -36406,14 +36283,14 @@ plexiform layer. substantia propria of cornea http://upload.wikimedia.org/wikipedia/commons/6/66/Gray871.png - + - + cjm ISBN:0781772214 Wikipedia @@ -36490,9 +36367,9 @@ plexiform layer. - - - + + + A double layer covering the ciliary body that produces aqueous humor. BTO:0001770 @@ -36512,15 +36389,15 @@ plexiform layer. ciliary epithelium - + - + - + @@ -36533,19 +36410,19 @@ plexiform layer. - + MA - + MP - + Wikipedia @@ -36668,7 +36545,7 @@ plexiform layer. - + @@ -36729,14 +36606,14 @@ plexiform layer. pigmented layer of retina http://upload.wikimedia.org/wikipedia/commons/5/55/Gray881.png - + - + Wikipedia @@ -36840,7 +36717,7 @@ plexiform layer. - + @@ -36874,14 +36751,14 @@ plexiform layer. photoreceptor layer of retina http://upload.wikimedia.org/wikipedia/commons/5/55/Gray881.png - + - + ZFA @@ -37054,7 +36931,7 @@ plexiform layer. - + @@ -37101,14 +36978,14 @@ plexiform layer. outer nuclear layer of retina - + - + soma ZFA @@ -37446,7 +37323,7 @@ plexiform layer. - + @@ -37505,7 +37382,7 @@ plexiform layer. ganglionic layer of retina http://upload.wikimedia.org/wikipedia/commons/5/55/Gray881.png - + @@ -37518,7 +37395,7 @@ plexiform layer. - + FMA @@ -37594,7 +37471,7 @@ plexiform layer. - + @@ -37650,14 +37527,14 @@ plexiform layer. nerve fiber layer of retina - + - + FMA @@ -38035,7 +37912,7 @@ plexiform layer. - + @@ -38071,14 +37948,14 @@ plexiform layer. aqueous humor of eyeball http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg - + - + FMA def states A and P located_in in EHDAA2 VHOG @@ -38260,7 +38137,7 @@ plexiform layer. - + @@ -38284,7 +38161,7 @@ plexiform layer. vitreous body http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg - + @@ -38297,7 +38174,7 @@ plexiform layer. - + neural ectoderm of optic cup ISBN:0781772214 @@ -38432,8 +38309,8 @@ plexiform layer. - - + + @@ -38466,24 +38343,24 @@ plexiform layer. anterior segment of eyeball http://upload.wikimedia.org/wikipedia/commons/b/ba/Cataract_in_human_eye.png - + - + - + FMA - + cjm @@ -38534,8 +38411,8 @@ plexiform layer. - - + + @@ -38565,24 +38442,24 @@ plexiform layer. posterior segment of eyeball http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg - + - + - + FMA - + cjm @@ -38618,9 +38495,9 @@ plexiform layer. - - - + + + @@ -38670,15 +38547,15 @@ plexiform layer. conjunctiva http://upload.wikimedia.org/wikipedia/commons/5/55/Gray883.png - + - + - + @@ -38691,19 +38568,19 @@ plexiform layer. - + cjm - + MA - + ISBN:0781772214 @@ -38767,7 +38644,7 @@ plexiform layer. - + The most anterior region of the brain including both the telencephalon and diencephalon. @@ -38814,14 +38691,14 @@ plexiform layer. forebrain http://upload.wikimedia.org/wikipedia/commons/5/54/EmbryonicBrain.svg - + - + definitional @@ -38897,14 +38774,14 @@ plexiform layer. - + - + The midbrain is the middle division of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes a ventral part containing the cerebral peduncles and a dorsal tectum containing the corpora quadrigemina and that surrounds the aqueduct of Sylvius connecting the third and fourth ventricles)[GO]. developmental relationships need revised @@ -38957,24 +38834,24 @@ plexiform layer. midbrain http://upload.wikimedia.org/wikipedia/commons/f/f9/Human_brain_inferior_view_description.JPG - + - + - + definitional - + Bgee:AN @@ -39077,14 +38954,14 @@ plexiform layer. - + - + The division of the forebrain that develops from the foremost primary cerebral vesicle. @@ -39147,24 +39024,24 @@ plexiform layer. diencephalon http://upload.wikimedia.org/wikipedia/commons/5/54/EmbryonicBrain.svg - + - + - + definitional - + definitional @@ -39600,7 +39477,7 @@ plexiform layer. - + Ventral part of the midbrain, separated from the hindbrain by the isthmus[ISBN:0471888893]. Subdivision of the midbrain lying anterior to the tectum and posterior to the substantia nigra and cerebral peduncle[FMA] The part of the midbrain extending from the substantia nigra to the cerebral aqueduct in a horizontal section of the midbrain. It forms the floor of the midbrain that surrounds the cerebral aqueduct[WP]. Together, our results reveal a shared basic organization in the tegmental domains of the diencephalon and midbrain of developing lamprey, indicating early appearance of the domain in vertebrate phylogeny.[well established][VHOG] @@ -39640,14 +39517,14 @@ plexiform layer. midbrain tegmentum http://upload.wikimedia.org/wikipedia/commons/b/b6/Gray712.png - + - + ZFA @@ -39826,8 +39703,8 @@ plexiform layer. - - + + @@ -39840,7 +39717,7 @@ plexiform layer. - + @@ -39899,34 +39776,34 @@ plexiform layer. blood vessel http://upload.wikimedia.org/wikipedia/commons/2/29/Circulatory_System_en.svg - + - + - + - + AEO - + EHDAA2 - + GO:0072360 @@ -40285,7 +40162,7 @@ plexiform layer. - + @@ -40298,7 +40175,7 @@ plexiform layer. - + The most posterior of the three principal regions of the brain. In mammals and birds the hindbrain is divided into a rostral metencephalon and a caudal myelencephalon. In zebrafish, with the exception of the cerebellum, the ventral remainder of the metencephalon can be separated only arbitrarily from the more caudal myelencephalic portion of the medulla oblongata (From: Neuroanatomy of the Zebrafish Brain)[ZFA]. Organ component of neuraxis that has as its parts the pons, cerebellum and medulla oblongata[FMA]. @@ -40349,25 +40226,25 @@ plexiform layer. hindbrain http://upload.wikimedia.org/wikipedia/commons/5/54/EmbryonicBrain.svg - + - + - + modified-source-relation ABA - + Bgee:AN @@ -41186,7 +41063,7 @@ plexiform layer. - + Vasculature that is part of the eye region. not part of the eye in ZFA. Note this changed to a blood vessel in ZFA @@ -41207,14 +41084,14 @@ plexiform layer. vasculature of eye - + - + ISBN:0781772214 @@ -41273,7 +41150,7 @@ plexiform layer. - + @@ -41307,14 +41184,14 @@ plexiform layer. musculoskeletal system - + - + check ctenophore @@ -41452,15 +41329,15 @@ plexiform layer. - + - - + + Part of the central nervous system located in the vertebral canal continuous with and caudal to the brain; demarcated from brain by plane of foramen magnum. It is composed of an inner core of gray matter in which nerve cells predominate, and an outer layer of white matter in which myelinated nerve fibers predominate, and surrounds the central canal. (CUMBO). TODO - add superclass to unify with VNC? @@ -41517,34 +41394,34 @@ plexiform layer. spinal cord http://upload.wikimedia.org/wikipedia/commons/5/58/Spinal_cord_direv.svg - + - + - + - + ZFA - + definitional - + definitional @@ -41986,7 +41863,7 @@ plexiform layer. - + @@ -42027,14 +41904,14 @@ plexiform layer. coelemic cavity lumen - + - + definitional @@ -42142,9 +42019,9 @@ plexiform layer. - - - + + + @@ -42199,15 +42076,15 @@ plexiform layer. notochord http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png - + - + - + @@ -42226,19 +42103,19 @@ plexiform layer. - + http://tolweb.org/Chordata/2499 - + ZFA - + EHDAA2 @@ -42323,8 +42200,8 @@ plexiform layer. - - + + Somites are spheres of epithelial cells that form sequentially along the anterior-posterior axis of the embryo through mesenchymal to epithelial transition of the presomitic mesoderm. currently classified as an epithelial vesicle, consistent with EHDAA2 and https://github.com/obophenotype/uberon/wiki/The-neural-crest. Consider making 'somitic mesoderm' a separate term and correlate with regionalization processes. Consider moving ZFA term to 'trunk somite' as it is part of the trunk @@ -42370,11 +42247,11 @@ plexiform layer. somite http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png - + - + @@ -42387,13 +42264,13 @@ plexiform layer. - + GOTAX:0000352 - + ZFA @@ -42506,12 +42383,12 @@ plexiform layer. + + + + - - - - A specialized region of ectoderm found between the neural ectoderm (neural plate) and non-neural ectoderm and composed of highly migratory pluripotent cells that delaminate in early embryonic development from the dorsal neural tube and give rise to an astounding variety of differentiated cell types[MP]. consider including subclasses for pre- and post- migratory (e.g. sheets/paths/streams). @@ -42551,66 +42428,66 @@ plexiform layer. http://upload.wikimedia.org/wikipedia/commons/5/5f/Gray644.png https://upload.wikimedia.org/wikipedia/commons/8/8f/Neural_Crest.png - + - + - + - + - + - + - + XAO https://github.com/obophenotype/uberon/wiki/The-neural-crest - + Hall and others restrict NC to vertebrates but we opt for a less restrictive constraint to avoid inconsistencies when areas such as P1 area of pallium in hagfishes inherit cell lineage from telecephalon-contributing NC cells ISBN:0073040584 - + BTO - + PMID:11523831 - + pre migratory https://github.com/obophenotype/uberon/wiki/The-neural-crest - + PMID:11523831 @@ -42993,14 +42870,14 @@ plexiform layer. - + - + Anatomical system that is involved in the production of hematopoietic cells. Anatomical system that consists of the blood and blood forming tissues.[AAO] @@ -43043,24 +42920,24 @@ plexiform layer. hematopoietic system - + - + - + FMA - + definitional @@ -43125,8 +43002,8 @@ plexiform layer. - - + + @@ -43152,11 +43029,11 @@ plexiform layer. iris epithelium - + - + @@ -43169,13 +43046,13 @@ plexiform layer. - + MA - + MP @@ -43325,7 +43202,7 @@ plexiform layer. - + Ectodermal placode that develops in the head into a part of the sensory nervous system. With a few exceptions (lens, adenohypophyseal), cranial placodes are neurogenic. Do not merge with neurogenic placode Comparisons of developmental gene expression suggest that the anterior ectoderm in amphioxus may be homologous to the vertebrate olfactory placode, the only vertebrate placode with primary, not secondary, neurons @@ -43345,7 +43222,7 @@ plexiform layer. cranial placode - + @@ -43358,7 +43235,7 @@ plexiform layer. - + PMID:11523831 PMID:22512454 @@ -43563,7 +43440,7 @@ plexiform layer. - + @@ -43576,7 +43453,7 @@ plexiform layer. - + The part of the brain that is the morphological boundary between the midbrain and hindbrain and that is the location of an organizing center which patterns the midbrain and hindbrain primordia of the neural plate. consider adding class for organizer. Consider adding separate class for isthmus as a structure Lampreys also have an MHB [midbrain hindbrain boundary], expressing a similar repertoire of regulatory gene cognates as in gnathostomes.[well established][VHOG] @@ -43606,11 +43483,11 @@ plexiform layer. midbrain-hindbrain boundary - + - + @@ -43624,13 +43501,13 @@ plexiform layer. - + ZFA - + ZFA @@ -43795,7 +43672,7 @@ plexiform layer. - + Unsegmented field of paraxial mesoderm present posterior to the most recently formed somite pair, from which somites will form. Unsegmented field of paraxial mesoderm present posterior to the most recently formed somite pair, from which somites will form. Kimmel et al, 1995.[TAO] It is reasonable to assume that the proximate invertebrate ancestor of the vertebrates had an amphioxus-like tail bud in its larval stage. This archetypal tail bud would have (...) (3) lacked any component of mesenchyme cells, (4) budded off new mesodermal segments directly, without any intervening zone of presomitic mesoderm (...). Then, early in vertebrate evolution, epithelium-to-mesenchyme interconversions (and the gene networks for effecting them) became prominent features of development. (...) In any case, conspicuous mesenchymal components tended to be added to the vertebrate tail bud itself. In addition, a mesenchymatous presomitic mesoderm (not a part of the tail bud proper) came to intervene between the tail bud and the forming somites.[well established][VHOG] @@ -43820,14 +43697,14 @@ plexiform layer. presomitic mesoderm - + - + Bgee:AN @@ -44069,7 +43946,7 @@ plexiform layer. - + @@ -44107,7 +43984,7 @@ plexiform layer. eye primordium - + @@ -44120,7 +43997,7 @@ plexiform layer. - + PMID:16496288 XAO @@ -44176,8 +44053,8 @@ plexiform layer. - - + + @@ -44206,24 +44083,24 @@ plexiform layer. optic cup - + - + - + ZFA - + ZFA @@ -44288,7 +44165,7 @@ plexiform layer. - + @@ -44329,7 +44206,7 @@ plexiform layer. lens placode http://upload.wikimedia.org/wikipedia/commons/2/2f/Gray864.png - + @@ -44342,7 +44219,7 @@ plexiform layer. - + ZFA @@ -44406,9 +44283,9 @@ plexiform layer. - - - + + + A region of embryonic ectodermal cells that lie directly above the notochord. During neurulation, they change shape and produce an infolding of the neural plate (the neural fold) that then seals to form the neural tube[XAO]. The earliest recognizable dorsal ectodermal primordium of the central nervous system present near the end of gastrulation before infolding to form the neural keel; consists of a thickened pseudostratified epithelium[ZFA]. The earliest recognizable dorsal ectodermal primordium of the central nervous system present near the end of gastrulation before infolding to form the neural keel; consists of a thickened pseudostratified epithelium. Kimmel et al, 1995.[TAO] (...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...).[well established][VHOG] @@ -44440,34 +44317,34 @@ plexiform layer. neural plate https://upload.wikimedia.org/wikipedia/commons/8/8f/Neural_Crest.png - + - + - + - + GOTAX:0000352 - + Wikipedia - + Bgee:AN @@ -44578,7 +44455,7 @@ plexiform layer. - + The paraxial mesoderm is the mesoderm located bilaterally adjacent to the notochord and neural tube[GO]. Mesoderm lateral to the neural tube and notochord that is divided into cranial and post-cranial portions. The trunk portions further segment into somites.[AAO] Presently, Cephalochordata, Urochordata, and Vertebrata are placed as subphyla of the phylum Chordata, in which the overall organization of embryonic tissues (dorsal hollow nerve cord, ventral digestive tract, axial notochord, and bilateral paraxial mesoderm) is largely conserved. In contrast, the echinoderms and hemichordates are sister groups of the chordates and they lack the notochord and paraxial mesoderm. Thus, the basic mesodermal organization of vertebrates must have appeared first in the common ancestor of the chordates.[well established][VHOG] @@ -44607,7 +44484,7 @@ plexiform layer. paraxial mesoderm http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png - + @@ -44620,7 +44497,7 @@ plexiform layer. - + Bgee:AN @@ -44732,7 +44609,7 @@ plexiform layer. - + @@ -44776,7 +44653,7 @@ plexiform layer. lateral plate mesoderm http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png - + @@ -44789,7 +44666,7 @@ plexiform layer. - + EHDAA2 VHOG @@ -44873,15 +44750,15 @@ plexiform layer. - - + + - + Bilateral groups of cells consisting of three rows: one row of endocardial precursors medially and two rows of myocardical precursors laterally. The two populations fuse at the midline to form the heart rudiment or cone. should probably be merged with heart rudiment. Bilateral groups of cells consisting of three rows: one row of endocardial precursors medially and two rows of myocardical precursors laterally. The two populations fuse at the midline between 21 and 26 somites to form the heart rudiment or cone. Stainier 2001.[TAO] @@ -44901,15 +44778,15 @@ plexiform layer. heart primordium - + - + - + @@ -44922,19 +44799,19 @@ plexiform layer. - + ZFA - + ZFA - + XAO @@ -44989,8 +44866,8 @@ plexiform layer. - - + + Ventral somitic compartment that is a precursor of the axial skeleton[XAO]. Sclerotomes eventually differentiate into the vertebrae and most of the skull. The caudal (posterior) half of one sclerotome fuses with the rostral (anterior) half of the adjacent one to form each vertebra. From their initial location within the somite, the sclerotome cells migrate medially towards the notochord. These cells meet the sclerotome cells from the other side to form the vertebral body. From this vertebral body, sclerotome cells move dorsally and surround the developing spinal cord, forming the vertebral arch[WP]. Skeletogenic portion of somites.[AAO] The vertebrate sclerotome has no equivalent in amphioxus and is a novelty linked with the evolution of the axial skeleton.[well established][VHOG] @@ -45017,11 +44894,11 @@ plexiform layer. sclerotome http://upload.wikimedia.org/wikipedia/commons/9/96/Gray65.png - + - + @@ -45040,13 +44917,13 @@ plexiform layer. - + VHOG:0000680 - + ZFA @@ -45464,7 +45341,7 @@ plexiform layer. - + Mesenchyme that is part of a developing camera-type eye. TODO - change mesenchyme relationships to precursor_of EHDAA2:0000485 @@ -45476,14 +45353,14 @@ plexiform layer. UBERON:0003314 eye mesenchyme - + - + EHDAA2 @@ -46341,7 +46218,7 @@ plexiform layer. - + The part of the coelom in the embryo between the somatopleuric and splanchnopleuric mesoderm; the principal body cavities of the trunk (thoracic, abdominal, and pelvic) arise from this embryonic part of the coelom. consider merging with coelom. TODO - add spatial relationships to halves of LPM. Note the OG places XAO and ZFA coelem terms here. editor note: TODO check ZFA, which appears to be a structure present in adults (...) I regard it unlikely that coeloms of all bilaterian animals are comparable and evolved very early. Considering all these questions, few convincing characters concerning the evolution of body cavities remain to be named. (...) A segmental coelom appears to have evolved at least two times, in Annelida and in Myomerata (Acrania and Craniota).[well established][VHOG] @@ -46357,14 +46234,14 @@ plexiform layer. intraembryonic coelom - + - + Wikipedia @@ -46469,7 +46346,7 @@ plexiform layer. - + The part of the retina that contains neurons and photoreceptor cells[GO]. (...) an essentially similar sequence of events occurs during the embryonic development of the vertebrate eye. The eye initially develops as a single median evagination of the diencephalon that soon bifurcates to form the paired optic vesicles. As each optic vesicle grows towards the body surface, its proximal part narrows as the optic stalk, and its distal part invaginates to form a two-layered optic cup. (...) The outer layer of the optic cup becomes the pigment layer of the retina, whereas the inner layer differentiates into the photoreceptive cells and neuronal layers of the retina.[well established][VHOG] @@ -46501,14 +46378,14 @@ plexiform layer. retinal neural layer - + - + Bgee:AN @@ -46766,7 +46643,7 @@ plexiform layer. - + The layer of undifferentiated, proliferating cells that line the neural tube lumen that is the immediate transformation of the germinal neuroepithelium. consider merging with 'ventricular zone'; note that the MA class probably does not belong here, as this is an embryonic structure The layer of undifferentiated, proliferating cells that line the neural tube lumen @@ -46784,7 +46661,7 @@ plexiform layer. neural tube ventricular layer - + @@ -46797,7 +46674,7 @@ plexiform layer. - + NCBIBook:NBK10047 @@ -46857,7 +46734,7 @@ plexiform layer. - + @@ -46881,7 +46758,7 @@ plexiform layer. neural tube mantle layer - + @@ -46894,7 +46771,7 @@ plexiform layer. - + by division NCBIBook:NBK10047 @@ -46931,7 +46808,7 @@ plexiform layer. - + @@ -46948,14 +46825,14 @@ plexiform layer. neural tube marginal layer - + - + forms from axons @@ -47230,9 +47107,9 @@ plexiform layer. - - - + + + @@ -47265,34 +47142,34 @@ plexiform layer. optic vesicle http://upload.wikimedia.org/wikipedia/commons/e/e0/Gray863.png - + - + - + - + ZFA - + GO-def - + ZFA @@ -47408,8 +47285,8 @@ plexiform layer. - - + + A specific region of the lateral mesoderm that will form the primary beating heart tube. In mammals the primary heart field gives rise to the left ventricle. this term denotes the primary heart field; GO:0003128 denotes the superclass of primary and secondary: specific region of the lateral mesoderm into the area which will form the primary beating heart tube[GO:0003138] XAO:0004185 @@ -47422,24 +47299,24 @@ plexiform layer. UBERON:0004140 primary heart field - + - + - + GO:0003128 - + https://orcid.org/0000-0003-3308-6245 @@ -47498,7 +47375,7 @@ plexiform layer. - + An epithelial tube that will give rise to the mature heart. the paired, longitudinal, endothelial-lined channels formed from the cardiogenic mesoderm in embryonic development; angiogenic cell clusters (aka angioblastic cords) located in a horse-shoe shape configuration in the cardiogenic plate coalesce to form the right and left endocardial heart tubes which then fuse in cephalo-caudal direction to form a single primitive heart tube. AAO:0010411 @@ -47518,14 +47395,14 @@ plexiform layer. heart tube - + - + ZFA-modified @@ -47606,7 +47483,7 @@ plexiform layer. - + @@ -47622,14 +47499,14 @@ plexiform layer. eye muscle - + - + MA @@ -47833,7 +47710,7 @@ plexiform layer. - + A transparent homogeneous acellular layer found between the substantia propria and the endothelial layer of the cornea[MP]. Acellular anatomical structure composed of collagen, Descemet's membrane is secreted as a basement membrane of the corneal endothelium. Located between the stroma and the corneal endothelium, it is approximately 0.15 micrometer thick at 6 months post-fertilization.[ZFIN] @@ -47863,14 +47740,14 @@ plexiform layer. Descemet's membrane https://github.com/obophenotype/uberon/issues/15 - + - + Cline et al @@ -48651,7 +48528,7 @@ plexiform layer. - + Organ consisting of skeletal tissue. Encompasses whole bones, fused bones, cartilaginious elements, teeth, dermal denticles. Organ entity that is typically involved in mechanical support and may have different skeletal tissue compositions at different stages.[VSAO] Organ entity that may have different tissue compositions at different stages and is typically involved in mechanical support.[TAO] @@ -48667,14 +48544,14 @@ plexiform layer. skeletal element - + - + VSAO @@ -48719,7 +48596,7 @@ plexiform layer. - + @@ -48758,14 +48635,14 @@ plexiform layer. UBERON:0004770 articular system - + - + FMA @@ -49672,7 +49549,7 @@ plexiform layer. - + Portion of primordial embryonic connective tissue of the developing head, consisting of mesenchymal cells supported in interlaminar jelly, that derive mostly from the mesoderm and contribute to head connective tissue, bone and musculature in conjunction with cranial neural crest cells. Mesoderm that will give rise, along with cranial neural crest cells, to connective tissue, bone and musculature in the head. (Source: BioGlossary, www.Biology-Text.com)[TAO] EFO:0003492 @@ -49694,14 +49571,14 @@ plexiform layer. head mesenchyme - + - + EHDAA2 @@ -49768,7 +49645,7 @@ plexiform layer. - + Mesenchyme that is part of a developing trunk. EFO:0003485 EHDAA2:0002092 @@ -49784,14 +49661,14 @@ plexiform layer. trunk mesenchyme - + - + EHDAA2 @@ -49814,7 +49691,7 @@ plexiform layer. - + The posterior part of the developing vertebrate hindbrain or the corresponding part of the adult brain composed of the medulla oblongata and a portion of the fourth ventricle; as well as the glossopharyngeal nerve (CN IX), vagus nerve (CN X), accessory nerve (CN XI), hypoglossal nerve (CN XII), and a portion of the vestibulocochlear nerve (CN VIII).[BTO,WP]. The posterior of the two brain vesicles formed by specialization of the rhombencephalon in the developing embryo, it comprises the medulla oblongata. [TFD][VHOG] @@ -49839,14 +49716,14 @@ plexiform layer. myelencephalon http://upload.wikimedia.org/wikipedia/commons/5/54/EmbryonicBrain.svg - + - + definitional @@ -50373,7 +50250,7 @@ plexiform layer. - + Portion of tissue that is part of the eye and gives rise to the mature, fully layered cornea. TAO:0002188 ZFA:0001688 @@ -50381,7 +50258,7 @@ plexiform layer. UBERON:0005427 corneal primordium - + @@ -50400,7 +50277,7 @@ plexiform layer. - + ZFA @@ -50423,7 +50300,7 @@ plexiform layer. - + Multi-tissue structure that arises from the heart rudiment and will become the heart tube. EHDAA2:0001512 EHDAA:424 @@ -50441,14 +50318,14 @@ plexiform layer. primitive heart tube - + - + ZFA @@ -50651,7 +50528,7 @@ plexiform layer. - + A delimited region of dense mesenchyme within looser mesenchyme. AEO:0000148 EHDAA2_RETIRED:0003148 @@ -50661,7 +50538,7 @@ plexiform layer. UBERON:0005856 developing mesenchymal condensation - + @@ -50680,7 +50557,7 @@ plexiform layer. - + AEO-modified-relation @@ -50739,9 +50616,9 @@ plexiform layer. - - - + + + A serous sac which is the aggregate of the conjunctiva plus the conjunctival space. EMAPA:18233 FMA:20291 @@ -50752,15 +50629,15 @@ plexiform layer. UBERON:0005908 conjunctival sac - + - + - + @@ -50773,19 +50650,19 @@ plexiform layer. - + FMA - + HPO:pr - + MA @@ -51040,7 +50917,7 @@ plexiform layer. - + @@ -51063,14 +50940,14 @@ plexiform layer. future diencephalon - + - + EHDAA2 @@ -51253,7 +51130,7 @@ plexiform layer. - + @@ -51277,14 +51154,14 @@ plexiform layer. future spinal cord - + - + EHDAA2 @@ -51321,7 +51198,7 @@ plexiform layer. - + The notochordal plate is the dorsal part of the notochordal process when the ventral portion breaks down. It is continuous laterally with the endoderm that composes the roof of the primitive foregut and is in contact dorsally with the neural tube. The folding off of the notochordal plate gives rise to the notochord. TODO - check ordering; awaiting confirmation from JB The notochordal plate is the dorsal part of the notochordal process when the ventral portion breaks down. It is continuous laterally with the endoderm that composes the roof of the primitive foregut and is in contact dorsally with the neural tube. The folding off of the notochordal plate gives rise to the notochord. [Carson_JL, Dehart_DB, Developmental_Dynamics_(1994)_201:_260-278, Gesteland_K_and_Schoenwolf_GC, Inagaki_T, Morphogenesis_of_the_murine_node_and_notochordal_plate, The_prechordal_plate, Vrablic_T, see_Mueller_F_and_O'Rahilly_R, the_rostral_end_of_the_notochord_and_nearby_median_features_in_staged_human_embryos._Cells_Tissues_Organs_(2003)_173:_1-20_and_Sulik_K][VHOG] @@ -51336,7 +51213,7 @@ plexiform layer. notochordal plate - + @@ -51349,7 +51226,7 @@ plexiform layer. - + EHDAA2 @@ -51386,7 +51263,7 @@ plexiform layer. - + A midline cellular cord formed from the migration of mesenchymal cells from the primitive knot. EHDAA2:0001279 EHDAA:224 @@ -51403,14 +51280,14 @@ plexiform layer. The notochordal process grows cranially until it reaches the prechordal plate, the future site of the mouth. In this area the ectoderm is attached directly to the endoderm without intervening mesoderm. This area is known as the oropharyngeal membrane, and it will break down to become the mouth. At the other end of the primitive streak the ectoderm is also fused directly to the endoderm; this is known as the cloacal membrane (proctodeum), or primordial anus. notochordal process - + - + EHDAA2 @@ -52315,7 +52192,7 @@ plexiform layer. - + A hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood or analogs[GO,modified]. note we reserve the subclass 'heart' from the vertebrate multi-chambered heart. 'The first heart-like organ is believed to have appeared 500my ago in an ancestral bilaterian'. Amniotes: four-chambered heart. Amphibians: two atria, one ventricle, pulmonary; fish: single atrium and ventricle; amphioxus: tubular, non-striated, closed, unidirectional; ascidians: tubular, striated, open, bidirectional; arthropods: tubular, open; C elegans: contractile pharynx; Cnideria: striated muscle cells associated with gastrodermis SPD:0000130 @@ -52330,14 +52207,14 @@ plexiform layer. Gene notes: Bmp, Nkx, Gata primary circulatory organ - + - + GO uses blood circulation generically to include the haemolymphatic fluid of arthropods @@ -52492,8 +52369,8 @@ plexiform layer. - - + + @@ -52520,24 +52397,24 @@ plexiform layer. presumptive hindbrain - + - + - + XAO-abduced - + cjm @@ -52594,7 +52471,7 @@ plexiform layer. - + @@ -52613,14 +52490,14 @@ plexiform layer. presumptive midbrain hindbrain boundary - + - + ZFA @@ -52659,7 +52536,7 @@ plexiform layer. - + @@ -52676,14 +52553,14 @@ plexiform layer. presumptive segmental plate - + - + https://github.com/obophenotype/uberon/wiki/The-neural-crest EDHAA2 @@ -52782,7 +52659,7 @@ plexiform layer. - + @@ -52808,7 +52685,7 @@ plexiform layer. presumptive paraxial mesoderm - + @@ -52824,7 +52701,7 @@ plexiform layer. - + https://github.com/obophenotype/uberon/issues/1277 @@ -52906,7 +52783,7 @@ plexiform layer. - + A neural decussation that is part of a diencephalon. FMA:62446 diencephalon decussation @@ -52914,7 +52791,7 @@ plexiform layer. UBERON:0007425 decussation of diencephalon - + @@ -52927,7 +52804,7 @@ plexiform layer. - + Obol @@ -53002,7 +52879,7 @@ plexiform layer. - + Mesenchyme with little extracellular matrix. AEO:0000146 EHDAA2:0003146 @@ -53010,7 +52887,7 @@ plexiform layer. UBERON:0007524 dense mesenchyme tissue - + @@ -53023,7 +52900,7 @@ plexiform layer. - + AEO @@ -53263,7 +53140,7 @@ plexiform layer. - + An axon tract that is part of a brain. the NIFSTD class 'nerve tract' is classified under 'regional part of brain', so it may seem like it belongs here, but actually includes spinal cord tracts FMA:83848 @@ -53273,14 +53150,14 @@ plexiform layer. UBERON:0007702 tract of brain - + - + cjm @@ -53308,7 +53185,7 @@ plexiform layer. - + Anatomical system that consists of all blood and lymph vessels. consider merging with vasculature The cardiovascular and lymphatic systems, collectively[ncithesaurus:Vascular_System]. @@ -53325,14 +53202,14 @@ plexiform layer. vascular system - + - + MA @@ -53465,7 +53342,7 @@ plexiform layer. - + @@ -53482,14 +53359,14 @@ plexiform layer. UBERON:0009142 entire embryonic mesenchyme - + - + EHDAA2 @@ -53585,8 +53462,8 @@ plexiform layer. - - + + TODO - developmental relationships for lines TAO:0007044 ZFA:0007044 @@ -53596,24 +53473,24 @@ plexiform layer. UBERON:0009615 midbrain hindbrain boundary neural plate - + - + - + ZFA - + https://github.com/obophenotype/uberon/issues/438 Bgee:AN @@ -53647,14 +53524,14 @@ plexiform layer. - + - + @@ -53679,24 +53556,24 @@ plexiform layer. presumptive midbrain - + - + - + ZFA - + ZFA @@ -53742,7 +53619,7 @@ plexiform layer. - + EHDAA2:0002094 trunk and cervical paraxial mesenchyme uberon @@ -53750,14 +53627,14 @@ plexiform layer. UBERON:0009618 trunk paraxial mesoderm - + - + EHDAA2 @@ -53779,7 +53656,7 @@ plexiform layer. - + EFO:0003704 TAO:0005041 ZFA:0005041 @@ -53789,14 +53666,14 @@ plexiform layer. anterior lateral plate mesoderm - + - + ZFA @@ -53852,14 +53729,14 @@ plexiform layer. - + EHDAA2:0001315 EHDAA:1122 uberon UBERON:0009920 optic neural crest - + @@ -53872,7 +53749,7 @@ plexiform layer. - + EHDAA2 @@ -54006,7 +53883,7 @@ plexiform layer. - + @@ -54031,14 +53908,14 @@ plexiform layer. eyeball of camera-type eye - + - + FMA @@ -54079,8 +53956,8 @@ plexiform layer. - - + + Portion of tissue that is dorsolateral to the floor plate and part of the midbrain. DHBA:12322 EFO:0003567 @@ -54094,11 +53971,11 @@ plexiform layer. midbrain basal plate - + - + @@ -54111,13 +53988,13 @@ plexiform layer. - + EHDAA2 - + ZFA @@ -54145,7 +54022,7 @@ plexiform layer. - + Portion of neural tube that gives rise to the midbrain. we follow ZFA in temporally dividing midbrain NT from presumptive midbrain, but in future this may be collapsed TAO:0007039 @@ -54154,14 +54031,14 @@ plexiform layer. UBERON:0010286 midbrain neural tube - + - + ZFA @@ -54188,7 +54065,7 @@ plexiform layer. - + @@ -54204,14 +54081,14 @@ plexiform layer. UBERON:0010312 immature eye - + - + definitional @@ -54481,8 +54358,8 @@ plexiform layer. - - + + Anatomical cluster consisting of the skeletal elements (i.e. bone elements, cartilage elements, cartilage condensations) that are part of an individual subdivision of the organism. Excludes joints. Anatomical cluster consisting of the skeletal elements that are part of the skeleton.[VSAO] FMA:23879 @@ -54495,11 +54372,11 @@ plexiform layer. subdivision of skeleton - + - + @@ -54512,13 +54389,13 @@ plexiform layer. - + UBERONREF:0000003 - + VSAO @@ -54595,7 +54472,7 @@ plexiform layer. - + Subdivision of the skeletal system which consists of the postcranial axial skeleton plus associated joints. axial skeletal system FMA:302077 @@ -54605,7 +54482,7 @@ plexiform layer. postcranial axial skeletal system http://purl.obolibrary.org/obo/uberon/docs/The-axial-skeleton - + @@ -54618,7 +54495,7 @@ plexiform layer. - + cjm @@ -54730,7 +54607,7 @@ plexiform layer. - + Muscles within the eye (bulbus oculi).[AAO] AAO:0010038 EMAPA:18808 @@ -54741,14 +54618,14 @@ plexiform layer. UBERON:0011222 intra-ocular muscle - + - + EMAPA @@ -55018,7 +54895,7 @@ plexiform layer. - + @@ -55060,7 +54937,7 @@ plexiform layer. anterior uvea - + @@ -55073,7 +54950,7 @@ plexiform layer. - + MP @@ -55849,7 +55726,7 @@ plexiform layer. - + @@ -55872,7 +55749,7 @@ plexiform layer. UBERON:0016887 entire extraembryonic component - + @@ -55885,7 +55762,7 @@ plexiform layer. - + AEO @@ -56637,196 +56514,6 @@ plexiform layer. - - - - - - - - - example to be eventually removed - example to be eventually removed - - - - - - - - failed exploratory term - The term was used in an attempt to structure part of the ontology but in retrospect failed to do a good job - Person:Alan Ruttenberg - failed exploratory term - - - - - - - - metadata complete - Class has all its metadata, but is either not guaranteed to be in its final location in the asserted IS_A hierarchy or refers to another class that is not complete. - metadata complete - - - - - - - - organizational term - Term created to ease viewing/sort terms for development purpose, and will not be included in a release - organizational term - - - - - - - - ready for release - Class has undergone final review, is ready for use, and will be included in the next release. Any class lacking "ready_for_release" should be considered likely to change place in hierarchy, have its definition refined, or be obsoleted in the next release. Those classes deemed "ready_for_release" will also derived from a chain of ancestor classes that are also "ready_for_release." - ready for release - - - - - - - - metadata incomplete - Class is being worked on; however, the metadata (including definition) are not complete or sufficiently clear to the branch editors. - metadata incomplete - - - - - - - - uncurated - Nothing done yet beyond assigning a unique class ID and proposing a preferred term. - uncurated - - - - - - - - pending final vetting - All definitions, placement in the asserted IS_A hierarchy and required minimal metadata are complete. The class is awaiting a final review by someone other than the term editor. - pending final vetting - - - - - - - - placeholder removed - placeholder removed - - - - - - - - terms merged - An editor note should explain what were the merged terms and the reason for the merge. - terms merged - - - - - - - - term imported - This is to be used when the original term has been replaced by a term imported from an other ontology. An editor note should indicate what is the URI of the new term to use. - term imported - - - - - - - - term split - This is to be used when a term has been split in two or more new terms. An editor note should indicate the reason for the split and indicate the URIs of the new terms created. - term split - - - - - - - - universal - Hard to give a definition for. Intuitively a "natural kind" rather than a collection of any old things, which a class is able to be, formally. At the meta level, universals are defined as positives, are disjoint with their siblings, have single asserted parents. - Alan Ruttenberg - A Formal Theory of Substances, Qualities, and Universals, http://ontology.buffalo.edu/bfo/SQU.pdf - universal - - - - - - - - defined class - A defined class is a class that is defined by a set of logically necessary and sufficient conditions but is not a universal - "definitions", in some readings, always are given by necessary and sufficient conditions. So one must be careful (and this is difficult sometimes) to distinguish between defined classes and universal. - Alan Ruttenberg - defined class - - - - - - - - named class expression - A named class expression is a logical expression that is given a name. The name can be used in place of the expression. - named class expressions are used in order to have more concise logical definition but their extensions may not be interesting classes on their own. In languages such as OWL, with no provisions for macros, these show up as actuall classes. Tools may with to not show them as such, and to replace uses of the macros with their expansions - Alan Ruttenberg - named class expression - - - - - - - - to be replaced with external ontology term - Terms with this status should eventually replaced with a term from another ontology. - Alan Ruttenberg - group:OBI - to be replaced with external ontology term - - - - - - - - requires discussion - A term that is metadata complete, has been reviewed, and problems have been identified that require discussion before release. Such a term requires editor note(s) to identify the outstanding issues. - Alan Ruttenberg - group:OBI - requires discussion - - - - - + + symbol + @@ -75,34 +77,7 @@ - definition - - The official definition, explaining the meaning of a class or property. Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions. - 2012-04-05: -Barry Smith - -The official OBI definition, explaining the meaning of a class or property: 'Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions' is terrible. - -Can you fix to something like: - -A statement of necessary and sufficient conditions explaining the meaning of an expression referring to a class or property. - -Alan Ruttenberg - -Your proposed definition is a reasonable candidate, except that it is very common that necessary and sufficient conditions are not given. Mostly they are necessary, occasionally they are necessary and sufficient or just sufficient. Often they use terms that are not themselves defined and so they effectively can't be evaluated by those criteria. - -On the specifics of the proposed definition: - -We don't have definitions of 'meaning' or 'expression' or 'property'. For 'reference' in the intended sense I think we use the term 'denotation'. For 'expression', I think we you mean symbol, or identifier. For 'meaning' it differs for class and property. For class we want documentation that let's the intended reader determine whether an entity is instance of the class, or not. For property we want documentation that let's the intended reader determine, given a pair of potential relata, whether the assertion that the relation holds is true. The 'intended reader' part suggests that we also specify who, we expect, would be able to understand the definition, and also generalizes over human and computer reader to include textual and logical definition. - -Personally, I am more comfortable weakening definition to documentation, with instructions as to what is desirable. - -We also have the outstanding issue of how to aim different definitions to different audiences. A clinical audience reading chebi wants a different sort of definition documentation/definition from a chemistry trained audience, and similarly there is a need for a definition that is adequate for an ontologist to work with. - PERSON:Daniel Schober - GROUP:OBI:<http://purl.obolibrary.org/obo/obi> - definition - definition @@ -110,19 +85,12 @@ We also have the outstanding issue of how to aim different definitions to differ - editor note - - An administrative note intended for its editor. It may not be included in the publication version of the ontology, so it should contain nothing necessary for end users to understand the ontology. - PERSON:Daniel Schober - GROUP:OBI:<http://purl.obofoundry.org/obo/obi> IAO:0000116 uberon editor_note true editor_note - editor note - editor note @@ -147,13 +115,7 @@ We also have the outstanding issue of how to aim different definitions to differ - - has obsolescence reason - Relates an annotation property to an obsolescence reason. The values of obsolescence reasons come from a list of predefined terms, instances of the class obsolescence reason specification. - PERSON:Alan Ruttenberg - PERSON:Melanie Courtot - has obsolescence reason - + @@ -166,12 +128,6 @@ We also have the outstanding issue of how to aim different definitions to differ - term tracker item - the URI for an OBI Terms ticket at sourceforge, such as https://sourceforge.net/p/obi/obi-terms/772/ - - An IRI or similar locator for a request or discussion of an ontology term. - Person: Jie Zheng, Chris Stoeckert, Alan Ruttenberg - Person: Jie Zheng, Chris Stoeckert, Alan Ruttenberg IAO:0000233 external uberon @@ -179,9 +135,7 @@ We also have the outstanding issue of how to aim different definitions to differ true true term_tracker_item - The 'tracker item' can associate a tracker with a specific ontology term. term tracker item - term tracker item @@ -189,15 +143,7 @@ We also have the outstanding issue of how to aim different definitions to differ - expand expression to - ObjectProperty: RO_0002104 -Label: has plasma membrane part -Annotations: IAO_0000424 "http://purl.obolibrary.org/obo/BFO_0000051 some (http://purl.org/obo/owl/GO#GO_0005886 and http://purl.obolibrary.org/obo/BFO_0000051 some ?Y)" - - A macro expansion tag applied to an object property (or possibly a data property) which can be used by a macro-expansion engine to generate more complex expressions from simpler ones - Chris Mungall expand expression to - expand expression to @@ -229,16 +175,14 @@ Annotations: IAO_0000424 "http://purl.obolibrary.org/obo/BFO_0000051 some ( - has ontology root term - Ontology annotation property. Relates an ontology to a term that is a designated root term of the ontology. Display tools like OLS can use terms annotated with this property as the starting point for rendering the ontology class hierarchy. There can be more than one root. - Nicolas Matentzoglu IAO:0000700 + external uberon has_ontology_root_term + true true has_ontology_root_term has ontology root term - has ontology root term preferred_root @@ -253,14 +197,7 @@ Annotations: IAO_0000424 "http://purl.obolibrary.org/obo/BFO_0000051 some ( - term replaced by - - Use on obsolete terms, relating the term to another term that can be used as a substitute - Person:Alan Ruttenberg - Person:Alan Ruttenberg - Add as annotation triples in the granting ontology term replaced by - term replaced by @@ -1433,12 +1370,6 @@ WHERE { - - - - - - @@ -1503,6 +1434,12 @@ WHERE { + + + + + + @@ -2070,7 +2007,7 @@ A continuant cannot have an occurrent as part: use 'participates in'. An example is: translation preceded_by transcription; aging preceded_by development (not however death preceded_by aging). Where derives_from links classes of continuants, preceded_by links classes of processes. Clearly, however, these two relations are not independent of each other. Thus if cells of type C1 derive_from cells of type C, then any cell division involving an instance of C1 in a given lineage is preceded_by cellular processes involving an instance of C. The assertion P preceded_by P1 tells us something about Ps in general: that is, it tells us something about what happened earlier, given what we know about what happened later. Thus it does not provide information pointing in the opposite direction, concerning instances of P1 in general; that is, that each is such as to be succeeded by some instance of P. Note that an assertion to the effect that P preceded_by P1 is rather weak; it tells us little about the relations between the underlying instances in virtue of which the preceded_by relation obtains. Typically we will be interested in stronger relations, for example in the relation immediately_preceded_by, or in relations which combine preceded_by with a condition to the effect that the corresponding instances of P and P1 share participants, or that their participants are connected by relations of derivation, or (as a first step along the road to a treatment of causality) that the one process in some way affects (for example, initiates or regulates) the other. is preceded by preceded_by - http://www.obofoundry.org/ro/#OBO_REL:preceded_by + http://www.obofoundry.org/ro/#OBO_REL:preceded_by BFO:0000062 external uberon @@ -2502,24 +2439,6 @@ A continuant cannot have an occurrent as part: use 'participates in'. - - - - This document is about information artifacts and their representations - - A (currently) primitive relation that relates an information artifact to an entity. - 7/6/2009 Alan Ruttenberg. Following discussion with Jonathan Rees, and introduction of "mentions" relation. Weaken the is_about relationship to be primitive. - -We will try to build it back up by elaborating the various subproperties that are more precisely defined. - -Some currently missing phenomena that should be considered "about" are predications - "The only person who knows the answer is sitting beside me" , Allegory, Satire, and other literary forms that can be topical without explicitly mentioning the topic. - person:Alan Ruttenberg - Smith, Ceusters, Ruttenberg, 2000 years of philosophy - is about - - - - @@ -2600,7 +2519,7 @@ Some currently missing phenomena that should be considered "about" are a relation between a process and a continuant, in which the continuant is somehow involved in the process Has_participant is a primitive instance-level relation between a process, a continuant, and a time at which the continuant participates in some way in the process. The relation obtains, for example, when this particular process of oxygen exchange across this particular alveolar membrane has_participant this particular sample of hemoglobin at this particular time. has_participant - http://www.obofoundry.org/ro/#OBO_REL:has_participant + http://www.obofoundry.org/ro/#OBO_REL:has_participant RO:0000057 external has_participant @@ -2783,43 +2702,18 @@ Some currently missing phenomena that should be considered "about" are - - - - - - - - - - - contained in - Containment is location not involving parthood, and arises only where some immaterial continuant is involved. - Containment obtains in each case between material and immaterial continuants, for instance: lung contained_in thoracic cavity; bladder contained_in pelvic cavity. Hence containment is not a transitive relation. If c part_of c1 at t then we have also, by our definition and by the axioms of mereology applied to spatial regions, c located_in c1 at t. Thus, many examples of instance-level location relations for continuants are in fact cases of instance-level parthood. For material continuants location and parthood coincide. Containment is location not involving parthood, and arises only where some immaterial continuant is involved. To understand this relation, we first define overlap for continuants as follows: c1 overlap c2 at t =def for some c, c part_of c1 at t and c part_of c2 at t. The containment relation on the instance level can then be defined (see definition): - Intended meaning: -domain: material entity -range: spatial region or site (immaterial continuant) - - contained_in - - - contained in - - - - contains - RO:0001019 uberon contains - contains contains - contains + obsolete contains + + true @@ -2842,7 +2736,7 @@ range: spatial region or site (immaterial continuant) Most location relations will only hold at certain times, but this is difficult to specify in OWL. See http://purl.obolibrary.org/obo/ro/docs/temporal-semantics/ located_in - http://www.obofoundry.org/ro/#OBO_REL:located_in + http://www.obofoundry.org/ro/#OBO_REL:located_in RO:0001025 uberon located_in @@ -6918,16 +6812,6 @@ For example, A and B may be gene products and binding of B by A positively regul - - - - A relationship that holds between two entities, where the entities exhibit a statistical dependence relationship. The entities may be statistical variables, or they may be other kinds of entities such as diseases, chemical entities or processes. - Groups both positive and negative correlation - correlated with - - - - @@ -7457,27 +7341,13 @@ For example, A and B may be gene products and binding of B by A positively regul A diagnostic testing device utilizes a specimen means that the diagnostic testing device is capable of an assay, and this assay a specimen as its input. See github ticket https://github.com/oborel/obo-relations/issues/497 - 2021-11-08T12:00:00Z + 2021-11-08T12:00:00Z utilizes device utilizes material - - - - - - - A relation between entities in which one increases or decreases as the other does the same. - directly correlated with - - positively correlated with - - - - @@ -8152,7 +8022,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + @@ -8168,7 +8038,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process multicellular anatomical structure - + @@ -8180,7 +8050,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + There is a cost to burying this in PATO. We lose that we could relax the cardinality assertion to subClassOf has_part some cell. I'm sure having this axiom inherited would come in handy. DOS @@ -8229,6 +8099,43 @@ MH: sexual subtypes should probably be logically defined based on sexual process + + + + Any molecular entity that contains carbon. + chebi_ontology + organic compounds + organic entity + organic molecular entities + CHEBI:50860 + + + + + Any molecular entity that contains carbon. + ANON:ANON + + + + + organic compounds + ChEBI: + + + + + organic entity + ChEBI: + + + + + organic molecular entities + ChEBI: + + + + @@ -8533,9 +8440,9 @@ MH: sexual subtypes should probably be logically defined based on sexual process FMA:86475 MESH:D006412 VHOG:0001485 - HSC blood forming stem cell hemopoietic stem cell + HSC colony forming unit hematopoietic @@ -8552,6 +8459,12 @@ MH: sexual subtypes should probably be logically defined based on sexual process PMID:19022770 http://en.wikipedia.org/wiki/Hematopoietic_stem_cell + + + + HSC + + @@ -8670,6 +8583,12 @@ MH: sexual subtypes should probably be logically defined based on sexual process http://en.wikipedia.org/wiki/Monoblast http://www.copewithcytokines.de + + + + CFU-M + + @@ -8725,10 +8644,10 @@ MH: sexual subtypes should probably be logically defined based on sexual process A progenitor cell committed to myeloid lineage, including the megakaryocyte and erythroid lineages. BTO:0004730 - CMP common myeloid precursor CFU-GEMM CFU-S + CMP colony forming unit granulocyte, erythrocyte, macrophage, and megakaryocyte multipotential myeloid stem cell myeloid stem cell @@ -8753,21 +8672,24 @@ MH: sexual subtypes should probably be logically defined based on sexual process - - CMP + + CFU-GEMM ISBN:0878932437 + - CFU-GEMM + CFU-S ISBN:0878932437 + - CFU-S + CMP ISBN:0878932437 + @@ -8820,10 +8742,10 @@ MH: sexual subtypes should probably be logically defined based on sexual process A oligopotent progenitor cell committed to the lymphoid lineage. - CLP common lymphocyte precursor common lymphocyte progenitor common lymphoid precursor + CLP ELP committed lymphopoietic stem cell early lymphocyte progenitor @@ -8849,6 +8771,18 @@ MH: sexual subtypes should probably be logically defined based on sexual process PMID:10407577 PMID:16551251 + + + + CLP + + + + + + ELP + + @@ -8971,6 +8905,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process epithelial cell + https://www.swissbiopics.org/api/image/Epithelial_cells.svg @@ -9501,10 +9436,10 @@ MH: sexual subtypes should probably be logically defined based on sexual process BTO:0002625 BTO:0003298 FMA:70546 - BMSC bone marrow stromal cells colony-forming unit-fibroblast marrow stromal cells + BMSC CFU-F MSC mesenchymal precursor cell @@ -9543,11 +9478,24 @@ MH: sexual subtypes should probably be logically defined based on sexual process marrow stromal cells PMID:11378515 + + + + BMSC + + + + + + CFU-F + + MSC PMID:11378515 + @@ -9625,7 +9573,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process A cell capable of processing and presenting lipid and protein antigens to T cells in order to initiate an immune response. - APC + APC Note change of name; nearly all somatic cells can present antigens to T cells via MHC Class I complexes leading to effector responses, but professional antigen presenting cells constitutively express MHC Class II as well as costimulatory molecules, and thus can initiate immune responses via T cells. professional antigen presenting cell @@ -9637,6 +9585,12 @@ MH: sexual subtypes should probably be logically defined based on sexual process GOC:add ISBN:0781735149 + + + + APC + + @@ -9906,6 +9860,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process muscle fiber myocyte muscle cell + https://www.swissbiopics.org/api/image/Muscle_cells.svg @@ -10068,6 +10023,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process CALOHA:TS-0868 FMA:86740 photoreceptor cell + https://www.swissbiopics.org/api/image/Photoreceptor_cell.svg @@ -10515,7 +10471,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process A cell derived from the specialized ectoderm flanking each side of the embryonic neural plate, which after the closure of the neural tube, forms masses of cells that migrate out from the dorsal aspect of the neural tube to spread throughout the body. - MESH:A16.254.600 + doi:10.1016/j.stem.2015.02.017 @@ -11055,6 +11011,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process These cells are also reportedly CD4-negative and CD200-positive. They are also capable of producing CD40L and IFN-gamma. neuron + https://www.swissbiopics.org/api/image/Neuron_cells.svg @@ -11194,6 +11151,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process metazoan cell animal cell + https://www.swissbiopics.org/api/image/Animal_cells.svg @@ -11290,12 +11248,12 @@ MH: sexual subtypes should probably be logically defined based on sexual process A hematopoietic progenitor cell that is committed to the granulocyte and monocyte lineages. These cells are CD123-positive, and do not express Gata1 or Gata2 but do express C/EBPa, and Pu.1. CFU-C , Colony forming unit in culture - CFU-GM - GMP colony forming unit granulocyte macrophage granulocyte-macrophage progenitor granulocyte/monocyte precursor granulocyte/monocyte progenitor + CFU-GM + GMP Originally described in the dendritic cell ontology (DC_CL:0000042)(PMID:19243617). GMPs are reportedly CD16-positive, CD32-positive, CD34-positive, CD38-positive, CD45RA-positive, CD110-negative, CD117-positive, CD123-positive, and SCA1-negative. granulocyte monocyte progenitor cell @@ -11326,7 +11284,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - CFU-GM + colony forming unit granulocyte macrophage ISBN:0721601464 PMCID:PMC2213186 PMCID:PMC548021 @@ -11334,26 +11292,28 @@ MH: sexual subtypes should probably be logically defined based on sexual process - GMP + granulocyte-macrophage progenitor ISBN:0721601464 PMCID:PMC2213186 PMCID:PMC548021 - - colony forming unit granulocyte macrophage + + CFU-GM ISBN:0721601464 PMCID:PMC2213186 PMCID:PMC548021 + - - granulocyte-macrophage progenitor + + GMP ISBN:0721601464 PMCID:PMC2213186 PMCID:PMC548021 + @@ -12256,24 +12216,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process Most markers only described for human pro NK cells. pro-NK cell - - - - null cell - PMID:11532393 - - - - - preNK cell - PMID:11532393 - - - - - - true - @@ -12294,6 +12236,24 @@ MH: sexual subtypes should probably be logically defined based on sexual process PMID:15032583 PMID:15766674 + + + + null cell + PMID:11532393 + + + + + preNK cell + PMID:11532393 + + + + + + true + @@ -15763,32 +15723,32 @@ MH: sexual subtypes should probably be logically defined based on sexual process - - + + A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures. Wikipedia:Collagen cellular_component GO:0005581 collagen trimer - + - + - + PMID:12382326 - + PMID:12382326 @@ -17149,6 +17109,102 @@ MH: sexual subtypes should probably be logically defined based on sexual process + + + + + The multiplication or reproduction of cells, resulting in the expansion of a cell population. + + biological_process + cell proliferation + GO:0008283 + + + + + + + This term was moved out from being a child of 'cellular process' because it is a cell population-level process, and cellular processes are restricted to those processes that involve individual cells. Also note that this term is intended to be used for the proliferation of cells within a multicellular organism, not for the expansion of a population of single-celled organisms. + cell population proliferation + + + + + The multiplication or reproduction of cells, resulting in the expansion of a cell population. + GOC:mah + GOC:mb + + + + + + + + + The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. + jl + 2012-10-17T15:52:18Z + GO:0044274 + GO:0044711 + formation + Wikipedia:Anabolism + anabolism + biosynthesis + synthesis + multicellular organismal biosynthetic process + biological_process + single-organism biosynthetic process + GO:0009058 + + + + biosynthetic process + + + + + The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. + GOC:curators + ISBN:0198547684 + + + + + + + + + + + The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. + https://github.com/geneontology/go-ontology/issues/15249 + https://github.com/geneontology/go-ontology/issues/25418 + GO:0043284 + biopolymer biosynthetic process + macromolecule anabolism + macromolecule biosynthesis + macromolecule formation + macromolecule synthesis + biological_process + GO:0009059 + + macromolecule biosynthetic process + + + + + The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. + GOC:mah + + + + + biopolymer biosynthetic process + GOC:mtg_chebi_dec09 + + + + @@ -17608,9 +17664,10 @@ MH: sexual subtypes should probably be logically defined based on sexual process - - The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, translation and maturation for protein-coding genes. + + The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, as well as translation and maturation for protein-coding genes. https://github.com/geneontology/go-ontology/issues/22557 + https://github.com/geneontology/go-ontology/issues/25419 Wikipedia:Gene_expression biological_process GO:0010467 @@ -17620,7 +17677,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, translation and maturation for protein-coding genes. + The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, as well as translation and maturation for protein-coding genes. GOC:txnOH-2018 PMID:25934543 PMID:31580950 @@ -18493,6 +18550,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process + @@ -20401,6 +20459,58 @@ MH: sexual subtypes should probably be logically defined based on sexual process + + + + + + The chemical reactions and pathways by which individual cells transform chemical substances. + cellular metabolism + biological_process + intermediary metabolism + GO:0044237 + + This term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term. + cellular metabolic process + + + + + The chemical reactions and pathways by which individual cells transform chemical substances. + GOC:go_curators + + + + + intermediary metabolism + GOC:mah + + + + + + + + + + The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. + cellular anabolism + cellular biosynthesis + cellular formation + cellular synthesis + biological_process + GO:0044249 + cellular biosynthetic process + + + + + The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. + GOC:jl + + + + @@ -22483,6 +22593,46 @@ MH: sexual subtypes should probably be logically defined based on sexual process + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways involving an organic substance, any molecular entity containing carbon. + mah + 2010-03-08T03:32:18Z + organic molecular entity metabolic process + organic molecular entity metabolism + organic substance metabolism + biological_process + GO:0071704 + organic substance metabolic process + + + + + The chemical reactions and pathways involving an organic substance, any molecular entity containing carbon. + GOC:mah + + + + @@ -23448,6 +23598,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process + A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex but below that of an anatomical system. Or, a substance produced by a cellular organism with granularity above the level of a protein complex. kmv 2019-08-12T18:01:37Z @@ -23628,6 +23779,78 @@ MH: sexual subtypes should probably be logically defined based on sexual process + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways resulting in the formation of an organic substance, any molecular entity containing carbon. + pr + 2012-11-05T11:04:40Z + organic molecular entity anabolism + organic molecular entity biosynthesis + organic molecular entity biosynthetic process + organic molecular entity formation + organic molecular entity synthesis + organic substance anabolism + organic substance biosynthesis + organic substance formation + organic substance synthesis + biological_process + GO:1901576 + organic substance biosynthetic process + + + + + The chemical reactions and pathways resulting in the formation of an organic substance, any molecular entity containing carbon. + GOC:TermGenie + GOC:pr + + + + + organic molecular entity anabolism + GOC:TermGenie + + + + + organic molecular entity biosynthesis + GOC:TermGenie + + + + + organic molecular entity formation + GOC:TermGenie + + + + + organic molecular entity synthesis + GOC:TermGenie + + + + @@ -28206,8 +28429,8 @@ MH: sexual subtypes should probably be logically defined based on sexual process - - + + @@ -28258,11 +28481,11 @@ MH: sexual subtypes should probably be logically defined based on sexual process tendon http://upload.wikimedia.org/wikipedia/commons/3/3c/Achilles-tendon.jpg - + - + @@ -28275,13 +28498,13 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + OG - + AEO @@ -29272,7 +29495,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + @@ -29308,14 +29531,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process gastrula stage - + - + BILS @@ -29536,7 +29759,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + @@ -29609,7 +29832,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process https://github.com/obophenotype/uberon/issues/661 http://upload.wikimedia.org/wikipedia/commons/0/06/Mouth_illustration-Otis_Archives.jpg - + @@ -29622,7 +29845,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + exceptions in some taxa @@ -29931,7 +30154,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + @@ -29973,14 +30196,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process organism substance - + - + this relationship may be too strong and may be weakened in future @@ -31212,7 +31435,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + Primary germ layer that is the outer of the embryo's three germ layers and gives rise to epidermis and neural tissue. Primary germ layer that is the outer of the embryonic germ layers and gives rise to epidermis and neural tissue.[AAO] The Bilateria are triploblastic (with true endoderm, mesoderm, and ectoderm) (...).[well established][VHOG] @@ -31250,14 +31473,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process ectoderm http://upload.wikimedia.org/wikipedia/commons/1/19/Gray32.png - + - + Bgee:AN @@ -31310,7 +31533,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + Primary germ layer that lies remote from the surface of the embryo and gives rise to internal tissues such as gut. The Bilateria are triploblastic (with true endoderm, mesoderm, and ectoderm) (...).[well established][VHOG] endodermal @@ -31347,14 +31570,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process http://upload.wikimedia.org/wikipedia/commons/c/c0/Endoderm2.png http://upload.wikimedia.org/wikipedia/commons/d/df/Gray10.png - + - + Bgee:AN @@ -31399,7 +31622,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + The middle germ layer of the embryo, between the endoderm and ectoderm. Primary germ layer that is the middle of the embryonic germ layers.[AAO] @@ -31444,7 +31667,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process mesoderm http://upload.wikimedia.org/wikipedia/commons/e/e8/Mesoderm.png - + @@ -31457,7 +31680,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + Bgee:AN @@ -31780,8 +32003,8 @@ MH: sexual subtypes should probably be logically defined based on sexual process - - + + @@ -31817,24 +32040,24 @@ MH: sexual subtypes should probably be logically defined based on sexual process eye - + - + - + PMID:21062451 - + PMID:21062451 @@ -32441,7 +32664,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + @@ -32496,14 +32719,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process http://upload.wikimedia.org/wikipedia/commons/b/b2/TE-Nervous_system_diagram.svg http://upload.wikimedia.org/wikipedia/commons/b/ba/Nervous_system_diagram.png - + - + Bgee:AN @@ -32591,7 +32814,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the neural tube derivatives: the brain and spinal cord. In invertebrates it includes central ganglia plus nerve cord. Part of the nervous system which includes the brain and spinal cord.[AAO] @@ -32638,7 +32861,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process central nervous system - + @@ -32652,7 +32875,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + Bgee:AN @@ -33519,7 +33742,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + Skeletal element that is composed of bone tissue. @@ -33569,14 +33792,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process bone element - + - + VSAO-modified @@ -33687,7 +33910,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + A tube extending from the mouth to the anus. @@ -33727,14 +33950,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process digestive tract - + - + NCBIBook:NBK10107 @@ -34325,7 +34548,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + @@ -34361,14 +34584,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process musculoskeletal system - + - + check ctenophore @@ -34431,9 +34654,9 @@ MH: sexual subtypes should probably be logically defined based on sexual process - - - + + + @@ -34488,15 +34711,15 @@ MH: sexual subtypes should probably be logically defined based on sexual process notochord http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png - + - + - + @@ -34515,19 +34738,19 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + http://tolweb.org/Chordata/2499 - + ZFA - + EHDAA2 @@ -34612,8 +34835,8 @@ MH: sexual subtypes should probably be logically defined based on sexual process - - + + Somites are spheres of epithelial cells that form sequentially along the anterior-posterior axis of the embryo through mesenchymal to epithelial transition of the presomitic mesoderm. currently classified as an epithelial vesicle, consistent with EHDAA2 and https://github.com/obophenotype/uberon/wiki/The-neural-crest. Consider making 'somitic mesoderm' a separate term and correlate with regionalization processes. Consider moving ZFA term to 'trunk somite' as it is part of the trunk @@ -34659,11 +34882,11 @@ MH: sexual subtypes should probably be logically defined based on sexual process somite http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png - + - + @@ -34676,13 +34899,13 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + GOTAX:0000352 - + ZFA @@ -34859,12 +35082,12 @@ MH: sexual subtypes should probably be logically defined based on sexual process - - - - - - + + + + + + A specialized region of ectoderm found between the neural ectoderm (neural plate) and non-neural ectoderm and composed of highly migratory pluripotent cells that delaminate in early embryonic development from the dorsal neural tube and give rise to an astounding variety of differentiated cell types[MP]. consider including subclasses for pre- and post- migratory (e.g. sheets/paths/streams). @@ -34904,66 +35127,66 @@ MH: sexual subtypes should probably be logically defined based on sexual process http://upload.wikimedia.org/wikipedia/commons/5/5f/Gray644.png https://upload.wikimedia.org/wikipedia/commons/8/8f/Neural_Crest.png - + - + - + - + - + - + - + XAO https://github.com/obophenotype/uberon/wiki/The-neural-crest - + Hall and others restrict NC to vertebrates but we opt for a less restrictive constraint to avoid inconsistencies when areas such as P1 area of pallium in hagfishes inherit cell lineage from telecephalon-contributing NC cells ISBN:0073040584 - + BTO - + PMID:11523831 - + pre migratory https://github.com/obophenotype/uberon/wiki/The-neural-crest - + PMID:11523831 @@ -35318,7 +35541,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + @@ -35376,14 +35599,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process bone marrow http://upload.wikimedia.org/wikipedia/commons/7/74/Gray72-en.svg - + - + FMA MA @@ -35654,14 +35877,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + - + Anatomical system that is involved in the production of hematopoietic cells. @@ -35705,24 +35928,24 @@ MH: sexual subtypes should probably be logically defined based on sexual process hematopoietic system - + - + - + FMA - + definitional @@ -36188,7 +36411,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + Unsegmented field of paraxial mesoderm present posterior to the most recently formed somite pair, from which somites will form. Unsegmented field of paraxial mesoderm present posterior to the most recently formed somite pair, from which somites will form. Kimmel et al, 1995.[TAO] It is reasonable to assume that the proximate invertebrate ancestor of the vertebrates had an amphioxus-like tail bud in its larval stage. This archetypal tail bud would have (...) (3) lacked any component of mesenchyme cells, (4) budded off new mesodermal segments directly, without any intervening zone of presomitic mesoderm (...). Then, early in vertebrate evolution, epithelium-to-mesenchyme interconversions (and the gene networks for effecting them) became prominent features of development. (...) In any case, conspicuous mesenchymal components tended to be added to the vertebrate tail bud itself. In addition, a mesenchymatous presomitic mesoderm (not a part of the tail bud proper) came to intervene between the tail bud and the forming somites.[well established][VHOG] @@ -36213,14 +36436,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process presomitic mesoderm - + - + Bgee:AN @@ -36450,9 +36673,9 @@ MH: sexual subtypes should probably be logically defined based on sexual process - - - + + + A region of embryonic ectodermal cells that lie directly above the notochord. During neurulation, they change shape and produce an infolding of the neural plate (the neural fold) that then seals to form the neural tube[XAO]. The earliest recognizable dorsal ectodermal primordium of the central nervous system present near the end of gastrulation before infolding to form the neural keel; consists of a thickened pseudostratified epithelium[ZFA]. The earliest recognizable dorsal ectodermal primordium of the central nervous system present near the end of gastrulation before infolding to form the neural keel; consists of a thickened pseudostratified epithelium. Kimmel et al, 1995.[TAO] (...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...).[well established][VHOG] @@ -36484,34 +36707,34 @@ MH: sexual subtypes should probably be logically defined based on sexual process neural plate https://upload.wikimedia.org/wikipedia/commons/8/8f/Neural_Crest.png - + - + - + - + GOTAX:0000352 - + Wikipedia - + Bgee:AN @@ -36576,7 +36799,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + The paraxial mesoderm is the mesoderm located bilaterally adjacent to the notochord and neural tube[GO]. Mesoderm lateral to the neural tube and notochord that is divided into cranial and post-cranial portions. The trunk portions further segment into somites.[AAO] Presently, Cephalochordata, Urochordata, and Vertebrata are placed as subphyla of the phylum Chordata, in which the overall organization of embryonic tissues (dorsal hollow nerve cord, ventral digestive tract, axial notochord, and bilateral paraxial mesoderm) is largely conserved. In contrast, the echinoderms and hemichordates are sister groups of the chordates and they lack the notochord and paraxial mesoderm. Thus, the basic mesodermal organization of vertebrates must have appeared first in the common ancestor of the chordates.[well established][VHOG] @@ -36605,7 +36828,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process paraxial mesoderm http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png - + @@ -36618,7 +36841,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + Bgee:AN @@ -36690,7 +36913,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + @@ -36734,7 +36957,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process lateral plate mesoderm http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png - + @@ -36747,7 +36970,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + EHDAA2 VHOG @@ -36831,7 +37054,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + @@ -36874,7 +37097,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process myotome http://upload.wikimedia.org/wikipedia/commons/9/96/Gray65.png - + @@ -36887,7 +37110,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + EHDAA2-abduced @@ -36943,8 +37166,8 @@ MH: sexual subtypes should probably be logically defined based on sexual process - - + + Ventral somitic compartment that is a precursor of the axial skeleton[XAO]. Sclerotomes eventually differentiate into the vertebrae and most of the skull. The caudal (posterior) half of one sclerotome fuses with the rostral (anterior) half of the adjacent one to form each vertebra. From their initial location within the somite, the sclerotome cells migrate medially towards the notochord. These cells meet the sclerotome cells from the other side to form the vertebral body. From this vertebral body, sclerotome cells move dorsally and surround the developing spinal cord, forming the vertebral arch[WP]. Skeletogenic portion of somites.[AAO] The vertebrate sclerotome has no equivalent in amphioxus and is a novelty linked with the evolution of the axial skeleton.[well established][VHOG] @@ -36971,11 +37194,11 @@ MH: sexual subtypes should probably be logically defined based on sexual process sclerotome http://upload.wikimedia.org/wikipedia/commons/9/96/Gray65.png - + - + @@ -36994,13 +37217,13 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + VHOG:0000680 - + ZFA @@ -37209,7 +37432,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + The part of the coelom in the embryo between the somatopleuric and splanchnopleuric mesoderm; the principal body cavities of the trunk (thoracic, abdominal, and pelvic) arise from this embryonic part of the coelom. consider merging with coelom. TODO - add spatial relationships to halves of LPM. Note the OG places XAO and ZFA coelem terms here. editor note: TODO check ZFA, which appears to be a structure present in adults (...) I regard it unlikely that coeloms of all bilaterian animals are comparable and evolved very early. Considering all these questions, few convincing characters concerning the evolution of body cavities remain to be named. (...) A segmental coelom appears to have evolved at least two times, in Annelida and in Myomerata (Acrania and Craniota).[well established][VHOG] @@ -37225,14 +37448,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process intraembryonic coelom - + - + Wikipedia @@ -37560,7 +37783,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + The bilaminar epithelium formed from the myotome and dermatome. Epithelial sheet on the external surface of the somite that gives rise to trunk, muscle and dermis. Within the dermomyotome there is also a medio-lateral difference. The central region makes dermis, the mesenchymal connective tissue of the back skin. The medial region (closest to neural tube) makes epaxial muscle, and the lateral region (furthest from neural tube) makes hypaxial muscle[http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=eurekah&part=A66768]. Epithelial sheet on the external surface of the somite that gives rise to trunk, muscle and dermis.[TAO] @@ -37583,7 +37806,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process UBERON:0004290 dermomyotome - + @@ -37602,7 +37825,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + EHDAA2 ZFA @@ -37928,7 +38151,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + A specialized form of connective tissue in which the extracellular matrix is firm, providing the tissue with resilience, and/or mineralized and that functions in mechanical and structural support.[VSAO]. A specialized form of connective tissue in which the extracellular matrix is firm, providing the tissue with resilience, and/or mineralized and that functions in mechanical and structural support.[VSAO] EMAPA:37744 @@ -37942,7 +38165,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process Four classes of mineralized tissues are found in vertebrates: bone, cartilage, dentine, and enamel. We think of cartilage and bone as skeletal tissues and of enamel and dentine as dental tissues, but enamel and dentine arose evolutionarily together with bone as skeletal tissues in the dermal skeleton (exoskeleton) of early vertebrates. Scales and teeth of sharks are examples of dermal skeletal elements that are still composed of the three ancient components-enamel, dentine, and bone. Cartilage, on the other hand, provided the basis for the second vertebrate skeletal system, the endoskeleton (Smith and Hall, 1990; Hall, 1998a,b). some invertebrate skeletal tissues have surprisingly bone-like features. Examples include chondrocytes interconnected by cell processes in cephalopod cartilages (Cole and Hall, 2004a,b), and the calcium phosphate layer in the shells of brachiopods (Rodland et al., 2003). However, neither bone nor mineralized cartilage have been found in invertebrates. Editors notes: TODO - develops_from skeletal tissue - + @@ -37955,7 +38178,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + 2012-08-14 VSAO:0000015 VSAO @@ -37994,7 +38217,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + Organ consisting of skeletal tissue. Encompasses whole bones, fused bones, cartilaginious elements, teeth, dermal denticles. Organ entity that is typically involved in mechanical support and may have different skeletal tissue compositions at different stages.[VSAO] Organ entity that may have different tissue compositions at different stages and is typically involved in mechanical support.[TAO] @@ -38010,14 +38233,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process skeletal element - + - + VSAO @@ -38062,7 +38285,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + @@ -38101,14 +38324,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process UBERON:0004770 articular system - + - + FMA @@ -38575,7 +38798,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + Mesenchyme that is part of a developing trunk. EFO:0003485 EHDAA2:0002092 @@ -38591,14 +38814,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process trunk mesenchyme - + - + EHDAA2 @@ -38895,7 +39118,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + A delimited region of dense mesenchyme within looser mesenchyme. AEO:0000148 EHDAA2_RETIRED:0003148 @@ -38905,7 +39128,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process UBERON:0005856 developing mesenchymal condensation - + @@ -38924,7 +39147,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + AEO-modified-relation @@ -39029,7 +39252,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + The notochordal plate is the dorsal part of the notochordal process when the ventral portion breaks down. It is continuous laterally with the endoderm that composes the roof of the primitive foregut and is in contact dorsally with the neural tube. The folding off of the notochordal plate gives rise to the notochord. TODO - check ordering; awaiting confirmation from JB The notochordal plate is the dorsal part of the notochordal process when the ventral portion breaks down. It is continuous laterally with the endoderm that composes the roof of the primitive foregut and is in contact dorsally with the neural tube. The folding off of the notochordal plate gives rise to the notochord. [Carson_JL, Dehart_DB, Developmental_Dynamics_(1994)_201:_260-278, Gesteland_K_and_Schoenwolf_GC, Inagaki_T, Morphogenesis_of_the_murine_node_and_notochordal_plate, The_prechordal_plate, Vrablic_T, see_Mueller_F_and_O'Rahilly_R, the_rostral_end_of_the_notochord_and_nearby_median_features_in_staged_human_embryos._Cells_Tissues_Organs_(2003)_173:_1-20_and_Sulik_K][VHOG] @@ -39044,7 +39267,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process notochordal plate - + @@ -39057,7 +39280,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + EHDAA2 @@ -39094,7 +39317,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + A midline cellular cord formed from the migration of mesenchymal cells from the primitive knot. EHDAA2:0001279 EHDAA:224 @@ -39111,14 +39334,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process The notochordal process grows cranially until it reaches the prechordal plate, the future site of the mouth. In this area the ectoderm is attached directly to the endoderm without intervening mesoderm. This area is known as the oropharyngeal membrane, and it will break down to become the mouth. At the other end of the primitive streak the ectoderm is also fused directly to the endoderm; this is known as the cloacal membrane (proctodeum), or primordial anus. notochordal process - + - + EHDAA2 @@ -39576,7 +39799,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + A hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood or analogs[GO,modified]. note we reserve the subclass 'heart' from the vertebrate multi-chambered heart. 'The first heart-like organ is believed to have appeared 500my ago in an ancestral bilaterian'. Amniotes: four-chambered heart. Amphibians: two atria, one ventricle, pulmonary; fish: single atrium and ventricle; amphioxus: tubular, non-striated, closed, unidirectional; ascidians: tubular, striated, open, bidirectional; arthropods: tubular, open; C elegans: contractile pharynx; Cnideria: striated muscle cells associated with gastrodermis SPD:0000130 @@ -39591,14 +39814,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process Gene notes: Bmp, Nkx, Gata primary circulatory organ - + - + GO uses blood circulation generically to include the haemolymphatic fluid of arthropods @@ -39688,7 +39911,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + @@ -39705,14 +39928,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process presumptive segmental plate - + - + https://github.com/obophenotype/uberon/wiki/The-neural-crest EDHAA2 @@ -39811,7 +40034,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + @@ -39837,7 +40060,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process presumptive paraxial mesoderm - + @@ -39853,7 +40076,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + https://github.com/obophenotype/uberon/issues/1277 @@ -39902,7 +40125,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + Mesenchyme with little extracellular matrix. AEO:0000146 EHDAA2:0003146 @@ -39910,7 +40133,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process UBERON:0007524 dense mesenchyme tissue - + @@ -39923,7 +40146,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + AEO @@ -40233,7 +40456,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + @@ -40250,14 +40473,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process UBERON:0009142 entire embryonic mesenchyme - + - + EHDAA2 @@ -40279,7 +40502,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + EHDAA2:0002094 trunk and cervical paraxial mesenchyme uberon @@ -40287,14 +40510,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process UBERON:0009618 trunk paraxial mesoderm - + - + EHDAA2 @@ -40454,8 +40677,8 @@ MH: sexual subtypes should probably be logically defined based on sexual process - - + + Anatomical cluster consisting of the skeletal elements (i.e. bone elements, cartilage elements, cartilage condensations) that are part of an individual subdivision of the organism. Excludes joints. Anatomical cluster consisting of the skeletal elements that are part of the skeleton.[VSAO] FMA:23879 @@ -40468,11 +40691,11 @@ MH: sexual subtypes should probably be logically defined based on sexual process subdivision of skeleton - + - + @@ -40485,13 +40708,13 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + UBERONREF:0000003 - + VSAO @@ -40862,7 +41085,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + @@ -40887,7 +41110,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process UBERON:0011899 epimysium - + @@ -40900,7 +41123,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + FMA @@ -41006,7 +41229,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + @@ -41028,7 +41251,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process UBERON:0012429 hematopoietic tissue - + @@ -41041,7 +41264,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + defitional @@ -41609,7 +41832,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + @@ -41632,7 +41855,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process UBERON:0016887 entire extraembryonic component - + @@ -41645,7 +41868,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + AEO @@ -41731,7 +41954,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + @@ -41747,14 +41970,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process skeletal musculature - + - + MA @@ -42042,196 +42265,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process - - - - - - - - - example to be eventually removed - example to be eventually removed - - - - - - - - failed exploratory term - The term was used in an attempt to structure part of the ontology but in retrospect failed to do a good job - Person:Alan Ruttenberg - failed exploratory term - - - - - - - - metadata complete - Class has all its metadata, but is either not guaranteed to be in its final location in the asserted IS_A hierarchy or refers to another class that is not complete. - metadata complete - - - - - - - - organizational term - Term created to ease viewing/sort terms for development purpose, and will not be included in a release - organizational term - - - - - - - - ready for release - Class has undergone final review, is ready for use, and will be included in the next release. Any class lacking "ready_for_release" should be considered likely to change place in hierarchy, have its definition refined, or be obsoleted in the next release. Those classes deemed "ready_for_release" will also derived from a chain of ancestor classes that are also "ready_for_release." - ready for release - - - - - - - - metadata incomplete - Class is being worked on; however, the metadata (including definition) are not complete or sufficiently clear to the branch editors. - metadata incomplete - - - - - - - - uncurated - Nothing done yet beyond assigning a unique class ID and proposing a preferred term. - uncurated - - - - - - - - pending final vetting - All definitions, placement in the asserted IS_A hierarchy and required minimal metadata are complete. The class is awaiting a final review by someone other than the term editor. - pending final vetting - - - - - - - - placeholder removed - placeholder removed - - - - - - - - terms merged - An editor note should explain what were the merged terms and the reason for the merge. - terms merged - - - - - - - - term imported - This is to be used when the original term has been replaced by a term imported from an other ontology. An editor note should indicate what is the URI of the new term to use. - term imported - - - - - - - - term split - This is to be used when a term has been split in two or more new terms. An editor note should indicate the reason for the split and indicate the URIs of the new terms created. - term split - - - - - - - - universal - Hard to give a definition for. Intuitively a "natural kind" rather than a collection of any old things, which a class is able to be, formally. At the meta level, universals are defined as positives, are disjoint with their siblings, have single asserted parents. - Alan Ruttenberg - A Formal Theory of Substances, Qualities, and Universals, http://ontology.buffalo.edu/bfo/SQU.pdf - universal - - - - - - - - defined class - A defined class is a class that is defined by a set of logically necessary and sufficient conditions but is not a universal - "definitions", in some readings, always are given by necessary and sufficient conditions. So one must be careful (and this is difficult sometimes) to distinguish between defined classes and universal. - Alan Ruttenberg - defined class - - - - - - - - named class expression - A named class expression is a logical expression that is given a name. The name can be used in place of the expression. - named class expressions are used in order to have more concise logical definition but their extensions may not be interesting classes on their own. In languages such as OWL, with no provisions for macros, these show up as actuall classes. Tools may with to not show them as such, and to replace uses of the macros with their expansions - Alan Ruttenberg - named class expression - - - - - - - - to be replaced with external ontology term - Terms with this status should eventually replaced with a term from another ontology. - Alan Ruttenberg - group:OBI - to be replaced with external ontology term - - - - - - - - requires discussion - A term that is metadata complete, has been reviewed, and problems have been identified that require discussion before release. Such a term requires editor note(s) to identify the outstanding issues. - Alan Ruttenberg - group:OBI - requires discussion - - - - - + + symbol + @@ -75,34 +77,7 @@ - definition - - The official definition, explaining the meaning of a class or property. Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions. - 2012-04-05: -Barry Smith - -The official OBI definition, explaining the meaning of a class or property: 'Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions' is terrible. - -Can you fix to something like: - -A statement of necessary and sufficient conditions explaining the meaning of an expression referring to a class or property. - -Alan Ruttenberg - -Your proposed definition is a reasonable candidate, except that it is very common that necessary and sufficient conditions are not given. Mostly they are necessary, occasionally they are necessary and sufficient or just sufficient. Often they use terms that are not themselves defined and so they effectively can't be evaluated by those criteria. - -On the specifics of the proposed definition: - -We don't have definitions of 'meaning' or 'expression' or 'property'. For 'reference' in the intended sense I think we use the term 'denotation'. For 'expression', I think we you mean symbol, or identifier. For 'meaning' it differs for class and property. For class we want documentation that let's the intended reader determine whether an entity is instance of the class, or not. For property we want documentation that let's the intended reader determine, given a pair of potential relata, whether the assertion that the relation holds is true. The 'intended reader' part suggests that we also specify who, we expect, would be able to understand the definition, and also generalizes over human and computer reader to include textual and logical definition. - -Personally, I am more comfortable weakening definition to documentation, with instructions as to what is desirable. - -We also have the outstanding issue of how to aim different definitions to different audiences. A clinical audience reading chebi wants a different sort of definition documentation/definition from a chemistry trained audience, and similarly there is a need for a definition that is adequate for an ontologist to work with. - PERSON:Daniel Schober - GROUP:OBI:<http://purl.obolibrary.org/obo/obi> - definition - definition @@ -110,19 +85,12 @@ We also have the outstanding issue of how to aim different definitions to differ - editor note - - An administrative note intended for its editor. It may not be included in the publication version of the ontology, so it should contain nothing necessary for end users to understand the ontology. - PERSON:Daniel Schober - GROUP:OBI:<http://purl.obofoundry.org/obo/obi> IAO:0000116 uberon editor_note true editor_note - editor note - editor note @@ -147,13 +115,7 @@ We also have the outstanding issue of how to aim different definitions to differ - - has obsolescence reason - Relates an annotation property to an obsolescence reason. The values of obsolescence reasons come from a list of predefined terms, instances of the class obsolescence reason specification. - PERSON:Alan Ruttenberg - PERSON:Melanie Courtot - has obsolescence reason - + @@ -166,12 +128,6 @@ We also have the outstanding issue of how to aim different definitions to differ - term tracker item - the URI for an OBI Terms ticket at sourceforge, such as https://sourceforge.net/p/obi/obi-terms/772/ - - An IRI or similar locator for a request or discussion of an ontology term. - Person: Jie Zheng, Chris Stoeckert, Alan Ruttenberg - Person: Jie Zheng, Chris Stoeckert, Alan Ruttenberg IAO:0000233 external uberon @@ -179,9 +135,7 @@ We also have the outstanding issue of how to aim different definitions to differ true true term_tracker_item - The 'tracker item' can associate a tracker with a specific ontology term. term tracker item - term tracker item @@ -189,15 +143,7 @@ We also have the outstanding issue of how to aim different definitions to differ - expand expression to - ObjectProperty: RO_0002104 -Label: has plasma membrane part -Annotations: IAO_0000424 "http://purl.obolibrary.org/obo/BFO_0000051 some (http://purl.org/obo/owl/GO#GO_0005886 and http://purl.obolibrary.org/obo/BFO_0000051 some ?Y)" - - A macro expansion tag applied to an object property (or possibly a data property) which can be used by a macro-expansion engine to generate more complex expressions from simpler ones - Chris Mungall expand expression to - expand expression to @@ -229,16 +175,14 @@ Annotations: IAO_0000424 "http://purl.obolibrary.org/obo/BFO_0000051 some ( - has ontology root term - Ontology annotation property. Relates an ontology to a term that is a designated root term of the ontology. Display tools like OLS can use terms annotated with this property as the starting point for rendering the ontology class hierarchy. There can be more than one root. - Nicolas Matentzoglu IAO:0000700 + external uberon has_ontology_root_term + true true has_ontology_root_term has ontology root term - has ontology root term preferred_root @@ -253,14 +197,7 @@ Annotations: IAO_0000424 "http://purl.obolibrary.org/obo/BFO_0000051 some ( - term replaced by - - Use on obsolete terms, relating the term to another term that can be used as a substitute - Person:Alan Ruttenberg - Person:Alan Ruttenberg - Add as annotation triples in the granting ontology term replaced by - term replaced by @@ -1433,12 +1370,6 @@ WHERE { - - - - - - @@ -1503,6 +1434,12 @@ WHERE { + + + + + + @@ -2070,7 +2007,7 @@ A continuant cannot have an occurrent as part: use 'participates in'. An example is: translation preceded_by transcription; aging preceded_by development (not however death preceded_by aging). Where derives_from links classes of continuants, preceded_by links classes of processes. Clearly, however, these two relations are not independent of each other. Thus if cells of type C1 derive_from cells of type C, then any cell division involving an instance of C1 in a given lineage is preceded_by cellular processes involving an instance of C. The assertion P preceded_by P1 tells us something about Ps in general: that is, it tells us something about what happened earlier, given what we know about what happened later. Thus it does not provide information pointing in the opposite direction, concerning instances of P1 in general; that is, that each is such as to be succeeded by some instance of P. Note that an assertion to the effect that P preceded_by P1 is rather weak; it tells us little about the relations between the underlying instances in virtue of which the preceded_by relation obtains. Typically we will be interested in stronger relations, for example in the relation immediately_preceded_by, or in relations which combine preceded_by with a condition to the effect that the corresponding instances of P and P1 share participants, or that their participants are connected by relations of derivation, or (as a first step along the road to a treatment of causality) that the one process in some way affects (for example, initiates or regulates) the other. is preceded by preceded_by - http://www.obofoundry.org/ro/#OBO_REL:preceded_by + http://www.obofoundry.org/ro/#OBO_REL:preceded_by BFO:0000062 external uberon @@ -2502,24 +2439,6 @@ A continuant cannot have an occurrent as part: use 'participates in'. - - - - This document is about information artifacts and their representations - - A (currently) primitive relation that relates an information artifact to an entity. - 7/6/2009 Alan Ruttenberg. Following discussion with Jonathan Rees, and introduction of "mentions" relation. Weaken the is_about relationship to be primitive. - -We will try to build it back up by elaborating the various subproperties that are more precisely defined. - -Some currently missing phenomena that should be considered "about" are predications - "The only person who knows the answer is sitting beside me" , Allegory, Satire, and other literary forms that can be topical without explicitly mentioning the topic. - person:Alan Ruttenberg - Smith, Ceusters, Ruttenberg, 2000 years of philosophy - is about - - - - @@ -2600,7 +2519,7 @@ Some currently missing phenomena that should be considered "about" are a relation between a process and a continuant, in which the continuant is somehow involved in the process Has_participant is a primitive instance-level relation between a process, a continuant, and a time at which the continuant participates in some way in the process. The relation obtains, for example, when this particular process of oxygen exchange across this particular alveolar membrane has_participant this particular sample of hemoglobin at this particular time. has_participant - http://www.obofoundry.org/ro/#OBO_REL:has_participant + http://www.obofoundry.org/ro/#OBO_REL:has_participant RO:0000057 external has_participant @@ -2783,43 +2702,18 @@ Some currently missing phenomena that should be considered "about" are - - - - - - - - - - - contained in - Containment is location not involving parthood, and arises only where some immaterial continuant is involved. - Containment obtains in each case between material and immaterial continuants, for instance: lung contained_in thoracic cavity; bladder contained_in pelvic cavity. Hence containment is not a transitive relation. If c part_of c1 at t then we have also, by our definition and by the axioms of mereology applied to spatial regions, c located_in c1 at t. Thus, many examples of instance-level location relations for continuants are in fact cases of instance-level parthood. For material continuants location and parthood coincide. Containment is location not involving parthood, and arises only where some immaterial continuant is involved. To understand this relation, we first define overlap for continuants as follows: c1 overlap c2 at t =def for some c, c part_of c1 at t and c part_of c2 at t. The containment relation on the instance level can then be defined (see definition): - Intended meaning: -domain: material entity -range: spatial region or site (immaterial continuant) - - contained_in - - - contained in - - - - contains - RO:0001019 uberon contains - contains contains - contains + obsolete contains + + true @@ -2842,7 +2736,7 @@ range: spatial region or site (immaterial continuant) Most location relations will only hold at certain times, but this is difficult to specify in OWL. See http://purl.obolibrary.org/obo/ro/docs/temporal-semantics/ located_in - http://www.obofoundry.org/ro/#OBO_REL:located_in + http://www.obofoundry.org/ro/#OBO_REL:located_in RO:0001025 uberon located_in @@ -6924,16 +6818,6 @@ For example, A and B may be gene products and binding of B by A positively regul - - - - A relationship that holds between two entities, where the entities exhibit a statistical dependence relationship. The entities may be statistical variables, or they may be other kinds of entities such as diseases, chemical entities or processes. - Groups both positive and negative correlation - correlated with - - - - @@ -7462,27 +7346,13 @@ For example, A and B may be gene products and binding of B by A positively regul A diagnostic testing device utilizes a specimen means that the diagnostic testing device is capable of an assay, and this assay a specimen as its input. See github ticket https://github.com/oborel/obo-relations/issues/497 - 2021-11-08T12:00:00Z + 2021-11-08T12:00:00Z utilizes device utilizes material - - - - - - - A relation between entities in which one increases or decreases as the other does the same. - directly correlated with - - positively correlated with - - - - @@ -8157,7 +8027,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + @@ -8173,7 +8043,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process multicellular anatomical structure - + @@ -8185,7 +8055,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + There is a cost to burying this in PATO. We lose that we could relax the cardinality assertion to subClassOf has_part some cell. I'm sure having this axiom inherited would come in handy. DOS @@ -8552,9 +8422,9 @@ MH: sexual subtypes should probably be logically defined based on sexual process FMA:86475 MESH:D006412 VHOG:0001485 - HSC blood forming stem cell hemopoietic stem cell + HSC colony forming unit hematopoietic @@ -8571,6 +8441,12 @@ MH: sexual subtypes should probably be logically defined based on sexual process PMID:19022770 http://en.wikipedia.org/wiki/Hematopoietic_stem_cell + + + + HSC + + @@ -8609,6 +8485,18 @@ MH: sexual subtypes should probably be logically defined based on sexual process GOC:add ISBN:0721601464 + + + + BFU-E + + + + + + CFU-E + + @@ -8700,6 +8588,12 @@ MH: sexual subtypes should probably be logically defined based on sexual process http://en.wikipedia.org/wiki/Monoblast http://www.copewithcytokines.de + + + + CFU-M + + @@ -8756,10 +8650,10 @@ MH: sexual subtypes should probably be logically defined based on sexual process A progenitor cell committed to myeloid lineage, including the megakaryocyte and erythroid lineages. BTO:0004730 - CMP common myeloid precursor CFU-GEMM CFU-S + CMP colony forming unit granulocyte, erythrocyte, macrophage, and megakaryocyte multipotential myeloid stem cell myeloid stem cell @@ -8784,21 +8678,24 @@ MH: sexual subtypes should probably be logically defined based on sexual process - - CMP + + CFU-GEMM ISBN:0878932437 + - CFU-GEMM + CFU-S ISBN:0878932437 + - CFU-S + CMP ISBN:0878932437 + @@ -8919,10 +8816,10 @@ MH: sexual subtypes should probably be logically defined based on sexual process A oligopotent progenitor cell committed to the lymphoid lineage. - CLP common lymphocyte precursor common lymphocyte progenitor common lymphoid precursor + CLP ELP committed lymphopoietic stem cell early lymphocyte progenitor @@ -8948,6 +8845,18 @@ MH: sexual subtypes should probably be logically defined based on sexual process PMID:10407577 PMID:16551251 + + + + CLP + + + + + + ELP + + @@ -9070,6 +8979,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process epithelial cell + https://www.swissbiopics.org/api/image/Epithelial_cells.svg @@ -9796,10 +9706,10 @@ MH: sexual subtypes should probably be logically defined based on sexual process BTO:0002625 BTO:0003298 FMA:70546 - BMSC bone marrow stromal cells colony-forming unit-fibroblast marrow stromal cells + BMSC CFU-F MSC mesenchymal precursor cell @@ -9838,11 +9748,24 @@ MH: sexual subtypes should probably be logically defined based on sexual process marrow stromal cells PMID:11378515 + + + + BMSC + + + + + + CFU-F + + MSC PMID:11378515 + @@ -9889,7 +9812,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process A cell capable of processing and presenting lipid and protein antigens to T cells in order to initiate an immune response. - APC + APC Note change of name; nearly all somatic cells can present antigens to T cells via MHC Class I complexes leading to effector responses, but professional antigen presenting cells constitutively express MHC Class II as well as costimulatory molecules, and thus can initiate immune responses via T cells. professional antigen presenting cell @@ -9901,6 +9824,12 @@ MH: sexual subtypes should probably be logically defined based on sexual process GOC:add ISBN:0781735149 + + + + APC + + @@ -9980,6 +9909,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process muscle fiber myocyte muscle cell + https://www.swissbiopics.org/api/image/Muscle_cells.svg @@ -10653,7 +10583,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process A cell derived from the specialized ectoderm flanking each side of the embryonic neural plate, which after the closure of the neural tube, forms masses of cells that migrate out from the dorsal aspect of the neural tube to spread throughout the body. - MESH:A16.254.600 + doi:10.1016/j.stem.2015.02.017 @@ -10970,6 +10900,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process These cells are also reportedly CD4-negative and CD200-positive. They are also capable of producing CD40L and IFN-gamma. neuron + https://www.swissbiopics.org/api/image/Neuron_cells.svg @@ -11247,7 +11178,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process An immature, nucleated erythrocyte occupying the stage of erythropoeisis that follows formation of erythroid progenitor cells. This cell is CD71-positive, has both a nucleus and a nucleolus, and lacks hematopoeitic lineage markers. ISBN:0721601464 - MESH:A11.118.290.350.200 PMID:1638021 @@ -11284,6 +11214,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process metazoan cell animal cell + https://www.swissbiopics.org/api/image/Animal_cells.svg @@ -11932,12 +11863,12 @@ MH: sexual subtypes should probably be logically defined based on sexual process A hematopoietic progenitor cell that is committed to the granulocyte and monocyte lineages. These cells are CD123-positive, and do not express Gata1 or Gata2 but do express C/EBPa, and Pu.1. CFU-C , Colony forming unit in culture - CFU-GM - GMP colony forming unit granulocyte macrophage granulocyte-macrophage progenitor granulocyte/monocyte precursor granulocyte/monocyte progenitor + CFU-GM + GMP Originally described in the dendritic cell ontology (DC_CL:0000042)(PMID:19243617). GMPs are reportedly CD16-positive, CD32-positive, CD34-positive, CD38-positive, CD45RA-positive, CD110-negative, CD117-positive, CD123-positive, and SCA1-negative. granulocyte monocyte progenitor cell @@ -11968,7 +11899,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - CFU-GM + colony forming unit granulocyte macrophage ISBN:0721601464 PMCID:PMC2213186 PMCID:PMC548021 @@ -11976,26 +11907,28 @@ MH: sexual subtypes should probably be logically defined based on sexual process - GMP + granulocyte-macrophage progenitor ISBN:0721601464 PMCID:PMC2213186 PMCID:PMC548021 - - colony forming unit granulocyte macrophage + + CFU-GM ISBN:0721601464 PMCID:PMC2213186 PMCID:PMC548021 + - - granulocyte-macrophage progenitor + + GMP ISBN:0721601464 PMCID:PMC2213186 PMCID:PMC548021 + @@ -13670,6 +13603,12 @@ MH: sexual subtypes should probably be logically defined based on sexual process GOC:tfm ISBN:0781735149 + + + + gd T cell + + @@ -16777,16 +16716,12 @@ MH: sexual subtypes should probably be logically defined based on sexual process + - - - - - - - - - + + + + A lymphocyte that has gotten larger after being stimulated by an antigen. 2022-08-17T14:20:01Z @@ -20324,32 +20259,32 @@ MH: sexual subtypes should probably be logically defined based on sexual process - - + + A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures. Wikipedia:Collagen cellular_component GO:0005581 collagen trimer - + - + - + PMID:12382326 - + PMID:12382326 @@ -22468,11 +22403,13 @@ MH: sexual subtypes should probably be logically defined based on sexual process Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538). + https://github.com/geneontology/go-ontology/issues/24680 biological_process accidental cell death necrosis GO:0008219 - This term should not be used for direct annotation. The only exception should be when experimental data (e.g., staining with trypan blue or propidium iodide) show that cell death has occurred, but fail to provide details on death modality (accidental versus programmed). When information is provided on the cell death mechanism, annotations should be made to the appropriate descendant of 'cell death' (such as, but not limited to, GO:0097300 'programmed necrotic cell death' or GO:0006915 'apoptotic process'). Also, if experimental data suggest that a gene product influences cell death indirectly, rather than being involved in the death process directly, consider annotating to a 'regulation' term. + + This term should not be used for direct annotation, it is currently kept in GO as a placeholder for describing cell death phenotypes in uPHENO. When information is provided on a programmed cell death mechanism, annotations should be made to the appropriate descendant of 'cell death' (such as, but not limited to, GO:0097300 'programmed necrotic cell death' or GO:0006915 'apoptotic process'). Unintentional cell death, i.e. cell death caused by injury, ageing, or cell phenotypes observed as a result of a pathological mutation in an essential gene should NOT be annotated using GO terms. cell death @@ -22486,6 +22423,34 @@ MH: sexual subtypes should probably be logically defined based on sexual process + + + + + The multiplication or reproduction of cells, resulting in the expansion of a cell population. + + biological_process + cell proliferation + GO:0008283 + + + + + + + This term was moved out from being a child of 'cellular process' because it is a cell population-level process, and cellular processes are restricted to those processes that involve individual cells. Also note that this term is intended to be used for the proliferation of cells within a multicellular organism, not for the expansion of a population of single-celled organisms. + cell population proliferation + + + + + The multiplication or reproduction of cells, resulting in the expansion of a cell population. + GOC:mah + GOC:mb + + + + @@ -22523,9 +22488,11 @@ MH: sexual subtypes should probably be logically defined based on sexual process + The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. - http://amigo.geneontology.org/amigo/term/GO:0070589 + https://github.com/geneontology/go-ontology/issues/15249 + https://github.com/geneontology/go-ontology/issues/25418 GO:0043284 biopolymer biosynthetic process macromolecule anabolism @@ -22863,9 +22830,10 @@ MH: sexual subtypes should probably be logically defined based on sexual process - - The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, translation and maturation for protein-coding genes. + + The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, as well as translation and maturation for protein-coding genes. https://github.com/geneontology/go-ontology/issues/22557 + https://github.com/geneontology/go-ontology/issues/25419 Wikipedia:Gene_expression biological_process GO:0010467 @@ -22875,7 +22843,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, translation and maturation for protein-coding genes. + The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, as well as translation and maturation for protein-coding genes. GOC:txnOH-2018 PMID:25934543 PMID:31580950 @@ -24050,6 +24018,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process + @@ -27403,6 +27372,29 @@ MH: sexual subtypes should probably be logically defined based on sexual process + + + + + + The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. + cellular anabolism + cellular biosynthesis + cellular formation + cellular synthesis + biological_process + GO:0044249 + cellular biosynthetic process + + + + + The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. + GOC:jl + + + + @@ -31682,6 +31674,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process + A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex but below that of an anatomical system. Or, a substance produced by a cellular organism with granularity above the level of a protein complex. kmv 2019-08-12T18:01:37Z @@ -38809,7 +38802,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + @@ -38845,14 +38838,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process gastrula stage - + - + BILS @@ -39073,7 +39066,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + @@ -39146,7 +39139,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process https://github.com/obophenotype/uberon/issues/661 http://upload.wikimedia.org/wikipedia/commons/0/06/Mouth_illustration-Otis_Archives.jpg - + @@ -39159,7 +39152,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + exceptions in some taxa @@ -39284,15 +39277,15 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + - - + + A fluid that is composed of blood plasma and erythrocytes. This class excludes blood analogues, such as the insect analog of blood. See UBERON:0000179 haemolymphatic fluid. @@ -39334,34 +39327,34 @@ MH: sexual subtypes should probably be logically defined based on sexual process blood - + - + - + - + CL:tm - + https://github.com/obophenotype/uberon/issues/1330 - + Bgee:AN @@ -39665,7 +39658,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + @@ -39707,14 +39700,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process organism substance - + - + this relationship may be too strong and may be weakened in future @@ -40944,7 +40937,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + Primary germ layer that is the outer of the embryo's three germ layers and gives rise to epidermis and neural tissue. Primary germ layer that is the outer of the embryonic germ layers and gives rise to epidermis and neural tissue.[AAO] The Bilateria are triploblastic (with true endoderm, mesoderm, and ectoderm) (...).[well established][VHOG] @@ -40982,14 +40975,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process ectoderm http://upload.wikimedia.org/wikipedia/commons/1/19/Gray32.png - + - + Bgee:AN @@ -41042,7 +41035,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + Primary germ layer that lies remote from the surface of the embryo and gives rise to internal tissues such as gut. The Bilateria are triploblastic (with true endoderm, mesoderm, and ectoderm) (...).[well established][VHOG] endodermal @@ -41079,14 +41072,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process http://upload.wikimedia.org/wikipedia/commons/c/c0/Endoderm2.png http://upload.wikimedia.org/wikipedia/commons/d/df/Gray10.png - + - + Bgee:AN @@ -41131,7 +41124,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + The middle germ layer of the embryo, between the endoderm and ectoderm. Primary germ layer that is the middle of the embryonic germ layers.[AAO] @@ -41176,7 +41169,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process mesoderm http://upload.wikimedia.org/wikipedia/commons/e/e8/Mesoderm.png - + @@ -41189,7 +41182,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + Bgee:AN @@ -41396,7 +41389,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + @@ -41470,14 +41463,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process Taxon notes:" the ascidian tube-like heart lacks chambers....The ascidian heart is formed after metamorphosis as a simple tube-like structure with a single-layered myoepithelium that is continuous with a single-layered pericar- dial wall. It lacks chambers and endocardium.... The innovation of the chambered heart was a key event in vertebrate evolution, because the chambered heart generates one-way blood flow with high pressure, a critical requirement for the efficient blood supply of large-body vertebrates... all extant vertebrates have hearts with two or more chambers (Moorman and Christoffels 2003)" DOI:10.1101/gad.1485706 heart - + - + MA @@ -42133,7 +42126,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + @@ -42186,14 +42179,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process http://upload.wikimedia.org/wikipedia/commons/b/b2/TE-Nervous_system_diagram.svg http://upload.wikimedia.org/wikipedia/commons/b/ba/Nervous_system_diagram.png - + - + Bgee:AN @@ -42281,7 +42274,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the neural tube derivatives: the brain and spinal cord. In invertebrates it includes central ganglia plus nerve cord. Part of the nervous system which includes the brain and spinal cord.[AAO] @@ -42328,7 +42321,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process central nervous system - + @@ -42342,7 +42335,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + Bgee:AN @@ -42836,7 +42829,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + Skeletal element that is composed of bone tissue. @@ -42886,14 +42879,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process bone element - + - + VSAO-modified @@ -43004,7 +42997,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + A tube extending from the mouth to the anus. @@ -43044,14 +43037,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process digestive tract - + - + NCBIBook:NBK10107 @@ -43328,8 +43321,8 @@ MH: sexual subtypes should probably be logically defined based on sexual process - - + + @@ -43342,7 +43335,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + @@ -43401,34 +43394,34 @@ MH: sexual subtypes should probably be logically defined based on sexual process blood vessel http://upload.wikimedia.org/wikipedia/commons/2/29/Circulatory_System_en.svg - + - + - + - + AEO - + EHDAA2 - + GO:0072360 @@ -44151,7 +44144,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + @@ -44185,14 +44178,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process musculoskeletal system - + - + check ctenophore @@ -44321,7 +44314,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + @@ -44362,14 +44355,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process coelemic cavity lumen - + - + definitional @@ -44477,9 +44470,9 @@ MH: sexual subtypes should probably be logically defined based on sexual process - - - + + + @@ -44534,15 +44527,15 @@ MH: sexual subtypes should probably be logically defined based on sexual process notochord http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png - + - + - + @@ -44561,19 +44554,19 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + http://tolweb.org/Chordata/2499 - + ZFA - + EHDAA2 @@ -44658,8 +44651,8 @@ MH: sexual subtypes should probably be logically defined based on sexual process - - + + Somites are spheres of epithelial cells that form sequentially along the anterior-posterior axis of the embryo through mesenchymal to epithelial transition of the presomitic mesoderm. currently classified as an epithelial vesicle, consistent with EHDAA2 and https://github.com/obophenotype/uberon/wiki/The-neural-crest. Consider making 'somitic mesoderm' a separate term and correlate with regionalization processes. Consider moving ZFA term to 'trunk somite' as it is part of the trunk @@ -44705,11 +44698,11 @@ MH: sexual subtypes should probably be logically defined based on sexual process somite http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png - + - + @@ -44722,13 +44715,13 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + GOTAX:0000352 - + ZFA @@ -44841,12 +44834,12 @@ MH: sexual subtypes should probably be logically defined based on sexual process - - - - - - + + + + + + A specialized region of ectoderm found between the neural ectoderm (neural plate) and non-neural ectoderm and composed of highly migratory pluripotent cells that delaminate in early embryonic development from the dorsal neural tube and give rise to an astounding variety of differentiated cell types[MP]. consider including subclasses for pre- and post- migratory (e.g. sheets/paths/streams). @@ -44886,66 +44879,66 @@ MH: sexual subtypes should probably be logically defined based on sexual process http://upload.wikimedia.org/wikipedia/commons/5/5f/Gray644.png https://upload.wikimedia.org/wikipedia/commons/8/8f/Neural_Crest.png - + - + - + - + - + - + - + XAO https://github.com/obophenotype/uberon/wiki/The-neural-crest - + Hall and others restrict NC to vertebrates but we opt for a less restrictive constraint to avoid inconsistencies when areas such as P1 area of pallium in hagfishes inherit cell lineage from telecephalon-contributing NC cells ISBN:0073040584 - + BTO - + PMID:11523831 - + pre migratory https://github.com/obophenotype/uberon/wiki/The-neural-crest - + PMID:11523831 @@ -45133,7 +45126,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + @@ -45191,14 +45184,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process bone marrow http://upload.wikimedia.org/wikipedia/commons/7/74/Gray72-en.svg - + - + FMA MA @@ -45469,14 +45462,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + - + Anatomical system that is involved in the production of hematopoietic cells. Anatomical system that consists of the blood and blood forming tissues.[AAO] @@ -45519,24 +45512,24 @@ MH: sexual subtypes should probably be logically defined based on sexual process hematopoietic system - + - + - + FMA - + definitional @@ -45907,7 +45900,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + Unsegmented field of paraxial mesoderm present posterior to the most recently formed somite pair, from which somites will form. Unsegmented field of paraxial mesoderm present posterior to the most recently formed somite pair, from which somites will form. Kimmel et al, 1995.[TAO] It is reasonable to assume that the proximate invertebrate ancestor of the vertebrates had an amphioxus-like tail bud in its larval stage. This archetypal tail bud would have (...) (3) lacked any component of mesenchyme cells, (4) budded off new mesodermal segments directly, without any intervening zone of presomitic mesoderm (...). Then, early in vertebrate evolution, epithelium-to-mesenchyme interconversions (and the gene networks for effecting them) became prominent features of development. (...) In any case, conspicuous mesenchymal components tended to be added to the vertebrate tail bud itself. In addition, a mesenchymatous presomitic mesoderm (not a part of the tail bud proper) came to intervene between the tail bud and the forming somites.[well established][VHOG] @@ -45932,14 +45925,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process presomitic mesoderm - + - + Bgee:AN @@ -46169,9 +46162,9 @@ MH: sexual subtypes should probably be logically defined based on sexual process - - - + + + A region of embryonic ectodermal cells that lie directly above the notochord. During neurulation, they change shape and produce an infolding of the neural plate (the neural fold) that then seals to form the neural tube[XAO]. The earliest recognizable dorsal ectodermal primordium of the central nervous system present near the end of gastrulation before infolding to form the neural keel; consists of a thickened pseudostratified epithelium[ZFA]. The earliest recognizable dorsal ectodermal primordium of the central nervous system present near the end of gastrulation before infolding to form the neural keel; consists of a thickened pseudostratified epithelium. Kimmel et al, 1995.[TAO] (...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...).[well established][VHOG] @@ -46203,34 +46196,34 @@ MH: sexual subtypes should probably be logically defined based on sexual process neural plate https://upload.wikimedia.org/wikipedia/commons/8/8f/Neural_Crest.png - + - + - + - + GOTAX:0000352 - + Wikipedia - + Bgee:AN @@ -46295,7 +46288,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + The paraxial mesoderm is the mesoderm located bilaterally adjacent to the notochord and neural tube[GO]. Mesoderm lateral to the neural tube and notochord that is divided into cranial and post-cranial portions. The trunk portions further segment into somites.[AAO] Presently, Cephalochordata, Urochordata, and Vertebrata are placed as subphyla of the phylum Chordata, in which the overall organization of embryonic tissues (dorsal hollow nerve cord, ventral digestive tract, axial notochord, and bilateral paraxial mesoderm) is largely conserved. In contrast, the echinoderms and hemichordates are sister groups of the chordates and they lack the notochord and paraxial mesoderm. Thus, the basic mesodermal organization of vertebrates must have appeared first in the common ancestor of the chordates.[well established][VHOG] @@ -46324,7 +46317,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process paraxial mesoderm http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png - + @@ -46337,7 +46330,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + Bgee:AN @@ -46409,7 +46402,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + @@ -46453,7 +46446,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process lateral plate mesoderm http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png - + @@ -46466,7 +46459,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + EHDAA2 VHOG @@ -46550,15 +46543,15 @@ MH: sexual subtypes should probably be logically defined based on sexual process - - + + - + Bilateral groups of cells consisting of three rows: one row of endocardial precursors medially and two rows of myocardical precursors laterally. The two populations fuse at the midline to form the heart rudiment or cone. should probably be merged with heart rudiment. Bilateral groups of cells consisting of three rows: one row of endocardial precursors medially and two rows of myocardical precursors laterally. The two populations fuse at the midline between 21 and 26 somites to form the heart rudiment or cone. Stainier 2001.[TAO] @@ -46578,15 +46571,15 @@ MH: sexual subtypes should probably be logically defined based on sexual process heart primordium - + - + - + @@ -46599,19 +46592,19 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + ZFA - + ZFA - + XAO @@ -46666,8 +46659,8 @@ MH: sexual subtypes should probably be logically defined based on sexual process - - + + Ventral somitic compartment that is a precursor of the axial skeleton[XAO]. Sclerotomes eventually differentiate into the vertebrae and most of the skull. The caudal (posterior) half of one sclerotome fuses with the rostral (anterior) half of the adjacent one to form each vertebra. From their initial location within the somite, the sclerotome cells migrate medially towards the notochord. These cells meet the sclerotome cells from the other side to form the vertebral body. From this vertebral body, sclerotome cells move dorsally and surround the developing spinal cord, forming the vertebral arch[WP]. Skeletogenic portion of somites.[AAO] The vertebrate sclerotome has no equivalent in amphioxus and is a novelty linked with the evolution of the axial skeleton.[well established][VHOG] @@ -46694,11 +46687,11 @@ MH: sexual subtypes should probably be logically defined based on sexual process sclerotome http://upload.wikimedia.org/wikipedia/commons/9/96/Gray65.png - + - + @@ -46717,13 +46710,13 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + VHOG:0000680 - + ZFA @@ -46989,7 +46982,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + The part of the coelom in the embryo between the somatopleuric and splanchnopleuric mesoderm; the principal body cavities of the trunk (thoracic, abdominal, and pelvic) arise from this embryonic part of the coelom. consider merging with coelom. TODO - add spatial relationships to halves of LPM. Note the OG places XAO and ZFA coelem terms here. editor note: TODO check ZFA, which appears to be a structure present in adults (...) I regard it unlikely that coeloms of all bilaterian animals are comparable and evolved very early. Considering all these questions, few convincing characters concerning the evolution of body cavities remain to be named. (...) A segmental coelom appears to have evolved at least two times, in Annelida and in Myomerata (Acrania and Craniota).[well established][VHOG] @@ -47005,14 +46998,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process intraembryonic coelom - + - + Wikipedia @@ -47331,8 +47324,8 @@ MH: sexual subtypes should probably be logically defined based on sexual process - - + + A specific region of the lateral mesoderm that will form the primary beating heart tube. In mammals the primary heart field gives rise to the left ventricle. this term denotes the primary heart field; GO:0003128 denotes the superclass of primary and secondary: specific region of the lateral mesoderm into the area which will form the primary beating heart tube[GO:0003138] XAO:0004185 @@ -47345,24 +47338,24 @@ MH: sexual subtypes should probably be logically defined based on sexual process UBERON:0004140 primary heart field - + - + - + GO:0003128 - + https://orcid.org/0000-0003-3308-6245 @@ -47421,7 +47414,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + An epithelial tube that will give rise to the mature heart. the paired, longitudinal, endothelial-lined channels formed from the cardiogenic mesoderm in embryonic development; angiogenic cell clusters (aka angioblastic cords) located in a horse-shoe shape configuration in the cardiogenic plate coalesce to form the right and left endocardial heart tubes which then fuse in cephalo-caudal direction to form a single primitive heart tube. AAO:0010411 @@ -47441,14 +47434,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process heart tube - + - + ZFA-modified @@ -48063,7 +48056,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + A specialized form of connective tissue in which the extracellular matrix is firm, providing the tissue with resilience, and/or mineralized and that functions in mechanical and structural support.[VSAO]. A specialized form of connective tissue in which the extracellular matrix is firm, providing the tissue with resilience, and/or mineralized and that functions in mechanical and structural support.[VSAO] EMAPA:37744 @@ -48077,7 +48070,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process Four classes of mineralized tissues are found in vertebrates: bone, cartilage, dentine, and enamel. We think of cartilage and bone as skeletal tissues and of enamel and dentine as dental tissues, but enamel and dentine arose evolutionarily together with bone as skeletal tissues in the dermal skeleton (exoskeleton) of early vertebrates. Scales and teeth of sharks are examples of dermal skeletal elements that are still composed of the three ancient components-enamel, dentine, and bone. Cartilage, on the other hand, provided the basis for the second vertebrate skeletal system, the endoskeleton (Smith and Hall, 1990; Hall, 1998a,b). some invertebrate skeletal tissues have surprisingly bone-like features. Examples include chondrocytes interconnected by cell processes in cephalopod cartilages (Cole and Hall, 2004a,b), and the calcium phosphate layer in the shells of brachiopods (Rodland et al., 2003). However, neither bone nor mineralized cartilage have been found in invertebrates. Editors notes: TODO - develops_from skeletal tissue - + @@ -48090,7 +48083,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + 2012-08-14 VSAO:0000015 VSAO @@ -48129,7 +48122,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + Organ consisting of skeletal tissue. Encompasses whole bones, fused bones, cartilaginious elements, teeth, dermal denticles. Organ entity that is typically involved in mechanical support and may have different skeletal tissue compositions at different stages.[VSAO] Organ entity that may have different tissue compositions at different stages and is typically involved in mechanical support.[TAO] @@ -48145,14 +48138,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process skeletal element - + - + VSAO @@ -48197,7 +48190,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + @@ -48236,14 +48229,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process UBERON:0004770 articular system - + - + FMA @@ -49001,7 +48994,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + Mesenchyme that is part of a developing trunk. EFO:0003485 EHDAA2:0002092 @@ -49017,14 +49010,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process trunk mesenchyme - + - + EHDAA2 @@ -49135,7 +49128,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + Multi-tissue structure that arises from the heart rudiment and will become the heart tube. EHDAA2:0001512 EHDAA:424 @@ -49153,14 +49146,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process primitive heart tube - + - + ZFA @@ -49328,7 +49321,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + A delimited region of dense mesenchyme within looser mesenchyme. AEO:0000148 EHDAA2_RETIRED:0003148 @@ -49338,7 +49331,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process UBERON:0005856 developing mesenchymal condensation - + @@ -49357,7 +49350,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + AEO-modified-relation @@ -49462,7 +49455,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + The notochordal plate is the dorsal part of the notochordal process when the ventral portion breaks down. It is continuous laterally with the endoderm that composes the roof of the primitive foregut and is in contact dorsally with the neural tube. The folding off of the notochordal plate gives rise to the notochord. TODO - check ordering; awaiting confirmation from JB The notochordal plate is the dorsal part of the notochordal process when the ventral portion breaks down. It is continuous laterally with the endoderm that composes the roof of the primitive foregut and is in contact dorsally with the neural tube. The folding off of the notochordal plate gives rise to the notochord. [Carson_JL, Dehart_DB, Developmental_Dynamics_(1994)_201:_260-278, Gesteland_K_and_Schoenwolf_GC, Inagaki_T, Morphogenesis_of_the_murine_node_and_notochordal_plate, The_prechordal_plate, Vrablic_T, see_Mueller_F_and_O'Rahilly_R, the_rostral_end_of_the_notochord_and_nearby_median_features_in_staged_human_embryos._Cells_Tissues_Organs_(2003)_173:_1-20_and_Sulik_K][VHOG] @@ -49477,7 +49470,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process notochordal plate - + @@ -49490,7 +49483,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + EHDAA2 @@ -49527,7 +49520,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + A midline cellular cord formed from the migration of mesenchymal cells from the primitive knot. EHDAA2:0001279 EHDAA:224 @@ -49544,14 +49537,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process The notochordal process grows cranially until it reaches the prechordal plate, the future site of the mouth. In this area the ectoderm is attached directly to the endoderm without intervening mesoderm. This area is known as the oropharyngeal membrane, and it will break down to become the mouth. At the other end of the primitive streak the ectoderm is also fused directly to the endoderm; this is known as the cloacal membrane (proctodeum), or primordial anus. notochordal process - + - + EHDAA2 @@ -50294,7 +50287,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + A hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood or analogs[GO,modified]. note we reserve the subclass 'heart' from the vertebrate multi-chambered heart. 'The first heart-like organ is believed to have appeared 500my ago in an ancestral bilaterian'. Amniotes: four-chambered heart. Amphibians: two atria, one ventricle, pulmonary; fish: single atrium and ventricle; amphioxus: tubular, non-striated, closed, unidirectional; ascidians: tubular, striated, open, bidirectional; arthropods: tubular, open; C elegans: contractile pharynx; Cnideria: striated muscle cells associated with gastrodermis SPD:0000130 @@ -50309,14 +50302,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process Gene notes: Bmp, Nkx, Gata primary circulatory organ - + - + GO uses blood circulation generically to include the haemolymphatic fluid of arthropods @@ -50406,7 +50399,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + @@ -50423,14 +50416,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process presumptive segmental plate - + - + https://github.com/obophenotype/uberon/wiki/The-neural-crest EDHAA2 @@ -50529,7 +50522,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + @@ -50555,7 +50548,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process presumptive paraxial mesoderm - + @@ -50571,7 +50564,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + https://github.com/obophenotype/uberon/issues/1277 @@ -50647,7 +50640,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + Mesenchyme with little extracellular matrix. AEO:0000146 EHDAA2:0003146 @@ -50655,7 +50648,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process UBERON:0007524 dense mesenchyme tissue - + @@ -50668,7 +50661,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + AEO @@ -50765,7 +50758,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + Anatomical system that consists of all blood and lymph vessels. consider merging with vasculature The cardiovascular and lymphatic systems, collectively[ncithesaurus:Vascular_System]. @@ -50782,14 +50775,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process vascular system - + - + MA @@ -50922,7 +50915,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + @@ -50939,14 +50932,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process UBERON:0009142 entire embryonic mesenchyme - + - + EHDAA2 @@ -51002,7 +50995,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + EHDAA2:0002094 trunk and cervical paraxial mesenchyme uberon @@ -51010,14 +51003,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process UBERON:0009618 trunk paraxial mesoderm - + - + EHDAA2 @@ -51039,7 +51032,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + EFO:0003704 TAO:0005041 ZFA:0005041 @@ -51049,14 +51042,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process anterior lateral plate mesoderm - + - + ZFA @@ -51190,7 +51183,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + @@ -51210,14 +51203,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process UBERON:0010210 blood clot - + - + BTO @@ -51339,8 +51332,8 @@ MH: sexual subtypes should probably be logically defined based on sexual process - - + + Anatomical cluster consisting of the skeletal elements (i.e. bone elements, cartilage elements, cartilage condensations) that are part of an individual subdivision of the organism. Excludes joints. Anatomical cluster consisting of the skeletal elements that are part of the skeleton.[VSAO] FMA:23879 @@ -51353,11 +51346,11 @@ MH: sexual subtypes should probably be logically defined based on sexual process subdivision of skeleton - + - + @@ -51370,13 +51363,13 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + UBERONREF:0000003 - + VSAO @@ -51453,7 +51446,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + Subdivision of the skeletal system which consists of the postcranial axial skeleton plus associated joints. axial skeletal system FMA:302077 @@ -51463,7 +51456,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process postcranial axial skeletal system http://purl.obolibrary.org/obo/uberon/docs/The-axial-skeleton - + @@ -51476,7 +51469,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + cjm @@ -51741,7 +51734,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + @@ -51763,7 +51756,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process UBERON:0012429 hematopoietic tissue - + @@ -51776,7 +51769,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + defitional @@ -52346,7 +52339,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + @@ -52369,7 +52362,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process UBERON:0016887 entire extraembryonic component - + @@ -52382,7 +52375,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + AEO @@ -52607,196 +52600,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process - - - - - - - - - example to be eventually removed - example to be eventually removed - - - - - - - - failed exploratory term - The term was used in an attempt to structure part of the ontology but in retrospect failed to do a good job - Person:Alan Ruttenberg - failed exploratory term - - - - - - - - metadata complete - Class has all its metadata, but is either not guaranteed to be in its final location in the asserted IS_A hierarchy or refers to another class that is not complete. - metadata complete - - - - - - - - organizational term - Term created to ease viewing/sort terms for development purpose, and will not be included in a release - organizational term - - - - - - - - ready for release - Class has undergone final review, is ready for use, and will be included in the next release. Any class lacking "ready_for_release" should be considered likely to change place in hierarchy, have its definition refined, or be obsoleted in the next release. Those classes deemed "ready_for_release" will also derived from a chain of ancestor classes that are also "ready_for_release." - ready for release - - - - - - - - metadata incomplete - Class is being worked on; however, the metadata (including definition) are not complete or sufficiently clear to the branch editors. - metadata incomplete - - - - - - - - uncurated - Nothing done yet beyond assigning a unique class ID and proposing a preferred term. - uncurated - - - - - - - - pending final vetting - All definitions, placement in the asserted IS_A hierarchy and required minimal metadata are complete. The class is awaiting a final review by someone other than the term editor. - pending final vetting - - - - - - - - placeholder removed - placeholder removed - - - - - - - - terms merged - An editor note should explain what were the merged terms and the reason for the merge. - terms merged - - - - - - - - term imported - This is to be used when the original term has been replaced by a term imported from an other ontology. An editor note should indicate what is the URI of the new term to use. - term imported - - - - - - - - term split - This is to be used when a term has been split in two or more new terms. An editor note should indicate the reason for the split and indicate the URIs of the new terms created. - term split - - - - - - - - universal - Hard to give a definition for. Intuitively a "natural kind" rather than a collection of any old things, which a class is able to be, formally. At the meta level, universals are defined as positives, are disjoint with their siblings, have single asserted parents. - Alan Ruttenberg - A Formal Theory of Substances, Qualities, and Universals, http://ontology.buffalo.edu/bfo/SQU.pdf - universal - - - - - - - - defined class - A defined class is a class that is defined by a set of logically necessary and sufficient conditions but is not a universal - "definitions", in some readings, always are given by necessary and sufficient conditions. So one must be careful (and this is difficult sometimes) to distinguish between defined classes and universal. - Alan Ruttenberg - defined class - - - - - - - - named class expression - A named class expression is a logical expression that is given a name. The name can be used in place of the expression. - named class expressions are used in order to have more concise logical definition but their extensions may not be interesting classes on their own. In languages such as OWL, with no provisions for macros, these show up as actuall classes. Tools may with to not show them as such, and to replace uses of the macros with their expansions - Alan Ruttenberg - named class expression - - - - - - - - to be replaced with external ontology term - Terms with this status should eventually replaced with a term from another ontology. - Alan Ruttenberg - group:OBI - to be replaced with external ontology term - - - - - - - - requires discussion - A term that is metadata complete, has been reviewed, and problems have been identified that require discussion before release. Such a term requires editor note(s) to identify the outstanding issues. - Alan Ruttenberg - group:OBI - requires discussion - - - - - + + symbol + @@ -75,34 +77,7 @@ - definition - - The official definition, explaining the meaning of a class or property. Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions. - 2012-04-05: -Barry Smith - -The official OBI definition, explaining the meaning of a class or property: 'Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions' is terrible. - -Can you fix to something like: - -A statement of necessary and sufficient conditions explaining the meaning of an expression referring to a class or property. - -Alan Ruttenberg - -Your proposed definition is a reasonable candidate, except that it is very common that necessary and sufficient conditions are not given. Mostly they are necessary, occasionally they are necessary and sufficient or just sufficient. Often they use terms that are not themselves defined and so they effectively can't be evaluated by those criteria. - -On the specifics of the proposed definition: - -We don't have definitions of 'meaning' or 'expression' or 'property'. For 'reference' in the intended sense I think we use the term 'denotation'. For 'expression', I think we you mean symbol, or identifier. For 'meaning' it differs for class and property. For class we want documentation that let's the intended reader determine whether an entity is instance of the class, or not. For property we want documentation that let's the intended reader determine, given a pair of potential relata, whether the assertion that the relation holds is true. The 'intended reader' part suggests that we also specify who, we expect, would be able to understand the definition, and also generalizes over human and computer reader to include textual and logical definition. - -Personally, I am more comfortable weakening definition to documentation, with instructions as to what is desirable. - -We also have the outstanding issue of how to aim different definitions to different audiences. A clinical audience reading chebi wants a different sort of definition documentation/definition from a chemistry trained audience, and similarly there is a need for a definition that is adequate for an ontologist to work with. - PERSON:Daniel Schober - GROUP:OBI:<http://purl.obolibrary.org/obo/obi> - definition - definition @@ -110,19 +85,12 @@ We also have the outstanding issue of how to aim different definitions to differ - editor note - - An administrative note intended for its editor. It may not be included in the publication version of the ontology, so it should contain nothing necessary for end users to understand the ontology. - PERSON:Daniel Schober - GROUP:OBI:<http://purl.obofoundry.org/obo/obi> IAO:0000116 uberon editor_note true editor_note - editor note - editor note @@ -147,13 +115,7 @@ We also have the outstanding issue of how to aim different definitions to differ - - has obsolescence reason - Relates an annotation property to an obsolescence reason. The values of obsolescence reasons come from a list of predefined terms, instances of the class obsolescence reason specification. - PERSON:Alan Ruttenberg - PERSON:Melanie Courtot - has obsolescence reason - + @@ -166,12 +128,6 @@ We also have the outstanding issue of how to aim different definitions to differ - term tracker item - the URI for an OBI Terms ticket at sourceforge, such as https://sourceforge.net/p/obi/obi-terms/772/ - - An IRI or similar locator for a request or discussion of an ontology term. - Person: Jie Zheng, Chris Stoeckert, Alan Ruttenberg - Person: Jie Zheng, Chris Stoeckert, Alan Ruttenberg IAO:0000233 external uberon @@ -179,9 +135,7 @@ We also have the outstanding issue of how to aim different definitions to differ true true term_tracker_item - The 'tracker item' can associate a tracker with a specific ontology term. term tracker item - term tracker item @@ -189,15 +143,7 @@ We also have the outstanding issue of how to aim different definitions to differ - expand expression to - ObjectProperty: RO_0002104 -Label: has plasma membrane part -Annotations: IAO_0000424 "http://purl.obolibrary.org/obo/BFO_0000051 some (http://purl.org/obo/owl/GO#GO_0005886 and http://purl.obolibrary.org/obo/BFO_0000051 some ?Y)" - - A macro expansion tag applied to an object property (or possibly a data property) which can be used by a macro-expansion engine to generate more complex expressions from simpler ones - Chris Mungall expand expression to - expand expression to @@ -229,16 +175,14 @@ Annotations: IAO_0000424 "http://purl.obolibrary.org/obo/BFO_0000051 some ( - has ontology root term - Ontology annotation property. Relates an ontology to a term that is a designated root term of the ontology. Display tools like OLS can use terms annotated with this property as the starting point for rendering the ontology class hierarchy. There can be more than one root. - Nicolas Matentzoglu IAO:0000700 + external uberon has_ontology_root_term + true true has_ontology_root_term has ontology root term - has ontology root term preferred_root @@ -253,14 +197,7 @@ Annotations: IAO_0000424 "http://purl.obolibrary.org/obo/BFO_0000051 some ( - term replaced by - - Use on obsolete terms, relating the term to another term that can be used as a substitute - Person:Alan Ruttenberg - Person:Alan Ruttenberg - Add as annotation triples in the granting ontology term replaced by - term replaced by @@ -1433,12 +1370,6 @@ WHERE { - - - - - - @@ -1503,6 +1434,12 @@ WHERE { + + + + + + @@ -2070,7 +2007,7 @@ A continuant cannot have an occurrent as part: use 'participates in'. An example is: translation preceded_by transcription; aging preceded_by development (not however death preceded_by aging). Where derives_from links classes of continuants, preceded_by links classes of processes. Clearly, however, these two relations are not independent of each other. Thus if cells of type C1 derive_from cells of type C, then any cell division involving an instance of C1 in a given lineage is preceded_by cellular processes involving an instance of C. The assertion P preceded_by P1 tells us something about Ps in general: that is, it tells us something about what happened earlier, given what we know about what happened later. Thus it does not provide information pointing in the opposite direction, concerning instances of P1 in general; that is, that each is such as to be succeeded by some instance of P. Note that an assertion to the effect that P preceded_by P1 is rather weak; it tells us little about the relations between the underlying instances in virtue of which the preceded_by relation obtains. Typically we will be interested in stronger relations, for example in the relation immediately_preceded_by, or in relations which combine preceded_by with a condition to the effect that the corresponding instances of P and P1 share participants, or that their participants are connected by relations of derivation, or (as a first step along the road to a treatment of causality) that the one process in some way affects (for example, initiates or regulates) the other. is preceded by preceded_by - http://www.obofoundry.org/ro/#OBO_REL:preceded_by + http://www.obofoundry.org/ro/#OBO_REL:preceded_by BFO:0000062 external uberon @@ -2502,24 +2439,6 @@ A continuant cannot have an occurrent as part: use 'participates in'. - - - - This document is about information artifacts and their representations - - A (currently) primitive relation that relates an information artifact to an entity. - 7/6/2009 Alan Ruttenberg. Following discussion with Jonathan Rees, and introduction of "mentions" relation. Weaken the is_about relationship to be primitive. - -We will try to build it back up by elaborating the various subproperties that are more precisely defined. - -Some currently missing phenomena that should be considered "about" are predications - "The only person who knows the answer is sitting beside me" , Allegory, Satire, and other literary forms that can be topical without explicitly mentioning the topic. - person:Alan Ruttenberg - Smith, Ceusters, Ruttenberg, 2000 years of philosophy - is about - - - - @@ -2600,7 +2519,7 @@ Some currently missing phenomena that should be considered "about" are a relation between a process and a continuant, in which the continuant is somehow involved in the process Has_participant is a primitive instance-level relation between a process, a continuant, and a time at which the continuant participates in some way in the process. The relation obtains, for example, when this particular process of oxygen exchange across this particular alveolar membrane has_participant this particular sample of hemoglobin at this particular time. has_participant - http://www.obofoundry.org/ro/#OBO_REL:has_participant + http://www.obofoundry.org/ro/#OBO_REL:has_participant RO:0000057 external has_participant @@ -2783,43 +2702,18 @@ Some currently missing phenomena that should be considered "about" are - - - - - - - - - - - contained in - Containment is location not involving parthood, and arises only where some immaterial continuant is involved. - Containment obtains in each case between material and immaterial continuants, for instance: lung contained_in thoracic cavity; bladder contained_in pelvic cavity. Hence containment is not a transitive relation. If c part_of c1 at t then we have also, by our definition and by the axioms of mereology applied to spatial regions, c located_in c1 at t. Thus, many examples of instance-level location relations for continuants are in fact cases of instance-level parthood. For material continuants location and parthood coincide. Containment is location not involving parthood, and arises only where some immaterial continuant is involved. To understand this relation, we first define overlap for continuants as follows: c1 overlap c2 at t =def for some c, c part_of c1 at t and c part_of c2 at t. The containment relation on the instance level can then be defined (see definition): - Intended meaning: -domain: material entity -range: spatial region or site (immaterial continuant) - - contained_in - - - contained in - - - - contains - RO:0001019 uberon contains - contains contains - contains + obsolete contains + + true @@ -2842,7 +2736,7 @@ range: spatial region or site (immaterial continuant) Most location relations will only hold at certain times, but this is difficult to specify in OWL. See http://purl.obolibrary.org/obo/ro/docs/temporal-semantics/ located_in - http://www.obofoundry.org/ro/#OBO_REL:located_in + http://www.obofoundry.org/ro/#OBO_REL:located_in RO:0001025 uberon located_in @@ -6939,16 +6833,6 @@ For example, A and B may be gene products and binding of B by A positively regul - - - - A relationship that holds between two entities, where the entities exhibit a statistical dependence relationship. The entities may be statistical variables, or they may be other kinds of entities such as diseases, chemical entities or processes. - Groups both positive and negative correlation - correlated with - - - - @@ -7478,27 +7362,13 @@ For example, A and B may be gene products and binding of B by A positively regul A diagnostic testing device utilizes a specimen means that the diagnostic testing device is capable of an assay, and this assay a specimen as its input. See github ticket https://github.com/oborel/obo-relations/issues/497 - 2021-11-08T12:00:00Z + 2021-11-08T12:00:00Z utilizes device utilizes material - - - - - - - A relation between entities in which one increases or decreases as the other does the same. - directly correlated with - - positively correlated with - - - - @@ -8173,7 +8043,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + @@ -8189,7 +8059,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process multicellular anatomical structure - + @@ -8201,7 +8071,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + There is a cost to burying this in PATO. We lose that we could relax the cardinality assertion to subClassOf has_part some cell. I'm sure having this axiom inherited would come in handy. DOS @@ -8711,9 +8581,9 @@ MH: sexual subtypes should probably be logically defined based on sexual process FMA:86475 MESH:D006412 VHOG:0001485 - HSC blood forming stem cell hemopoietic stem cell + HSC colony forming unit hematopoietic @@ -8730,6 +8600,12 @@ MH: sexual subtypes should probably be logically defined based on sexual process PMID:19022770 http://en.wikipedia.org/wiki/Hematopoietic_stem_cell + + + + HSC + + @@ -8768,6 +8644,18 @@ MH: sexual subtypes should probably be logically defined based on sexual process GOC:add ISBN:0721601464 + + + + BFU-E + + + + + + CFU-E + + @@ -8822,10 +8710,10 @@ MH: sexual subtypes should probably be logically defined based on sexual process A progenitor cell committed to myeloid lineage, including the megakaryocyte and erythroid lineages. BTO:0004730 - CMP common myeloid precursor CFU-GEMM CFU-S + CMP colony forming unit granulocyte, erythrocyte, macrophage, and megakaryocyte multipotential myeloid stem cell myeloid stem cell @@ -8850,21 +8738,24 @@ MH: sexual subtypes should probably be logically defined based on sexual process - - CMP + + CFU-GEMM ISBN:0878932437 + - CFU-GEMM + CFU-S ISBN:0878932437 + - CFU-S + CMP ISBN:0878932437 + @@ -9077,6 +8968,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process epithelial cell + https://www.swissbiopics.org/api/image/Epithelial_cells.svg @@ -9535,7 +9427,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process An hexagonal, flattened, mitochondria-rich endothelial cell that forms a monolayer on the posterior surface of the cornea (the corneal endothelium). Corneal endothelial cells are derived from the neural crest and are responsible for keeping the cornea transparent by maintaining the tissue in a semi-dry state through the action of their ionic pumps and tight junction barrier. GOC:tfm - MESH:A09.371.060.067.31 PMID:21976958 PMID:23284695 PMID:34741068 @@ -9571,10 +9462,10 @@ MH: sexual subtypes should probably be logically defined based on sexual process BTO:0002625 BTO:0003298 FMA:70546 - BMSC bone marrow stromal cells colony-forming unit-fibroblast marrow stromal cells + BMSC CFU-F MSC mesenchymal precursor cell @@ -9613,11 +9504,24 @@ MH: sexual subtypes should probably be logically defined based on sexual process marrow stromal cells PMID:11378515 + + + + BMSC + + + + + + CFU-F + + MSC PMID:11378515 + @@ -9807,6 +9711,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process muscle fiber myocyte muscle cell + https://www.swissbiopics.org/api/image/Muscle_cells.svg @@ -9929,6 +9834,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process CALOHA:TS-0868 FMA:86740 photoreceptor cell + https://www.swissbiopics.org/api/image/Photoreceptor_cell.svg @@ -10330,7 +10236,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process A cell derived from the specialized ectoderm flanking each side of the embryonic neural plate, which after the closure of the neural tube, forms masses of cells that migrate out from the dorsal aspect of the neural tube to spread throughout the body. - MESH:A16.254.600 + doi:10.1016/j.stem.2015.02.017 @@ -10695,6 +10601,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process These cells are also reportedly CD4-negative and CD200-positive. They are also capable of producing CD40L and IFN-gamma. neuron + https://www.swissbiopics.org/api/image/Neuron_cells.svg @@ -10925,7 +10832,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process An immature, nucleated erythrocyte occupying the stage of erythropoeisis that follows formation of erythroid progenitor cells. This cell is CD71-positive, has both a nucleus and a nucleolus, and lacks hematopoeitic lineage markers. ISBN:0721601464 - MESH:A11.118.290.350.200 PMID:1638021 @@ -10962,6 +10868,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process metazoan cell animal cell + https://www.swissbiopics.org/api/image/Animal_cells.svg @@ -15322,32 +15229,32 @@ plexiform layer. - - + + A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures. Wikipedia:Collagen cellular_component GO:0005581 collagen trimer - + - + - + PMID:12382326 - + PMID:12382326 @@ -17005,11 +16912,13 @@ plexiform layer. Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538). + https://github.com/geneontology/go-ontology/issues/24680 biological_process accidental cell death necrosis GO:0008219 - This term should not be used for direct annotation. The only exception should be when experimental data (e.g., staining with trypan blue or propidium iodide) show that cell death has occurred, but fail to provide details on death modality (accidental versus programmed). When information is provided on the cell death mechanism, annotations should be made to the appropriate descendant of 'cell death' (such as, but not limited to, GO:0097300 'programmed necrotic cell death' or GO:0006915 'apoptotic process'). Also, if experimental data suggest that a gene product influences cell death indirectly, rather than being involved in the death process directly, consider annotating to a 'regulation' term. + + This term should not be used for direct annotation, it is currently kept in GO as a placeholder for describing cell death phenotypes in uPHENO. When information is provided on a programmed cell death mechanism, annotations should be made to the appropriate descendant of 'cell death' (such as, but not limited to, GO:0097300 'programmed necrotic cell death' or GO:0006915 'apoptotic process'). Unintentional cell death, i.e. cell death caused by injury, ageing, or cell phenotypes observed as a result of a pathological mutation in an essential gene should NOT be annotated using GO terms. cell death @@ -17023,6 +16932,34 @@ plexiform layer. + + + + + The multiplication or reproduction of cells, resulting in the expansion of a cell population. + + biological_process + cell proliferation + GO:0008283 + + + + + + + This term was moved out from being a child of 'cellular process' because it is a cell population-level process, and cellular processes are restricted to those processes that involve individual cells. Also note that this term is intended to be used for the proliferation of cells within a multicellular organism, not for the expansion of a population of single-celled organisms. + cell population proliferation + + + + + The multiplication or reproduction of cells, resulting in the expansion of a cell population. + GOC:mah + GOC:mb + + + + @@ -17060,9 +16997,11 @@ plexiform layer. + The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. - http://amigo.geneontology.org/amigo/term/GO:0070589 + https://github.com/geneontology/go-ontology/issues/15249 + https://github.com/geneontology/go-ontology/issues/25418 GO:0043284 biopolymer biosynthetic process macromolecule anabolism @@ -17482,9 +17421,10 @@ plexiform layer. - - The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, translation and maturation for protein-coding genes. + + The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, as well as translation and maturation for protein-coding genes. https://github.com/geneontology/go-ontology/issues/22557 + https://github.com/geneontology/go-ontology/issues/25419 Wikipedia:Gene_expression biological_process GO:0010467 @@ -17494,7 +17434,7 @@ plexiform layer. - The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, translation and maturation for protein-coding genes. + The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, as well as translation and maturation for protein-coding genes. GOC:txnOH-2018 PMID:25934543 PMID:31580950 @@ -18357,6 +18297,7 @@ plexiform layer. + @@ -20499,6 +20440,29 @@ plexiform layer. + + + + + + The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. + cellular anabolism + cellular biosynthesis + cellular formation + cellular synthesis + biological_process + GO:0044249 + cellular biosynthetic process + + + + + The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. + GOC:jl + + + + @@ -23359,8 +23323,8 @@ plexiform layer. + - @@ -23374,8 +23338,8 @@ plexiform layer. The part of synaptic transmission occurring in the post-synapse: a signal transduction pathway consisting of neurotransmitter receptor activation and its effects on postsynaptic membrane potential and the ionic composition of the postsynaptic cytosol. + postsynaptic process involved in chemical synaptic transmission biological_process - postsynaptic process involved in chemical synaptic transmission GO:0099565 chemical synaptic transmission, postsynaptic @@ -23388,7 +23352,7 @@ plexiform layer. - + postsynaptic process involved in chemical synaptic transmission @@ -23454,6 +23418,7 @@ plexiform layer. + A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex but below that of an anatomical system. Or, a substance produced by a cellular organism with granularity above the level of a protein complex. kmv 2019-08-12T18:01:37Z @@ -23904,94 +23869,6 @@ plexiform layer. - - - - - - - - - - - - - - - - - - - - - - Any cell surface receptor signaling pathway that is involved in cell-cell signaling. - dos - 2016-04-06T16:59:57Z - cell surface receptor linked signal transduction involved in cell-cell signaling - cell surface receptor linked signal transduction involved in cell-cell signalling - cell surface receptor linked signaling pathway involved in cell-cell signaling - cell surface receptor linked signaling pathway involved in cell-cell signalling - cell surface receptor linked signalling pathway involved in cell-cell signaling - cell surface receptor linked signalling pathway involved in cell-cell signalling - cell surface receptor signaling pathway involved in cell-cell signalling - biological_process - GO:1905114 - cell surface receptor signaling pathway involved in cell-cell signaling - - - - - Any cell surface receptor signaling pathway that is involved in cell-cell signaling. - GOC:TermGenie - GO_REF:0000060 - ISBN:0-7167-3051-0 - - - - - cell surface receptor linked signal transduction involved in cell-cell signaling - GOC:TermGenie - - - - - cell surface receptor linked signal transduction involved in cell-cell signalling - GOC:TermGenie - - - - - cell surface receptor linked signaling pathway involved in cell-cell signaling - GOC:TermGenie - - - - - cell surface receptor linked signaling pathway involved in cell-cell signalling - GOC:TermGenie - - - - - cell surface receptor linked signalling pathway involved in cell-cell signaling - GOC:TermGenie - - - - - cell surface receptor linked signalling pathway involved in cell-cell signalling - GOC:TermGenie - - - - - cell surface receptor signaling pathway involved in cell-cell signalling - GOC:TermGenie - - - - @@ -27406,7 +27283,7 @@ plexiform layer. - + @@ -27447,14 +27324,14 @@ plexiform layer. camera-type eye - + - + definitional @@ -28555,7 +28432,7 @@ plexiform layer. - + The surface (external) layer of ectoderm which begins to proliferate shortly after separation from the neuroectoderm. merge with non-neural. In vertebrates, the ectoderm has three parts: external ectoderm (also known as surface ectoderm), the neurectoderm (neural crest, and neural tube) @@ -28580,7 +28457,7 @@ plexiform layer. external ectoderm http://upload.wikimedia.org/wikipedia/commons/1/1d/Ectoderm.png - + @@ -28593,7 +28470,7 @@ plexiform layer. - + EHDAA2 @@ -28962,7 +28839,7 @@ plexiform layer. - + @@ -28998,14 +28875,14 @@ plexiform layer. gastrula stage - + - + BILS @@ -29271,7 +29148,7 @@ plexiform layer. - + @@ -29344,7 +29221,7 @@ plexiform layer. https://github.com/obophenotype/uberon/issues/661 http://upload.wikimedia.org/wikipedia/commons/0/06/Mouth_illustration-Otis_Archives.jpg - + @@ -29357,7 +29234,7 @@ plexiform layer. - + exceptions in some taxa @@ -29482,15 +29359,15 @@ plexiform layer. - + - - + + A fluid that is composed of blood plasma and erythrocytes. This class excludes blood analogues, such as the insect analog of blood. See UBERON:0000179 haemolymphatic fluid. @@ -29532,34 +29409,34 @@ plexiform layer. blood - + - + - + - + CL:tm - + https://github.com/obophenotype/uberon/issues/1330 - + Bgee:AN @@ -29863,7 +29740,7 @@ plexiform layer. - + @@ -29905,14 +29782,14 @@ plexiform layer. organism substance - + - + this relationship may be too strong and may be weakened in future @@ -31245,7 +31122,7 @@ plexiform layer. - + Primary germ layer that is the outer of the embryo's three germ layers and gives rise to epidermis and neural tissue. Primary germ layer that is the outer of the embryonic germ layers and gives rise to epidermis and neural tissue.[AAO] The Bilateria are triploblastic (with true endoderm, mesoderm, and ectoderm) (...).[well established][VHOG] @@ -31283,14 +31160,14 @@ plexiform layer. ectoderm http://upload.wikimedia.org/wikipedia/commons/1/19/Gray32.png - + - + Bgee:AN @@ -31343,7 +31220,7 @@ plexiform layer. - + Primary germ layer that lies remote from the surface of the embryo and gives rise to internal tissues such as gut. The Bilateria are triploblastic (with true endoderm, mesoderm, and ectoderm) (...).[well established][VHOG] endodermal @@ -31380,14 +31257,14 @@ plexiform layer. http://upload.wikimedia.org/wikipedia/commons/c/c0/Endoderm2.png http://upload.wikimedia.org/wikipedia/commons/d/df/Gray10.png - + - + Bgee:AN @@ -31432,7 +31309,7 @@ plexiform layer. - + The middle germ layer of the embryo, between the endoderm and ectoderm. Primary germ layer that is the middle of the embryonic germ layers.[AAO] @@ -31477,7 +31354,7 @@ plexiform layer. mesoderm http://upload.wikimedia.org/wikipedia/commons/e/e8/Mesoderm.png - + @@ -31490,7 +31367,7 @@ plexiform layer. - + Bgee:AN @@ -31712,7 +31589,7 @@ plexiform layer. - + @@ -31778,14 +31655,14 @@ plexiform layer. cranial nerve II - + - + EHDAA2 @@ -31929,7 +31806,7 @@ plexiform layer. - + @@ -32003,14 +31880,14 @@ plexiform layer. Taxon notes:" the ascidian tube-like heart lacks chambers....The ascidian heart is formed after metamorphosis as a simple tube-like structure with a single-layered myoepithelium that is continuous with a single-layered pericar- dial wall. It lacks chambers and endocardium.... The innovation of the chambered heart was a key event in vertebrate evolution, because the chambered heart generates one-way blood flow with high pressure, a critical requirement for the efficient blood supply of large-body vertebrates... all extant vertebrates have hearts with two or more chambers (Moorman and Christoffels 2003)" DOI:10.1101/gad.1485706 heart - + - + MA @@ -32088,7 +31965,7 @@ plexiform layer. - + @@ -32113,7 +31990,7 @@ plexiform layer. - + The brain is the center of the nervous system in all vertebrate, and most invertebrate, animals. Some primitive animals such as jellyfish and starfish have a decentralized nervous system without a brain, while sponges lack any nervous system at all. In vertebrates, the brain is located in the head, protected by the skull and close to the primary sensory apparatus of vision, hearing, balance, taste, and smell[WP]. requires review for applicability to invertebrate structures, e.g. synganglion @@ -32174,11 +32051,11 @@ plexiform layer. brain - + - + @@ -32191,13 +32068,13 @@ plexiform layer. - + FMA - + Bgee:AN @@ -32498,9 +32375,9 @@ plexiform layer. - - - + + + @@ -32525,7 +32402,7 @@ plexiform layer. - + @@ -32581,44 +32458,44 @@ plexiform layer. cornea http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg - + - + - + - + - + MA - + MA - + FMA-isa - + definitional @@ -32807,10 +32684,10 @@ plexiform layer. - - - - + + + + The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates. @@ -32861,44 +32738,44 @@ plexiform layer. retina http://upload.wikimedia.org/wikipedia/commons/e/ed/Human_eye_cross-sectional_view_grayscale.png - + - + - + - + - + FMA - + FMA - + FMA - + EHDAA2 @@ -32972,8 +32849,8 @@ plexiform layer. - - + + @@ -33009,24 +32886,24 @@ plexiform layer. eye - + - + - + PMID:21062451 - + PMID:21062451 @@ -33626,7 +33503,7 @@ plexiform layer. - + @@ -33679,14 +33556,14 @@ plexiform layer. http://upload.wikimedia.org/wikipedia/commons/b/b2/TE-Nervous_system_diagram.svg http://upload.wikimedia.org/wikipedia/commons/b/ba/Nervous_system_diagram.png - + - + Bgee:AN @@ -33774,7 +33651,7 @@ plexiform layer. - + The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the neural tube derivatives: the brain and spinal cord. In invertebrates it includes central ganglia plus nerve cord. Part of the nervous system which includes the brain and spinal cord.[AAO] @@ -33821,7 +33698,7 @@ plexiform layer. central nervous system - + @@ -33835,7 +33712,7 @@ plexiform layer. - + Bgee:AN @@ -34582,7 +34459,7 @@ plexiform layer. - + Simple squamous epithelium of mesodermal origin which lines serous membranes. Examples: mesothelium of pleura, mesothelium of peritoneum[FMA]. Wikipedia: The mesothelium is a membrane that forms the lining of several body cavities: the pleura (thoracal cavity), peritoneum (abdominal cavity including the mesentery) and pericardium (heart sac). Mesothelial tissue also surrounds the male internal reproductive organs (the tunica vaginalis testis) and covers the internal reproductive organs of women (the tunica serosa uteri). AEO:0000111 BTO:0002422 @@ -34607,14 +34484,14 @@ plexiform layer. mesothelium http://upload.wikimedia.org/wikipedia/commons/2/25/Mesothelium_peritoneal_wash_high_mag.jpg - + - + FMA @@ -34987,7 +34864,7 @@ plexiform layer. - + A tube extending from the mouth to the anus. @@ -35027,14 +34904,14 @@ plexiform layer. digestive tract - + - + NCBIBook:NBK10107 @@ -35114,7 +34991,7 @@ plexiform layer. - + The ciliary muscle is a ring of smooth muscle in the middle layer of the eye that controls the eye's accommodation for viewing objects at varying distances and regulates the flow of aqueous humour through Schlemm's canal. [WP,unvetted]. BTO:0000654 @@ -35137,7 +35014,7 @@ plexiform layer. ciliary muscle http://upload.wikimedia.org/wikipedia/commons/2/28/Gray872.png - + @@ -35156,7 +35033,7 @@ plexiform layer. - + FMA @@ -35297,7 +35174,7 @@ plexiform layer. - + @@ -35349,14 +35226,14 @@ plexiform layer. eyelid https://upload.wikimedia.org/wikipedia/commons/8/84/Eye_makeup.jpg - + - + multiple @@ -35651,7 +35528,7 @@ plexiform layer. - + @@ -35694,14 +35571,14 @@ plexiform layer. iris - + - + XAO @@ -35773,7 +35650,7 @@ plexiform layer. - + @@ -35825,14 +35702,14 @@ plexiform layer. corneal epithelium http://upload.wikimedia.org/wikipedia/commons/6/66/Gray871.png - + - + ISBN:0781772214 @@ -35928,16 +35805,16 @@ plexiform layer. - - + + - - + + @@ -35979,44 +35856,44 @@ plexiform layer. sclera http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg - + - + - + - + - + FMA - + ZFA - + ISBN:0781772214 - + cjm ISBN:0781772214 Wikipedia @@ -36076,7 +35953,7 @@ plexiform layer. - + @@ -36115,14 +35992,14 @@ plexiform layer. ciliary body http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg - + - + ISBN:0781772214 @@ -36170,14 +36047,14 @@ plexiform layer. - + - + @@ -36240,24 +36117,24 @@ plexiform layer. optic choroid http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg - + - + - + MA - + Wikipedia @@ -36357,7 +36234,7 @@ plexiform layer. - + @@ -36406,14 +36283,14 @@ plexiform layer. substantia propria of cornea http://upload.wikimedia.org/wikipedia/commons/6/66/Gray871.png - + - + cjm ISBN:0781772214 Wikipedia @@ -36490,9 +36367,9 @@ plexiform layer. - - - + + + A double layer covering the ciliary body that produces aqueous humor. BTO:0001770 @@ -36512,15 +36389,15 @@ plexiform layer. ciliary epithelium - + - + - + @@ -36533,19 +36410,19 @@ plexiform layer. - + MA - + MP - + Wikipedia @@ -36668,7 +36545,7 @@ plexiform layer. - + @@ -36729,14 +36606,14 @@ plexiform layer. pigmented layer of retina http://upload.wikimedia.org/wikipedia/commons/5/55/Gray881.png - + - + Wikipedia @@ -36840,7 +36717,7 @@ plexiform layer. - + @@ -36874,14 +36751,14 @@ plexiform layer. photoreceptor layer of retina http://upload.wikimedia.org/wikipedia/commons/5/55/Gray881.png - + - + ZFA @@ -37054,7 +36931,7 @@ plexiform layer. - + @@ -37101,14 +36978,14 @@ plexiform layer. outer nuclear layer of retina - + - + soma ZFA @@ -37446,7 +37323,7 @@ plexiform layer. - + @@ -37505,7 +37382,7 @@ plexiform layer. ganglionic layer of retina http://upload.wikimedia.org/wikipedia/commons/5/55/Gray881.png - + @@ -37518,7 +37395,7 @@ plexiform layer. - + FMA @@ -37594,7 +37471,7 @@ plexiform layer. - + @@ -37650,14 +37527,14 @@ plexiform layer. nerve fiber layer of retina - + - + FMA @@ -38035,7 +37912,7 @@ plexiform layer. - + @@ -38071,14 +37948,14 @@ plexiform layer. aqueous humor of eyeball http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg - + - + FMA def states A and P located_in in EHDAA2 VHOG @@ -38260,7 +38137,7 @@ plexiform layer. - + @@ -38284,7 +38161,7 @@ plexiform layer. vitreous body http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg - + @@ -38297,7 +38174,7 @@ plexiform layer. - + neural ectoderm of optic cup ISBN:0781772214 @@ -38432,8 +38309,8 @@ plexiform layer. - - + + @@ -38466,24 +38343,24 @@ plexiform layer. anterior segment of eyeball http://upload.wikimedia.org/wikipedia/commons/b/ba/Cataract_in_human_eye.png - + - + - + FMA - + cjm @@ -38534,8 +38411,8 @@ plexiform layer. - - + + @@ -38565,24 +38442,24 @@ plexiform layer. posterior segment of eyeball http://upload.wikimedia.org/wikipedia/commons/1/1e/Schematic_diagram_of_the_human_eye_en.svg - + - + - + FMA - + cjm @@ -38618,9 +38495,9 @@ plexiform layer. - - - + + + @@ -38670,15 +38547,15 @@ plexiform layer. conjunctiva http://upload.wikimedia.org/wikipedia/commons/5/55/Gray883.png - + - + - + @@ -38691,19 +38568,19 @@ plexiform layer. - + cjm - + MA - + ISBN:0781772214 @@ -38767,7 +38644,7 @@ plexiform layer. - + The most anterior region of the brain including both the telencephalon and diencephalon. @@ -38814,14 +38691,14 @@ plexiform layer. forebrain http://upload.wikimedia.org/wikipedia/commons/5/54/EmbryonicBrain.svg - + - + definitional @@ -38897,14 +38774,14 @@ plexiform layer. - + - + The midbrain is the middle division of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes a ventral part containing the cerebral peduncles and a dorsal tectum containing the corpora quadrigemina and that surrounds the aqueduct of Sylvius connecting the third and fourth ventricles)[GO]. developmental relationships need revised @@ -38957,24 +38834,24 @@ plexiform layer. midbrain http://upload.wikimedia.org/wikipedia/commons/f/f9/Human_brain_inferior_view_description.JPG - + - + - + definitional - + Bgee:AN @@ -39077,14 +38954,14 @@ plexiform layer. - + - + The division of the forebrain that develops from the foremost primary cerebral vesicle. @@ -39147,24 +39024,24 @@ plexiform layer. diencephalon http://upload.wikimedia.org/wikipedia/commons/5/54/EmbryonicBrain.svg - + - + - + definitional - + definitional @@ -39600,7 +39477,7 @@ plexiform layer. - + Ventral part of the midbrain, separated from the hindbrain by the isthmus[ISBN:0471888893]. Subdivision of the midbrain lying anterior to the tectum and posterior to the substantia nigra and cerebral peduncle[FMA] The part of the midbrain extending from the substantia nigra to the cerebral aqueduct in a horizontal section of the midbrain. It forms the floor of the midbrain that surrounds the cerebral aqueduct[WP]. Together, our results reveal a shared basic organization in the tegmental domains of the diencephalon and midbrain of developing lamprey, indicating early appearance of the domain in vertebrate phylogeny.[well established][VHOG] @@ -39640,14 +39517,14 @@ plexiform layer. midbrain tegmentum http://upload.wikimedia.org/wikipedia/commons/b/b6/Gray712.png - + - + ZFA @@ -39826,8 +39703,8 @@ plexiform layer. - - + + @@ -39840,7 +39717,7 @@ plexiform layer. - + @@ -39899,34 +39776,34 @@ plexiform layer. blood vessel http://upload.wikimedia.org/wikipedia/commons/2/29/Circulatory_System_en.svg - + - + - + - + AEO - + EHDAA2 - + GO:0072360 @@ -40285,7 +40162,7 @@ plexiform layer. - + @@ -40298,7 +40175,7 @@ plexiform layer. - + The most posterior of the three principal regions of the brain. In mammals and birds the hindbrain is divided into a rostral metencephalon and a caudal myelencephalon. In zebrafish, with the exception of the cerebellum, the ventral remainder of the metencephalon can be separated only arbitrarily from the more caudal myelencephalic portion of the medulla oblongata (From: Neuroanatomy of the Zebrafish Brain)[ZFA]. Organ component of neuraxis that has as its parts the pons, cerebellum and medulla oblongata[FMA]. @@ -40349,25 +40226,25 @@ plexiform layer. hindbrain http://upload.wikimedia.org/wikipedia/commons/5/54/EmbryonicBrain.svg - + - + - + modified-source-relation ABA - + Bgee:AN @@ -41186,7 +41063,7 @@ plexiform layer. - + Vasculature that is part of the eye region. not part of the eye in ZFA. Note this changed to a blood vessel in ZFA @@ -41207,14 +41084,14 @@ plexiform layer. vasculature of eye - + - + ISBN:0781772214 @@ -41273,7 +41150,7 @@ plexiform layer. - + @@ -41307,14 +41184,14 @@ plexiform layer. musculoskeletal system - + - + check ctenophore @@ -41452,15 +41329,15 @@ plexiform layer. - + - - + + Part of the central nervous system located in the vertebral canal continuous with and caudal to the brain; demarcated from brain by plane of foramen magnum. It is composed of an inner core of gray matter in which nerve cells predominate, and an outer layer of white matter in which myelinated nerve fibers predominate, and surrounds the central canal. (CUMBO). TODO - add superclass to unify with VNC? @@ -41517,34 +41394,34 @@ plexiform layer. spinal cord http://upload.wikimedia.org/wikipedia/commons/5/58/Spinal_cord_direv.svg - + - + - + - + ZFA - + definitional - + definitional @@ -41986,7 +41863,7 @@ plexiform layer. - + @@ -42027,14 +41904,14 @@ plexiform layer. coelemic cavity lumen - + - + definitional @@ -42142,9 +42019,9 @@ plexiform layer. - - - + + + @@ -42199,15 +42076,15 @@ plexiform layer. notochord http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png - + - + - + @@ -42226,19 +42103,19 @@ plexiform layer. - + http://tolweb.org/Chordata/2499 - + ZFA - + EHDAA2 @@ -42323,8 +42200,8 @@ plexiform layer. - - + + Somites are spheres of epithelial cells that form sequentially along the anterior-posterior axis of the embryo through mesenchymal to epithelial transition of the presomitic mesoderm. currently classified as an epithelial vesicle, consistent with EHDAA2 and https://github.com/obophenotype/uberon/wiki/The-neural-crest. Consider making 'somitic mesoderm' a separate term and correlate with regionalization processes. Consider moving ZFA term to 'trunk somite' as it is part of the trunk @@ -42370,11 +42247,11 @@ plexiform layer. somite http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png - + - + @@ -42387,13 +42264,13 @@ plexiform layer. - + GOTAX:0000352 - + ZFA @@ -42506,12 +42383,12 @@ plexiform layer. + + + + - - - - A specialized region of ectoderm found between the neural ectoderm (neural plate) and non-neural ectoderm and composed of highly migratory pluripotent cells that delaminate in early embryonic development from the dorsal neural tube and give rise to an astounding variety of differentiated cell types[MP]. consider including subclasses for pre- and post- migratory (e.g. sheets/paths/streams). @@ -42551,66 +42428,66 @@ plexiform layer. http://upload.wikimedia.org/wikipedia/commons/5/5f/Gray644.png https://upload.wikimedia.org/wikipedia/commons/8/8f/Neural_Crest.png - + - + - + - + - + - + - + XAO https://github.com/obophenotype/uberon/wiki/The-neural-crest - + Hall and others restrict NC to vertebrates but we opt for a less restrictive constraint to avoid inconsistencies when areas such as P1 area of pallium in hagfishes inherit cell lineage from telecephalon-contributing NC cells ISBN:0073040584 - + BTO - + PMID:11523831 - + pre migratory https://github.com/obophenotype/uberon/wiki/The-neural-crest - + PMID:11523831 @@ -42993,14 +42870,14 @@ plexiform layer. - + - + Anatomical system that is involved in the production of hematopoietic cells. Anatomical system that consists of the blood and blood forming tissues.[AAO] @@ -43043,24 +42920,24 @@ plexiform layer. hematopoietic system - + - + - + FMA - + definitional @@ -43125,8 +43002,8 @@ plexiform layer. - - + + @@ -43152,11 +43029,11 @@ plexiform layer. iris epithelium - + - + @@ -43169,13 +43046,13 @@ plexiform layer. - + MA - + MP @@ -43325,7 +43202,7 @@ plexiform layer. - + Ectodermal placode that develops in the head into a part of the sensory nervous system. With a few exceptions (lens, adenohypophyseal), cranial placodes are neurogenic. Do not merge with neurogenic placode Comparisons of developmental gene expression suggest that the anterior ectoderm in amphioxus may be homologous to the vertebrate olfactory placode, the only vertebrate placode with primary, not secondary, neurons @@ -43345,7 +43222,7 @@ plexiform layer. cranial placode - + @@ -43358,7 +43235,7 @@ plexiform layer. - + PMID:11523831 PMID:22512454 @@ -43563,7 +43440,7 @@ plexiform layer. - + @@ -43576,7 +43453,7 @@ plexiform layer. - + The part of the brain that is the morphological boundary between the midbrain and hindbrain and that is the location of an organizing center which patterns the midbrain and hindbrain primordia of the neural plate. consider adding class for organizer. Consider adding separate class for isthmus as a structure Lampreys also have an MHB [midbrain hindbrain boundary], expressing a similar repertoire of regulatory gene cognates as in gnathostomes.[well established][VHOG] @@ -43606,11 +43483,11 @@ plexiform layer. midbrain-hindbrain boundary - + - + @@ -43624,13 +43501,13 @@ plexiform layer. - + ZFA - + ZFA @@ -43795,7 +43672,7 @@ plexiform layer. - + Unsegmented field of paraxial mesoderm present posterior to the most recently formed somite pair, from which somites will form. Unsegmented field of paraxial mesoderm present posterior to the most recently formed somite pair, from which somites will form. Kimmel et al, 1995.[TAO] It is reasonable to assume that the proximate invertebrate ancestor of the vertebrates had an amphioxus-like tail bud in its larval stage. This archetypal tail bud would have (...) (3) lacked any component of mesenchyme cells, (4) budded off new mesodermal segments directly, without any intervening zone of presomitic mesoderm (...). Then, early in vertebrate evolution, epithelium-to-mesenchyme interconversions (and the gene networks for effecting them) became prominent features of development. (...) In any case, conspicuous mesenchymal components tended to be added to the vertebrate tail bud itself. In addition, a mesenchymatous presomitic mesoderm (not a part of the tail bud proper) came to intervene between the tail bud and the forming somites.[well established][VHOG] @@ -43820,14 +43697,14 @@ plexiform layer. presomitic mesoderm - + - + Bgee:AN @@ -44069,7 +43946,7 @@ plexiform layer. - + @@ -44107,7 +43984,7 @@ plexiform layer. eye primordium - + @@ -44120,7 +43997,7 @@ plexiform layer. - + PMID:16496288 XAO @@ -44176,8 +44053,8 @@ plexiform layer. - - + + @@ -44206,24 +44083,24 @@ plexiform layer. optic cup - + - + - + ZFA - + ZFA @@ -44288,7 +44165,7 @@ plexiform layer. - + @@ -44329,7 +44206,7 @@ plexiform layer. lens placode http://upload.wikimedia.org/wikipedia/commons/2/2f/Gray864.png - + @@ -44342,7 +44219,7 @@ plexiform layer. - + ZFA @@ -44406,9 +44283,9 @@ plexiform layer. - - - + + + A region of embryonic ectodermal cells that lie directly above the notochord. During neurulation, they change shape and produce an infolding of the neural plate (the neural fold) that then seals to form the neural tube[XAO]. The earliest recognizable dorsal ectodermal primordium of the central nervous system present near the end of gastrulation before infolding to form the neural keel; consists of a thickened pseudostratified epithelium[ZFA]. The earliest recognizable dorsal ectodermal primordium of the central nervous system present near the end of gastrulation before infolding to form the neural keel; consists of a thickened pseudostratified epithelium. Kimmel et al, 1995.[TAO] (...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...).[well established][VHOG] @@ -44440,34 +44317,34 @@ plexiform layer. neural plate https://upload.wikimedia.org/wikipedia/commons/8/8f/Neural_Crest.png - + - + - + - + GOTAX:0000352 - + Wikipedia - + Bgee:AN @@ -44578,7 +44455,7 @@ plexiform layer. - + The paraxial mesoderm is the mesoderm located bilaterally adjacent to the notochord and neural tube[GO]. Mesoderm lateral to the neural tube and notochord that is divided into cranial and post-cranial portions. The trunk portions further segment into somites.[AAO] Presently, Cephalochordata, Urochordata, and Vertebrata are placed as subphyla of the phylum Chordata, in which the overall organization of embryonic tissues (dorsal hollow nerve cord, ventral digestive tract, axial notochord, and bilateral paraxial mesoderm) is largely conserved. In contrast, the echinoderms and hemichordates are sister groups of the chordates and they lack the notochord and paraxial mesoderm. Thus, the basic mesodermal organization of vertebrates must have appeared first in the common ancestor of the chordates.[well established][VHOG] @@ -44607,7 +44484,7 @@ plexiform layer. paraxial mesoderm http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png - + @@ -44620,7 +44497,7 @@ plexiform layer. - + Bgee:AN @@ -44732,7 +44609,7 @@ plexiform layer. - + @@ -44776,7 +44653,7 @@ plexiform layer. lateral plate mesoderm http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png - + @@ -44789,7 +44666,7 @@ plexiform layer. - + EHDAA2 VHOG @@ -44873,15 +44750,15 @@ plexiform layer. - - + + - + Bilateral groups of cells consisting of three rows: one row of endocardial precursors medially and two rows of myocardical precursors laterally. The two populations fuse at the midline to form the heart rudiment or cone. should probably be merged with heart rudiment. Bilateral groups of cells consisting of three rows: one row of endocardial precursors medially and two rows of myocardical precursors laterally. The two populations fuse at the midline between 21 and 26 somites to form the heart rudiment or cone. Stainier 2001.[TAO] @@ -44901,15 +44778,15 @@ plexiform layer. heart primordium - + - + - + @@ -44922,19 +44799,19 @@ plexiform layer. - + ZFA - + ZFA - + XAO @@ -44989,8 +44866,8 @@ plexiform layer. - - + + Ventral somitic compartment that is a precursor of the axial skeleton[XAO]. Sclerotomes eventually differentiate into the vertebrae and most of the skull. The caudal (posterior) half of one sclerotome fuses with the rostral (anterior) half of the adjacent one to form each vertebra. From their initial location within the somite, the sclerotome cells migrate medially towards the notochord. These cells meet the sclerotome cells from the other side to form the vertebral body. From this vertebral body, sclerotome cells move dorsally and surround the developing spinal cord, forming the vertebral arch[WP]. Skeletogenic portion of somites.[AAO] The vertebrate sclerotome has no equivalent in amphioxus and is a novelty linked with the evolution of the axial skeleton.[well established][VHOG] @@ -45017,11 +44894,11 @@ plexiform layer. sclerotome http://upload.wikimedia.org/wikipedia/commons/9/96/Gray65.png - + - + @@ -45040,13 +44917,13 @@ plexiform layer. - + VHOG:0000680 - + ZFA @@ -45464,7 +45341,7 @@ plexiform layer. - + Mesenchyme that is part of a developing camera-type eye. TODO - change mesenchyme relationships to precursor_of EHDAA2:0000485 @@ -45476,14 +45353,14 @@ plexiform layer. UBERON:0003314 eye mesenchyme - + - + EHDAA2 @@ -46341,7 +46218,7 @@ plexiform layer. - + The part of the coelom in the embryo between the somatopleuric and splanchnopleuric mesoderm; the principal body cavities of the trunk (thoracic, abdominal, and pelvic) arise from this embryonic part of the coelom. consider merging with coelom. TODO - add spatial relationships to halves of LPM. Note the OG places XAO and ZFA coelem terms here. editor note: TODO check ZFA, which appears to be a structure present in adults (...) I regard it unlikely that coeloms of all bilaterian animals are comparable and evolved very early. Considering all these questions, few convincing characters concerning the evolution of body cavities remain to be named. (...) A segmental coelom appears to have evolved at least two times, in Annelida and in Myomerata (Acrania and Craniota).[well established][VHOG] @@ -46357,14 +46234,14 @@ plexiform layer. intraembryonic coelom - + - + Wikipedia @@ -46469,7 +46346,7 @@ plexiform layer. - + The part of the retina that contains neurons and photoreceptor cells[GO]. (...) an essentially similar sequence of events occurs during the embryonic development of the vertebrate eye. The eye initially develops as a single median evagination of the diencephalon that soon bifurcates to form the paired optic vesicles. As each optic vesicle grows towards the body surface, its proximal part narrows as the optic stalk, and its distal part invaginates to form a two-layered optic cup. (...) The outer layer of the optic cup becomes the pigment layer of the retina, whereas the inner layer differentiates into the photoreceptive cells and neuronal layers of the retina.[well established][VHOG] @@ -46501,14 +46378,14 @@ plexiform layer. retinal neural layer - + - + Bgee:AN @@ -46766,7 +46643,7 @@ plexiform layer. - + The layer of undifferentiated, proliferating cells that line the neural tube lumen that is the immediate transformation of the germinal neuroepithelium. consider merging with 'ventricular zone'; note that the MA class probably does not belong here, as this is an embryonic structure The layer of undifferentiated, proliferating cells that line the neural tube lumen @@ -46784,7 +46661,7 @@ plexiform layer. neural tube ventricular layer - + @@ -46797,7 +46674,7 @@ plexiform layer. - + NCBIBook:NBK10047 @@ -46857,7 +46734,7 @@ plexiform layer. - + @@ -46881,7 +46758,7 @@ plexiform layer. neural tube mantle layer - + @@ -46894,7 +46771,7 @@ plexiform layer. - + by division NCBIBook:NBK10047 @@ -46931,7 +46808,7 @@ plexiform layer. - + @@ -46948,14 +46825,14 @@ plexiform layer. neural tube marginal layer - + - + forms from axons @@ -47230,9 +47107,9 @@ plexiform layer. - - - + + + @@ -47265,34 +47142,34 @@ plexiform layer. optic vesicle http://upload.wikimedia.org/wikipedia/commons/e/e0/Gray863.png - + - + - + - + ZFA - + GO-def - + ZFA @@ -47408,8 +47285,8 @@ plexiform layer. - - + + A specific region of the lateral mesoderm that will form the primary beating heart tube. In mammals the primary heart field gives rise to the left ventricle. this term denotes the primary heart field; GO:0003128 denotes the superclass of primary and secondary: specific region of the lateral mesoderm into the area which will form the primary beating heart tube[GO:0003138] XAO:0004185 @@ -47422,24 +47299,24 @@ plexiform layer. UBERON:0004140 primary heart field - + - + - + GO:0003128 - + https://orcid.org/0000-0003-3308-6245 @@ -47498,7 +47375,7 @@ plexiform layer. - + An epithelial tube that will give rise to the mature heart. the paired, longitudinal, endothelial-lined channels formed from the cardiogenic mesoderm in embryonic development; angiogenic cell clusters (aka angioblastic cords) located in a horse-shoe shape configuration in the cardiogenic plate coalesce to form the right and left endocardial heart tubes which then fuse in cephalo-caudal direction to form a single primitive heart tube. AAO:0010411 @@ -47518,14 +47395,14 @@ plexiform layer. heart tube - + - + ZFA-modified @@ -47606,7 +47483,7 @@ plexiform layer. - + @@ -47622,14 +47499,14 @@ plexiform layer. eye muscle - + - + MA @@ -47833,7 +47710,7 @@ plexiform layer. - + A transparent homogeneous acellular layer found between the substantia propria and the endothelial layer of the cornea[MP]. Acellular anatomical structure composed of collagen, Descemet's membrane is secreted as a basement membrane of the corneal endothelium. Located between the stroma and the corneal endothelium, it is approximately 0.15 micrometer thick at 6 months post-fertilization.[ZFIN] @@ -47863,14 +47740,14 @@ plexiform layer. Descemet's membrane https://github.com/obophenotype/uberon/issues/15 - + - + Cline et al @@ -48651,7 +48528,7 @@ plexiform layer. - + Organ consisting of skeletal tissue. Encompasses whole bones, fused bones, cartilaginious elements, teeth, dermal denticles. Organ entity that is typically involved in mechanical support and may have different skeletal tissue compositions at different stages.[VSAO] Organ entity that may have different tissue compositions at different stages and is typically involved in mechanical support.[TAO] @@ -48667,14 +48544,14 @@ plexiform layer. skeletal element - + - + VSAO @@ -48719,7 +48596,7 @@ plexiform layer. - + @@ -48758,14 +48635,14 @@ plexiform layer. UBERON:0004770 articular system - + - + FMA @@ -49672,7 +49549,7 @@ plexiform layer. - + Portion of primordial embryonic connective tissue of the developing head, consisting of mesenchymal cells supported in interlaminar jelly, that derive mostly from the mesoderm and contribute to head connective tissue, bone and musculature in conjunction with cranial neural crest cells. Mesoderm that will give rise, along with cranial neural crest cells, to connective tissue, bone and musculature in the head. (Source: BioGlossary, www.Biology-Text.com)[TAO] EFO:0003492 @@ -49694,14 +49571,14 @@ plexiform layer. head mesenchyme - + - + EHDAA2 @@ -49768,7 +49645,7 @@ plexiform layer. - + Mesenchyme that is part of a developing trunk. EFO:0003485 EHDAA2:0002092 @@ -49784,14 +49661,14 @@ plexiform layer. trunk mesenchyme - + - + EHDAA2 @@ -49814,7 +49691,7 @@ plexiform layer. - + The posterior part of the developing vertebrate hindbrain or the corresponding part of the adult brain composed of the medulla oblongata and a portion of the fourth ventricle; as well as the glossopharyngeal nerve (CN IX), vagus nerve (CN X), accessory nerve (CN XI), hypoglossal nerve (CN XII), and a portion of the vestibulocochlear nerve (CN VIII).[BTO,WP]. The posterior of the two brain vesicles formed by specialization of the rhombencephalon in the developing embryo, it comprises the medulla oblongata. [TFD][VHOG] @@ -49839,14 +49716,14 @@ plexiform layer. myelencephalon http://upload.wikimedia.org/wikipedia/commons/5/54/EmbryonicBrain.svg - + - + definitional @@ -50373,7 +50250,7 @@ plexiform layer. - + Portion of tissue that is part of the eye and gives rise to the mature, fully layered cornea. TAO:0002188 ZFA:0001688 @@ -50381,7 +50258,7 @@ plexiform layer. UBERON:0005427 corneal primordium - + @@ -50400,7 +50277,7 @@ plexiform layer. - + ZFA @@ -50423,7 +50300,7 @@ plexiform layer. - + Multi-tissue structure that arises from the heart rudiment and will become the heart tube. EHDAA2:0001512 EHDAA:424 @@ -50441,14 +50318,14 @@ plexiform layer. primitive heart tube - + - + ZFA @@ -50651,7 +50528,7 @@ plexiform layer. - + A delimited region of dense mesenchyme within looser mesenchyme. AEO:0000148 EHDAA2_RETIRED:0003148 @@ -50661,7 +50538,7 @@ plexiform layer. UBERON:0005856 developing mesenchymal condensation - + @@ -50680,7 +50557,7 @@ plexiform layer. - + AEO-modified-relation @@ -50739,9 +50616,9 @@ plexiform layer. - - - + + + A serous sac which is the aggregate of the conjunctiva plus the conjunctival space. EMAPA:18233 FMA:20291 @@ -50752,15 +50629,15 @@ plexiform layer. UBERON:0005908 conjunctival sac - + - + - + @@ -50773,19 +50650,19 @@ plexiform layer. - + FMA - + HPO:pr - + MA @@ -51040,7 +50917,7 @@ plexiform layer. - + @@ -51063,14 +50940,14 @@ plexiform layer. future diencephalon - + - + EHDAA2 @@ -51253,7 +51130,7 @@ plexiform layer. - + @@ -51277,14 +51154,14 @@ plexiform layer. future spinal cord - + - + EHDAA2 @@ -51321,7 +51198,7 @@ plexiform layer. - + The notochordal plate is the dorsal part of the notochordal process when the ventral portion breaks down. It is continuous laterally with the endoderm that composes the roof of the primitive foregut and is in contact dorsally with the neural tube. The folding off of the notochordal plate gives rise to the notochord. TODO - check ordering; awaiting confirmation from JB The notochordal plate is the dorsal part of the notochordal process when the ventral portion breaks down. It is continuous laterally with the endoderm that composes the roof of the primitive foregut and is in contact dorsally with the neural tube. The folding off of the notochordal plate gives rise to the notochord. [Carson_JL, Dehart_DB, Developmental_Dynamics_(1994)_201:_260-278, Gesteland_K_and_Schoenwolf_GC, Inagaki_T, Morphogenesis_of_the_murine_node_and_notochordal_plate, The_prechordal_plate, Vrablic_T, see_Mueller_F_and_O'Rahilly_R, the_rostral_end_of_the_notochord_and_nearby_median_features_in_staged_human_embryos._Cells_Tissues_Organs_(2003)_173:_1-20_and_Sulik_K][VHOG] @@ -51336,7 +51213,7 @@ plexiform layer. notochordal plate - + @@ -51349,7 +51226,7 @@ plexiform layer. - + EHDAA2 @@ -51386,7 +51263,7 @@ plexiform layer. - + A midline cellular cord formed from the migration of mesenchymal cells from the primitive knot. EHDAA2:0001279 EHDAA:224 @@ -51403,14 +51280,14 @@ plexiform layer. The notochordal process grows cranially until it reaches the prechordal plate, the future site of the mouth. In this area the ectoderm is attached directly to the endoderm without intervening mesoderm. This area is known as the oropharyngeal membrane, and it will break down to become the mouth. At the other end of the primitive streak the ectoderm is also fused directly to the endoderm; this is known as the cloacal membrane (proctodeum), or primordial anus. notochordal process - + - + EHDAA2 @@ -52315,7 +52192,7 @@ plexiform layer. - + A hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood or analogs[GO,modified]. note we reserve the subclass 'heart' from the vertebrate multi-chambered heart. 'The first heart-like organ is believed to have appeared 500my ago in an ancestral bilaterian'. Amniotes: four-chambered heart. Amphibians: two atria, one ventricle, pulmonary; fish: single atrium and ventricle; amphioxus: tubular, non-striated, closed, unidirectional; ascidians: tubular, striated, open, bidirectional; arthropods: tubular, open; C elegans: contractile pharynx; Cnideria: striated muscle cells associated with gastrodermis SPD:0000130 @@ -52330,14 +52207,14 @@ plexiform layer. Gene notes: Bmp, Nkx, Gata primary circulatory organ - + - + GO uses blood circulation generically to include the haemolymphatic fluid of arthropods @@ -52492,8 +52369,8 @@ plexiform layer. - - + + @@ -52520,24 +52397,24 @@ plexiform layer. presumptive hindbrain - + - + - + XAO-abduced - + cjm @@ -52594,7 +52471,7 @@ plexiform layer. - + @@ -52613,14 +52490,14 @@ plexiform layer. presumptive midbrain hindbrain boundary - + - + ZFA @@ -52659,7 +52536,7 @@ plexiform layer. - + @@ -52676,14 +52553,14 @@ plexiform layer. presumptive segmental plate - + - + https://github.com/obophenotype/uberon/wiki/The-neural-crest EDHAA2 @@ -52782,7 +52659,7 @@ plexiform layer. - + @@ -52808,7 +52685,7 @@ plexiform layer. presumptive paraxial mesoderm - + @@ -52824,7 +52701,7 @@ plexiform layer. - + https://github.com/obophenotype/uberon/issues/1277 @@ -52906,7 +52783,7 @@ plexiform layer. - + A neural decussation that is part of a diencephalon. FMA:62446 diencephalon decussation @@ -52914,7 +52791,7 @@ plexiform layer. UBERON:0007425 decussation of diencephalon - + @@ -52927,7 +52804,7 @@ plexiform layer. - + Obol @@ -53002,7 +52879,7 @@ plexiform layer. - + Mesenchyme with little extracellular matrix. AEO:0000146 EHDAA2:0003146 @@ -53010,7 +52887,7 @@ plexiform layer. UBERON:0007524 dense mesenchyme tissue - + @@ -53023,7 +52900,7 @@ plexiform layer. - + AEO @@ -53263,7 +53140,7 @@ plexiform layer. - + An axon tract that is part of a brain. the NIFSTD class 'nerve tract' is classified under 'regional part of brain', so it may seem like it belongs here, but actually includes spinal cord tracts FMA:83848 @@ -53273,14 +53150,14 @@ plexiform layer. UBERON:0007702 tract of brain - + - + cjm @@ -53308,7 +53185,7 @@ plexiform layer. - + Anatomical system that consists of all blood and lymph vessels. consider merging with vasculature The cardiovascular and lymphatic systems, collectively[ncithesaurus:Vascular_System]. @@ -53325,14 +53202,14 @@ plexiform layer. vascular system - + - + MA @@ -53465,7 +53342,7 @@ plexiform layer. - + @@ -53482,14 +53359,14 @@ plexiform layer. UBERON:0009142 entire embryonic mesenchyme - + - + EHDAA2 @@ -53585,8 +53462,8 @@ plexiform layer. - - + + TODO - developmental relationships for lines TAO:0007044 ZFA:0007044 @@ -53596,24 +53473,24 @@ plexiform layer. UBERON:0009615 midbrain hindbrain boundary neural plate - + - + - + ZFA - + https://github.com/obophenotype/uberon/issues/438 Bgee:AN @@ -53647,14 +53524,14 @@ plexiform layer. - + - + @@ -53679,24 +53556,24 @@ plexiform layer. presumptive midbrain - + - + - + ZFA - + ZFA @@ -53742,7 +53619,7 @@ plexiform layer. - + EHDAA2:0002094 trunk and cervical paraxial mesenchyme uberon @@ -53750,14 +53627,14 @@ plexiform layer. UBERON:0009618 trunk paraxial mesoderm - + - + EHDAA2 @@ -53779,7 +53656,7 @@ plexiform layer. - + EFO:0003704 TAO:0005041 ZFA:0005041 @@ -53789,14 +53666,14 @@ plexiform layer. anterior lateral plate mesoderm - + - + ZFA @@ -53852,14 +53729,14 @@ plexiform layer. - + EHDAA2:0001315 EHDAA:1122 uberon UBERON:0009920 optic neural crest - + @@ -53872,7 +53749,7 @@ plexiform layer. - + EHDAA2 @@ -54006,7 +53883,7 @@ plexiform layer. - + @@ -54031,14 +53908,14 @@ plexiform layer. eyeball of camera-type eye - + - + FMA @@ -54079,8 +53956,8 @@ plexiform layer. - - + + Portion of tissue that is dorsolateral to the floor plate and part of the midbrain. DHBA:12322 EFO:0003567 @@ -54094,11 +53971,11 @@ plexiform layer. midbrain basal plate - + - + @@ -54111,13 +53988,13 @@ plexiform layer. - + EHDAA2 - + ZFA @@ -54145,7 +54022,7 @@ plexiform layer. - + Portion of neural tube that gives rise to the midbrain. we follow ZFA in temporally dividing midbrain NT from presumptive midbrain, but in future this may be collapsed TAO:0007039 @@ -54154,14 +54031,14 @@ plexiform layer. UBERON:0010286 midbrain neural tube - + - + ZFA @@ -54188,7 +54065,7 @@ plexiform layer. - + @@ -54204,14 +54081,14 @@ plexiform layer. UBERON:0010312 immature eye - + - + definitional @@ -54481,8 +54358,8 @@ plexiform layer. - - + + Anatomical cluster consisting of the skeletal elements (i.e. bone elements, cartilage elements, cartilage condensations) that are part of an individual subdivision of the organism. Excludes joints. Anatomical cluster consisting of the skeletal elements that are part of the skeleton.[VSAO] FMA:23879 @@ -54495,11 +54372,11 @@ plexiform layer. subdivision of skeleton - + - + @@ -54512,13 +54389,13 @@ plexiform layer. - + UBERONREF:0000003 - + VSAO @@ -54595,7 +54472,7 @@ plexiform layer. - + Subdivision of the skeletal system which consists of the postcranial axial skeleton plus associated joints. axial skeletal system FMA:302077 @@ -54605,7 +54482,7 @@ plexiform layer. postcranial axial skeletal system http://purl.obolibrary.org/obo/uberon/docs/The-axial-skeleton - + @@ -54618,7 +54495,7 @@ plexiform layer. - + cjm @@ -54730,7 +54607,7 @@ plexiform layer. - + Muscles within the eye (bulbus oculi).[AAO] AAO:0010038 EMAPA:18808 @@ -54741,14 +54618,14 @@ plexiform layer. UBERON:0011222 intra-ocular muscle - + - + EMAPA @@ -55018,7 +54895,7 @@ plexiform layer. - + @@ -55060,7 +54937,7 @@ plexiform layer. anterior uvea - + @@ -55073,7 +54950,7 @@ plexiform layer. - + MP @@ -55849,7 +55726,7 @@ plexiform layer. - + @@ -55872,7 +55749,7 @@ plexiform layer. UBERON:0016887 entire extraembryonic component - + @@ -55885,7 +55762,7 @@ plexiform layer. - + AEO @@ -56637,196 +56514,6 @@ plexiform layer. - - - - - - - - - example to be eventually removed - example to be eventually removed - - - - - - - - failed exploratory term - The term was used in an attempt to structure part of the ontology but in retrospect failed to do a good job - Person:Alan Ruttenberg - failed exploratory term - - - - - - - - metadata complete - Class has all its metadata, but is either not guaranteed to be in its final location in the asserted IS_A hierarchy or refers to another class that is not complete. - metadata complete - - - - - - - - organizational term - Term created to ease viewing/sort terms for development purpose, and will not be included in a release - organizational term - - - - - - - - ready for release - Class has undergone final review, is ready for use, and will be included in the next release. Any class lacking "ready_for_release" should be considered likely to change place in hierarchy, have its definition refined, or be obsoleted in the next release. Those classes deemed "ready_for_release" will also derived from a chain of ancestor classes that are also "ready_for_release." - ready for release - - - - - - - - metadata incomplete - Class is being worked on; however, the metadata (including definition) are not complete or sufficiently clear to the branch editors. - metadata incomplete - - - - - - - - uncurated - Nothing done yet beyond assigning a unique class ID and proposing a preferred term. - uncurated - - - - - - - - pending final vetting - All definitions, placement in the asserted IS_A hierarchy and required minimal metadata are complete. The class is awaiting a final review by someone other than the term editor. - pending final vetting - - - - - - - - placeholder removed - placeholder removed - - - - - - - - terms merged - An editor note should explain what were the merged terms and the reason for the merge. - terms merged - - - - - - - - term imported - This is to be used when the original term has been replaced by a term imported from an other ontology. An editor note should indicate what is the URI of the new term to use. - term imported - - - - - - - - term split - This is to be used when a term has been split in two or more new terms. An editor note should indicate the reason for the split and indicate the URIs of the new terms created. - term split - - - - - - - - universal - Hard to give a definition for. Intuitively a "natural kind" rather than a collection of any old things, which a class is able to be, formally. At the meta level, universals are defined as positives, are disjoint with their siblings, have single asserted parents. - Alan Ruttenberg - A Formal Theory of Substances, Qualities, and Universals, http://ontology.buffalo.edu/bfo/SQU.pdf - universal - - - - - - - - defined class - A defined class is a class that is defined by a set of logically necessary and sufficient conditions but is not a universal - "definitions", in some readings, always are given by necessary and sufficient conditions. So one must be careful (and this is difficult sometimes) to distinguish between defined classes and universal. - Alan Ruttenberg - defined class - - - - - - - - named class expression - A named class expression is a logical expression that is given a name. The name can be used in place of the expression. - named class expressions are used in order to have more concise logical definition but their extensions may not be interesting classes on their own. In languages such as OWL, with no provisions for macros, these show up as actuall classes. Tools may with to not show them as such, and to replace uses of the macros with their expansions - Alan Ruttenberg - named class expression - - - - - - - - to be replaced with external ontology term - Terms with this status should eventually replaced with a term from another ontology. - Alan Ruttenberg - group:OBI - to be replaced with external ontology term - - - - - - - - requires discussion - A term that is metadata complete, has been reviewed, and problems have been identified that require discussion before release. Such a term requires editor note(s) to identify the outstanding issues. - Alan Ruttenberg - group:OBI - requires discussion - - - - - + + symbol + @@ -75,34 +77,7 @@ - definition - - The official definition, explaining the meaning of a class or property. Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions. - 2012-04-05: -Barry Smith - -The official OBI definition, explaining the meaning of a class or property: 'Shall be Aristotelian, formalized and normalized. Can be augmented with colloquial definitions' is terrible. - -Can you fix to something like: - -A statement of necessary and sufficient conditions explaining the meaning of an expression referring to a class or property. - -Alan Ruttenberg - -Your proposed definition is a reasonable candidate, except that it is very common that necessary and sufficient conditions are not given. Mostly they are necessary, occasionally they are necessary and sufficient or just sufficient. Often they use terms that are not themselves defined and so they effectively can't be evaluated by those criteria. - -On the specifics of the proposed definition: - -We don't have definitions of 'meaning' or 'expression' or 'property'. For 'reference' in the intended sense I think we use the term 'denotation'. For 'expression', I think we you mean symbol, or identifier. For 'meaning' it differs for class and property. For class we want documentation that let's the intended reader determine whether an entity is instance of the class, or not. For property we want documentation that let's the intended reader determine, given a pair of potential relata, whether the assertion that the relation holds is true. The 'intended reader' part suggests that we also specify who, we expect, would be able to understand the definition, and also generalizes over human and computer reader to include textual and logical definition. - -Personally, I am more comfortable weakening definition to documentation, with instructions as to what is desirable. - -We also have the outstanding issue of how to aim different definitions to different audiences. A clinical audience reading chebi wants a different sort of definition documentation/definition from a chemistry trained audience, and similarly there is a need for a definition that is adequate for an ontologist to work with. - PERSON:Daniel Schober - GROUP:OBI:<http://purl.obolibrary.org/obo/obi> - definition - definition @@ -110,19 +85,12 @@ We also have the outstanding issue of how to aim different definitions to differ - editor note - - An administrative note intended for its editor. It may not be included in the publication version of the ontology, so it should contain nothing necessary for end users to understand the ontology. - PERSON:Daniel Schober - GROUP:OBI:<http://purl.obofoundry.org/obo/obi> IAO:0000116 uberon editor_note true editor_note - editor note - editor note @@ -147,13 +115,7 @@ We also have the outstanding issue of how to aim different definitions to differ - - has obsolescence reason - Relates an annotation property to an obsolescence reason. The values of obsolescence reasons come from a list of predefined terms, instances of the class obsolescence reason specification. - PERSON:Alan Ruttenberg - PERSON:Melanie Courtot - has obsolescence reason - + @@ -166,12 +128,6 @@ We also have the outstanding issue of how to aim different definitions to differ - term tracker item - the URI for an OBI Terms ticket at sourceforge, such as https://sourceforge.net/p/obi/obi-terms/772/ - - An IRI or similar locator for a request or discussion of an ontology term. - Person: Jie Zheng, Chris Stoeckert, Alan Ruttenberg - Person: Jie Zheng, Chris Stoeckert, Alan Ruttenberg IAO:0000233 external uberon @@ -179,9 +135,7 @@ We also have the outstanding issue of how to aim different definitions to differ true true term_tracker_item - The 'tracker item' can associate a tracker with a specific ontology term. term tracker item - term tracker item @@ -189,15 +143,7 @@ We also have the outstanding issue of how to aim different definitions to differ - expand expression to - ObjectProperty: RO_0002104 -Label: has plasma membrane part -Annotations: IAO_0000424 "http://purl.obolibrary.org/obo/BFO_0000051 some (http://purl.org/obo/owl/GO#GO_0005886 and http://purl.obolibrary.org/obo/BFO_0000051 some ?Y)" - - A macro expansion tag applied to an object property (or possibly a data property) which can be used by a macro-expansion engine to generate more complex expressions from simpler ones - Chris Mungall expand expression to - expand expression to @@ -229,16 +175,14 @@ Annotations: IAO_0000424 "http://purl.obolibrary.org/obo/BFO_0000051 some ( - has ontology root term - Ontology annotation property. Relates an ontology to a term that is a designated root term of the ontology. Display tools like OLS can use terms annotated with this property as the starting point for rendering the ontology class hierarchy. There can be more than one root. - Nicolas Matentzoglu IAO:0000700 + external uberon has_ontology_root_term + true true has_ontology_root_term has ontology root term - has ontology root term preferred_root @@ -253,14 +197,7 @@ Annotations: IAO_0000424 "http://purl.obolibrary.org/obo/BFO_0000051 some ( - term replaced by - - Use on obsolete terms, relating the term to another term that can be used as a substitute - Person:Alan Ruttenberg - Person:Alan Ruttenberg - Add as annotation triples in the granting ontology term replaced by - term replaced by @@ -1433,12 +1370,6 @@ WHERE { - - - - - - @@ -1503,6 +1434,12 @@ WHERE { + + + + + + @@ -2070,7 +2007,7 @@ A continuant cannot have an occurrent as part: use 'participates in'. An example is: translation preceded_by transcription; aging preceded_by development (not however death preceded_by aging). Where derives_from links classes of continuants, preceded_by links classes of processes. Clearly, however, these two relations are not independent of each other. Thus if cells of type C1 derive_from cells of type C, then any cell division involving an instance of C1 in a given lineage is preceded_by cellular processes involving an instance of C. The assertion P preceded_by P1 tells us something about Ps in general: that is, it tells us something about what happened earlier, given what we know about what happened later. Thus it does not provide information pointing in the opposite direction, concerning instances of P1 in general; that is, that each is such as to be succeeded by some instance of P. Note that an assertion to the effect that P preceded_by P1 is rather weak; it tells us little about the relations between the underlying instances in virtue of which the preceded_by relation obtains. Typically we will be interested in stronger relations, for example in the relation immediately_preceded_by, or in relations which combine preceded_by with a condition to the effect that the corresponding instances of P and P1 share participants, or that their participants are connected by relations of derivation, or (as a first step along the road to a treatment of causality) that the one process in some way affects (for example, initiates or regulates) the other. is preceded by preceded_by - http://www.obofoundry.org/ro/#OBO_REL:preceded_by + http://www.obofoundry.org/ro/#OBO_REL:preceded_by BFO:0000062 external uberon @@ -2502,24 +2439,6 @@ A continuant cannot have an occurrent as part: use 'participates in'. - - - - This document is about information artifacts and their representations - - A (currently) primitive relation that relates an information artifact to an entity. - 7/6/2009 Alan Ruttenberg. Following discussion with Jonathan Rees, and introduction of "mentions" relation. Weaken the is_about relationship to be primitive. - -We will try to build it back up by elaborating the various subproperties that are more precisely defined. - -Some currently missing phenomena that should be considered "about" are predications - "The only person who knows the answer is sitting beside me" , Allegory, Satire, and other literary forms that can be topical without explicitly mentioning the topic. - person:Alan Ruttenberg - Smith, Ceusters, Ruttenberg, 2000 years of philosophy - is about - - - - @@ -2600,7 +2519,7 @@ Some currently missing phenomena that should be considered "about" are a relation between a process and a continuant, in which the continuant is somehow involved in the process Has_participant is a primitive instance-level relation between a process, a continuant, and a time at which the continuant participates in some way in the process. The relation obtains, for example, when this particular process of oxygen exchange across this particular alveolar membrane has_participant this particular sample of hemoglobin at this particular time. has_participant - http://www.obofoundry.org/ro/#OBO_REL:has_participant + http://www.obofoundry.org/ro/#OBO_REL:has_participant RO:0000057 external has_participant @@ -2783,43 +2702,18 @@ Some currently missing phenomena that should be considered "about" are - - - - - - - - - - - contained in - Containment is location not involving parthood, and arises only where some immaterial continuant is involved. - Containment obtains in each case between material and immaterial continuants, for instance: lung contained_in thoracic cavity; bladder contained_in pelvic cavity. Hence containment is not a transitive relation. If c part_of c1 at t then we have also, by our definition and by the axioms of mereology applied to spatial regions, c located_in c1 at t. Thus, many examples of instance-level location relations for continuants are in fact cases of instance-level parthood. For material continuants location and parthood coincide. Containment is location not involving parthood, and arises only where some immaterial continuant is involved. To understand this relation, we first define overlap for continuants as follows: c1 overlap c2 at t =def for some c, c part_of c1 at t and c part_of c2 at t. The containment relation on the instance level can then be defined (see definition): - Intended meaning: -domain: material entity -range: spatial region or site (immaterial continuant) - - contained_in - - - contained in - - - - contains - RO:0001019 uberon contains - contains contains - contains + obsolete contains + + true @@ -2842,7 +2736,7 @@ range: spatial region or site (immaterial continuant) Most location relations will only hold at certain times, but this is difficult to specify in OWL. See http://purl.obolibrary.org/obo/ro/docs/temporal-semantics/ located_in - http://www.obofoundry.org/ro/#OBO_REL:located_in + http://www.obofoundry.org/ro/#OBO_REL:located_in RO:0001025 uberon located_in @@ -6918,16 +6812,6 @@ For example, A and B may be gene products and binding of B by A positively regul - - - - A relationship that holds between two entities, where the entities exhibit a statistical dependence relationship. The entities may be statistical variables, or they may be other kinds of entities such as diseases, chemical entities or processes. - Groups both positive and negative correlation - correlated with - - - - @@ -7457,27 +7341,13 @@ For example, A and B may be gene products and binding of B by A positively regul A diagnostic testing device utilizes a specimen means that the diagnostic testing device is capable of an assay, and this assay a specimen as its input. See github ticket https://github.com/oborel/obo-relations/issues/497 - 2021-11-08T12:00:00Z + 2021-11-08T12:00:00Z utilizes device utilizes material - - - - - - - A relation between entities in which one increases or decreases as the other does the same. - directly correlated with - - positively correlated with - - - - @@ -8152,7 +8022,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + @@ -8168,7 +8038,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process multicellular anatomical structure - + @@ -8180,7 +8050,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + There is a cost to burying this in PATO. We lose that we could relax the cardinality assertion to subClassOf has_part some cell. I'm sure having this axiom inherited would come in handy. DOS @@ -8229,6 +8099,43 @@ MH: sexual subtypes should probably be logically defined based on sexual process + + + + Any molecular entity that contains carbon. + chebi_ontology + organic compounds + organic entity + organic molecular entities + CHEBI:50860 + + + + + Any molecular entity that contains carbon. + ANON:ANON + + + + + organic compounds + ChEBI: + + + + + organic entity + ChEBI: + + + + + organic molecular entities + ChEBI: + + + + @@ -8533,9 +8440,9 @@ MH: sexual subtypes should probably be logically defined based on sexual process FMA:86475 MESH:D006412 VHOG:0001485 - HSC blood forming stem cell hemopoietic stem cell + HSC colony forming unit hematopoietic @@ -8552,6 +8459,12 @@ MH: sexual subtypes should probably be logically defined based on sexual process PMID:19022770 http://en.wikipedia.org/wiki/Hematopoietic_stem_cell + + + + HSC + + @@ -8670,6 +8583,12 @@ MH: sexual subtypes should probably be logically defined based on sexual process http://en.wikipedia.org/wiki/Monoblast http://www.copewithcytokines.de + + + + CFU-M + + @@ -8725,10 +8644,10 @@ MH: sexual subtypes should probably be logically defined based on sexual process A progenitor cell committed to myeloid lineage, including the megakaryocyte and erythroid lineages. BTO:0004730 - CMP common myeloid precursor CFU-GEMM CFU-S + CMP colony forming unit granulocyte, erythrocyte, macrophage, and megakaryocyte multipotential myeloid stem cell myeloid stem cell @@ -8753,21 +8672,24 @@ MH: sexual subtypes should probably be logically defined based on sexual process - - CMP + + CFU-GEMM ISBN:0878932437 + - CFU-GEMM + CFU-S ISBN:0878932437 + - CFU-S + CMP ISBN:0878932437 + @@ -8820,10 +8742,10 @@ MH: sexual subtypes should probably be logically defined based on sexual process A oligopotent progenitor cell committed to the lymphoid lineage. - CLP common lymphocyte precursor common lymphocyte progenitor common lymphoid precursor + CLP ELP committed lymphopoietic stem cell early lymphocyte progenitor @@ -8849,6 +8771,18 @@ MH: sexual subtypes should probably be logically defined based on sexual process PMID:10407577 PMID:16551251 + + + + CLP + + + + + + ELP + + @@ -8971,6 +8905,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process epithelial cell + https://www.swissbiopics.org/api/image/Epithelial_cells.svg @@ -9501,10 +9436,10 @@ MH: sexual subtypes should probably be logically defined based on sexual process BTO:0002625 BTO:0003298 FMA:70546 - BMSC bone marrow stromal cells colony-forming unit-fibroblast marrow stromal cells + BMSC CFU-F MSC mesenchymal precursor cell @@ -9543,11 +9478,24 @@ MH: sexual subtypes should probably be logically defined based on sexual process marrow stromal cells PMID:11378515 + + + + BMSC + + + + + + CFU-F + + MSC PMID:11378515 + @@ -9625,7 +9573,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process A cell capable of processing and presenting lipid and protein antigens to T cells in order to initiate an immune response. - APC + APC Note change of name; nearly all somatic cells can present antigens to T cells via MHC Class I complexes leading to effector responses, but professional antigen presenting cells constitutively express MHC Class II as well as costimulatory molecules, and thus can initiate immune responses via T cells. professional antigen presenting cell @@ -9637,6 +9585,12 @@ MH: sexual subtypes should probably be logically defined based on sexual process GOC:add ISBN:0781735149 + + + + APC + + @@ -9906,6 +9860,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process muscle fiber myocyte muscle cell + https://www.swissbiopics.org/api/image/Muscle_cells.svg @@ -10068,6 +10023,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process CALOHA:TS-0868 FMA:86740 photoreceptor cell + https://www.swissbiopics.org/api/image/Photoreceptor_cell.svg @@ -10515,7 +10471,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process A cell derived from the specialized ectoderm flanking each side of the embryonic neural plate, which after the closure of the neural tube, forms masses of cells that migrate out from the dorsal aspect of the neural tube to spread throughout the body. - MESH:A16.254.600 + doi:10.1016/j.stem.2015.02.017 @@ -11055,6 +11011,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process These cells are also reportedly CD4-negative and CD200-positive. They are also capable of producing CD40L and IFN-gamma. neuron + https://www.swissbiopics.org/api/image/Neuron_cells.svg @@ -11194,6 +11151,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process metazoan cell animal cell + https://www.swissbiopics.org/api/image/Animal_cells.svg @@ -11290,12 +11248,12 @@ MH: sexual subtypes should probably be logically defined based on sexual process A hematopoietic progenitor cell that is committed to the granulocyte and monocyte lineages. These cells are CD123-positive, and do not express Gata1 or Gata2 but do express C/EBPa, and Pu.1. CFU-C , Colony forming unit in culture - CFU-GM - GMP colony forming unit granulocyte macrophage granulocyte-macrophage progenitor granulocyte/monocyte precursor granulocyte/monocyte progenitor + CFU-GM + GMP Originally described in the dendritic cell ontology (DC_CL:0000042)(PMID:19243617). GMPs are reportedly CD16-positive, CD32-positive, CD34-positive, CD38-positive, CD45RA-positive, CD110-negative, CD117-positive, CD123-positive, and SCA1-negative. granulocyte monocyte progenitor cell @@ -11326,7 +11284,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - CFU-GM + colony forming unit granulocyte macrophage ISBN:0721601464 PMCID:PMC2213186 PMCID:PMC548021 @@ -11334,26 +11292,28 @@ MH: sexual subtypes should probably be logically defined based on sexual process - GMP + granulocyte-macrophage progenitor ISBN:0721601464 PMCID:PMC2213186 PMCID:PMC548021 - - colony forming unit granulocyte macrophage + + CFU-GM ISBN:0721601464 PMCID:PMC2213186 PMCID:PMC548021 + - - granulocyte-macrophage progenitor + + GMP ISBN:0721601464 PMCID:PMC2213186 PMCID:PMC548021 + @@ -12256,24 +12216,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process Most markers only described for human pro NK cells. pro-NK cell - - - - null cell - PMID:11532393 - - - - - preNK cell - PMID:11532393 - - - - - - true - @@ -12294,6 +12236,24 @@ MH: sexual subtypes should probably be logically defined based on sexual process PMID:15032583 PMID:15766674 + + + + null cell + PMID:11532393 + + + + + preNK cell + PMID:11532393 + + + + + + true + @@ -15763,32 +15723,32 @@ MH: sexual subtypes should probably be logically defined based on sexual process - - + + A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures. Wikipedia:Collagen cellular_component GO:0005581 collagen trimer - + - + - + PMID:12382326 - + PMID:12382326 @@ -17149,6 +17109,102 @@ MH: sexual subtypes should probably be logically defined based on sexual process + + + + + The multiplication or reproduction of cells, resulting in the expansion of a cell population. + + biological_process + cell proliferation + GO:0008283 + + + + + + + This term was moved out from being a child of 'cellular process' because it is a cell population-level process, and cellular processes are restricted to those processes that involve individual cells. Also note that this term is intended to be used for the proliferation of cells within a multicellular organism, not for the expansion of a population of single-celled organisms. + cell population proliferation + + + + + The multiplication or reproduction of cells, resulting in the expansion of a cell population. + GOC:mah + GOC:mb + + + + + + + + + The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. + jl + 2012-10-17T15:52:18Z + GO:0044274 + GO:0044711 + formation + Wikipedia:Anabolism + anabolism + biosynthesis + synthesis + multicellular organismal biosynthetic process + biological_process + single-organism biosynthetic process + GO:0009058 + + + + biosynthetic process + + + + + The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. + GOC:curators + ISBN:0198547684 + + + + + + + + + + + The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. + https://github.com/geneontology/go-ontology/issues/15249 + https://github.com/geneontology/go-ontology/issues/25418 + GO:0043284 + biopolymer biosynthetic process + macromolecule anabolism + macromolecule biosynthesis + macromolecule formation + macromolecule synthesis + biological_process + GO:0009059 + + macromolecule biosynthetic process + + + + + The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. + GOC:mah + + + + + biopolymer biosynthetic process + GOC:mtg_chebi_dec09 + + + + @@ -17608,9 +17664,10 @@ MH: sexual subtypes should probably be logically defined based on sexual process - - The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, translation and maturation for protein-coding genes. + + The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, as well as translation and maturation for protein-coding genes. https://github.com/geneontology/go-ontology/issues/22557 + https://github.com/geneontology/go-ontology/issues/25419 Wikipedia:Gene_expression biological_process GO:0010467 @@ -17620,7 +17677,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, translation and maturation for protein-coding genes. + The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, as well as translation and maturation for protein-coding genes. GOC:txnOH-2018 PMID:25934543 PMID:31580950 @@ -18493,6 +18550,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process + @@ -20401,6 +20459,58 @@ MH: sexual subtypes should probably be logically defined based on sexual process + + + + + + The chemical reactions and pathways by which individual cells transform chemical substances. + cellular metabolism + biological_process + intermediary metabolism + GO:0044237 + + This term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term. + cellular metabolic process + + + + + The chemical reactions and pathways by which individual cells transform chemical substances. + GOC:go_curators + + + + + intermediary metabolism + GOC:mah + + + + + + + + + + The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. + cellular anabolism + cellular biosynthesis + cellular formation + cellular synthesis + biological_process + GO:0044249 + cellular biosynthetic process + + + + + The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. + GOC:jl + + + + @@ -22483,6 +22593,46 @@ MH: sexual subtypes should probably be logically defined based on sexual process + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways involving an organic substance, any molecular entity containing carbon. + mah + 2010-03-08T03:32:18Z + organic molecular entity metabolic process + organic molecular entity metabolism + organic substance metabolism + biological_process + GO:0071704 + organic substance metabolic process + + + + + The chemical reactions and pathways involving an organic substance, any molecular entity containing carbon. + GOC:mah + + + + @@ -23448,6 +23598,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process + A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex but below that of an anatomical system. Or, a substance produced by a cellular organism with granularity above the level of a protein complex. kmv 2019-08-12T18:01:37Z @@ -23628,6 +23779,78 @@ MH: sexual subtypes should probably be logically defined based on sexual process + + + + + + + + + + + + + + + + + + + + + + + The chemical reactions and pathways resulting in the formation of an organic substance, any molecular entity containing carbon. + pr + 2012-11-05T11:04:40Z + organic molecular entity anabolism + organic molecular entity biosynthesis + organic molecular entity biosynthetic process + organic molecular entity formation + organic molecular entity synthesis + organic substance anabolism + organic substance biosynthesis + organic substance formation + organic substance synthesis + biological_process + GO:1901576 + organic substance biosynthetic process + + + + + The chemical reactions and pathways resulting in the formation of an organic substance, any molecular entity containing carbon. + GOC:TermGenie + GOC:pr + + + + + organic molecular entity anabolism + GOC:TermGenie + + + + + organic molecular entity biosynthesis + GOC:TermGenie + + + + + organic molecular entity formation + GOC:TermGenie + + + + + organic molecular entity synthesis + GOC:TermGenie + + + + @@ -28206,8 +28429,8 @@ MH: sexual subtypes should probably be logically defined based on sexual process - - + + @@ -28258,11 +28481,11 @@ MH: sexual subtypes should probably be logically defined based on sexual process tendon http://upload.wikimedia.org/wikipedia/commons/3/3c/Achilles-tendon.jpg - + - + @@ -28275,13 +28498,13 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + OG - + AEO @@ -29272,7 +29495,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + @@ -29308,14 +29531,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process gastrula stage - + - + BILS @@ -29536,7 +29759,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + @@ -29609,7 +29832,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process https://github.com/obophenotype/uberon/issues/661 http://upload.wikimedia.org/wikipedia/commons/0/06/Mouth_illustration-Otis_Archives.jpg - + @@ -29622,7 +29845,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + exceptions in some taxa @@ -29931,7 +30154,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + @@ -29973,14 +30196,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process organism substance - + - + this relationship may be too strong and may be weakened in future @@ -31212,7 +31435,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + Primary germ layer that is the outer of the embryo's three germ layers and gives rise to epidermis and neural tissue. Primary germ layer that is the outer of the embryonic germ layers and gives rise to epidermis and neural tissue.[AAO] The Bilateria are triploblastic (with true endoderm, mesoderm, and ectoderm) (...).[well established][VHOG] @@ -31250,14 +31473,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process ectoderm http://upload.wikimedia.org/wikipedia/commons/1/19/Gray32.png - + - + Bgee:AN @@ -31310,7 +31533,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + Primary germ layer that lies remote from the surface of the embryo and gives rise to internal tissues such as gut. The Bilateria are triploblastic (with true endoderm, mesoderm, and ectoderm) (...).[well established][VHOG] endodermal @@ -31347,14 +31570,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process http://upload.wikimedia.org/wikipedia/commons/c/c0/Endoderm2.png http://upload.wikimedia.org/wikipedia/commons/d/df/Gray10.png - + - + Bgee:AN @@ -31399,7 +31622,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + The middle germ layer of the embryo, between the endoderm and ectoderm. Primary germ layer that is the middle of the embryonic germ layers.[AAO] @@ -31444,7 +31667,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process mesoderm http://upload.wikimedia.org/wikipedia/commons/e/e8/Mesoderm.png - + @@ -31457,7 +31680,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + Bgee:AN @@ -31780,8 +32003,8 @@ MH: sexual subtypes should probably be logically defined based on sexual process - - + + @@ -31817,24 +32040,24 @@ MH: sexual subtypes should probably be logically defined based on sexual process eye - + - + - + PMID:21062451 - + PMID:21062451 @@ -32441,7 +32664,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + @@ -32496,14 +32719,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process http://upload.wikimedia.org/wikipedia/commons/b/b2/TE-Nervous_system_diagram.svg http://upload.wikimedia.org/wikipedia/commons/b/ba/Nervous_system_diagram.png - + - + Bgee:AN @@ -32591,7 +32814,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the neural tube derivatives: the brain and spinal cord. In invertebrates it includes central ganglia plus nerve cord. Part of the nervous system which includes the brain and spinal cord.[AAO] @@ -32638,7 +32861,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process central nervous system - + @@ -32652,7 +32875,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + Bgee:AN @@ -33519,7 +33742,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + Skeletal element that is composed of bone tissue. @@ -33569,14 +33792,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process bone element - + - + VSAO-modified @@ -33687,7 +33910,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + A tube extending from the mouth to the anus. @@ -33727,14 +33950,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process digestive tract - + - + NCBIBook:NBK10107 @@ -34325,7 +34548,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + @@ -34361,14 +34584,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process musculoskeletal system - + - + check ctenophore @@ -34431,9 +34654,9 @@ MH: sexual subtypes should probably be logically defined based on sexual process - - - + + + @@ -34488,15 +34711,15 @@ MH: sexual subtypes should probably be logically defined based on sexual process notochord http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png - + - + - + @@ -34515,19 +34738,19 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + http://tolweb.org/Chordata/2499 - + ZFA - + EHDAA2 @@ -34612,8 +34835,8 @@ MH: sexual subtypes should probably be logically defined based on sexual process - - + + Somites are spheres of epithelial cells that form sequentially along the anterior-posterior axis of the embryo through mesenchymal to epithelial transition of the presomitic mesoderm. currently classified as an epithelial vesicle, consistent with EHDAA2 and https://github.com/obophenotype/uberon/wiki/The-neural-crest. Consider making 'somitic mesoderm' a separate term and correlate with regionalization processes. Consider moving ZFA term to 'trunk somite' as it is part of the trunk @@ -34659,11 +34882,11 @@ MH: sexual subtypes should probably be logically defined based on sexual process somite http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png - + - + @@ -34676,13 +34899,13 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + GOTAX:0000352 - + ZFA @@ -34859,12 +35082,12 @@ MH: sexual subtypes should probably be logically defined based on sexual process - - - - - - + + + + + + A specialized region of ectoderm found between the neural ectoderm (neural plate) and non-neural ectoderm and composed of highly migratory pluripotent cells that delaminate in early embryonic development from the dorsal neural tube and give rise to an astounding variety of differentiated cell types[MP]. consider including subclasses for pre- and post- migratory (e.g. sheets/paths/streams). @@ -34904,66 +35127,66 @@ MH: sexual subtypes should probably be logically defined based on sexual process http://upload.wikimedia.org/wikipedia/commons/5/5f/Gray644.png https://upload.wikimedia.org/wikipedia/commons/8/8f/Neural_Crest.png - + - + - + - + - + - + - + XAO https://github.com/obophenotype/uberon/wiki/The-neural-crest - + Hall and others restrict NC to vertebrates but we opt for a less restrictive constraint to avoid inconsistencies when areas such as P1 area of pallium in hagfishes inherit cell lineage from telecephalon-contributing NC cells ISBN:0073040584 - + BTO - + PMID:11523831 - + pre migratory https://github.com/obophenotype/uberon/wiki/The-neural-crest - + PMID:11523831 @@ -35318,7 +35541,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + @@ -35376,14 +35599,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process bone marrow http://upload.wikimedia.org/wikipedia/commons/7/74/Gray72-en.svg - + - + FMA MA @@ -35654,14 +35877,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + - + Anatomical system that is involved in the production of hematopoietic cells. @@ -35705,24 +35928,24 @@ MH: sexual subtypes should probably be logically defined based on sexual process hematopoietic system - + - + - + FMA - + definitional @@ -36188,7 +36411,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + Unsegmented field of paraxial mesoderm present posterior to the most recently formed somite pair, from which somites will form. Unsegmented field of paraxial mesoderm present posterior to the most recently formed somite pair, from which somites will form. Kimmel et al, 1995.[TAO] It is reasonable to assume that the proximate invertebrate ancestor of the vertebrates had an amphioxus-like tail bud in its larval stage. This archetypal tail bud would have (...) (3) lacked any component of mesenchyme cells, (4) budded off new mesodermal segments directly, without any intervening zone of presomitic mesoderm (...). Then, early in vertebrate evolution, epithelium-to-mesenchyme interconversions (and the gene networks for effecting them) became prominent features of development. (...) In any case, conspicuous mesenchymal components tended to be added to the vertebrate tail bud itself. In addition, a mesenchymatous presomitic mesoderm (not a part of the tail bud proper) came to intervene between the tail bud and the forming somites.[well established][VHOG] @@ -36213,14 +36436,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process presomitic mesoderm - + - + Bgee:AN @@ -36450,9 +36673,9 @@ MH: sexual subtypes should probably be logically defined based on sexual process - - - + + + A region of embryonic ectodermal cells that lie directly above the notochord. During neurulation, they change shape and produce an infolding of the neural plate (the neural fold) that then seals to form the neural tube[XAO]. The earliest recognizable dorsal ectodermal primordium of the central nervous system present near the end of gastrulation before infolding to form the neural keel; consists of a thickened pseudostratified epithelium[ZFA]. The earliest recognizable dorsal ectodermal primordium of the central nervous system present near the end of gastrulation before infolding to form the neural keel; consists of a thickened pseudostratified epithelium. Kimmel et al, 1995.[TAO] (...) at some stage of its development, every chordate exhibits five uniquely derived characters or synapomorphies of the group: (...) (4) a single, tubular nerve cord that is located dorsal to the notochord (...).[well established][VHOG] @@ -36484,34 +36707,34 @@ MH: sexual subtypes should probably be logically defined based on sexual process neural plate https://upload.wikimedia.org/wikipedia/commons/8/8f/Neural_Crest.png - + - + - + - + GOTAX:0000352 - + Wikipedia - + Bgee:AN @@ -36576,7 +36799,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + The paraxial mesoderm is the mesoderm located bilaterally adjacent to the notochord and neural tube[GO]. Mesoderm lateral to the neural tube and notochord that is divided into cranial and post-cranial portions. The trunk portions further segment into somites.[AAO] Presently, Cephalochordata, Urochordata, and Vertebrata are placed as subphyla of the phylum Chordata, in which the overall organization of embryonic tissues (dorsal hollow nerve cord, ventral digestive tract, axial notochord, and bilateral paraxial mesoderm) is largely conserved. In contrast, the echinoderms and hemichordates are sister groups of the chordates and they lack the notochord and paraxial mesoderm. Thus, the basic mesodermal organization of vertebrates must have appeared first in the common ancestor of the chordates.[well established][VHOG] @@ -36605,7 +36828,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process paraxial mesoderm http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png - + @@ -36618,7 +36841,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + Bgee:AN @@ -36690,7 +36913,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + @@ -36734,7 +36957,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process lateral plate mesoderm http://upload.wikimedia.org/wikipedia/commons/6/64/Gray19_with_color.png - + @@ -36747,7 +36970,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + EHDAA2 VHOG @@ -36831,7 +37054,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + @@ -36874,7 +37097,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process myotome http://upload.wikimedia.org/wikipedia/commons/9/96/Gray65.png - + @@ -36887,7 +37110,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + EHDAA2-abduced @@ -36943,8 +37166,8 @@ MH: sexual subtypes should probably be logically defined based on sexual process - - + + Ventral somitic compartment that is a precursor of the axial skeleton[XAO]. Sclerotomes eventually differentiate into the vertebrae and most of the skull. The caudal (posterior) half of one sclerotome fuses with the rostral (anterior) half of the adjacent one to form each vertebra. From their initial location within the somite, the sclerotome cells migrate medially towards the notochord. These cells meet the sclerotome cells from the other side to form the vertebral body. From this vertebral body, sclerotome cells move dorsally and surround the developing spinal cord, forming the vertebral arch[WP]. Skeletogenic portion of somites.[AAO] The vertebrate sclerotome has no equivalent in amphioxus and is a novelty linked with the evolution of the axial skeleton.[well established][VHOG] @@ -36971,11 +37194,11 @@ MH: sexual subtypes should probably be logically defined based on sexual process sclerotome http://upload.wikimedia.org/wikipedia/commons/9/96/Gray65.png - + - + @@ -36994,13 +37217,13 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + VHOG:0000680 - + ZFA @@ -37209,7 +37432,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + The part of the coelom in the embryo between the somatopleuric and splanchnopleuric mesoderm; the principal body cavities of the trunk (thoracic, abdominal, and pelvic) arise from this embryonic part of the coelom. consider merging with coelom. TODO - add spatial relationships to halves of LPM. Note the OG places XAO and ZFA coelem terms here. editor note: TODO check ZFA, which appears to be a structure present in adults (...) I regard it unlikely that coeloms of all bilaterian animals are comparable and evolved very early. Considering all these questions, few convincing characters concerning the evolution of body cavities remain to be named. (...) A segmental coelom appears to have evolved at least two times, in Annelida and in Myomerata (Acrania and Craniota).[well established][VHOG] @@ -37225,14 +37448,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process intraembryonic coelom - + - + Wikipedia @@ -37560,7 +37783,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + The bilaminar epithelium formed from the myotome and dermatome. Epithelial sheet on the external surface of the somite that gives rise to trunk, muscle and dermis. Within the dermomyotome there is also a medio-lateral difference. The central region makes dermis, the mesenchymal connective tissue of the back skin. The medial region (closest to neural tube) makes epaxial muscle, and the lateral region (furthest from neural tube) makes hypaxial muscle[http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=eurekah&part=A66768]. Epithelial sheet on the external surface of the somite that gives rise to trunk, muscle and dermis.[TAO] @@ -37583,7 +37806,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process UBERON:0004290 dermomyotome - + @@ -37602,7 +37825,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + EHDAA2 ZFA @@ -37928,7 +38151,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + A specialized form of connective tissue in which the extracellular matrix is firm, providing the tissue with resilience, and/or mineralized and that functions in mechanical and structural support.[VSAO]. A specialized form of connective tissue in which the extracellular matrix is firm, providing the tissue with resilience, and/or mineralized and that functions in mechanical and structural support.[VSAO] EMAPA:37744 @@ -37942,7 +38165,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process Four classes of mineralized tissues are found in vertebrates: bone, cartilage, dentine, and enamel. We think of cartilage and bone as skeletal tissues and of enamel and dentine as dental tissues, but enamel and dentine arose evolutionarily together with bone as skeletal tissues in the dermal skeleton (exoskeleton) of early vertebrates. Scales and teeth of sharks are examples of dermal skeletal elements that are still composed of the three ancient components-enamel, dentine, and bone. Cartilage, on the other hand, provided the basis for the second vertebrate skeletal system, the endoskeleton (Smith and Hall, 1990; Hall, 1998a,b). some invertebrate skeletal tissues have surprisingly bone-like features. Examples include chondrocytes interconnected by cell processes in cephalopod cartilages (Cole and Hall, 2004a,b), and the calcium phosphate layer in the shells of brachiopods (Rodland et al., 2003). However, neither bone nor mineralized cartilage have been found in invertebrates. Editors notes: TODO - develops_from skeletal tissue - + @@ -37955,7 +38178,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + 2012-08-14 VSAO:0000015 VSAO @@ -37994,7 +38217,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + Organ consisting of skeletal tissue. Encompasses whole bones, fused bones, cartilaginious elements, teeth, dermal denticles. Organ entity that is typically involved in mechanical support and may have different skeletal tissue compositions at different stages.[VSAO] Organ entity that may have different tissue compositions at different stages and is typically involved in mechanical support.[TAO] @@ -38010,14 +38233,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process skeletal element - + - + VSAO @@ -38062,7 +38285,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + @@ -38101,14 +38324,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process UBERON:0004770 articular system - + - + FMA @@ -38575,7 +38798,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + Mesenchyme that is part of a developing trunk. EFO:0003485 EHDAA2:0002092 @@ -38591,14 +38814,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process trunk mesenchyme - + - + EHDAA2 @@ -38895,7 +39118,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + A delimited region of dense mesenchyme within looser mesenchyme. AEO:0000148 EHDAA2_RETIRED:0003148 @@ -38905,7 +39128,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process UBERON:0005856 developing mesenchymal condensation - + @@ -38924,7 +39147,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + AEO-modified-relation @@ -39029,7 +39252,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + The notochordal plate is the dorsal part of the notochordal process when the ventral portion breaks down. It is continuous laterally with the endoderm that composes the roof of the primitive foregut and is in contact dorsally with the neural tube. The folding off of the notochordal plate gives rise to the notochord. TODO - check ordering; awaiting confirmation from JB The notochordal plate is the dorsal part of the notochordal process when the ventral portion breaks down. It is continuous laterally with the endoderm that composes the roof of the primitive foregut and is in contact dorsally with the neural tube. The folding off of the notochordal plate gives rise to the notochord. [Carson_JL, Dehart_DB, Developmental_Dynamics_(1994)_201:_260-278, Gesteland_K_and_Schoenwolf_GC, Inagaki_T, Morphogenesis_of_the_murine_node_and_notochordal_plate, The_prechordal_plate, Vrablic_T, see_Mueller_F_and_O'Rahilly_R, the_rostral_end_of_the_notochord_and_nearby_median_features_in_staged_human_embryos._Cells_Tissues_Organs_(2003)_173:_1-20_and_Sulik_K][VHOG] @@ -39044,7 +39267,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process notochordal plate - + @@ -39057,7 +39280,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + EHDAA2 @@ -39094,7 +39317,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + A midline cellular cord formed from the migration of mesenchymal cells from the primitive knot. EHDAA2:0001279 EHDAA:224 @@ -39111,14 +39334,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process The notochordal process grows cranially until it reaches the prechordal plate, the future site of the mouth. In this area the ectoderm is attached directly to the endoderm without intervening mesoderm. This area is known as the oropharyngeal membrane, and it will break down to become the mouth. At the other end of the primitive streak the ectoderm is also fused directly to the endoderm; this is known as the cloacal membrane (proctodeum), or primordial anus. notochordal process - + - + EHDAA2 @@ -39576,7 +39799,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + A hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood or analogs[GO,modified]. note we reserve the subclass 'heart' from the vertebrate multi-chambered heart. 'The first heart-like organ is believed to have appeared 500my ago in an ancestral bilaterian'. Amniotes: four-chambered heart. Amphibians: two atria, one ventricle, pulmonary; fish: single atrium and ventricle; amphioxus: tubular, non-striated, closed, unidirectional; ascidians: tubular, striated, open, bidirectional; arthropods: tubular, open; C elegans: contractile pharynx; Cnideria: striated muscle cells associated with gastrodermis SPD:0000130 @@ -39591,14 +39814,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process Gene notes: Bmp, Nkx, Gata primary circulatory organ - + - + GO uses blood circulation generically to include the haemolymphatic fluid of arthropods @@ -39688,7 +39911,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + @@ -39705,14 +39928,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process presumptive segmental plate - + - + https://github.com/obophenotype/uberon/wiki/The-neural-crest EDHAA2 @@ -39811,7 +40034,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + @@ -39837,7 +40060,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process presumptive paraxial mesoderm - + @@ -39853,7 +40076,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + https://github.com/obophenotype/uberon/issues/1277 @@ -39902,7 +40125,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + Mesenchyme with little extracellular matrix. AEO:0000146 EHDAA2:0003146 @@ -39910,7 +40133,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process UBERON:0007524 dense mesenchyme tissue - + @@ -39923,7 +40146,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + AEO @@ -40233,7 +40456,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + @@ -40250,14 +40473,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process UBERON:0009142 entire embryonic mesenchyme - + - + EHDAA2 @@ -40279,7 +40502,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + EHDAA2:0002094 trunk and cervical paraxial mesenchyme uberon @@ -40287,14 +40510,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process UBERON:0009618 trunk paraxial mesoderm - + - + EHDAA2 @@ -40454,8 +40677,8 @@ MH: sexual subtypes should probably be logically defined based on sexual process - - + + Anatomical cluster consisting of the skeletal elements (i.e. bone elements, cartilage elements, cartilage condensations) that are part of an individual subdivision of the organism. Excludes joints. Anatomical cluster consisting of the skeletal elements that are part of the skeleton.[VSAO] FMA:23879 @@ -40468,11 +40691,11 @@ MH: sexual subtypes should probably be logically defined based on sexual process subdivision of skeleton - + - + @@ -40485,13 +40708,13 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + UBERONREF:0000003 - + VSAO @@ -40862,7 +41085,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + @@ -40887,7 +41110,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process UBERON:0011899 epimysium - + @@ -40900,7 +41123,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + FMA @@ -41006,7 +41229,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + @@ -41028,7 +41251,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process UBERON:0012429 hematopoietic tissue - + @@ -41041,7 +41264,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + defitional @@ -41609,7 +41832,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + @@ -41632,7 +41855,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process UBERON:0016887 entire extraembryonic component - + @@ -41645,7 +41868,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + AEO @@ -41731,7 +41954,7 @@ MH: sexual subtypes should probably be logically defined based on sexual process - + @@ -41747,14 +41970,14 @@ MH: sexual subtypes should probably be logically defined based on sexual process skeletal musculature - + - + MA @@ -42042,196 +42265,6 @@ MH: sexual subtypes should probably be logically defined based on sexual process - - - - - - - - - example to be eventually removed - example to be eventually removed - - - - - - - - failed exploratory term - The term was used in an attempt to structure part of the ontology but in retrospect failed to do a good job - Person:Alan Ruttenberg - failed exploratory term - - - - - - - - metadata complete - Class has all its metadata, but is either not guaranteed to be in its final location in the asserted IS_A hierarchy or refers to another class that is not complete. - metadata complete - - - - - - - - organizational term - Term created to ease viewing/sort terms for development purpose, and will not be included in a release - organizational term - - - - - - - - ready for release - Class has undergone final review, is ready for use, and will be included in the next release. Any class lacking "ready_for_release" should be considered likely to change place in hierarchy, have its definition refined, or be obsoleted in the next release. Those classes deemed "ready_for_release" will also derived from a chain of ancestor classes that are also "ready_for_release." - ready for release - - - - - - - - metadata incomplete - Class is being worked on; however, the metadata (including definition) are not complete or sufficiently clear to the branch editors. - metadata incomplete - - - - - - - - uncurated - Nothing done yet beyond assigning a unique class ID and proposing a preferred term. - uncurated - - - - - - - - pending final vetting - All definitions, placement in the asserted IS_A hierarchy and required minimal metadata are complete. The class is awaiting a final review by someone other than the term editor. - pending final vetting - - - - - - - - placeholder removed - placeholder removed - - - - - - - - terms merged - An editor note should explain what were the merged terms and the reason for the merge. - terms merged - - - - - - - - term imported - This is to be used when the original term has been replaced by a term imported from an other ontology. An editor note should indicate what is the URI of the new term to use. - term imported - - - - - - - - term split - This is to be used when a term has been split in two or more new terms. An editor note should indicate the reason for the split and indicate the URIs of the new terms created. - term split - - - - - - - - universal - Hard to give a definition for. Intuitively a "natural kind" rather than a collection of any old things, which a class is able to be, formally. At the meta level, universals are defined as positives, are disjoint with their siblings, have single asserted parents. - Alan Ruttenberg - A Formal Theory of Substances, Qualities, and Universals, http://ontology.buffalo.edu/bfo/SQU.pdf - universal - - - - - - - - defined class - A defined class is a class that is defined by a set of logically necessary and sufficient conditions but is not a universal - "definitions", in some readings, always are given by necessary and sufficient conditions. So one must be careful (and this is difficult sometimes) to distinguish between defined classes and universal. - Alan Ruttenberg - defined class - - - - - - - - named class expression - A named class expression is a logical expression that is given a name. The name can be used in place of the expression. - named class expressions are used in order to have more concise logical definition but their extensions may not be interesting classes on their own. In languages such as OWL, with no provisions for macros, these show up as actuall classes. Tools may with to not show them as such, and to replace uses of the macros with their expansions - Alan Ruttenberg - named class expression - - - - - - - - to be replaced with external ontology term - Terms with this status should eventually replaced with a term from another ontology. - Alan Ruttenberg - group:OBI - to be replaced with external ontology term - - - - - - - - requires discussion - A term that is metadata complete, has been reviewed, and problems have been identified that require discussion before release. Such a term requires editor note(s) to identify the outstanding issues. - Alan Ruttenberg - group:OBI - requires discussion - - - -