diff --git a/panel/io/resources.py b/panel/io/resources.py
index 5a1d9f8100..ee87fa1690 100644
--- a/panel/io/resources.py
+++ b/panel/io/resources.py
@@ -183,7 +183,7 @@ def set_resource_mode(mode):
         _settings.resources.set_value(old_resources)
 
 def use_cdn() -> bool:
-    return _settings.resources(default="server") != 'server'
+    return _settings.resources(default="server") != 'server' or state._is_pyodide
 
 def get_dist_path(cdn: bool | Literal['auto'] = 'auto') -> str:
     cdn = use_cdn() if cdn == 'auto' else cdn