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GI-GIST.html
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<!DOCTYPE html PUBLIC "-//W3C//DTD XHTML 1.0 Transitional//EN" "http://www.w3.org/TR/xhtml1/DTD/xhtml1-transitional.dtd">
<html>
<html xmlns="http://www.w3.org/1999/xhtml">
<head>
<meta http-equiv="Content-Type" content="text/html; charset=UTF-8">
<title>GIST</title>
<link rel="stylesheet" type="text/css" href="view.css" media="all">
<script type="text/javascript" src="view.js"></script>
<script>
function updateDescription (frm)
{
var Template = "";
/*
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Template += "- Tumor site: " + "\n" + frm.A02.value + "\n";
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if (frm.A03.value !== ""){
Template += "- Tumor size: " + "\n" + frm.A03.value + "\n";
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if (frm.A04.value !== ""){
Template += "- Tumor focality: " + "\n" + frm.A04.value + "\n";
}
*/
if (frm.A05.value !== ""){
Template += "- Tumor histology and immunohistochemical studies: " + "\n" + " - " + frm.A05.value + "\n";
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if (frm.A06.value !== ""){
Template += "\n" + "- Histologic type: " + frm.A06.value + "\n";
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if (frm.A08.value !== ""){
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if (frm.A09.value !== ""){
Template += "- Necrosis: " + frm.A09.value + "\n";
}
if (frm.A10.value !== ""){
Template += "- KIT (CD117) IHC: " + frm.A10.value + "\n";
}
if (frm.A11.value !== ""){
Template += "- DOG1 IHC: " + frm.A11.value + "\n";
}
if (frm.A36.value !== ""){
Template += "- SDHB IHC: " + frm.A36.value + "\n";
}
if (frm.A11a.value !== ""){
Template += "- Lymphovascular invasion: " + frm.A11a.value + "\n";
}
if (frm.A12.value !== ""){
Template += "- Perineural invasion: " + frm.A12.value + "\n";
}
if (frm.A13.value !== ""){
Template += "- Risk assessment: " + frm.A13.value + "\n";
}
if (frm.A14.value !== ""){
Template += "- Presurgical treatment: " + frm.A14.value + "\n";
}
if (frm.A15.value !== ""){
Template += "- Treatment effect: " + frm.A15.value + "\n";
}
if (frm.A16.value !== ""){
Template += "\n" + "- Surgical margins: " + frm.A16.value + "\n" ;
}
if (frm.A17.value + frm.A18.value + frm.A19.value + frm.A20.value + frm.A21.value !== ""){
Template += "\n" + "- Lymph nodes examination: " + "\n";
}
if (frm.A17.value !== ""){
Template += " - Number of regional lymph nodes examined: " + frm.A17.value + "\n";
}
if (frm.A18.value !== ""){
Template += " - Number of lymph nodes involved: " + frm.A18.value + "\n";
}
if (frm.A19.value !== ""){
Template += " - Extranodal extension (ENE) : " + frm.A19.value + "\n";
}
if (frm.A20.value !== ""){
Template += " - Size of largest metastatic deposit (mm), specify site: " + frm.A20.value + "\n";
}
if (frm.A21.value !== ""){
Template += " - Size of largest lymph node involved (mm), specify site: " + frm.A21.value + "\n";
}
if (document.getElementById("A30").checked || document.getElementById("A31").checked ||
document.getElementById("A32").checked || document.getElementById("A33").checked ||
document.getElementById("A34").checked || document.getElementById("A35").checked ){
Template += "\n" + "- Distant metastasis:" + "\n";
}
if (document.getElementById("A30").checked){
Template += frm.A30.value + "\n";
}
if (document.getElementById("A31").checked){
Template += frm.A31.value + "\n";
}
if (document.getElementById("A32").checked){
Template += frm.A32.value + "\n";
}
if (document.getElementById("A33").checked){
Template += frm.A33.value + "\n";
}
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Template += frm.A34.value + "\n";
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Template += frm.A35.value + "\n";
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document.getElementById("A24").checked || frm.A25.value + frm.A26.value + frm.A27.value
!== ""){
Template += "\n" + "- Pathologic stage classification (pTNM, AJCC 8th edition):" + "\n";
}
if (document.getElementById("A22").checked || document.getElementById("A23").checked ||
document.getElementById("A24").checked){
Template += " - TNM Descriptors:" + "\n";
}
if (document.getElementById("A22").checked){
Template += " " + frm.A22.value + "\n";
}
if (document.getElementById("A23").checked){
Template += " " + frm.A23.value + "\n";
}
if (document.getElementById("A24").checked){
Template += " " +frm.A24.value + "\n";
}
if (frm.A25.value !== ""){
Template += " - Primary tumor (pT): " + "\n" + " " + frm.A25.value + "\n";
}
if (frm.A26.value !== ""){
Template += " - Regional lymph nodes (pN): " + "\n" + " " + frm.A26.value + "\n";
}
if (frm.A27.value !== ""){
Template += " - Distant metastasis: " + "\n" + " " + frm.A27.value + "\n";
}
/**
if (frm.A28.value !== ""){
Template += " - Specify site(s): " + frm.A28.value + "\n";
}
**/
if (frm.A29.value !== ""){
Template += "\n" + "- Additional notes: " + "\n" + " - " + frm.A29.value + "\n";
}
frm.holdtext.value = Template;
}
function CopyToClipboard() {
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var copyText = document.getElementById("holdtext");
/* Select the text field */
copyText.select();
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document.execCommand("copy");
/* Alert the copied text */
alert("Report copied to clipboard");
}
</script>
<style>
table, th, td {
border: 1px solid silver;
border-collapse: collapse;
padding: 4px;
}
</style>
</head>
<body>
<img id="top" src="top.png" alt="">
<div id="form_container">
<div class="form_description">
<h2>
<a href=".\cap\Cancer-Protocols-2022-12-Update\Gastrointestinal Protocol Folder\Stomach.GIST_4.3.0.0.REL_CAPCP.pdf" target="_blank">
<div class="tooltip">
Gastrointestinal stromal tumor
<span class="tooltiptext">click to access explanations in the original CAP template</span>
</div>
<a>
</h2>
</div>
<form>
<p> This is additional protocol for <a href=".\cap\Cancer-Protocols-2021-06-Update\Gastrointestinal-Protocol-Folder\Stomach.GIST.Bx_4.2.0.0.REL_CAPCP.pdf" target="_blank">biopsy specimen of GIST</a>.</p>
<p> This is additional protocol for <a href=".\cap\Cancer-Protocols-2022-12-Update\Gastrointestinal Protocol Folder\Stomach.GIST.Bmk_1.1.0.0.REL_CAPCP.pdf" target="_blank">biomarkers of GIST</a>.</p>
<!--
<p>
<fieldset style="border-color:#e6e6ff;">
<legend><label class="description">Gross descriptions:</label></legend>
<p>
<table border="1">
<col width="40%">
<tr>
<td>
<label class="description">- Procedure:</label>
</td>
<td>
<select class="element select large" ID="A01">
<option value=""></option>
<option value=" - Local excision">Local excision</option>
<option value=" - Resection, specify type:">Resection, specify type:</option>
<option value=" - Metastasectomy">Metastasectomy</option>
<option value=" - Other (specify):">Other (specify):</option>
<option value=" - Not specified">Not specified</option>
</select>
</td>
</tr>
<tr>
<td>
<label class="description">- Tumor site:</label>
</td>
<td>
<select class="element select large" ID="A02">
<option value=""></option>
<option value=" - Specify:">Specify:</option>
<option value=" - Not specified">Not specified</option>
</select>
</td>
</tr>
<tr>
<td>
<label class="description">- Tumor size:</label>
</td>
<td>
<select class="element select large" ID="A03">
<option value=""></option>
<option value=" - Greatest dimension (mm): ">Greatest dimension (mm): </option>
<option value=" - All dimensions (mm x mm x mm): ">All dimensions (mm x mm x mm):</option>
<option value=" - Cannot be determined (explain):">Cannot be determined (explain):</option>
</select>
</td>
</tr>
<tr>
<td>
<label class="description">- Tumor focality:</label>
</td>
<td>
<select class="element select large" ID="A04">
<option value=""></option>
<option value=" - Unifocal">Unifocal</option>
<option value=" - Multifocal, specify size and number:">Multifocal, specify size and number:</option>
</select>
</td>
</tr>
</table>
</p>
</fieldset>
</p>
-->
<p> GIST might be associated with several syndrome: Carney triad, Carney-Strakatis syndrome, Neurofibromatosis type 1, Familial GIST syndrome, etc.
</p>
<p>
<fieldset style="border-color:#e6e6ff;">
<legend><label class="description">Microscopic descriptions:</label></legend>
<p><label class="description">- Tumor histology and immunohistochemical studies: </label>
<textarea ID="A05" class="element textarea medium"></textarea>
</p>
<p>
<table border="1">
<col width="60%">
<tr>
<td>
<label class="description">- Histologic type:</label>
</td>
<td>
<select class="element select large" ID="A06">
<option value=""></option>
<option value="Gastrointestinal stromal tumor, spindle cell type">Gastrointestinal stromal tumor, spindle cell type</option>
<option value="Gastrointestinal stromal tumor, epithelioid type">Gastrointestinal stromal tumor, epithelioid type</option>
<option value="Gastrointestinal stromal tumor, mixed">Gastrointestinal stromal tumor, mixed</option>
<option value="Gastrointestinal stromal tumor, other (specify):">Gastrointestinal stromal tumor, other (specify):</option>
</select>
</td>
</tr>
<tr>
<td rowspan="2" valign="top">
<label class="description">- <a href=".\cap\Cancer-Protocols-2021-06-Update\Gastrointestinal-Protocol-Folder\Stomach.GIST_4.2.0.0.REL_CAPCP.pdf#page=9" target="_blank">Histologic grade</a>:</label>
Using 22 mm eyepiece at 40x objective, count active proliferative areas for 42 fields (equals 10 mm<sup>2</sup>), divide by 2 to get mitotic count for 5 mm<sup>2</sup>
</td>
<td>
<select class="element select large" ID="A07">
<option value=""></option>
<option value="G1: Low grade; mitotic rate < or = 5/5 mm2">G1: Low grade; mitotic rate < or = 5/5 mm2</option>
<option value="G2: High grade; mitotic rate > 5/5 mm2">G2: High grade; mitotic rate > 5/5 mm2</option>
<option value="GX: Cannot be assessed">GX: Cannot be assessed</option>
</select>
</td>
</tr>
<tr>
<td>
<label>- Mitotic count:</label><br>
<select class="element select large" ID="A08">
<option value=""></option>
<option value="< or = 5 mitoses/5 mm2, specify:">< or = 5 mitoses/5 mm2, specify:</option>
<option value="> 5 mitoses/5 mm2, specify:"> > 5 mitoses/5 mm2, specify:</option>
<option value="Cannot be determined (explain):"> Cannot be determined (explain):</option>
<option value="Not applicable"> Not applicable</option>
</select>
</td>
</tr>
<tr>
<td>
<label class=""> + Necrosis:</label>
</td>
<td>
<select class="element select large" ID="A09">
<option value=""></option>
<option value="Not identified">Not identified</option>
<option value="Present, extent (%):">Present, extent (%):</option>
<option value="Cannot be assessed">Cannot be assessed</option>
</select>
</td>
</tr>
<tr>
<td>
<label class=""> + <a href=".\cap\Cancer-Protocols-2022-12-Update\Gastrointestinal Protocol Folder\Stomach.GIST_4.3.0.0.REL_CAPCP.pdf#page=15" target="_blank">KIT (CD117) IHC</a>: </label>
</td>
<td>
<select class="element select large" ID="A10">
<option value=""></option>
<option value="Negative">Negative</option>
<option value="Positive">Positive</option>
<option value="Cannot be determined">Cannot be determined</option>
</select>
</td>
</tr>
<tr>
<td>
<label class=""> + <a href=".\cap\Cancer-Protocols-2022-12-Update\Gastrointestinal Protocol Folder\Stomach.GIST_4.3.0.0.REL_CAPCP.pdf#page=15" target="_blank">DOG1 IHC</a>: </label>
</td>
<td>
<select class="element select large" ID="A11">
<option value=""></option>
<option value="Negative">Negative</option>
<option value="Positive">Positive</option>
<option value="Cannot be determined">Cannot be determined</option>
</select>
</td>
</tr>
<tr>
<td>
<label class=""> + <a href=".\cap\Cancer-Protocols-2022-12-Update\Gastrointestinal Protocol Folder\Stomach.GIST_4.3.0.0.REL_CAPCP.pdf#page=15" target="_blank">SDHB IHC</a>: </label>
</td>
<td>
<select class="element select large" ID="A36">
<option value=""></option>
<option value="Intact">Intact</option>
<option value="Deficient">Deficient</option>
<option value="Cannot be determined">Cannot be determined</option>
</select>
</td>
</tr>
<tr>
<td>
<label class=""> + Lymphovascular invasion: </label>
</td>
<td>
<select class="element select large" ID="A11a">
<option value=""></option>
<option value="Not identified">Not identified</option>
<option value="Present">Present</option>
<option value="Cannot be determined">Cannot be determined</option>
</select>
</td>
</tr>
<tr>
<td>
<label class=""> + Perineural invasion: </label>
</td>
<td>
<select class="element select large" ID="A12">
<option value=""></option>
<option value="Not identified">Not identified</option>
<option value="Present">Present</option>
<option value="Cannot be determined">Cannot be determined</option>
</select>
</td>
</tr>
<tr>
<td>
<label class="description">- <a href=".\cap\Cancer-Protocols-2021-06-Update\Gastrointestinal-Protocol-Folder\Stomach.GIST_4.2.0.0.REL_CAPCP.pdf#page=10" target="_blank">Risk assessment (Miettinen and Lasota 2006)</a>: </label>
</td>
<td>
<select class="element select large" ID="A13">
<option value=""></option>
<option value="None">None</option>
<option value="Not applicable">Not applicable</option>
<option value="Very low risk">Very low risk</option>
<option value="Low risk">Low risk</option>
<option value="Moderate risk">Moderate risk</option>
<option value="High risk">High risk</option>
<option value="Overtly malignant/metastatic">Overtly malignant/metastatic</option>
<option value="Cannot be determined">Cannot be determined</option>
</select>
</td>
</tr>
<tr>
<td>
<label class=""> + Presurgical treatment: </label>
</td>
<td>
<select class="element select large" ID="A14">
<option value=""></option>
<option value="No known presurgical therapy">No known presurgical therapy</option>
<option value="Previous biopsy or surgery (specify):">Previous biopsy or surgery (specify):</option>
<option value="Systemic therapy performed (specify type):">Systemic therapy performed (specify type):</option>
<option value="Therapy performed, type not specified">Therapy performed, type not specified</option>
<option value="Not specified">Not specified</option>
</select>
</td>
</tr>
<tr>
<td>
<label class="description">- Treatment effect: </label>
</td>
<td>
<select class="element select large" ID="A15">
<option value=""></option>
<option value="No known presurgical therapy">No known presurgical therapy</option>
<option value="Not identified">Not identified</option>
<option value="Present, percentage of viable tumor:">Present, percentage of viable tumor:</option>
<option value="Cannot be determined">Cannot be determined</option>
</select>
</td>
</tr>
</table>
</p>
<p>
+ <a href=".\cap\Cancer-Protocols-2022-12-Update\Gastrointestinal Protocol Folder\Stomach.GIST_4.3.0.0.REL_CAPCP.pdf#page=16" target="_blank">Molecular studies</a> for hot spot mutations of KIT, PDGFRA, RAS or BRAF genes</a> are available in our AP molecular pathology lab. Other possible molecular analysis includes SDHA/B/C/D, NF1 and FGFR1 fusion (not available).</p>
<p>
<a href=".\cap\Cancer-Protocols-2021-06-Update\Gastrointestinal-Protocol-Folder\Stomach.GIST_4.2.0.0.REL_CAPCP.pdf#page=10" target="_blank"><img src=".\cap\GI-gist-risk-assessment.jpg" alt="Risk assessment" width="600"></a>
</p>
</fieldset>
</p>
<p>
<fieldset style="border-color:#e6e6ff;">
<legend><label class="description">Surgical margins:</label></legend>
<p>
<select class="element select medium" ID="A16">
<option value=""></option>
<option value="Cannot be assessed">Cannot be assessed</option>
<option value="Involved by GIST, specify:">Involved by GIST, specify:</option>
<option value="Uninvolved by GIST, specify location and distance (mm):">Uninvolved by GIST, specify location and distance (mm):</option>
</select>
</p>
</fieldset>
</p>
<p>
<fieldset style="border-color:#e6e6ff;">
<legend> <label class="description"> <a href=".\cap\Cancer-Protocols-2021-06-Update\Gastrointestinal-Protocol-Folder\Stomach.GIST_4.2.0.0.REL_CAPCP.pdf#page=11" target="_blank">Regional lymph nodes</a>: </label></legend>
<p>
<table border="1">
<col width="75%">
<tr>
<td>
<label class="description">- Number of regional lymph nodes examined:</label>
</td>
<td>
<input type="text" class="element text large" ID="A17" size="5">
</td>
</tr>
<tr>
<td>
<label class="description">- Number of lymph nodes involved:</label>
</td>
<td>
<input type="text" class="element text large" ID="A18" size="5">
</td>
</tr>
<tr>
<td>
<label class="description">- Extracapsular spread:</label>
</td>
<td>
<select class="element select large" ID="A19">
<option value=""></option>
<option value="Not identified">Not identified</option>
<option value="Present">Present</option>
<option value="Cannot be determined">Cannot be determined</option>
</select>
</td>
</tr>
<tr>
<td>
<label class="description">- Size of largest metastatic deposit (mm), specify site:</label>
</td>
<td>
<input type="text" class="element text large" ID="A20" size="5">
</td>
</tr>
<tr>
<td>
<label class="description">- Size of largest lymph node involved (mm), specify site:</label>
</td>
<td>
<input type="text" class="element text large" ID="A21" size="5">
</td>
</tr>
</table>
</p>
</fieldset>
</p>
<p>
<fieldset style="border-color:#e6e6ff;">
<legend> <label class="description"> Distant Metastasis: </label></legend>
<input class="element checkbox" type="checkbox" id="A30" value=" - Not applicable"><label class="choice" >Not applicable</label>
<input class="element checkbox" type="checkbox" id="A31" value=" - Not identified"><label class="choice" >Not identified</label>
<input class="element checkbox" type="checkbox" id="A32" value=" - Non-regional lymph node(s) (specify):"><label class="choice" >Non-regional lymph node(s) (specify):</label>
<input class="element checkbox" type="checkbox" id="A33" value=" - Liver (specify):"><label class="choice" >Liver (specify):</label>
<input class="element checkbox" type="checkbox" id="A34" value=" - Other (specify):"><label class="choice" >Other (specify):</label>
<input class="element checkbox" type="checkbox" id="A35" value=" - Cannot be determined: "><label class="choice" >Cannot be determined: </label>
</fieldset>
</p>
<p>
<fieldset style="border-color:#e6e6ff;">
<legend> <label class="description"> <a href=".\cap\Cancer-Protocols-2021-06-Update\Gastrointestinal-Protocol-Folder\Stomach.GIST_4.2.0.0.REL_CAPCP.pdf#page=12" target="_blank">Pathologic Stage Classification (AJCC 8e)</a>:</label></legend>
<p>
<table border="1">
<col width="40%">
<tr>
<td valign="top">
<label class="description">- TNM Descriptors:</label>
</td>
<td>
<input class="element checkbox" type="checkbox" id="A22" value=" m (multiple primary tumors) "><label class="choice">m (multiple primary tumors)</label>
<input class="element checkbox" type="checkbox" id="A23" value=" r (recurrent) "><label class="choice">r (recurrent)</label>
<input class="element checkbox" type="checkbox" id="A24" value=" y (post treatment) "><label class="choice">y (post treatment)</label>
</td>
</tr>
<tr>
<td>
<label class="description">- Primary tumor (pT):</label>
</td>
<td>
<select class="element select large" ID="A25">
<option value=""></option>
<option value=" - pT not assigned (cannot be determined based on available pathological information)">pT not assigned (cannot be determined based on available pathological information)</option>
<option value=" - pT0: No evidence of primary tumor">pT0: No evidence of primary tumor</option>
<option value=" - pT1: Tumor 2 cm or less">pT1: Tumor 2 cm or less</option>
<option value=" - pT2: Tumor more than 2 cm but not more than 5 cm">pT2: Tumor more than 2 cm but not more than 5 cm</option>
<option value=" - pT3: Tumor more than 5 cm but not more than 10 cm">pT3: Tumor more than 5 cm but not more than 10 cm</option>
<option value=" - pT4: Tumor more than 10 cm in greatest dimension">pT4: Tumor more than 10 cm in greatest dimension</option>
</select>
</td>
</tr>
<tr>
<td>
<label class="description">- Regional lymph nodes (pN):</label>
</td>
<td>
<select class="element select large" ID="A26">
<option value=""></option>
<option value=" - pN not assigned (no nodes submitted or found)">pN not assigned (no nodes submitted or found)</option>
<option value=" - pN not assigned (cannot be determined based on available pathological information)"> pN not assigned (cannot be determined based on available pathological information)</option>
<option value=" - pN0: No regional lymph node metastasis">pN0: No regional lymph node metastasis</option>
<option value=" - pN1: Regional lymph node metastasis">pN1: Regional lymph node metastasis</option>
</select>
</td>
</tr>
<tr>
<td rowspan="2" valign="top">
<label class="description">- Distant metastasis (pM):</label>
</td>
<td>
<select class="element select large" ID="A27">
<option value=""></option>
<option value=" - Not applicable - pM cannot be determined from the submitted specimen(s)">Not applicable - pM cannot be determined from the submitted specimen(s)</option>
<option value=" - pM1: Distant metastasis">pM1: Distant metastasis</option>
</select>
</td>
</tr>
<!--
<tr>
<td>
<label>- Specify site(s), if known:</label>
<input type="text" class="element text medium" ID="A28" size="35">
</td>
-->
</table>
</p>
</fieldset>
</p>
<p>
<label class="description">- Additional notes:</label>
<textarea ID="A29" class = "element textarea medium" style="border-color:Grey;"></textarea>
</p>
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Last upated on 14-Jan-2023,<br>
based on <a href="https://www.cap.org/protocols-and-guidelines/cancer-reporting-tools/cancer-protocol-templates" target="_blank">US CAP cancer protocol templates</a>.<br>
GIST Resection 4.3.0.0 (Dec 2022),<br>
html form was created on <a href="https://www.phpform.org">pForm</a>, <a href="https://www.w3schools.com/">W3 School</a>, <a href="https://stackoverflow.com/">StackOverflow</a>, and <a href="https://icons8.com">Icons8</a>.<br><br>
Anatomical Pathology Division, Queen Mary Hospital, Hong Kong.
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