diff --git a/monai/engines/trainer.py b/monai/engines/trainer.py
index a0be86bae5..64fca6bcc7 100644
--- a/monai/engines/trainer.py
+++ b/monai/engines/trainer.py
@@ -46,7 +46,7 @@ class Trainer(Workflow):
 
     """
 
-    def run(self) -> None:  # type: ignore[override]
+    def run(self, *args) -> None:  # type: ignore[override]
         """
         Execute training based on Ignite Engine.
         If call this function multiple times, it will continuously run from the previous state.
diff --git a/monai/handlers/__init__.py b/monai/handlers/__init__.py
index c1fa448f25..f25ef680cc 100644
--- a/monai/handlers/__init__.py
+++ b/monai/handlers/__init__.py
@@ -29,6 +29,8 @@
 from .metrics_reloaded_handler import MetricsReloadedBinaryHandler, MetricsReloadedCategoricalHandler
 from .metrics_saver import MetricsSaver
 from .mlflow_handler import MLFlowHandler
+from .model_calibrator import ModelCalibrater
+from .model_quantizer import ModelQuantizer
 from .nvtx_handlers import MarkHandler, RangeHandler, RangePopHandler, RangePushHandler
 from .panoptic_quality import PanopticQuality
 from .parameter_scheduler import ParamSchedulerHandler
diff --git a/monai/handlers/model_calibrator.py b/monai/handlers/model_calibrator.py
new file mode 100644
index 0000000000..76a3681b89
--- /dev/null
+++ b/monai/handlers/model_calibrator.py
@@ -0,0 +1,62 @@
+# Copyright (c) MONAI Consortium
+# Licensed under the Apache License, Version 2.0 (the "License");
+# you may not use this file except in compliance with the License.
+# You may obtain a copy of the License at
+#     http://www.apache.org/licenses/LICENSE-2.0
+# Unless required by applicable law or agreed to in writing, software
+# distributed under the License is distributed on an "AS IS" BASIS,
+# WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+# See the License for the specific language governing permissions and
+# limitations under the License.
+
+from __future__ import annotations
+
+from functools import partial
+from typing import TYPE_CHECKING
+
+import modelopt.torch.quantization as mtq
+import torch
+
+from monai.utils import IgniteInfo, min_version, optional_import
+
+Events, _ = optional_import("ignite.engine", IgniteInfo.OPT_IMPORT_VERSION, min_version, "Events")
+Checkpoint, _ = optional_import("ignite.handlers", IgniteInfo.OPT_IMPORT_VERSION, min_version, "Checkpoint")
+if TYPE_CHECKING:
+    from ignite.engine import Engine
+else:
+    Engine, _ = optional_import("ignite.engine", IgniteInfo.OPT_IMPORT_VERSION, min_version, "Engine")
+
+
+class ModelCalibrater:
+    """
+    Model quantizer is for model quantization. It takes a model as input and convert it to a quantized
+    model.
+
+    Args:
+        model: the model to be quantized.
+        example_inputs: the example inputs for the model quantization. examples::
+            (torch.randn(256,256,256),)
+        config: the calibration config.
+
+    """
+
+    def __init__(self, model: torch.nn.Module, export_path: str, config: dict = mtq.INT8_SMOOTHQUANT_CFG) -> None:
+        self.model = model
+        self.export_path = export_path
+        self.config = config
+
+    def attach(self, engine: Engine) -> None:
+        """
+        Args:
+            engine: Ignite Engine, it can be a trainer, validator or evaluator.
+        """
+        engine.add_event_handler(Events.STARTED, self)
+
+    @staticmethod
+    def _model_wrapper(engine, model):
+        engine.run()
+
+    def __call__(self, engine) -> None:
+        quant_fun = partial(self._model_wrapper, engine)
+        model = mtq.quantize(self.model, self.config, quant_fun)
+        torch.save(model.state_dict(), self.export_path)
diff --git a/monai/handlers/model_quantizer.py b/monai/handlers/model_quantizer.py
new file mode 100644
index 0000000000..4a6c69ad34
--- /dev/null
+++ b/monai/handlers/model_quantizer.py
@@ -0,0 +1,71 @@
+# Copyright (c) MONAI Consortium
+# Licensed under the Apache License, Version 2.0 (the "License");
+# you may not use this file except in compliance with the License.
+# You may obtain a copy of the License at
+#     http://www.apache.org/licenses/LICENSE-2.0
+# Unless required by applicable law or agreed to in writing, software
+# distributed under the License is distributed on an "AS IS" BASIS,
+# WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+# See the License for the specific language governing permissions and
+# limitations under the License.
+
+from __future__ import annotations
+
+from collections.abc import Sequence
+from types import MethodType
+from typing import TYPE_CHECKING
+
+import torch
+from torch.ao.quantization.quantize_pt2e import prepare_qat_pt2e
+from torch.ao.quantization.quantizer import Quantizer
+from torch.ao.quantization.quantizer.xnnpack_quantizer import XNNPACKQuantizer, get_symmetric_quantization_config
+
+from monai.utils import IgniteInfo, min_version, optional_import
+
+Events, _ = optional_import("ignite.engine", IgniteInfo.OPT_IMPORT_VERSION, min_version, "Events")
+Checkpoint, _ = optional_import("ignite.handlers", IgniteInfo.OPT_IMPORT_VERSION, min_version, "Checkpoint")
+if TYPE_CHECKING:
+    from ignite.engine import Engine
+else:
+    Engine, _ = optional_import("ignite.engine", IgniteInfo.OPT_IMPORT_VERSION, min_version, "Engine")
+
+
+class ModelQuantizer:
+    """
+    Model quantizer is for model quantization. It takes a model as input and convert it to a quantized
+    model.
+
+    Args:
+        model: the model to be quantized.
+        example_inputs: the example inputs for the model quantization. examples::
+            (torch.randn(256,256,256),)
+        quantizer: quantizer for the quantization job.
+
+    """
+
+    def __init__(
+        self, model: torch.nn.Module, example_inputs: Sequence, export_path: str, quantizer: Quantizer | None = None
+    ) -> None:
+        self.model = model
+        self.example_inputs = example_inputs
+        self.export_path = export_path
+        self.quantizer = (
+            XNNPACKQuantizer().set_global(get_symmetric_quantization_config()) if quantizer is None else quantizer
+        )
+
+    def attach(self, engine: Engine) -> None:
+        """
+        Args:
+            engine: Ignite Engine, it can be a trainer, validator or evaluator.
+        """
+        engine.add_event_handler(Events.STARTED, self.start)
+        engine.add_event_handler(Events.ITERATION_COMPLETED, self.epoch)
+
+    def start(self) -> None:
+        self.model = torch.export.export_for_training(self.model, self.example_inputs).module()
+        self.model = prepare_qat_pt2e(self.model, self.quantizer)
+        self.model.train = MethodType(torch.ao.quantization.move_exported_model_to_train, self.model)
+        self.model.eval = MethodType(torch.ao.quantization.move_exported_model_to_eval, self.model)
+
+    def epoch(self) -> None:
+        torch.save(self.model.state_dict(), self.export_path)
diff --git a/requirements-dev.txt b/requirements-dev.txt
index 72654d3534..bf25c9f535 100644
--- a/requirements-dev.txt
+++ b/requirements-dev.txt
@@ -61,3 +61,4 @@ pyamg>=5.0.0
 git+https://github.com/facebookresearch/segment-anything.git@6fdee8f2727f4506cfbbe553e23b895e27956588
 onnx_graphsurgeon
 polygraphy
+nvidia-modelopt>=0.19.0