diff --git a/Modules/ThirdParty/TIFF/CMakeLists.txt b/Modules/ThirdParty/TIFF/CMakeLists.txt
index c95b6d100f2..c59acfc01b0 100644
--- a/Modules/ThirdParty/TIFF/CMakeLists.txt
+++ b/Modules/ThirdParty/TIFF/CMakeLists.txt
@@ -8,17 +8,16 @@ if(ITK_USE_SYSTEM_TIFF)
   find_package(TIFF REQUIRED)
   set(ITKTIFF_INCLUDE_DIRS
     ${ITKTIFF_BINARY_DIR}/src
+    ${TIFF_INCLUDE_DIRS}
     )
-  set(ITKTIFF_SYSTEM_INCLUDE_DIRS
-    ${TIFF_INCLUDE_DIR}
-    )
+
   set(ITKTIFF_LIBRARIES "${TIFF_LIBRARIES}")
   set(ITKTIFF_NO_SRC 1)
 
   # Check availability of different methods to access TIFF's field
   # data structure.
   include(CheckTypeSize)
-  set(CMAKE_REQUIRED_INCLUDES ${ITKTIFF_SYSTEM_INCLUDE_DIRS})
+  set(CMAKE_REQUIRED_LIBRARIES TIFF::TIFF)
   set(CMAKE_EXTRA_INCLUDE_FILES "tiffio.h")
   check_type_size(TIFFFieldReadCount ITK_TIFF_HAS_TIFFFieldReadCount)
   check_type_size(TIFFField*  ITK_TIFF_HAS_TIFFField)